HOXD4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in determining positional values in developing limb buds. Alternatively spliced variants have been described but their full length nature has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proximal/distal pattern formation (GO:0009954)6.36701409
2embryonic skeletal joint morphogenesis (GO:0060272)5.71630793
3glomerular basement membrane development (GO:0032836)5.28556433
4kidney mesenchyme development (GO:0072074)5.21185518
5metanephric mesenchyme development (GO:0072075)5.10587094
6outer ear morphogenesis (GO:0042473)5.05631031
7mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)5.00021499
8regulation of secondary heart field cardioblast proliferation (GO:0003266)4.92379814
9regulation of cardioblast proliferation (GO:0003264)4.92379814
10negative regulation of catenin import into nucleus (GO:0035414)4.91359371
11paraxial mesoderm development (GO:0048339)4.79680835
12thyroid gland development (GO:0030878)4.72912751
13planar cell polarity pathway involved in neural tube closure (GO:0090179)4.55278236
14mesonephros development (GO:0001823)4.44858740
15forelimb morphogenesis (GO:0035136)4.38234997
16cell migration involved in heart development (GO:0060973)4.29989925
17glomerular visceral epithelial cell development (GO:0072015)4.29317132
18embryonic forelimb morphogenesis (GO:0035115)4.25243107
19myoblast migration (GO:0051451)4.20131741
20regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.20065499
21pattern specification involved in kidney development (GO:0061004)4.08125218
22metanephric epithelium development (GO:0072207)4.06595713
23diaphragm development (GO:0060539)4.04627465
24organ induction (GO:0001759)4.01556464
25enteric nervous system development (GO:0048484)4.01370790
26embryonic skeletal system morphogenesis (GO:0048704)4.00432704
27polarized epithelial cell differentiation (GO:0030859)4.00314789
28anterior/posterior axis specification, embryo (GO:0008595)3.97612376
29extracellular fibril organization (GO:0043206)3.97485220
30metanephric tubule development (GO:0072170)3.94812710
31metanephric nephron tubule development (GO:0072234)3.94812710
32muscle cell migration (GO:0014812)3.94057131
33hindlimb morphogenesis (GO:0035137)3.89902788
34metanephros development (GO:0001656)3.89791302
35negative regulation of metanephros development (GO:0072217)3.87806016
36generation of neurons (GO:0048699)3.86698750
37skeletal muscle organ development (GO:0060538)3.86535025
38mesenchymal to epithelial transition (GO:0060231)3.83049580
39regulation of heart morphogenesis (GO:2000826)3.73855648
40regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.70888440
41glomerular epithelial cell development (GO:0072310)3.69978611
42endocardial cushion morphogenesis (GO:0003203)3.67421903
43cochlea morphogenesis (GO:0090103)3.65423886
44metanephric nephron epithelium development (GO:0072243)3.62337404
45middle ear morphogenesis (GO:0042474)3.60884149
46lung-associated mesenchyme development (GO:0060484)3.58616035
47glomerulus development (GO:0032835)3.55292267
48mesenchyme development (GO:0060485)3.51545480
49positive regulation of gastrulation (GO:2000543)3.51064091
50negative regulation of chondrocyte differentiation (GO:0032331)3.51027246
51regulation of mammary gland epithelial cell proliferation (GO:0033599)3.49607274
52renal filtration (GO:0097205)3.46943466
53regulation of mesenchymal cell apoptotic process (GO:2001053)3.45774156
54regulation of apoptotic process involved in morphogenesis (GO:1902337)3.44649563
55skeletal system morphogenesis (GO:0048705)3.44147323
56negative regulation of axon extension involved in axon guidance (GO:0048843)3.43188816
57nephron tubule formation (GO:0072079)3.39209686
58non-canonical Wnt signaling pathway (GO:0035567)3.36815446
59regulation of organ formation (GO:0003156)3.36655170
60cell proliferation involved in metanephros development (GO:0072203)3.34869917
61protein heterotrimerization (GO:0070208)3.32176084
62glomerular filtration (GO:0003094)3.31629410
63fibril organization (GO:0097435)3.30809890
64collecting duct development (GO:0072044)3.30435435
65hippo signaling (GO:0035329)3.30000354
66hypotonic response (GO:0006971)3.29522461
67cranial nerve morphogenesis (GO:0021602)3.28005972
68mesenchymal cell proliferation (GO:0010463)3.25270059
69embryonic appendage morphogenesis (GO:0035113)3.24042576
70embryonic limb morphogenesis (GO:0030326)3.24042576
71coronary vasculature morphogenesis (GO:0060977)3.23599093
72outflow tract septum morphogenesis (GO:0003148)3.23130549
73mesenchymal cell differentiation involved in renal system development (GO:2001012)3.22643254
74mesenchymal cell differentiation involved in kidney development (GO:0072161)3.22643254
75aorta morphogenesis (GO:0035909)3.22310826
76embryonic skeletal system development (GO:0048706)3.22234858
77collagen fibril organization (GO:0030199)3.22146886
78regulation of cardioblast differentiation (GO:0051890)3.22140859
79cell differentiation involved in metanephros development (GO:0072202)3.20425827
80regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.19585368
81lateral sprouting from an epithelium (GO:0060601)3.15260840
82negative regulation of axon guidance (GO:1902668)3.13982951
83regulation of cell proliferation involved in heart morphogenesis (GO:2000136)3.13046416
84negative regulation of cell fate specification (GO:0009996)3.12338528
