HOXA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. The encoded protein may be involved in the placement of hindbrain segments in the proper location along the anterior-posterior axis during development. Two transcript variants encoding two different isoforms have been found for this gene, with only one of the isoforms containing the homeodomain region. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.34421298
2DNA unwinding involved in DNA replication (GO:0006268)4.84389641
3nuclear pore organization (GO:0006999)4.71089466
4paraxial mesoderm development (GO:0048339)4.62011613
5nuclear pore complex assembly (GO:0051292)4.52364728
6protein localization to kinetochore (GO:0034501)4.45790909
7pre-miRNA processing (GO:0031054)4.31195639
8regulation of gene silencing by RNA (GO:0060966)4.29449764
9regulation of posttranscriptional gene silencing (GO:0060147)4.29449764
10regulation of gene silencing by miRNA (GO:0060964)4.29449764
11polyamine biosynthetic process (GO:0006596)4.27829485
12mitotic nuclear envelope disassembly (GO:0007077)4.09709338
13mitotic metaphase plate congression (GO:0007080)4.02973601
14folic acid-containing compound biosynthetic process (GO:0009396)3.99300351
15regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.96947840
16natural killer cell mediated immunity (GO:0002228)3.95215959
17natural killer cell mediated cytotoxicity (GO:0042267)3.95215959
18hemidesmosome assembly (GO:0031581)3.87826505
19male meiosis I (GO:0007141)3.86889592
20regulation of mitotic spindle organization (GO:0060236)3.86048224
21membrane disassembly (GO:0030397)3.85619819
22nuclear envelope disassembly (GO:0051081)3.85619819
23DNA replication-dependent nucleosome organization (GO:0034723)3.84292695
24DNA replication-dependent nucleosome assembly (GO:0006335)3.84292695
25regulation of spindle organization (GO:0090224)3.81334327
26anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.78936355
27mitotic sister chromatid segregation (GO:0000070)3.65095812
28negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.63327243
29synaptonemal complex assembly (GO:0007130)3.60597252
30DNA replication checkpoint (GO:0000076)3.54970935
31DNA replication initiation (GO:0006270)3.51587487
32positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.51533695
33regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.51157292
34chromosome organization involved in meiosis (GO:0070192)3.50353758
35nucleobase biosynthetic process (GO:0046112)3.49820680
36meiosis I (GO:0007127)3.47699513
37ribosome assembly (GO:0042255)3.46785851
38pore complex assembly (GO:0046931)3.46408017
39negative regulation of ligase activity (GO:0051352)3.45718226
40negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.45718226
41sister chromatid segregation (GO:0000819)3.44328614
42synaptonemal complex organization (GO:0070193)3.43973299
43protein localization to chromosome, centromeric region (GO:0071459)3.43737383
44maturation of SSU-rRNA (GO:0030490)3.42456551
45metaphase plate congression (GO:0051310)3.41875009
46regulation of mitochondrial translation (GO:0070129)3.39784257
47telomere maintenance via semi-conservative replication (GO:0032201)3.39577466
48formation of translation preinitiation complex (GO:0001731)3.36973592
49heterochromatin organization (GO:0070828)3.36321579
50regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.36052368
51mitotic chromosome condensation (GO:0007076)3.35474221
52IMP biosynthetic process (GO:0006188)3.32327852
53peptidyl-arginine omega-N-methylation (GO:0035247)3.32191940
54deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.29247863
55DNA strand elongation involved in DNA replication (GO:0006271)3.29070895
56DNA synthesis involved in DNA repair (GO:0000731)3.27688667
57ventricular cardiac muscle cell development (GO:0055015)3.22888400
58peptidyl-histidine modification (GO:0018202)3.22400917
59negative regulation of chromosome segregation (GO:0051985)3.21095865
60synapsis (GO:0007129)3.17944578
61regulation of cellular amino acid metabolic process (GO:0006521)3.17514435
62translational termination (GO:0006415)3.13435600
63regulation of sister chromatid cohesion (GO:0007063)3.13343691
