HOXB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXB genes located in a cluster on chromosome 17. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1phasic smooth muscle contraction (GO:0014821)6.49047303
2negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)5.84632637
3regulation of cellular amino acid metabolic process (GO:0006521)5.69370937
4* cranial nerve structural organization (GO:0021604)5.65510680
5ribosomal small subunit assembly (GO:0000028)5.63907932
6cellular response to estradiol stimulus (GO:0071392)5.46245725
7positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)5.39887235
8DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:005.36035273
9base-excision repair, AP site formation (GO:0006285)5.31921543
10intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)5.26189405
11signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)5.26189405
12signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)5.22395186
13signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)5.22395186
14signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)5.22395186
15negative regulation of ligase activity (GO:0051352)5.16839887
16negative regulation of ubiquitin-protein transferase activity (GO:0051444)5.16839887
17regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)5.15592611
18signal transduction involved in cell cycle checkpoint (GO:0072395)5.00668863
19signal transduction involved in DNA integrity checkpoint (GO:0072401)5.00633429
20signal transduction involved in DNA damage checkpoint (GO:0072422)5.00633429
21regulation of timing of cell differentiation (GO:0048505)4.99868977
22regulation of development, heterochronic (GO:0040034)4.97474964
23anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.95379438
24peptidyl-arginine omega-N-methylation (GO:0035247)4.94021240
25calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.85891793
26proteasome assembly (GO:0043248)4.80919688
27pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.72798744
28positive regulation of hair follicle development (GO:0051798)4.72133497
29positive regulation of hair cycle (GO:0042635)4.72133497
30negative regulation of activin receptor signaling pathway (GO:0032926)4.61509837
31blastocyst development (GO:0001824)4.58489525
32positive regulation of ubiquitin-protein transferase activity (GO:0051443)4.58272063
33regulation of hair follicle development (GO:0051797)4.55096751
34antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:4.48053641
35DNA deamination (GO:0045006)4.40578306
36positive regulation of ligase activity (GO:0051351)4.37523545
37histone arginine methylation (GO:0034969)4.30382230
38pyrimidine nucleotide catabolic process (GO:0006244)4.21179480
39platelet dense granule organization (GO:0060155)4.21104953
40peptidyl-arginine N-methylation (GO:0035246)4.16460344
41peptidyl-arginine methylation (GO:0018216)4.16460344
42organelle disassembly (GO:1903008)4.16048524
43antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)4.13537052
44lymphoid progenitor cell differentiation (GO:0002320)4.13024775
45respiratory chain complex IV assembly (GO:0008535)4.12167143
46* anatomical structure arrangement (GO:0048532)4.07621613
47definitive hemopoiesis (GO:0060216)4.05685956
48regulation of cellular amine metabolic process (GO:0033238)4.04705240
49response to interferon-beta (GO:0035456)4.02003176
50positive regulation of cell cycle arrest (GO:0071158)4.00264350
51regulation of ubiquitin-protein transferase activity (GO:0051438)3.89360868
52DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.88438414
53cellular response to estrogen stimulus (GO:0071391)3.81252864
54regulation of mitochondrial translation (GO:0070129)3.79159833
55regulation of ligase activity (GO:0051340)3.74935082
56daunorubicin metabolic process (GO:0044597)3.69368957
57polyketide metabolic process (GO:0030638)3.69368957
58doxorubicin metabolic process (GO:0044598)3.69368957
59protein deneddylation (GO:0000338)3.66953936
60negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)3.65687167
61negative regulation of cell cycle G1/S phase transition (GO:1902807)3.65687167
62cytochrome complex assembly (GO:0017004)3.64348205
63tRNA methylation (GO:0030488)3.63162596
64spliceosomal snRNP assembly (GO:0000387)3.59030631
65negative regulation of protein ubiquitination (GO:0031397)3.55103345
66viral transcription (GO:0019083)3.54493216
67paraxial mesoderm development (GO:0048339)3.53928457
68cranial nerve morphogenesis (GO:0021602)3.51026050
69purine ribonucleotide transport (GO:0015868)3.49772650
70regulation of cell cycle arrest (GO:0071156)3.48094605
71chaperone-mediated protein transport (GO:0072321)3.45757535
72negative regulation of protein modification by small protein conjugation or removal (GO:1903321)3.45087628
73G1/S transition of mitotic cell cycle (GO:0000082)3.43414734
74cell cycle G1/S phase transition (GO:0044843)3.43414734
75adenine nucleotide transport (GO:0051503)3.38073924
76signal transduction in response to DNA damage (GO:0042770)3.37616560
77nucleotide transmembrane transport (GO:1901679)3.37027891
78DNA replication initiation (GO:0006270)3.34943730
79negative regulation of viral genome replication (GO:0045071)3.34503513
80DNA strand elongation involved in DNA replication (GO:0006271)3.32802056
81translational termination (GO:0006415)3.32745387
82fat-soluble vitamin catabolic process (GO:0042363)3.29982311
83vitamin catabolic process (GO:0009111)3.29982311
84deoxyribonucleotide catabolic process (GO:0009264)3.27556859
85cullin deneddylation (GO:0010388)3.25097373
86GTP biosynthetic process (GO:0006183)3.23406596
87ribosomal small subunit biogenesis (GO:0042274)3.22517832
88maturation of SSU-rRNA (GO:0030490)3.21429422
89cranial nerve development (GO:0021545)3.19213298
90establishment of protein localization to mitochondrial membrane (GO:0090151)3.19069453
91mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.15797988
92cerebellum development (GO:0021549)3.13997088
93CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.13729387
94CTP biosynthetic process (GO:0006241)3.12502337
95CTP metabolic process (GO:0046036)3.12502337
96nucleoside transmembrane transport (GO:1901642)3.11589654
97ribonucleoside bisphosphate biosynthetic process (GO:0034030)3.10602870
