HOXD9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The exact role of this gene has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1gonadal mesoderm development (GO:0007506)8.76196188
2* peripheral nervous system neuron development (GO:0048935)6.73776064
3mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)6.12058291
4metanephric mesenchyme development (GO:0072075)5.62092849
5regulation of cardioblast proliferation (GO:0003264)5.61277965
6regulation of secondary heart field cardioblast proliferation (GO:0003266)5.61277965
7* proximal/distal pattern formation (GO:0009954)5.48145730
8enteric nervous system development (GO:0048484)5.43290159
9regulation of heart morphogenesis (GO:2000826)5.39574671
10cranial nerve morphogenesis (GO:0021602)5.36199538
11mesenchymal cell differentiation involved in renal system development (GO:2001012)5.34562614
12mesenchymal cell differentiation involved in kidney development (GO:0072161)5.34562614
13metanephric tubule development (GO:0072170)5.31388381
14metanephric nephron tubule development (GO:0072234)5.31388381
15lymph vessel development (GO:0001945)5.30598578
16metanephric epithelium development (GO:0072207)5.29730151
17cell migration involved in heart development (GO:0060973)5.24923482
18kidney mesenchyme development (GO:0072074)5.24653114
19embryonic skeletal joint morphogenesis (GO:0060272)5.02282068
20aminoglycoside antibiotic metabolic process (GO:0030647)4.97445615
21endocardial cushion morphogenesis (GO:0003203)4.92682145
22metanephric nephron epithelium development (GO:0072243)4.87332746
23negative regulation of catenin import into nucleus (GO:0035414)4.83615047
24renal absorption (GO:0070293)4.79365763
25mesonephros development (GO:0001823)4.78654903
26glomerular basement membrane development (GO:0032836)4.64675173
27excretion (GO:0007588)4.58972452
28urogenital system development (GO:0001655)4.45423123
29organ induction (GO:0001759)4.42642463
30paraxial mesoderm development (GO:0048339)4.40471043
31cell differentiation involved in metanephros development (GO:0072202)4.29465291
32mesenchymal to epithelial transition (GO:0060231)4.28122731
33nephron tubule development (GO:0072080)4.26565040
34negative regulation of metanephros development (GO:0072217)4.21235333
35regulation of cardioblast differentiation (GO:0051890)4.15097784
36outflow tract septum morphogenesis (GO:0003148)4.12964494
37neuron fate specification (GO:0048665)4.10242969
38drug transmembrane transport (GO:0006855)4.06969908
39nephron tubule formation (GO:0072079)4.04044626
40thyroid gland development (GO:0030878)4.01813983
41nephron tubule morphogenesis (GO:0072078)3.95285247
42nephron epithelium morphogenesis (GO:0072088)3.95285247
43regulation of apoptotic process involved in morphogenesis (GO:1902337)3.94857764
44cochlea morphogenesis (GO:0090103)3.92928303
45urate metabolic process (GO:0046415)3.88632060
46middle ear morphogenesis (GO:0042474)3.88456519
47* forelimb morphogenesis (GO:0035136)3.85302273
48coronary vasculature morphogenesis (GO:0060977)3.84771786
49negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.80023512
50regulation of mesenchymal cell apoptotic process (GO:2001053)3.78139763
51generation of neurons (GO:0048699)3.77454301
52metanephros development (GO:0001656)3.77197792
53myoblast migration (GO:0051451)3.75949561
54renal tubule morphogenesis (GO:0061333)3.75710159
55renal tubule development (GO:0061326)3.73631203
56nephron epithelium development (GO:0072009)3.72146387
57polarized epithelial cell differentiation (GO:0030859)3.64843983
58pattern specification involved in kidney development (GO:0061004)3.63893234
59chondrocyte proliferation (GO:0035988)3.62378818
60positive regulation of male gonad development (GO:2000020)3.61533281
61aorta morphogenesis (GO:0035909)3.60736741
62organic cation transport (GO:0015695)3.56986778
63outer ear morphogenesis (GO:0042473)3.55841608
64response to mercury ion (GO:0046689)3.55439805
65* embryonic organ morphogenesis (GO:0048562)3.54093426
66anterior/posterior axis specification, embryo (GO:0008595)3.50911783
67* embryonic forelimb morphogenesis (GO:0035115)3.50710277
68collecting duct development (GO:0072044)3.47318952
69glomerulus development (GO:0032835)3.46860212
70positive regulation of chondrocyte differentiation (GO:0032332)3.45233677
71glucocorticoid biosynthetic process (GO:0006704)3.44726775
72eyelid development in camera-type eye (GO:0061029)3.44566022
73regulation of organ formation (GO:0003156)3.43019400
74Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.42419767
75response to parathyroid hormone (GO:0071107)3.40082100
76neural crest cell development (GO:0014032)3.38855552
77regulation of male gonad development (GO:2000018)3.37586662
78regulation of mammary gland epithelial cell proliferation (GO:0033599)3.35537311
79embryonic digit morphogenesis (GO:0042733)3.34965896
80positive regulation of odontogenesis (GO:0042482)3.33273370
81cardiac muscle cell proliferation (GO:0060038)3.28933642
82uterus development (GO:0060065)3.27318816
83drug transport (GO:0015893)3.26431682
84anatomical structure regression (GO:0060033)3.24880963
85embryonic cranial skeleton morphogenesis (GO:0048701)3.23787174
86regulation of establishment of planar polarity (GO:0090175)3.23627492
87* embryonic skeletal system morphogenesis (GO:0048704)3.23524003
88regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.20938136
89positive regulation of transcription regulatory region DNA binding (GO:2000679)3.19154292
90phosphate ion transport (GO:0006817)3.18034171
91G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.17050051
92regulation of branching involved in ureteric bud morphogenesis (GO:0090189)3.16894752
