HOXC11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene binds to a promoter element of the lactase-phlorizin hydrolase. It also may play a role in early intestinal development. An alternatively spliced variant encoding a shorter isoform has been described but its full-length nature has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)7.32757281
2muscle cell fate commitment (GO:0042693)5.08221692
3proline metabolic process (GO:0006560)5.07429699
4establishment of apical/basal cell polarity (GO:0035089)4.95751215
5embryonic process involved in female pregnancy (GO:0060136)4.95532050
6transcription from mitochondrial promoter (GO:0006390)4.90867336
7embryonic camera-type eye development (GO:0031076)4.67985451
8* embryonic skeletal joint morphogenesis (GO:0060272)4.62491282
9uterus development (GO:0060065)4.48221745
10regulation of mammary gland epithelial cell proliferation (GO:0033599)4.45182550
11regulation of integrin activation (GO:0033623)4.38703781
12actin-myosin filament sliding (GO:0033275)4.29816286
13muscle filament sliding (GO:0030049)4.29816286
14regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.25838442
15plasma membrane repair (GO:0001778)4.24328738
16* proximal/distal pattern formation (GO:0009954)4.23041614
17embryonic forelimb morphogenesis (GO:0035115)4.19539615
18establishment of monopolar cell polarity (GO:0061162)4.19413732
19establishment or maintenance of monopolar cell polarity (GO:0061339)4.19413732
20skeletal muscle contraction (GO:0003009)4.15412960
21metanephric mesenchyme development (GO:0072075)4.06630688
22kidney mesenchyme development (GO:0072074)4.06385110
23negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.02250347
24positive regulation of protein homooligomerization (GO:0032464)3.97068980
25mammary gland epithelial cell differentiation (GO:0060644)3.93376070
26mitotic G1 DNA damage checkpoint (GO:0031571)3.88832847
27intestinal epithelial cell development (GO:0060576)3.88771678
28protein heterotrimerization (GO:0070208)3.85462610
29skeletal muscle fiber development (GO:0048741)3.75184542
30mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.74367218
31replication fork processing (GO:0031297)3.72946359
32forelimb morphogenesis (GO:0035136)3.72086441
33paraxial mesoderm development (GO:0048339)3.70135377
34negative regulation of chondrocyte differentiation (GO:0032331)3.69510271
35regulation of apoptotic process involved in morphogenesis (GO:1902337)3.67303708
36prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.66607838
37positive regulation of myotube differentiation (GO:0010831)3.64314806
38face development (GO:0060324)3.63139010
39actin-mediated cell contraction (GO:0070252)3.60032486
40convergent extension (GO:0060026)3.52147986
41outer ear morphogenesis (GO:0042473)3.51069294
42outflow tract septum morphogenesis (GO:0003148)3.48362623
43embryonic cranial skeleton morphogenesis (GO:0048701)3.48329920
44eyelid development in camera-type eye (GO:0061029)3.44811174
45G1 DNA damage checkpoint (GO:0044783)3.44365976
46regulation of protein homooligomerization (GO:0032462)3.40410009
47oxidative demethylation (GO:0070989)3.40352865
48COPI coating of Golgi vesicle (GO:0048205)3.39876379
49Golgi transport vesicle coating (GO:0048200)3.39876379
50myoblast fusion (GO:0007520)3.39841794
51glial cell migration (GO:0008347)3.38686399
52* embryonic skeletal system morphogenesis (GO:0048704)3.37311232
53polarized epithelial cell differentiation (GO:0030859)3.36056341
54* organ induction (GO:0001759)3.35094101
55regulation of skeletal muscle contraction (GO:0014819)3.33801121
56negative regulation of cartilage development (GO:0061037)3.32825143
57mitotic G1/S transition checkpoint (GO:0044819)3.32563969
58lymph vessel development (GO:0001945)3.31836150
59spliceosomal tri-snRNP complex assembly (GO:0000244)3.28953051
60epithelial cell maturation (GO:0002070)3.28364035
61regulation of hippo signaling (GO:0035330)3.24839287
62collagen fibril organization (GO:0030199)3.24283603
63negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.20548734
64myoblast migration (GO:0051451)3.19760899
65negative regulation of JAK-STAT cascade (GO:0046426)3.13222815
66syncytium formation by plasma membrane fusion (GO:0000768)3.11841531
67negative regulation of cell cycle arrest (GO:0071157)3.10743194
68maturation of SSU-rRNA (GO:0030490)3.10661503
69regulation of translational fidelity (GO:0006450)3.08617227
70ear development (GO:0043583)3.07014583
71branching involved in mammary gland duct morphogenesis (GO:0060444)3.05413341
72poly(A)+ mRNA export from nucleus (GO:0016973)3.03858670
73cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.02882157
74planar cell polarity pathway involved in neural tube closure (GO:0090179)3.01838491
75embryonic placenta development (GO:0001892)3.01454121
76vagina development (GO:0060068)3.00857942
77syncytium formation (GO:0006949)3.00543751
78middle ear morphogenesis (GO:0042474)2.99815754
79protein localization to endosome (GO:0036010)2.99474430
80regulation of chromatin binding (GO:0035561)2.97533931
81nuclear pore complex assembly (GO:0051292)2.96478028
82* regulation of organ formation (GO:0003156)2.96131819
83mitotic sister chromatid cohesion (GO:0007064)2.95640493
84positive regulation of keratinocyte differentiation (GO:0045618)2.94107239
85positive regulation of protein oligomerization (GO:0032461)2.93810278
86DNA synthesis involved in DNA repair (GO:0000731)2.93370432
87ribosomal small subunit biogenesis (GO:0042274)2.93117967
88actin filament-based movement (GO:0030048)2.92946130
89anatomical structure regression (GO:0060033)2.92389095
90regulation of secondary heart field cardioblast proliferation (GO:0003266)2.90453932
