HOXB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with pancreatic cancer. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1outer ear morphogenesis (GO:0042473)5.16778124
2ribosomal small subunit assembly (GO:0000028)5.13301642
3mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)5.11009331
4mesenchymal to epithelial transition (GO:0060231)4.61162302
5viral transcription (GO:0019083)4.40725346
6G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.36235062
7regulation of apoptotic process involved in morphogenesis (GO:1902337)4.31089387
8regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.30683688
9Arp2/3 complex-mediated actin nucleation (GO:0034314)4.22294399
10definitive hemopoiesis (GO:0060216)4.20764995
11mesenchymal cell differentiation involved in kidney development (GO:0072161)4.10053840
12mesenchymal cell differentiation involved in renal system development (GO:2001012)4.10053840
13translational termination (GO:0006415)4.08159097
14proximal/distal pattern formation (GO:0009954)4.07308017
15metanephric epithelium development (GO:0072207)4.03896875
16positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.00267133
17metanephric mesenchyme development (GO:0072075)3.96658666
18positive regulation of gamma-delta T cell activation (GO:0046645)3.91948188
19nephron tubule morphogenesis (GO:0072078)3.85193718
20nephron epithelium morphogenesis (GO:0072088)3.85193718
21negative regulation of cell fate specification (GO:0009996)3.83879603
22maturation of SSU-rRNA (GO:0030490)3.83825323
23cytidine metabolic process (GO:0046087)3.81627173
24cytidine catabolic process (GO:0006216)3.81627173
25cytidine deamination (GO:0009972)3.81627173
26* facial nerve structural organization (GO:0021612)3.81562157
27* embryonic skeletal system morphogenesis (GO:0048704)3.80422265
28paraxial mesoderm development (GO:0048339)3.80229565
29kidney mesenchyme development (GO:0072074)3.79900403
30mesonephros development (GO:0001823)3.76293815
31metanephric nephron tubule development (GO:0072234)3.75429178
32metanephric tubule development (GO:0072170)3.75429178
33positive regulation of B cell differentiation (GO:0045579)3.71518117
34pattern specification involved in kidney development (GO:0061004)3.67185429
35collecting duct development (GO:0072044)3.65961909
36polarized epithelial cell differentiation (GO:0030859)3.60047752
37translational elongation (GO:0006414)3.59185909
38planar cell polarity pathway involved in neural tube closure (GO:0090179)3.51484096
39metanephric nephron epithelium development (GO:0072243)3.51156855
40actin nucleation (GO:0045010)3.48294277
41pyrimidine ribonucleoside catabolic process (GO:0046133)3.47329659
42deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.44001004
433-UTR-mediated mRNA stabilization (GO:0070935)3.43866468
44regulation of stem cell maintenance (GO:2000036)3.43152655
45DNA deamination (GO:0045006)3.41363572
46cranial nerve morphogenesis (GO:0021602)3.41171662
47regulation of gamma-delta T cell differentiation (GO:0045586)3.41059099
48neural crest cell development (GO:0014032)3.37120652
49chondrocyte proliferation (GO:0035988)3.34959998
50SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.32211375
51nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.29248359
52viral life cycle (GO:0019058)3.28691575
53ribosomal small subunit biogenesis (GO:0042274)3.28322803
54branching involved in ureteric bud morphogenesis (GO:0001658)3.28201474
55positive thymic T cell selection (GO:0045059)3.24239991
56DNA damage induced protein phosphorylation (GO:0006975)3.22553134
57protein targeting to ER (GO:0045047)3.22179772
58regulation of heart morphogenesis (GO:2000826)3.21907312
59regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.21303690
60cell differentiation involved in metanephros development (GO:0072202)3.21102613
61non-canonical Wnt signaling pathway (GO:0035567)3.19732931
62cotranslational protein targeting to membrane (GO:0006613)3.18987955
63positive regulation of odontogenesis (GO:0042482)3.18131956
64regulation of B cell differentiation (GO:0045577)3.17838154
65* skeletal system morphogenesis (GO:0048705)3.17397917
66establishment of planar polarity (GO:0001736)3.16498550
67establishment of tissue polarity (GO:0007164)3.16498550
68positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.15980620
69respiratory tube development (GO:0030323)3.15477447
70nuclear envelope reassembly (GO:0031468)3.14799996
71mitotic nuclear envelope reassembly (GO:0007084)3.14799996
72vitamin catabolic process (GO:0009111)3.13695028
73fat-soluble vitamin catabolic process (GO:0042363)3.13695028
74urogenital system development (GO:0001655)3.12893586
75negative regulation of erythrocyte differentiation (GO:0045647)3.12754235
76COPI coating of Golgi vesicle (GO:0048205)3.11241716
77Golgi transport vesicle coating (GO:0048200)3.11241716
78mesenchymal cell development (GO:0014031)3.06530669
79thyroid gland development (GO:0030878)3.06332056
80ribosomal large subunit biogenesis (GO:0042273)3.05903809
81establishment of protein localization to endoplasmic reticulum (GO:0072599)3.05325146
82mesonephric tubule development (GO:0072164)3.04677963
83UV protection (GO:0009650)3.01929942
84thymic T cell selection (GO:0045061)3.01538990
85cellular protein complex disassembly (GO:0043624)3.00362327
86regulation of mesenchymal cell apoptotic process (GO:2001053)2.99523199
87mature B cell differentiation involved in immune response (GO:0002313)2.98354336
88mesonephric epithelium development (GO:0072163)2.97837561
89mucosal-associated lymphoid tissue development (GO:0048537)2.96926666
90Peyers patch development (GO:0048541)2.96926666
91negative regulation of embryonic development (GO:0045992)2.94869789
92wound healing, spreading of epidermal cells (GO:0035313)2.93198570
93protein localization to endoplasmic reticulum (GO:0070972)2.93100764
94translational initiation (GO:0006413)2.92048629
95mesenchymal-epithelial cell signaling (GO:0060638)2.90265169
96metanephros development (GO:0001656)2.89818478
97middle ear morphogenesis (GO:0042474)2.88891429
98mesodermal cell differentiation (GO:0048333)2.88192915
