HOXB5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in lung and gut development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML) and the occurrence of bronchopulmonary sequestration (BPS) and congenital cystic adenomatoid malformation (CCAM) tissue. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1facial nerve structural organization (GO:0021612)7.31433775
2cranial nerve structural organization (GO:0021604)6.35490618
3cranial nerve morphogenesis (GO:0021602)5.81634818
4axon ensheathment in central nervous system (GO:0032291)5.22014085
5central nervous system myelination (GO:0022010)5.22014085
6definitive hemopoiesis (GO:0060216)5.13051621
7regulation of mammary gland epithelial cell proliferation (GO:0033599)5.07172094
8nucleoside diphosphate catabolic process (GO:0009134)4.79278089
9sequestering of actin monomers (GO:0042989)4.75838295
10ribosomal small subunit assembly (GO:0000028)4.75387366
11phospholipid scrambling (GO:0017121)4.73810714
12diaphragm development (GO:0060539)4.66448154
13skeletal muscle organ development (GO:0060538)4.66036626
14enteric nervous system development (GO:0048484)4.58828833
15thyroid gland development (GO:0030878)4.54111253
16neurofilament cytoskeleton organization (GO:0060052)4.48337752
17mesenchymal cell differentiation involved in kidney development (GO:0072161)4.41825355
18mesenchymal cell differentiation involved in renal system development (GO:2001012)4.41825355
19peripheral nervous system neuron development (GO:0048935)4.27774121
20outer ear morphogenesis (GO:0042473)4.22174270
21viral transcription (GO:0019083)4.18848359
22mammary gland epithelial cell differentiation (GO:0060644)4.16269096
23mesenchymal-epithelial cell signaling (GO:0060638)4.12656877
24negative regulation of erythrocyte differentiation (GO:0045647)4.00974247
25embryonic heart tube development (GO:0035050)3.92267202
26neuron fate specification (GO:0048665)3.86789335
27translational termination (GO:0006415)3.85728633
28face development (GO:0060324)3.84221836
29anatomical structure arrangement (GO:0048532)3.84000702
30respiratory tube development (GO:0030323)3.79797659
31mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.69602353
32* anterior/posterior pattern specification (GO:0009952)3.67162171
33detection of temperature stimulus involved in sensory perception (GO:0050961)3.65568579
34detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.65568579
35grooming behavior (GO:0007625)3.62265349
36negative regulation of leukocyte chemotaxis (GO:0002689)3.56373173
37metanephric mesenchyme development (GO:0072075)3.55545542
38* embryonic skeletal system morphogenesis (GO:0048704)3.50937580
39G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.49710565
40cochlea morphogenesis (GO:0090103)3.48612085
41platelet dense granule organization (GO:0060155)3.48047132
42response to interferon-beta (GO:0035456)3.46755502
43respiratory chain complex IV assembly (GO:0008535)3.40645378
44kidney mesenchyme development (GO:0072074)3.40524105
45megakaryocyte development (GO:0035855)3.35187832
46protein retention in ER lumen (GO:0006621)3.32809569
47negative regulation of calcium ion transport into cytosol (GO:0010523)3.31875576
48positive regulation of receptor biosynthetic process (GO:0010870)3.31735935
49SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.31188109
50cotranslational protein targeting to membrane (GO:0006613)3.31181870
51respiratory system process (GO:0003016)3.30709701
52maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.28464326
53protein targeting to ER (GO:0045047)3.26768058
54mesodermal cell differentiation (GO:0048333)3.24485994
55isoprenoid biosynthetic process (GO:0008299)3.24367251
56planar cell polarity pathway involved in neural tube closure (GO:0090179)3.23971224
57outflow tract septum morphogenesis (GO:0003148)3.22676036
58detection of temperature stimulus (GO:0016048)3.20831545
59response to interferon-alpha (GO:0035455)3.20701783
60dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.20661837
61protein localization to endoplasmic reticulum (GO:0070972)3.19525792
62protein neddylation (GO:0045116)3.16506332
63vascular endothelial growth factor signaling pathway (GO:0038084)3.15638975
64viral life cycle (GO:0019058)3.15316860
65terpenoid biosynthetic process (GO:0016114)3.13442575
66chondrocyte proliferation (GO:0035988)3.12527464
67regulation of apoptotic process involved in morphogenesis (GO:1902337)3.12199729
68establishment of protein localization to endoplasmic reticulum (GO:0072599)3.10592475
69positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.10410561
70cellular protein complex disassembly (GO:0043624)3.10088797
71translational elongation (GO:0006414)3.08417771
72negative regulation of viral entry into host cell (GO:0046597)3.07578621
73cell differentiation involved in metanephros development (GO:0072202)3.07121705
74glucocorticoid receptor signaling pathway (GO:0042921)3.06632932
75vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.05688796
76axon extension involved in axon guidance (GO:0048846)3.04602124
77neuron projection extension involved in neuron projection guidance (GO:1902284)3.04602124
78Golgi transport vesicle coating (GO:0048200)3.04222799
79COPI coating of Golgi vesicle (GO:0048205)3.04222799
80cholesterol biosynthetic process (GO:0006695)3.02365095
81proximal/distal pattern formation (GO:0009954)3.02210265
82regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.99454720
83negative regulation of axon extension involved in axon guidance (GO:0048843)2.98717354
84negative regulation of metanephros development (GO:0072217)2.97433161
85regulation of NFAT protein import into nucleus (GO:0051532)2.96045255
86negative regulation of osteoblast proliferation (GO:0033689)2.95031093
87negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.94915235
88negative regulation of catenin import into nucleus (GO:0035414)2.93951476
89glomerulus development (GO:0032835)2.93397090
90axon extension (GO:0048675)2.92644745
91vitamin A metabolic process (GO:0006776)2.91922730
92SMAD protein complex assembly (GO:0007183)2.90271020
93pattern specification involved in kidney development (GO:0061004)2.89206049
