HOXC4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC4, is one of several homeobox HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Two alternatively spliced variants that encode the same protein have been described for HOXC4. Transcript variant one includes the shared exon, and transcript variant two includes only gene-specific exons. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1outer ear morphogenesis (GO:0042473)5.67580485
2lymph vessel development (GO:0001945)5.47161597
3regulation of mammary gland epithelial cell proliferation (GO:0033599)5.42183442
4phenol-containing compound catabolic process (GO:0019336)5.32211072
5facial nerve structural organization (GO:0021612)5.23948150
6sympathetic nervous system development (GO:0048485)5.16870275
7peripheral nervous system neuron development (GO:0048935)4.98559904
8diaphragm development (GO:0060539)4.79015272
9ribosomal small subunit biogenesis (GO:0042274)4.59971511
10behavioral response to nicotine (GO:0035095)4.51508774
11axon extension involved in axon guidance (GO:0048846)4.51163702
12neuron projection extension involved in neuron projection guidance (GO:1902284)4.51163702
13skeletal muscle organ development (GO:0060538)4.50609472
14muscle cell fate commitment (GO:0042693)4.30722795
15proximal/distal pattern formation (GO:0009954)4.16671528
16negative regulation of cell size (GO:0045792)4.16355920
17mesenchymal-epithelial cell signaling (GO:0060638)4.06802604
18heterochromatin organization (GO:0070828)3.89358967
19regulation of apoptotic process involved in morphogenesis (GO:1902337)3.83947523
20negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.83888426
21mammary gland epithelial cell differentiation (GO:0060644)3.83250109
22cranial nerve structural organization (GO:0021604)3.82842234
23embryonic skeletal system morphogenesis (GO:0048704)3.80428145
24embryonic skeletal system development (GO:0048706)3.80398301
25positive regulation of myotube differentiation (GO:0010831)3.76043247
26prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.71792124
27face development (GO:0060324)3.66088276
28DNA unwinding involved in DNA replication (GO:0006268)3.61681337
29regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.56026356
30N-terminal protein amino acid acetylation (GO:0006474)3.55271981
31tooth mineralization (GO:0034505)3.52886816
32cranial nerve morphogenesis (GO:0021602)3.51144499
33mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.40745096
34regulation of cardioblast proliferation (GO:0003264)3.40386018
35regulation of secondary heart field cardioblast proliferation (GO:0003266)3.40386018
36maturation of SSU-rRNA (GO:0030490)3.39516738
37regulation of chromatin binding (GO:0035561)3.34273789
38ganglion development (GO:0061548)3.33979632
39skeletal system morphogenesis (GO:0048705)3.30510806
40cartilage morphogenesis (GO:0060536)3.29410980
41spliceosomal tri-snRNP complex assembly (GO:0000244)3.28970863
42negative regulation of mRNA processing (GO:0050686)3.21443216
43vitamin A metabolic process (GO:0006776)3.20732144
44muscle organ morphogenesis (GO:0048644)3.20426550
45mitotic chromosome condensation (GO:0007076)3.17748293
46positive regulation of transcription regulatory region DNA binding (GO:2000679)3.17178424
47embryonic viscerocranium morphogenesis (GO:0048703)3.15977195
48motor neuron axon guidance (GO:0008045)3.15519318
49anterior/posterior pattern specification (GO:0009952)3.12162264
50definitive hemopoiesis (GO:0060216)3.10918024
51regulation of heart morphogenesis (GO:2000826)3.10288337
52regulation of translational fidelity (GO:0006450)3.09148480
53intracellular estrogen receptor signaling pathway (GO:0030520)3.08059296
54regulation of NFAT protein import into nucleus (GO:0051532)3.05734113
55neuron fate specification (GO:0048665)3.04098479
56proline biosynthetic process (GO:0006561)3.04080665
57paraxial mesoderm development (GO:0048339)3.03169660
58positive regulation of heat generation (GO:0031652)3.02742309
59eyelid development in camera-type eye (GO:0061029)2.99959382
60mitotic sister chromatid segregation (GO:0000070)2.98399333
61planar cell polarity pathway involved in neural tube closure (GO:0090179)2.98352504
62wound healing, spreading of epidermal cells (GO:0035313)2.97730580
63coronary vasculature morphogenesis (GO:0060977)2.97084145
64cell proliferation involved in metanephros development (GO:0072203)2.96880878
65kidney mesenchyme development (GO:0072074)2.96758570
66regulation of translational termination (GO:0006449)2.96478992
67positive regulation of chemokine biosynthetic process (GO:0045080)2.94170688
68head development (GO:0060322)2.92388578
69positive regulation of interleukin-1 beta secretion (GO:0050718)2.92268865
70respiratory tube development (GO:0030323)2.92054385
71embryonic forelimb morphogenesis (GO:0035115)2.91729912
72positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.90929920
73cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.90562212
74nuclear pore complex assembly (GO:0051292)2.90444358
75heart trabecula formation (GO:0060347)2.90391306
76negative regulation of chondrocyte differentiation (GO:0032331)2.90094089
77metanephric mesenchyme development (GO:0072075)2.89510570
78embryonic skeletal joint morphogenesis (GO:0060272)2.84213616
79mitotic sister chromatid cohesion (GO:0007064)2.84047604
80pre-miRNA processing (GO:0031054)2.83986639
81lateral sprouting from an epithelium (GO:0060601)2.83313913
82embryonic organ morphogenesis (GO:0048562)2.83263304
83mesenchymal to epithelial transition (GO:0060231)2.82867897
84regulation of organ formation (GO:0003156)2.82488878
85cochlea morphogenesis (GO:0090103)2.81712779
86cellular response to nicotine (GO:0071316)2.81116699
87viral mRNA export from host cell nucleus (GO:0046784)2.81004280
88lung-associated mesenchyme development (GO:0060484)2.80118152
89positive regulation of interleukin-1 beta production (GO:0032731)2.79036469
90negative regulation of mRNA metabolic process (GO:1903312)2.77187703
91forelimb morphogenesis (GO:0035136)2.76995545
92regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.76647794
93regulation of integrin activation (GO:0033623)2.76331912