64negative regulation of mitotic sister chromatid separation (GO:2000816)3.12576983
65negative regulation of mitotic sister chromatid segregation (GO:0033048)3.12576983
66negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.12576983
67negative regulation of sister chromatid segregation (GO:0033046)3.12576983
68ribosomal large subunit biogenesis (GO:0042273)3.12336538
69polarized epithelial cell differentiation (GO:0030859)3.10550380
70mitotic spindle assembly checkpoint (GO:0007094)3.10037334
71viral transcription (GO:0019083)3.09260966
72positive regulation of SMAD protein import into nucleus (GO:0060391)3.09009071
73positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.08684515
74DNA strand elongation (GO:0022616)3.08459037
75kinetochore organization (GO:0051383)3.07812290
76spindle assembly checkpoint (GO:0071173)3.06660502
77positive regulation of hair cycle (GO:0042635)3.06535013
78positive regulation of hair follicle development (GO:0051798)3.06535013
79maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.05947885
80spliceosomal tri-snRNP complex assembly (GO:0000244)3.05417874
81positive regulation of chromosome segregation (GO:0051984)3.05344860
82establishment of apical/basal cell polarity (GO:0035089)3.05016496
83spindle checkpoint (GO:0031577)3.04427973
84mitotic spindle checkpoint (GO:0071174)3.03554842
85negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.02447912
86DNA geometric change (GO:0032392)3.00056198
87DNA duplex unwinding (GO:0032508)2.99381533
88nucleobase-containing small molecule interconversion (GO:0015949)2.99209964
89negative regulation of DNA repair (GO:0045738)2.98804769
90protein retention in ER lumen (GO:0006621)2.98230046
91histone arginine methylation (GO:0034969)2.97672438
92positive regulation of ligase activity (GO:0051351)2.97436543
93regulation of chromosome segregation (GO:0051983)2.96922951
94regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.96892553
95regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.96892553
96regulation of mitotic metaphase/anaphase transition (GO:0030071)2.96798357
97regulation of centrosome cycle (GO:0046605)2.96096805
98establishment of chromosome localization (GO:0051303)2.95184952
99regulation of ubiquitin-protein transferase activity (GO:0051438)2.93613098
100ribosomal small subunit assembly (GO:0000028)2.92960189
101histone H2A monoubiquitination (GO:0035518)2.92249917
102nuclear envelope organization (GO:0006998)2.91276215
103regulation of SMAD protein import into nucleus (GO:0060390)2.91268785
104regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.89329953
105IMP metabolic process (GO:0046040)2.88125425
106protein maturation by protein folding (GO:0022417)2.87447863
107protein localization to chromosome (GO:0034502)2.87109992
108translational elongation (GO:0006414)2.86897418
109translational initiation (GO:0006413)2.86767338
110positive regulation of cytokinesis (GO:0032467)2.86110336
111attachment of spindle microtubules to kinetochore (GO:0008608)2.85450687
112regulation of ligase activity (GO:0051340)2.84751337
113regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.84614557
114mitochondrial RNA metabolic process (GO:0000959)2.84402738
115lung-associated mesenchyme development (GO:0060484)2.83302681
116spliceosomal snRNP assembly (GO:0000387)2.82818627
117DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.82499838
118peptidyl-arginine methylation (GO:0018216)2.82261125
119peptidyl-arginine N-methylation (GO:0035246)2.82261125
120signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.81573663
121intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.81573663
122signal transduction involved in DNA damage checkpoint (GO:0072422)2.80493869
123signal transduction involved in DNA integrity checkpoint (GO:0072401)2.80493869
124cell cycle G1/S phase transition (GO:0044843)2.79453140
125G1/S transition of mitotic cell cycle (GO:0000082)2.79453140
126regulation of mitotic sister chromatid separation (GO:0010965)2.79038712
127regulation of mitotic sister chromatid segregation (GO:0033047)2.79038712
128regulation of sister chromatid segregation (GO:0033045)2.79038712