91regulation of cardioblast proliferation (GO:0003264)2.90453932
92cochlea morphogenesis (GO:0090103)2.90204077
93maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.89358256
94myotube cell development (GO:0014904)2.88917946
95cranial nerve morphogenesis (GO:0021602)2.87804684
96regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.87564465
97embryonic eye morphogenesis (GO:0048048)2.86083040
98neural crest cell development (GO:0014032)2.85698947
99regulation of fatty acid beta-oxidation (GO:0031998)2.84552162
100endocardial cushion development (GO:0003197)2.84207668
101desmosome organization (GO:0002934)2.82429104
102negative regulation of Ras GTPase activity (GO:0034261)2.82068487
103mitotic chromosome condensation (GO:0007076)2.81264493
104branching involved in prostate gland morphogenesis (GO:0060442)2.79882233
105regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.78141881
106regulation of heart morphogenesis (GO:2000826)2.78091177
107nuclear envelope reassembly (GO:0031468)2.77004589
108mitotic nuclear envelope reassembly (GO:0007084)2.77004589
109peripheral nervous system neuron development (GO:0048935)2.74149836
110negative regulation of mRNA processing (GO:0050686)2.73954265
111DNA deamination (GO:0045006)2.72880351
112female genitalia development (GO:0030540)2.72284909
113peptidyl-proline hydroxylation (GO:0019511)2.70280690
114mitochondrial DNA metabolic process (GO:0032042)2.69337420
115* skeletal system morphogenesis (GO:0048705)2.69163321
116mitotic sister chromatid segregation (GO:0000070)2.68927830
117atrioventricular valve morphogenesis (GO:0003181)2.68676268
118adherens junction assembly (GO:0034333)2.68215026
119skeletal muscle adaptation (GO:0043501)2.67431257
120apoptotic process involved in morphogenesis (GO:0060561)2.67387674
121chondrocyte proliferation (GO:0035988)2.67382545
122embryonic appendage morphogenesis (GO:0035113)2.66398773
123embryonic limb morphogenesis (GO:0030326)2.66398773
124positive regulation of Rho protein signal transduction (GO:0035025)2.66369266
125viral mRNA export from host cell nucleus (GO:0046784)2.66220485
126mesenchymal to epithelial transition (GO:0060231)2.66149916
127DNA replication checkpoint (GO:0000076)2.66047439
128negative regulation of cell size (GO:0045792)2.66046220
129neuron fate specification (GO:0048665)2.65852280
130base-excision repair (GO:0006284)2.64826857
131* embryonic organ morphogenesis (GO:0048562)2.63481951
132mammary gland epithelial cell proliferation (GO:0033598)2.62072071
133regulation of cell proliferation involved in kidney development (GO:1901722)2.61920193
134regulation of posttranscriptional gene silencing (GO:0060147)2.59711406
135regulation of gene silencing by miRNA (GO:0060964)2.59711406
136regulation of gene silencing by RNA (GO:0060966)2.59711406
137endocrine hormone secretion (GO:0060986)2.59690505
138cellular response to ATP (GO:0071318)2.59230175
139folic acid metabolic process (GO:0046655)2.58475299
140pharyngeal system development (GO:0060037)2.58321782
141positive regulation of odontogenesis (GO:0042482)2.57872244
142hippo signaling (GO:0035329)2.56512023
143embryonic body morphogenesis (GO:0010172)2.56505837
144formation of translation preinitiation complex (GO:0001731)2.56384400
145bone trabecula formation (GO:0060346)2.55786600
146regulation of cell size (GO:0008361)2.55435961
147cell-substrate adherens junction assembly (GO:0007045)2.55235930
148focal adhesion assembly (GO:0048041)2.55235930
149regulation of cartilage development (GO:0061035)2.55199154
150membrane tubulation (GO:0097320)2.54706541
151diaphragm development (GO:0060539)2.54301972
152nucleobase-containing small molecule interconversion (GO:0015949)2.53111481
153midgut development (GO:0007494)2.52900448
154maternal placenta development (GO:0001893)2.52717136
155protein hydroxylation (GO:0018126)2.52426438
156nuclear pore organization (GO:0006999)2.52398929
157regulation of cardioblast differentiation (GO:0051890)2.52002649
158positive regulation of chondrocyte differentiation (GO:0032332)2.51279285
159negative regulation of embryonic development (GO:0045992)2.51185716
160mesonephros development (GO:0001823)2.49532561
161endocardial cushion morphogenesis (GO:0003203)2.49064607
162regulation of protein heterodimerization activity (GO:0043497)2.49055137
163negative regulation of fatty acid transport (GO:2000192)2.49036618
164synaptonemal complex assembly (GO:0007130)2.48821526
165positive regulation of cartilage development (GO:0061036)2.48761074
166regulation of translational termination (GO:0006449)2.47625516
167cellular response to interferon-alpha (GO:0035457)2.47331526
168epithelial cell-cell adhesion (GO:0090136)2.46936763
169body morphogenesis (GO:0010171)2.46203329
170protein retention in ER lumen (GO:0006621)2.45586676
171GDP-mannose metabolic process (GO:0019673)2.44737489
172regulation of sister chromatid cohesion (GO:0007063)2.44672277
173skeletal muscle tissue regeneration (GO:0043403)2.44651781
174somatic hypermutation of immunoglobulin genes (GO:0016446)2.44429603
175mammary gland alveolus development (GO:0060749)2.42407407
176intracellular estrogen receptor signaling pathway (GO:0030520)2.40666204
177regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.39774590
178regulation of water loss via skin (GO:0033561)2.39537030
179ribosome biogenesis (GO:0042254)2.39117390
180negative regulation of kidney development (GO:0090185)2.38529568
181protein complex localization (GO:0031503)2.36343462
182embryonic camera-type eye morphogenesis (GO:0048596)2.34917416

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.49858573
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.57077677
3ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.32962768
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.30606140
5STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.86192548
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.85119282
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.85119282
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.85119282
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.85004475
10ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.74300172
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.52162738
12NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.47697617
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.32631288
14XRN2_22483619_ChIP-Seq_HELA_Human2.29218945
15SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.28140708
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.24309496
17RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.20284931
18LXR_22292898_ChIP-Seq_THP-1_Human2.18237098
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.12710200
20VDR_21846776_ChIP-Seq_THP-1_Human2.10119900
21MYC_18555785_ChIP-Seq_MESCs_Mouse2.09518393
22TP63_19390658_ChIP-ChIP_HaCaT_Human2.07909518
23SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.07852743
24ELK3_25401928_ChIP-Seq_HUVEC_Human2.05370796
25* RACK7_27058665_Chip-Seq_MCF-7_Human2.03083636
26ZFP281_18757296_ChIP-ChIP_E14_Mouse2.02480870
27DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.00690317
28KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.96548999
29* TP53_20018659_ChIP-ChIP_R1E_Mouse1.94995461
30FOXM1_23109430_ChIP-Seq_U2OS_Human1.94028788
31KDM5A_27292631_Chip-Seq_BREAST_Human1.90779908
32EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.90162123
33SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.87302205
34ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.85597145
35CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.84926663
36HIF1A_21447827_ChIP-Seq_MCF-7_Human1.82453758
37TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77873963
38EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.77460547
39P300_27058665_Chip-Seq_ZR-75-30cells_Human1.75612912
40E2F1_21310950_ChIP-Seq_MCF-7_Human1.73618835
41AR_21909140_ChIP-Seq_LNCAP_Human1.73571458
42JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.71701188
43KDM2B_26808549_Chip-Seq_SUP-B15_Human1.70819295
44POU5F1_16518401_ChIP-PET_MESCs_Mouse1.69863170
45* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.69798690
46DCP1A_22483619_ChIP-Seq_HELA_Human1.69520639
47TCF3_18692474_ChIP-Seq_MEFs_Mouse1.65994452
48ZFX_18555785_ChIP-Seq_MESCs_Mouse1.64294070
49MYC_19079543_ChIP-ChIP_MESCs_Mouse1.64138068
50HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.63807155
51KDM2B_26808549_Chip-Seq_DND41_Human1.63421226
52STAT3_1855785_ChIP-Seq_MESCs_Mouse1.63094832
53RUNX1_27514584_Chip-Seq_MCF-7_Human1.59382170
54PKCTHETA_26484144_Chip-Seq_BREAST_Human1.59183533
55SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.55242448
56KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.54356749
57TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.53234286
58KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.52051710
59* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.49957513
60TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.49649030
61TTF2_22483619_ChIP-Seq_HELA_Human1.48656856
62ATF3_27146783_Chip-Seq_COLON_Human1.48610699
63RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45065567
64TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.44694321
65TCF3_18692474_ChIP-Seq_MESCs_Mouse1.43713102
66NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.43692934
67CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.43040276
68WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.42320355
69KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.41065191
70NELFA_20434984_ChIP-Seq_ESCs_Mouse1.39289073
71* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.37318217
72TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36872711
73CTCF_27219007_Chip-Seq_ERYTHROID_Human1.34282635
74ERG_21242973_ChIP-ChIP_JURKAT_Human1.34134002
75MYC_22102868_ChIP-Seq_BL_Human1.33009146
76* TET1_21451524_ChIP-Seq_MESCs_Mouse1.32409434
77CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31535819
78CLOCK_20551151_ChIP-Seq_293T_Human1.31273312
79POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.30737074
80STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.30465679
81CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.30385766
82CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.30190850
83DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.28463401
84THAP11_20581084_ChIP-Seq_MESCs_Mouse1.27950982
85HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.27679577
86KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.27479426
87ESR1_20079471_ChIP-ChIP_T-47D_Human1.26809656
88MYCN_18555785_ChIP-Seq_MESCs_Mouse1.26476737
89PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.26066781
90NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.25602657
91KDM2B_26808549_Chip-Seq_K562_Human1.25127036
92CHD1_26751641_Chip-Seq_LNCaP_Human1.25121237
93PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.24239692
94CREB1_15753290_ChIP-ChIP_HEK293T_Human1.21586304
95GABP_19822575_ChIP-Seq_HepG2_Human1.21310892
96MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.21216564
97TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.20582324
98ZNF263_19887448_ChIP-Seq_K562_Human1.19659033
99KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19434588
100EGR1_19374776_ChIP-ChIP_THP-1_Human1.19244386
101TP53_22127205_ChIP-Seq_IMR90_Human1.19242062
102POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.19036599
103EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.18470265