94organ induction (GO:0001759)2.76121864
95formation of translation preinitiation complex (GO:0001731)2.75370024
96Golgi transport vesicle coating (GO:0048200)2.75039324
97COPI coating of Golgi vesicle (GO:0048205)2.75039324
98protein localization to microtubule (GO:0035372)2.74713927
99regulation of vitamin D biosynthetic process (GO:0060556)2.74392534
100mesenchymal cell differentiation (GO:0048762)2.74365478
101peptidyl-arginine omega-N-methylation (GO:0035247)2.73924157
102negative regulation of RNA splicing (GO:0033119)2.73591070
103histone H2B ubiquitination (GO:0033523)2.73495386
104DNA replication initiation (GO:0006270)2.73305554
105craniofacial suture morphogenesis (GO:0097094)2.72936536
106bone trabecula formation (GO:0060346)2.71966787
107sister chromatid segregation (GO:0000819)2.71617236
108ribonucleoprotein complex biogenesis (GO:0022613)2.70906757
109branching involved in prostate gland morphogenesis (GO:0060442)2.69859325
110embryonic digestive tract development (GO:0048566)2.69003759
111embryonic heart tube development (GO:0035050)2.68988195
112neural crest cell development (GO:0014032)2.68266592
113anatomical structure arrangement (GO:0048532)2.67060116
114mesenchymal cell proliferation (GO:0010463)2.66500135
115maternal placenta development (GO:0001893)2.66043801
116adherens junction assembly (GO:0034333)2.65660896
117embryonic cranial skeleton morphogenesis (GO:0048701)2.65182436
118metanephros development (GO:0001656)2.65100044
119peptidyl-lysine dimethylation (GO:0018027)2.64708914
120regulation of RNA export from nucleus (GO:0046831)2.64286274
121pharyngeal system development (GO:0060037)2.63652696
122nuclear envelope reassembly (GO:0031468)2.63265956
123mitotic nuclear envelope reassembly (GO:0007084)2.63265956
124chondrocyte proliferation (GO:0035988)2.63106653
125thyroid gland development (GO:0030878)2.61321810
126positive regulation of interleukin-1 secretion (GO:0050716)2.60384346
127positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.59620848
128protein complex localization (GO:0031503)2.59022804
129regulation of hair follicle development (GO:0051797)2.59012058
130mesonephros development (GO:0001823)2.58980433
131nuclear pore organization (GO:0006999)2.58853253
132DNA strand elongation (GO:0022616)2.58797209
133middle ear morphogenesis (GO:0042474)2.58582387
134positive regulation of DNA-dependent DNA replication (GO:2000105)2.57771602
135positive regulation of skeletal muscle tissue development (GO:0048643)2.57725673
136DNA strand elongation involved in DNA replication (GO:0006271)2.57496429
137outflow tract septum morphogenesis (GO:0003148)2.56382954
138regulation of fever generation (GO:0031620)2.56082621
139negative regulation of striated muscle cell differentiation (GO:0051154)2.55826471
140RNA stabilization (GO:0043489)2.54141938
141mRNA stabilization (GO:0048255)2.54141938
142DNA packaging (GO:0006323)2.53818145
143chromosome condensation (GO:0030261)2.53641806
144positive regulation of cellular amide metabolic process (GO:0034250)2.53189417
145folic acid metabolic process (GO:0046655)2.52421647
146notochord development (GO:0030903)2.52051419
147rRNA transcription (GO:0009303)2.51693704
148NIK/NF-kappaB signaling (GO:0038061)2.51627743
149negative regulation of fatty acid transport (GO:2000192)2.50477745
150embryonic camera-type eye development (GO:0031076)2.50280460
151viral transcription (GO:0019083)2.50132525
152negative regulation of cartilage development (GO:0061037)2.49602586
153epithelial cell maturation (GO:0002070)2.49541757
154enteric nervous system development (GO:0048484)2.49509089
155regulation of interleukin-1 beta secretion (GO:0050706)2.49092585
156body morphogenesis (GO:0010171)2.48843667
157embryonic limb morphogenesis (GO:0030326)2.48753968
158embryonic appendage morphogenesis (GO:0035113)2.48753968
159nucleosome disassembly (GO:0006337)2.48538289
160protein-DNA complex disassembly (GO:0032986)2.48538289
161cellular protein complex localization (GO:0034629)2.48514597
162positive regulation of developmental pigmentation (GO:0048087)2.48193835
163hindlimb morphogenesis (GO:0035137)2.48191838
164mitotic G1 DNA damage checkpoint (GO:0031571)2.48175003
165positive regulation of interleukin-1 production (GO:0032732)2.48115838
166mesenchymal cell differentiation involved in renal system development (GO:2001012)2.48023902
167mesenchymal cell differentiation involved in kidney development (GO:0072161)2.48023902
168cellular response to prostaglandin stimulus (GO:0071379)2.44665993
169polarized epithelial cell differentiation (GO:0030859)2.44193531
170norepinephrine metabolic process (GO:0042415)2.44180507
171regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.42265621
172mesodermal cell differentiation (GO:0048333)2.42164300
173regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.41834620
174appendage morphogenesis (GO:0035107)2.41740381
175limb morphogenesis (GO:0035108)2.41740381
176regulation of non-canonical Wnt signaling pathway (GO:2000050)2.38332864

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.12198631
2E2F7_22180533_ChIP-Seq_HELA_Human5.04215882
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.85854595
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.85854595
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.85854595
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.64739273
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.46279522
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.13644726
9TRIM28_21343339_ChIP-Seq_HEK293_Human3.12132798
10CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.96224168
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.86350608
12* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.86344280
13* TP63_19390658_ChIP-ChIP_HaCaT_Human2.82725457
14* EED_16625203_ChIP-ChIP_MESCs_Mouse2.78359933
15* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.72827801
16TP53_20018659_ChIP-ChIP_R1E_Mouse2.65253001
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.59623929
18MYC_22102868_ChIP-Seq_BL_Human2.59540994
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.56084474
20FOXM1_23109430_ChIP-Seq_U2OS_Human2.56008093