98nucleoside bisphosphate biosynthetic process (GO:0033866)3.10602870
99purine nucleoside bisphosphate biosynthetic process (GO:0034033)3.10602870
100female gonad development (GO:0008585)3.10329661
101DNA strand elongation (GO:0022616)3.10132575
102outer ear morphogenesis (GO:0042473)3.09041298
103regulation of G1/S transition of mitotic cell cycle (GO:2000045)3.06634455
104spinal cord association neuron differentiation (GO:0021527)3.06606778
105SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.05887499
106double-strand break repair via nonhomologous end joining (GO:0006303)3.05597662
107non-recombinational repair (GO:0000726)3.05597662
108DNA damage response, detection of DNA damage (GO:0042769)3.04550161
109response to folic acid (GO:0051593)3.04104820
110regulation of cell cycle G1/S phase transition (GO:1902806)3.03841429
111mature B cell differentiation (GO:0002335)3.03496745
112base-excision repair (GO:0006284)3.02953538
113regulation of hair cycle (GO:0042634)3.02072169
114mesonephros development (GO:0001823)3.01359157
115cotranslational protein targeting to membrane (GO:0006613)3.00505489
116thyroid gland development (GO:0030878)2.99846898
117regulation of appetite (GO:0032098)2.99227124
118pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.98881818
119protein polyglutamylation (GO:0018095)2.97495151
120UTP biosynthetic process (GO:0006228)2.96781284
121protein targeting to ER (GO:0045047)2.95998379
122pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.93878737
123* facial nerve structural organization (GO:0021612)2.92037688
124antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.91983955
125pseudouridine synthesis (GO:0001522)2.91061165
126deoxyribose phosphate catabolic process (GO:0046386)2.89995120
127mature B cell differentiation involved in immune response (GO:0002313)2.89830707
128negative regulation of erythrocyte differentiation (GO:0045647)2.89382959
129DNA ligation (GO:0006266)2.87128159
130protein localization to endoplasmic reticulum (GO:0070972)2.86189714
131pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.85507834
132mannosylation (GO:0097502)2.84662613
133regulation of apoptotic process involved in morphogenesis (GO:1902337)2.82985945
134defense response to protozoan (GO:0042832)2.82263269
135response to interferon-alpha (GO:0035455)2.81147220
136deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.79901817
137RNA methylation (GO:0001510)2.79806898
138phospholipid scrambling (GO:0017121)2.79247476
139tRNA modification (GO:0006400)2.77418871
140establishment of protein localization to endoplasmic reticulum (GO:0072599)2.76248702
141megakaryocyte development (GO:0035855)2.74042304
142DNA replication checkpoint (GO:0000076)2.71869890
143mesenchymal cell differentiation involved in renal system development (GO:2001012)2.68359834
144mesenchymal cell differentiation involved in kidney development (GO:0072161)2.68359834
145translational elongation (GO:0006414)2.68343786
146regulation of non-canonical Wnt signaling pathway (GO:2000050)2.65547052
147postsynaptic membrane organization (GO:0001941)2.64747081
148negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.63987726
149negative regulation of T-helper cell differentiation (GO:0045623)2.63987726
150T cell lineage commitment (GO:0002360)2.61583802
151ribosomal large subunit biogenesis (GO:0042273)2.60746976
152telomere maintenance via semi-conservative replication (GO:0032201)2.60091257
153negative regulation of transcription by competitive promoter binding (GO:0010944)2.59301971
154exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.59149411
155viral life cycle (GO:0019058)2.58307430
156centriole assembly (GO:0098534)2.57826287
157regulation of pigment cell differentiation (GO:0050932)2.55710056
158termination of RNA polymerase III transcription (GO:0006386)2.55583333
159transcription elongation from RNA polymerase III promoter (GO:0006385)2.55583333
160positive regulation of T cell mediated cytotoxicity (GO:0001916)2.54997519
161secretory granule organization (GO:0033363)2.52968647
162GPI anchor biosynthetic process (GO:0006506)2.52855534
163DNA catabolic process, exonucleolytic (GO:0000738)2.46111453
164fucose catabolic process (GO:0019317)2.44461639
165L-fucose metabolic process (GO:0042354)2.44461639
166L-fucose catabolic process (GO:0042355)2.44461639
167presynaptic membrane assembly (GO:0097105)2.44075972
168response to protozoan (GO:0001562)2.43929644
169viral genome replication (GO:0019079)2.42456798
170cartilage morphogenesis (GO:0060536)2.41763816
171nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.40971907
172viral mRNA export from host cell nucleus (GO:0046784)2.40122234
173cellular protein complex disassembly (GO:0043624)2.39550526
174nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.39504384
175RNA capping (GO:0036260)2.38976844
1767-methylguanosine RNA capping (GO:0009452)2.38976844
177tRNA processing (GO:0008033)2.37419747
178endothelium development (GO:0003158)2.35049746
179intra-S DNA damage checkpoint (GO:0031573)2.34507829
180cellular response to interferon-beta (GO:0035458)2.34439328
181meiotic chromosome segregation (GO:0045132)2.34419821
182RNA modification (GO:0009451)2.33604396
183telomere maintenance via recombination (GO:0000722)2.33065658
1847-methylguanosine mRNA capping (GO:0006370)2.32435878
185response to peptidoglycan (GO:0032494)2.31446737
186omega-hydroxylase P450 pathway (GO:0097267)2.30582763
187short-term memory (GO:0007614)2.29923658
188negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.27730789
189reciprocal DNA recombination (GO:0035825)2.26938608
190reciprocal meiotic recombination (GO:0007131)2.26938608
191granulocyte differentiation (GO:0030851)2.26775431
192B cell differentiation (GO:0030183)2.26620527
193regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.26081541
194specification of organ identity (GO:0010092)2.25569595
195peristalsis (GO:0030432)11.2058152

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.72369574
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.87115329
3ELF1_17652178_ChIP-ChIP_JURKAT_Human3.41429286
4SCL_19346495_ChIP-Seq_HPC-7_Human3.24819285
5TP63_19390658_ChIP-ChIP_HaCaT_Human3.08642281
6BP1_19119308_ChIP-ChIP_Hs578T_Human2.88957659
7NOTCH1_21737748_ChIP-Seq_TLL_Human2.85968695
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.64171340