129regulation of telomere maintenance via telomerase (GO:0032210)2.78698901
130binding of sperm to zona pellucida (GO:0007339)2.78595459
131signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.78572264
132signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.78572264
133signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.78572264
134nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.78462862
135ribonucleoprotein complex biogenesis (GO:0022613)2.75745336
136meiotic nuclear division (GO:0007126)2.74210603
137snRNA metabolic process (GO:0016073)2.73023918
138telomere maintenance via recombination (GO:0000722)2.72638301
139regulation of cellular amine metabolic process (GO:0033238)2.71502890
140signal transduction involved in cell cycle checkpoint (GO:0072395)2.71000312
141ribosome biogenesis (GO:0042254)2.70565868
142positive regulation of cellular amine metabolic process (GO:0033240)2.70253234
143icosanoid secretion (GO:0032309)2.70132459
144arachidonic acid secretion (GO:0050482)2.70132459
145meiotic cell cycle process (GO:1903046)2.69769832
146chromatin assembly (GO:0031497)2.67678760
147regulation of hair follicle development (GO:0051797)2.66804090
148regulation of RNA export from nucleus (GO:0046831)2.66603486
149ribosomal small subunit biogenesis (GO:0042274)2.66190672
150* outer ear morphogenesis (GO:0042473)2.65204278
151negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.62992220
152notochord development (GO:0030903)2.62921102
153pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.62644271
154pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.62503041
155somatic hypermutation of immunoglobulin genes (GO:0016446)2.61834299
156somatic diversification of immune receptors via somatic mutation (GO:0002566)2.61834299
157piRNA metabolic process (GO:0034587)2.61821404
158histone-serine phosphorylation (GO:0035404)2.61779413
159positive regulation of mitotic sister chromatid separation (GO:1901970)2.60781340
160positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.60781340
161positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.60781340
162mitotic recombination (GO:0006312)2.60574478
163spliceosomal complex assembly (GO:0000245)2.60323721
164keratinocyte proliferation (GO:0043616)2.60282554
165establishment or maintenance of monopolar cell polarity (GO:0061339)2.59952150
166regulation of mammary gland epithelial cell proliferation (GO:0033599)2.58794077
167thyroid gland development (GO:0030878)2.56646461
168positive regulation of DNA-dependent DNA replication (GO:2000105)2.56492838

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.46804745
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.23575124
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.46852777
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.68614235
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.21930871
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.20193177
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.04506261
8MYC_19030024_ChIP-ChIP_MESCs_Mouse2.67564656
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.67062959
10NELFA_20434984_ChIP-Seq_ESCs_Mouse2.57018036
11AR_21909140_ChIP-Seq_LNCAP_Human2.50242666
12XRN2_22483619_ChIP-Seq_HELA_Human2.45526603
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.40808556
14KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.34534080
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.22253556
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.17198643
17SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.11297598
18MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.02135431
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.93249123
20EST1_17652178_ChIP-ChIP_JURKAT_Human1.91521578
21E2F1_18555785_ChIP-Seq_MESCs_Mouse1.91372126
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.90044885
23* NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.89067227
24ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.87222597
25POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.87095538
26* TTF2_22483619_ChIP-Seq_HELA_Human1.86465647
27E2F1_21310950_ChIP-Seq_MCF-7_Human1.83827071
28SOX2_18555785_ChIP-Seq_MESCs_Mouse1.83756783
