HOXC9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of systemic arterial blood pressure (GO:0003085)6.14478652
2muscle cell fate commitment (GO:0042693)5.03190372
3limb bud formation (GO:0060174)4.83117119
4DNA replication checkpoint (GO:0000076)4.79546036
5axon ensheathment in central nervous system (GO:0032291)4.59744606
6central nervous system myelination (GO:0022010)4.59744606
7regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.57600301
8ribosomal small subunit biogenesis (GO:0042274)4.45284128
9prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060524.12106761
10tooth mineralization (GO:0034505)4.03711348
11neuron cell-cell adhesion (GO:0007158)4.01174877
12outflow tract septum morphogenesis (GO:0003148)4.00142774
13long-chain fatty acid biosynthetic process (GO:0042759)3.93060889
14presynaptic membrane assembly (GO:0097105)3.87917725
15kinetochore organization (GO:0051383)3.81853272
16outer ear morphogenesis (GO:0042473)3.81247608
17cerebral cortex radially oriented cell migration (GO:0021799)3.76482117
18regulation of secondary heart field cardioblast proliferation (GO:0003266)3.76397540
19regulation of cardioblast proliferation (GO:0003264)3.76397540
20presynaptic membrane organization (GO:0097090)3.65638699
21pharyngeal system development (GO:0060037)3.64103349
22kinetochore assembly (GO:0051382)3.62826556
23regulation of mammary gland epithelial cell proliferation (GO:0033599)3.62305638
24cranial nerve morphogenesis (GO:0021602)3.48153291
25endocardial cushion development (GO:0003197)3.45485961
26maturation of SSU-rRNA (GO:0030490)3.44206484
27embryonic skeletal joint morphogenesis (GO:0060272)3.44096946
28lateral sprouting from an epithelium (GO:0060601)3.42025021
29muscle organ morphogenesis (GO:0048644)3.41661486
30replicative senescence (GO:0090399)3.40918111
31thyroid gland development (GO:0030878)3.39789034
32snRNA transcription (GO:0009301)3.39672449
33mesenchymal cell differentiation involved in renal system development (GO:2001012)3.36967769
34mesenchymal cell differentiation involved in kidney development (GO:0072161)3.36967769
35keratinocyte development (GO:0003334)3.36105617
36positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.33049890
37regulation of timing of cell differentiation (GO:0048505)3.31575697
38lymph vessel development (GO:0001945)3.30529134
39neuron remodeling (GO:0016322)3.29354741
40pseudouridine synthesis (GO:0001522)3.24460492
41postsynaptic membrane organization (GO:0001941)3.23489234
42sympathetic nervous system development (GO:0048485)3.20361798
43negative regulation of synaptic transmission, GABAergic (GO:0032229)3.20224293
44uterus development (GO:0060065)3.19738241
45ribosome biogenesis (GO:0042254)3.19140313
46mitotic G1 DNA damage checkpoint (GO:0031571)3.18754332
47replication fork processing (GO:0031297)3.17963820
48oxidative phosphorylation (GO:0006119)3.17945925
49negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.17488204
50ribonucleoprotein complex biogenesis (GO:0022613)3.15862257
51regulation of heart morphogenesis (GO:2000826)3.12853963
52short-term memory (GO:0007614)3.10150714
53negative regulation of protein localization to cell surface (GO:2000009)3.07766779
54righting reflex (GO:0060013)3.07286966
55deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.07132547
56peptidyl-histidine modification (GO:0018202)3.05538109
57middle ear morphogenesis (GO:0042474)3.04419255
58myoblast migration (GO:0051451)3.03757712
59vagina development (GO:0060068)3.03514130
60* skeletal system morphogenesis (GO:0048705)3.03477897
61embryonic skeletal system development (GO:0048706)3.02048309
62maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.01198205
63endosome to pigment granule transport (GO:0043485)3.00309527
64endosome to melanosome transport (GO:0035646)3.00309527
65regulation of development, heterochronic (GO:0040034)2.97453071
66viral mRNA export from host cell nucleus (GO:0046784)2.96172926
67negative regulation of neurotransmitter transport (GO:0051589)2.95751671
68neuron recognition (GO:0008038)2.94922005
69* anterior/posterior pattern specification (GO:0009952)2.94530972
70maturation of 5.8S rRNA (GO:0000460)2.92343952
71positive regulation of fatty acid beta-oxidation (GO:0032000)2.89343350
72mitochondrion morphogenesis (GO:0070584)2.88997793
73ionotropic glutamate receptor signaling pathway (GO:0035235)2.87384284
74mitochondrial RNA metabolic process (GO:0000959)2.86759173
75positive regulation of synapse assembly (GO:0051965)2.86643681
76embryonic viscerocranium morphogenesis (GO:0048703)2.83594168
77ventricular cardiac muscle cell development (GO:0055015)2.83209224
78glucocorticoid receptor signaling pathway (GO:0042921)2.83011079
79proximal/distal pattern formation (GO:0009954)2.82970219
80mesonephros development (GO:0001823)2.82342393
81glutamate receptor signaling pathway (GO:0007215)2.81128167
82G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.80457983
83organ induction (GO:0001759)2.79499136
84negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.79141979
85G1 DNA damage checkpoint (GO:0044783)2.78970269
86cellular response to ATP (GO:0071318)2.78628776
87rRNA processing (GO:0006364)2.78173646
88negative regulation of homotypic cell-cell adhesion (GO:0034111)2.77953382
89retina layer formation (GO:0010842)2.77360845
90pattern specification involved in kidney development (GO:0061004)2.76214607
91mitotic G1/S transition checkpoint (GO:0044819)2.76142854
92rRNA transcription (GO:0009303)2.75009373
93L-amino acid import (GO:0043092)2.74558748
94nonmotile primary cilium assembly (GO:0035058)2.74438354
95cranial nerve structural organization (GO:0021604)2.74191615
96protein K63-linked ubiquitination (GO:0070534)2.73330364
97positive regulation of fatty acid oxidation (GO:0046321)2.72404724
98regulation of pigment cell differentiation (GO:0050932)2.72065845
99regulation of mitochondrial translation (GO:0070129)2.71667229
100mitotic sister chromatid segregation (GO:0000070)2.70999620
101* embryonic skeletal system morphogenesis (GO:0048704)2.70959228
102regulation of inositol phosphate biosynthetic process (GO:0010919)2.70823314
103negative regulation of T cell differentiation in thymus (GO:0033085)2.69914603
104superoxide anion generation (GO:0042554)2.68379046
105negative regulation of myoblast differentiation (GO:0045662)2.66835539
106rRNA metabolic process (GO:0016072)2.66745279
107regulation of histone phosphorylation (GO:0033127)2.66474715
108branching involved in prostate gland morphogenesis (GO:0060442)2.65903212
109cell proliferation in forebrain (GO:0021846)2.65840639
110GDP-mannose metabolic process (GO:0019673)2.65642956
111mitotic metaphase plate congression (GO:0007080)2.65433008
112cellular component biogenesis (GO:0044085)2.62984278
113mitotic chromosome condensation (GO:0007076)2.62242442
114reflex (GO:0060004)2.62061942
115regulation of centrosome cycle (GO:0046605)2.61697233