85lymph vessel development (GO:0001945)3.12176644
86Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.12109866
87regulation of epithelial cell differentiation involved in kidney development (GO:2000696)3.11524717
88nephron tubule development (GO:0072080)3.11430568
89facial nerve structural organization (GO:0021612)3.10405060
90renal system development (GO:0072001)3.10329914
91G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.09924572
92positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)3.09897239
93establishment of tissue polarity (GO:0007164)3.09505105
94establishment of planar polarity (GO:0001736)3.09505105
95regulation of chondrocyte differentiation (GO:0032330)3.09058478
96negative regulation of embryonic development (GO:0045992)3.08773144
97neuron projection extension involved in neuron projection guidance (GO:1902284)3.08706819
98axon extension involved in axon guidance (GO:0048846)3.08706819
99embryonic organ morphogenesis (GO:0048562)3.08475038
100anterior/posterior pattern specification (GO:0009952)3.07590821
101mammary gland development (GO:0030879)3.07558401
102establishment of apical/basal cell polarity (GO:0035089)3.07550475
103regulation of glomerulus development (GO:0090192)3.07383516
104peripheral nervous system neuron development (GO:0048935)3.07093909
105chondrocyte proliferation (GO:0035988)3.06645317
106embryonic cranial skeleton morphogenesis (GO:0048701)3.06362721
107mesenchyme morphogenesis (GO:0072132)3.05789495
108establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)3.05459396
109appendage morphogenesis (GO:0035107)3.05343699
110limb morphogenesis (GO:0035108)3.05343699
111neuron fate specification (GO:0048665)3.05212890
112positive regulation of chondrocyte differentiation (GO:0032332)3.01623446
113vascular endothelial growth factor signaling pathway (GO:0038084)3.01590340
114cranial nerve structural organization (GO:0021604)3.00959727
115developmental induction (GO:0031128)3.00920884
116regulation of translational termination (GO:0006449)3.00722544
117regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.99813065
118cell surface receptor signaling pathway involved in heart development (GO:0061311)2.99446424
119regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.99277580
120cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.98968476
121establishment or maintenance of monopolar cell polarity (GO:0061339)2.98958052
122establishment of monopolar cell polarity (GO:0061162)2.98958052
123regulation of stem cell maintenance (GO:2000036)2.97300379
124regulation of establishment of planar polarity (GO:0090175)2.96900738
125face development (GO:0060324)2.96770883
126respiratory tube development (GO:0030323)2.96389296
127nephron epithelium development (GO:0072009)2.95450942
128embryonic digit morphogenesis (GO:0042733)2.93372493
129positive regulation of cartilage development (GO:0061036)2.92976671
130branching involved in ureteric bud morphogenesis (GO:0001658)2.92380735
131artery development (GO:0060840)2.91769847
132regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.90864673
133negative regulation of kidney development (GO:0090185)2.85913404
134regulation of mitotic spindle organization (GO:0060236)2.84224227
135cell-cell signaling involved in cell fate commitment (GO:0045168)2.83147248
136protein retention in ER lumen (GO:0006621)2.77578185
137protein maturation by protein folding (GO:0022417)2.73207257
138regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.72053425
139regulation of cartilage development (GO:0061035)2.71834963
140skeletal muscle tissue development (GO:0007519)2.70860638
141Golgi transport vesicle coating (GO:0048200)2.70834341
142COPI coating of Golgi vesicle (GO:0048205)2.70834341
143barbed-end actin filament capping (GO:0051016)2.70454357
144basement membrane organization (GO:0071711)2.70125529
145negative regulation of cartilage development (GO:0061037)2.70093274
146muscle cell proliferation (GO:0033002)2.67987494
147ventricular cardiac muscle cell development (GO:0055015)2.67634776
148pharyngeal system development (GO:0060037)2.67157205
149regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.67021460
150positive regulation of odontogenesis (GO:0042482)2.66540759
151segment specification (GO:0007379)2.66061327
152striated muscle cell proliferation (GO:0014855)2.65682305
153cardiac muscle cell proliferation (GO:0060038)2.65664572
154ganglion development (GO:0061548)2.65629980
155axis elongation (GO:0003401)2.64095424
156protein localization to endosome (GO:0036010)2.61631124
157maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.57190776

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.92637467
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.46098759
3CLOCK_20551151_ChIP-Seq_293T_Human3.39712188
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.27754330
5CHD7_19251738_ChIP-ChIP_MESCs_Mouse3.15594623
6RARG_19884340_ChIP-ChIP_MEFs_Mouse3.07196554
7TRIM28_21343339_ChIP-Seq_HEK293_Human3.00836032
8ESR1_21235772_ChIP-Seq_MCF-7_Human2.81417643
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.81202821
10EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.69333531
11* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.66555210
12PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.52722505
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.52219304
14ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.45043847