104ESR1_21235772_ChIP-Seq_MCF-7_Human1.18047038
105E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15792497
106CREB1_26743006_Chip-Seq_LNCaP_Human1.15754773
107THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.15293881
108E2F4_17652178_ChIP-ChIP_JURKAT_Human1.15286566
109TP53_23651856_ChIP-Seq_MEFs_Mouse1.15071035
110CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.14200130
111* CBX2_27304074_Chip-Seq_ESCs_Mouse1.13919178
112NANOG_21062744_ChIP-ChIP_HESCs_Human1.13600702
113CTCF_21964334_ChIP-Seq_BJAB-B_Human1.13432920
114SA1_27219007_Chip-Seq_ERYTHROID_Human1.12487288
115SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.12405819
116KDM2B_26808549_Chip-Seq_JURKAT_Human1.12362230
117ESR2_21235772_ChIP-Seq_MCF-7_Human1.12262328
118ELF5_23300383_ChIP-Seq_T47D_Human1.12005072
119SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.10676061
120SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.10676061
121ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10335137
122ETS1_20019798_ChIP-Seq_JURKAT_Human1.09751295
123OCT4_18692474_ChIP-Seq_MEFs_Mouse1.09642246
124SOX2_18692474_ChIP-Seq_MEFs_Mouse1.09331217
125NFIB_24661679_ChIP-Seq_LUNG_Mouse1.09082557
126TCF7_22412390_ChIP-Seq_EML_Mouse1.09055517
127EED_16625203_ChIP-ChIP_MESCs_Mouse1.07869029
128ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.07855265
129E2F1_18555785_ChIP-Seq_MESCs_Mouse1.07694834
130TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07617953
131SOX2_18555785_ChIP-Seq_MESCs_Mouse1.06694842
132MYC_18358816_ChIP-ChIP_MESCs_Mouse1.06602101
133SMC1_22415368_ChIP-Seq_MEFs_Mouse1.06432887
134BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.05770507
135GATA3_24758297_ChIP-Seq_MCF-7_Human1.05742576
136KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05478530
137BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04378811
138NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.03745999
139TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.03581128
140TFEB_21752829_ChIP-Seq_HELA_Human1.03450423
141* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.02486738
142PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02167886
143NOTCH1_21737748_ChIP-Seq_TLL_Human1.01770852
144SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.00410327
145* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.99998856
146* RING1B_27294783_Chip-Seq_NPCs_Mouse0.99222850
147NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.98447693
148* EZH2_27304074_Chip-Seq_ESCs_Mouse0.97325016
149PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96943799
150CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96633766
151SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.96564356
152UBF1/2_26484160_Chip-Seq_HMECs_Human0.96118025

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology5.15392939
2MP0008438_abnormal_cutaneous_collagen4.27461517
3MP0004233_abnormal_muscle_weight3.93989824
4MP0003705_abnormal_hypodermis_morpholog3.36662311
5MP0009780_abnormal_chondrocyte_physiolo3.21530084
6MP0005503_abnormal_tendon_morphology2.96308003
7MP0000733_abnormal_muscle_development2.93019369
8MP0000751_myopathy2.82693647
9MP0004145_abnormal_muscle_electrophysio2.66723959
10MP0009278_abnormal_bone_marrow2.64127706
11MP0000750_abnormal_muscle_regeneration2.46397715
12MP0000749_muscle_degeneration2.41597706
13MP0002160_abnormal_reproductive_system2.38495668
14MP0005275_abnormal_skin_tensile2.33946318
15MP0002249_abnormal_larynx_morphology2.30450918
16MP0002108_abnormal_muscle_morphology2.29759094
17MP0009053_abnormal_anal_canal2.28996285
18MP0002269_muscular_atrophy2.26109565
19MP0005171_absent_coat_pigmentation2.22337735
20MP0000759_abnormal_skeletal_muscle2.19863090
21MP0002098_abnormal_vibrissa_morphology2.08126273
22MP0008057_abnormal_DNA_replication2.05921669
23MP0002106_abnormal_muscle_physiology2.01712593
24MP0003385_abnormal_body_wall1.99747500
25MP0009250_abnormal_appendicular_skeleto1.99449829
26MP0005623_abnormal_meninges_morphology1.96186558
27MP0000537_abnormal_urethra_morphology1.95673573
28MP0010352_gastrointestinal_tract_polyps1.94171662
29MP0005369_muscle_phenotype1.93063916
30MP0003693_abnormal_embryo_hatching1.89524614
31MP0002932_abnormal_joint_morphology1.84772080
32MP0000747_muscle_weakness1.83244832
33MP0003942_abnormal_urinary_system1.82533215
34MP0005076_abnormal_cell_differentiation1.82204030
35MP0004087_abnormal_muscle_fiber1.80406052
36MP0002796_impaired_skin_barrier1.79529709
37MP0005501_abnormal_skin_physiology1.73473459
38MP0009384_cardiac_valve_regurgitation1.72546671
39MP0003950_abnormal_plasma_membrane1.71940612
40MP0003279_aneurysm1.71746349
41MP0005508_abnormal_skeleton_morphology1.71425767
42MP0005083_abnormal_biliary_tract1.70334380
43MP0002282_abnormal_trachea_morphology1.68082292
44MP0010234_abnormal_vibrissa_follicle1.67211778
45MP0002877_abnormal_melanocyte_morpholog1.57057661
46MP0004264_abnormal_extraembryonic_tissu1.56114263
47MP0003111_abnormal_nucleus_morphology1.55940479
48MP0002114_abnormal_axial_skeleton1.47497124
49MP0005023_abnormal_wound_healing1.47454513
50MP0000534_abnormal_ureter_morphology1.45742578
51MP0002060_abnormal_skin_morphology1.45732814
52MP0003077_abnormal_cell_cycle1.45284088
53MP0003755_abnormal_palate_morphology1.40765073
54MP0000427_abnormal_hair_cycle1.36858605
55MP0004957_abnormal_blastocyst_morpholog1.36408368
56MP0000627_abnormal_mammary_gland1.34390800
57MP0002234_abnormal_pharynx_morphology1.32656669
58MP0000049_abnormal_middle_ear1.32030954
59MP0001348_abnormal_lacrimal_gland1.31841580
60MP0000762_abnormal_tongue_morphology1.31311214
61MP0004197_abnormal_fetal_growth/weight/1.29409227
62MP0001881_abnormal_mammary_gland1.27127639
63MP0001346_abnormal_lacrimal_gland1.24671177