116regulation of fatty acid beta-oxidation (GO:0031998)2.61415250
117positive regulation of action potential (GO:0045760)2.60910365
118nuclear envelope reassembly (GO:0031468)2.59308047
119mitotic nuclear envelope reassembly (GO:0007084)2.59308047
120opioid receptor signaling pathway (GO:0038003)2.58310689
121regulation of nuclear cell cycle DNA replication (GO:0033262)2.56996561
122tRNA methylation (GO:0030488)2.56557837
123spinal cord motor neuron differentiation (GO:0021522)2.56272641
124regulation of cell aging (GO:0090342)2.56111388
125developmental pigmentation (GO:0048066)2.56075319
126regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.55017448
127transmission of nerve impulse (GO:0019226)2.54516331
128amyloid precursor protein catabolic process (GO:0042987)2.54203857
129aorta morphogenesis (GO:0035909)2.54104516
130intracellular estrogen receptor signaling pathway (GO:0030520)2.53956371
131startle response (GO:0001964)2.53945007
132kidney mesenchyme development (GO:0072074)2.53327439
133regulation of mitotic spindle organization (GO:0060236)2.52959543
134kidney morphogenesis (GO:0060993)2.52610642
135DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.52393026
136negative regulation of execution phase of apoptosis (GO:1900118)2.51456991
137regulation of platelet aggregation (GO:0090330)2.51172062
138negative regulation of cell cycle G2/M phase transition (GO:1902750)2.51076882
139neuronal action potential propagation (GO:0019227)2.50995834
140negative regulation of neurotransmitter secretion (GO:0046929)2.50974030
141positive regulation of protein kinase C signaling (GO:0090037)2.50893857
142ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.50747963
143DNA damage response, signal transduction resulting in transcription (GO:0042772)2.50631403
144regulation of translational termination (GO:0006449)2.50402788
145gamma-aminobutyric acid signaling pathway (GO:0007214)2.49428218
146inner cell mass cell proliferation (GO:0001833)2.48632939
147protein localization to synapse (GO:0035418)2.48362798
148oligodendrocyte differentiation (GO:0048709)2.47642649
149organ growth (GO:0035265)2.47044187
150heterochromatin organization (GO:0070828)2.46737416
151regulation of centriole replication (GO:0046599)2.46627008
152cell differentiation involved in kidney development (GO:0061005)2.46286534
153pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.46276486
154spliceosomal snRNP assembly (GO:0000387)2.45339200
155DNA replication initiation (GO:0006270)2.45303839
156forebrain neuron differentiation (GO:0021879)2.44211440
157regulation of establishment of cell polarity (GO:2000114)2.43805558
158DNA strand renaturation (GO:0000733)2.43694795
159regulation of synapse assembly (GO:0051963)2.41889884
160cranial nerve development (GO:0021545)2.41338915
161photoreceptor cell maintenance (GO:0045494)2.40785728
162forebrain neuron development (GO:0021884)2.40649796
163adult feeding behavior (GO:0008343)2.40409424
164import into cell (GO:0098657)2.40351636
165axonal fasciculation (GO:0007413)2.38990275
166regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.38539166
167mesenchymal cell differentiation (GO:0048762)2.38375571
168response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.36999096
169cerebral cortex cell migration (GO:0021795)2.36919420
170vocalization behavior (GO:0071625)2.36295369
171DNA integration (GO:0015074)2.35825714
172inner ear receptor stereocilium organization (GO:0060122)2.35245854
173regulation of collateral sprouting (GO:0048670)2.34549106
174photoreceptor cell differentiation (GO:0046530)2.33402273
175eye photoreceptor cell differentiation (GO:0001754)2.33402273
176mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.31054258
177myelination (GO:0042552)2.29158820
178negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.28330618
179facial nerve structural organization (GO:0021612)2.25900904
180female gonad development (GO:0008585)2.25847868
181neuron fate determination (GO:0048664)2.25231564
182cornea development in camera-type eye (GO:0061303)2.25038313
183spinal cord association neuron differentiation (GO:0021527)2.24386199
184amino acid import (GO:0043090)2.24319497
185ensheathment of neurons (GO:0007272)2.23597812
186axon ensheathment (GO:0008366)2.23597812
187cell differentiation in spinal cord (GO:0021515)2.23343501
188dopamine biosynthetic process (GO:0042416)2.23261527
189positive regulation of meiotic cell cycle (GO:0051446)2.22739357
190cardiac ventricle formation (GO:0003211)2.22180431
191neuron-neuron synaptic transmission (GO:0007270)2.21255073
192regulation of respiratory system process (GO:0044065)2.19894657
193serotonin receptor signaling pathway (GO:0007210)2.19014900
194regulation of respiratory gaseous exchange (GO:0043576)2.17925518
195positive regulation of meiosis (GO:0045836)2.15873241
196otic vesicle formation (GO:0030916)2.15442494
197synaptic transmission, glutamatergic (GO:0035249)2.15299106
198regulation of glutamate secretion (GO:0014048)2.13596146

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.50196108
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.50196108
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.50196108
4EZH2_22144423_ChIP-Seq_EOC_Human4.23337925
5E2F7_22180533_ChIP-Seq_HELA_Human3.71981517
6GBX2_23144817_ChIP-Seq_PC3_Human3.59903442
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.53390027
8FOXM1_23109430_ChIP-Seq_U2OS_Human3.43684211
9MYC_18555785_ChIP-Seq_MESCs_Mouse3.10819772
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.08291166
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.95534809
12* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.88021736
13* EZH2_27304074_Chip-Seq_ESCs_Mouse2.72530147
14* EED_16625203_ChIP-ChIP_MESCs_Mouse2.67404017
15* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.64922486
16* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.63037187
17CBX2_27304074_Chip-Seq_ESCs_Mouse2.54765524
18THAP11_20581084_ChIP-Seq_MESCs_Mouse2.54633903
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.53951532
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.53595523
21* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.46411503
22* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.46186745
23ETS1_20019798_ChIP-Seq_JURKAT_Human2.43454495
24* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.38397311
25XRN2_22483619_ChIP-Seq_HELA_Human2.35551153
26* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.34248250
27* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.33355282
28* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.33355282
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.30933561
30* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.30310751
31VDR_22108803_ChIP-Seq_LS180_Human2.25826129
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.24882481
33EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.24779891