93mesenchyme development (GO:0060485)3.15208170
94segment specification (GO:0007379)3.15053092
95planar cell polarity pathway involved in neural tube closure (GO:0090179)3.14975857
96mesenchymal cell development (GO:0014031)3.14782860
97mesenchymal cell differentiation (GO:0048762)3.14042847
98regulation of cell proliferation involved in heart morphogenesis (GO:2000136)3.12981167
99neuron projection extension involved in neuron projection guidance (GO:1902284)3.12689414
100axon extension involved in axon guidance (GO:0048846)3.12689414
101cell differentiation involved in kidney development (GO:0061005)3.11969418
102positive regulation of cartilage development (GO:0061036)3.11186032
103branching involved in ureteric bud morphogenesis (GO:0001658)3.10341289
104regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.09360448
105polyol transport (GO:0015791)3.07936883
106regulation of mesonephros development (GO:0061217)3.06461126
107regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.05528827
108sex determination (GO:0007530)3.05346187
109regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.03363566
110morphogenesis of an epithelial fold (GO:0060571)3.03305624
111notochord development (GO:0030903)3.02847620
112collagen fibril organization (GO:0030199)3.02689681
113basement membrane organization (GO:0071711)3.02653598
114regulation of metanephros development (GO:0072215)3.01588766
115diaphragm development (GO:0060539)3.01428784
116muscle cell proliferation (GO:0033002)3.00448645
117protein heterotrimerization (GO:0070208)2.99820419
118lysine catabolic process (GO:0006554)2.99761231
119lysine metabolic process (GO:0006553)2.99761231
120vascular endothelial growth factor signaling pathway (GO:0038084)2.98941011
121cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.98550929
122regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.98521436
123cranial nerve structural organization (GO:0021604)2.97232543
124endothelial cell morphogenesis (GO:0001886)2.94780161
125mesenchyme morphogenesis (GO:0072132)2.94447896
126glomerular visceral epithelial cell development (GO:0072015)2.90743003
127* embryonic limb morphogenesis (GO:0030326)2.90558796
128* embryonic appendage morphogenesis (GO:0035113)2.90558796
129hippo signaling (GO:0035329)2.90452362
130androgen biosynthetic process (GO:0006702)2.90381146
131striated muscle cell proliferation (GO:0014855)2.89612548
132skeletal muscle organ development (GO:0060538)2.88937548
133lung vasculature development (GO:0060426)2.88842591
134diterpenoid biosynthetic process (GO:0016102)2.87700991
135embryonic eye morphogenesis (GO:0048048)2.86811312
136artery morphogenesis (GO:0048844)2.85776552
137head development (GO:0060322)2.85729124
138developmental induction (GO:0031128)2.84077833
139renal filtration (GO:0097205)2.83694844
140midgut development (GO:0007494)2.83460370
141outflow tract morphogenesis (GO:0003151)2.83400576
142glomerular filtration (GO:0003094)2.83115070
143vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.81253645
144regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.80698932
145muscle cell migration (GO:0014812)2.80378872
146regulation of stem cell maintenance (GO:2000036)2.79522766
147non-canonical Wnt signaling pathway (GO:0035567)2.78771557
148negative regulation of embryonic development (GO:0045992)2.78245558
149negative regulation of kidney development (GO:0090185)2.77863407
150* skeletal system morphogenesis (GO:0048705)2.76729607
151* hindlimb morphogenesis (GO:0035137)2.73789115
152muscle cell fate commitment (GO:0042693)2.73040821
153regulation of chromatin binding (GO:0035561)2.72840105
154trophoblast giant cell differentiation (GO:0060707)2.71198312
155axis elongation (GO:0003401)2.69548333
156* anterior/posterior pattern specification (GO:0009952)2.68679217
157protein retention in ER lumen (GO:0006621)2.68370871
158* limb morphogenesis (GO:0035108)2.68207422
159* appendage morphogenesis (GO:0035107)2.68207422
160pharyngeal system development (GO:0060037)2.67935843
161cell-cell signaling involved in cell fate commitment (GO:0045168)2.67924702
162cell migration in hindbrain (GO:0021535)2.67473755
163eye morphogenesis (GO:0048592)2.67431387
164maternal placenta development (GO:0001893)2.65799910
165positive regulation of fatty acid beta-oxidation (GO:0032000)2.65768428
166negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.62362611
167bone trabecula formation (GO:0060346)2.61660173
168mesonephric tubule development (GO:0072164)2.60525673

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RARG_19884340_ChIP-ChIP_MEFs_Mouse3.31338499
2* EED_16625203_ChIP-ChIP_MESCs_Mouse3.10129256
3* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.99280127
4ESR1_21235772_ChIP-Seq_MCF-7_Human2.95492741
5CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.66410768
6* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.62447545
7* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.62447545
8* EZH2_27304074_Chip-Seq_ESCs_Mouse2.62091522
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.57130019
10* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.52402689
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.48875305
12E2F7_22180533_ChIP-Seq_HELA_Human2.46107857
13* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.36962126
14* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.34083615
15ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.32945466
16TP63_17297297_ChIP-ChIP_HaCaT_Human2.30651939
17ELK3_25401928_ChIP-Seq_HUVEC_Human2.29689652
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.29162860
19CDX2_19796622_ChIP-Seq_MESCs_Mouse2.28981696
20* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.28320237
21* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.24648825
22* TP53_20018659_ChIP-ChIP_R1E_Mouse2.20177652
23* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.17841412
24NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.17455886
25* CBX2_27304074_Chip-Seq_ESCs_Mouse2.13350817
26* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.11999208
27* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.09436766
28FOXM1_23109430_ChIP-Seq_U2OS_Human2.08881092
29SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.08436614
30* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.01914385
31WT1_19549856_ChIP-ChIP_CCG9911_Human1.98843788
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.95395392
33TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92961814
34CLOCK_20551151_ChIP-Seq_293T_Human1.90712808
35* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.89443126
36HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.87393499
37LXR_22292898_ChIP-Seq_THP-1_Human1.82991901
38GBX2_23144817_ChIP-Seq_PC3_Human1.79228448
39TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.78240997
40* EZH2_27294783_Chip-Seq_ESCs_Mouse1.67723357
41ESR1_15608294_ChIP-ChIP_MCF-7_Human1.67674519
42PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.67472802
43ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.64363825
44KDM2B_26808549_Chip-Seq_SUP-B15_Human1.62609012
45* RNF2_27304074_Chip-Seq_NSC_Mouse1.62277936
46* RING1B_27294783_Chip-Seq_NPCs_Mouse1.61698644
47P300_27058665_Chip-Seq_ZR-75-30cells_Human1.59011551
48RNF2_27304074_Chip-Seq_ESCs_Mouse1.58345167
49PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.58152213
50* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.57926385
51KDM2B_26808549_Chip-Seq_K562_Human1.56662241
52KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.55049100
53* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.53699489
54UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.53630805
55MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.52252660
56TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.52215314
57VDR_22108803_ChIP-Seq_LS180_Human1.51921207
58NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.51665134
59SMAD_19615063_ChIP-ChIP_OVARY_Human1.50681292
60HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.50071424
61XRN2_22483619_ChIP-Seq_HELA_Human1.48395466
62POU5F1_16153702_ChIP-ChIP_HESCs_Human1.47225923
63ESR1_20079471_ChIP-ChIP_T-47D_Human1.44206493
64* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.39580171
65UBF1/2_26484160_Chip-Seq_HMECs_Human1.38551086
66* TET1_21451524_ChIP-Seq_MESCs_Mouse1.37631604
67CJUN_26792858_Chip-Seq_BT549_Human1.36113794
68TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.35083357
69CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.34304791
70EP300_21415370_ChIP-Seq_HL-1_Mouse1.33523194
71CDX2_20551321_ChIP-Seq_CACO-2_Human1.32254068
72MYC_18555785_ChIP-Seq_MESCs_Mouse1.31460326
73EGR1_19374776_ChIP-ChIP_THP-1_Human1.31302837
74SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.28661354
75KDM2B_26808549_Chip-Seq_DND41_Human1.28354398
76ISL1_27105846_Chip-Seq_CPCs_Mouse1.27631767
77ZNF217_24962896_ChIP-Seq_MCF-7_Human1.24501232
78KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.24392620
79KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.23443388
80KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.23443388
81KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.23443388
82* SA1_27219007_Chip-Seq_ERYTHROID_Human1.23106936
83VDR_21846776_ChIP-Seq_THP-1_Human1.20987677
84MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.20910341
85* RING1B_27294783_Chip-Seq_ESCs_Mouse1.20471724
86* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.19622617
87WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19574100
88CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.17537716
89AR_21909140_ChIP-Seq_LNCAP_Human1.16505711
90DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15978563
91CTCF_27219007_Chip-Seq_ERYTHROID_Human1.15351729
92RBPJ_22232070_ChIP-Seq_NCS_Mouse1.14650605
93MYC_22102868_ChIP-Seq_BL_Human1.14421507
94KDM2B_26808549_Chip-Seq_JURKAT_Human1.13820843
95* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.13467633
96PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.13362836
97KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13266440
98CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.11603046
99PIAS1_25552417_ChIP-Seq_VCAP_Human1.11448524
100POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.10884430
101ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.08839707
102RACK7_27058665_Chip-Seq_MCF-7_Human1.08716766
103ZFP281_18757296_ChIP-ChIP_E14_Mouse1.08198114
104TP53_18474530_ChIP-ChIP_U2OS_Human1.07910893
105RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.07316744
106SMAD3_21741376_ChIP-Seq_HESCs_Human1.06796912
107FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.06741810
108* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.06728256
109SMC1_22415368_ChIP-Seq_MEFs_Mouse1.06369847
110CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.06178731
111SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.06161851
112HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.05876378
113ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.05846783
114* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.05036355
115* STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.04877276
116CREB1_26743006_Chip-Seq_LNCaP_Human1.04731070
117TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.04589323
118CTCF_27219007_Chip-Seq_Bcells_Human1.03776869
119CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03501891