99positive regulation of lamellipodium assembly (GO:0010592)2.88054462
100desmosome organization (GO:0002934)2.86694433
101renal tubule morphogenesis (GO:0061333)2.85924051
102glomerulus development (GO:0032835)2.85096269
103face development (GO:0060324)2.84938440
104Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.84773811
105mesenchyme development (GO:0060485)2.84728669
106cell proliferation involved in metanephros development (GO:0072203)2.84443589
107nephron epithelium development (GO:0072009)2.83131532
108negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.82752946
109* cranial nerve structural organization (GO:0021604)2.82305032
110pinocytosis (GO:0006907)2.82227071
111* embryonic organ morphogenesis (GO:0048562)2.82219316
112negative regulation of metanephros development (GO:0072217)2.81979124
113cochlea morphogenesis (GO:0090103)2.81660889
114nephron tubule formation (GO:0072079)2.81483229
115regulation of mitotic spindle organization (GO:0060236)2.81425045
116protein complex disassembly (GO:0043241)2.80964063
117establishment of apical/basal cell polarity (GO:0035089)2.80580958
118embryonic skeletal joint morphogenesis (GO:0060272)2.79865778
119glomerular basement membrane development (GO:0032836)2.79710758
120lymph vessel development (GO:0001945)2.79327577
121notochord development (GO:0030903)2.78856846
122DNA unwinding involved in DNA replication (GO:0006268)2.77651234
123positive regulation of natural killer cell differentiation (GO:0032825)2.77228302
124positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.77102435
125lung-associated mesenchyme development (GO:0060484)2.76046501
126cartilage morphogenesis (GO:0060536)2.74010978
127cell migration involved in heart development (GO:0060973)2.72898756
128regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.70867649
129megakaryocyte development (GO:0035855)2.70701380
130nephron tubule development (GO:0072080)2.69824284
131regulation of establishment of planar polarity (GO:0090175)2.69303576
132negative T cell selection (GO:0043383)2.69086426
133mitochondrial calcium ion transport (GO:0006851)2.67933691
134grooming behavior (GO:0007625)2.67508107
135regulation of B cell receptor signaling pathway (GO:0050855)2.67363270
136positive regulation of interleukin-8 secretion (GO:2000484)2.67000798
137negative thymic T cell selection (GO:0045060)2.66558374
138NIK/NF-kappaB signaling (GO:0038061)2.63659516
139protoporphyrinogen IX metabolic process (GO:0046501)2.63227283
140regulation of gamma-delta T cell activation (GO:0046643)2.62687275
141protein heterotrimerization (GO:0070208)2.58378976
142protoporphyrinogen IX biosynthetic process (GO:0006782)2.56957768
143blood vessel maturation (GO:0001955)2.56816485
144purine deoxyribonucleotide catabolic process (GO:0009155)2.53874323
145T cell migration (GO:0072678)2.52702012
146regulation of mammary gland epithelial cell proliferation (GO:0033599)2.52626380
147formation of translation preinitiation complex (GO:0001731)2.52136213
148trophectodermal cell differentiation (GO:0001829)2.51963380
149regulation of erythrocyte differentiation (GO:0045646)2.51817333
150base-excision repair, AP site formation (GO:0006285)2.51348457
151negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.51095763
152negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.51014478
153positive regulation of granulocyte differentiation (GO:0030854)2.48508942
154protein retention in ER lumen (GO:0006621)2.44880635
155positive regulation of blood vessel endothelial cell migration (GO:0043536)2.41417052
156negative regulation of biomineral tissue development (GO:0070168)2.40507555
157protein maturation by protein folding (GO:0022417)2.40177808
158positive T cell selection (GO:0043368)2.39949329
159regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.38898430
160antigen processing and presentation of endogenous antigen (GO:0019883)2.38883710
161negative regulation of necroptotic process (GO:0060546)2.36192068
162morphogenesis of an epithelial fold (GO:0060571)2.36031293
163tolerance induction (GO:0002507)2.35896400
164entrainment of circadian clock by photoperiod (GO:0043153)2.35779013
165negative regulation of bone mineralization (GO:0030502)2.35200112
166maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.34803684
167embryonic viscerocranium morphogenesis (GO:0048703)2.32020093
168antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.29464821
169positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.27314681
170regulation of interleukin-2 biosynthetic process (GO:0045076)2.27171612
171negative regulation of T cell apoptotic process (GO:0070233)2.26856521
172granulocyte differentiation (GO:0030851)2.26140566
173membrane raft organization (GO:0031579)2.24701563
174retinoic acid receptor signaling pathway (GO:0048384)2.24624666
175positive regulation of myotube differentiation (GO:0010831)2.23830211
176negative regulation of stress fiber assembly (GO:0051497)2.21693978
177mammary gland epithelial cell differentiation (GO:0060644)2.21606577
178hematopoietic stem cell differentiation (GO:0060218)2.21390658
179embryonic heart tube development (GO:0035050)2.20163882
180positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.20125452

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.48666618
2E2F7_22180533_ChIP-Seq_HELA_Human5.80411591
3CHD7_19251738_ChIP-ChIP_MESCs_Mouse4.10701285
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.24004198
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.19477542
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.08195579
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.98667214
8TP63_19390658_ChIP-ChIP_HaCaT_Human2.93935545
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.88441879
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.74592339
11MYC_22102868_ChIP-Seq_BL_Human2.64761196
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.61596894
13TP53_20018659_ChIP-ChIP_R1E_Mouse2.51883184
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.47033801
15KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.34712022
16KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.34712022
17KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.34712022
18STAT6_21828071_ChIP-Seq_BEAS2B_Human2.31224928
19ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.29238481
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.25367190
21KLF4_19030024_ChIP-ChIP_MESCs_Mouse2.21521878
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.10198015
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.08054147
24KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.06564103
25IRF8_22096565_ChIP-ChIP_GC-B_Human2.05833824
26PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.02465946
27AR_21909140_ChIP-Seq_LNCAP_Human2.01698217
28* MAF_26560356_Chip-Seq_TH1_Human1.96484696
29MYC_19079543_ChIP-ChIP_MESCs_Mouse1.96149626
30CDX2_20551321_ChIP-Seq_CACO-2_Human1.93551063
31UTX_26944678_Chip-Seq_JUKART_Human1.93172484
32MAF_26560356_Chip-Seq_TH2_Human1.92038520
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.91541182
34SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.91351361
35* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.84148356
36POU5F1_16153702_ChIP-ChIP_HESCs_Human1.83653695
37RBPJ_22232070_ChIP-Seq_NCS_Mouse1.83083594
38ESR1_21235772_ChIP-Seq_MCF-7_Human1.82286291
39SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.82049686
40* ELK3_25401928_ChIP-Seq_HUVEC_Human1.81692366
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.81664642
42CLOCK_20551151_ChIP-Seq_293T_Human1.78427828
43E2F4_17652178_ChIP-ChIP_JURKAT_Human1.74909020
44VDR_24763502_ChIP-Seq_THP-1_Human1.72780407
45NCOR1_26117541_ChIP-Seq_K562_Human1.70905517
46CIITA_25753668_ChIP-Seq_RAJI_Human1.70588529
47JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.70489662
48* EED_16625203_ChIP-ChIP_MESCs_Mouse1.69367804
49KDM2B_26808549_Chip-Seq_DND41_Human1.66051296
50WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.65583499
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.64858960
52MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.64260774
53TRIM28_21343339_ChIP-Seq_HEK293_Human1.61412977
54SOX2_18555785_ChIP-Seq_MESCs_Mouse1.58295547
55MYB_26560356_Chip-Seq_TH2_Human1.57099150
56ELF1_20517297_ChIP-Seq_JURKAT_Human1.56775352
57* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.56131511
58KDM2B_26808549_Chip-Seq_SUP-B15_Human1.53859176
59CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.52504240
60* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.51026428
61SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.50750113
62SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.50750113
63SCL_19346495_ChIP-Seq_HPC-7_Human1.48057897
64STAT4_19710469_ChIP-ChIP_TH1__Mouse1.47328394
65TET1_21451524_ChIP-Seq_MESCs_Mouse1.47214197
66TCF7_22412390_ChIP-Seq_EML_Mouse1.46966594
67MYB_26560356_Chip-Seq_TH1_Human1.46846745
68DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.46758488
69TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46291165
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.46008426
71* TTF2_22483619_ChIP-Seq_HELA_Human1.45762919
72XRN2_22483619_ChIP-Seq_HELA_Human1.41981631
73CTCF_27219007_Chip-Seq_ERYTHROID_Human1.41798824
74SPI1_23547873_ChIP-Seq_NB4_Human1.41627855
75MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.40129598
76MYC_19030024_ChIP-ChIP_MESCs_Mouse1.39957304
77ETS1_20019798_ChIP-Seq_JURKAT_Human1.38095614
78RUNX1_22412390_ChIP-Seq_EML_Mouse1.38029905
79KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.37171791
80ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.36351710
81TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35394082
82NOTCH1_21737748_ChIP-Seq_TLL_Human1.34716282
83EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.32742982
84TCF3_18692474_ChIP-Seq_MEFs_Mouse1.32640257
85GATA2_22383799_ChIP-Seq_G1ME_Mouse1.30947788
86NANOG_16153702_ChIP-ChIP_HESCs_Human1.29581409
87RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.29544610
88SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.29071970
89P68_20966046_ChIP-Seq_HELA_Human1.28780478
90CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.28504639
91MYC_18358816_ChIP-ChIP_MESCs_Mouse1.28309585
92ELF1_17652178_ChIP-ChIP_JURKAT_Human1.28059354
93ZNF263_19887448_ChIP-Seq_K562_Human1.27182522
94BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.26524448
95MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.26032608
96STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.25448833
97BRD4_27068464_Chip-Seq_AML-cells_Mouse1.24694712
98HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.24369276
99BCL6_27268052_Chip-Seq_Bcells_Human1.23096913
100GATA1_19941826_ChIP-Seq_K562_Human1.21537372
101NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.21436760
102NELFA_20434984_ChIP-Seq_ESCs_Mouse1.21143471
103CTCF_21964334_Chip-Seq_Bcells_Human1.20177623
104THAP11_20581084_ChIP-Seq_MESCs_Mouse1.18374467
105TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17257595
106CTCF_26484167_Chip-Seq_Bcells_Mouse1.16945970
107WT1_19549856_ChIP-ChIP_CCG9911_Human1.16659822
108KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.16592809
109DCP1A_22483619_ChIP-Seq_HELA_Human1.16018569
110NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.15641932
111E2F1_18555785_ChIP-Seq_MESCs_Mouse1.14462288
112EGR1_19374776_ChIP-ChIP_THP-1_Human1.14348914
113THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.13324651
114SOX2_18692474_ChIP-Seq_MEFs_Mouse1.12683430
115GABP_19822575_ChIP-Seq_HepG2_Human1.12613413
116GATA1_22383799_ChIP-Seq_G1ME_Mouse1.12505697
117KDM2B_26808549_Chip-Seq_JURKAT_Human1.11863184
118E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.11719970
119CTCF_21964334_ChIP-Seq_BJAB-B_Human1.09721574
120TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08703956
121* CBX2_27304074_Chip-Seq_ESCs_Mouse1.08351179
122ZFX_18555785_ChIP-Seq_MESCs_Mouse1.07853715
123TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07510878
124ERG_20887958_ChIP-Seq_HPC-7_Mouse1.04214576
125PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04178909
126BCOR_27268052_Chip-Seq_Bcells_Human1.03957942
127SPI1_23127762_ChIP-Seq_K562_Human1.03835452
128* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.03284876