29ETS1_20019798_ChIP-Seq_JURKAT_Human1.82861020
30KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.81131628
31KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.81131628
32KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.81131628
33SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.77605067
34MYCN_18555785_ChIP-Seq_MESCs_Mouse1.77015970
35TP63_19390658_ChIP-ChIP_HaCaT_Human1.74864908
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.74579805
37NANOG_18555785_ChIP-Seq_MESCs_Mouse1.74120589
38* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.70678364
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.70258306
40* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.67141470
41* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.65017551
42ZFX_18555785_ChIP-Seq_MESCs_Mouse1.57497763
43DCP1A_22483619_ChIP-Seq_HELA_Human1.54370292
44HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.54046684
45JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.53001284
46ELK1_19687146_ChIP-ChIP_HELA_Human1.52325041
47ESR1_15608294_ChIP-ChIP_MCF-7_Human1.51816460
48GABP_17652178_ChIP-ChIP_JURKAT_Human1.51670137
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.51559063
50HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.51287998
51POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.51047518
52FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.48783717
53KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.46016767
54MYC_22102868_ChIP-Seq_BL_Human1.45723531
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44995338
56NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.44565986
57TFEB_21752829_ChIP-Seq_HELA_Human1.39418818
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39229459
59CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.35096794
60* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.34799811
61SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.33256590
62* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32846539
63GABP_19822575_ChIP-Seq_HepG2_Human1.32683376
64TP63_17297297_ChIP-ChIP_HaCaT_Human1.31577324
65* HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.30458152
66* TET1_21451524_ChIP-Seq_MESCs_Mouse1.28840869
67ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.28375001
68FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.27939043
69VDR_23849224_ChIP-Seq_CD4+_Human1.27177708
70STAT3_1855785_ChIP-Seq_MESCs_Mouse1.25259820
71CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.23796632
72RBPJ_22232070_ChIP-Seq_NCS_Mouse1.23292370
73* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.21988379
74* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.19900970
75KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.19758774
76DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.18326017
77ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17926024
78KDM5A_27292631_Chip-Seq_BREAST_Human1.17912577
79CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.17760401
80* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17468323
81ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16130027
82* NANOG_16153702_ChIP-ChIP_HESCs_Human1.15221847
83NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.14844807
84ZNF263_19887448_ChIP-Seq_K562_Human1.14267968
85HOXB4_20404135_ChIP-ChIP_EML_Mouse1.14022278
86FOXP3_21729870_ChIP-Seq_TREG_Human1.13469527
87* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.12353036
88SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.12226850
89TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11034639
90TBX5_21415370_ChIP-Seq_HL-1_Mouse1.10601848
91EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.10354786
92NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.09993011
93TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.09840166
94PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.09265900
95CLOCK_20551151_ChIP-Seq_293T_Human1.08720310
96ATF3_27146783_Chip-Seq_COLON_Human1.07791022
97E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07606764
98HIF1A_21447827_ChIP-Seq_MCF-7_Human1.06372584
99SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.05131121