21XRN2_22483619_ChIP-Seq_HELA_Human2.50874588
22* CDX2_20551321_ChIP-Seq_CACO-2_Human2.41297272
23TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.38729748
24JARID2_20064375_ChIP-Seq_MESCs_Mouse2.35064210
25EGR1_19374776_ChIP-ChIP_THP-1_Human2.34864978
26JARID2_20075857_ChIP-Seq_MESCs_Mouse2.34383122
27* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.31655530
28* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.25303782
29* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.25303782
30* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.24364451
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.18609818
32IKZF1_21737484_ChIP-ChIP_HCT116_Human2.12397332
33VDR_21846776_ChIP-Seq_THP-1_Human2.09170668
34* CDX2_19796622_ChIP-Seq_MESCs_Mouse2.07412655
35FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.98392484
36TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.97516822
37DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.96274752
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.95202753
39WT1_19549856_ChIP-ChIP_CCG9911_Human1.94072439
40TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.93998690
41* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.93442509
42* CBX2_27304074_Chip-Seq_ESCs_Mouse1.93311141
43MYC_18358816_ChIP-ChIP_MESCs_Mouse1.92710379
44* RACK7_27058665_Chip-Seq_MCF-7_Human1.92398229
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.91239251
46LXR_22292898_ChIP-Seq_THP-1_Human1.90460563
47ESR1_15608294_ChIP-ChIP_MCF-7_Human1.88009319
48* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.86516499
49CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.82912894
50MYC_19079543_ChIP-ChIP_MESCs_Mouse1.82195570
51* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.79435276
52* TET1_21451524_ChIP-Seq_MESCs_Mouse1.78702504
53WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.75373912
54RARG_19884340_ChIP-ChIP_MEFs_Mouse1.75269660
55MYC_19030024_ChIP-ChIP_MESCs_Mouse1.74862788
56ZFX_18555785_ChIP-Seq_MESCs_Mouse1.73441438
57CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.73060773
58* RING1B_27294783_Chip-Seq_NPCs_Mouse1.72168332
59ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.71933083
60HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.71394811
61* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.70807283
62EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.67859907
63FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.64713181
64* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.63726641
65TTF2_22483619_ChIP-Seq_HELA_Human1.61277031
66NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.60436883
67CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.58315136
68KDM5A_27292631_Chip-Seq_BREAST_Human1.57674080
69ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.56879215
70RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.55933003
71SMAD_19615063_ChIP-ChIP_OVARY_Human1.54972805
72E2F1_21310950_ChIP-Seq_MCF-7_Human1.51285611
73JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.47067485
74CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.47056501
75AR_21909140_ChIP-Seq_LNCAP_Human1.45514704
76CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.42247757
77SALL1_21062744_ChIP-ChIP_HESCs_Human1.41839357
78SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.41599152
79SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.41597947
80CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.40389366
81DCP1A_22483619_ChIP-Seq_HELA_Human1.40012793
82* RNF2_27304074_Chip-Seq_ESCs_Mouse1.39590934
83POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.38555506
84ETS1_20019798_ChIP-Seq_JURKAT_Human1.36782814
85PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.36600665
86CIITA_25753668_ChIP-Seq_RAJI_Human1.35893316
87KDM2B_26808549_Chip-Seq_DND41_Human1.35572546
88* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.34809909
89* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.34809909
90EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34427287
91CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.30454926
92SRY_22984422_ChIP-ChIP_TESTIS_Rat1.29658626
93HIF1A_21447827_ChIP-Seq_MCF-7_Human1.29450479
94P300_27058665_Chip-Seq_ZR-75-30cells_Human1.29308733
95* SA1_27219007_Chip-Seq_ERYTHROID_Human1.29172316
96ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.28583585
97GABP_19822575_ChIP-Seq_HepG2_Human1.28507143
98ZFP281_18757296_ChIP-ChIP_E14_Mouse1.27535021
99* P68_20966046_ChIP-Seq_HELA_Human1.27142635
100RING1B_27294783_Chip-Seq_ESCs_Mouse1.26732770
101CTCF_27219007_Chip-Seq_ERYTHROID_Human1.26728273
102THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.26403443
103IRF8_21731497_ChIP-ChIP_J774_Mouse1.26375373
104ESR1_21235772_ChIP-Seq_MCF-7_Human1.25385228
105KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23919331
106* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.22564772
107MYCN_18555785_ChIP-Seq_MESCs_Mouse1.22164147
108SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.21811366
109* EZH2_27294783_Chip-Seq_ESCs_Mouse1.21394890
110VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.20655559
111NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.20571467
112* CHD1_26751641_Chip-Seq_LNCaP_Human1.20481785
113ZNF263_19887448_ChIP-Seq_K562_Human1.19982931
114KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.19728754
115TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19172789
116* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.18458018
117TCF7_22412390_ChIP-Seq_EML_Mouse1.18300608
118SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.18026086
119CREB1_26743006_Chip-Seq_LNCaP_Human1.17878141
120KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16396070
121* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.16312585
122ELK3_25401928_ChIP-Seq_HUVEC_Human1.15937264
123CREB1_15753290_ChIP-ChIP_HEK293T_Human1.15887283
124CJUN_26792858_Chip-Seq_BT549_Human1.14174570
125SOX9_24532713_ChIP-Seq_HFSC_Mouse1.13096343
126EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.12625560
127E2F4_17652178_ChIP-ChIP_JURKAT_Human1.11158319
128MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.10559704