34TP63_19390658_ChIP-ChIP_HaCaT_Human2.22919037
35TRIM28_21343339_ChIP-Seq_HEK293_Human2.18189594
36TAF15_26573619_Chip-Seq_HEK293_Human2.17800520
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.07699005
38* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.01652800
39* EZH2_27294783_Chip-Seq_ESCs_Mouse2.00054815
40KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.99703431
41DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.98656917
42MYC_19030024_ChIP-ChIP_MESCs_Mouse1.97994229
43* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.93136483
44RNF2_27304074_Chip-Seq_ESCs_Mouse1.92291478
45AR_21572438_ChIP-Seq_LNCaP_Human1.90924297
46* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.90466855
47GABP_19822575_ChIP-Seq_HepG2_Human1.87835071
48MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.83043800
49MYC_19079543_ChIP-ChIP_MESCs_Mouse1.82879451
50* RNF2_27304074_Chip-Seq_NSC_Mouse1.82247703
51ESR1_15608294_ChIP-ChIP_MCF-7_Human1.81000975
52P300_19829295_ChIP-Seq_ESCs_Human1.80436100
53TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80115578
54E2F4_17652178_ChIP-ChIP_JURKAT_Human1.79740742
55PCGF2_27294783_Chip-Seq_ESCs_Mouse1.79066597
56* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.78992112
57IGF1R_20145208_ChIP-Seq_DFB_Human1.78865146
58POU3F2_20337985_ChIP-ChIP_501MEL_Human1.78062494
59EST1_17652178_ChIP-ChIP_JURKAT_Human1.76462319
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.76340304
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.75738189
62CTBP2_25329375_ChIP-Seq_LNCAP_Human1.74860476
63GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.74642140
64KDM5A_27292631_Chip-Seq_BREAST_Human1.73015784
65CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.72389479
66CREB1_15753290_ChIP-ChIP_HEK293T_Human1.72276781
67* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.71122926
68BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.67485525
69FLI1_27457419_Chip-Seq_LIVER_Mouse1.67258057
70POU5F1_16153702_ChIP-ChIP_HESCs_Human1.67026341
71DCP1A_22483619_ChIP-Seq_HELA_Human1.66828537
72* TET1_21451524_ChIP-Seq_MESCs_Mouse1.66216238
73GABP_17652178_ChIP-ChIP_JURKAT_Human1.64588853
74E2F1_21310950_ChIP-Seq_MCF-7_Human1.64284260
75CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.63359389
76SMAD3_21741376_ChIP-Seq_EPCs_Human1.58280997
77CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.57433958
78SUZ12_27294783_Chip-Seq_NPCs_Mouse1.57167186
79ESR1_20079471_ChIP-ChIP_T-47D_Human1.55890050
80E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.55655415
81ZFX_18555785_ChIP-Seq_MESCs_Mouse1.54255318
82* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.53659030
83PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.53207201
84NANOG_18555785_Chip-Seq_ESCs_Mouse1.51744293
85FUS_26573619_Chip-Seq_HEK293_Human1.51600807
86E2F1_18555785_ChIP-Seq_MESCs_Mouse1.51100879
87NELFA_20434984_ChIP-Seq_ESCs_Mouse1.50603303
88PIAS1_25552417_ChIP-Seq_VCAP_Human1.50306179
89BP1_19119308_ChIP-ChIP_Hs578T_Human1.50042783
90SRF_21415370_ChIP-Seq_HL-1_Mouse1.49856222
91TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.49838806
92EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.48890143
93PCGF2_27294783_Chip-Seq_NPCs_Mouse1.47918358
94STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.47085063
95TTF2_22483619_ChIP-Seq_HELA_Human1.46929133
96RACK7_27058665_Chip-Seq_MCF-7_Human1.45541906
97ZNF263_19887448_ChIP-Seq_K562_Human1.45499905
98CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.44054015
99NFE2_27457419_Chip-Seq_LIVER_Mouse1.40814605
100ER_23166858_ChIP-Seq_MCF-7_Human1.39156354
101SMAD4_21799915_ChIP-Seq_A2780_Human1.38375785
102TP63_17297297_ChIP-ChIP_HaCaT_Human1.38282632
103E2F1_18555785_Chip-Seq_ESCs_Mouse1.38013439
104YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36919622
105FOXP1_21924763_ChIP-Seq_HESCs_Human1.36820497
106SUZ12_18555785_Chip-Seq_ESCs_Mouse1.36683468
107TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36617326
108NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.36409391
109OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34819113
110UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.34754817
111SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.34538717
112KLF4_18555785_ChIP-Seq_MESCs_Mouse1.34362877
113MYCN_18555785_ChIP-Seq_MESCs_Mouse1.34176516
114P53_22387025_ChIP-Seq_ESCs_Mouse1.34112648
115CMYC_18555785_Chip-Seq_ESCs_Mouse1.32290871
116EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.31009643
117TP53_18474530_ChIP-ChIP_U2OS_Human1.30837320
118VDR_21846776_ChIP-Seq_THP-1_Human1.30687770
119SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30180289
120SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29959362
121CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.29577237
122EZH2_27294783_Chip-Seq_NPCs_Mouse1.29248803
123STAT3_18555785_Chip-Seq_ESCs_Mouse1.28523381
124P300_18555785_Chip-Seq_ESCs_Mouse1.28003583
125CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26206316
126CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.25985194
127REST_21632747_ChIP-Seq_MESCs_Mouse1.25558276
128CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.24771097
129SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23692381
130TBX5_21415370_ChIP-Seq_HL-1_Mouse1.23421293
131TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23323546
132POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23323546
133PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22600268
134NMYC_18555785_Chip-Seq_ESCs_Mouse1.21398343
135VDR_23849224_ChIP-Seq_CD4+_Human1.19860643
136IKZF1_21737484_ChIP-ChIP_HCT116_Human1.19069060
137RUNX1_27457419_Chip-Seq_LIVER_Mouse1.18828059
138STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18471767
139SMAD_19615063_ChIP-ChIP_OVARY_Human1.17351451
140CTCF_26484167_Chip-Seq_Bcells_Mouse1.17160941
141SOX2_18555785_Chip-Seq_ESCs_Mouse1.16058286
142TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15902653
143* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.15734549
144CTCF_18555785_ChIP-Seq_MESCs_Mouse1.15267278
145SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.14986592
146TAL1_26923725_Chip-Seq_HPCs_Mouse1.14497839
147ELF1_17652178_ChIP-ChIP_JURKAT_Human1.14139943
148TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14007449
149PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.13558658
150* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.13511984
151CDX2_20551321_ChIP-Seq_CACO-2_Human1.12646617
152YY1_21170310_ChIP-Seq_MESCs_Mouse1.12617060
153OCT4_18555785_Chip-Seq_ESCs_Mouse1.11428330
154CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.10524448
155KLF4_18555785_Chip-Seq_ESCs_Mouse1.09897771
156* YY1_22570637_ChIP-Seq_MALME-3M_Human1.09705728
157MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.09658014
158EWS_26573619_Chip-Seq_HEK293_Human1.09271603
159MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08487166
160RUNX2_22187159_ChIP-Seq_PCA_Human1.07737421
161ELK3_25401928_ChIP-Seq_HUVEC_Human1.07378255
162PKCTHETA_26484144_Chip-Seq_BREAST_Human1.06780282
163P68_20966046_ChIP-Seq_HELA_Human1.06644266
164ZFX_18555785_Chip-Seq_ESCs_Mouse1.06308990
165KDM2B_26808549_Chip-Seq_REH_Human1.05963193
166* RING1B_27294783_Chip-Seq_NPCs_Mouse1.05822269
167RARG_19884340_ChIP-ChIP_MEFs_Mouse1.05685542
168DROSHA_22980978_ChIP-Seq_HELA_Human1.05567676
169PU1_27457419_Chip-Seq_LIVER_Mouse1.05553331
170ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05033660
171* RING1B_27294783_Chip-Seq_ESCs_Mouse1.04894171
172FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.04566179
173CTCF_21964334_Chip-Seq_Bcells_Human1.03777352
174ESRRB_18555785_Chip-Seq_ESCs_Mouse1.02929037
175SMAD1_18555785_Chip-Seq_ESCs_Mouse1.02495791
176AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02382617
177ARNT_22903824_ChIP-Seq_MCF-7_Human1.02035514
178AR_25329375_ChIP-Seq_VCAP_Human1.01977617
179* TP53_20018659_ChIP-ChIP_R1E_Mouse1.01777399
180ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.01710861
181* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.01710747
182NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01644564
183WT1_19549856_ChIP-ChIP_CCG9911_Human1.01109468
184SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.00865210
185* CHD1_26751641_Chip-Seq_LNCaP_Human0.98686114
186AR_21909140_ChIP-Seq_LNCAP_Human0.98324752
187POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.98318331
188CIITA_25753668_ChIP-Seq_RAJI_Human0.97517876
189FOXP3_21729870_ChIP-Seq_TREG_Human0.96660483
190NOTCH1_21737748_ChIP-Seq_TLL_Human0.96375822
191SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.95460506
192ERG_20887958_ChIP-Seq_HPC-7_Mouse0.94994060
193MYC_18940864_ChIP-ChIP_HL60_Human0.93280825
194CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93095887

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009780_abnormal_chondrocyte_physiolo5.05883143
2MP0003136_yellow_coat_color3.77664630
3MP0003880_abnormal_central_pattern3.48550481
4MP0002102_abnormal_ear_morphology3.46507027
5MP0001188_hyperpigmentation3.22509092
6MP0004233_abnormal_muscle_weight3.08463516
7MP0006292_abnormal_olfactory_placode3.06849451
8MP0000566_synostosis3.03741549
9MP0003693_abnormal_embryo_hatching2.91191088
10MP0000678_abnormal_parathyroid_gland2.79683966
11MP0010030_abnormal_orbit_morphology2.74356572
12MP0008057_abnormal_DNA_replication2.73903307
13MP0002160_abnormal_reproductive_system2.57739045
14MP0002234_abnormal_pharynx_morphology2.48101350
15MP0004381_abnormal_hair_follicle2.44932338
16MP0005409_darkened_coat_color2.43386741
17MP0004742_abnormal_vestibular_system2.41593761
18MP0005171_absent_coat_pigmentation2.39397445
19MP0002877_abnormal_melanocyte_morpholog2.37422019
20MP0001486_abnormal_startle_reflex2.32383953
21MP0010307_abnormal_tumor_latency2.24100871
22MP0003111_abnormal_nucleus_morphology2.19945859
23MP0010094_abnormal_chromosome_stability2.18715860
24MP0008007_abnormal_cellular_replicative2.15763493
25MP0003646_muscle_fatigue2.10530849
26MP0003938_abnormal_ear_development2.09479499
27MP0001881_abnormal_mammary_gland2.04053606
28MP0002277_abnormal_respiratory_mucosa1.98854466
29MP0003705_abnormal_hypodermis_morpholog1.98819686
30MP0000733_abnormal_muscle_development1.89843183
31MP0003077_abnormal_cell_cycle1.87171208
32MP0001968_abnormal_touch/_nociception1.86851729
33MP0005423_abnormal_somatic_nervous1.83053004
34MP0009745_abnormal_behavioral_response1.82490557
35MP0009379_abnormal_foot_pigmentation1.81209005
36MP0008058_abnormal_DNA_repair1.80021039
37MP0000778_abnormal_nervous_system1.79950469
38MP0008932_abnormal_embryonic_tissue1.76560667
39MP0004142_abnormal_muscle_tone1.75754624
40MP0006276_abnormal_autonomic_nervous1.75723089
41MP0003806_abnormal_nucleotide_metabolis1.74818110
42MP0009046_muscle_twitch1.72325567
43MP0000026_abnormal_inner_ear1.72233309
44MP0002272_abnormal_nervous_system1.72125469
45MP0002249_abnormal_larynx_morphology1.71788501
46MP0002735_abnormal_chemical_nociception1.71273221
47MP0002736_abnormal_nociception_after1.69086776
48MP0003786_premature_aging1.68891933
49MP0003941_abnormal_skin_development1.66438507
50MP0009250_abnormal_appendicular_skeleto1.65481349
51MP0000049_abnormal_middle_ear1.64955026
52MP0001905_abnormal_dopamine_level1.63765250
53MP0002572_abnormal_emotion/affect_behav1.61884384
54MP0001529_abnormal_vocalization1.58244522
55MP0002064_seizures1.57536918
56MP0008961_abnormal_basal_metabolism1.57387912
57MP0004185_abnormal_adipocyte_glucose1.57373290
58MP0005646_abnormal_pituitary_gland1.56066563
59MP0000759_abnormal_skeletal_muscle1.53373328
60MP0005645_abnormal_hypothalamus_physiol1.53290363
61MP0003635_abnormal_synaptic_transmissio1.51761550
62MP0000749_muscle_degeneration1.49645757
63MP0001440_abnormal_grooming_behavior1.49553367
64MP0000003_abnormal_adipose_tissue1.49505936
65MP0004957_abnormal_blastocyst_morpholog1.48538730
66* MP0002114_abnormal_axial_skeleton1.47563834
67MP0005670_abnormal_white_adipose1.46955677
68MP0005503_abnormal_tendon_morphology1.45918120
69MP0000920_abnormal_myelination1.45648430
70MP0004270_analgesia1.45585047
71MP0002108_abnormal_muscle_morphology1.44938463
72MP0004145_abnormal_muscle_electrophysio1.44627141
73MP0002067_abnormal_sensory_capabilities1.44006879
74MP0001963_abnormal_hearing_physiology1.43155743
75MP0005551_abnormal_eye_electrophysiolog1.41437760
76MP0001919_abnormal_reproductive_system1.40173280
77MP0001485_abnormal_pinna_reflex1.39770852
78MP0002638_abnormal_pupillary_reflex1.39189319
79MP0002734_abnormal_mechanical_nocicepti1.38377219
80MP0004859_abnormal_synaptic_plasticity1.36480956
81MP0006036_abnormal_mitochondrial_physio1.36409788
82MP0001346_abnormal_lacrimal_gland1.35448736
83MP0000631_abnormal_neuroendocrine_gland1.32193761
84MP0005389_reproductive_system_phenotype1.31645437
85MP0000762_abnormal_tongue_morphology1.31199895
86MP0000627_abnormal_mammary_gland1.30722479
87MP0000015_abnormal_ear_pigmentation1.30193338
88MP0002063_abnormal_learning/memory/cond1.29895251
89MP0002184_abnormal_innervation1.29654264
90MP0001661_extended_life_span1.27188301
91MP0005266_abnormal_metabolism1.27021556
92MP0001501_abnormal_sleep_pattern1.26836795
93MP0000750_abnormal_muscle_regeneration1.26433991
94MP0005379_endocrine/exocrine_gland_phen1.26343782
95MP0002557_abnormal_social/conspecific_i1.25654822
96MP0002752_abnormal_somatic_nervous1.25120632
97MP0005330_cardiomyopathy1.23719948
98MP0000013_abnormal_adipose_tissue1.23556249
99MP0001986_abnormal_taste_sensitivity1.22675695
100MP0002396_abnormal_hematopoietic_system1.21463874
101MP0008260_abnormal_autophagy1.21346780
102MP0002938_white_spotting1.20442689
103MP0001970_abnormal_pain_threshold1.19999913
104MP0003385_abnormal_body_wall1.18014840
105MP0001727_abnormal_embryo_implantation1.15964098