129FOXP3_21729870_ChIP-Seq_TREG_Human1.02529827
130ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.01775517
131UBF1/2_26484160_Chip-Seq_HMECs_Human1.01604210
132LXR_22292898_ChIP-Seq_THP-1_Human1.01496984
133TP53_22127205_ChIP-Seq_IMR90_Human1.00856600
134CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.00747120
135STAT3_1855785_ChIP-Seq_MESCs_Mouse1.00668387
136ESR2_21235772_ChIP-Seq_MCF-7_Human1.00589956
137CREB1_15753290_ChIP-ChIP_HEK293T_Human1.00031571
138POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.97985194
139P63_26484246_Chip-Seq_KERATINOCYTES_Human0.96994828
140RACK7_27058665_Chip-Seq_MCF-7_Human0.96435463
141STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.96006803
142VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.95752010
143* EZH2_27304074_Chip-Seq_ESCs_Mouse0.94062891
144ZFP281_18757296_ChIP-ChIP_E14_Mouse0.93938410
145SA1_27219007_Chip-Seq_ERYTHROID_Human0.93405680
146CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.93302185
147SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.92777837
148E2F1_21310950_ChIP-Seq_MCF-7_Human0.92140709
149CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.91540421
150SOX2_16153702_ChIP-ChIP_HESCs_Human0.90940151
151VDR_21846776_ChIP-Seq_THP-1_Human0.90488525
152ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.90137722
153OCT4_18692474_ChIP-Seq_MEFs_Mouse0.89400069
154SRY_22984422_ChIP-ChIP_TESTIS_Rat0.88206785
155UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.87733034
156TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86597076
157ATF3_27146783_Chip-Seq_COLON_Human0.86048590
158CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.85728682
159HIF1A_21447827_ChIP-Seq_MCF-7_Human0.85306416
160HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.85274597
161* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.84674598
162RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.83652142

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology3.94396028
2MP0002249_abnormal_larynx_morphology3.51411081
3MP0003763_abnormal_thymus_physiology2.95203003
4MP0005623_abnormal_meninges_morphology2.79239397
5MP0003942_abnormal_urinary_system2.69171819
6* MP0003385_abnormal_body_wall2.62640036
7MP0009250_abnormal_appendicular_skeleto2.55876173
8MP0003941_abnormal_skin_development2.51817522
9MP0003279_aneurysm2.49370585
10MP0009333_abnormal_splenocyte_physiolog2.38812696
11MP0010368_abnormal_lymphatic_system2.37090356
12MP0002877_abnormal_melanocyte_morpholog2.32324826
13MP0002932_abnormal_joint_morphology2.29786010
14MP0003123_paternal_imprinting2.28181738
15MP0000049_abnormal_middle_ear2.23104702
16MP0000534_abnormal_ureter_morphology2.21181751
17MP0008438_abnormal_cutaneous_collagen2.21103795
18MP0000678_abnormal_parathyroid_gland2.12260933
19MP0006054_spinal_hemorrhage2.10241516
20MP0000681_abnormal_thyroid_gland2.08708403
21MP0003436_decreased_susceptibility_to2.04105885
22MP0003705_abnormal_hypodermis_morpholog1.99469282
23MP0005503_abnormal_tendon_morphology1.96893122
24MP0005671_abnormal_response_to1.93216423
25MP0005275_abnormal_skin_tensile1.92299240
26MP0001545_abnormal_hematopoietic_system1.89845944
27MP0005397_hematopoietic_system_phenotyp1.89845944
28MP0003315_abnormal_perineum_morphology1.88756997
29MP0004272_abnormal_basement_membrane1.88499231
30MP0000013_abnormal_adipose_tissue1.84022877
31MP0000703_abnormal_thymus_morphology1.79056471
32MP0009053_abnormal_anal_canal1.78338464
33MP0005464_abnormal_platelet_physiology1.75798640
34MP0002398_abnormal_bone_marrow1.74342708
35MP0000537_abnormal_urethra_morphology1.72026455
36MP0000566_synostosis1.71717939
37MP0001879_abnormal_lymphatic_vessel1.70455552
38MP0002938_white_spotting1.69711908
39MP0005508_abnormal_skeleton_morphology1.64005123
40MP0001835_abnormal_antigen_presentation1.62931081
41MP0002282_abnormal_trachea_morphology1.57846250
42MP0002722_abnormal_immune_system1.56292339
43MP0005451_abnormal_body_composition1.54009134
44MP0005000_abnormal_immune_tolerance1.50750507
45MP0000516_abnormal_urinary_system1.45099002
46MP0005367_renal/urinary_system_phenotyp1.45099002
47MP0001873_stomach_inflammation1.44586053
48MP0003938_abnormal_ear_development1.44381976
49MP0003122_maternal_imprinting1.42306453
50MP0000759_abnormal_skeletal_muscle1.40340305
51MP0002177_abnormal_outer_ear1.38532754
52MP0002420_abnormal_adaptive_immunity1.38117818
53MP0001819_abnormal_immune_cell1.37760289
54MP0001958_emphysema1.36402103
55MP0000733_abnormal_muscle_development1.35190734
56MP0003937_abnormal_limbs/digits/tail_de1.34921218
57MP0004858_abnormal_nervous_system1.34744405
58MP0000749_muscle_degeneration1.34669562
59MP0000689_abnormal_spleen_morphology1.33647868
60MP0002429_abnormal_blood_cell1.31774489
61MP0000716_abnormal_immune_system1.31147247
62MP0000762_abnormal_tongue_morphology1.30827504
63MP0001881_abnormal_mammary_gland1.30797989
64MP0003567_abnormal_fetal_cardiomyocyte1.29327188
65MP0000383_abnormal_hair_follicle1.27849485
66MP0000003_abnormal_adipose_tissue1.27585122
67MP0003935_abnormal_craniofacial_develop1.26757847
68MP0010234_abnormal_vibrissa_follicle1.26462833
69MP0000858_altered_metastatic_potential1.22726049
70MP0002111_abnormal_tail_morphology1.22722094
71MP0002723_abnormal_immune_serum1.22528324
72MP0008932_abnormal_embryonic_tissue1.21943264
73* MP0002114_abnormal_axial_skeleton1.21737360
74MP0002148_abnormal_hypersensitivity_rea1.21709663
75MP0003828_pulmonary_edema1.21190128
76MP0010352_gastrointestinal_tract_polyps1.20242112
77MP0001348_abnormal_lacrimal_gland1.19827895
78MP0001270_distended_abdomen1.18935993
79MP0000163_abnormal_cartilage_morphology1.18927605
80MP0005025_abnormal_response_to1.18287808
81MP0003566_abnormal_cell_adhesion1.17629815
82MP0004185_abnormal_adipocyte_glucose1.16693897
83MP0002933_joint_inflammation1.16265732
84MP0002109_abnormal_limb_morphology1.15968151
85MP0003115_abnormal_respiratory_system1.15379726
86MP0002019_abnormal_tumor_incidence1.14397972
87MP0003191_abnormal_cellular_cholesterol1.14293546
88* MP0000432_abnormal_head_morphology1.14237807
89MP0003121_genomic_imprinting1.13871003
90MP0009278_abnormal_bone_marrow1.13756850