129KDM2B_26808549_Chip-Seq_JURKAT_Human1.10300918
130* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10076371
131BRD4_25478319_ChIP-Seq_HGPS_Human1.09939715
132* UBF1/2_26484160_Chip-Seq_HMECs_Human1.09705461
133* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.09675192
134VDR_24787735_ChIP-Seq_THP-1_Human1.09127884
135* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.08929568
136NELFA_20434984_ChIP-Seq_ESCs_Mouse1.08914572
137* RNF2_27304074_Chip-Seq_NSC_Mouse1.08129240
138KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07595163
139CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.06978595
140CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.06371188
141BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.06369071
142ISL1_27105846_Chip-Seq_CPCs_Mouse1.06132556
143Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.05790032
144DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.04551527
145TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00527177
146KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.98416250
147STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.97773367
148STAT6_21828071_ChIP-Seq_BEAS2B_Human0.97685369
149STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.95695558
150DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94805552
151KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.94502354
152ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94341482
153* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94083618
154CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.92997249
155KDM2B_26808549_Chip-Seq_SUP-B15_Human0.92890864
156KDM2B_26808549_Chip-Seq_K562_Human0.92816430
157SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.92376078
158KLF5_25053715_ChIP-Seq_YYC3_Human0.92278810
159RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.91477612
160TP53_18474530_ChIP-ChIP_U2OS_Human0.89108936
161PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.88764669
162ERG_21242973_ChIP-ChIP_JURKAT_Human0.88113842
163STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.87913732
164AHR_22903824_ChIP-Seq_MCF-7_Human0.87490038
165FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.85812868
166IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.83033611
167JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81113957
168* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.79530682
169* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.79014804

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology3.02758862
2MP0002877_abnormal_melanocyte_morpholog2.87707165
3MP0002249_abnormal_larynx_morphology2.72757312
4MP0002822_catalepsy2.59288573
5MP0009250_abnormal_appendicular_skeleto2.47304337
6MP0003693_abnormal_embryo_hatching2.41112719
7MP0003942_abnormal_urinary_system2.39385235
8MP0003385_abnormal_body_wall2.32155449
9MP0000678_abnormal_parathyroid_gland2.30563256
10MP0003111_abnormal_nucleus_morphology2.27358023
11MP0002282_abnormal_trachea_morphology2.23551053
12MP0009278_abnormal_bone_marrow2.21435755
13MP0000516_abnormal_urinary_system2.20256766
14MP0005367_renal/urinary_system_phenotyp2.20256766
15MP0005623_abnormal_meninges_morphology2.18556211
16MP0004233_abnormal_muscle_weight2.13202022
17MP0000537_abnormal_urethra_morphology2.13044580
18MP0000049_abnormal_middle_ear2.03185414
19MP0003941_abnormal_skin_development2.01577770
20MP0000569_abnormal_digit_pigmentation1.98484128
21MP0002234_abnormal_pharynx_morphology1.95970333
22MP0003077_abnormal_cell_cycle1.94797687
23MP0000534_abnormal_ureter_morphology1.83237920
24MP0003122_maternal_imprinting1.82822659
25MP0002009_preneoplasia1.82257837
26MP0010094_abnormal_chromosome_stability1.81938868
27MP0002751_abnormal_autonomic_nervous1.81132954
28MP0004185_abnormal_adipocyte_glucose1.80881467
29MP0002932_abnormal_joint_morphology1.73841597
30MP0003705_abnormal_hypodermis_morpholog1.73815774
31MP0005503_abnormal_tendon_morphology1.73693162
32MP0002277_abnormal_respiratory_mucosa1.73469660
33MP0002938_white_spotting1.72994144
34MP0010386_abnormal_urinary_bladder1.68697841
35MP0002254_reproductive_system_inflammat1.68061975
36MP0003938_abnormal_ear_development1.64243789
37MP0000762_abnormal_tongue_morphology1.60547397
38MP0000733_abnormal_muscle_development1.58189108
39MP0000538_abnormal_urinary_bladder1.57424346
40MP0000003_abnormal_adipose_tissue1.55572064
41MP0000372_irregular_coat_pigmentation1.54201152
42MP0002638_abnormal_pupillary_reflex1.53338167
43MP0005076_abnormal_cell_differentiation1.53184040
44MP0003755_abnormal_palate_morphology1.52247316
45MP0001188_hyperpigmentation1.51874767
46MP0002102_abnormal_ear_morphology1.51840556
47MP0002160_abnormal_reproductive_system1.50836915
48MP0005187_abnormal_penis_morphology1.49715166
49MP0008438_abnormal_cutaneous_collagen1.48135363
50MP0000350_abnormal_cell_proliferation1.47648795
51MP0005508_abnormal_skeleton_morphology1.45550548
52MP0002108_abnormal_muscle_morphology1.44026530
53MP0002177_abnormal_outer_ear1.43905796
54MP0004957_abnormal_blastocyst_morpholog1.42356697
55MP0005257_abnormal_intraocular_pressure1.39054171
56MP0002116_abnormal_craniofacial_bone1.36368168
57MP0000383_abnormal_hair_follicle1.34852802
58MP0002332_abnormal_exercise_endurance1.34726696
59MP0003315_abnormal_perineum_morphology1.33571749
60MP0001346_abnormal_lacrimal_gland1.32959561
61* MP0002114_abnormal_axial_skeleton1.31916088
62MP0000428_abnormal_craniofacial_morphol1.31219669
63MP0003937_abnormal_limbs/digits/tail_de1.31084960
64MP0002109_abnormal_limb_morphology1.29970322
65MP0001340_abnormal_eyelid_morphology1.29205144
66MP0001730_embryonic_growth_arrest1.21370969
67MP0008260_abnormal_autophagy1.21257568
68MP0009053_abnormal_anal_canal1.20698789
69MP0003136_yellow_coat_color1.17385311
70MP0000751_myopathy1.16228686
71MP0004272_abnormal_basement_membrane1.15984293
72MP0008007_abnormal_cellular_replicative1.15851581
73MP0008057_abnormal_DNA_replication1.14673021
74MP0005248_abnormal_Harderian_gland1.14232750
75MP0010352_gastrointestinal_tract_polyps1.14057887
76MP0004782_abnormal_surfactant_physiolog1.14052584
77MP0003935_abnormal_craniofacial_develop1.11649556