106MP0004130_abnormal_muscle_cell1.15514254
107MP0005408_hypopigmentation1.14130827
108MP0000350_abnormal_cell_proliferation1.13981760
109MP0002269_muscular_atrophy1.11726583
110MP0004134_abnormal_chest_morphology1.11660977
111MP0006072_abnormal_retinal_apoptosis1.08793472
112MP0002163_abnormal_gland_morphology1.05692784
113MP0002733_abnormal_thermal_nociception1.05492198
114MP0005253_abnormal_eye_physiology1.05417212
115MP0001984_abnormal_olfaction1.03025941
116MP0000681_abnormal_thyroid_gland1.02799207
117MP0000751_myopathy1.01240887
118MP0003942_abnormal_urinary_system1.00678273
119MP0003950_abnormal_plasma_membrane1.00221565
120MP0003937_abnormal_limbs/digits/tail_de0.99956533
121MP0002882_abnormal_neuron_morphology0.99071853
122MP0004087_abnormal_muscle_fiber0.98331848
123MP0001879_abnormal_lymphatic_vessel0.97845903
124MP0008789_abnormal_olfactory_epithelium0.97011409
125MP0005375_adipose_tissue_phenotype0.96602056
126MP0003283_abnormal_digestive_organ0.96224873
127MP0005451_abnormal_body_composition0.96119496
128MP0001502_abnormal_circadian_rhythm0.94709547
129MP0005174_abnormal_tail_pigmentation0.94018936
130MP0003755_abnormal_palate_morphology0.94016712
131MP0003936_abnormal_reproductive_system0.93774470
132MP0000747_muscle_weakness0.92753154
133MP0005380_embryogenesis_phenotype0.92471011
134MP0001672_abnormal_embryogenesis/_devel0.92471011
135MP0002751_abnormal_autonomic_nervous0.91600713
136MP0005647_abnormal_sex_gland0.91318883
137MP0001542_abnormal_bone_strength0.89474028
138MP0003984_embryonic_growth_retardation0.88736920
139MP0005257_abnormal_intraocular_pressure0.88593315
140MP0001873_stomach_inflammation0.88438566
141MP0001697_abnormal_embryo_size0.88303636
142MP0002177_abnormal_outer_ear0.87429724
143MP0005501_abnormal_skin_physiology0.86584042
144MP0004197_abnormal_fetal_growth/weight/0.85943307
145MP0002233_abnormal_nose_morphology0.85883800
146MP0002876_abnormal_thyroid_physiology0.85845261
147MP0002088_abnormal_embryonic_growth/wei0.85615562
148MP0004036_abnormal_muscle_relaxation0.84699942
149MP0005369_muscle_phenotype0.84026227
150MP0005195_abnormal_posterior_eye0.83896014
151MP0003011_delayed_dark_adaptation0.83604694
152MP0000383_abnormal_hair_follicle0.83024205
153MP0003315_abnormal_perineum_morphology0.81878579
154MP0001730_embryonic_growth_arrest0.81801372
155MP0009115_abnormal_fat_cell0.81692580
156MP0000372_irregular_coat_pigmentation0.81496484
157MP0003787_abnormal_imprinting0.81038518
158MP0003959_abnormal_lean_body0.80578267
159MP0000955_abnormal_spinal_cord0.80482429
160MP0008995_early_reproductive_senescence0.80383290
161MP0002932_abnormal_joint_morphology0.79248080
162MP0010386_abnormal_urinary_bladder0.78980976
163MP0004885_abnormal_endolymph0.77395605
164MP0000647_abnormal_sebaceous_gland0.75410003
165MP0002066_abnormal_motor_capabilities/c0.75327936
166MP0005394_taste/olfaction_phenotype0.74961210
167MP0005499_abnormal_olfactory_system0.74961210
168MP0003890_abnormal_embryonic-extraembry0.74957622
169MP0000462_abnormal_digestive_system0.74804050
170MP0002970_abnormal_white_adipose0.74791984
171MP0002085_abnormal_embryonic_tissue0.74388842
172MP0005076_abnormal_cell_differentiation0.73975557
173MP0000579_abnormal_nail_morphology0.73704686
174MP0002116_abnormal_craniofacial_bone0.73548948
175MP0000534_abnormal_ureter_morphology0.73297265
176MP0002697_abnormal_eye_size0.73183054
177MP0001340_abnormal_eyelid_morphology0.73047035
178MP0004043_abnormal_pH_regulation0.72562626
179MP0002109_abnormal_limb_morphology0.72137368
180MP0000467_abnormal_esophagus_morphology0.72125114
181MP0002332_abnormal_exercise_endurance0.70635311
182MP0005623_abnormal_meninges_morphology0.69359866
183MP0001664_abnormal_digestion0.68040337

Predicted human phenotypes

RankGene SetZ-score
1Parakeratosis (HP:0001036)4.25167634
2Double outlet right ventricle (HP:0001719)4.19565676
3Congenital malformation of the right heart (HP:0011723)4.19565676
4Septo-optic dysplasia (HP:0100842)3.78030074
5Microretrognathia (HP:0000308)3.74838518
6Nemaline bodies (HP:0003798)3.52273021
7Muscle fiber inclusion bodies (HP:0100299)3.46760565
8Absent/shortened dynein arms (HP:0200106)3.45660698
9Dynein arm defect of respiratory motile cilia (HP:0012255)3.45660698
10Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.39217270
11Focal motor seizures (HP:0011153)3.34349801
12Periauricular skin pits (HP:0100277)3.26507103
13Preauricular pit (HP:0004467)3.26507103
14Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.26061876
15Abnormal ciliary motility (HP:0012262)3.21581822
16Aplasia/Hypoplasia of the patella (HP:0006498)3.18173453
17Patellar aplasia (HP:0006443)3.12317038
18Hypoplastic left heart (HP:0004383)3.05698676
19Rectal prolapse (HP:0002035)3.04487940
20Aplasia cutis congenita (HP:0001057)2.98734399
21Absent septum pellucidum (HP:0001331)2.92624917
22Type 1 muscle fiber predominance (HP:0003803)2.92574727
23Acute lymphatic leukemia (HP:0006721)2.91455716
24Redundant skin (HP:0001582)2.89526111
25Chromosomal breakage induced by crosslinking agents (HP:0003221)2.88392348
26Duplicated collecting system (HP:0000081)2.88147207
27Nasolacrimal duct obstruction (HP:0000579)2.84051321
28Abnormality of secondary sexual hair (HP:0009888)2.82076050
29Abnormality of the axillary hair (HP:0100134)2.82076050
30Conical tooth (HP:0000698)2.79302558
31White forelock (HP:0002211)2.79200353
32Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.78030553
33Birth length less than 3rd percentile (HP:0003561)2.75499178
34Abnormality of the preputium (HP:0100587)2.74087640
35Progressive muscle weakness (HP:0003323)2.73222824
36Duplication of thumb phalanx (HP:0009942)2.73021645
37Aplasia/Hypoplasia of the uvula (HP:0010293)2.72705696
38Calcaneovalgus deformity (HP:0001848)2.71203146
39Febrile seizures (HP:0002373)2.69761872
40Abnormality of chromosome stability (HP:0003220)2.68893527
41Septate vagina (HP:0001153)2.68742481
42Abnormality of the septum pellucidum (HP:0007375)2.67649749
43Abnormality of the renal collecting system (HP:0004742)2.67368976
44Abnormal respiratory motile cilium morphology (HP:0005938)2.66232708
45Abnormal respiratory epithelium morphology (HP:0012253)2.66232708
46Patchy hypopigmentation of hair (HP:0011365)2.63685400
47Abnormal respiratory motile cilium physiology (HP:0012261)2.62066919
48Truncus arteriosus (HP:0001660)2.60397743
49Meckel diverticulum (HP:0002245)2.55637843
50Abnormality of the lacrimal duct (HP:0011481)2.55173544
51Lip pit (HP:0100267)2.54996893
52Myopathic facies (HP:0002058)2.54233914
53Reduced subcutaneous adipose tissue (HP:0003758)2.52798415
54Protruding tongue (HP:0010808)2.50576138
55Decreased central vision (HP:0007663)2.50076035
56Optic nerve hypoplasia (HP:0000609)2.49620490
57Abnormality of incisor morphology (HP:0011063)2.48137915
58Hyperalaninemia (HP:0003348)2.46412446
59Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.46412446