94nephron tubule formation (GO:0072079)2.88494101
95cranial nerve development (GO:0021545)2.87971613
96response to water (GO:0009415)2.87382404
97mesenchymal to epithelial transition (GO:0060231)2.87181574
98layer formation in cerebral cortex (GO:0021819)2.87078932
99fucose catabolic process (GO:0019317)2.85490513
100L-fucose metabolic process (GO:0042354)2.85490513
101L-fucose catabolic process (GO:0042355)2.85490513
102short-term memory (GO:0007614)2.83007795
103thrombin receptor signaling pathway (GO:0070493)2.82844666
104* skeletal system morphogenesis (GO:0048705)2.82288103
105renal system development (GO:0072001)2.81136135
106embryonic foregut morphogenesis (GO:0048617)2.80987402
107protein heterotrimerization (GO:0070208)2.79122746
108hematopoietic stem cell differentiation (GO:0060218)2.79008539
109cartilage morphogenesis (GO:0060536)2.78179127
110positive regulation of endothelial cell differentiation (GO:0045603)2.78134541
111mesonephros development (GO:0001823)2.77283368
112negative regulation of dendrite morphogenesis (GO:0050774)2.76555490
113epithelial tube branching involved in lung morphogenesis (GO:0060441)2.75908875
114lung secretory cell differentiation (GO:0061140)2.75512445
115mesonephric epithelium development (GO:0072163)2.75121396
116neural crest cell development (GO:0014032)2.74172399
117aggressive behavior (GO:0002118)2.73952883
118embryonic skeletal system development (GO:0048706)2.73873836
119retinal ganglion cell axon guidance (GO:0031290)2.73481417
120lung-associated mesenchyme development (GO:0060484)2.72228646
121sterol biosynthetic process (GO:0016126)2.71581621
122semaphorin-plexin signaling pathway (GO:0071526)2.70889655
123cell migration in hindbrain (GO:0021535)2.70888294
124regulation of axon extension involved in axon guidance (GO:0048841)2.70607682
125lung morphogenesis (GO:0060425)2.70365696
126morphogenesis of an endothelium (GO:0003159)2.70268298
127endothelial tube morphogenesis (GO:0061154)2.70268298
128protein complex disassembly (GO:0043241)2.69022131
129regulation of early endosome to late endosome transport (GO:2000641)2.68876781
130regulation of pigment cell differentiation (GO:0050932)2.68732134
131basement membrane organization (GO:0071711)2.68468972
132ureteric bud development (GO:0001657)2.68071746
133nerve development (GO:0021675)2.67043415
134neuronal action potential propagation (GO:0019227)2.66355912
135positive regulation of metanephros development (GO:0072216)2.66309451
136metanephros development (GO:0001656)2.65684471
137endocardial cushion development (GO:0003197)2.64992217
138regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.64925423
139macromolecular complex disassembly (GO:0032984)2.63689911
140morphogenesis of an epithelial sheet (GO:0002011)2.63296197
141mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.62982637
142negative regulation of heart rate (GO:0010459)2.60783468
143mesonephric tubule development (GO:0072164)2.59201381
144nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.59135169
145postsynaptic membrane organization (GO:0001941)2.59091239
146positive regulation of odontogenesis (GO:0042482)2.58829944
147barbed-end actin filament capping (GO:0051016)2.58006603
148motor neuron axon guidance (GO:0008045)2.57873480
149negative regulation of cell size (GO:0045792)2.57603601
150lymphangiogenesis (GO:0001946)2.57488120
151regulation of cardioblast differentiation (GO:0051890)2.57445980
152collagen fibril organization (GO:0030199)2.56610143
153mitochondrial calcium ion homeostasis (GO:0051560)2.56113761
154* embryonic organ morphogenesis (GO:0048562)2.55948736
155lymph vessel development (GO:0001945)2.54749281
156mammary gland development (GO:0030879)2.54093146
157regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.53499076
158regulation of heart morphogenesis (GO:2000826)2.53280146
159neuron remodeling (GO:0016322)2.52976400
160regulation of collateral sprouting (GO:0048670)2.52860424
161regulation of glomerulus development (GO:0090192)2.52647275
162negative regulation of norepinephrine secretion (GO:0010700)2.52074813
163actin filament depolymerization (GO:0030042)2.52040474
164regulation of glucose import in response to insulin stimulus (GO:2001273)2.51414531
165negative regulation of axon guidance (GO:1902668)2.51404842
166endothelium development (GO:0003158)2.50913196
167artery morphogenesis (GO:0048844)2.48781588
168protein targeting to plasma membrane (GO:0072661)2.48756017
169embryonic skeletal joint morphogenesis (GO:0060272)2.48410622
170positive regulation of cartilage development (GO:0061036)2.46859150
171somatic stem cell division (GO:0048103)2.46714102
172atrioventricular valve morphogenesis (GO:0003181)2.46162579
173negative regulation of stem cell proliferation (GO:2000647)2.45644933

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.92538111
2CHD7_19251738_ChIP-ChIP_MESCs_Mouse3.81304077
3EED_16625203_ChIP-ChIP_MESCs_Mouse3.53451016
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.50875965
5* EZH2_18974828_ChIP-Seq_MESCs_Mouse3.40435590
6* RNF2_18974828_ChIP-Seq_MESCs_Mouse3.40435590
7* SUZ12_18692474_ChIP-Seq_MEFs_Mouse3.38842362
8* EZH2_27304074_Chip-Seq_ESCs_Mouse3.30806184
9* JARID2_20075857_ChIP-Seq_MESCs_Mouse3.30381894
10PHC1_16625203_ChIP-ChIP_MESCs_Mouse3.24907384
11* BMI1_23680149_ChIP-Seq_NPCS_Mouse3.20609195
12CDX2_19796622_ChIP-Seq_MESCs_Mouse3.04074610
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.96851591
14* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.92947794
15* CDX2_20551321_ChIP-Seq_CACO-2_Human2.89344005
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.84170401
17* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.80090070
18STAT6_21828071_ChIP-Seq_BEAS2B_Human2.71755228
19* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.70590467
20* EZH2_27294783_Chip-Seq_ESCs_Mouse2.51319376
21RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.41014269
22* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.38913662
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.36669579
24* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.35313218