78MP0009384_cardiac_valve_regurgitation1.10745291
79MP0001270_distended_abdomen1.10073301
80MP0005375_adipose_tissue_phenotype1.08285514
81MP0002085_abnormal_embryonic_tissue1.08198673
82MP0005275_abnormal_skin_tensile1.05840035
83MP0003115_abnormal_respiratory_system1.04912711
84MP0009672_abnormal_birth_weight1.03942798
85MP0000432_abnormal_head_morphology1.01538060
86MP0000759_abnormal_skeletal_muscle1.01228349
87MP0002184_abnormal_innervation1.00083269
88MP0002060_abnormal_skin_morphology0.99797636
89MP0000749_muscle_degeneration0.97676304
90MP0003786_premature_aging0.96981291
91MP0001672_abnormal_embryogenesis/_devel0.95124202
92MP0005380_embryogenesis_phenotype0.95124202
93MP0002269_muscular_atrophy0.95063856
94MP0001661_extended_life_span0.95053781
95MP0000579_abnormal_nail_morphology0.95033382
96MP0002132_abnormal_respiratory_system0.94420587
97MP0004858_abnormal_nervous_system0.94144607
98MP0005501_abnormal_skin_physiology0.94137941
99MP0002098_abnormal_vibrissa_morphology0.92812459
100MP0005666_abnormal_adipose_tissue0.92553335
101MP0003567_abnormal_fetal_cardiomyocyte0.92193892
102MP0005197_abnormal_uvea_morphology0.92099145
103MP0003011_delayed_dark_adaptation0.91934344
104MP0002163_abnormal_gland_morphology0.90748016
105MP0003566_abnormal_cell_adhesion0.90317073
106MP0001348_abnormal_lacrimal_gland0.89132402
107MP0000163_abnormal_cartilage_morphology0.88768210
108MP0001873_stomach_inflammation0.88582228
109MP0002115_abnormal_skeleton_extremities0.88525509
110MP0002697_abnormal_eye_size0.88521106
111MP0009780_abnormal_chondrocyte_physiolo0.88335304
112MP0000858_altered_metastatic_potential0.87676479
113MP0000750_abnormal_muscle_regeneration0.86552156
114MP0004087_abnormal_muscle_fiber0.86484051
115MP0005171_absent_coat_pigmentation0.86365758
116MP0000955_abnormal_spinal_cord0.85519897
117MP0003984_embryonic_growth_retardation0.85290553
118MP0002080_prenatal_lethality0.85146713
119* MP0000767_abnormal_smooth_muscle0.84614589
120MP0008932_abnormal_embryonic_tissue0.83764166
121MP0004197_abnormal_fetal_growth/weight/0.83721558
122MP0003121_genomic_imprinting0.83186472
123MP0003091_abnormal_cell_migration0.82473765
124MP0005409_darkened_coat_color0.82221776
125MP0000313_abnormal_cell_death0.81678866
126MP0001299_abnormal_eye_distance/0.81469620
127MP0005670_abnormal_white_adipose0.80620862
128MP0000681_abnormal_thyroid_gland0.80049688
129MP0004134_abnormal_chest_morphology0.79645253
130MP0001697_abnormal_embryo_size0.79541518
131MP0003448_altered_tumor_morphology0.79453392
132MP0001243_abnormal_dermal_layer0.79441973
133MP0002088_abnormal_embryonic_growth/wei0.79253761
134MP0002092_abnormal_eye_morphology0.78193107
135MP0005451_abnormal_body_composition0.77975380
136MP0003123_paternal_imprinting0.77910005
137MP0001293_anophthalmia0.76480200
138MP0002081_perinatal_lethality0.75941320
139MP0002111_abnormal_tail_morphology0.75794090
140MP0000566_synostosis0.75739538
141MP0003279_aneurysm0.75378929
142MP0001879_abnormal_lymphatic_vessel0.74751226
143MP0001919_abnormal_reproductive_system0.74584470
144MP0010630_abnormal_cardiac_muscle0.74268643
145MP0010307_abnormal_tumor_latency0.73079343
146MP0000747_muscle_weakness0.72903125
147MP0001545_abnormal_hematopoietic_system0.72633033
148MP0005397_hematopoietic_system_phenotyp0.72633033
149MP0001881_abnormal_mammary_gland0.72605609
150MP0002233_abnormal_nose_morphology0.72381115
151* MP0002113_abnormal_skeleton_development0.71574616
152MP0004381_abnormal_hair_follicle0.71363508
153MP0000627_abnormal_mammary_gland0.71217473
154MP0002084_abnormal_developmental_patter0.70608027
155MP0003861_abnormal_nervous_system0.67955531

Predicted human phenotypes

RankGene SetZ-score
1Rectal fistula (HP:0100590)4.71126972
2Rectovaginal fistula (HP:0000143)4.71126972
3Hypothermia (HP:0002045)4.41243554
4Intestinal fistula (HP:0100819)4.34139390
5Septate vagina (HP:0001153)4.14541935
6Abnormality of the phalanges of the hallux (HP:0010057)3.96838386
7Vaginal fistula (HP:0004320)3.86628902
8Aplasia/Hypoplasia of the sacrum (HP:0008517)3.84041170
9Recurrent bacterial skin infections (HP:0005406)3.58518816
10Orthostatic hypotension (HP:0001278)3.48368447
11Recurrent abscess formation (HP:0002722)3.32114071
12Neonatal hypoglycemia (HP:0001998)3.27946426
13Hyperacusis (HP:0010780)3.20071258
14Bicornuate uterus (HP:0000813)3.19338339
15Abnormality of the parietal bone (HP:0002696)3.17750651
16Midline defect of the nose (HP:0004122)3.16682174
17Double outlet right ventricle (HP:0001719)3.13970419
18Congenital malformation of the right heart (HP:0011723)3.13970419
19Unilateral renal agenesis (HP:0000122)3.01512004
20Abnormal umbilical cord blood vessels (HP:0011403)3.01191605
21Single umbilical artery (HP:0001195)3.01191605
22Abnormality of the fetal cardiovascular system (HP:0010948)3.01191605
23Abnormal ventriculo-arterial connection (HP:0011563)2.99752233
24Transposition of the great arteries (HP:0001669)2.99752233
25Abnormal connection of the cardiac segments (HP:0011545)2.99752233
26Protrusio acetabuli (HP:0003179)2.88060781
27Periauricular skin pits (HP:0100277)2.87441985
28Preauricular pit (HP:0004467)2.87441985
29Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.82973863
30Short 4th metacarpal (HP:0010044)2.82973863
31Abnormality of the umbilical cord (HP:0010881)2.81361004
32Broad distal phalanx of finger (HP:0009836)2.79916796
33Concave nail (HP:0001598)2.78831102
34Mediastinal lymphadenopathy (HP:0100721)2.71344664
35Turricephaly (HP:0000262)2.67013550
36Testicular atrophy (HP:0000029)2.64815293
37Abnormality of the distal phalanges of the toes (HP:0010182)2.63161039
38Renal duplication (HP:0000075)2.56258966
39Abnormality of the calcaneus (HP:0008364)2.56200639
40Abnormality of the nasal septum (HP:0000419)2.51216280
41Wrist flexion contracture (HP:0001239)2.43581960
42Coronal craniosynostosis (HP:0004440)2.39446987
43Progressive muscle weakness (HP:0003323)2.35064033
44Abnormality of the nasolacrimal system (HP:0000614)2.33901055
45Shallow orbits (HP:0000586)2.33568379
46Anal stenosis (HP:0002025)2.33165431
47Skin pits (HP:0100276)2.32841678
48Aplasia cutis congenita (HP:0001057)2.31717200