60Abnormality of alanine metabolism (HP:0010916)2.46412446
61Aplasia/Hypoplasia of the sacrum (HP:0008517)2.45980880
62Morphological abnormality of the middle ear (HP:0008609)2.45436645
63Abnormality of the ileum (HP:0001549)2.44537428
64Aplasia involving bones of the upper limbs (HP:0009823)2.43069554
65Aplasia of the phalanges of the hand (HP:0009802)2.43069554
66Aplasia involving bones of the extremities (HP:0009825)2.43069554
67Cupped ear (HP:0000378)2.42457507
68Abnormality of the nasolacrimal system (HP:0000614)2.41045118
69Abnormality of the aortic arch (HP:0012303)2.40004597
70Sclerocornea (HP:0000647)2.38976600
71Sparse lateral eyebrow (HP:0005338)2.38376232
72Short thumb (HP:0009778)2.37386404
73Skin pits (HP:0100276)2.33726747
74Congenital sensorineural hearing impairment (HP:0008527)2.32814540
75Abnormality of the carotid arteries (HP:0005344)2.32635312
76Concave nail (HP:0001598)2.32527376
77Abnormal mitochondria in muscle tissue (HP:0008316)2.32492068
78Chin dimple (HP:0010751)2.31996319
79Chromsome breakage (HP:0040012)2.31994247
80Upper limb muscle weakness (HP:0003484)2.31350537
81Deformed tarsal bones (HP:0008119)2.31217046
82Mixed hearing impairment (HP:0000410)2.31127886
83Partial duplication of thumb phalanx (HP:0009944)2.30765910
84Anomalous pulmonary venous return (HP:0010772)2.29658125
85Transposition of the great arteries (HP:0001669)2.28711522
86Abnormal connection of the cardiac segments (HP:0011545)2.28711522
87Abnormal ventriculo-arterial connection (HP:0011563)2.28711522
88Alacrima (HP:0000522)2.25126347
89Unilateral renal agenesis (HP:0000122)2.22462325
90Decreased subcutaneous fat (HP:0001002)2.16356366
91Underdeveloped nasal alae (HP:0000430)2.15016703
92Abnormal number of incisors (HP:0011064)2.13215045
93Abnormality of the pulmonary veins (HP:0011718)2.13052720
94Breast hypoplasia (HP:0003187)2.11771044
95Overfolded helix (HP:0000396)2.10716569
96Medial flaring of the eyebrow (HP:0010747)2.08996827
97Hyperventilation (HP:0002883)2.08548358
98Sex reversal (HP:0012245)2.08291166
99Abnormal sex determination (HP:0012244)2.08291166
100Aplasia/Hypoplasia of the tibia (HP:0005772)2.07792988
101Decreased lacrimation (HP:0000633)2.07776844
102Subaortic stenosis (HP:0001682)2.07585852
103Abnormality of the left ventricular outflow tract (HP:0011103)2.07585852
104Hypophosphatemic rickets (HP:0004912)2.06787559
105Down-sloping shoulders (HP:0200021)2.06597330
106Osteomalacia (HP:0002749)2.06420627
107Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.06358066
108Degeneration of the lateral corticospinal tracts (HP:0002314)2.06358066
109Acute necrotizing encephalopathy (HP:0006965)2.06321031
110Hyperthyroidism (HP:0000836)2.03051149
111Absent phalangeal crease (HP:0006109)2.02935960
112Pancreatic cysts (HP:0001737)2.02825990
113Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.02399307
114Increased corneal curvature (HP:0100692)2.01617435
115Keratoconus (HP:0000563)2.01617435
116Testicular atrophy (HP:0000029)2.01117545
117Partial duplication of the phalanx of hand (HP:0009999)2.00704218
118Absent radius (HP:0003974)2.00670207
119Congenital ichthyosiform erythroderma (HP:0007431)1.99919007
120Pancreatic fibrosis (HP:0100732)1.96134227
121Epileptic encephalopathy (HP:0200134)1.95913714
122Split foot (HP:0001839)1.94598548
123Recurrent corneal erosions (HP:0000495)1.94392507
124Abnormality of the nasal septum (HP:0000419)1.93061562
125Bulbar palsy (HP:0001283)1.92462885
126Exercise-induced myalgia (HP:0003738)1.92330855
127Vaginal atresia (HP:0000148)1.91192734
128Bifid uvula (HP:0000193)1.90958734
129Renal Fanconi syndrome (HP:0001994)1.90477663
130Genital tract atresia (HP:0001827)1.90169603
131Renal agenesis (HP:0000104)1.89796255
132Congenital stationary night blindness (HP:0007642)1.89277457
133Triphalangeal thumb (HP:0001199)1.88439225
134Selective tooth agenesis (HP:0001592)1.87989533
135Ulnar bowing (HP:0003031)1.87309456
136Gait imbalance (HP:0002141)1.85766798
137Synostosis involving the elbow (HP:0003938)1.84745372
138Humeroradial synostosis (HP:0003041)1.84745372
139Hypothermia (HP:0002045)1.84255741
140Hypoparathyroidism (HP:0000829)1.83958979
141Retinal dysplasia (HP:0007973)1.83937108
142Abnormality of subcutaneous fat tissue (HP:0001001)1.82756056
143Aplasia of the musculature (HP:0100854)1.82752939
144Absent forearm bone (HP:0003953)1.82384242
145Aplasia involving forearm bones (HP:0009822)1.82384242
146Broad-based gait (HP:0002136)1.82353533
147Abnormality of the fetal cardiovascular system (HP:0010948)1.82275783
148Abnormal umbilical cord blood vessels (HP:0011403)1.82275783
149Single umbilical artery (HP:0001195)1.82275783
150Abnormality of the parietal bone (HP:0002696)1.81519928
151Sensory axonal neuropathy (HP:0003390)1.81464083
152Attenuation of retinal blood vessels (HP:0007843)1.81117898
1533-Methylglutaconic aciduria (HP:0003535)1.81043174
154Absent speech (HP:0001344)1.80693988
155Prostate neoplasm (HP:0100787)1.80418647
156Optic disc pallor (HP:0000543)1.78835634
157Aplasia/Hypoplasia of the lens (HP:0008063)1.78079889
158Xerostomia (HP:0000217)1.77741873
159Nephronophthisis (HP:0000090)1.77568964
160Popliteal pterygium (HP:0009756)1.77115569
161Submucous cleft hard palate (HP:0000176)1.76279324
162Increased CSF lactate (HP:0002490)1.76204269
163Esotropia (HP:0000565)1.75610847
164Atonic seizures (HP:0010819)1.75039434
165Abnormality of molar (HP:0011077)1.74789161
166Abnormality of molar morphology (HP:0011070)1.74789161
167Nephrogenic diabetes insipidus (HP:0009806)1.74552213
168Abnormality of the umbilical cord (HP:0010881)1.74342374
169Infantile muscular hypotonia (HP:0008947)1.74311679
170Hypoplastic heart (HP:0001961)1.74284760
171Myelomeningocele (HP:0002475)1.74151399
172Limb dystonia (HP:0002451)1.73525002
173Exercise intolerance (HP:0003546)1.73475745
174Tubulointerstitial nephritis (HP:0001970)1.73471160
175Increased muscle lipid content (HP:0009058)1.73470741
176Hypoplasia of the iris (HP:0007676)1.73298295
177Thickened helices (HP:0000391)1.72631837
178Severe muscular hypotonia (HP:0006829)1.72248040
179Short clavicles (HP:0000894)1.72106852
180Acute encephalopathy (HP:0006846)1.71974340
181Abnormality of DNA repair (HP:0003254)1.71850606
182Hypoplastic pelvis (HP:0008839)1.71719482
183Abnormality of the phalanges of the hallux (HP:0010057)1.70501048
184Hypoplasia of the radius (HP:0002984)1.68668143
185Posterior embryotoxon (HP:0000627)1.67344846
186Preaxial hand polydactyly (HP:0001177)1.66427184
187Mitochondrial inheritance (HP:0001427)1.66392712
188Increased intramyocellular lipid droplets (HP:0012240)1.65383906
189Ulnar deviation of the wrist (HP:0003049)1.64907403
190Aplasia/Hypoplasia of the earlobes (HP:0009906)1.63541153
191Small intestinal stenosis (HP:0012848)1.62496242
192Duodenal stenosis (HP:0100867)1.62496242
193Nephroblastoma (Wilms tumor) (HP:0002667)1.62057428
194Lactic acidosis (HP:0003128)1.60866350