120AHR_22903824_ChIP-Seq_MCF-7_Human1.03366245
121* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03204740
122NANOG_16153702_ChIP-ChIP_HESCs_Human1.03120033
123CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01533840
124EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.00440895
125ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00321908
126ZNF263_19887448_ChIP-Seq_K562_Human1.00272200
127ZFX_18555785_ChIP-Seq_MESCs_Mouse0.99979035
128ERG_21242973_ChIP-ChIP_JURKAT_Human0.97400120
129SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96401935
130SMAD4_21741376_ChIP-Seq_HESCs_Human0.95549150
131CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95406974
132* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.95337240
133SOX2_20726797_ChIP-Seq_SW620_Human0.94724697
134ARNT_22903824_ChIP-Seq_MCF-7_Human0.94544133
135RXR_22108803_ChIP-Seq_LS180_Human0.93583004
136TP53_22127205_ChIP-Seq_IMR90_Human0.91279335
137TBX3_20139965_ChIP-Seq_ESCs_Mouse0.90230673
138* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.88956907
139TBX3_20139965_ChIP-Seq_MESCs_Mouse0.88187704
140* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.88162644
141TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88007179
142DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.87866048
143KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.87324192
144SALL4_18804426_ChIP-ChIP_XEN_Mouse0.86146996
145SOX2_16153702_ChIP-ChIP_HESCs_Human0.84722002
146SALL1_21062744_ChIP-ChIP_HESCs_Human0.83935884
147P53_22127205_ChIP-Seq_FIBROBLAST_Human0.83656912
148TP63_19390658_ChIP-ChIP_HaCaT_Human0.83340190
149TCF4_18268006_ChIP-ChIP_LS174T_Human0.83337133
150SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.82453079

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004043_abnormal_pH_regulation3.56496433
2MP0005503_abnormal_tendon_morphology3.43730794
3MP0003942_abnormal_urinary_system3.07259282
4MP0000534_abnormal_ureter_morphology3.04123587
5MP0005623_abnormal_meninges_morphology2.85778617
6MP0004272_abnormal_basement_membrane2.84564472
7MP0003385_abnormal_body_wall2.70511719
8MP0004019_abnormal_vitamin_homeostasis2.63079402
9MP0001346_abnormal_lacrimal_gland2.59145914
10MP0001756_abnormal_urination2.54312902
11MP0008438_abnormal_cutaneous_collagen2.49946545
12MP0001958_emphysema2.48997573
13MP0003315_abnormal_perineum_morphology2.44059597
14MP0009053_abnormal_anal_canal2.43476027
15MP0009250_abnormal_appendicular_skeleto2.28279206
16MP0000537_abnormal_urethra_morphology2.22624653
17MP0010030_abnormal_orbit_morphology2.11751417
18MP0003195_calcinosis2.09021135
19MP0002877_abnormal_melanocyte_morpholog2.07578460
20MP0000538_abnormal_urinary_bladder2.07236404
21MP0001765_abnormal_ion_homeostasis2.02932029
22MP0006054_spinal_hemorrhage1.98908827
23MP0003941_abnormal_skin_development1.97628754
24MP0002009_preneoplasia1.89644851
25MP0003878_abnormal_ear_physiology1.87724942
26MP0005377_hearing/vestibular/ear_phenot1.87724942
27MP0003122_maternal_imprinting1.87148689
28MP0009643_abnormal_urine_homeostasis1.82731834
29MP0003123_paternal_imprinting1.79299056
30MP0003283_abnormal_digestive_organ1.74149287
31MP0002160_abnormal_reproductive_system1.72617360
32MP0002136_abnormal_kidney_physiology1.69975194
33MP0000049_abnormal_middle_ear1.69362994
34MP0005409_darkened_coat_color1.65872830
35MP0005332_abnormal_amino_acid1.65245692
36MP0002108_abnormal_muscle_morphology1.63552121
37MP0004233_abnormal_muscle_weight1.59705572
38MP0002138_abnormal_hepatobiliary_system1.58270035
39* MP0002932_abnormal_joint_morphology1.57561718
40MP0009780_abnormal_chondrocyte_physiolo1.57017446
41MP0000678_abnormal_parathyroid_gland1.56295977
42MP0005367_renal/urinary_system_phenotyp1.56197326
43MP0000516_abnormal_urinary_system1.56197326
44MP0001879_abnormal_lymphatic_vessel1.53622337
45MP0002896_abnormal_bone_mineralization1.53527399
46* MP0002115_abnormal_skeleton_extremities1.51698149
47MP0003705_abnormal_hypodermis_morpholog1.49758613
48MP0010368_abnormal_lymphatic_system1.43591564
49MP0000003_abnormal_adipose_tissue1.40644365
50MP0002249_abnormal_larynx_morphology1.38519454
51MP0004145_abnormal_muscle_electrophysio1.37247203
52MP0005670_abnormal_white_adipose1.35648044
53MP0000733_abnormal_muscle_development1.31322450
54* MP0002109_abnormal_limb_morphology1.30673518
55MP0002876_abnormal_thyroid_physiology1.26086248
56MP0000762_abnormal_tongue_morphology1.25722906
57MP0003937_abnormal_limbs/digits/tail_de1.24953059
58MP0005508_abnormal_skeleton_morphology1.24411381
59MP0003115_abnormal_respiratory_system1.22870374
60* MP0002114_abnormal_axial_skeleton1.21846938
61MP0005257_abnormal_intraocular_pressure1.20733769
62MP0002135_abnormal_kidney_morphology1.18796646
63MP0001270_distended_abdomen1.18297982
64MP0000163_abnormal_cartilage_morphology1.18242497
65MP0004134_abnormal_chest_morphology1.17384851
66MP0002116_abnormal_craniofacial_bone1.17346373
67MP0005636_abnormal_mineral_homeostasis1.16560854
68MP0002282_abnormal_trachea_morphology1.15837385
69MP0005389_reproductive_system_phenotype1.15134752
70MP0002751_abnormal_autonomic_nervous1.14357356
71MP0003755_abnormal_palate_morphology1.13599755
72MP0003938_abnormal_ear_development1.11442611
73MP0002060_abnormal_skin_morphology1.11001249
74MP0002396_abnormal_hematopoietic_system1.10446706
75MP0005187_abnormal_penis_morphology1.09981381
76MP0002168_other_aberrant_phenotype1.08715049
77MP0000613_abnormal_salivary_gland1.08688456
78MP0001299_abnormal_eye_distance/1.07431807
79MP0002089_abnormal_postnatal_growth/wei1.07255627
80MP0000467_abnormal_esophagus_morphology1.07115958
81MP0003091_abnormal_cell_migration1.05180013
82MP0005197_abnormal_uvea_morphology1.04825572