64MP0002111_abnormal_tail_morphology1.24041350
65MP0001661_extended_life_span1.20966499
66MP0003283_abnormal_digestive_organ1.20961938
67MP0010094_abnormal_chromosome_stability1.20631014
68MP0005257_abnormal_intraocular_pressure1.20535542
69MP0000516_abnormal_urinary_system1.18097281
70MP0005367_renal/urinary_system_phenotyp1.18097281
71MP0003453_abnormal_keratinocyte_physiol1.15215568
72MP0005187_abnormal_penis_morphology1.13770124
73MP0000383_abnormal_hair_follicle1.13002198
74MP0000681_abnormal_thyroid_gland1.12863173
75MP0010307_abnormal_tumor_latency1.12367947
76MP0010678_abnormal_skin_adnexa1.10382478
77MP0003566_abnormal_cell_adhesion1.07444792
78MP0003119_abnormal_digestive_system1.07049763
79MP0003567_abnormal_fetal_cardiomyocyte1.04553155
80MP0002009_preneoplasia1.04521555
81MP0000428_abnormal_craniofacial_morphol1.03825583
82MP0004782_abnormal_surfactant_physiolog1.03298044
83MP0002084_abnormal_developmental_patter1.03106515
84MP0002116_abnormal_craniofacial_bone1.03068053
85MP0005389_reproductive_system_phenotype1.01219660
86MP0000163_abnormal_cartilage_morphology1.00728126
87MP0002115_abnormal_skeleton_extremities1.00172652
88MP0002085_abnormal_embryonic_tissue0.99952359
89MP0003315_abnormal_perineum_morphology0.98970689
90MP0003936_abnormal_reproductive_system0.98967162
91MP0002109_abnormal_limb_morphology0.98078441
92MP0003935_abnormal_craniofacial_develop0.97973126
93MP0010771_integument_phenotype0.97906740
94MP0004185_abnormal_adipocyte_glucose0.96713904
95MP0003786_premature_aging0.96587932
96MP0005330_cardiomyopathy0.96425702
97MP0004272_abnormal_basement_membrane0.95491134
98MP0001873_stomach_inflammation0.95264025
99MP0001340_abnormal_eyelid_morphology0.94147960
100MP0003937_abnormal_limbs/digits/tail_de0.93516945
101MP0001958_emphysema0.91261192
102MP0001542_abnormal_bone_strength0.90569269
103MP0000538_abnormal_urinary_bladder0.90487992
104MP0010630_abnormal_cardiac_muscle0.89597795
105MP0004134_abnormal_chest_morphology0.89075357
106MP0005248_abnormal_Harderian_gland0.88495978
107MP0004381_abnormal_hair_follicle0.88418678
108MP0000003_abnormal_adipose_tissue0.86751991
109MP0000013_abnormal_adipose_tissue0.86516467
110MP0008932_abnormal_embryonic_tissue0.86256010
111MP0003115_abnormal_respiratory_system0.85897956
112MP0002896_abnormal_bone_mineralization0.85019108
113MP0000432_abnormal_head_morphology0.84595453
114MP0001697_abnormal_embryo_size0.83234502
115MP0001727_abnormal_embryo_implantation0.83175506
116MP0002086_abnormal_extraembryonic_tissu0.82151759
117MP0008007_abnormal_cellular_replicative0.81659598
118MP0008058_abnormal_DNA_repair0.81249245
119MP0003646_muscle_fatigue0.80628531
120MP0000377_abnormal_hair_follicle0.79845977
121MP0001243_abnormal_dermal_layer0.79267607
122MP0005375_adipose_tissue_phenotype0.77850681
123MP0001545_abnormal_hematopoietic_system0.77583832
124MP0005397_hematopoietic_system_phenotyp0.77583832
125MP0002089_abnormal_postnatal_growth/wei0.76673136
126MP0001299_abnormal_eye_distance/0.75433929
127MP0003941_abnormal_skin_development0.74588641
128MP0003091_abnormal_cell_migration0.74281440
129MP0003045_fibrosis0.73164167
130MP0000579_abnormal_nail_morphology0.70920026
131MP0004133_heterotaxia0.69445267
132MP0000678_abnormal_parathyroid_gland0.69131656
133MP0000767_abnormal_smooth_muscle0.69128924
134MP0002113_abnormal_skeleton_development0.68604341
135MP0000467_abnormal_esophagus_morphology0.67759601
136MP0001293_anophthalmia0.67583873
137MP0002332_abnormal_exercise_endurance0.65886281
138MP0002697_abnormal_eye_size0.65399786
139MP0000350_abnormal_cell_proliferation0.64445102
140MP0005390_skeleton_phenotype0.64289745
141MP0005380_embryogenesis_phenotype0.64251541
142MP0001672_abnormal_embryogenesis/_devel0.64251541

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)5.61421678
2Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.54915018
3Type 1 muscle fiber predominance (HP:0003803)5.34375257
4Septate vagina (HP:0001153)5.23803785
5Sparse lateral eyebrow (HP:0005338)5.13614172
6Nemaline bodies (HP:0003798)5.12653552
7Round ear (HP:0100830)4.41115088
8Popliteal pterygium (HP:0009756)4.35629808
9Fetal akinesia sequence (HP:0001989)4.35450730
10Protrusio acetabuli (HP:0003179)4.26741843
11Calcaneovalgus deformity (HP:0001848)4.21926193
12Distal arthrogryposis (HP:0005684)4.20419336
13Premature rupture of membranes (HP:0001788)4.13127648
14Amniotic constriction ring (HP:0009775)4.09765680
15Abnormality of placental membranes (HP:0011409)4.09765680
16Deformed tarsal bones (HP:0008119)4.03905384
17Lip pit (HP:0100267)3.97560362
18Abnormality of the neuromuscular junction (HP:0003398)3.82235339
19Fatigable weakness (HP:0003473)3.82235339
20Malignant hyperthermia (HP:0002047)3.79689534
21Type 2 muscle fiber atrophy (HP:0003554)3.71971115
22Aplasia of the musculature (HP:0100854)3.71300273
23Muscle fiber atrophy (HP:0100295)3.57363464
24Increased connective tissue (HP:0009025)3.51580587
25Myopathic facies (HP:0002058)3.38376719
26Ulnar deviation of the wrist (HP:0003049)3.31956530
27Abnormality of the umbilical cord (HP:0010881)3.25614860
28Abnormality of the phalanges of the hallux (HP:0010057)3.25475980
29Exercise-induced myalgia (HP:0003738)3.22031967
30Ulnar bowing (HP:0003031)3.19533737
31Rib fusion (HP:0000902)3.17572730
32Abnormality of the distal phalanges of the toes (HP:0010182)3.14439047
33Abnormality of the calcaneus (HP:0008364)3.13793194
34Abnormality of the fetal cardiovascular system (HP:0010948)3.03728814
35Abnormal umbilical cord blood vessels (HP:0011403)3.03728814
36Single umbilical artery (HP:0001195)3.03728814
37Absent phalangeal crease (HP:0006109)3.03232068
38Thin ribs (HP:0000883)2.97519750
39Pterygium (HP:0001059)2.93252056
40Difficulty climbing stairs (HP:0003551)2.91933344