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.49877603
2BUB14.42134310
3VRK24.35389063
4SMG14.30637290
5TRIB33.11375461
6BLK3.09814225
7TAF13.08966981
8TNIK2.85465547
9NME22.59445949
10EEF2K2.26360065
11MKNK22.19817677
12PRPF4B2.15239323
13PKN12.09971154
14STK391.97691481
15ADRBK21.94844002
16CDK71.90391190
17INSRR1.90379358
18CDC71.87735841
19PBK1.85164053
20CHEK21.81010706
21MUSK1.79392807
22PLK41.76493784
23BMPR1B1.74412148
24EPHA41.73632343
25MAPK131.73075709
26OXSR11.70491075
27MAP2K71.69400793
28NTRK31.68137298
29GRK71.67290477
30BMPR21.64675555
31STK161.61227183
32GRK11.58032192
33PRKD31.51917376
34YES11.48420252
35TLK11.47434348
36TTK1.46987211
37AURKA1.46205226
38MKNK11.40649197
39BCKDK1.40082712
40FGR1.39142205
41CDK191.33337570
42RIPK41.31726967
43NEK61.30370830
44CDK31.26426239
45ICK1.24962172
46AKT21.24112098
47EIF2AK21.23933404
48BCR1.22886382
49MELK1.22194321
50MAPKAPK51.18454598
51MAPK111.16711881
52IRAK21.15398055
53NEK21.14771472
54MARK11.09775457
55ABL21.09660533
56MAP3K141.09439237
57DMPK1.08763857
58CLK11.07862760
59MAPK151.05631107
60EPHB21.05485283
61PLK11.05376726
62CDK121.04603633
63CHEK11.03741531
64PRKCE1.03210948
65ILK1.02434883
66RPS6KB21.01247056
67PDK21.01202207
68CAMK1G0.99103012
69PNCK0.98632023
70MAPKAPK30.97923828
71BRSK10.96384401
72FRK0.95064500
73ATR0.94920708
74SIK20.93847195
75TTN0.91909440
76PLK20.91833907
77GRK50.91758981
78CHUK0.91486237
79NTRK20.90980417
80IRAK10.89981845
81LIMK10.89632002
82CAMK2B0.88593922
83CAMK2A0.88511079
84CAMK1D0.88448939
85IRAK40.87212064
86NME10.86841359
87DYRK20.86615253
88TXK0.86246598
89FES0.86110724
90RPS6KA60.85920509
91MAPK70.84882866
92MST40.83549669
93NEK10.82032120
94AURKB0.81046572
95PRKCI0.79706852
96TNK20.78249468
97AKT30.77607229
98EIF2AK10.76943017
99IRAK30.75416018
100RPS6KA20.75280435
101SIK30.74227532
102ADRBK10.74077451
103NUAK10.73311620
104UHMK10.72905104
105CDK40.72210152
106MAP3K120.70895073
107CDK90.70221890
108WNK10.69771823
109CSNK1G30.69183682
110MAP3K130.67468903
111DYRK1A0.66996707
112ROCK20.66155334
113MTOR0.65681020
114DAPK10.65617077
115CDK11A0.65079930
116WNK40.64412083
117CDK80.64288122
118MAPK40.62325127
119PRKD20.61180316
120MAP2K30.59062583
121SRPK10.58344583
122MAPK120.57968298
123CDK150.55472014
124WEE10.55303629
125CAMK2D0.54767806
126CDK10.54577970
127IKBKE0.54392931
128OBSCN0.54003076
129MST1R0.53185556
130PRKCG0.52915519
131PRKG10.51973987
132RPS6KC10.51954705
133RPS6KL10.51954705
134PRKCQ0.51124995
135SGK4940.49243891
136SGK2230.49243891
137MAP3K40.48958323
138CDK180.48681274
139CCNB10.48548732
140ZAK0.47851408
141PRKACA0.47107876
142WNK30.46948990
143PAK10.46625519
144CDK20.45903568
145CSNK1E0.45330530
146CSNK2A10.45271037
147MARK20.44967335
148CSNK1A1L0.44767636
149RPS6KA50.44758201
150PDPK10.44656782
151SGK10.44393975
152IKBKB0.44020563
153VRK10.43484826
154CDK50.43143121
155ATM0.42758393
156PIK3CA0.41304348
157PIM20.40666680
158BRSK20.39732627
159CAMK2G0.39353275
160CSNK1G10.39041204
161RPS6KB10.39007898
162TRPM70.38579215
163DAPK30.38475815
164PINK10.38237429
165PHKG20.38175176
166PHKG10.38175176
167CSNK2A20.36499699
168CAMK10.35126305
169NEK90.34811800
170PIK3CG0.34563484
171MAPK140.33811099
172MAPKAPK20.33453662
173DAPK20.33332280
174LYN0.33294391
175NLK0.33091235
176ERBB40.32779343

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041225.27370542
2DNA replication_Homo sapiens_hsa030303.03820187
3Nicotine addiction_Homo sapiens_hsa050333.00717064
4RNA polymerase_Homo sapiens_hsa030202.69574730
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.62605504
6Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.59555278
7Phototransduction_Homo sapiens_hsa047442.49412796
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.46468438
9Oxidative phosphorylation_Homo sapiens_hsa001902.45599935
10Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.41118767
11Base excision repair_Homo sapiens_hsa034102.37342237
12Pyrimidine metabolism_Homo sapiens_hsa002402.27964111
13One carbon pool by folate_Homo sapiens_hsa006702.27073432
14Nucleotide excision repair_Homo sapiens_hsa034202.23447867
15Mismatch repair_Homo sapiens_hsa034302.18578995
16Serotonergic synapse_Homo sapiens_hsa047262.07192232
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.94562262
18Axon guidance_Homo sapiens_hsa043601.85681668
19Glutamatergic synapse_Homo sapiens_hsa047241.82512982
20Taste transduction_Homo sapiens_hsa047421.81650248
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.81548023
22Sulfur metabolism_Homo sapiens_hsa009201.80719910
23RNA transport_Homo sapiens_hsa030131.80165146
24Ether lipid metabolism_Homo sapiens_hsa005651.78536260
25Morphine addiction_Homo sapiens_hsa050321.76052747
26Sphingolipid metabolism_Homo sapiens_hsa006001.68592990
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.67220346
28Spliceosome_Homo sapiens_hsa030401.64932577
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.63052827
30Alzheimers disease_Homo sapiens_hsa050101.60155031
31Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.57224224
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.56975684
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.55888545
34Graft-versus-host disease_Homo sapiens_hsa053321.52072798
35Parkinsons disease_Homo sapiens_hsa050121.51590613
36Autoimmune thyroid disease_Homo sapiens_hsa053201.50626997
37Bladder cancer_Homo sapiens_hsa052191.46586059
38Cell cycle_Homo sapiens_hsa041101.45791722
39Collecting duct acid secretion_Homo sapiens_hsa049661.41362518
40GABAergic synapse_Homo sapiens_hsa047271.41338665
41Fructose and mannose metabolism_Homo sapiens_hsa000511.40251204
42Arachidonic acid metabolism_Homo sapiens_hsa005901.39932564
43Rheumatoid arthritis_Homo sapiens_hsa053231.39798614
44Non-homologous end-joining_Homo sapiens_hsa034501.39357689
45Cyanoamino acid metabolism_Homo sapiens_hsa004601.33746393
46Pyruvate metabolism_Homo sapiens_hsa006201.28683501
47Long-term depression_Homo sapiens_hsa047301.28554827
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.27709487
49Purine metabolism_Homo sapiens_hsa002301.25464009
50Fatty acid elongation_Homo sapiens_hsa000621.24715375
51Lysine degradation_Homo sapiens_hsa003101.24385633
52Selenocompound metabolism_Homo sapiens_hsa004501.21719809
53Folate biosynthesis_Homo sapiens_hsa007901.20686180
54Huntingtons disease_Homo sapiens_hsa050161.20371949
55Steroid biosynthesis_Homo sapiens_hsa001001.18540056
56Allograft rejection_Homo sapiens_hsa053301.17160856
57Calcium signaling pathway_Homo sapiens_hsa040201.16721575
58p53 signaling pathway_Homo sapiens_hsa041151.15821266
59Cardiac muscle contraction_Homo sapiens_hsa042601.15085204
60Circadian entrainment_Homo sapiens_hsa047131.14795932
61mRNA surveillance pathway_Homo sapiens_hsa030151.12241706
62African trypanosomiasis_Homo sapiens_hsa051431.11311732
63Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.08959764
64Fanconi anemia pathway_Homo sapiens_hsa034601.07122671