15* TP53_20018659_ChIP-ChIP_R1E_Mouse2.36925787
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.34235985
17CBX2_27304074_Chip-Seq_ESCs_Mouse2.27785788
18* CDX2_19796622_ChIP-Seq_MESCs_Mouse2.22908982
19RNF2_18974828_ChIP-Seq_MESCs_Mouse2.22889865
20EZH2_18974828_ChIP-Seq_MESCs_Mouse2.22889865
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.12677194
22NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.11756436
23KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.10532566
24KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.10532566
25KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.10532566
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.05433330
27RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.02464694
28WT1_19549856_ChIP-ChIP_CCG9911_Human1.97844324
29CDX2_20551321_ChIP-Seq_CACO-2_Human1.97220718
30ZFP281_18757296_ChIP-ChIP_E14_Mouse1.94486700
31* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.94322525
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.90374186
33PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.89686211
34SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.87357486
35ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.81490072
36KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.80174273
37NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.78864078
38CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.75467837
39SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.75032807
40EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.74016011
41CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.73603474
42TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.73418103
43LXR_22292898_ChIP-Seq_THP-1_Human1.71254688
44TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70652285
45RACK7_27058665_Chip-Seq_MCF-7_Human1.67569599
46JARID2_20075857_ChIP-Seq_MESCs_Mouse1.67308325
47RING1B_27294783_Chip-Seq_NPCs_Mouse1.66763762
48FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.65101115
49ISL1_27105846_Chip-Seq_CPCs_Mouse1.63143122
50SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.58276724
51HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.57384675
52TET1_21451524_ChIP-Seq_MESCs_Mouse1.55492050
53DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.54661831
54POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.54023483
55POU5F1_16153702_ChIP-ChIP_HESCs_Human1.50635925
56SALL4_18804426_ChIP-ChIP_XEN_Mouse1.50568064
57TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.50351731
58* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.50098571
59ELK3_25401928_ChIP-Seq_HUVEC_Human1.49861742
60KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.49639970
61* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.48577109
62ERG_21242973_ChIP-ChIP_JURKAT_Human1.43319880
63SOX2_20726797_ChIP-Seq_SW620_Human1.43195284
64* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.40225697
65E2F7_22180533_ChIP-Seq_HELA_Human1.38044479
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.37218364
67FOXM1_23109430_ChIP-Seq_U2OS_Human1.36079536
68XRN2_22483619_ChIP-Seq_HELA_Human1.34463018
69CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.33350773
70RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.33274162
71TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.33149689
72HIF1A_21447827_ChIP-Seq_MCF-7_Human1.32355916
73RING1B_27294783_Chip-Seq_ESCs_Mouse1.30800464
74FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.29978878
75STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.27985691
76NFIB_24661679_ChIP-Seq_LUNG_Mouse1.27693090
77STAT6_21828071_ChIP-Seq_BEAS2B_Human1.27525830
78AR_21909140_ChIP-Seq_LNCAP_Human1.26584821
79SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.26203054
80SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.26203054
81SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.24542349
82MYC_18555785_ChIP-Seq_MESCs_Mouse1.21948781
83P300_27058665_Chip-Seq_ZR-75-30cells_Human1.21797748
84SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.21507478
85ESR1_15608294_ChIP-ChIP_MCF-7_Human1.21225831
86EP300_21415370_ChIP-Seq_HL-1_Mouse1.20604709
87TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.20338387
88CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.19936275
89MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.19396119
90CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.18368640
91TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16410845
92ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16121521
93* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.15993024
94THAP11_20581084_ChIP-Seq_MESCs_Mouse1.15804403
95WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15373950
96GATA6_25053715_ChIP-Seq_YYC3_Human1.13903804
97SOX2_18555785_ChIP-Seq_MESCs_Mouse1.13693382
98CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.13195426
99* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.13171719
100ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.12936633
101SMC1_22415368_ChIP-Seq_MEFs_Mouse1.12865269
102NANOG_16153702_ChIP-ChIP_HESCs_Human1.12528153
103SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.12313623
104ESR1_20079471_ChIP-ChIP_T-47D_Human1.11394217
105* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.10274065
106CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.10268905
107SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.10083247
108SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.09834109
109KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.09574701
110PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.09312849
111DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.08488640
112KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08393197
113MYC_18358816_ChIP-ChIP_MESCs_Mouse1.08136915
114KDM2B_26808549_Chip-Seq_SUP-B15_Human1.08081430
115TCF3_18692474_ChIP-Seq_MEFs_Mouse1.07448879
116CREB1_26743006_Chip-Seq_LNCaP_Human1.06114992
117SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05873530
118TP53_22127205_ChIP-Seq_IMR90_Human1.05192687
119* EZH2_27294783_Chip-Seq_ESCs_Mouse1.05093058
120UBF1/2_26484160_Chip-Seq_HMECs_Human1.04889214
121NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.04831289
122UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.04639038
123EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.04615448
124RNF2_27304074_Chip-Seq_ESCs_Mouse1.04533842
125TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04313913
126ATF3_27146783_Chip-Seq_COLON_Human1.03743987
127* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03565451
128EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02956687
129OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.01343940
130SMC3_22415368_ChIP-Seq_MEFs_Mouse1.01274658
131KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.00726464
132KDM2B_26808549_Chip-Seq_K562_Human0.99213817
133CHD1_26751641_Chip-Seq_LNCaP_Human0.98304568
134HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97783705
135TCF4_18268006_ChIP-ChIP_LS174T_Human0.97183435
136TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.95740009

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005623_abnormal_meninges_morphology3.42778868
2MP0000537_abnormal_urethra_morphology3.09496955
3MP0005171_absent_coat_pigmentation3.03642506
4MP0009053_abnormal_anal_canal3.00833024
5MP0003385_abnormal_body_wall2.97362107
6MP0005257_abnormal_intraocular_pressure2.97069714
7MP0010030_abnormal_orbit_morphology2.96353690
8MP0000534_abnormal_ureter_morphology2.89409396
9MP0005503_abnormal_tendon_morphology2.84043871
10MP0004272_abnormal_basement_membrane2.82554723
11MP0002877_abnormal_melanocyte_morpholog2.78206329
12MP0008438_abnormal_cutaneous_collagen2.71852535
13MP0009250_abnormal_appendicular_skeleto2.66223919
14MP0003942_abnormal_urinary_system2.61384869
15MP0000516_abnormal_urinary_system2.58564926
16MP0005367_renal/urinary_system_phenotyp2.58564926
17MP0003123_paternal_imprinting2.48317436
18MP0002249_abnormal_larynx_morphology2.42859660
19MP0002932_abnormal_joint_morphology2.39981012
20MP0000049_abnormal_middle_ear2.31755512
21MP0003705_abnormal_hypodermis_morpholog2.22046451
22MP0003937_abnormal_limbs/digits/tail_de2.14983029
23MP0003315_abnormal_perineum_morphology2.12477642
24MP0006054_spinal_hemorrhage2.08741608
25MP0010234_abnormal_vibrissa_follicle2.00240448
26MP0003122_maternal_imprinting1.97940544
27MP0003941_abnormal_skin_development1.91713973
28MP0005670_abnormal_white_adipose1.90180353
29MP0001958_emphysema1.82123552
30MP0002282_abnormal_trachea_morphology1.81517297
31MP0000759_abnormal_skeletal_muscle1.72269549
32MP0005377_hearing/vestibular/ear_phenot1.69320980
33MP0003878_abnormal_ear_physiology1.69320980
34MP0004858_abnormal_nervous_system1.62109919
35MP0001756_abnormal_urination1.60336521
36MP0005275_abnormal_skin_tensile1.56700992
37* MP0002114_abnormal_axial_skeleton1.54165110
38MP0000462_abnormal_digestive_system1.50818029
39MP0003121_genomic_imprinting1.50403752
40MP0000733_abnormal_muscle_development1.48853452
41MP0003755_abnormal_palate_morphology1.45891276
42MP0001879_abnormal_lymphatic_vessel1.43318739
43MP0004233_abnormal_muscle_weight1.41288397
44MP0003115_abnormal_respiratory_system1.40429283
45MP0003935_abnormal_craniofacial_develop1.39148737
46MP0003938_abnormal_ear_development1.38501070
47MP0000678_abnormal_parathyroid_gland1.37632602
48MP0002108_abnormal_muscle_morphology1.36488161
49MP0003567_abnormal_fetal_cardiomyocyte1.34391596
50MP0002115_abnormal_skeleton_extremities1.34093694
51MP0002111_abnormal_tail_morphology1.32427763
52MP0005409_darkened_coat_color1.30517470
53MP0004185_abnormal_adipocyte_glucose1.27732994
54MP0000762_abnormal_tongue_morphology1.26108743
55MP0005508_abnormal_skeleton_morphology1.25620425
56MP0002109_abnormal_limb_morphology1.24863480
57* MP0002116_abnormal_craniofacial_bone1.24773123
58MP0010386_abnormal_urinary_bladder1.20167711
59MP0005666_abnormal_adipose_tissue1.19451949
60MP0003566_abnormal_cell_adhesion1.19146905
61MP0000767_abnormal_smooth_muscle1.17479731
62MP0000163_abnormal_cartilage_morphology1.17367603
63MP0000428_abnormal_craniofacial_morphol1.16408936
64MP0000566_synostosis1.14584257
65MP0003119_abnormal_digestive_system1.14198306
66MP0004043_abnormal_pH_regulation1.13893660
67MP0009780_abnormal_chondrocyte_physiolo1.13826437
68MP0000749_muscle_degeneration1.11341742
69MP0005408_hypopigmentation1.07371186
70MP0003136_yellow_coat_color1.06268324
71MP0005375_adipose_tissue_phenotype1.05927853
72MP0002160_abnormal_reproductive_system1.05581609
73MP0000467_abnormal_esophagus_morphology1.05560681
74MP0000003_abnormal_adipose_tissue1.04014045
75MP0001299_abnormal_eye_distance/1.03837979
76MP0002060_abnormal_skin_morphology1.03707776
77MP0002233_abnormal_nose_morphology1.02931622