9* SOX2_18555785_ChIP-Seq_MESCs_Mouse2.57704411
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.57344559
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.55014481
12EZH2_22144423_ChIP-Seq_EOC_Human2.45919291
13LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.38775478
14PCGF2_27294783_Chip-Seq_ESCs_Mouse2.25786334
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.24141324
16FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.23108984
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.22613007
18E2F1_18555785_ChIP-Seq_MESCs_Mouse2.21376069
19E2F7_22180533_ChIP-Seq_HELA_Human2.17704723
20BMI1_23680149_ChIP-Seq_NPCS_Mouse2.15693579
21CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.15439310
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.13700106
23IRF1_19129219_ChIP-ChIP_H3396_Human2.10891785
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.09748578
25IRF8_22096565_ChIP-ChIP_GC-B_Human2.05203796
26CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.03992395
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.03933991
28MYC_18555785_ChIP-Seq_MESCs_Mouse2.00652724
29* SOX2_16153702_ChIP-ChIP_HESCs_Human1.99453592
30NELFA_20434984_ChIP-Seq_ESCs_Mouse1.99092661
31SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.98844759
32IGF1R_20145208_ChIP-Seq_DFB_Human1.95576086
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.91285671
34PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.90688889
35GBX2_23144817_ChIP-Seq_PC3_Human1.89502563
36RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.87232579
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.85965791
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.85867602
39JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.84605819
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.81129803
41IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.76499046
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.75674216
43* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.74726108
44CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.73534084
45* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.72250527
46NANOG_21062744_ChIP-ChIP_HESCs_Human1.72052194
47* NANOG_16153702_ChIP-ChIP_HESCs_Human1.70853021
48EST1_17652178_ChIP-ChIP_JURKAT_Human1.67530980
49ZFP57_27257070_Chip-Seq_ESCs_Mouse1.66575036
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.66508587
51MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.66102074
52CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.64523934
53GABP_17652178_ChIP-ChIP_JURKAT_Human1.64102048
54ERG_20887958_ChIP-Seq_HPC-7_Mouse1.64089908
55LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.63384860
56GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62856951
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.61553141
58MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.61476917
59RNF2_27304074_Chip-Seq_NSC_Mouse1.56234686
60GABP_19822575_ChIP-Seq_HepG2_Human1.52697652
61NFE2_27457419_Chip-Seq_LIVER_Mouse1.51493000
62VDR_23849224_ChIP-Seq_CD4+_Human1.49916818
63PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48757344
64MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.47923938
65SUZ12_27294783_Chip-Seq_NPCs_Mouse1.46443400
66* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.44576644
67FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.43997617
68TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.40633799
69MYC_18358816_ChIP-ChIP_MESCs_Mouse1.40093743
70E2F4_17652178_ChIP-ChIP_JURKAT_Human1.38662773
71ELK1_19687146_ChIP-ChIP_HELA_Human1.38077287
72DCP1A_22483619_ChIP-Seq_HELA_Human1.35736739
73FOXP3_21729870_ChIP-Seq_TREG_Human1.34742307
74* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.33385484
75VDR_22108803_ChIP-Seq_LS180_Human1.32560525
76JARID2_20064375_ChIP-Seq_MESCs_Mouse1.31361158
77ZFX_18555785_ChIP-Seq_MESCs_Mouse1.28767063
78CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.28697221
79STAT4_19710469_ChIP-ChIP_TH1__Mouse1.27793462
80YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27705181
81CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.26832672
82POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.26755028
83FUS_26573619_Chip-Seq_HEK293_Human1.26720151
84* MYC_18940864_ChIP-ChIP_HL60_Human1.25767241
85RBPJ_22232070_ChIP-Seq_NCS_Mouse1.24608021
86DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.24451408
87SPI1_23547873_ChIP-Seq_NB4_Human1.23989477
88ELK1_22589737_ChIP-Seq_MCF10A_Human1.22503098
89THAP11_20581084_ChIP-Seq_MESCs_Mouse1.22453031
90MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.22339607
91PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22223162
92MYCN_18555785_ChIP-Seq_MESCs_Mouse1.22024373
93KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.21967500
94LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21152000
95MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.20551090
96GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.19910774
97BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.19829827
98CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19605613
99ETS1_20019798_ChIP-Seq_JURKAT_Human1.19594139
100MYC_19079543_ChIP-ChIP_MESCs_Mouse1.19176969
101NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.18756266
102EZH2_27294783_Chip-Seq_NPCs_Mouse1.18080936
103KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.17802392
104KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.17802392
105KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.17802392
106PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16684017
107MYC_19030024_ChIP-ChIP_MESCs_Mouse1.16512549
108POU3F2_20337985_ChIP-ChIP_501MEL_Human1.16175580
109SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13141754
110EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.12156086
111STAT3_18555785_Chip-Seq_ESCs_Mouse1.11926496
112* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.11902153
113* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.11460589
114EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11259482
115IRF8_21731497_ChIP-ChIP_J774_Mouse1.10185845
116RUNX1_27457419_Chip-Seq_LIVER_Mouse1.10123376
117TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.09955833