41Bulbar palsy (HP:0001283)2.91638590
42Weak cry (HP:0001612)2.89776178
43Coronal craniosynostosis (HP:0004440)2.87796020
44Cerebral aneurysm (HP:0004944)2.81291422
45Spinal rigidity (HP:0003306)2.81224789
46Alopecia of scalp (HP:0002293)2.80475905
47Asymmetry of the thorax (HP:0001555)2.79805228
48Hyporeflexia of lower limbs (HP:0002600)2.75111341
49Mildly elevated creatine phosphokinase (HP:0008180)2.74100744
50Turricephaly (HP:0000262)2.71700973
51Muscle fiber splitting (HP:0003555)2.69127981
52Difficulty running (HP:0009046)2.67280892
53Exercise-induced muscle cramps (HP:0003710)2.66385100
54Congenital hip dislocation (HP:0001374)2.66381728
55Testicular atrophy (HP:0000029)2.62562028
56Microretrognathia (HP:0000308)2.61207484
57Abnormality of skeletal muscle fiber size (HP:0012084)2.55719770
58Breast hypoplasia (HP:0003187)2.50192101
59Shallow orbits (HP:0000586)2.45989904
60Increased variability in muscle fiber diameter (HP:0003557)2.44288565
61Birth length less than 3rd percentile (HP:0003561)2.44024609
62Short middle phalanx of the 5th finger (HP:0004220)2.40702668
63Concave nail (HP:0001598)2.40576882
64Neck muscle weakness (HP:0000467)2.38446085
65Aplasia/Hypoplasia involving the musculature (HP:0001460)2.37863270
66Abnormal finger flexion creases (HP:0006143)2.35566000
67Hip contracture (HP:0003273)2.34066806
68Generalized amyotrophy (HP:0003700)2.29838474
69EMG: myopathic abnormalities (HP:0003458)2.29071953
70Gowers sign (HP:0003391)2.26076965
71Periauricular skin pits (HP:0100277)2.24831135
72Preauricular pit (HP:0004467)2.24831135
73Aplasia/Hypoplasia of the sacrum (HP:0008517)2.23762232
74Deep philtrum (HP:0002002)2.23743341
75Thin bony cortex (HP:0002753)2.22071430
76Easy fatigability (HP:0003388)2.21360681
77Vertebral fusion (HP:0002948)2.19806439
78Chromosomal breakage induced by crosslinking agents (HP:0003221)2.19376390
79Abnormal hemoglobin (HP:0011902)2.18922941
80Distal lower limb amyotrophy (HP:0008944)2.16978004
81Syringomyelia (HP:0003396)2.15504934
82Spinal cord lesions (HP:0100561)2.15504934
83Vertebral compression fractures (HP:0002953)2.14783586
84Soft skin (HP:0000977)2.13824536
85Wrist flexion contracture (HP:0001239)2.13410860
86Scapular winging (HP:0003691)2.10813203
87Increased number of teeth (HP:0011069)2.09525466
88Generalized muscle weakness (HP:0003324)2.09350860
89Hypoplastic heart (HP:0001961)2.09036973
90Bowed forearm bones (HP:0003956)2.08805854
91Bowing of the arm (HP:0006488)2.08805854
92Chromsome breakage (HP:0040012)2.07784756
93Abnormality of the calf musculature (HP:0001430)2.07322630
94Microglossia (HP:0000171)2.06889556
95Ankle contracture (HP:0006466)2.05550514
96Elbow flexion contracture (HP:0002987)2.05164887
97Down-sloping shoulders (HP:0200021)2.04440961
98Myotonia (HP:0002486)2.04015312
99Short 5th finger (HP:0009237)2.03832642
100Hypoparathyroidism (HP:0000829)2.02638569
101Progressive muscle weakness (HP:0003323)2.02202956
102Cutaneous melanoma (HP:0012056)2.01328699
103Slender build (HP:0001533)2.00954500
104Muscle hypertrophy of the lower extremities (HP:0008968)2.00913375
105Akinesia (HP:0002304)2.00317792
106Cystic hygroma (HP:0000476)2.00055172
107Pili torti (HP:0003777)1.98964542
108Short humerus (HP:0005792)1.96566334
109Aplasia/Hypoplasia of the patella (HP:0006498)1.94725155
110Hypotrichosis (HP:0001006)1.94407263
111Webbed neck (HP:0000465)1.94388135
112Abnormality of the parietal bone (HP:0002696)1.94044247
113Blue sclerae (HP:0000592)1.93741884
114Abnormality of the aortic arch (HP:0012303)1.93622011
115Short thumb (HP:0009778)1.92930489
116Abnormalities of placenta or umbilical cord (HP:0001194)1.92495666
117Proximal placement of thumb (HP:0009623)1.92466592
118Broad distal phalanx of finger (HP:0009836)1.92231382
119Trismus (HP:0000211)1.92137601
120Broad metatarsal (HP:0001783)1.91801096
121Abnormality of the distal phalanx of the thumb (HP:0009617)1.91044157
122Aortic dissection (HP:0002647)1.90166656
123Reduced subcutaneous adipose tissue (HP:0003758)1.88983547
124Increased density of long bones (HP:0006392)1.88692491
125Mesomelia (HP:0003027)1.88612124
126Distal lower limb muscle weakness (HP:0009053)1.87556087
127Short clavicles (HP:0000894)1.87461920
128Fragile skin (HP:0001030)1.86844556
129Unilateral renal agenesis (HP:0000122)1.86572925
130Slender long bone (HP:0003100)1.85174904
131Exostoses (HP:0100777)1.85002438
132Aplasia cutis congenita (HP:0001057)1.84906127
133Spinal cord compression (HP:0002176)1.84740464
134Facial hemangioma (HP:0000329)1.84554205
135Annular pancreas (HP:0001734)1.83477010
136Aplasia/hypoplasia of the humerus (HP:0006507)1.83444858
137Atresia of the external auditory canal (HP:0000413)1.82921367
138Tarsal synostosis (HP:0008368)1.82616574
139Hypoplastic left heart (HP:0004383)1.82153319
140Skin pits (HP:0100276)1.81983061
141Deviation of the thumb (HP:0009603)1.81923251
142J-shaped sella turcica (HP:0002680)1.81840085
143Respiratory insufficiency due to muscle weakness (HP:0002747)1.80221073
144Muscle stiffness (HP:0003552)1.79980151
145Joint stiffness (HP:0001387)1.79933288
146Calf muscle hypertrophy (HP:0008981)1.78379907
147Genu recurvatum (HP:0002816)1.78342266
148Infantile muscular hypotonia (HP:0008947)1.77176519
149Bladder diverticulum (HP:0000015)1.77086562
150Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.76741270
151Hypercortisolism (HP:0001578)1.76596714
152Cervical subluxation (HP:0003308)1.75130601
153Bell-shaped thorax (HP:0001591)1.74621719
154Patellar aplasia (HP:0006443)1.74189166
155Myoglobinuria (HP:0002913)1.73853580
156Hyperparathyroidism (HP:0000843)1.73043070
157Hypoplastic ischia (HP:0003175)1.72852431
158Dysmetric saccades (HP:0000641)1.72499998
159Long toe (HP:0010511)1.72167339