91MP0000428_abnormal_craniofacial_morphol1.12376461
92MP0002233_abnormal_nose_morphology1.11560315
93MP0003755_abnormal_palate_morphology1.11106966
94MP0002060_abnormal_skin_morphology1.09906698
95MP0002405_respiratory_system_inflammati1.09658656
96MP0003119_abnormal_digestive_system1.09595873
97MP0001800_abnormal_humoral_immune1.09423280
98MP0002098_abnormal_vibrissa_morphology1.08764219
99MP0002452_abnormal_antigen_presenting1.07389207
100MP0001542_abnormal_bone_strength1.07302158
101MP0005501_abnormal_skin_physiology1.06778652
102MP0002116_abnormal_craniofacial_bone1.05627656
103MP0003693_abnormal_embryo_hatching1.04278385
104MP0003878_abnormal_ear_physiology1.04188281
105MP0005377_hearing/vestibular/ear_phenot1.04188281
106MP0009785_altered_susceptibility_to1.03280275
107MP0002796_impaired_skin_barrier1.02098527
108MP0005330_cardiomyopathy1.01302595
109MP0005023_abnormal_wound_healing1.00578380
110MP0008007_abnormal_cellular_replicative0.99815769
111MP0003786_premature_aging0.99732901
112MP0003866_abnormal_defecation0.99555690
113MP0002113_abnormal_skeleton_development0.99383124
114MP0003045_fibrosis0.99212287
115MP0000767_abnormal_smooth_muscle0.97642586
116MP0002115_abnormal_skeleton_extremities0.96729703
117MP0000467_abnormal_esophagus_morphology0.95721007
118MP0002089_abnormal_postnatal_growth/wei0.95029723
119MP0002132_abnormal_respiratory_system0.94917083
120MP0001727_abnormal_embryo_implantation0.94403063
121MP0000343_altered_response_to0.93969993
122MP0001849_ear_inflammation0.93750239
123MP0001915_intracranial_hemorrhage0.93356665
124MP0001853_heart_inflammation0.93083491
125MP0002234_abnormal_pharynx_morphology0.92492708
126MP0009379_abnormal_foot_pigmentation0.92377815
127MP0000490_abnormal_crypts_of0.91954277
128MP0001661_extended_life_span0.91234491
129MP0004197_abnormal_fetal_growth/weight/0.90875122
130* MP0002085_abnormal_embryonic_tissue0.90713529
131MP0006036_abnormal_mitochondrial_physio0.90692912
132MP0002396_abnormal_hematopoietic_system0.90458607
133MP0003448_altered_tumor_morphology0.90334549
134MP0004947_skin_inflammation0.89702535
135MP0009384_cardiac_valve_regurgitation0.89381070
136MP0005375_adipose_tissue_phenotype0.88605029
137MP0002419_abnormal_innate_immunity0.87041660
138MP0000685_abnormal_immune_system0.86366075
139MP0002135_abnormal_kidney_morphology0.86297939
140MP0004134_abnormal_chest_morphology0.84653927
141MP0003300_gastrointestinal_ulcer0.84108212
142MP0005058_abnormal_lysosome_morphology0.83574213
143MP0000465_gastrointestinal_hemorrhage0.83091315
144MP0009931_abnormal_skin_appearance0.82769957
145MP0010678_abnormal_skin_adnexa0.82585041
146MP0002166_altered_tumor_susceptibility0.82536808
147MP0001790_abnormal_immune_system0.81941587
148MP0005387_immune_system_phenotype0.81941587
149MP0003111_abnormal_nucleus_morphology0.81067209
150MP0002108_abnormal_muscle_morphology0.80084174
151MP0000579_abnormal_nail_morphology0.79061808
152MP0002925_abnormal_cardiovascular_devel0.78738440
153MP0009697_abnormal_copulation0.78656729
154MP0001340_abnormal_eyelid_morphology0.78497954
155MP0002009_preneoplasia0.77753363
156MP0001533_abnormal_skeleton_physiology0.77239923
157MP0001614_abnormal_blood_vessel0.77086578
158MP0004808_abnormal_hematopoietic_stem0.76912326
159MP0002084_abnormal_developmental_patter0.76241318
160MP0004381_abnormal_hair_follicle0.76171502
161MP0005390_skeleton_phenotype0.75570057
162MP0010630_abnormal_cardiac_muscle0.75356080
163MP0003795_abnormal_bone_structure0.74639115
164MP0002653_abnormal_ependyma_morphology0.73181310
165MP0002928_abnormal_bile_duct0.71747779
166MP0000372_irregular_coat_pigmentation0.71217972
167MP0002896_abnormal_bone_mineralization0.70528400
168MP0005408_hypopigmentation0.70441442
169MP0005084_abnormal_gallbladder_morpholo0.69049459

Predicted human phenotypes

RankGene SetZ-score
1Renal duplication (HP:0000075)4.15339064
2Protrusio acetabuli (HP:0003179)3.94450006
3Hypertensive crisis (HP:0100735)3.42059144
4Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.37607377
5Short 4th metacarpal (HP:0010044)3.37607377
6Premature rupture of membranes (HP:0001788)3.36506518
7Increased variability in muscle fiber diameter (HP:0003557)3.29296409
8Reticulocytopenia (HP:0001896)3.28509975
9Elevated erythrocyte sedimentation rate (HP:0003565)3.24055596
10Cerebral aneurysm (HP:0004944)3.22140786
11Mesangial abnormality (HP:0001966)3.18602642
12Abnormality of skeletal muscle fiber size (HP:0012084)3.17420072
13Type 1 muscle fiber predominance (HP:0003803)3.11963701
14Atrophic scars (HP:0001075)3.02739069
15Autoimmune hemolytic anemia (HP:0001890)3.00026894
16Bowel diverticulosis (HP:0005222)2.97652941
17Abnormal lung lobation (HP:0002101)2.97015169
18Chronic obstructive pulmonary disease (HP:0006510)2.89992810
19Obstructive lung disease (HP:0006536)2.89992810
20Spinal rigidity (HP:0003306)2.89807299
21Nonimmune hydrops fetalis (HP:0001790)2.84626866
22Abnormality of cells of the erythroid lineage (HP:0012130)2.79570587
23Centrally nucleated skeletal muscle fibers (HP:0003687)2.79037498
24Truncus arteriosus (HP:0001660)2.77041513
25Shallow orbits (HP:0000586)2.70968136
26Bicornuate uterus (HP:0000813)2.69535762
27Down-sloping shoulders (HP:0200021)2.69317710
28Short middle phalanx of the 5th finger (HP:0004220)2.66788236
29Genu recurvatum (HP:0002816)2.65145243
30Unilateral renal agenesis (HP:0000122)2.64494064
31Soft skin (HP:0000977)2.64225161
32Abnormality of the tricuspid valve (HP:0001702)2.59718420
33Abnormality of the 4th metacarpal (HP:0010012)2.55749206
34Elbow flexion contracture (HP:0002987)2.52686440
35Exercise-induced myalgia (HP:0003738)2.49371130
36Esophageal neoplasm (HP:0100751)2.49237930
37Neoplasm of head and neck (HP:0012288)2.49237930
38Selective tooth agenesis (HP:0001592)2.47526913
39Natal tooth (HP:0000695)2.47299822
40Bladder diverticulum (HP:0000015)2.46001997
41Mesomelia (HP:0003027)2.45870213
42Hyperthyroidism (HP:0000836)2.44599990
43Abnormal number of erythroid precursors (HP:0012131)2.43908430
44Embryonal renal neoplasm (HP:0011794)2.43127498
45Abnormality of oral frenula (HP:0000190)2.41282846
46Slender build (HP:0001533)2.38874456