118EWS_26573619_Chip-Seq_HEK293_Human1.09616900
119* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.09359626
120NMYC_18555785_Chip-Seq_ESCs_Mouse1.08518357
121* RING1B_27294783_Chip-Seq_ESCs_Mouse1.08310525
122P53_22387025_ChIP-Seq_ESCs_Mouse1.07987896
123SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07462225
124AR_21909140_ChIP-Seq_LNCAP_Human1.06280228
125P300_18555785_Chip-Seq_ESCs_Mouse1.05761966
126E2F1_21310950_ChIP-Seq_MCF-7_Human1.05640167
127STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.05260760
128* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.04979223
129TTF2_22483619_ChIP-Seq_HELA_Human1.04057567
130CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.03754901
131TAL1_26923725_Chip-Seq_HPCs_Mouse1.03386244
132XRN2_22483619_ChIP-Seq_HELA_Human1.03320410
133EZH2_27304074_Chip-Seq_ESCs_Mouse1.03268819
134FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.03147701
135GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01987052
136FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.01460040
137CREB1_15753290_ChIP-ChIP_HEK293T_Human1.01038624
138TAF15_26573619_Chip-Seq_HEK293_Human0.99683045
139CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.98258242
140KAP1_22055183_ChIP-Seq_ESCs_Mouse0.96001163
141ZFX_18555785_Chip-Seq_ESCs_Mouse0.95942407
142E2F1_18555785_Chip-Seq_ESCs_Mouse0.95879861
143SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.94735223
144YY1_21170310_ChIP-Seq_MESCs_Mouse0.94358688
145* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.93159524
146CIITA_25753668_ChIP-Seq_RAJI_Human0.91808631
147TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.91169872
148* EED_16625203_ChIP-ChIP_MESCs_Mouse0.90960741
149E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.90860759
150ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.90803041
151GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.90698189
152CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.90696803
153* EOMES_21245162_ChIP-Seq_HESCs_Human0.90270028
154JARID2_20075857_ChIP-Seq_MESCs_Mouse0.89964804
155CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.89935030
156FOXP1_21924763_ChIP-Seq_HESCs_Human0.87688939
157* SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.86494567

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005167_abnormal_blood-brain_barrier7.84301112
2MP0006292_abnormal_olfactory_placode4.59432338
3MP0003136_yellow_coat_color4.17141195
4MP0001188_hyperpigmentation3.98631634
5MP0008789_abnormal_olfactory_epithelium3.26114657
6MP0005451_abnormal_body_composition3.11902175
7MP0005409_darkened_coat_color2.98001374
8MP0009379_abnormal_foot_pigmentation2.87130446
9MP0002254_reproductive_system_inflammat2.81462525
10MP0005174_abnormal_tail_pigmentation2.81225372
11MP0003283_abnormal_digestive_organ2.80646999
12MP0004381_abnormal_hair_follicle2.77917152
13MP0005075_abnormal_melanosome_morpholog2.75668935
14MP0005394_taste/olfaction_phenotype2.69362152
15MP0005499_abnormal_olfactory_system2.69362152
16MP0003787_abnormal_imprinting2.61771980
17MP0002102_abnormal_ear_morphology2.59869905
18MP0001986_abnormal_taste_sensitivity2.41536156
19MP0002249_abnormal_larynx_morphology2.33238787
20MP0001835_abnormal_antigen_presentation2.32024407
21MP0000372_irregular_coat_pigmentation2.29203792
22MP0000015_abnormal_ear_pigmentation2.24672778
23MP0003878_abnormal_ear_physiology2.13460654
24MP0005377_hearing/vestibular/ear_phenot2.13460654
25MP0009697_abnormal_copulation2.01938052
26MP0004133_heterotaxia1.98462597
27MP0003724_increased_susceptibility_to1.95943004
28MP0000049_abnormal_middle_ear1.91946699
29MP0001727_abnormal_embryo_implantation1.90916456
30MP0009785_altered_susceptibility_to1.84576057
31MP0008058_abnormal_DNA_repair1.83595326
32MP0002095_abnormal_skin_pigmentation1.83268181
33MP0005253_abnormal_eye_physiology1.78336273
34* MP0004924_abnormal_behavior1.76290060
35* MP0005386_behavior/neurological_phenoty1.76290060
36MP0005671_abnormal_response_to1.75942843
37MP0000343_altered_response_to1.75794619
38MP0003119_abnormal_digestive_system1.75776024
39MP0001529_abnormal_vocalization1.75338630
40MP0002233_abnormal_nose_morphology1.74866352
41MP0002653_abnormal_ependyma_morphology1.74129370
42MP0006054_spinal_hemorrhage1.70250362
43MP0000566_synostosis1.65744166
44MP0003718_maternal_effect1.64351585
45MP0005645_abnormal_hypothalamus_physiol1.62893434
46MP0002148_abnormal_hypersensitivity_rea1.62569041
47MP0002396_abnormal_hematopoietic_system1.61965219
48MP0002938_white_spotting1.56073773
49MP0002822_catalepsy1.53391252
50MP0010030_abnormal_orbit_morphology1.52345456
51MP0000681_abnormal_thyroid_gland1.49835257
52MP0004147_increased_porphyrin_level1.49820670
53MP0000678_abnormal_parathyroid_gland1.49348261
54MP0002177_abnormal_outer_ear1.48850841
55MP0000490_abnormal_crypts_of1.46221069
56MP0003315_abnormal_perineum_morphology1.45770522
57MP0003938_abnormal_ear_development1.44625262
58MP0000685_abnormal_immune_system1.43798291
59MP0001346_abnormal_lacrimal_gland1.42712116
60MP0004957_abnormal_blastocyst_morpholog1.40206586
61MP0004808_abnormal_hematopoietic_stem1.40189832
62MP0008877_abnormal_DNA_methylation1.37012035
63MP0002132_abnormal_respiratory_system1.36912957
64MP0001730_embryonic_growth_arrest1.36636518
65MP0005171_absent_coat_pigmentation1.35532493
66MP0005248_abnormal_Harderian_gland1.32042016
67MP0005025_abnormal_response_to1.30485789
68MP0002277_abnormal_respiratory_mucosa1.28155543
69MP0002734_abnormal_mechanical_nocicepti1.25881144
70MP0008260_abnormal_autophagy1.23653283
71MP0003763_abnormal_thymus_physiology1.22038691
72MP0001853_heart_inflammation1.19884674
73* MP0000428_abnormal_craniofacial_morphol1.18443112
74MP0004142_abnormal_muscle_tone1.18154313
75MP0002638_abnormal_pupillary_reflex1.14251750
76MP0001800_abnormal_humoral_immune1.12116799
77* MP0002752_abnormal_somatic_nervous1.10732383
78MP0008007_abnormal_cellular_replicative1.10601347
79MP0002876_abnormal_thyroid_physiology1.09937646
80MP0002723_abnormal_immune_serum1.09903797
81MP0002452_abnormal_antigen_presenting1.09319957
82MP0002009_preneoplasia1.07744240
83MP0003121_genomic_imprinting1.06765729
84MP0005397_hematopoietic_system_phenotyp1.06619095
85MP0001545_abnormal_hematopoietic_system1.06619095
86MP0003880_abnormal_central_pattern1.06452830