78MP0000432_abnormal_head_morphology1.02620275
79MP0001270_distended_abdomen1.02410178
80MP0002085_abnormal_embryonic_tissue0.99805688
81MP0000681_abnormal_thyroid_gland0.99803389
82MP0004197_abnormal_fetal_growth/weight/0.99036271
83MP0006138_congestive_heart_failure0.98420541
84MP0002113_abnormal_skeleton_development0.96018372
85MP0002177_abnormal_outer_ear0.95712352
86MP0005248_abnormal_Harderian_gland0.95489552
87MP0000383_abnormal_hair_follicle0.94966607
88MP0000538_abnormal_urinary_bladder0.94930474
89MP0003936_abnormal_reproductive_system0.93356287
90MP0001849_ear_inflammation0.92239098
91MP0002697_abnormal_eye_size0.90354597
92MP0002135_abnormal_kidney_morphology0.90010389
93MP0010368_abnormal_lymphatic_system0.89403294
94MP0003091_abnormal_cell_migration0.88249482
95MP0002896_abnormal_bone_mineralization0.85174970
96MP0001188_hyperpigmentation0.84431804
97MP0003283_abnormal_digestive_organ0.84293281
98MP0000013_abnormal_adipose_tissue0.83921175
99MP0002084_abnormal_developmental_patter0.83673118
100MP0000613_abnormal_salivary_gland0.83437629
101MP0004134_abnormal_chest_morphology0.82175769
102MP0003279_aneurysm0.81996333
103MP0010678_abnormal_skin_adnexa0.81590239
104MP0002938_white_spotting0.81257505
105MP0002092_abnormal_eye_morphology0.80413704
106MP0002136_abnormal_kidney_physiology0.80254853
107MP0004087_abnormal_muscle_fiber0.80174533
108MP0009643_abnormal_urine_homeostasis0.79863960
109MP0002269_muscular_atrophy0.79812779
110MP0009672_abnormal_birth_weight0.78744354
111MP0002751_abnormal_autonomic_nervous0.77460142
112MP0001346_abnormal_lacrimal_gland0.76133042
113MP0001293_anophthalmia0.75922937
114MP0000751_myopathy0.75846879
115MP0005330_cardiomyopathy0.75698487
116MP0002925_abnormal_cardiovascular_devel0.74503191
117MP0008932_abnormal_embryonic_tissue0.73518160
118MP0005369_muscle_phenotype0.72336365
119MP0005076_abnormal_cell_differentiation0.71923212
120MP0005193_abnormal_anterior_eye0.71603215
121MP0001765_abnormal_ion_homeostasis0.71091511
122MP0003111_abnormal_nucleus_morphology0.70790113
123MP0003077_abnormal_cell_cycle0.70330089
124MP0001340_abnormal_eyelid_morphology0.70302378
125MP0005187_abnormal_penis_morphology0.70133682
126MP0002081_perinatal_lethality0.67600704
127MP0000747_muscle_weakness0.67505033
128MP0003861_abnormal_nervous_system0.66923296
129MP0002184_abnormal_innervation0.66565571
130MP0001915_intracranial_hemorrhage0.66516056
131MP0000372_irregular_coat_pigmentation0.66433539
132MP0001614_abnormal_blood_vessel0.66401210
133MP0002098_abnormal_vibrissa_morphology0.65210181
134MP0003950_abnormal_plasma_membrane0.64558238
135MP0001661_extended_life_span0.64003484
136MP0005197_abnormal_uvea_morphology0.63842209
137MP0000955_abnormal_spinal_cord0.62719990

Predicted human phenotypes

RankGene SetZ-score
1Aortic aneurysm (HP:0004942)4.60325155
2Shawl scrotum (HP:0000049)3.76625163
3Abnormality of the phalanges of the hallux (HP:0010057)3.73344673
4Aortic dissection (HP:0002647)3.69857376
5Short 4th metacarpal (HP:0010044)3.56761371
6Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.56761371
7Renal duplication (HP:0000075)3.37358371
8Abnormality of the 4th metacarpal (HP:0010012)3.32120723
9Focal segmental glomerulosclerosis (HP:0000097)3.03165348
10Arterial tortuosity (HP:0005116)3.01186575
11Metabolic alkalosis (HP:0200114)2.97907182
12Vascular tortuosity (HP:0004948)2.97686215
13Vertebral compression fractures (HP:0002953)2.93004032
14Ankle contracture (HP:0006466)2.92017223
15Abnormality of the distal phalanges of the toes (HP:0010182)2.88958831
16Midline defect of the nose (HP:0004122)2.87152267
17Down-sloping shoulders (HP:0200021)2.86340212
18Atrophic scars (HP:0001075)2.85460325
19Bicornuate uterus (HP:0000813)2.84098620
20Increased circulating renin level (HP:0000848)2.78388586
21Fragile skin (HP:0001030)2.75330279
22Calcaneovalgus deformity (HP:0001848)2.73046330
23Stridor (HP:0010307)2.68632038
24Hyperacusis (HP:0010780)2.65861846
25Scapular winging (HP:0003691)2.65352061
26White forelock (HP:0002211)2.64566081
27Genu recurvatum (HP:0002816)2.61319809
28Shallow orbits (HP:0000586)2.60030947
29Potter facies (HP:0002009)2.57685050
30Facial shape deformation (HP:0011334)2.57685050
31Hip contracture (HP:0003273)2.57646699
32Glomerulosclerosis (HP:0000096)2.57512656
33Type 1 muscle fiber predominance (HP:0003803)2.54467207
34Ulnar bowing (HP:0003031)2.52759664
35Mesangial abnormality (HP:0001966)2.52539584
36Broad metatarsal (HP:0001783)2.52249410
37Patchy hypopigmentation of hair (HP:0011365)2.49375785
38Short clavicles (HP:0000894)2.45231933
39Back pain (HP:0003418)2.44976181
40Hypokalemic alkalosis (HP:0001949)2.44425184
41Rectal prolapse (HP:0002035)2.44289976
42Deformed tarsal bones (HP:0008119)2.44196244
43Lip pit (HP:0100267)2.42458577
44Mitral valve prolapse (HP:0001634)2.40556885
45Abnormality of the calcaneus (HP:0008364)2.40348552
46Abnormality of chloride homeostasis (HP:0011422)2.38297995
47Hyperactive renin-angiotensin system (HP:0000841)2.38174576
48Follicular hyperkeratosis (HP:0007502)2.37564046
49Abnormality of the fetal cardiovascular system (HP:0010948)2.35344366
50Abnormal umbilical cord blood vessels (HP:0011403)2.35344366
51Single umbilical artery (HP:0001195)2.35344366
52Mesomelia (HP:0003027)2.34350893
53Hallux valgus (HP:0001822)2.32525377
54Delayed cranial suture closure (HP:0000270)2.30616717
55Osteolytic defects of the hand bones (HP:0009699)2.30502761