49Exercise-induced myalgia (HP:0003738)2.31538889
50Microretrognathia (HP:0000308)2.31403818
51Myopathic facies (HP:0002058)2.27839764
52Nasolacrimal duct obstruction (HP:0000579)2.26615746
53Subaortic stenosis (HP:0001682)2.22095867
54Abnormality of the left ventricular outflow tract (HP:0011103)2.22095867
55Annular pancreas (HP:0001734)2.21779299
56Renal dysplasia (HP:0000110)2.21331211
57Mesomelia (HP:0003027)2.19609706
58Spinal cord lesions (HP:0100561)2.19351786
59Syringomyelia (HP:0003396)2.19351786
60Bilateral microphthalmos (HP:0007633)2.17800348
61Broad toe (HP:0001837)2.15977604
62Truncus arteriosus (HP:0001660)2.14081521
63Abnormality of the lacrimal duct (HP:0011481)2.11911548
64Patellar dislocation (HP:0002999)2.11348106
65Peritonitis (HP:0002586)2.10800776
66Prostate neoplasm (HP:0100787)2.08115619
67Ulnar bowing (HP:0003031)2.06720455
68Short clavicles (HP:0000894)2.04778099
69Abnormality of the peritoneum (HP:0002585)2.04717514
70Trigonocephaly (HP:0000243)2.04425878
71Premature rupture of membranes (HP:0001788)2.03956703
72Rectal prolapse (HP:0002035)2.02995732
73Short middle phalanx of the 5th finger (HP:0004220)2.02911122
74Abnormality of the parathyroid morphology (HP:0011766)2.02907640
75Hyperthyroidism (HP:0000836)2.02020944
76Partial duplication of the phalanx of hand (HP:0009999)2.01380918
77Hypoplastic heart (HP:0001961)2.01277769
78Abnormality of the 4th metacarpal (HP:0010012)2.00969746
79Abnormal number of incisors (HP:0011064)2.00291130
80Abnormal autonomic nervous system physiology (HP:0012332)2.00250650
81Cutaneous melanoma (HP:0012056)2.00161086
82Absent phalangeal crease (HP:0006109)1.99887052
83Germ cell neoplasia (HP:0100728)1.98241513
84Hypoparathyroidism (HP:0000829)1.97664553
85Hypoplastic left heart (HP:0004383)1.96863905
86Dysmetric saccades (HP:0000641)1.95576958
87Upper limb muscle weakness (HP:0003484)1.95268366
88Genu recurvatum (HP:0002816)1.94270661
89Natal tooth (HP:0000695)1.93514536
90Increased number of teeth (HP:0011069)1.93439523
91Lip pit (HP:0100267)1.93430647
92Elbow flexion contracture (HP:0002987)1.93297079
93Trismus (HP:0000211)1.93261225
94Atelectasis (HP:0100750)1.93062362
95Self-mutilation (HP:0000742)1.92368340
96Anophthalmia (HP:0000528)1.91479790
97Bladder diverticulum (HP:0000015)1.88303194
98Rib fusion (HP:0000902)1.88203870
99Abnormality of chromosome segregation (HP:0002916)1.88044092
100Depressed nasal tip (HP:0000437)1.87770545
101Atresia of the external auditory canal (HP:0000413)1.87167475
102Redundant skin (HP:0001582)1.86664407
103Asymmetry of the thorax (HP:0001555)1.85309364
104Large earlobe (HP:0009748)1.84829951
105Recurrent corneal erosions (HP:0000495)1.84441940
106Ulnar claw (HP:0001178)1.84427911
107Type 1 muscle fiber predominance (HP:0003803)1.84392845
108Thin bony cortex (HP:0002753)1.84349381
109Dislocated radial head (HP:0003083)1.84178280
110Abnormality of the radial head (HP:0003995)1.84014690
111Down-sloping shoulders (HP:0200021)1.82333681
112Deviation of the hallux (HP:0010051)1.82169160
113Vertebral compression fractures (HP:0002953)1.81861861
114Bifid scrotum (HP:0000048)1.81712854
115High anterior hairline (HP:0009890)1.81631114
116Abnormality of the neuromuscular junction (HP:0003398)1.81521360
117Fatigable weakness (HP:0003473)1.81521360
118Breast hypoplasia (HP:0003187)1.81465624
119Hypoplasia of the iris (HP:0007676)1.80813660
120Hallux valgus (HP:0001822)1.80709546
121Atrophic scars (HP:0001075)1.80553945
122Calcaneovalgus deformity (HP:0001848)1.80492249
123Hypoventilation (HP:0002791)1.80407752
124Distal lower limb amyotrophy (HP:0008944)1.79353925
125Hypotrichosis (HP:0001006)1.78660703
126Overriding aorta (HP:0002623)1.78504223
127Chromosomal breakage induced by crosslinking agents (HP:0003221)1.77996513
128Slender long bone (HP:0003100)1.77740444
129Aplasia/Hypoplasia of the clavicles (HP:0006710)1.76875327
130Abnormalities of placenta or umbilical cord (HP:0001194)1.76849560
131Reduced subcutaneous adipose tissue (HP:0003758)1.76169854
132Morphological abnormality of the middle ear (HP:0008609)1.76115164
133Supernumerary ribs (HP:0005815)1.75661546
134Adducted thumb (HP:0001181)1.75576133
135Premature skin wrinkling (HP:0100678)1.75469883
136Chromsome breakage (HP:0040012)1.74306422
137Abnormality of the columella (HP:0009929)1.74101063
138Achilles tendon contracture (HP:0001771)1.73989142
139Abnormality of the aortic arch (HP:0012303)1.73569752
140Increased nuchal translucency (HP:0010880)1.73094374
141Birth length less than 3rd percentile (HP:0003561)1.71710226
142Anhidrosis (HP:0000970)1.71663394
143Round ear (HP:0100830)1.70999055
144Broad hallux (HP:0010055)1.69853845
145Preauricular skin tag (HP:0000384)1.67892247
146Premature loss of primary teeth (HP:0006323)1.67860686
147Abnormality of the fingertips (HP:0001211)1.67456716
148Insomnia (HP:0100785)1.65928715
149Oligodontia (HP:0000677)1.65594488
150Hypercalcemia (HP:0003072)1.63982533
151Elfin facies (HP:0004428)1.63948007
152Protruding ear (HP:0000411)1.63558209
153Recurrent skin infections (HP:0001581)1.60423102
154Short 5th finger (HP:0009237)1.60333348
155Sparse lateral eyebrow (HP:0005338)1.59576535
156Malignant hyperthermia (HP:0002047)1.59551134
157Eczematoid dermatitis (HP:0000976)1.57865827
158Distal lower limb muscle weakness (HP:0009053)1.57667492
159Broad metatarsal (HP:0001783)1.57441163
160Fragile skin (HP:0001030)1.57114607
161Shoulder girdle muscle weakness (HP:0003547)1.55979240
162Progressive sensorineural hearing impairment (HP:0000408)1.53310111
163Deformed tarsal bones (HP:0008119)1.53083011
164Broad thumb (HP:0011304)1.52048632
165Broad palm (HP:0001169)1.51570664
166Selective tooth agenesis (HP:0001592)1.51318111
167Vesicoureteral reflux (HP:0000076)1.50838578
168Hip contracture (HP:0003273)1.50721224
169Abnormality of the incisor (HP:0000676)1.48932804
170Supernumerary bones of the axial skeleton (HP:0009144)1.48324761
171Abnormality of the distal phalanx of the thumb (HP:0009617)1.47916741
172Cutaneous finger syndactyly (HP:0010554)1.47400051
173Soft skin (HP:0000977)1.47143646
174Exotropia (HP:0000577)1.46628505
175Milia (HP:0001056)1.45393419
176Advanced eruption of teeth (HP:0006288)1.44301531