160Selective tooth agenesis (HP:0001592)1.70607358
161Morphological abnormality of the middle ear (HP:0008609)1.70291552
162Abnormality of the 2nd finger (HP:0004100)1.69625625
163Congenital glaucoma (HP:0001087)1.69123818
164Short nail (HP:0001799)1.66969723
165Biconcave vertebral bodies (HP:0004586)1.64923478
166Abnormal number of incisors (HP:0011064)1.64131633
167Smooth philtrum (HP:0000319)1.63174493
168Partial duplication of the phalanx of hand (HP:0009999)1.62358373
169Flat acetabular roof (HP:0003180)1.61733839
170Micronodular cirrhosis (HP:0001413)1.61571181
171Preauricular skin tag (HP:0000384)1.61310482
172Aplasia/Hypoplasia of the clavicles (HP:0006710)1.59676590
173Poikiloderma (HP:0001029)1.59557753
174Renal dysplasia (HP:0000110)1.59254217
175Breast carcinoma (HP:0003002)1.58742352
176Abnormal tarsal ossification (HP:0008369)1.56208670

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR25.00550404
2ICK4.61709928
3MAPK153.39942590
4TRIB33.23735828
5TTN3.12306132
6PDGFRA2.90331827
7MAP3K112.61572548
8OBSCN2.56118746
9BMX2.49260394
10LATS22.46960768
11MAP3K62.42463427
12SMG12.37397452
13IRAK32.34877406
14PINK12.28822715
15PDK22.23173953
16PIM22.17373233
17VRK22.07896318
18MAP3K101.98953607
19MAP3K121.96592108
20MOS1.86143788
21LATS11.84798974
22NME21.78504295
23TESK11.77459057
24TYRO31.71520736
25UHMK11.58665915
26MATK1.58577348
27PHKG11.57814221
28PHKG21.57814221
29MST1R1.56888305
30FGR1.56568037
31TRPM71.54211483
32DYRK1B1.52439902
33PIK3CG1.51607493
34PRKD21.49805291
35AKT31.48983685
36MYLK1.47919428
37PNCK1.43310628
38CDK61.43208359
39PBK1.38440188
40WEE11.32514971
41NEK61.31889668
42SCYL21.27205732
43PAK21.22470663
44MUSK1.21739841
45ERBB31.19974337
46CDK71.19275630
47ILK1.16331101
48CSK1.15764135
49PKN21.12121093
50CDK81.11501512
51RPS6KB21.10637761
52MTOR1.05571675
53TAOK21.05178587
54RPS6KC11.05117651
55RPS6KL11.05117651
56MAPK111.03912078
57CDC42BPA0.98373181
58BRSK10.96709132
59SRPK10.95309769
60TAF10.93526472
61AURKA0.93147474
62RPS6KA60.92866760
63PRKCI0.92431341
64ARAF0.91516987
65TTK0.90540621
66MELK0.87451329
67NME10.87056791
68BRSK20.85833647
69STK160.82482279
70YES10.81906680
71STK30.80063413
72SIK10.77599130
73PAK40.76581912
74AURKB0.75940411
75MAPKAPK30.74647815
76MAP2K30.74630117
77EPHA20.73585778
78DAPK10.72457613
79TRIM280.72074460
80EPHB20.70631096
81ERN10.69911444
82MAP2K20.69406858
83BUB10.69102290
84RPS6KA10.67615753
85PDGFRB0.67569079
86MAPKAPK50.67259819
87DMPK0.66419716
88ATR0.65682384
89RPS6KA20.64528447
90BRD40.64119427
91GSK3A0.63215468
92FGFR10.62537848
93CHEK10.61654359
94PTK20.61069744
95STK380.58935282
96ALK0.58102061
97NEK10.57636027
98DYRK30.57285892
99PIM10.55167216
100RIPK10.54876207
101PDPK10.54813107
102CDK150.54349917
103LIMK10.54205842
104PTK60.54109969
105MAP2K10.53688190
106EEF2K0.53441488
107TSSK60.52834365
108LRRK20.51758097
109ROCK20.51618836
110PAK10.50153195
111MAP3K30.50056304
112CDK11A0.49513333
113NEK20.49451869
114EIF2AK30.48850511
115CDC70.47577133
116CDK180.47406437
117CHEK20.46341187
118CDK90.46274384
119PRKD30.46262520
120TESK20.45751309
121AKT20.45199384
122TAOK10.44273196
123CAMK1G0.44199718
124RPS6KB10.43925048
125PLK10.43869335
126PRKAA10.43706236
127CDK140.43662407
128BRAF0.42308127
129MKNK10.41735919
130MKNK20.40946607
131HIPK20.40914431
132MAP3K80.40320368
133MAPKAPK20.40131442
134CHUK0.37963965
135EIF2AK10.36186500
136PTK2B0.36174254
137RPS6KA40.34423661
138CSNK1A1L0.34285889
139CAMK2G0.33333193
140CDK120.33015237
141ABL20.32922775
142CDK20.32907925
143NEK90.32545612
144RAF10.32253075
145MAPK10.31527973
146MAP3K90.29516772
147INSR0.28156227
148CDK40.28149868
149TLK10.27362397
150MET0.26256147
151MAP3K70.25904557

Predicted pathways (KEGG)

RankGene SetZ-score
1Base excision repair_Homo sapiens_hsa034102.92173571
2Fatty acid biosynthesis_Homo sapiens_hsa000612.84387834
3Hedgehog signaling pathway_Homo sapiens_hsa043402.56312182
4Hippo signaling pathway_Homo sapiens_hsa043902.49484396
5Mismatch repair_Homo sapiens_hsa034302.46872888
6Basal cell carcinoma_Homo sapiens_hsa052172.39215001
7Bladder cancer_Homo sapiens_hsa052192.23569895
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.19363811
9Adherens junction_Homo sapiens_hsa045202.10879606
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.05960440
11Focal adhesion_Homo sapiens_hsa045102.04938348
12mTOR signaling pathway_Homo sapiens_hsa041502.00300407
13Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.98188181
14DNA replication_Homo sapiens_hsa030301.91489298
15Proteoglycans in cancer_Homo sapiens_hsa052051.86608131
16TGF-beta signaling pathway_Homo sapiens_hsa043501.83829731
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.82703466
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.74798610
19Dilated cardiomyopathy_Homo sapiens_hsa054141.69034834
20MicroRNAs in cancer_Homo sapiens_hsa052061.67959280
21ECM-receptor interaction_Homo sapiens_hsa045121.67845674
22Viral myocarditis_Homo sapiens_hsa054161.66872224
23Notch signaling pathway_Homo sapiens_hsa043301.64492968
24Chronic myeloid leukemia_Homo sapiens_hsa052201.59932884
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.56084389
26Arginine and proline metabolism_Homo sapiens_hsa003301.51911097
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.49930936
28Biosynthesis of amino acids_Homo sapiens_hsa012301.48832814
29Circadian rhythm_Homo sapiens_hsa047101.48815136
30RNA polymerase_Homo sapiens_hsa030201.48380779
31p53 signaling pathway_Homo sapiens_hsa041151.46108119
32Pyrimidine metabolism_Homo sapiens_hsa002401.45785546
33Fanconi anemia pathway_Homo sapiens_hsa034601.43687564
34Longevity regulating pathway - mammal_Homo sapiens_hsa042111.43078233
35Tight junction_Homo sapiens_hsa045301.42484868