47Nephroblastoma (Wilms tumor) (HP:0002667)2.37953111
48Shawl scrotum (HP:0000049)2.37869095
49Ankle contracture (HP:0006466)2.36978616
50Aplasia/Hypoplasia of the thymus (HP:0010515)2.34698660
51Colon cancer (HP:0003003)2.33419273
52Fragile skin (HP:0001030)2.29624829
53Abnormality of the 2nd finger (HP:0004100)2.29440896
54Granulocytopenia (HP:0001913)2.28942747
55Broad toe (HP:0001837)2.28770102
56Petechiae (HP:0000967)2.28712783
57Abnormality of the peritoneum (HP:0002585)2.27916279
58Camptodactyly of toe (HP:0001836)2.27272900
59Myopathic facies (HP:0002058)2.27167963
60Generalized amyotrophy (HP:0003700)2.26312743
61Dilatation of the ascending aorta (HP:0005111)2.25915226
62Recurrent viral infections (HP:0004429)2.24436747
63Easy fatigability (HP:0003388)2.24229523
64Seborrheic dermatitis (HP:0001051)2.23482169
65Aplasia/Hypoplasia of the sacrum (HP:0008517)2.23446256
66Abnormality of T cell physiology (HP:0011840)2.22376979
67Atelectasis (HP:0100750)2.19550117
68Aortic dissection (HP:0002647)2.19075611
69Abnormality of T cells (HP:0002843)2.19029422
70Redundant skin (HP:0001582)2.17462744
71Midline defect of the nose (HP:0004122)2.17320736
72Gastrointestinal inflammation (HP:0004386)2.16974830
73Intestinal atresia (HP:0011100)2.16404397
74Abnormal delayed hypersensitivity skin test (HP:0002963)2.14927653
75Joint stiffness (HP:0001387)2.14428155
76Abnormality of the umbilical cord (HP:0010881)2.13284665
77Broad metatarsal (HP:0001783)2.12820054
78Muscle stiffness (HP:0003552)2.12548162
79Flexion contracture of toe (HP:0005830)2.11668930
80Joint contractures involving the joints of the feet (HP:0100492)2.11668930
81Polycythemia (HP:0001901)2.11064282
82Aortic aneurysm (HP:0004942)2.10567901
83Abnormality of the heme biosynthetic pathway (HP:0010472)2.08524263
84Glomerulosclerosis (HP:0000096)2.08402616
85Stridor (HP:0010307)2.08301469
86Neoplasm of the adrenal cortex (HP:0100641)2.07855971
87Abnormal umbilical cord blood vessels (HP:0011403)2.06570451
88Single umbilical artery (HP:0001195)2.06570451
89Abnormality of the fetal cardiovascular system (HP:0010948)2.06570451
90Hypercalciuria (HP:0002150)2.05747959
91Breech presentation (HP:0001623)2.05089940
92Aplastic anemia (HP:0001915)2.04852372
93Ankyloglossia (HP:0010296)2.04244242
94Ragged-red muscle fibers (HP:0003200)2.03343956
95Vertebral compression fractures (HP:0002953)2.03128876
96Abnormality of dentin (HP:0010299)1.98982576
97Agammaglobulinemia (HP:0004432)1.97527236
98Partial duplication of the phalanx of hand (HP:0009999)1.97166619
99Ileus (HP:0002595)1.96738643
100Morphological abnormality of the middle ear (HP:0008609)1.96737131
101Embryonal neoplasm (HP:0002898)1.96263346
102Long toe (HP:0010511)1.94531433
103Increased connective tissue (HP:0009025)1.94170576
104Biconcave vertebral bodies (HP:0004586)1.93576165
105Stage 5 chronic kidney disease (HP:0003774)1.92465407
106Stenosis of the external auditory canal (HP:0000402)1.92009884
107Absent eyelashes (HP:0000561)1.90724146
108Venous insufficiency (HP:0005293)1.90692891
109Venous abnormality (HP:0002624)1.89296950
110Acute lymphatic leukemia (HP:0006721)1.89274639
111Thrombocytosis (HP:0001894)1.89073971
112Abnormality of the columella (HP:0009929)1.88609270
113Microvesicular hepatic steatosis (HP:0001414)1.87739769
114Abnormal hemoglobin (HP:0011902)1.87588420
115Neonatal short-limb short stature (HP:0008921)1.87322126
116Sprengel anomaly (HP:0000912)1.86897150
117Facial shape deformation (HP:0011334)1.85951812
118Potter facies (HP:0002009)1.85951812
119Cardiovascular calcification (HP:0011915)1.85879110
120Mildly elevated creatine phosphokinase (HP:0008180)1.84759725
121Germ cell neoplasia (HP:0100728)1.84733449
122Hypotrichosis (HP:0001006)1.84563196
123Patellar dislocation (HP:0002999)1.84498379
124Disproportionate tall stature (HP:0001519)1.84397854
125Recurrent fungal infections (HP:0002841)1.83760549
126Abnormality of the parietal bone (HP:0002696)1.83186349
127T lymphocytopenia (HP:0005403)1.82730163
128Panhypogammaglobulinemia (HP:0003139)1.82426601
129Ulnar deviation of the wrist (HP:0003049)1.82201420
130Prolonged bleeding time (HP:0003010)1.81823635
131Hepatoblastoma (HP:0002884)1.81620650
132Recurrent corneal erosions (HP:0000495)1.81515512
133Follicular hyperkeratosis (HP:0007502)1.81508019
134Thin bony cortex (HP:0002753)1.80737265
135Inflammation of the large intestine (HP:0002037)1.79960057
136Round ear (HP:0100830)1.77992407
137Wide anterior fontanel (HP:0000260)1.77805337
138Cellulitis (HP:0100658)1.76910576
139Abnormality of the calcaneus (HP:0008364)1.76799694
140Neonatal death (HP:0003811)1.76767958
141Elfin facies (HP:0004428)1.76529973
142Trismus (HP:0000211)1.76216561
143Abnormality of the nasolacrimal system (HP:0000614)1.75994565
144Renal dysplasia (HP:0000110)1.75984104
145Spinal cord lesions (HP:0100561)1.75836441
146Syringomyelia (HP:0003396)1.75836441
147Calcaneovalgus deformity (HP:0001848)1.75527800
148Hyperactive renin-angiotensin system (HP:0000841)1.74195018
149Increased serum ferritin (HP:0003281)1.74174563
150Gastrointestinal dysmotility (HP:0002579)1.74121376
151Focal segmental glomerulosclerosis (HP:0000097)1.72939858
152Spondylolisthesis (HP:0003302)1.72215195
153Peritonitis (HP:0002586)1.72103270
154Hypoplastic left heart (HP:0004383)1.72083344
155Wormian bones (HP:0002645)1.71777239
156Hyperacusis (HP:0010780)1.71090274
157Abnormality of the aortic arch (HP:0012303)1.70583806
158Epistaxis (HP:0000421)1.70527662
159Increased muscle lipid content (HP:0009058)1.70294985
160Myositis (HP:0100614)1.70009303
161Type I transferrin isoform profile (HP:0003642)1.69674246
162Wide cranial sutures (HP:0010537)1.69498847
163Advanced eruption of teeth (HP:0006288)1.69287457
164Hypoparathyroidism (HP:0000829)1.69209275
165Chronic mucocutaneous candidiasis (HP:0002728)1.69146985
166Recurrent cutaneous fungal infections (HP:0011370)1.69146985
167Abnormal pupillary function (HP:0007686)1.68324271
168Supernumerary spleens (HP:0009799)1.68231540
169Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.67932460
170Abnormality of the lacrimal duct (HP:0011481)1.67767529
171Vascular calcification (HP:0004934)1.67403024