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.33951738
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.33375341
27CBX2_27304074_Chip-Seq_ESCs_Mouse2.23454907
28* TP53_20018659_ChIP-ChIP_R1E_Mouse2.12133381
29* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.04909024
30* KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.04313957
31* KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.04313957
32* KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.04313957
33IKZF1_21737484_ChIP-ChIP_HCT116_Human1.97883247
34RNF2_27304074_Chip-Seq_ESCs_Mouse1.97366330
35* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.91850354
36BP1_19119308_ChIP-ChIP_Hs578T_Human1.90976994
37EGR1_19374776_ChIP-ChIP_THP-1_Human1.88859342
38KDM2B_26808549_Chip-Seq_SUP-B15_Human1.87097725
39KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.85312440
40TP63_19390658_ChIP-ChIP_HaCaT_Human1.84079520
41KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.80536584
42P300_27058665_Chip-Seq_ZR-75-30cells_Human1.75394525
43SCL_19346495_ChIP-Seq_HPC-7_Human1.74389859
44* RNF2_27304074_Chip-Seq_NSC_Mouse1.72938073
45RARG_19884340_ChIP-ChIP_MEFs_Mouse1.72740167
46TP53_22127205_ChIP-Seq_IMR90_Human1.70614687
47UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.70532591
48HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.66507011
49KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.65478096
50* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.63625769
51WT1_19549856_ChIP-ChIP_CCG9911_Human1.63018920
52EZH2_22144423_ChIP-Seq_EOC_Human1.61918465
53GBX2_23144817_ChIP-Seq_PC3_Human1.60590813
54* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.57339141
55RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.57106580
56MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.56997284
57TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.56071841
58* LXR_22292898_ChIP-Seq_THP-1_Human1.55571170
59NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.53952476
60* RING1B_27294783_Chip-Seq_NPCs_Mouse1.49903301
61* TET1_21451524_ChIP-Seq_MESCs_Mouse1.43899478
62* RING1B_27294783_Chip-Seq_ESCs_Mouse1.41101818
63CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.39027578
64WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.38856847
65RBPJ_22232070_ChIP-Seq_NCS_Mouse1.38156987
66DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.38136798
67PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.37760204
68UBF1/2_26484160_Chip-Seq_HMECs_Human1.35292113
69STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.34873559
70KDM2B_26808549_Chip-Seq_JURKAT_Human1.33325751
71* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.31262270
72CLOCK_20551151_ChIP-Seq_293T_Human1.31233951
73EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.29186116
74KDM2B_26808549_Chip-Seq_DND41_Human1.28220586
75ZNF263_19887448_ChIP-Seq_K562_Human1.25315773
76GATA2_21666600_ChIP-Seq_HMVEC_Human1.25001717
77TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24567684
78PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.21495967
79LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.20244474
80EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.18875873
81ERG_21242973_ChIP-ChIP_JURKAT_Human1.17411182
82NFIB_24661679_ChIP-Seq_LUNG_Mouse1.14203335
83* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.13494088
84ESR1_15608294_ChIP-ChIP_MCF-7_Human1.12397130
85TCF7_22412390_ChIP-Seq_EML_Mouse1.12350602
86SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.12147940
87TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.11836814
88TRIM28_21343339_ChIP-Seq_HEK293_Human1.10566759
89ATF3_27146783_Chip-Seq_COLON_Human1.10425924
90TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09600511
91SOX2_20726797_ChIP-Seq_SW620_Human1.09560514
92SOX2_27498859_Chip-Seq_STOMACH_Mouse1.08468526
93TAF15_26573619_Chip-Seq_HEK293_Human1.08153681
94CREB1_26743006_Chip-Seq_LNCaP_Human1.06189026
95MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.05970138
96TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04797883
97ESR2_21235772_ChIP-Seq_MCF-7_Human1.04434342
98SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.04072878
99SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.04072878
100TET1_21490601_ChIP-Seq_MESCs_Mouse1.02516605
101ELK3_25401928_ChIP-Seq_HUVEC_Human1.01720393
102DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00646963
103ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.99876981
104ISL1_27105846_Chip-Seq_CPCs_Mouse0.99357145
105SA1_27219007_Chip-Seq_ERYTHROID_Human0.98668052
106MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.98286353
107DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95193431
108SA1_22415368_ChIP-Seq_MEFs_Mouse0.94574878
109NR3C1_23031785_ChIP-Seq_PC12_Mouse0.93988997
110NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.90751128
111SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89133912
112TCF4_18268006_ChIP-ChIP_LS174T_Human0.87258872
113NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.86676087
114ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.85297343
115ESR1_21235772_ChIP-Seq_MCF-7_Human0.85229083
116SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84497207
117ZNF274_21170338_ChIP-Seq_K562_Hela0.81194696
118KDM2B_26808549_Chip-Seq_K562_Human0.79864198
119* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.79845400
120VDR_22108803_ChIP-Seq_LS180_Human0.79722505
121CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79418262
122ZFP281_18757296_ChIP-ChIP_E14_Mouse0.78106896
123SOX2_18692474_ChIP-Seq_MEFs_Mouse0.77473775
124VDR_24787735_ChIP-Seq_THP-1_Human0.77254629
125* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.76813132
126P300_19829295_ChIP-Seq_ESCs_Human0.76563302
127KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.76114236
128RACK7_27058665_Chip-Seq_MCF-7_Human0.75989647
129BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.75051916
130PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.74825805
131EP300_21415370_ChIP-Seq_HL-1_Mouse0.74759467
132CTCF_27219007_Chip-Seq_ERYTHROID_Human0.74485967
133MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.74331858
134NANOG_20526341_ChIP-Seq_ESCs_Human0.73451898
135ESR1_20079471_ChIP-ChIP_T-47D_Human0.72917411
136ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.72028749
137EOMES_21245162_ChIP-Seq_HESCs_Human0.71932661
138FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.70795300
139* ESET_19884257_ChIP-Seq_ESCs_Mouse0.70287383
140SA1_27219007_Chip-Seq_Bcells_Human0.70248706
141* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.70134970
142PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.69937159
143SMAD_19615063_ChIP-ChIP_OVARY_Human0.69902532
144EGR1_19032775_ChIP-ChIP_M12_Human0.69021290
145CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.68975525
146CTCF_27219007_Chip-Seq_Bcells_Human0.67628424
147NRF2_20460467_ChIP-Seq_MEFs_Mouse0.66884914
148NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.66884914
149RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.66763358

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.58228226
2MP0002249_abnormal_larynx_morphology3.39147563
3MP0005409_darkened_coat_color3.37098714
4MP0009379_abnormal_foot_pigmentation3.29371282
5MP0008260_abnormal_autophagy3.19511542
6MP0002735_abnormal_chemical_nociception2.92894274
7MP0003315_abnormal_perineum_morphology2.76372570
8MP0001968_abnormal_touch/_nociception2.74934840
9MP0001879_abnormal_lymphatic_vessel2.67791930
10MP0002736_abnormal_nociception_after2.64971208
11MP0010368_abnormal_lymphatic_system2.64138199
12MP0005167_abnormal_blood-brain_barrier2.63986173
13MP0003136_yellow_coat_color2.59358499
14MP0000534_abnormal_ureter_morphology2.58354839
15MP0003705_abnormal_hypodermis_morpholog2.49154449
16MP0005257_abnormal_intraocular_pressure2.46748387
17MP0004782_abnormal_surfactant_physiolog2.45852610
18MP0003385_abnormal_body_wall2.44740115
19MP0003942_abnormal_urinary_system2.43630895
20MP0003011_delayed_dark_adaptation2.42901660
21MP0004270_analgesia2.40332128
22MP0001986_abnormal_taste_sensitivity2.26315523
23MP0005623_abnormal_meninges_morphology2.20261802
24MP0003279_aneurysm2.17788055
25MP0001348_abnormal_lacrimal_gland2.14374668
26MP0002938_white_spotting1.98535387
27MP0009053_abnormal_anal_canal1.98505973
28MP0005503_abnormal_tendon_morphology1.96594845
29MP0002877_abnormal_melanocyte_morpholog1.93938211
30MP0001970_abnormal_pain_threshold1.93909929
31MP0002751_abnormal_autonomic_nervous1.90783150
32MP0002184_abnormal_innervation1.90484801
33MP0004142_abnormal_muscle_tone1.88162663
34MP0000955_abnormal_spinal_cord1.86777436
35MP0000733_abnormal_muscle_development1.86399443
36MP0000681_abnormal_thyroid_gland1.83619625
37MP0002282_abnormal_trachea_morphology1.83106241
38MP0002733_abnormal_thermal_nociception1.80648623
39MP0000013_abnormal_adipose_tissue1.80595512
40MP0001664_abnormal_digestion1.76243041
41* MP0009250_abnormal_appendicular_skeleto1.72665561
42MP0002734_abnormal_mechanical_nocicepti1.70575746
43MP0005083_abnormal_biliary_tract1.69825900
44MP0000920_abnormal_myelination1.65140306
45MP0001188_hyperpigmentation1.65054009
46MP0000678_abnormal_parathyroid_gland1.62631600
47MP0005670_abnormal_white_adipose1.56793511
48MP0002932_abnormal_joint_morphology1.56363279
49MP0009278_abnormal_bone_marrow1.54866167
50MP0003938_abnormal_ear_development1.53652142
51MP0010030_abnormal_orbit_morphology1.50169341
52MP0004134_abnormal_chest_morphology1.49261947
53MP0005076_abnormal_cell_differentiation1.48700964
54MP0001270_distended_abdomen1.43610246
55MP0000049_abnormal_middle_ear1.41377410
56MP0000003_abnormal_adipose_tissue1.41369541
57MP0000465_gastrointestinal_hemorrhage1.35411691
58MP0004272_abnormal_basement_membrane1.31483672
59MP0003119_abnormal_digestive_system1.31461838
60* MP0002752_abnormal_somatic_nervous1.30286983
61MP0002177_abnormal_outer_ear1.29121134
62MP0003566_abnormal_cell_adhesion1.28106073
63MP0001299_abnormal_eye_distance/1.27501883
64MP0002822_catalepsy1.25224607
65MP0000516_abnormal_urinary_system1.24336161
66MP0005367_renal/urinary_system_phenotyp1.24336161
67MP0001958_emphysema1.22486604
68MP0006276_abnormal_autonomic_nervous1.22077401
69MP0008004_abnormal_stomach_pH1.21349603
70MP0002108_abnormal_muscle_morphology1.20357800
71MP0000762_abnormal_tongue_morphology1.18809174
72MP0005275_abnormal_skin_tensile1.17959309
73MP0004858_abnormal_nervous_system1.17630915
74MP0010352_gastrointestinal_tract_polyps1.17191511
75MP0003880_abnormal_central_pattern1.16098097
76MP0005084_abnormal_gallbladder_morpholo1.13297120
77MP0003283_abnormal_digestive_organ1.13219424
78MP0004742_abnormal_vestibular_system1.08584226
79MP0003724_increased_susceptibility_to1.06891094
80MP0003935_abnormal_craniofacial_develop1.06768433
81MP0009384_cardiac_valve_regurgitation1.05208393
82MP0000759_abnormal_skeletal_muscle1.02364811
83MP0000372_irregular_coat_pigmentation1.01808489
84MP0000428_abnormal_craniofacial_morphol1.00360411
85MP0002116_abnormal_craniofacial_bone1.00281680
86MP0003091_abnormal_cell_migration0.99972860
87MP0002067_abnormal_sensory_capabilities0.99938537
88MP0002896_abnormal_bone_mineralization0.96927838
89MP0004185_abnormal_adipocyte_glucose0.96807223
90MP0000477_abnormal_intestine_morphology0.96166121
91MP0002925_abnormal_cardiovascular_devel0.94419189
92MP0002882_abnormal_neuron_morphology0.94295853
93MP0005408_hypopigmentation0.94179900
94MP0004264_abnormal_extraembryonic_tissu0.92383265
95MP0002085_abnormal_embryonic_tissue0.91641488
96MP0003755_abnormal_palate_morphology0.91499352
97MP0002089_abnormal_postnatal_growth/wei0.90340481
98MP0000751_myopathy0.89894572
99* MP0002114_abnormal_axial_skeleton0.89478635
100MP0002081_perinatal_lethality0.89268704
101MP0000432_abnormal_head_morphology0.89089664
102MP0005375_adipose_tissue_phenotype0.88903956
103MP0000767_abnormal_smooth_muscle0.88503124
104MP0002113_abnormal_skeleton_development0.88096446
105MP0001849_ear_inflammation0.87627712
106MP0000163_abnormal_cartilage_morphology0.86461439
107MP0002272_abnormal_nervous_system0.84895103
108MP0000778_abnormal_nervous_system0.84877598
109MP0001943_abnormal_respiration0.84329622
110MP0001177_atelectasis0.83012302
111MP0001905_abnormal_dopamine_level0.82994473