65Salivary secretion_Homo sapiens_hsa049701.06870966
66Asthma_Homo sapiens_hsa053101.03583416
67Linoleic acid metabolism_Homo sapiens_hsa005911.01611652
68Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.99134927
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.97791466
70Hedgehog signaling pathway_Homo sapiens_hsa043400.97709115
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.97472832
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.97160542
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.96594821
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.95369682
75Cocaine addiction_Homo sapiens_hsa050300.93071926
76Arginine and proline metabolism_Homo sapiens_hsa003300.92747122
77RNA degradation_Homo sapiens_hsa030180.92739715
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.92736681
79Olfactory transduction_Homo sapiens_hsa047400.91759747
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.90539588
81Renin secretion_Homo sapiens_hsa049240.89893733
82Basal cell carcinoma_Homo sapiens_hsa052170.89275474
83Vitamin B6 metabolism_Homo sapiens_hsa007500.88876804
84Wnt signaling pathway_Homo sapiens_hsa043100.87925442
85Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.87076392
862-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.85808662
87Ras signaling pathway_Homo sapiens_hsa040140.85527611
88Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.84723394
89Cholinergic synapse_Homo sapiens_hsa047250.83385555
90alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82310000
91Amphetamine addiction_Homo sapiens_hsa050310.80882082
92Oxytocin signaling pathway_Homo sapiens_hsa049210.80747921
93Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.80595798
94Proteasome_Homo sapiens_hsa030500.80291754
95Phagosome_Homo sapiens_hsa041450.80112942
96Dopaminergic synapse_Homo sapiens_hsa047280.79588809
97Pancreatic cancer_Homo sapiens_hsa052120.78882855
98Biosynthesis of amino acids_Homo sapiens_hsa012300.75376410
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74772769
100Ovarian steroidogenesis_Homo sapiens_hsa049130.74381687
101Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72875698
102Melanoma_Homo sapiens_hsa052180.71299377
103Malaria_Homo sapiens_hsa051440.70868954
104Synaptic vesicle cycle_Homo sapiens_hsa047210.70073601
105Protein export_Homo sapiens_hsa030600.68778281
106Melanogenesis_Homo sapiens_hsa049160.67804565
107Vascular smooth muscle contraction_Homo sapiens_hsa042700.67745878
108Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67220560
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65927112
110Thyroid cancer_Homo sapiens_hsa052160.65746735
111Mineral absorption_Homo sapiens_hsa049780.65159132
112Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65115796
113cAMP signaling pathway_Homo sapiens_hsa040240.64718732
114Basal transcription factors_Homo sapiens_hsa030220.63915508
115Nitrogen metabolism_Homo sapiens_hsa009100.62141776
116Ribosome_Homo sapiens_hsa030100.62037976
117Hematopoietic cell lineage_Homo sapiens_hsa046400.61379808
118MAPK signaling pathway_Homo sapiens_hsa040100.58943703
119Non-small cell lung cancer_Homo sapiens_hsa052230.58624308
120Metabolic pathways_Homo sapiens_hsa011000.58231413
121AMPK signaling pathway_Homo sapiens_hsa041520.57601708
122ErbB signaling pathway_Homo sapiens_hsa040120.54490998
123Gap junction_Homo sapiens_hsa045400.53771057
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53381661
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53237235
126Insulin secretion_Homo sapiens_hsa049110.52994501
127Carbon metabolism_Homo sapiens_hsa012000.52694894
128Vibrio cholerae infection_Homo sapiens_hsa051100.52271061
129Gastric acid secretion_Homo sapiens_hsa049710.51119126
130Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50848165
131Type I diabetes mellitus_Homo sapiens_hsa049400.50314523
132GnRH signaling pathway_Homo sapiens_hsa049120.48699713
133Intestinal immune network for IgA production_Homo sapiens_hsa046720.48681503
134Sphingolipid signaling pathway_Homo sapiens_hsa040710.48663897
135Histidine metabolism_Homo sapiens_hsa003400.48009597
136Homologous recombination_Homo sapiens_hsa034400.47952101
137Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.47393769
138NF-kappa B signaling pathway_Homo sapiens_hsa040640.46739623
139Other glycan degradation_Homo sapiens_hsa005110.46502639
140NOD-like receptor signaling pathway_Homo sapiens_hsa046210.45925905
141ECM-receptor interaction_Homo sapiens_hsa045120.45773285
142Choline metabolism in cancer_Homo sapiens_hsa052310.45664150
143Chronic myeloid leukemia_Homo sapiens_hsa052200.44155484
144Galactose metabolism_Homo sapiens_hsa000520.43518741
145Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42711206
146Small cell lung cancer_Homo sapiens_hsa052220.42489617
147Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42096637
148cGMP-PKG signaling pathway_Homo sapiens_hsa040220.42063053
149Chemokine signaling pathway_Homo sapiens_hsa040620.41803398
150Rap1 signaling pathway_Homo sapiens_hsa040150.41796705
151Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.41628510
152Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41294933
153Glioma_Homo sapiens_hsa052140.41268132
154Glutathione metabolism_Homo sapiens_hsa004800.40841416
155Dilated cardiomyopathy_Homo sapiens_hsa054140.40555722
156Insulin signaling pathway_Homo sapiens_hsa049100.39924718
157Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.39452203
158Proteoglycans in cancer_Homo sapiens_hsa052050.38186026
159Glycerolipid metabolism_Homo sapiens_hsa005610.36493506
160mTOR signaling pathway_Homo sapiens_hsa041500.36218169
161Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34603311
162Insulin resistance_Homo sapiens_hsa049310.34402014
163Oocyte meiosis_Homo sapiens_hsa041140.33786245
164Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33779650
165Fatty acid biosynthesis_Homo sapiens_hsa000610.33621197
166Pentose phosphate pathway_Homo sapiens_hsa000300.33396610
167Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.30802078
168MicroRNAs in cancer_Homo sapiens_hsa052060.30595075
169Hippo signaling pathway_Homo sapiens_hsa043900.29803427
170Adipocytokine signaling pathway_Homo sapiens_hsa049200.28621831
171Glucagon signaling pathway_Homo sapiens_hsa049220.26276682
172Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24079363
173Tyrosine metabolism_Homo sapiens_hsa003500.23606293
174Epstein-Barr virus infection_Homo sapiens_hsa051690.23140175
175Peroxisome_Homo sapiens_hsa041460.22990674
176Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.22729137
177Phenylalanine metabolism_Homo sapiens_hsa003600.20448198
178TGF-beta signaling pathway_Homo sapiens_hsa043500.19945658
179Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.19177147
180beta-Alanine metabolism_Homo sapiens_hsa004100.19175270

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