36Wnt signaling pathway_Homo sapiens_hsa043101.41994203
37Cell cycle_Homo sapiens_hsa041101.39090751
38Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.37218236
39Spliceosome_Homo sapiens_hsa030401.32571335
40RNA transport_Homo sapiens_hsa030131.31449280
41Vitamin B6 metabolism_Homo sapiens_hsa007501.29951358
42Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.28549715
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.28373868
44Shigellosis_Homo sapiens_hsa051311.27954546
45Phenylalanine metabolism_Homo sapiens_hsa003601.27649951
46Small cell lung cancer_Homo sapiens_hsa052221.27207039
47Regulation of actin cytoskeleton_Homo sapiens_hsa048101.27109219
48Central carbon metabolism in cancer_Homo sapiens_hsa052301.21163266
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.15032218
50Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.14897958
51Insulin signaling pathway_Homo sapiens_hsa049101.14660993
52mRNA surveillance pathway_Homo sapiens_hsa030151.14332939
53Nucleotide excision repair_Homo sapiens_hsa034201.12905155
54VEGF signaling pathway_Homo sapiens_hsa043701.12367358
55Selenocompound metabolism_Homo sapiens_hsa004501.08573503
56N-Glycan biosynthesis_Homo sapiens_hsa005101.07768220
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.07068413
58Transcriptional misregulation in cancer_Homo sapiens_hsa052021.03844976
59PI3K-Akt signaling pathway_Homo sapiens_hsa041511.03810736
60Folate biosynthesis_Homo sapiens_hsa007901.02350054
61Sulfur relay system_Homo sapiens_hsa041220.99550755
62Prostate cancer_Homo sapiens_hsa052150.99511955
63Acute myeloid leukemia_Homo sapiens_hsa052210.98590127
64Dorso-ventral axis formation_Homo sapiens_hsa043200.98052279
65Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.97864017
66Gap junction_Homo sapiens_hsa045400.97820118
67Ribosome_Homo sapiens_hsa030100.94343842
68Melanoma_Homo sapiens_hsa052180.92160879
69HTLV-I infection_Homo sapiens_hsa051660.91052054
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.89873833
71HIF-1 signaling pathway_Homo sapiens_hsa040660.89372082
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87873112
73Proteasome_Homo sapiens_hsa030500.86597556
74Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.86046487
75Amoebiasis_Homo sapiens_hsa051460.84599092
76Basal transcription factors_Homo sapiens_hsa030220.83751309
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.82454198
78AMPK signaling pathway_Homo sapiens_hsa041520.82067628
79Pathways in cancer_Homo sapiens_hsa052000.80635103
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.80500786
81Colorectal cancer_Homo sapiens_hsa052100.80213429
82Pentose phosphate pathway_Homo sapiens_hsa000300.77615687
83Lysine degradation_Homo sapiens_hsa003100.77463583
84Purine metabolism_Homo sapiens_hsa002300.76750270
85Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74097606
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72876766
87Glioma_Homo sapiens_hsa052140.72577178
88Thyroid cancer_Homo sapiens_hsa052160.72100170
89Galactose metabolism_Homo sapiens_hsa000520.71895694
90MAPK signaling pathway_Homo sapiens_hsa040100.71427233
91Glucagon signaling pathway_Homo sapiens_hsa049220.70670080
92ErbB signaling pathway_Homo sapiens_hsa040120.69698637
93Fructose and mannose metabolism_Homo sapiens_hsa000510.67856385
94Melanogenesis_Homo sapiens_hsa049160.65631907
95Insulin resistance_Homo sapiens_hsa049310.65156326
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.63353912
97Endometrial cancer_Homo sapiens_hsa052130.62878259
98Viral carcinogenesis_Homo sapiens_hsa052030.62804575
99Pancreatic cancer_Homo sapiens_hsa052120.62633820
100Glycosaminoglycan degradation_Homo sapiens_hsa005310.62187360
101Oocyte meiosis_Homo sapiens_hsa041140.62109930
102GnRH signaling pathway_Homo sapiens_hsa049120.61952787
103Cardiac muscle contraction_Homo sapiens_hsa042600.61822949
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60848661
105Prolactin signaling pathway_Homo sapiens_hsa049170.60135565
106Arginine biosynthesis_Homo sapiens_hsa002200.60124187
107Non-homologous end-joining_Homo sapiens_hsa034500.58555631
108Sulfur metabolism_Homo sapiens_hsa009200.58202622
109Apoptosis_Homo sapiens_hsa042100.57613596
110Sphingolipid metabolism_Homo sapiens_hsa006000.57575851
111One carbon pool by folate_Homo sapiens_hsa006700.56949866
112Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.56512866
113FoxO signaling pathway_Homo sapiens_hsa040680.55932941
114Choline metabolism in cancer_Homo sapiens_hsa052310.55653827
115Starch and sucrose metabolism_Homo sapiens_hsa005000.55443323
116Cysteine and methionine metabolism_Homo sapiens_hsa002700.54059719
117Axon guidance_Homo sapiens_hsa043600.52417903
118Rap1 signaling pathway_Homo sapiens_hsa040150.50345513
119Tyrosine metabolism_Homo sapiens_hsa003500.49683550
120Hepatitis B_Homo sapiens_hsa051610.49219855
121Vibrio cholerae infection_Homo sapiens_hsa051100.48896133
122Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45431433
123Hepatitis C_Homo sapiens_hsa051600.45099592
124Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44538233
125Estrogen signaling pathway_Homo sapiens_hsa049150.44018893
126Salmonella infection_Homo sapiens_hsa051320.43906289
127Protein digestion and absorption_Homo sapiens_hsa049740.43552912
128Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42551180
129Carbon metabolism_Homo sapiens_hsa012000.42358718
130Fatty acid metabolism_Homo sapiens_hsa012120.41567062
131Renal cell carcinoma_Homo sapiens_hsa052110.41545605
132Homologous recombination_Homo sapiens_hsa034400.41108468
133Legionellosis_Homo sapiens_hsa051340.38812965
134Non-small cell lung cancer_Homo sapiens_hsa052230.36663562

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