172Aortic valve stenosis (HP:0001650)1.67138144
173Eosinophilia (HP:0001880)1.67096900
174Microretrognathia (HP:0000308)1.65836918
175Diastasis recti (HP:0001540)1.65785203
176Abnormality of the thymus (HP:0000777)1.65317145
177Facial cleft (HP:0002006)1.65224728
178Broad hallux (HP:0010055)1.64768562
179Deviation of the hallux (HP:0010051)1.62895261
180Blue sclerae (HP:0000592)1.62524696
181Flat cornea (HP:0007720)1.61313296
182Deformed tarsal bones (HP:0008119)1.61023057
183Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.60311382

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP2K33.88409419
2ZAK3.76413359
3TGFBR13.66903350
4TRIB33.22238342
5EPHB23.11757050
6TIE13.06114019
7TESK22.75282671
8LATS22.71748975
9MAP4K12.44758237
10PASK2.38573764
11EEF2K2.38095381
12SCYL22.30249418
13TTK2.29820357
14MKNK12.07916419
15PRPF4B2.02209046
16LATS12.01635483
17ZAP701.84266044
18CLK11.81752798
19TSSK61.76320247
20MATK1.75972518
21GRK61.75737506
22TGFBR21.71058537
23RPS6KB21.70086423
24BCKDK1.66613806
25TTN1.60116431
26ERN11.58154046
27TXK1.57680121
28IRAK31.56375257
29VRK21.53194596
30NME21.51077293
31MAP2K61.49745612
32KDR1.49227716
33PAK41.44174933
34PAK21.43058360
35EIF2AK11.42403492
36MYLK1.38101703
37MAP3K111.36759659
38SRPK11.35774244
39ADRBK21.27295827
40STK38L1.27281716
41DYRK31.26366535
42TLK11.24898049
43LRRK21.23079847
44MAP3K31.22799966
45SMG11.19233514
46MAP3K131.16987591
47WNK41.16793664
48PTK61.16374313
49BUB11.16037478
50PRKD21.15151231
51MUSK1.14712466
52MAPKAPK31.12545869
53PLK31.12469618
54CDK121.11681485
55MOS1.09898410
56MAP3K141.08013030
57MST1R1.00916294
58ARAF1.00285854
59FER0.99549559
60RPS6KA40.99178225
61MARK30.98278000
62MKNK20.95294012
63CDK70.94585597
64AURKB0.93440242
65WNK30.93440240
66STK30.91336879
67MAP3K60.90940402
68FES0.90059604
69ERBB30.87962056
70GRK10.86301515
71SIK10.85177225
72ILK0.83712069
73BLK0.83361702
74PLK10.82506306
75TAOK20.81835093
76ICK0.81609321
77RPS6KL10.80942905
78RPS6KC10.80942905
79IKBKB0.79847955
80NTRK10.79438003
81ITK0.79326867
82PDGFRA0.79116300
83RIPK40.78728200
84MET0.78650663
85PIM20.78098668
86CDC70.77597049
87WEE10.77150810
88CAMKK20.76793746
89PIK3CG0.75996611
90CDK60.75992872
91MAP2K20.75648331
92IKBKE0.75577499
93NEK20.71455368
94LCK0.71104813
95SYK0.70013213
96CHEK20.69134387
97MAPK110.68532059
98PRKCQ0.67710203
99KSR20.66490875
100RPS6KA60.63894767
101TYK20.63436073
102EIF2AK20.63377288
103HIPK20.63215053
104CDK190.62560266
105BMPR20.62344046
106MAP3K100.62072965
107EPHB10.61006520
108CDK80.60768080
109TAOK30.59788264
110CDK40.59658411
111MAP3K80.58411675
112BTK0.55926148
113TRPM70.55781217
114NEK90.55545426
115RAF10.54957080
116EPHA20.53617704
117CDK90.53446238
118TNK20.52076149
119TEC0.51585884
120AURKA0.50885696
121KIT0.49821599
122MAP3K50.49250805
123CASK0.49129901
124CAMK1D0.48494094
125MAP3K10.48352359
126PRKCH0.48090346
127BRSK20.48012694
128PAK10.47530673
129STK100.47323789
130TESK10.46978713
131BMX0.45684250
132RPS6KA20.45336659
133YES10.44651926
134ACVR1B0.44487338
135IRAK40.44471235
136JAK30.43840721
137DAPK30.43418854
138LIMK10.43002097
139CSF1R0.42914501
140ATR0.42485512
141TBK10.42059019
142PTK20.42039273
143PRKCI0.40086229
144OXSR10.39639443
145MAP3K70.39366530
146FLT30.38795062
147MTOR0.38471313
148STK160.37322394
149PKN20.36453743
150CSNK2A10.36177441
151CCNB10.34943985
152AKT10.31588329

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.46281609
2Basal cell carcinoma_Homo sapiens_hsa052173.36390883
3Primary immunodeficiency_Homo sapiens_hsa053403.32326832
4DNA replication_Homo sapiens_hsa030303.18552397
5Mismatch repair_Homo sapiens_hsa034302.65365470
6Base excision repair_Homo sapiens_hsa034102.40666293
7Nucleotide excision repair_Homo sapiens_hsa034202.39334488
8Hedgehog signaling pathway_Homo sapiens_hsa043402.36122208
9p53 signaling pathway_Homo sapiens_hsa041152.27408766
10Spliceosome_Homo sapiens_hsa030402.24902552
11Cell cycle_Homo sapiens_hsa041102.24862474
12Acute myeloid leukemia_Homo sapiens_hsa052212.10239284
13Hippo signaling pathway_Homo sapiens_hsa043902.09330426
14Cyanoamino acid metabolism_Homo sapiens_hsa004602.03780765
15T cell receptor signaling pathway_Homo sapiens_hsa046601.91594958
16ECM-receptor interaction_Homo sapiens_hsa045121.85872433
17Other glycan degradation_Homo sapiens_hsa005111.76528780
18Graft-versus-host disease_Homo sapiens_hsa053321.67079737
19Homologous recombination_Homo sapiens_hsa034401.64260488
20Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.62601379
21Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.58745591
22TGF-beta signaling pathway_Homo sapiens_hsa043501.57265857
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.57036862
24Pancreatic cancer_Homo sapiens_hsa052121.51752524
25Measles_Homo sapiens_hsa051621.50772437
26B cell receptor signaling pathway_Homo sapiens_hsa046621.49157075
27Bladder cancer_Homo sapiens_hsa052191.47977383
28Proteoglycans in cancer_Homo sapiens_hsa052051.46440553
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45453290
30One carbon pool by folate_Homo sapiens_hsa006701.43809532
31Toll-like receptor signaling pathway_Homo sapiens_hsa046201.37255938
32Allograft rejection_Homo sapiens_hsa053301.36003560
33Small cell lung cancer_Homo sapiens_hsa052221.35400338
34Autoimmune thyroid disease_Homo sapiens_hsa053201.33229900
35Retinol metabolism_Homo sapiens_hsa008301.32663319
36Viral myocarditis_Homo sapiens_hsa054161.31816427
37Non-small cell lung cancer_Homo sapiens_hsa052231.31486149
38Pyrimidine metabolism_Homo sapiens_hsa002401.31318849
39Transcriptional misregulation in cancer_Homo sapiens_hsa052021.29029456
40HTLV-I infection_Homo sapiens_hsa051661.28558695
41Adherens junction_Homo sapiens_hsa045201.27795599
42RNA transport_Homo sapiens_hsa030131.27140481
43Hematopoietic cell lineage_Homo sapiens_hsa046401.25989553
44Protein digestion and absorption_Homo sapiens_hsa049741.25466888
45Notch signaling pathway_Homo sapiens_hsa043301.23604082
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.23205309
47Fanconi anemia pathway_Homo sapiens_hsa034601.23053947
48Basal transcription factors_Homo sapiens_hsa030221.18204893
49TNF signaling pathway_Homo sapiens_hsa046681.17883603