87MP0000465_gastrointestinal_hemorrhage1.05259339
88MP0002932_abnormal_joint_morphology1.05057458
89MP0005000_abnormal_immune_tolerance1.04767980
90MP0002420_abnormal_adaptive_immunity1.04598970
91MP0001819_abnormal_immune_cell1.04579027
92MP0003111_abnormal_nucleus_morphology1.03447833
93MP0002160_abnormal_reproductive_system1.02910730
94MP0003646_muscle_fatigue1.01821525
95MP0003077_abnormal_cell_cycle1.01813666
96MP0009333_abnormal_splenocyte_physiolog1.01101651
97MP0006072_abnormal_retinal_apoptosis1.00928554
98MP0002111_abnormal_tail_morphology1.00910215
99MP0002419_abnormal_innate_immunity0.99175545
100MP0005464_abnormal_platelet_physiology0.98277539
101MP0002398_abnormal_bone_marrow0.97147990
102MP0003786_premature_aging0.95786729
103MP0003567_abnormal_fetal_cardiomyocyte0.95730857
104MP0005646_abnormal_pituitary_gland0.93978219
105MP0005391_vision/eye_phenotype0.93778612
106MP0002557_abnormal_social/conspecific_i0.92495043
107MP0008057_abnormal_DNA_replication0.92030509
108MP0001299_abnormal_eye_distance/0.90885663
109MP0000026_abnormal_inner_ear0.90250237
110MP0001873_stomach_inflammation0.88804547
111MP0002163_abnormal_gland_morphology0.88570625
112MP0000537_abnormal_urethra_morphology0.87840802
113MP0009672_abnormal_birth_weight0.87693058
114MP0000689_abnormal_spleen_morphology0.87130080
115MP0001293_anophthalmia0.86261690
116MP0000716_abnormal_immune_system0.85773722
117MP0003937_abnormal_limbs/digits/tail_de0.83877806
118MP0002272_abnormal_nervous_system0.83641696
119MP0009250_abnormal_appendicular_skeleto0.83392962
120MP0000751_myopathy0.83139076
121MP0008932_abnormal_embryonic_tissue0.83111254
122MP0005623_abnormal_meninges_morphology0.81318938
123MP0010094_abnormal_chromosome_stability0.80915552
124MP0002085_abnormal_embryonic_tissue0.80828533
125MP0002722_abnormal_immune_system0.80596032
126MP0001919_abnormal_reproductive_system0.80418983
127MP0002751_abnormal_autonomic_nervous0.80202227
128MP0001905_abnormal_dopamine_level0.80200512
129MP0003861_abnormal_nervous_system0.79845886
130MP0003693_abnormal_embryo_hatching0.78126152
131MP0003935_abnormal_craniofacial_develop0.77357834
132MP0003385_abnormal_body_wall0.77263115
133MP0003755_abnormal_palate_morphology0.76921207
134MP0008995_early_reproductive_senescence0.76521116
135MP0003943_abnormal_hepatobiliary_system0.76489355
136* MP0001486_abnormal_startle_reflex0.75819972
137MP0001963_abnormal_hearing_physiology0.75479360
138MP0002089_abnormal_postnatal_growth/wei0.75393130
139MP0005083_abnormal_biliary_tract0.75283032
140MP0005387_immune_system_phenotype0.75136788
141MP0001790_abnormal_immune_system0.75136788
142MP0003866_abnormal_defecation0.73923959
143MP0001485_abnormal_pinna_reflex0.73862580
144MP0002429_abnormal_blood_cell0.73638079
145* MP0000432_abnormal_head_morphology0.73254292
146MP0005195_abnormal_posterior_eye0.73211820
147MP0002114_abnormal_axial_skeleton0.73089472
148MP0001119_abnormal_female_reproductive0.72617393
149MP0009046_muscle_twitch0.72399332
150MP0000631_abnormal_neuroendocrine_gland0.72291031
151MP0002210_abnormal_sex_determination0.71645843
152MP0004859_abnormal_synaptic_plasticity0.71068610
153MP0001984_abnormal_olfaction0.70729319
154MP0003011_delayed_dark_adaptation0.70580271
155MP0002084_abnormal_developmental_patter0.70554774
156MP0004215_abnormal_myocardial_fiber0.69645253
157MP0002282_abnormal_trachea_morphology0.68661071
158MP0003941_abnormal_skin_development0.68520083
159MP0001663_abnormal_digestive_system0.68476486
160MP0002075_abnormal_coat/hair_pigmentati0.67216406
161MP0001348_abnormal_lacrimal_gland0.67038993
162MP0000955_abnormal_spinal_cord0.66996231
163MP0005389_reproductive_system_phenotype0.66882068
164MP0005084_abnormal_gallbladder_morpholo0.66650357
165MP0010368_abnormal_lymphatic_system0.65487143
166MP0003122_maternal_imprinting0.62087069
167MP0000163_abnormal_cartilage_morphology0.58819258
168MP0000762_abnormal_tongue_morphology0.58331571
169MP0002184_abnormal_innervation0.57988527
170MP0003633_abnormal_nervous_system0.57045485

Predicted human phenotypes

RankGene SetZ-score
1Facial cleft (HP:0002006)6.35852960
2Type I transferrin isoform profile (HP:0003642)4.36040612
3Reduced antithrombin III activity (HP:0001976)3.82046653
4Type 2 muscle fiber atrophy (HP:0003554)3.78003198
5Birth length less than 3rd percentile (HP:0003561)3.71125095
6Absent eyebrow (HP:0002223)3.68700430
7Myelomeningocele (HP:0002475)3.63586010
8Abnormality of the axillary hair (HP:0100134)3.58770725
9Abnormality of secondary sexual hair (HP:0009888)3.58770725
10Proximal placement of thumb (HP:0009623)3.58747973
113-Methylglutaconic aciduria (HP:0003535)3.53042705
12Abnormal number of erythroid precursors (HP:0012131)3.52032699
13Aplasia/Hypoplasia of the sternum (HP:0006714)3.51577516
14Abnormality of cells of the erythroid lineage (HP:0012130)3.42341355
15Vaginal atresia (HP:0000148)3.39693994
16Morphological abnormality of the middle ear (HP:0008609)3.33956248
17Muscle fiber atrophy (HP:0100295)3.32679704
18Abnormality of the labia minora (HP:0012880)3.32589518
19Chromosomal breakage induced by crosslinking agents (HP:0003221)3.25433945
20Aplastic anemia (HP:0001915)3.21545674
21Genital tract atresia (HP:0001827)3.19834774
22Anophthalmia (HP:0000528)3.10326137
23Supernumerary spleens (HP:0009799)3.08779697
24Abnormality of the pubic bones (HP:0003172)3.06694305
25Bilateral microphthalmos (HP:0007633)3.05792457
26Abnormality of macular pigmentation (HP:0008002)3.05178421
27Deviation of the thumb (HP:0009603)3.02148197
28Stenosis of the external auditory canal (HP:0000402)2.99208715
29Meningocele (HP:0002435)2.97425544
30Methylmalonic aciduria (HP:0012120)2.94671698
31Chromsome breakage (HP:0040012)2.94213011
32Labial hypoplasia (HP:0000066)2.90571799
33Abnormal protein glycosylation (HP:0012346)2.88795620
34Abnormal glycosylation (HP:0012345)2.88795620
35Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.88795620
36Abnormal protein N-linked glycosylation (HP:0012347)2.88795620
37Reticulocytopenia (HP:0001896)2.85162259
38Cutaneous finger syndactyly (HP:0010554)2.82626737
39Abnormal number of incisors (HP:0011064)2.81921930
40Mixed hearing impairment (HP:0000410)2.80845530
41Patchy hypopigmentation of hair (HP:0011365)2.80004622
42* Nonprogressive disorder (HP:0003680)2.77637052
43Asplenia (HP:0001746)2.76944270
44Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.75677552
45Hypoplastic female external genitalia (HP:0012815)2.74865578
46Colon cancer (HP:0003003)2.74269761
47Cutaneous syndactyly (HP:0012725)2.72921649
48Absent rod-and cone-mediated responses on ERG (HP:0007688)2.71919932
49Absent hair (HP:0002298)2.71602047
50Bifid tongue (HP:0010297)2.71183671
51True hermaphroditism (HP:0010459)2.67626026
52Aplasia/Hypoplasia of the spleen (HP:0010451)2.66069661
53Bicornuate uterus (HP:0000813)2.62571046
54Dyschromatopsia (HP:0007641)2.61943056
55Dry hair (HP:0011359)2.61380530
56Thyroid-stimulating hormone excess (HP:0002925)2.61057457
57Thoracolumbar scoliosis (HP:0002944)2.60423453
58Abnormality of the lacrimal duct (HP:0011481)2.59587755
59Selective tooth agenesis (HP:0001592)2.55489648
60Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.54049987
61Choanal stenosis (HP:0000452)2.50116879
62Glossoptosis (HP:0000162)2.46534366
63Microvesicular hepatic steatosis (HP:0001414)2.43208294
64Congenital primary aphakia (HP:0007707)2.41136498
65Microretrognathia (HP:0000308)2.41036253
66Aplasia/Hypoplasia of the sacrum (HP:0008517)2.40227449
67Mesomelia (HP:0003027)2.40205641
68Hypoplasia of the thymus (HP:0000778)2.39325939
69Abnormal lung lobation (HP:0002101)2.38465873
70Meckel diverticulum (HP:0002245)2.37726943
71White forelock (HP:0002211)2.37323938
72Renal Fanconi syndrome (HP:0001994)2.34571149
73Abnormality of the lumbar spine (HP:0100712)2.34513071
74Cerebral hypomyelination (HP:0006808)2.33977585
75Gait imbalance (HP:0002141)2.33901795
76Hypoplastic labia majora (HP:0000059)2.33074702
77Disproportionate short-trunk short stature (HP:0003521)2.32052234
78Increased hepatocellular lipid droplets (HP:0006565)2.30934948
79Hypothermia (HP:0002045)2.30810039
80Abnormality of the prostate (HP:0008775)2.26889761
81Cleft eyelid (HP:0000625)2.26209884
82Prolonged bleeding time (HP:0003010)2.26095368
83Abnormality of the ileum (HP:0001549)2.23016326
84Abnormality of the heme biosynthetic pathway (HP:0010472)2.22521289
85Abdominal situs inversus (HP:0003363)2.20151639
86Abnormality of abdominal situs (HP:0011620)2.20151639
87Median cleft lip (HP:0000161)2.19155352
88Vitreoretinal degeneration (HP:0000655)2.19023162
89Intestinal atresia (HP:0011100)2.18849499
90Clubbing of toes (HP:0100760)2.18523638
91Petechiae (HP:0000967)2.18324071
92Ectopic anus (HP:0004397)2.15764772
93Weak cry (HP:0001612)2.15239729
94Medial flaring of the eyebrow (HP:0010747)2.14720110
95Sex reversal (HP:0012245)2.12257146
96Abnormal sex determination (HP:0012244)2.12257146
97Abnormality of the preputium (HP:0100587)2.11739100
98Abnormal ciliary motility (HP:0012262)2.10501469
99Pallor (HP:0000980)2.07771219
100Abnormality of the phalanges of the hallux (HP:0010057)2.07727750
101Acute necrotizing encephalopathy (HP:0006965)2.07321316
102Abnormality of the labia majora (HP:0012881)2.06862174
103Abnormality of the nasolacrimal system (HP:0000614)2.06060009
104Abnormality of the columella (HP:0009929)2.05265246
105Abnormal respiratory motile cilium morphology (HP:0005938)2.03857123
106Abnormal respiratory epithelium morphology (HP:0012253)2.03857123
107Hepatocellular necrosis (HP:0001404)2.03591670
108Aplasia/Hypoplasia of the uvula (HP:0010293)2.02938014
109Synostosis of carpal bones (HP:0005048)2.02379665
110Hemivertebrae (HP:0002937)2.01968463
111Cellular immunodeficiency (HP:0005374)2.01624106
112Abnormality of the labia (HP:0000058)2.01076828
113Nephrogenic diabetes insipidus (HP:0009806)2.00600211
114Omphalocele (HP:0001539)2.00149575
115Myositis (HP:0100614)1.99845994
116Meningitis (HP:0001287)1.99166123
117Acute encephalopathy (HP:0006846)1.98678601
118Chin dimple (HP:0010751)1.98129240
119Attenuation of retinal blood vessels (HP:0007843)1.97901557
120Nephronophthisis (HP:0000090)1.96352938
121Beaking of vertebral bodies (HP:0004568)1.96216461
122Thrombocytosis (HP:0001894)1.95947243
123High anterior hairline (HP:0009890)1.95517949
124Exertional dyspnea (HP:0002875)1.95196646
125Abnormality of the phalanges of the 2nd finger (HP:0009541)1.94580705
126Severe visual impairment (HP:0001141)1.94074275
127Broad foot (HP:0001769)1.93354701
128Abnormality of the pulmonary veins (HP:0011718)1.93187728
129Abnormal biliary tract physiology (HP:0012439)1.92707366
130Bile duct proliferation (HP:0001408)1.92707366
131Midline defect of the nose (HP:0004122)1.92423112
132Triphalangeal thumb (HP:0001199)1.92001639
133Cupped ear (HP:0000378)1.91928315
134Absent eyelashes (HP:0000561)1.91654263
135Short tibia (HP:0005736)1.90303460
136Medulloblastoma (HP:0002885)1.89786620
137Dynein arm defect of respiratory motile cilia (HP:0012255)1.89381440
138Absent/shortened dynein arms (HP:0200106)1.89381440
139Rhabdomyosarcoma (HP:0002859)1.88308832
140Optic nerve hypoplasia (HP:0000609)1.87914178
141Macrocytic anemia (HP:0001972)1.87249408
142Abnormality of the parietal bone (HP:0002696)1.87023413
143Pancreatic fibrosis (HP:0100732)1.86928247
144Broad thumb (HP:0011304)1.86004947
145Broad metatarsal (HP:0001783)1.85959789
146Facial diplegia (HP:0001349)1.85229960
147Lipid accumulation in hepatocytes (HP:0006561)1.85201617
148Horseshoe kidney (HP:0000085)1.84181175
149Partial duplication of the phalanx of hand (HP:0009999)1.83329988
150Central scotoma (HP:0000603)1.82418286
151Mediastinal lymphadenopathy (HP:0100721)1.82286136
152Short middle phalanx of the 5th finger (HP:0004220)1.82215666
153Pancytopenia (HP:0001876)1.81435679
154Anomalous pulmonary venous return (HP:0010772)1.80858217
155Pigmentary retinal degeneration (HP:0001146)1.80840782
156Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.80784174
157Retrobulbar optic neuritis (HP:0100654)1.80513559
158Optic neuritis (HP:0100653)1.80513559
159Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.80312172
160Mitochondrial inheritance (HP:0001427)1.79787463
161Rib fusion (HP:0000902)1.79333310
162Prostate neoplasm (HP:0100787)1.77854523
163Partial duplication of thumb phalanx (HP:0009944)1.77421971
164Thoracic kyphosis (HP:0002942)1.77401489
165Microtia (HP:0008551)1.77172000
166Renal hypoplasia (HP:0000089)1.76860262
167Abnormality of DNA repair (HP:0003254)1.76556898
168Preaxial hand polydactyly (HP:0001177)1.75763403
169Agammaglobulinemia (HP:0004432)1.75306775