83MP0000767_abnormal_smooth_muscle1.04423114
84MP0001661_extended_life_span1.02180463
85MP0002113_abnormal_skeleton_development1.01519362
86MP0003936_abnormal_reproductive_system1.00182292
87MP0001286_abnormal_eye_development0.99980706
88MP0004858_abnormal_nervous_system0.99490872
89MP0002697_abnormal_eye_size0.99241868
90MP0000751_myopathy0.98520315
91MP0005076_abnormal_cell_differentiation0.97577014
92MP0006138_congestive_heart_failure0.96514840
93MP0003935_abnormal_craniofacial_develop0.95622522
94MP0000428_abnormal_craniofacial_morphol0.95327591
95MP0000681_abnormal_thyroid_gland0.95157581
96MP0005084_abnormal_gallbladder_morpholo0.92679133
97MP0005375_adipose_tissue_phenotype0.88594148
98MP0003111_abnormal_nucleus_morphology0.86002028
99MP0004147_increased_porphyrin_level0.84799100
100MP0005275_abnormal_skin_tensile0.84723664
101MP0010386_abnormal_urinary_bladder0.83081311
102MP0003567_abnormal_fetal_cardiomyocyte0.82932562
103MP0002735_abnormal_chemical_nociception0.82898552
104MP0000432_abnormal_head_morphology0.82804020
105MP0001849_ear_inflammation0.82382986
106MP0004185_abnormal_adipocyte_glucose0.81909199
107MP0000230_abnormal_systemic_arterial0.80447503
108MP0005360_urolithiasis0.78075232
109MP0009379_abnormal_foot_pigmentation0.77640084
110MP0002233_abnormal_nose_morphology0.76258155
111MP0001919_abnormal_reproductive_system0.75964668
112MP0003121_genomic_imprinting0.75903065
113MP0005666_abnormal_adipose_tissue0.75538256
114MP0005023_abnormal_wound_healing0.75279457
115MP0003279_aneurysm0.75207915
116MP0002925_abnormal_cardiovascular_devel0.75184599
117MP0009278_abnormal_bone_marrow0.75092149
118MP0002928_abnormal_bile_duct0.75073987
119MP0000759_abnormal_skeletal_muscle0.74839305
120MP0008932_abnormal_embryonic_tissue0.74522118
121MP0000750_abnormal_muscle_regeneration0.73867621
122MP0005390_skeleton_phenotype0.73800140
123MP0003077_abnormal_cell_cycle0.73687850
124MP0002127_abnormal_cardiovascular_syste0.73322896
125MP0000350_abnormal_cell_proliferation0.73077298
126MP0009384_cardiac_valve_regurgitation0.72940878
127MP0001340_abnormal_eyelid_morphology0.72737970
128MP0002084_abnormal_developmental_patter0.72730973
129MP0004087_abnormal_muscle_fiber0.72299742
130MP0000579_abnormal_nail_morphology0.71952114
131MP0001614_abnormal_blood_vessel0.70054016
132MP0003566_abnormal_cell_adhesion0.69957754
133MP0008789_abnormal_olfactory_epithelium0.69884074
134MP0005171_absent_coat_pigmentation0.69169183
135MP0000013_abnormal_adipose_tissue0.68586697
136MP0005369_muscle_phenotype0.66996161
137MP0004484_altered_response_of0.66719073
138MP0005193_abnormal_anterior_eye0.66327095
139MP0001188_hyperpigmentation0.65556226
140MP0002085_abnormal_embryonic_tissue0.64175529
141* MP0002111_abnormal_tail_morphology0.62328577

Predicted human phenotypes

RankGene SetZ-score
1Metabolic alkalosis (HP:0200114)6.59710746
2Hypokalemic alkalosis (HP:0001949)6.14968123
3Hypomagnesemia (HP:0002917)5.60220207
4Increased circulating renin level (HP:0000848)5.58718857
5Hyperactive renin-angiotensin system (HP:0000841)5.34585593
6Abnormality of chloride homeostasis (HP:0011422)5.28949825
7Polyuria (HP:0000103)5.11072220
8Abnormality of magnesium homeostasis (HP:0004921)4.79271342
9Abnormal urine output (HP:0012590)4.68609496
10Abnormality of renal excretion (HP:0011036)4.41391148
11Abnormality of the phalanges of the hallux (HP:0010057)4.39187219
12Gout (HP:0001997)4.24387491
13Tetany (HP:0001281)4.20508718
14Renal salt wasting (HP:0000127)4.13601662
15Abnormal drinking behavior (HP:0030082)4.02954216
16Polydipsia (HP:0001959)4.02954216
17Hyperaldosteronism (HP:0000859)3.99251454
18Hypokalemia (HP:0002900)3.70341421
19Alkalosis (HP:0001948)3.70057296
20Abnormality of renin-angiotensin system (HP:0000847)3.64926691
21Shawl scrotum (HP:0000049)3.56080003
22Calcaneovalgus deformity (HP:0001848)3.53329470
23Deformed tarsal bones (HP:0008119)3.33371582
24Increased purine levels (HP:0004368)3.22548832
25Hyperuricemia (HP:0002149)3.22548832
26Bladder diverticulum (HP:0000015)3.19292335
27Lip pit (HP:0100267)3.10048311
28Premature rupture of membranes (HP:0001788)3.05772385
29Coronal craniosynostosis (HP:0004440)3.05298215
30Abnormality of potassium homeostasis (HP:0011042)2.97840130
31Turricephaly (HP:0000262)2.94737366
32Hypercalciuria (HP:0002150)2.93990727
33Genu recurvatum (HP:0002816)2.92143971
34Type 1 muscle fiber predominance (HP:0003803)2.88695770
35Protrusio acetabuli (HP:0003179)2.85174879
36Abnormality of the distal phalanges of the toes (HP:0010182)2.77971509
37Short middle phalanx of the 5th finger (HP:0004220)2.76354828
38Vertebral compression fractures (HP:0002953)2.74210586
39Abnormal umbilical cord blood vessels (HP:0011403)2.73361955
40Single umbilical artery (HP:0001195)2.73361955
41Abnormality of the fetal cardiovascular system (HP:0010948)2.73361955
42Mesomelia (HP:0003027)2.72588474
43Broad distal phalanx of finger (HP:0009836)2.70735975
44Proximal tubulopathy (HP:0000114)2.69958167
45Bicornuate uterus (HP:0000813)2.69919552
46Fragile skin (HP:0001030)2.66556116
47Abnormality of the distal phalanx of the thumb (HP:0009617)2.64557988
48Shallow orbits (HP:0000586)2.61749889
49Mitral valve prolapse (HP:0001634)2.59159850
50Bowel diverticulosis (HP:0005222)2.56417999
51Periauricular skin pits (HP:0100277)2.54689622
52Preauricular pit (HP:0004467)2.54689622
53Abnormality of the calcaneus (HP:0008364)2.48665500
54Focal segmental glomerulosclerosis (HP:0000097)2.48586335
55Abnormal ventriculo-arterial connection (HP:0011563)2.46621323
56Transposition of the great arteries (HP:0001669)2.46621323
57Abnormal connection of the cardiac segments (HP:0011545)2.46621323
58Aortic aneurysm (HP:0004942)2.44671508
59Aortic dissection (HP:0002647)2.44422458