100RARG_19884340_ChIP-ChIP_MEFs_Mouse1.04886511
101TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.04683646
102* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.04667502
103* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.03678689
104NANOG_21062744_ChIP-ChIP_HESCs_Human1.02725128
105SOX17_20123909_ChIP-Seq_XEN_Mouse1.02709122
106SRF_21415370_ChIP-Seq_HL-1_Mouse1.02415702
107CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.02345612
108CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01287269
109E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.00980240
110SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00550949
111HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.99166396
112SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.98137738
113SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.98137738
114ELF1_17652178_ChIP-ChIP_JURKAT_Human0.97718887
115SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.97521106
116ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96767448
117* ELK3_25401928_ChIP-Seq_HUVEC_Human0.96523996
118* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.96500706
119TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.96481165
120* SOX2_16153702_ChIP-ChIP_HESCs_Human0.96439628
121* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.96283173
122* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.96132268
123SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95831236
124NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.95778672
125KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95376159
126SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.95288077
127TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94137297
128SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.91915354
129SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.91675465
130TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.90819370
131SRY_22984422_ChIP-ChIP_TESTIS_Rat0.87924508
132* YY1_21170310_ChIP-Seq_MESCs_Mouse0.86717134

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition6.02069017
2MP0010030_abnormal_orbit_morphology4.45443901
3MP0010352_gastrointestinal_tract_polyps3.01537672
4MP0003123_paternal_imprinting3.00163044
5MP0004957_abnormal_blastocyst_morpholog2.93960974
6MP0003111_abnormal_nucleus_morphology2.90136952
7MP0003693_abnormal_embryo_hatching2.86004075
8MP0005623_abnormal_meninges_morphology2.85462700
9MP0010094_abnormal_chromosome_stability2.82303264
10MP0003705_abnormal_hypodermis_morpholog2.82126880
11MP0003077_abnormal_cell_cycle2.75117922
12MP0002877_abnormal_melanocyte_morpholog2.43757558
13MP0002234_abnormal_pharynx_morphology2.37383109
14MP0000537_abnormal_urethra_morphology2.32783550
15MP0009053_abnormal_anal_canal2.30591052
16MP0008057_abnormal_DNA_replication2.24594520
17* MP0008932_abnormal_embryonic_tissue2.19413430
18MP0002796_impaired_skin_barrier2.17751186
19MP0001730_embryonic_growth_arrest2.14233398
20MP0000762_abnormal_tongue_morphology2.13742220
21MP0008438_abnormal_cutaneous_collagen2.13251423
22MP0002249_abnormal_larynx_morphology2.08034413
23MP0008007_abnormal_cellular_replicative2.05295227
24MP0003385_abnormal_body_wall2.03652155
25MP0010234_abnormal_vibrissa_follicle2.02555114
26MP0004197_abnormal_fetal_growth/weight/1.98777458
27MP0005501_abnormal_skin_physiology1.97314412
28MP0000579_abnormal_nail_morphology1.89482075
29MP0003786_premature_aging1.87123453
30MP0009697_abnormal_copulation1.77121655
31MP0000350_abnormal_cell_proliferation1.75850204
32* MP0000678_abnormal_parathyroid_gland1.74843010
33* MP0002085_abnormal_embryonic_tissue1.74759385
34MP0003121_genomic_imprinting1.74388049
35MP0005076_abnormal_cell_differentiation1.72269510
36MP0008058_abnormal_DNA_repair1.70230638
37MP0003937_abnormal_limbs/digits/tail_de1.70201247
38MP0003119_abnormal_digestive_system1.69313857
39MP0003941_abnormal_skin_development1.69281019
40MP0001672_abnormal_embryogenesis/_devel1.69228741
41MP0005380_embryogenesis_phenotype1.69228741
42MP0003566_abnormal_cell_adhesion1.68151426
43MP0005023_abnormal_wound_healing1.66315113
44MP0002084_abnormal_developmental_patter1.65987013
45MP0000467_abnormal_esophagus_morphology1.63217246