56Osteolytic defects of the phalanges of the hand (HP:0009771)2.30502761
57Deviation of the hallux (HP:0010051)2.30401932
58Sprengel anomaly (HP:0000912)2.28720999
59Aplasia/Hypoplasia of the clavicles (HP:0006710)2.25641810
60Coronal craniosynostosis (HP:0004440)2.25346804
61Premature rupture of membranes (HP:0001788)2.25252117
62Preauricular pit (HP:0004467)2.25171753
63Periauricular skin pits (HP:0100277)2.25171753
64Synostosis of carpal bones (HP:0005048)2.23405954
65Broad toe (HP:0001837)2.23341199
66Broad distal phalanx of finger (HP:0009836)2.23163337
67Bowel diverticulosis (HP:0005222)2.22881686
68Lymphangioma (HP:0100764)2.22304106
69Blue sclerae (HP:0000592)2.22188603
70Increased connective tissue (HP:0009025)2.20484547
71Abnormal ossification of hand bones (HP:0005921)2.20216012
72Knee flexion contracture (HP:0006380)2.17890453
73Hyperextensible skin (HP:0000974)2.16888769
74Turricephaly (HP:0000262)2.13819451
75Reduced subcutaneous adipose tissue (HP:0003758)2.13696207
76Broad face (HP:0000283)2.13312820
77Camptodactyly of toe (HP:0001836)2.12673067
78Abnormality of the umbilical cord (HP:0010881)2.11697301
79Cervical subluxation (HP:0003308)2.11134445
80Soft skin (HP:0000977)2.06905603
81Protrusio acetabuli (HP:0003179)2.03107401
82Wormian bones (HP:0002645)2.02902357
83Long toe (HP:0010511)2.02843121
84Hypomagnesemia (HP:0002917)2.02667324
85Polyuria (HP:0000103)2.01412947
86Tubular atrophy (HP:0000092)2.01167652
87Hypoplasia of the iris (HP:0007676)2.00289734
88Carpal synostosis (HP:0009702)1.98136957
89Abnormality of the shoulder girdle musculature (HP:0001435)1.97590038
90Hypercalciuria (HP:0002150)1.96832077
91High anterior hairline (HP:0009890)1.95573237
92Abnormality of dentin (HP:0010299)1.95533509
93Partial duplication of the phalanx of hand (HP:0009999)1.95036406
94Adducted thumb (HP:0001181)1.94912369
95Wide anterior fontanel (HP:0000260)1.94581070
96Short nail (HP:0001799)1.93642525
97Cerebral aneurysm (HP:0004944)1.92618221
98Bladder diverticulum (HP:0000015)1.91848131
99Abnormal urine output (HP:0012590)1.91837882
100Persistence of primary teeth (HP:0006335)1.89670559
101Infantile muscular hypotonia (HP:0008947)1.89552840
102Abnormality of the parietal bone (HP:0002696)1.88982997
103Metaphyseal cupping (HP:0003021)1.88221333
104Muscle fiber splitting (HP:0003555)1.87956074
105Chin dimple (HP:0010751)1.87771061
106Elbow flexion contracture (HP:0002987)1.86190436
107Limited hip movement (HP:0008800)1.86135812
108Aneurysm (HP:0002617)1.85542669
109Abnormality of the distal phalanx of the thumb (HP:0009617)1.85005874
110Ectopia lentis (HP:0001083)1.84784542
111Bell-shaped thorax (HP:0001591)1.83670292
112Broad thumb (HP:0011304)1.83452013
113Joint laxity (HP:0001388)1.83093974
114Short hallux (HP:0010109)1.81626772
115Renal dysplasia (HP:0000110)1.81339254
116Preaxial foot polydactyly (HP:0001841)1.80984235
117Synostosis involving bones of the lower limbs (HP:0009138)1.80155604
118Synostosis involving bones of the feet (HP:0009140)1.80155604
119Abnormality of the anterior chamber (HP:0000593)1.80047045
120Abnormality of magnesium homeostasis (HP:0004921)1.79852779
121Abnormality of the 2nd finger (HP:0004100)1.79590147
122Insomnia (HP:0100785)1.79438126
123Short middle phalanx of the 5th finger (HP:0004220)1.78413817
124Abnormality of renin-angiotensin system (HP:0000847)1.78311091
125Biconcave vertebral bodies (HP:0004586)1.77386254
126Hypokalemia (HP:0002900)1.77281477
127Disproportionate tall stature (HP:0001519)1.77036670
128Dislocated radial head (HP:0003083)1.76744751
129Pulmonary artery stenosis (HP:0004415)1.76158799
130Synostosis involving bones of the hand (HP:0004278)1.76095029
131Polydipsia (HP:0001959)1.76068094
132Abnormal drinking behavior (HP:0030082)1.76068094
133Dilatation of the ascending aorta (HP:0005111)1.75476675
134Renovascular hypertension (HP:0100817)1.74745530
135Radial bowing (HP:0002986)1.74392520
136Malnutrition (HP:0004395)1.73574630
137Concave nail (HP:0001598)1.73519490
138Joint contractures involving the joints of the feet (HP:0100492)1.73033030
139Flexion contracture of toe (HP:0005830)1.73033030
140Anal stenosis (HP:0002025)1.72918179
141Tarsal synostosis (HP:0008368)1.72518511
142Arnold-Chiari malformation (HP:0002308)1.72324504
143Atresia of the external auditory canal (HP:0000413)1.70074440
144Selective tooth agenesis (HP:0001592)1.69924090
145Wrist flexion contracture (HP:0001239)1.69724456
146Buphthalmos (HP:0000557)1.68730099
147Neoplasm of the heart (HP:0100544)1.68721774
148Spinal rigidity (HP:0003306)1.67862243
149Abnormality of the radial head (HP:0003995)1.67318290
150Renal salt wasting (HP:0000127)1.67184498
151Neonatal short-limb short stature (HP:0008921)1.67009922
152Hypoventilation (HP:0002791)1.66899978
153Abnormality of renal excretion (HP:0011036)1.66783784
154Germ cell neoplasia (HP:0100728)1.65635103
155Broad hallux (HP:0010055)1.65458860
156Abnormality of carpal bone ossification (HP:0006257)1.65362222
157Venous abnormality (HP:0002624)1.65298356
158Spinal cord lesions (HP:0100561)1.63486633
159Syringomyelia (HP:0003396)1.63486633
160Increased variability in muscle fiber diameter (HP:0003557)1.63265664
161Abnormal number of incisors (HP:0011064)1.62736010
162Trismus (HP:0000211)1.62379066
163Distal lower limb amyotrophy (HP:0008944)1.62352425
164Overriding aorta (HP:0002623)1.61832231
165Abnormal hand bone ossification (HP:0010660)1.61632958