50MicroRNAs in cancer_Homo sapiens_hsa052061.17065379
51Arachidonic acid metabolism_Homo sapiens_hsa005901.16201363
52Wnt signaling pathway_Homo sapiens_hsa043101.15925283
53Osteoclast differentiation_Homo sapiens_hsa043801.14782551
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.14293091
55Hepatitis B_Homo sapiens_hsa051611.12241879
56Focal adhesion_Homo sapiens_hsa045101.12196946
57Pathways in cancer_Homo sapiens_hsa052001.10574809
58VEGF signaling pathway_Homo sapiens_hsa043701.09257125
59Sulfur relay system_Homo sapiens_hsa041221.09072450
60Thyroid cancer_Homo sapiens_hsa052161.08772948
61Melanogenesis_Homo sapiens_hsa049161.04330391
62Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.03492772
63Leukocyte transendothelial migration_Homo sapiens_hsa046701.03154176
64Shigellosis_Homo sapiens_hsa051311.00961460
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.99951317
66Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.99143747
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.98177735
68Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.97567824
69Folate biosynthesis_Homo sapiens_hsa007900.97022569
70Jak-STAT signaling pathway_Homo sapiens_hsa046300.96842939
71Systemic lupus erythematosus_Homo sapiens_hsa053220.96349366
72PI3K-Akt signaling pathway_Homo sapiens_hsa041510.91818548
73Glutathione metabolism_Homo sapiens_hsa004800.88143753
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.87251819
75mRNA surveillance pathway_Homo sapiens_hsa030150.86924713
76Chronic myeloid leukemia_Homo sapiens_hsa052200.86778328
77Viral carcinogenesis_Homo sapiens_hsa052030.86504541
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.84760520
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.84505820
80Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.83856510
81Intestinal immune network for IgA production_Homo sapiens_hsa046720.81851521
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.81835870
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.79963148
84Influenza A_Homo sapiens_hsa051640.79519127
85Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.79036364
86Melanoma_Homo sapiens_hsa052180.77808292
87mTOR signaling pathway_Homo sapiens_hsa041500.77236462
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.76933906
89Herpes simplex infection_Homo sapiens_hsa051680.76642229
90RNA polymerase_Homo sapiens_hsa030200.76233237
91Hepatitis C_Homo sapiens_hsa051600.75610851
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.73404886
93Tight junction_Homo sapiens_hsa045300.72927652
94RNA degradation_Homo sapiens_hsa030180.68942911
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68158987
96Asthma_Homo sapiens_hsa053100.67453952
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63076935
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63016371
99Rap1 signaling pathway_Homo sapiens_hsa040150.62694060
100Proteasome_Homo sapiens_hsa030500.62246214
101Pentose phosphate pathway_Homo sapiens_hsa000300.62145266
102Apoptosis_Homo sapiens_hsa042100.61957888
103Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.61481445
104Platelet activation_Homo sapiens_hsa046110.60332659
105Vitamin digestion and absorption_Homo sapiens_hsa049770.59806249
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.58677807
107Prolactin signaling pathway_Homo sapiens_hsa049170.58082330
108Purine metabolism_Homo sapiens_hsa002300.57602868
109Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56474315
110Leishmaniasis_Homo sapiens_hsa051400.56189420
111Amoebiasis_Homo sapiens_hsa051460.55358840
112Endocytosis_Homo sapiens_hsa041440.55146545
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53758304
114Colorectal cancer_Homo sapiens_hsa052100.53223814
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.52025095
116Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51949496
117Tryptophan metabolism_Homo sapiens_hsa003800.51432456
118Ovarian steroidogenesis_Homo sapiens_hsa049130.51350391
119Prostate cancer_Homo sapiens_hsa052150.51165425
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.50509856
121Lysine degradation_Homo sapiens_hsa003100.50221012
122Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49721423
123Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48750038
124Rheumatoid arthritis_Homo sapiens_hsa053230.48628876
125Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48413727
126Prion diseases_Homo sapiens_hsa050200.48082298
127Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47874405
128Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47470937
129MAPK signaling pathway_Homo sapiens_hsa040100.47261016
130Malaria_Homo sapiens_hsa051440.46775647
131Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.46562133
132Chemokine signaling pathway_Homo sapiens_hsa040620.45719655
133Type I diabetes mellitus_Homo sapiens_hsa049400.45304925
134Tuberculosis_Homo sapiens_hsa051520.44661657
135Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43994289
136Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43770458
137Selenocompound metabolism_Homo sapiens_hsa004500.43386043
138Epstein-Barr virus infection_Homo sapiens_hsa051690.39828235
139Alcoholism_Homo sapiens_hsa050340.37891094
140N-Glycan biosynthesis_Homo sapiens_hsa005100.37333788
141Antigen processing and presentation_Homo sapiens_hsa046120.36139182
142Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.34781577
143Pertussis_Homo sapiens_hsa051330.33758137
144Steroid hormone biosynthesis_Homo sapiens_hsa001400.33697481
145Sphingolipid metabolism_Homo sapiens_hsa006000.33539599
146RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.33392400
147FoxO signaling pathway_Homo sapiens_hsa040680.32831711
148Salmonella infection_Homo sapiens_hsa051320.31448093
149Toxoplasmosis_Homo sapiens_hsa051450.31426550
150Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30682245
151Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.30329591
152Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29927468
153NF-kappa B signaling pathway_Homo sapiens_hsa040640.28448214

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