112MP0005508_abnormal_skeleton_morphology0.82914580
113MP0002095_abnormal_skin_pigmentation0.82848500
114MP0005171_absent_coat_pigmentation0.81517771
115MP0005595_abnormal_vascular_smooth0.81153450
116MP0003943_abnormal_hepatobiliary_system0.80472029
117MP0002148_abnormal_hypersensitivity_rea0.79988111
118MP0000462_abnormal_digestive_system0.79921161
119MP0003861_abnormal_nervous_system0.79653295
120MP0010307_abnormal_tumor_latency0.77381058
121MP0004808_abnormal_hematopoietic_stem0.76701382
122MP0002127_abnormal_cardiovascular_syste0.76217417
123MP0003937_abnormal_limbs/digits/tail_de0.75937735
124MP0001340_abnormal_eyelid_morphology0.75569178
125MP0003122_maternal_imprinting0.74221776
126MP0002084_abnormal_developmental_patter0.74152600
127MP0001614_abnormal_blood_vessel0.74076071
128MP0002086_abnormal_extraembryonic_tissu0.74032444
129MP0005645_abnormal_hypothalamus_physiol0.73970643
130MP0000749_muscle_degeneration0.73774713
131MP0003634_abnormal_glial_cell0.73604723
132MP0002132_abnormal_respiratory_system0.72664863
133MP0000566_synostosis0.72182012
134MP0005464_abnormal_platelet_physiology0.72038829
135MP0009780_abnormal_chondrocyte_physiolo0.71039164
136MP0001730_embryonic_growth_arrest0.70331752
137MP0003866_abnormal_defecation0.70139541
138MP0000467_abnormal_esophagus_morphology0.69961992
139MP0005187_abnormal_penis_morphology0.69859430
140MP0000015_abnormal_ear_pigmentation0.69384511
141MP0008874_decreased_physiological_sensi0.69046916
142MP0002876_abnormal_thyroid_physiology0.66987347
143MP0000537_abnormal_urethra_morphology0.64832034
144MP0002277_abnormal_respiratory_mucosa0.62973308
145MP0000639_abnormal_adrenal_gland0.62007778
146MP0003567_abnormal_fetal_cardiomyocyte0.61623622
147MP0004883_abnormal_blood_vessel0.60482912
148MP0002064_seizures0.59847904
149MP0004145_abnormal_muscle_electrophysio0.58568945
150MP0003115_abnormal_respiratory_system0.57942067
151MP0005023_abnormal_wound_healing0.56293868
152MP0005197_abnormal_uvea_morphology0.56138811
153MP0000538_abnormal_urinary_bladder0.55443187
154MP0001346_abnormal_lacrimal_gland0.55132456
155MP0005423_abnormal_somatic_nervous0.54899093

Predicted human phenotypes

RankGene SetZ-score
1Septate vagina (HP:0001153)6.18902314
2Myokymia (HP:0002411)4.93469728
3Aplasia/Hypoplasia of the sacrum (HP:0008517)4.69078919
4Premature rupture of membranes (HP:0001788)4.56899948
5Bicornuate uterus (HP:0000813)4.20505656
6Protrusio acetabuli (HP:0003179)4.09286516
7Metaphyseal dysplasia (HP:0100255)4.08509319
8Spinal cord lesions (HP:0100561)3.81021738
9Syringomyelia (HP:0003396)3.81021738
10Abnormality of the fetal cardiovascular system (HP:0010948)3.69848445
11Abnormal umbilical cord blood vessels (HP:0011403)3.69848445
12Single umbilical artery (HP:0001195)3.69848445
13Nonprogressive disorder (HP:0003680)3.63210626
14Facial shape deformation (HP:0011334)3.57240749
15Potter facies (HP:0002009)3.57240749
16Abnormality of the phalanges of the 2nd finger (HP:0009541)3.42810093
17Arterial tortuosity (HP:0005116)3.38754497
18Aortic dissection (HP:0002647)3.36318012
19Vascular tortuosity (HP:0004948)3.29175918
20Rectal fistula (HP:0100590)3.28430071
21Rectovaginal fistula (HP:0000143)3.28430071
22Cerebral aneurysm (HP:0004944)3.28391116
23Abnormality of magnesium homeostasis (HP:0004921)3.17269780
24Vaginal fistula (HP:0004320)3.10611825
25Distal upper limb amyotrophy (HP:0007149)3.10315949
26Upper limb amyotrophy (HP:0009129)3.10315949
27Follicular hyperkeratosis (HP:0007502)3.05724877
28Spinal rigidity (HP:0003306)3.03776931
29Intestinal fistula (HP:0100819)3.02624525
30Abnormality of the 2nd finger (HP:0004100)3.02061108
31Stridor (HP:0010307)2.97430846
32Aortic aneurysm (HP:0004942)2.96143308
33Mildly elevated creatine phosphokinase (HP:0008180)2.95548304
34Broad face (HP:0000283)2.95271584
35Annular pancreas (HP:0001734)2.91102050
36Bladder diverticulum (HP:0000015)2.89981226
37Ankle contracture (HP:0006466)2.89144268
38Germ cell neoplasia (HP:0100728)2.88230724
39Myotonia (HP:0002486)2.86178388
40Abnormality of dentin (HP:0010299)2.85894393
41Mesangial abnormality (HP:0001966)2.79942766
42Muscle stiffness (HP:0003552)2.78466509
43Hypoplastic left heart (HP:0004383)2.78269931
44Pheochromocytoma (HP:0002666)2.77249182
45Hyperacusis (HP:0010780)2.76047595
46Absent rod-and cone-mediated responses on ERG (HP:0007688)2.75000931
47Abnormality of the umbilical cord (HP:0010881)2.74601977
48White forelock (HP:0002211)2.73582268
49Bradycardia (HP:0001662)2.70774174
50Genu recurvatum (HP:0002816)2.68883003
51Cerebral hemorrhage (HP:0001342)2.66266016
52Distal lower limb amyotrophy (HP:0008944)2.65897127
53Popliteal pterygium (HP:0009756)2.63151873
54Vacuolated lymphocytes (HP:0001922)2.61703326
55Ulnar claw (HP:0001178)2.59818875
56Soft skin (HP:0000977)2.59075193
57Hypomagnesemia (HP:0002917)2.57207801
58Hypoventilation (HP:0002791)2.56162332
59Pulmonary artery stenosis (HP:0004415)2.55891552
60Weak cry (HP:0001612)2.55684228
61Obstructive sleep apnea (HP:0002870)2.54984874
62Renal dysplasia (HP:0000110)2.54688475
63Patchy hypopigmentation of hair (HP:0011365)2.53436443
64Lower limb amyotrophy (HP:0007210)2.53148325
65Renal hypoplasia (HP:0000089)2.50823304
66Wormian bones (HP:0002645)2.49817274
67Abnormality of the vocal cords (HP:0008777)2.49408757
68Neuroendocrine neoplasm (HP:0100634)2.48329578
69Abnormality of the distal phalanx of the thumb (HP:0009617)2.47807667
70Shallow orbits (HP:0000586)2.43925583
71Asymmetry of the thorax (HP:0001555)2.41942713
72Disproportionate tall stature (HP:0001519)2.38294428
73Broad metatarsal (HP:0001783)2.32942888
74Sensory axonal neuropathy (HP:0003390)2.32152015
75Neonatal short-limb short stature (HP:0008921)2.30811622
76Renal Fanconi syndrome (HP:0001994)2.30118832
77Type 1 muscle fiber predominance (HP:0003803)2.28999447
78Abnormality of the phalanges of the hallux (HP:0010057)2.27928746
79Abnormality of the parietal bone (HP:0002696)2.26873086
80Partial duplication of thumb phalanx (HP:0009944)2.26473760
81Elbow flexion contracture (HP:0002987)2.25890964
82Termporal pattern (HP:0011008)2.22113458
83Insidious onset (HP:0003587)2.22113458
84Shawl scrotum (HP:0000049)2.21103345