166Distal upper limb amyotrophy (HP:0007149)1.59873602
167Upper limb amyotrophy (HP:0009129)1.59873602
168Occipital encephalocele (HP:0002085)1.59266472

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK44.19295948
2MYLK4.05551150
3EPHB23.80865642
4AKT33.66115419
5TTN3.14065620
6LATS12.78204677
7STK392.75707841
8TRIB32.47224897
9TLK12.32984301
10BUB12.31737210
11MAP3K32.28207303
12SMG12.24286030
13PDGFRA2.21375266
14OXSR12.13668144
15LATS22.10245977
16PAK22.08435855
17NME22.05845710
18NTRK11.98660788
19MKNK11.83155377
20PIK3CA1.80478791
21ERBB31.79820680
22WNK31.79778618
23CDK121.68809259
24VRK21.64974804
25WNK11.64095908
26PTK61.59227143
27EEF2K1.46821758
28LIMK11.43693754
29STK38L1.41853758
30DDR21.37327184
31MOS1.35681195
32LMTK21.33632798
33ERBB41.29869125
34TIE11.27685751
35IRAK31.27607018
36FER1.24072217
37SIK31.21270918
38SRPK11.20307667
39PAK41.18054787
40MST1R1.14240806
41DMPK1.13656368
42MKNK21.11444537
43MET1.11194738
44FGFR11.10684567
45TTK1.04373553
46BRSK11.03568471
47MAP3K101.03025780
48TGFBR11.02676532
49CAMK1G1.00897373
50TGFBR20.99792842
51EPHA20.99497810
52CAMK1D0.99041797
53NEK10.95369201
54PDK20.94712874
55MAP3K60.94200363
56PTK20.93548211
57PLK40.93357056
58KDR0.92513829
59PAK60.91737330
60CSNK1G30.90390573
61STK380.89610480
62PRKCI0.88997308
63STK30.86397924
64MAP2K20.85457254
65RPS6KB20.84257339
66NEK90.84244480
67ILK0.84059586
68WEE10.83924982
69PKN20.83734568
70MTOR0.83577729
71TAF10.83322288
72PAK10.81861580
73BMX0.78629650
74LRRK20.78239540
75PHKG10.77715321
76PHKG20.77715321
77DYRK1A0.77405543
78SGK4940.75972817
79SGK2230.75972817
80MARK10.75956071
81TESK10.75177500
82TSSK60.74817722
83ROCK10.73595070
84SIK10.71755028
85FGFR40.69249893
86FGFR20.68995256
87FRK0.68558198
88BRAF0.67218109
89CDK180.66794211
90ICK0.66774140
91RIPK10.66420224
92GSK3A0.66278522
93MAP3K80.64107009
94PRPF4B0.63399532
95CDK11A0.62876478
96CDK150.62717587
97CSNK1G20.59529857
98TRPM70.58737711
99DAPK30.56517454
100CDK80.54998754
101PIK3CG0.54369896
102SGK30.53844788
103PTK2B0.53685689
104CSNK1E0.53468194
105ARAF0.52738335
106PIM20.52366291
107RET0.52148561
108NEK20.52128462
109ROCK20.52018762
110CDK140.51887721
111RPS6KA20.51702480
112ERN10.50878550
113CSNK1A1L0.50081388
114PDGFRB0.50071599
115PASK0.48622764
116TESK20.48479993
117CHEK20.47129956
118MAP2K30.46116012
119PKN10.46109465
120AURKA0.46087217
121AURKB0.46026376
122CDK90.44884803
123EPHB10.44351901
124ERBB20.43905018
125MAPKAPK20.43657059
126BCR0.43562914
127CHEK10.42396259
128CDK70.40124946
129PRKD30.39896267
130SRC0.39750454
131BRD40.38767426
132CLK10.37768428
133MAPK110.36782395
134YES10.36183683
135CDC42BPA0.36170302
136PRKCH0.35912103
137ABL20.35861670
138CAMK2G0.35776526
139AKT20.35706836
140RPS6KL10.34946505
141RPS6KC10.34946505
142PRKD10.34153420
143INSR0.32700066
144DYRK1B0.32131202
145CDC70.30648203
146SGK20.30520218
147PRKD20.29018457
148PAK30.28398798
149CSNK1G10.26285239

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052174.08236540
2Hedgehog signaling pathway_Homo sapiens_hsa043403.35128989
3Hippo signaling pathway_Homo sapiens_hsa043902.67962667
4ECM-receptor interaction_Homo sapiens_hsa045122.58640837
5Tight junction_Homo sapiens_hsa045302.15634771
6Cyanoamino acid metabolism_Homo sapiens_hsa004602.08844384
7Propanoate metabolism_Homo sapiens_hsa006402.07019662
8Focal adhesion_Homo sapiens_hsa045102.06353143
9Sulfur metabolism_Homo sapiens_hsa009202.03614628
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.98847743
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.97866944
12Protein digestion and absorption_Homo sapiens_hsa049741.97247927
13Proteoglycans in cancer_Homo sapiens_hsa052051.90029433
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.88875951
15Adherens junction_Homo sapiens_hsa045201.85872528
16Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.83421499
17Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.79273819
18Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.68767791
19TGF-beta signaling pathway_Homo sapiens_hsa043501.66304833
20Axon guidance_Homo sapiens_hsa043601.65724115
21Melanogenesis_Homo sapiens_hsa049161.55653488
22Bladder cancer_Homo sapiens_hsa052191.54667862
23MicroRNAs in cancer_Homo sapiens_hsa052061.50513194
24Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.49506364
25DNA replication_Homo sapiens_hsa030301.46999489
26Biosynthesis of amino acids_Homo sapiens_hsa012301.45308357
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.43008407
28Wnt signaling pathway_Homo sapiens_hsa043101.40447709
29Small cell lung cancer_Homo sapiens_hsa052221.40334204
30Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.39629925
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.34040632
32Notch signaling pathway_Homo sapiens_hsa043301.32597728
33Pentose phosphate pathway_Homo sapiens_hsa000301.31384312
34Glutathione metabolism_Homo sapiens_hsa004801.30391149
35Fatty acid metabolism_Homo sapiens_hsa012121.27564319
36Pyruvate metabolism_Homo sapiens_hsa006201.24612965
37Lysine degradation_Homo sapiens_hsa003101.23882330
38Fructose and mannose metabolism_Homo sapiens_hsa000511.21447733
39Prostate cancer_Homo sapiens_hsa052151.20938975
40Thyroid hormone signaling pathway_Homo sapiens_hsa049191.20046185
41Non-small cell lung cancer_Homo sapiens_hsa052231.15782811
42Melanoma_Homo sapiens_hsa052181.13872830
43Spliceosome_Homo sapiens_hsa030401.11558274
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.11121870