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG14.13660049
2EEF2K4.04754022
3NME23.55698515
4CASK2.97684420
5TLK12.48744007
6BMX2.42829597
7LATS12.40647577
8GRK72.27831700
9MAP3K142.25481236
10CDK122.24763664
11TIE12.21554965
12ICK2.17321255
13RIPK42.10768053
14MATK2.08897223
15EPHB22.07022264
16IRAK32.04545283
17DDR22.03741936
18BUB11.99793995
19PKN21.95619403
20PRKD31.90886349
21LATS21.83420218
22PRPF4B1.78685770
23IKBKB1.75154723
24PDGFRA1.73945809
25YES11.73382814
26NTRK11.67586095
27VRK21.66638439
28LIMK11.66070409
29TTN1.61550328
30MKNK21.59120196
31MAP3K101.54198867
32TRPM71.52027725
33ADRBK11.49328052
34CHUK1.44298551
35ERBB31.42619275
36PIM21.41733423
37EIF2AK21.40474528
38TSSK61.37997558
39CDK41.36571982
40CHEK21.33800047
41CAMK1D1.33349001
42IRAK11.32083309
43MKNK11.31084104
44IRAK21.27708466
45ADRBK21.25530882
46TXK1.21187861
47SCYL21.17048107
48SRPK11.14495277
49PTK21.13663315
50RPS6KA21.01185828
51MAPKAPK51.00427102
52BMPR1B1.00357152
53CHEK11.00241837
54AURKA0.99733509
55MUSK0.99670759
56MST1R0.98644894
57ATR0.98316170
58RPS6KB20.97090361
59PAK40.96432109
60JAK30.95996135
61TAF10.95835724
62MAP3K120.93915157
63AKT20.93739851
64ARAF0.91851996
65IRAK40.91660142
66TBK10.88959777
67FGFR10.88933236
68BRAF0.88902802
69CDK90.86987523
70PNCK0.86864238
71MAPK110.86443657
72GRK50.86295902
73BLK0.85502072
74FGR0.81621066
75CDK70.81458517
76MAP2K20.81148380
77PAK20.80724359
78SIK10.79247433
79SIK20.79074235
80PDGFRB0.77444902
81BRD40.76447792
82CLK10.76433267
83IKBKE0.76029716
84RIPK10.74549683
85DMPK0.74459657
86RPS6KA40.73881619
87PDPK10.73528557
88STK30.73479869
89ERBB20.73181884
90LRRK20.73067241
91CAMK1G0.72100935
92MTOR0.71796547
93ERN10.68911609
94RPS6KC10.68590682
95RPS6KL10.68590682
96TAOK20.68444975
97BRSK10.68106457
98CDC70.67558951
99CDK80.67182399
100MELK0.67030033
101MAP3K130.64828571
102AKT10.64678305
103WNK10.64415349
104CDK30.64292340
105CDK20.63614607
106GSK3A0.62050197
107RPS6KA60.60486877
108NTRK20.60367625
109PRKCE0.60030067
110TGFBR10.59963266
111CDC42BPA0.58705945
112STK390.58600394
113PTK60.58586001
114DYRK30.58366272
115AKT30.58006412
116TTK0.56187203
117CDK60.56075257
118CDK11A0.55204693
119MOS0.54653266
120KSR20.51992770
121DYRK20.51830405
122WEE10.51337400
123MAP3K80.51135093
124CDK150.51077591
125CDK10.51044702
126MAP2K10.50549146
127WNK40.50222382
128PRKD20.49775401
129NEK90.49587769
130STK160.49529116
131AURKB0.49204601
132PRKCI0.48364399
133FGFR30.47768286
134PHKG10.47701791
135PHKG20.47701791
136UHMK10.47035867
137INSR0.46182558
138PRKAA20.45853125
139CDK180.45639550
140EPHA30.45017984
141JAK10.44601562
142MAPK80.43876847
143RPS6KA10.43832954
144SRC0.42311011
145GRK10.41742642
146ILK0.41566991
147MAPK10.40575668
148PLK10.40392830
149TGFBR20.40368757
150HIPK20.40254688
151STK40.38862278
152MAP2K30.38723567
153INSRR0.38479674
154FGFR40.37655435
155TESK10.36685916
156CSF1R0.36408087
157MAP3K110.36396305
158CSNK1A1L0.36303432
159KDR0.35764529
160MAP3K90.35667203
161MAPK140.35594752
162TRIB30.35593163
163ATM0.35272131
164EIF2AK10.34155141
165CCNB10.33239974
166TYRO30.33142144
167CDK140.32650689

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.21525143
2Sulfur relay system_Homo sapiens_hsa041222.91566593
3Ribosome_Homo sapiens_hsa030102.36890269
4One carbon pool by folate_Homo sapiens_hsa006702.23675912
5Spliceosome_Homo sapiens_hsa030402.15913261
6Leishmaniasis_Homo sapiens_hsa051402.15667580
7Base excision repair_Homo sapiens_hsa034102.11243326
8Cell cycle_Homo sapiens_hsa041101.96266677
9Basal cell carcinoma_Homo sapiens_hsa052171.94533872
10Non-small cell lung cancer_Homo sapiens_hsa052231.93883820
11Graft-versus-host disease_Homo sapiens_hsa053321.93226344
12Legionellosis_Homo sapiens_hsa051341.80919802
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.77681131
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.75450098
15Lysine degradation_Homo sapiens_hsa003101.72106467
16RNA transport_Homo sapiens_hsa030131.71921125
17Hedgehog signaling pathway_Homo sapiens_hsa043401.71394846
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.71125544
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.65537535
20mRNA surveillance pathway_Homo sapiens_hsa030151.65095078
21Rheumatoid arthritis_Homo sapiens_hsa053231.64751525
22Pyrimidine metabolism_Homo sapiens_hsa002401.62805615
23Allograft rejection_Homo sapiens_hsa053301.62109869
24Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.54044972
25Nucleotide excision repair_Homo sapiens_hsa034201.52008789
26Asthma_Homo sapiens_hsa053101.50957028
27Malaria_Homo sapiens_hsa051441.50748200
28Mismatch repair_Homo sapiens_hsa034301.48537421
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.48090649
30Thyroid cancer_Homo sapiens_hsa052161.44514296
31Glioma_Homo sapiens_hsa052141.44319919
32TNF signaling pathway_Homo sapiens_hsa046681.43633855
33TGF-beta signaling pathway_Homo sapiens_hsa043501.43210489
34AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.43153257
35Cyanoamino acid metabolism_Homo sapiens_hsa004601.40826947
36Toll-like receptor signaling pathway_Homo sapiens_hsa046201.40604109
37Central carbon metabolism in cancer_Homo sapiens_hsa052301.40341846
38MicroRNAs in cancer_Homo sapiens_hsa052061.40182439
39Endometrial cancer_Homo sapiens_hsa052131.37878988
40Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.37330276
41Salmonella infection_Homo sapiens_hsa051321.34289508
42Hippo signaling pathway_Homo sapiens_hsa043901.32509026
43Proteoglycans in cancer_Homo sapiens_hsa052051.31962343
44Pertussis_Homo sapiens_hsa051331.30736542
45Small cell lung cancer_Homo sapiens_hsa052221.29756941
46Measles_Homo sapiens_hsa051621.29148238
47Chronic myeloid leukemia_Homo sapiens_hsa052201.26094956
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.26066172
49AMPK signaling pathway_Homo sapiens_hsa041521.24589827
50Thyroid hormone signaling pathway_Homo sapiens_hsa049191.23628454
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.23230461
52Tuberculosis_Homo sapiens_hsa051521.23026277
53VEGF signaling pathway_Homo sapiens_hsa043701.19994582
54Amoebiasis_Homo sapiens_hsa051461.19791306
55RNA polymerase_Homo sapiens_hsa030201.19078611