85Atrophic scars (HP:0001075)2.19892422
86Joint laxity (HP:0001388)2.19670732
87Overgrowth (HP:0001548)2.19279528
88Urethral obstruction (HP:0000796)2.19208417
89Limb dystonia (HP:0002451)2.17257105
90Poor suck (HP:0002033)2.17040108
91Asplenia (HP:0001746)2.14516325
92Partial duplication of the phalanx of hand (HP:0009999)2.14335065
93Impaired platelet aggregation (HP:0003540)2.14321625
94Abnormal platelet function (HP:0011869)2.14321625
95Ulnar bowing (HP:0003031)2.14008740
96Retinal dysplasia (HP:0007973)2.13263389
97Mitral valve prolapse (HP:0001634)2.13066549
98Aplasia/Hypoplasia of the spleen (HP:0010451)2.12401586
99Abnormal lung lobation (HP:0002101)2.10625597
100Abnormality of the axillary hair (HP:0100134)2.10172069
101Abnormality of secondary sexual hair (HP:0009888)2.10172069
102Neoplasm of the heart (HP:0100544)2.09672453
103Bifid scrotum (HP:0000048)2.08271274
104Long toe (HP:0010511)2.07936841
105Abnormality of cells of the erythroid lineage (HP:0012130)2.07824531
106Hand muscle atrophy (HP:0009130)2.07742933
107Bowel diverticulosis (HP:0005222)2.06024132
108Nonimmune hydrops fetalis (HP:0001790)2.05730611
109Hypoplastic heart (HP:0001961)2.05317934
110Hyperparathyroidism (HP:0000843)2.05166084
111Down-sloping shoulders (HP:0200021)2.05144495
112Camptodactyly of toe (HP:0001836)2.05143721
113Hypothermia (HP:0002045)2.04938645
114Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.01955820
115Increased hepatocellular lipid droplets (HP:0006565)2.01136972
116Cervical subluxation (HP:0003308)2.00330508
117Keratoconus (HP:0000563)1.98941191
118Increased corneal curvature (HP:0100692)1.98941191
119Hydroureter (HP:0000072)1.96432682
120Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.95766283
121Neonatal respiratory distress (HP:0002643)1.93526709
122Short clavicles (HP:0000894)1.93290013
123Atelectasis (HP:0100750)1.92994176
124Segmental peripheral demyelination/remyelination (HP:0003481)1.92948124
125Renal duplication (HP:0000075)1.92667990
126Achilles tendon contracture (HP:0001771)1.92068871
127Long eyelashes (HP:0000527)1.91572081
128Hyperextensible skin (HP:0000974)1.91541053
129Blue sclerae (HP:0000592)1.91161378
130Abnormality of the aortic arch (HP:0012303)1.90436867
131Hallux valgus (HP:0001822)1.89926314
132Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.89464765
133Proximal placement of thumb (HP:0009623)1.89292482
134Aneurysm (HP:0002617)1.89017607
135Slender build (HP:0001533)1.88950530
136Short phalanx of the thumb (HP:0009660)1.88830076
137Deviation of the hallux (HP:0010051)1.88790482
138Aplasia/Hypoplasia of the clavicles (HP:0006710)1.87374845
139Lipid accumulation in hepatocytes (HP:0006561)1.86761965
140Supranuclear gaze palsy (HP:0000605)1.86320760
141Craniofacial hyperostosis (HP:0004493)1.86120014
142Short nail (HP:0001799)1.83027260
143Morphological abnormality of the middle ear (HP:0008609)1.82075278
144Intestinal atresia (HP:0011100)1.81796472
145Deviation of the thumb (HP:0009603)1.81510623
146Abnormality of the distal phalanges of the toes (HP:0010182)1.81432690
147Neoplasm of the peripheral nervous system (HP:0100007)1.81076277
148Midline defect of the nose (HP:0004122)1.80121032
149Short 4th metacarpal (HP:0010044)1.79488601
150Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.79488601
151Thin ribs (HP:0000883)1.79439559
152Lower limb asymmetry (HP:0100559)1.78967443
153Spondylolisthesis (HP:0003302)1.78704812
154Abnormal hair whorl (HP:0010721)1.78382426
155Protruding ear (HP:0000411)1.78072802
156Dilatation of the ascending aorta (HP:0005111)1.76613246
157Thrombocytosis (HP:0001894)1.75776747
158Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.75301672
159Thin bony cortex (HP:0002753)1.75206581
160Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.74751403
161Sacral dimple (HP:0000960)1.74512600
162Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.72531467
163Buphthalmos (HP:0000557)1.72185227
164Abnormality of the anterior chamber (HP:0000593)1.71919950
165Abnormality of the pulmonary veins (HP:0011718)1.70811050
166Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.70608346
167Degeneration of the lateral corticospinal tracts (HP:0002314)1.70608346
168Arnold-Chiari malformation (HP:0002308)1.68917717
169Abnormality of the 4th metacarpal (HP:0010012)1.67550370
170Increased variability in muscle fiber diameter (HP:0003557)1.67211463
171Stenosis of the external auditory canal (HP:0000402)1.66932718
172Focal segmental glomerulosclerosis (HP:0000097)1.66410881
173Short middle phalanx of the 5th finger (HP:0004220)1.66380156
174Absent frontal sinuses (HP:0002688)1.65661565
175Fragile skin (HP:0001030)1.65578810
176Mitral regurgitation (HP:0001653)1.65397330
177Macroorchidism (HP:0000053)1.65172015
178Hammertoe (HP:0001765)1.65001631
179Wide anterior fontanel (HP:0000260)1.64836898
180Abnormal number of incisors (HP:0011064)1.64772391
181Prolonged bleeding time (HP:0003010)1.64574373
182Calcaneovalgus deformity (HP:0001848)1.64089629
183Abnormal delivery (HP:0001787)1.64041265
184High anterior hairline (HP:0009890)1.63824135
185Dislocated radial head (HP:0003083)1.62919322
186Elfin facies (HP:0004428)1.62757059
187Glomerulosclerosis (HP:0000096)1.62314339
188Action tremor (HP:0002345)1.62122837
189Mesomelia (HP:0003027)1.61571156

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.19049353
2TRIB34.10224296
3MST1R3.74672961
4GRK53.50241617
5MUSK3.49501262
6EPHA23.20253195
7LIMK13.19183998
8TIE13.15273824
9CASK3.08576069
10MAP3K122.98665676
11SIK12.92036711
12CLK12.77103540
13TGFBR12.76701961
14PNCK2.62802294
15MYLK2.60870925
16CDK122.53507698
17TGFBR22.51010213
18PTK22.32880165
19ICK2.24219704
20PDGFRA2.22366025
21RIPK12.21472463
22STK392.09853061
23KDR2.02977533
24EPHB11.95346915
25TESK21.70756671
26CSNK1A1L1.69929099
27CDK81.65227295
28OXSR11.65080094
29CSNK1G31.64999928
30PRKD21.62598282
31NME21.58533657
32EPHB21.56062799
33CSNK1G11.53912682
34YES11.53720758
35EEF2K1.50885703
36BLK1.50138592
37CDK191.48424129
38CAMK1G1.40953729
39DDR21.39344705
40CAMK2B1.37161195
41MAPK131.35420965
42SCYL21.33457582
43BMPR1B1.32956459
44MAP3K61.32243061