45Pathways in cancer_Homo sapiens_hsa052001.10245041
46mRNA surveillance pathway_Homo sapiens_hsa030151.09473469
47Arachidonic acid metabolism_Homo sapiens_hsa005901.09044209
48PPAR signaling pathway_Homo sapiens_hsa033201.07230631
49Fatty acid degradation_Homo sapiens_hsa000711.06785781
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.06287999
51Butanoate metabolism_Homo sapiens_hsa006501.05696184
52Endometrial cancer_Homo sapiens_hsa052131.04602457
53Leukocyte transendothelial migration_Homo sapiens_hsa046701.03321807
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.01052843
55Vascular smooth muscle contraction_Homo sapiens_hsa042701.00171575
56PI3K-Akt signaling pathway_Homo sapiens_hsa041510.99826230
57Vibrio cholerae infection_Homo sapiens_hsa051100.97622790
58Glycosaminoglycan degradation_Homo sapiens_hsa005310.97238945
59Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.96948297
60Thyroid cancer_Homo sapiens_hsa052160.94113612
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.92405589
62p53 signaling pathway_Homo sapiens_hsa041150.91880972
63Phenylalanine metabolism_Homo sapiens_hsa003600.91421224
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.90046880
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.89645236
66Base excision repair_Homo sapiens_hsa034100.89537156
67Insulin signaling pathway_Homo sapiens_hsa049100.88354263
68Mineral absorption_Homo sapiens_hsa049780.88039474
69HTLV-I infection_Homo sapiens_hsa051660.87066454
70Other glycan degradation_Homo sapiens_hsa005110.86807307
71Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.86480497
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86122193
73Sulfur relay system_Homo sapiens_hsa041220.85028768
74Chronic myeloid leukemia_Homo sapiens_hsa052200.84721774
75Nucleotide excision repair_Homo sapiens_hsa034200.83652011
76Amoebiasis_Homo sapiens_hsa051460.81163262
77AMPK signaling pathway_Homo sapiens_hsa041520.79413667
78Longevity regulating pathway - mammal_Homo sapiens_hsa042110.78512168
79Prion diseases_Homo sapiens_hsa050200.78434960
80Thyroid hormone synthesis_Homo sapiens_hsa049180.76529098
81Galactose metabolism_Homo sapiens_hsa000520.76347340
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75529242
83Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.72816458
84Glycerolipid metabolism_Homo sapiens_hsa005610.71839115
85Rap1 signaling pathway_Homo sapiens_hsa040150.71233776
86Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70977206
87Fatty acid elongation_Homo sapiens_hsa000620.69963473
88VEGF signaling pathway_Homo sapiens_hsa043700.69371543
89Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.67692935
90Dilated cardiomyopathy_Homo sapiens_hsa054140.67619346
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66877067
92Renin-angiotensin system_Homo sapiens_hsa046140.66774669
93Carbon metabolism_Homo sapiens_hsa012000.65636330
94Cell cycle_Homo sapiens_hsa041100.64930576
95Tyrosine metabolism_Homo sapiens_hsa003500.64150305
96Pyrimidine metabolism_Homo sapiens_hsa002400.64053273
97Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.63642538
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.62868029
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61607568
100Glucagon signaling pathway_Homo sapiens_hsa049220.60809469
101Central carbon metabolism in cancer_Homo sapiens_hsa052300.60019978
102Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59977645
103Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57832529
104beta-Alanine metabolism_Homo sapiens_hsa004100.57365939
105ErbB signaling pathway_Homo sapiens_hsa040120.54835659
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54487089
107Systemic lupus erythematosus_Homo sapiens_hsa053220.53220752
108Choline metabolism in cancer_Homo sapiens_hsa052310.51689003
109Renal cell carcinoma_Homo sapiens_hsa052110.50732354
110Mismatch repair_Homo sapiens_hsa034300.50213038
111Oocyte meiosis_Homo sapiens_hsa041140.49952615
112Glioma_Homo sapiens_hsa052140.49080114
113Arginine and proline metabolism_Homo sapiens_hsa003300.49017693
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48614898
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.47294945
116Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46896560
117Endocytosis_Homo sapiens_hsa041440.46584367
118Ovarian steroidogenesis_Homo sapiens_hsa049130.46295087
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46162511
120Gap junction_Homo sapiens_hsa045400.46127541
121Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46066893
122Ribosome_Homo sapiens_hsa030100.44444118
123Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.44064506
124Insulin resistance_Homo sapiens_hsa049310.43824683
125Tryptophan metabolism_Homo sapiens_hsa003800.43733166
126One carbon pool by folate_Homo sapiens_hsa006700.42746473
127Viral myocarditis_Homo sapiens_hsa054160.42024708
128Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40099697
129Pancreatic cancer_Homo sapiens_hsa052120.38830340
130cGMP-PKG signaling pathway_Homo sapiens_hsa040220.38799787
131HIF-1 signaling pathway_Homo sapiens_hsa040660.37162023
132Viral carcinogenesis_Homo sapiens_hsa052030.36330843
133RNA transport_Homo sapiens_hsa030130.34335711
134Colorectal cancer_Homo sapiens_hsa052100.33297239
135N-Glycan biosynthesis_Homo sapiens_hsa005100.33244533

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