60Deviation of the hallux (HP:0010051)2.44176384
61Hallux valgus (HP:0001822)2.37389052
62Glomerulosclerosis (HP:0000096)2.35893931
63Renal dysplasia (HP:0000110)2.32908043
64Cerebral aneurysm (HP:0004944)2.31228962
65Facial shape deformation (HP:0011334)2.29158397
66Potter facies (HP:0002009)2.29158397
67Abnormality of purine metabolism (HP:0004352)2.26175913
68Distal lower limb muscle weakness (HP:0009053)2.25842806
69Hyperacusis (HP:0010780)2.25545027
70Ankle contracture (HP:0006466)2.23757100
71Biconcave vertebral bodies (HP:0004586)2.23733363
72Spinal cord lesions (HP:0100561)2.21964272
73Syringomyelia (HP:0003396)2.21964272
74Vascular tortuosity (HP:0004948)2.20294122
75Cervical subluxation (HP:0003308)2.19779367
76Abnormality of dentin (HP:0010299)2.18489261
77Abnormality of sodium homeostasis (HP:0010931)2.17916076
78Abnormality of the parietal bone (HP:0002696)2.17790526
79Abnormality of the umbilical cord (HP:0010881)2.16815180
80Elbow flexion contracture (HP:0002987)2.16705632
81Short clavicles (HP:0000894)2.15497126
82Partial duplication of the phalanx of hand (HP:0009999)2.15328502
83Hypoventilation (HP:0002791)2.14125389
84Neonatal short-limb short stature (HP:0008921)2.14024957
85Hyperglycinuria (HP:0003108)2.13041866
86Renal duplication (HP:0000075)2.11044902
87Adrenal overactivity (HP:0002717)2.10027001
88Wrist flexion contracture (HP:0001239)2.09490957
89Male infertility (HP:0003251)2.08972837
90Rectal prolapse (HP:0002035)2.08028977
91Tubular atrophy (HP:0000092)2.06559624
92Arterial tortuosity (HP:0005116)2.06168294
93Atresia of the external auditory canal (HP:0000413)2.05862111
94Aplasia/Hypoplasia of the clavicles (HP:0006710)2.05725569
95Stridor (HP:0010307)2.05710876
96Dislocated radial head (HP:0003083)2.05473490
97Asymmetry of the thorax (HP:0001555)2.04763728
98Short 5th finger (HP:0009237)2.03354678
99Delayed cranial suture closure (HP:0000270)2.02018876
100Hyperextensible skin (HP:0000974)2.01682838
101Hypoplastic left heart (HP:0004383)2.01096719
102Lymphangioma (HP:0100764)1.98982060
103Midline defect of the nose (HP:0004122)1.98558664
104Abnormality of the radial head (HP:0003995)1.98244711
105Nephrocalcinosis (HP:0000121)1.96949449
106Wormian bones (HP:0002645)1.96840952
107Hip contracture (HP:0003273)1.95641653
108Advanced eruption of teeth (HP:0006288)1.95453721
109Long toe (HP:0010511)1.95327799
110Increased connective tissue (HP:0009025)1.93539412
111Follicular hyperkeratosis (HP:0007502)1.92741302
112Spinal rigidity (HP:0003306)1.92367357
113Unilateral renal agenesis (HP:0000122)1.91736691
114Blue sclerae (HP:0000592)1.91599822
115Broad face (HP:0000283)1.91297687
116Wide anterior fontanel (HP:0000260)1.90966373
117Mesangial abnormality (HP:0001966)1.90386333
118Hypoplasia of the iris (HP:0007676)1.89849386
119Short 4th metacarpal (HP:0010044)1.88660658
120Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.88660658
121Skin pits (HP:0100276)1.88298518
122Joint laxity (HP:0001388)1.87262525
123Natal tooth (HP:0000695)1.84954872
124Stage 5 chronic kidney disease (HP:0003774)1.82660931
125Breast hypoplasia (HP:0003187)1.82458317
126Camptodactyly of toe (HP:0001836)1.82209953
127Ulnar bowing (HP:0003031)1.82092949
128Abnormality of glutamine family amino acid metabolism (HP:0010902)1.82038326
129Selective tooth agenesis (HP:0001592)1.79496979
130Sprengel anomaly (HP:0000912)1.78604982
131Cardiovascular calcification (HP:0011915)1.76849304
132Overgrowth (HP:0001548)1.76489024
133Abnormality of proline metabolism (HP:0010907)1.76450510
134Hydroxyprolinuria (HP:0003080)1.76450510
135Septate vagina (HP:0001153)1.75338317
136Osteopenia (HP:0000938)1.75071155
137Renal tubular acidosis (HP:0001947)1.75034198
138Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.74898537
139Disproportionate tall stature (HP:0001519)1.74169776
140Thin bony cortex (HP:0002753)1.73517664
141Hyponatremia (HP:0002902)1.73366647
142Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.73276381
143Nemaline bodies (HP:0003798)1.72823157
144Aplasia of the musculature (HP:0100854)1.72574671
145Soft skin (HP:0000977)1.72475400
146Muscle fiber inclusion bodies (HP:0100299)1.72470496
147Abnormality of the anterior chamber (HP:0000593)1.72229310
148Flexion contracture of toe (HP:0005830)1.71670693
149Joint contractures involving the joints of the feet (HP:0100492)1.71670693
150Vascular calcification (HP:0004934)1.71501164
151Male pseudohermaphroditism (HP:0000037)1.71220450
152Abnormality of the aortic arch (HP:0012303)1.70991637
153Atrioventricular block (HP:0001678)1.70726950
154Abnormality of Sharpey fibers (HP:0100685)1.70525820
155Gonadotropin excess (HP:0000837)1.69904077
156Hypoplastic heart (HP:0001961)1.69108115
157Metaphyseal cupping (HP:0003021)1.68972386
158Generalized muscle weakness (HP:0003324)1.68437747
159Knee flexion contracture (HP:0006380)1.68007052
160Chondrocalcinosis (HP:0000934)1.67710486
161Hepatoblastoma (HP:0002884)1.67709674
162Infantile muscular hypotonia (HP:0008947)1.67086657
163Muscle fiber splitting (HP:0003555)1.66619608
164Hypercortisolism (HP:0001578)1.64712319
165Bowed forearm bones (HP:0003956)1.63244750
166Bowing of the arm (HP:0006488)1.63244750
167Fibular aplasia (HP:0002990)1.63175943
168Ectopia lentis (HP:0001083)1.63087958
169Persistence of primary teeth (HP:0006335)1.62928955
170Abnormality of the 4th metacarpal (HP:0010012)1.62201871
171Enlarged kidneys (HP:0000105)1.60934820
172Occipital encephalocele (HP:0002085)1.60490851
173Obstructive sleep apnea (HP:0002870)1.60448906
174Atrophic scars (HP:0001075)1.59590862
175Abnormal pancreas size (HP:0012094)1.56423263

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK45.72983124