45IRAK31.31110176
46MINK11.28345275
47CAMK2G1.28239941
48MTOR1.26874823
49PHKG11.23787973
50PHKG21.23787973
51PAK41.21245597
52UHMK11.19974289
53WNK41.18817446
54TESK11.18334498
55CDK91.15781385
56FER1.14985952
57CAMK2D1.13207345
58PRKD31.11714703
59PRKG21.11559249
60RPS6KB21.09958545
61WNK11.09631373
62PTK2B1.07647607
63ARAF1.06689294
64FLT31.04210772
65LATS11.03903344
66CAMKK21.03274670
67ILK1.00998819
68MAPKAPK50.98607350
69ADRBK20.97324825
70MET0.97284300
71MKNK10.95907469
72CSNK1G20.86009836
73MAP3K100.85170169
74PKN20.84980399
75PLK40.82446245
76BCR0.81663222
77SMG10.81449034
78ROCK20.80866415
79PKN10.80755595
80ERBB30.80586855
81PAK20.80055356
82PIM20.79479499
83AKT30.77828838
84RET0.77528848
85MAP3K10.77337107
86STK380.77130717
87NTRK10.76721144
88KSR20.76121271
89MAP3K80.76046459
90TRPM70.75322171
91IRAK20.75093889
92ADRBK10.74860646
93DYRK20.74389344
94SGK4940.71080093
95SGK2230.71080093
96CDC42BPA0.71025356
97MATK0.70091088
98SIK30.69745619
99CHEK20.69290662
100MAP2K70.67548813
101RPS6KA20.67439593
102NEK20.66742724
103MAPKAPK30.66641326
104MKNK20.66630182
105RIPK40.66222974
106PTK60.62777855
107AKT20.61557347
108CDK11A0.61265663
109EPHA30.60116353
110GRK10.59122462
111DAPK30.58890182
112PRKD10.58229002
113NTRK30.58144941
114PDGFRB0.58128453
115BCKDK0.58111769
116SIK20.56086701
117LMTK20.55687430
118LRRK20.55673565
119CDK180.54954949
120GRK70.54307534
121PAK10.53827010
122BRD40.53748274
123MAP2K30.53680116
124KSR10.53448925
125ABL20.53108003
126CDK150.52982435
127PRKCH0.52979386
128MAP3K70.52593232
129IRAK10.52217555
130LATS20.52165696
131DYRK1B0.51299302
132TTN0.51217569
133ERN10.50775604
134PLK20.50648450
135CDK70.49623136
136CDK140.48486612
137STK40.48218911
138MOS0.47990996
139MAP2K10.47120064
140MAPK120.47009132
141CHEK10.46257369
142ERBB40.45889581
143MAP2K20.45195427
144MAPK40.45153075
145CDK30.44313612
146MELK0.43472139
147TNIK0.42305113
148MARK20.42241468
149ROCK10.40084003
150GSK3A0.39790013
151CAMK2A0.39655173
152CSNK1E0.38416542
153TBK10.37563304
154PRKCD0.35720301
155PRPF4B0.35587523
156PRKCE0.34854934
157MAP2K40.34581049
158IRAK40.34283327
159PRKAA10.33188728
160INSRR0.32376093
161MAP3K110.32362337
162MAPK80.32355741
163RPS6KC10.30108018

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.36025810
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.94344612
3Steroid biosynthesis_Homo sapiens_hsa001003.06246670
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.95819279
5Oxidative phosphorylation_Homo sapiens_hsa001902.82700748
6Parkinsons disease_Homo sapiens_hsa050122.74790805
7Fatty acid elongation_Homo sapiens_hsa000622.73412019
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.62175029
9Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.43432318
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.22475845
11Chronic myeloid leukemia_Homo sapiens_hsa052202.22029985
12Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.19774648
13Sulfur metabolism_Homo sapiens_hsa009202.16082779
14Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.15375178
15Protein export_Homo sapiens_hsa030602.04522811
16Focal adhesion_Homo sapiens_hsa045101.98050378
17Bladder cancer_Homo sapiens_hsa052191.93478107
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.90204427
19Arachidonic acid metabolism_Homo sapiens_hsa005901.89662966
20Ether lipid metabolism_Homo sapiens_hsa005651.88873148
21Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.88645009
22Regulation of autophagy_Homo sapiens_hsa041401.88255573
23SNARE interactions in vesicular transport_Homo sapiens_hsa041301.84414374
24Alzheimers disease_Homo sapiens_hsa050101.76515986
25Pancreatic cancer_Homo sapiens_hsa052121.70019024
26Synaptic vesicle cycle_Homo sapiens_hsa047211.66724072
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.52669494
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.50794146
29Proteoglycans in cancer_Homo sapiens_hsa052051.50166642
30Endometrial cancer_Homo sapiens_hsa052131.40331873
31Glioma_Homo sapiens_hsa052141.39896069
32Protein digestion and absorption_Homo sapiens_hsa049741.39589325
33Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.38605086
34Axon guidance_Homo sapiens_hsa043601.37739463
35ErbB signaling pathway_Homo sapiens_hsa040121.37737546
36Notch signaling pathway_Homo sapiens_hsa043301.36210381
37Choline metabolism in cancer_Homo sapiens_hsa052311.34754940
38Huntingtons disease_Homo sapiens_hsa050161.34655465
39Amoebiasis_Homo sapiens_hsa051461.33601642
40Colorectal cancer_Homo sapiens_hsa052101.33052987
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.31535879
42Melanoma_Homo sapiens_hsa052181.30597703
43Cyanoamino acid metabolism_Homo sapiens_hsa004601.28302227
44Small cell lung cancer_Homo sapiens_hsa052221.28265369
45Adherens junction_Homo sapiens_hsa045201.27449476
46MicroRNAs in cancer_Homo sapiens_hsa052061.20904826
47Non-small cell lung cancer_Homo sapiens_hsa052231.20540199
48Wnt signaling pathway_Homo sapiens_hsa043101.17104276
49Gap junction_Homo sapiens_hsa045401.15344238
50Cocaine addiction_Homo sapiens_hsa050301.15053646
51Estrogen signaling pathway_Homo sapiens_hsa049151.12400874
52Primary bile acid biosynthesis_Homo sapiens_hsa001201.10788931
53Vibrio cholerae infection_Homo sapiens_hsa051101.10503079
54VEGF signaling pathway_Homo sapiens_hsa043701.10004883
55Central carbon metabolism in cancer_Homo sapiens_hsa052301.09553559
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.08511734
57Linoleic acid metabolism_Homo sapiens_hsa005911.07367918
58Phospholipase D signaling pathway_Homo sapiens_hsa040721.07183369
59Thyroid cancer_Homo sapiens_hsa052161.06230555
60Rheumatoid arthritis_Homo sapiens_hsa053231.06124631
61TGF-beta signaling pathway_Homo sapiens_hsa043501.06043410
62Thyroid hormone signaling pathway_Homo sapiens_hsa049191.05101279
63Steroid hormone biosynthesis_Homo sapiens_hsa001401.03818868
64AMPK signaling pathway_Homo sapiens_hsa041521.03758679
65Longevity regulating pathway - mammal_Homo sapiens_hsa042111.02913954
66Salmonella infection_Homo sapiens_hsa051321.02714504
67Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.02612868
68Prostate cancer_Homo sapiens_hsa052150.98573045