56Notch signaling pathway_Homo sapiens_hsa043301.18899118
57Toxoplasmosis_Homo sapiens_hsa051451.18821084
58Phagosome_Homo sapiens_hsa041451.18602151
59African trypanosomiasis_Homo sapiens_hsa051431.17712223
60Osteoclast differentiation_Homo sapiens_hsa043801.17596872
61Apoptosis_Homo sapiens_hsa042101.15555518
62Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.14300522
63Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.13037757
64Axon guidance_Homo sapiens_hsa043601.12132100
65Herpes simplex infection_Homo sapiens_hsa051681.11236828
66Hematopoietic cell lineage_Homo sapiens_hsa046401.11117909
67Phenylalanine metabolism_Homo sapiens_hsa003601.10967138
68Transcriptional misregulation in cancer_Homo sapiens_hsa052021.10647301
69Neurotrophin signaling pathway_Homo sapiens_hsa047221.09953956
70Insulin signaling pathway_Homo sapiens_hsa049101.08970249
71Biosynthesis of amino acids_Homo sapiens_hsa012301.08822097
72Renal cell carcinoma_Homo sapiens_hsa052111.08457456
73Homologous recombination_Homo sapiens_hsa034401.08216199
74ECM-receptor interaction_Homo sapiens_hsa045121.05959434
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.05438155
76Adherens junction_Homo sapiens_hsa045201.02563041
77Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.01996346
78Choline metabolism in cancer_Homo sapiens_hsa052311.01811377
79HTLV-I infection_Homo sapiens_hsa051661.01374723
80Influenza A_Homo sapiens_hsa051640.99121443
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.98922430
82Vitamin B6 metabolism_Homo sapiens_hsa007500.98736843
83Epstein-Barr virus infection_Homo sapiens_hsa051690.98534676
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.97680753
85Cholinergic synapse_Homo sapiens_hsa047250.97398942
86Pathways in cancer_Homo sapiens_hsa052000.96253071
87Focal adhesion_Homo sapiens_hsa045100.96022035
88Wnt signaling pathway_Homo sapiens_hsa043100.95623832
89Colorectal cancer_Homo sapiens_hsa052100.94867117
902-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.94756747
91Melanoma_Homo sapiens_hsa052180.93495669
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.93120835
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.90915345
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.90047868
95Tyrosine metabolism_Homo sapiens_hsa003500.89125715
96Fanconi anemia pathway_Homo sapiens_hsa034600.88829988
97Prolactin signaling pathway_Homo sapiens_hsa049170.88107405
98Type I diabetes mellitus_Homo sapiens_hsa049400.85750708
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85668920
100Hepatitis B_Homo sapiens_hsa051610.84540968
101Viral myocarditis_Homo sapiens_hsa054160.82919175
102Regulation of actin cytoskeleton_Homo sapiens_hsa048100.82609936
103Chemokine signaling pathway_Homo sapiens_hsa040620.82269603
104PI3K-Akt signaling pathway_Homo sapiens_hsa041510.81511799
105Fructose and mannose metabolism_Homo sapiens_hsa000510.81476624
106Acute myeloid leukemia_Homo sapiens_hsa052210.80953901
107Prostate cancer_Homo sapiens_hsa052150.79829622
108Pancreatic cancer_Homo sapiens_hsa052120.78736185
109Jak-STAT signaling pathway_Homo sapiens_hsa046300.78077991
110Steroid biosynthesis_Homo sapiens_hsa001000.78003446
111Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.75928966
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75128128
113Intestinal immune network for IgA production_Homo sapiens_hsa046720.74799660
114Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.74023813
115Ovarian steroidogenesis_Homo sapiens_hsa049130.73125570
116Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72638895
117Shigellosis_Homo sapiens_hsa051310.72080888
118FoxO signaling pathway_Homo sapiens_hsa040680.72037231
119MAPK signaling pathway_Homo sapiens_hsa040100.70502281
120ErbB signaling pathway_Homo sapiens_hsa040120.70289056
121Bladder cancer_Homo sapiens_hsa052190.69905685
122Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.69707300
123Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.69232988
124Rap1 signaling pathway_Homo sapiens_hsa040150.68833955
125Viral carcinogenesis_Homo sapiens_hsa052030.66180412
126Melanogenesis_Homo sapiens_hsa049160.65685904
127T cell receptor signaling pathway_Homo sapiens_hsa046600.65339267
128Purine metabolism_Homo sapiens_hsa002300.64836514
129Selenocompound metabolism_Homo sapiens_hsa004500.64698939
130Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64698735
131Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63202202
132Cysteine and methionine metabolism_Homo sapiens_hsa002700.62183642
133mTOR signaling pathway_Homo sapiens_hsa041500.61100275
134GnRH signaling pathway_Homo sapiens_hsa049120.59911585
135Adipocytokine signaling pathway_Homo sapiens_hsa049200.59475092
136Glucagon signaling pathway_Homo sapiens_hsa049220.59004472
137Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58855458
138Prion diseases_Homo sapiens_hsa050200.58688657
139Arginine and proline metabolism_Homo sapiens_hsa003300.58242233
140Platelet activation_Homo sapiens_hsa046110.58153111
141Estrogen signaling pathway_Homo sapiens_hsa049150.57912145
142Non-homologous end-joining_Homo sapiens_hsa034500.57071658
143Antigen processing and presentation_Homo sapiens_hsa046120.57040046
144B cell receptor signaling pathway_Homo sapiens_hsa046620.56494298
145Sphingolipid signaling pathway_Homo sapiens_hsa040710.56468446
146p53 signaling pathway_Homo sapiens_hsa041150.56173083
147Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54971419
148Hepatitis C_Homo sapiens_hsa051600.54549146
149Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54355406
150Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53436228
151Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50429147
152Pentose phosphate pathway_Homo sapiens_hsa000300.49588239
153Oocyte meiosis_Homo sapiens_hsa041140.48201379
154Endocytosis_Homo sapiens_hsa041440.44267309
155Phospholipase D signaling pathway_Homo sapiens_hsa040720.40715043
156Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40523287
157Insulin resistance_Homo sapiens_hsa049310.40247757
158cGMP-PKG signaling pathway_Homo sapiens_hsa040220.39463330

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