2WNK35.63029803
3OXSR14.28033939
4AKT33.92020332
5CDK123.64041655
6LATS13.43499297
7STK38L3.25377339
8LATS23.02178219
9MYLK2.35053767
10STK392.34011578
11EPHB22.18158295
12ICK2.17753579
13NTRK12.15854082
14SMG12.14025622
15PDK22.12263643
16PDGFRA2.11857098
17TSSK62.07415672
18TIE11.85763021
19CASK1.83526981
20SGK2231.82979598
21SGK4941.82979598
22WNK11.79517401
23SGK21.72356879
24TRIB31.69938895
25MAP3K101.69916346
26KDR1.61858142
27NME21.58642899
28TTN1.57041481
29PRKD31.45075431
30PRPF4B1.44859651
31TGFBR21.44098102
32EPHA31.40693196
33SIK11.34514468
34FER1.32960256
35SGK31.29709855
36TAOK21.28378191
37PTK61.23345437
38NEK11.16782399
39PDK41.13897391
40PDK31.13897391
41RPS6KC11.13318879
42RPS6KL11.13318879
43CAMK1G1.10583697
44MAP3K31.09621348
45PIK3CG1.05500281
46PAK41.05453980
47STK31.01991579
48MAP3K60.96486853
49CDK40.96466280
50DDR20.96144841
51MKNK20.93808607
52PTK20.93004407
53RPS6KA60.92954294
54RET0.92230829
55MOS0.92008864
56RPS6KA20.91332803
57PAK20.91184066
58MKNK10.88257565
59RPS6KB20.87354227
60ERN10.83700476
61IRAK30.81149749
62CHEK20.79206175
63STK380.79011375
64PRKD20.78857637
65PINK10.77669001
66MET0.75974053
67FGFR10.73767729
68TRPM70.72335328
69MAPK150.70768735
70CAMK1D0.69912742
71BMX0.69760568
72FRK0.69487610
73MAP3K140.69319602
74PTK2B0.68485842
75PRKCI0.67589518
76NEK90.66188367
77MST1R0.65880124
78FLT30.65745172
79TGFBR10.65385631
80BCKDK0.64159817
81EEF2K0.62634866
82ERBB30.62237481
83CHEK10.61285621
84MAP2K30.58385780
85ATR0.57991709
86MAPK110.56158897
87GSK3A0.55055880
88CLK10.54741221
89CDK70.52063168
90TESK10.51652604
91NEK20.49384077
92TTK0.49116351
93CDK20.48034972
94RIPK10.47507096
95BRSK10.47018430
96INSRR0.45803323
97DMPK0.45720491
98FGFR40.45274029
99CDK60.44823954
100ILK0.44580034
101MAPK120.43053396
102CDK90.42309614
103MAP2K20.41960685
104SGK10.39888427
105PAK10.39394785
106CDK11A0.39108466
107MAPK10.37918312
108MAPKAPK50.37801924
109TYRO30.37758162
110PKN20.37326326
111DYRK1A0.37274786
112MAP3K70.37079653
113CDK150.36479048
114CSNK1G10.36084317
115PAK60.36005881
116CDK10.35329661
117MAPK140.34611321
118PNCK0.33613343
119EIF2AK20.33343090
120BRAF0.33007366
121CSNK1G30.32811829
122MTOR0.32028943
123EPHB10.31156806
124AKT20.30093025
125OBSCN0.29459317
126NUAK10.28822776
127CDK30.28695337
128MAPK70.27927565
129DYRK1B0.27284954
130MAP2K10.25846780
131LIMK10.25025168
132LRRK20.22854021
133CDK80.22564228
134MAPKAPK30.21880403
135MAPK130.21667984
136BRD40.21233300
137ROCK10.20808501
138PHKG20.20551097
139PHKG10.20551097
140PDGFRB0.20124593
141PAK30.19046371
142ERBB40.18231822
143PRKAA10.17876038
144CSNK1A1L0.16778879
145CDC42BPA0.15662750
146PRKCE0.15502657
147CCNB10.15466344
148AKT10.14975572
149PRKD10.14198458
150PRKAA20.14158561
151TNK20.13991459

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004603.75654297
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.32584266
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.79321789
4Hedgehog signaling pathway_Homo sapiens_hsa043402.64046461
5Propanoate metabolism_Homo sapiens_hsa006402.41119473
6Basal cell carcinoma_Homo sapiens_hsa052172.35101824
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.32247001
8Protein digestion and absorption_Homo sapiens_hsa049742.25433836
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.24289956
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.09654748
11Vitamin digestion and absorption_Homo sapiens_hsa049772.05751296
12Hippo signaling pathway_Homo sapiens_hsa043902.05257517
13Sulfur relay system_Homo sapiens_hsa041222.00639835
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.99336048
15Collecting duct acid secretion_Homo sapiens_hsa049661.98698285
16ECM-receptor interaction_Homo sapiens_hsa045121.98551505
17Pyruvate metabolism_Homo sapiens_hsa006201.93298152
18Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.83603195
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.81528131
20Butanoate metabolism_Homo sapiens_hsa006501.73617994
21TGF-beta signaling pathway_Homo sapiens_hsa043501.67453033
22Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.65894261
23Non-small cell lung cancer_Homo sapiens_hsa052231.63190948
24Focal adhesion_Homo sapiens_hsa045101.63086979
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.62338240
26Glioma_Homo sapiens_hsa052141.57704378
27Arginine and proline metabolism_Homo sapiens_hsa003301.53222782
28mTOR signaling pathway_Homo sapiens_hsa041501.50404843
29Melanoma_Homo sapiens_hsa052181.48634227
30Cell cycle_Homo sapiens_hsa041101.47388704
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.46572023
32Ovarian steroidogenesis_Homo sapiens_hsa049131.37560556
33Glycosaminoglycan degradation_Homo sapiens_hsa005311.37035356
34Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.35471486
35Central carbon metabolism in cancer_Homo sapiens_hsa052301.34927447
36Mineral absorption_Homo sapiens_hsa049781.34530283
37Sulfur metabolism_Homo sapiens_hsa009201.33998220
38Adherens junction_Homo sapiens_hsa045201.30017686
39Colorectal cancer_Homo sapiens_hsa052101.29020312
40Steroid hormone biosynthesis_Homo sapiens_hsa001401.26770251
41Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.24406417
42Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.19786527
43Tight junction_Homo sapiens_hsa045301.18955633
44Proteoglycans in cancer_Homo sapiens_hsa052051.17553063
45Thyroid hormone signaling pathway_Homo sapiens_hsa049191.14564363
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.13649638
47AMPK signaling pathway_Homo sapiens_hsa041521.13327203
48Glutathione metabolism_Homo sapiens_hsa004801.11873519
49VEGF signaling pathway_Homo sapiens_hsa043701.09612491
50Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.06219297