69Acute myeloid leukemia_Homo sapiens_hsa052210.96702327
70Renal cell carcinoma_Homo sapiens_hsa052110.95305509
71Prolactin signaling pathway_Homo sapiens_hsa049170.95122918
72Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91526847
73Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.90096676
74Hedgehog signaling pathway_Homo sapiens_hsa043400.87713104
75Platelet activation_Homo sapiens_hsa046110.87436810
76Collecting duct acid secretion_Homo sapiens_hsa049660.86937211
77Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.86405628
78Endocytosis_Homo sapiens_hsa041440.85201083
79Rap1 signaling pathway_Homo sapiens_hsa040150.83992986
80Dopaminergic synapse_Homo sapiens_hsa047280.82547523
81mRNA surveillance pathway_Homo sapiens_hsa030150.81978983
82mTOR signaling pathway_Homo sapiens_hsa041500.80887519
83Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.80520087
842-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.78910127
85Tight junction_Homo sapiens_hsa045300.78062802
86Ovarian steroidogenesis_Homo sapiens_hsa049130.77943785
87Dorso-ventral axis formation_Homo sapiens_hsa043200.77661373
88Insulin signaling pathway_Homo sapiens_hsa049100.76748746
89Cardiac muscle contraction_Homo sapiens_hsa042600.76691301
90Melanogenesis_Homo sapiens_hsa049160.76412763
91Vitamin digestion and absorption_Homo sapiens_hsa049770.75515922
92PI3K-Akt signaling pathway_Homo sapiens_hsa041510.74913007
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.74315279
94Other glycan degradation_Homo sapiens_hsa005110.73642322
95cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70698855
96GnRH signaling pathway_Homo sapiens_hsa049120.70533726
97Ras signaling pathway_Homo sapiens_hsa040140.68816866
98Dilated cardiomyopathy_Homo sapiens_hsa054140.68729746
99Lysine degradation_Homo sapiens_hsa003100.68101099
100Pathways in cancer_Homo sapiens_hsa052000.66271613
101Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65745367
102Neurotrophin signaling pathway_Homo sapiens_hsa047220.65713398
103Pertussis_Homo sapiens_hsa051330.65681063
104Cholinergic synapse_Homo sapiens_hsa047250.64687284
105Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64167973
106Shigellosis_Homo sapiens_hsa051310.63163906
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.62200734
108Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62015760
109Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.61895672
110Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61669399
111Type II diabetes mellitus_Homo sapiens_hsa049300.61491962
112Inositol phosphate metabolism_Homo sapiens_hsa005620.61220236
113Sulfur relay system_Homo sapiens_hsa041220.60661597
114Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60147116
115Serotonergic synapse_Homo sapiens_hsa047260.59994296
116ECM-receptor interaction_Homo sapiens_hsa045120.59868507
117Leukocyte transendothelial migration_Homo sapiens_hsa046700.58922163
118Maturity onset diabetes of the young_Homo sapiens_hsa049500.58828169
119Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.58091901
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56529335
121Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55254687
122N-Glycan biosynthesis_Homo sapiens_hsa005100.54221497
123AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53790140
124Glycosaminoglycan degradation_Homo sapiens_hsa005310.53746474
125Basal cell carcinoma_Homo sapiens_hsa052170.53429775
126Taste transduction_Homo sapiens_hsa047420.53152093
127Phagosome_Homo sapiens_hsa041450.52884442
128Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52740835
129Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52716172
130Retinol metabolism_Homo sapiens_hsa008300.51679920
131Thyroid hormone synthesis_Homo sapiens_hsa049180.50408545
132Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50317508
133Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50214619
134Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49460366
135Peroxisome_Homo sapiens_hsa041460.48830094
136Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48763422
137Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48761960
138MAPK signaling pathway_Homo sapiens_hsa040100.48609643
139Olfactory transduction_Homo sapiens_hsa047400.48398042
140Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48130847
141Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47989291
142Long-term potentiation_Homo sapiens_hsa047200.47602720
143Complement and coagulation cascades_Homo sapiens_hsa046100.47250583
144Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47172379
145Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46628559
146Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46363795
147Bile secretion_Homo sapiens_hsa049760.46198086
148Salivary secretion_Homo sapiens_hsa049700.45327484
149Glutathione metabolism_Homo sapiens_hsa004800.42249708
150GABAergic synapse_Homo sapiens_hsa047270.42057805
151Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.41521687
152Gastric acid secretion_Homo sapiens_hsa049710.40304470
153Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.39182715
154Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.38923903
155Glutamatergic synapse_Homo sapiens_hsa047240.38579460
156Metabolic pathways_Homo sapiens_hsa011000.36618965
157Phototransduction_Homo sapiens_hsa047440.35975004
158Drug metabolism - other enzymes_Homo sapiens_hsa009830.34998358
159Malaria_Homo sapiens_hsa051440.34478980
160Vascular smooth muscle contraction_Homo sapiens_hsa042700.34222090
161NOD-like receptor signaling pathway_Homo sapiens_hsa046210.34008842
162Hippo signaling pathway_Homo sapiens_hsa043900.33378814
163Allograft rejection_Homo sapiens_hsa053300.32848978
164Prion diseases_Homo sapiens_hsa050200.32181301
165Circadian entrainment_Homo sapiens_hsa047130.31586273
166Chemical carcinogenesis_Homo sapiens_hsa052040.30758381
167Jak-STAT signaling pathway_Homo sapiens_hsa046300.30149387
168RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.29166455
169B cell receptor signaling pathway_Homo sapiens_hsa046620.28138623

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