170Epistaxis (HP:0000421)1.74897011
171Recurrent abscess formation (HP:0002722)1.74172899
172IgM deficiency (HP:0002850)1.73274393
173Myelodysplasia (HP:0002863)1.73011158
174Optic disc pallor (HP:0000543)1.72629076
175Obstructive lung disease (HP:0006536)1.71672080
176Chronic obstructive pulmonary disease (HP:0006510)1.71672080
177Abnormality of chromosome stability (HP:0003220)1.71031468
178Abnormal rod and cone electroretinograms (HP:0008323)1.70920523
179Pancreatic cysts (HP:0001737)1.70286158
180Hypergonadotropic hypogonadism (HP:0000815)1.69544557

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MUSK6.34838615
2CASK4.75670955
3MAP3K44.58573079
4EPHA44.38098737
5MKNK23.98765587
6TNIK3.34171933
7MKNK13.27615474
8STK163.21899349
9SRPK12.66989532
10NME22.55197915
11TLK12.54336835
12TXK2.10676640
13IRAK42.08111552
14CDK192.05122657
15MAP2K41.85924675
16BRD41.82253943
17MAP4K21.76552100
18TEC1.76292985
19IRAK31.66675077
20NLK1.59742927
21CSNK1A1L1.56070604
22KIT1.52350270
23STK38L1.52304770
24STK241.48632831
25VRK11.47149161
26ADRBK21.45347785
27GRK11.39621637
28CSNK1G21.36842000
29TIE11.35309918
30NME11.34301591
31CDC71.31126844
32PRKG21.23010563
33YES11.21980371
34EIF2AK21.21540412
35MAP3K121.18362720
36BTK1.18055461
37MAP2K71.14178112
38PLK21.11971380
39TGFBR21.06410815
40CDK81.06353801
41BLK1.05749732
42MAP4K11.05524020
43CLK11.04025891
44IKBKB1.03949691
45PLK41.03547291
46MAP3K141.02620348
47MAPKAPK50.99102277
48CDK30.96084584
49IKBKE0.95777063
50ZAK0.90813711
51NEK60.90595556
52PRPF4B0.90592836
53BMPR1B0.89648030
54CAMKK20.86629138
55VRK20.84895183
56PRKD20.84505630
57PLK30.84368056
58BCR0.83234899
59IRAK10.83090990
60IRAK20.82894662
61BRSK10.81708853
62EIF2AK30.81432994
63GRK70.80346871
64CSNK1G10.79775475
65CDK70.77984479
66DYRK30.76871091
67BCKDK0.76096693
68PIM20.75589609
69PIM10.70602195
70TGFBR10.68220832
71MAPK130.66567769
72RPS6KA50.66283367
73CDK120.65356345
74EIF2AK10.64999328
75LYN0.64157549
76BMPR20.63018669
77MAP2K60.62843720
78BMX0.62756181
79CDK90.62042668
80CAMK10.61744561
81TRIM280.60044999
82MYLK0.59840167
83PLK10.59461395
84SYK0.59012133
85DAPK10.58831967
86NTRK30.56098028
87TNK20.54029369
88MST40.53217411
89PINK10.52133813
90MATK0.51737897
91FLT30.51512686
92CSF1R0.51165917
93TESK10.51149203
94CHEK20.48096229
95FES0.48012275
96TAOK20.47377561
97PAK40.47276672
98PBK0.46401265
99TESK20.46238244
100KDR0.44291922
101PIK3CG0.44129727
102EPHB20.43632213
103BRSK20.42609074
104UHMK10.40742578
105CDK60.40081974
106FER0.40071828
107PDK20.39679213
108JAK30.38518662
109WEE10.38362504
110ERBB30.37650985
111CSNK2A10.36974177
112INSRR0.36497195
113BUB10.35106455
114CHUK0.34792667
115MAPK40.34093767
116DYRK1B0.34025852
117WNK30.33953691
118CHEK10.33589013
119CSNK1G30.32422622
120ATM0.32380192
121RPS6KA40.32372214
122LCK0.32045230
123TTK0.32012961
124TBK10.31659267
125SGK20.30355770
126MAPK110.29976413
127EGFR0.28593905
128RPS6KB10.28551206
129LIMK10.28528254
130FGFR20.28369332
131ATR0.27262297
132HIPK20.26507791
133RPS6KA60.26221728
134NEK20.26176848
135MAP3K50.25422305
136MAP2K30.25305516
137ZAP700.24455953
138DYRK1A0.24285600
139AKT30.23871455
140ACVR1B0.23835748
141RPS6KC10.23673128
142RPS6KL10.23673128
143DYRK20.23367662
144DAPK20.22139942
145CAMK1D0.22057980
146CDK50.22003074
147NEK90.22000794
148CAMK40.21964263
149NUAK10.21784325
150PIK3CA0.20282711
151CDK140.19982099
152CSNK2A20.19723829
153CDK20.16604121
154MAPK90.16473059
155MINK10.16116020
156CSNK1A10.14568164
157CSK0.14239905
158STK30.12655845
159CDK180.12646562
160AURKA0.12585122
161CSNK1E0.12494617
162MAPK100.11501935
163ERBB20.10359543
164ABL20.10162740
165MAP3K60.09814643
166CDK150.09702768
167PTK60.09694077
168CDK10.09069659
169EPHA20.08937462
170CDK11A0.08784879

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.06450466
2DNA replication_Homo sapiens_hsa030303.05763411
3RNA polymerase_Homo sapiens_hsa030202.69684227
4Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.60483989
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.51058877
6Homologous recombination_Homo sapiens_hsa034402.49641136
7Fanconi anemia pathway_Homo sapiens_hsa034602.42697546
8Mismatch repair_Homo sapiens_hsa034302.21601538
9Base excision repair_Homo sapiens_hsa034102.21000976
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.10285919
11Basal transcription factors_Homo sapiens_hsa030222.04345235
12Protein export_Homo sapiens_hsa030602.01974439
13Pyrimidine metabolism_Homo sapiens_hsa002401.99585891
14Spliceosome_Homo sapiens_hsa030401.92613876
15Nucleotide excision repair_Homo sapiens_hsa034201.83859250
16Allograft rejection_Homo sapiens_hsa053301.62368183
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.55725155
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.52032584
19Purine metabolism_Homo sapiens_hsa002301.50626852
20Primary immunodeficiency_Homo sapiens_hsa053401.49123582
21Arachidonic acid metabolism_Homo sapiens_hsa005901.47481808
22SNARE interactions in vesicular transport_Homo sapiens_hsa041301.46064352
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.45588437
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.43636502
25RNA degradation_Homo sapiens_hsa030181.42284912
26Vitamin B6 metabolism_Homo sapiens_hsa007501.41667736
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.35069366
28Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.33442784
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.33310962
30Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.33234682
31Propanoate metabolism_Homo sapiens_hsa006401.32286384
32Sphingolipid metabolism_Homo sapiens_hsa006001.29037973
33Autoimmune thyroid disease_Homo sapiens_hsa053201.29018478
34Transcriptional misregulation in cancer_Homo sapiens_hsa052021.27600838
35Proteasome_Homo sapiens_hsa030501.23948980
36Intestinal immune network for IgA production_Homo sapiens_hsa046721.23833931
37Non-homologous end-joining_Homo sapiens_hsa034501.22983738
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.22245163
39Hedgehog signaling pathway_Homo sapiens_hsa043401.21208508
40Herpes simplex infection_Homo sapiens_hsa051681.21165900
41Hematopoietic cell lineage_Homo sapiens_hsa046401.19585952
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.14169649
43Pyruvate metabolism_Homo sapiens_hsa006201.12941577
44Graft-versus-host disease_Homo sapiens_hsa053321.12799451
45Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.11957326
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.11423415
47Other glycan degradation_Homo sapiens_hsa005111.08379453
48Cyanoamino acid metabolism_Homo sapiens_hsa004601.08194610
49Measles_Homo sapiens_hsa051621.07285244
50Cysteine and methionine metabolism_Homo sapiens_hsa002701.04574822
51Asthma_Homo sapiens_hsa053101.03864977
52Oxidative phosphorylation_Homo sapiens_hsa001900.99655538
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.99241147
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.96374242
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.96203946
56Jak-STAT signaling pathway_Homo sapiens_hsa046300.93526567
57Malaria_Homo sapiens_hsa051440.92854427
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.92168510
59Parkinsons disease_Homo sapiens_hsa050120.91400993
60NOD-like receptor signaling pathway_Homo sapiens_hsa046210.90815182
61* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.87233351
62Phototransduction_Homo sapiens_hsa047440.86796372
63Ether lipid metabolism_Homo sapiens_hsa005650.82787968
64Leishmaniasis_Homo sapiens_hsa051400.82175033
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82084409
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81879945
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.81243775
68Cell cycle_Homo sapiens_hsa041100.81198746
69TGF-beta signaling pathway_Homo sapiens_hsa043500.80638886
70Huntingtons disease_Homo sapiens_hsa050160.79180813
71One carbon pool by folate_Homo sapiens_hsa006700.77232509
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75485390
73Folate biosynthesis_Homo sapiens_hsa007900.74899814
74Systemic lupus erythematosus_Homo sapiens_hsa053220.73892033
75N-Glycan biosynthesis_Homo sapiens_hsa005100.72897281
76RNA transport_Homo sapiens_hsa030130.72471858
772-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.69404114
78Hippo signaling pathway_Homo sapiens_hsa043900.67711978
79Biosynthesis of amino acids_Homo sapiens_hsa012300.67567354
80p53 signaling pathway_Homo sapiens_hsa041150.67021005
81Galactose metabolism_Homo sapiens_hsa000520.66794319
82Gastric acid secretion_Homo sapiens_hsa049710.64046649
83Toll-like receptor signaling pathway_Homo sapiens_hsa046200.63969775
84Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.63321417
85African trypanosomiasis_Homo sapiens_hsa051430.63131707
86Basal cell carcinoma_Homo sapiens_hsa052170.62427999
87Retinol metabolism_Homo sapiens_hsa008300.62416057
88Carbon metabolism_Homo sapiens_hsa012000.61447298
89Fat digestion and absorption_Homo sapiens_hsa049750.61242138
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60501369
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58412377
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56168005
93Taste transduction_Homo sapiens_hsa047420.54823559
94Linoleic acid metabolism_Homo sapiens_hsa005910.54284009
95Rheumatoid arthritis_Homo sapiens_hsa053230.54093767
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53802728
97Tight junction_Homo sapiens_hsa045300.53333357
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53147078
99Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.52114533
100Alzheimers disease_Homo sapiens_hsa050100.51559469
101Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.48480414
102Sulfur metabolism_Homo sapiens_hsa009200.48458166
103Serotonergic synapse_Homo sapiens_hsa047260.48361369
104Sulfur relay system_Homo sapiens_hsa041220.47535433
105Fatty acid elongation_Homo sapiens_hsa000620.47419972
106Oocyte meiosis_Homo sapiens_hsa041140.46586325
107Acute myeloid leukemia_Homo sapiens_hsa052210.46494074
108Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.46459608
109Collecting duct acid secretion_Homo sapiens_hsa049660.44646690
110Arginine and proline metabolism_Homo sapiens_hsa003300.44525904
111Vitamin digestion and absorption_Homo sapiens_hsa049770.43581103
112Type I diabetes mellitus_Homo sapiens_hsa049400.43564434
113Regulation of autophagy_Homo sapiens_hsa041400.43537687
114B cell receptor signaling pathway_Homo sapiens_hsa046620.43198605
115Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42675941
116Pertussis_Homo sapiens_hsa051330.42606556
117mRNA surveillance pathway_Homo sapiens_hsa030150.42522396
118Wnt signaling pathway_Homo sapiens_hsa043100.42435606
119Notch signaling pathway_Homo sapiens_hsa043300.41930082
120Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41565150
121Peroxisome_Homo sapiens_hsa041460.41467274
122Influenza A_Homo sapiens_hsa051640.41047103
123Type II diabetes mellitus_Homo sapiens_hsa049300.41006758
124Platelet activation_Homo sapiens_hsa046110.40477744
125Ovarian steroidogenesis_Homo sapiens_hsa049130.39541087
126Metabolic pathways_Homo sapiens_hsa011000.39296249
127Selenocompound metabolism_Homo sapiens_hsa004500.39141129
128Hepatitis B_Homo sapiens_hsa051610.38721963
129Cardiac muscle contraction_Homo sapiens_hsa042600.38497988
130Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38462759
131Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37738777
132Olfactory transduction_Homo sapiens_hsa047400.36664647
133Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36019167
134Melanogenesis_Homo sapiens_hsa049160.35918034
135Alcoholism_Homo sapiens_hsa050340.35714183
136Antigen processing and presentation_Homo sapiens_hsa046120.34683168
137Epstein-Barr virus infection_Homo sapiens_hsa051690.30802843
138Synaptic vesicle cycle_Homo sapiens_hsa047210.30065633
139Histidine metabolism_Homo sapiens_hsa003400.28920762
140Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.28843488
141Thyroid cancer_Homo sapiens_hsa052160.27802258
142Lysine degradation_Homo sapiens_hsa003100.26459874
143Tryptophan metabolism_Homo sapiens_hsa003800.26256208
144Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.23762627
145beta-Alanine metabolism_Homo sapiens_hsa004100.22879393
146Glycosaminoglycan degradation_Homo sapiens_hsa005310.21777688
147Glutathione metabolism_Homo sapiens_hsa004800.21522827
148Fructose and mannose metabolism_Homo sapiens_hsa000510.20324749
149Steroid hormone biosynthesis_Homo sapiens_hsa001400.15060808
150Vibrio cholerae infection_Homo sapiens_hsa051100.14573651

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