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.06026925
52DNA replication_Homo sapiens_hsa030301.05548902
53Wnt signaling pathway_Homo sapiens_hsa043101.05090946
54beta-Alanine metabolism_Homo sapiens_hsa004101.04988851
55Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.01549411
56Fatty acid metabolism_Homo sapiens_hsa012120.99614707
57Spliceosome_Homo sapiens_hsa030400.99320331
58Lysine degradation_Homo sapiens_hsa003100.99163582
59Small cell lung cancer_Homo sapiens_hsa052220.97336025
60One carbon pool by folate_Homo sapiens_hsa006700.96140890
61Bladder cancer_Homo sapiens_hsa052190.95627512
62Pentose and glucuronate interconversions_Homo sapiens_hsa000400.94980374
63Prostate cancer_Homo sapiens_hsa052150.94675818
64mRNA surveillance pathway_Homo sapiens_hsa030150.94460033
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.93810011
66PI3K-Akt signaling pathway_Homo sapiens_hsa041510.93121616
67Base excision repair_Homo sapiens_hsa034100.89350766
68Carbon metabolism_Homo sapiens_hsa012000.88526109
69Insulin signaling pathway_Homo sapiens_hsa049100.88449645
70Fatty acid degradation_Homo sapiens_hsa000710.88087857
71Renal cell carcinoma_Homo sapiens_hsa052110.87183626
72ErbB signaling pathway_Homo sapiens_hsa040120.87051034
73Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.86045040
74Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.85504007
75Endometrial cancer_Homo sapiens_hsa052130.83562910
76Aldosterone synthesis and secretion_Homo sapiens_hsa049250.83005895
77Arachidonic acid metabolism_Homo sapiens_hsa005900.82815053
78Axon guidance_Homo sapiens_hsa043600.82560741
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.82476549
80Peroxisome_Homo sapiens_hsa041460.82413224
81Rap1 signaling pathway_Homo sapiens_hsa040150.82163792
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.82126142
83Prion diseases_Homo sapiens_hsa050200.81235388
84p53 signaling pathway_Homo sapiens_hsa041150.80031993
85Pathways in cancer_Homo sapiens_hsa052000.78150376
86Other glycan degradation_Homo sapiens_hsa005110.77954582
87Amoebiasis_Homo sapiens_hsa051460.77700362
88Acute myeloid leukemia_Homo sapiens_hsa052210.76292680
89AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74791198
90Dilated cardiomyopathy_Homo sapiens_hsa054140.73471352
91Selenocompound metabolism_Homo sapiens_hsa004500.73158341
92Notch signaling pathway_Homo sapiens_hsa043300.73039725
93Tryptophan metabolism_Homo sapiens_hsa003800.70525518
94Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69316414
95Vitamin B6 metabolism_Homo sapiens_hsa007500.67130648
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66366759
97FoxO signaling pathway_Homo sapiens_hsa040680.64442239
98MicroRNAs in cancer_Homo sapiens_hsa052060.62738331
99Thyroid hormone synthesis_Homo sapiens_hsa049180.62548159
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61640673
101Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.61376415
102GnRH signaling pathway_Homo sapiens_hsa049120.60583107
103RNA transport_Homo sapiens_hsa030130.60479222
104Estrogen signaling pathway_Homo sapiens_hsa049150.60442966
105Bile secretion_Homo sapiens_hsa049760.60271311
106Gap junction_Homo sapiens_hsa045400.59305746
107Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.56501795
108Lysosome_Homo sapiens_hsa041420.56482111
109Vascular smooth muscle contraction_Homo sapiens_hsa042700.56306935
110Melanogenesis_Homo sapiens_hsa049160.56286732
111Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.54951076
112Vibrio cholerae infection_Homo sapiens_hsa051100.54806618
113Starch and sucrose metabolism_Homo sapiens_hsa005000.50084975
114Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49460103
115Renin-angiotensin system_Homo sapiens_hsa046140.48461049
116Dorso-ventral axis formation_Homo sapiens_hsa043200.48222915
117Pancreatic cancer_Homo sapiens_hsa052120.47266808
118Glucagon signaling pathway_Homo sapiens_hsa049220.47029407
119Leukocyte transendothelial migration_Homo sapiens_hsa046700.46912367
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.46444742
121Fructose and mannose metabolism_Homo sapiens_hsa000510.46433493
122Hepatitis B_Homo sapiens_hsa051610.46101160
123Pyrimidine metabolism_Homo sapiens_hsa002400.45553740
124Chronic myeloid leukemia_Homo sapiens_hsa052200.45249542
125Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45157522
126Inositol phosphate metabolism_Homo sapiens_hsa005620.45146527
127cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44455180
128Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44012605
129Circadian rhythm_Homo sapiens_hsa047100.43329871
130Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43056815
131Calcium signaling pathway_Homo sapiens_hsa040200.42872933
132Endocytosis_Homo sapiens_hsa041440.42701154
133Ribosome_Homo sapiens_hsa030100.42241051
134Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39754387
135Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35334242
136Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35060337
137Gastric acid secretion_Homo sapiens_hsa049710.34856809
138Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.34440736
139Thyroid cancer_Homo sapiens_hsa052160.34204449
140Rheumatoid arthritis_Homo sapiens_hsa053230.34082806
141PPAR signaling pathway_Homo sapiens_hsa033200.33947472
142Phagosome_Homo sapiens_hsa041450.32994267
143HTLV-I infection_Homo sapiens_hsa051660.31078218
144Ras signaling pathway_Homo sapiens_hsa040140.30574105
145MAPK signaling pathway_Homo sapiens_hsa040100.29770886
146Choline metabolism in cancer_Homo sapiens_hsa052310.29443955
147Biosynthesis of amino acids_Homo sapiens_hsa012300.29416713

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