46MP0001697_abnormal_embryo_size1.63173114
47MP0002160_abnormal_reproductive_system1.61984343
48MP0002282_abnormal_trachea_morphology1.60956487
49MP0002932_abnormal_joint_morphology1.59896088
50MP0005248_abnormal_Harderian_gland1.58991345
51MP0002111_abnormal_tail_morphology1.57419693
52MP0009250_abnormal_appendicular_skeleto1.53885141
53MP0003984_embryonic_growth_retardation1.51753745
54MP0002088_abnormal_embryonic_growth/wei1.49761748
55MP0000733_abnormal_muscle_development1.48692681
56MP0010307_abnormal_tumor_latency1.46631601
57MP0001216_abnormal_epidermal_layer1.42476309
58MP0003122_maternal_imprinting1.40505114
59MP0004272_abnormal_basement_membrane1.37238174
60MP0000428_abnormal_craniofacial_morphol1.35873804
61MP0002080_prenatal_lethality1.35480665
62MP0002086_abnormal_extraembryonic_tissu1.35305718
63MP0002132_abnormal_respiratory_system1.34764924
64MP0004133_heterotaxia1.34745490
65MP0003567_abnormal_fetal_cardiomyocyte1.31330264
66MP0003453_abnormal_keratinocyte_physiol1.30876780
67MP0000516_abnormal_urinary_system1.27774541
68MP0005367_renal/urinary_system_phenotyp1.27774541
69MP0002210_abnormal_sex_determination1.27426509
70MP0002098_abnormal_vibrissa_morphology1.26084242
71MP0001915_intracranial_hemorrhage1.25110084
72MP0002653_abnormal_ependyma_morphology1.23826383
73MP0003115_abnormal_respiratory_system1.23215319
74MP0005503_abnormal_tendon_morphology1.22690663
75MP0002060_abnormal_skin_morphology1.20441709
76MP0003942_abnormal_urinary_system1.20370560
77* MP0003755_abnormal_palate_morphology1.19720609
78MP0010368_abnormal_lymphatic_system1.17521712
79MP0001293_anophthalmia1.17024930
80MP0005508_abnormal_skeleton_morphology1.15975699
81MP0003890_abnormal_embryonic-extraembry1.15953100
82MP0000566_synostosis1.14946595
83* MP0000049_abnormal_middle_ear1.14384451
84MP0003950_abnormal_plasma_membrane1.13309109
85MP0002114_abnormal_axial_skeleton1.13076550
86MP0001849_ear_inflammation1.10201071
87MP0004233_abnormal_muscle_weight1.08310397
88* MP0000432_abnormal_head_morphology1.06104044
89MP0000681_abnormal_thyroid_gland1.05661638
90* MP0003935_abnormal_craniofacial_develop1.03981109
91MP0001929_abnormal_gametogenesis1.03198878
92MP0001346_abnormal_lacrimal_gland1.01906609
93MP0002925_abnormal_cardiovascular_devel1.00043642
94MP0002938_white_spotting0.99497013
95MP0002697_abnormal_eye_size0.97019010
96MP0000358_abnormal_cell_content/0.96277516
97MP0005275_abnormal_skin_tensile0.96270818
98MP0010771_integument_phenotype0.96101612
99MP0000627_abnormal_mammary_gland0.95799351
100MP0005257_abnormal_intraocular_pressure0.94730600
101MP0003315_abnormal_perineum_morphology0.93769180
102* MP0002116_abnormal_craniofacial_bone0.93756019
103MP0001145_abnormal_male_reproductive0.90215269
104MP0000534_abnormal_ureter_morphology0.89841447
105MP0009672_abnormal_birth_weight0.85452333
106MP0003091_abnormal_cell_migration0.83647643
107MP0003806_abnormal_nucleotide_metabolis0.82547350
108MP0001286_abnormal_eye_development0.81894177
109MP0010678_abnormal_skin_adnexa0.80850692
110MP0000163_abnormal_cartilage_morphology0.80485721
111MP0009703_decreased_birth_body0.80311600
112* MP0003861_abnormal_nervous_system0.80060813
113* MP0002177_abnormal_outer_ear0.79201659
114MP0008789_abnormal_olfactory_epithelium0.79097111
115MP0002269_muscular_atrophy0.78164357
116MP0006054_spinal_hemorrhage0.77721383
117MP0000653_abnormal_sex_gland0.77423183
118MP0002092_abnormal_eye_morphology0.77135887
119MP0001614_abnormal_blood_vessel0.76980179
120MP0001243_abnormal_dermal_layer0.75628970
121MP0001661_extended_life_span0.74944500
122MP0003718_maternal_effect0.74072992
123MP0000313_abnormal_cell_death0.73824094
124MP0003283_abnormal_digestive_organ0.72655984
125MP0008260_abnormal_autophagy0.72273926
126MP0002233_abnormal_nose_morphology0.71520178
127MP0005621_abnormal_cell_physiology0.71406804
128MP0001340_abnormal_eyelid_morphology0.71048937
129MP0004185_abnormal_adipocyte_glucose0.70512847
130MP0003279_aneurysm0.70438235
131MP0000377_abnormal_hair_follicle0.70406438
132MP0009384_cardiac_valve_regurgitation0.70290003
133MP0005384_cellular_phenotype0.70223311
134MP0003699_abnormal_female_reproductive0.69742384
135MP0004782_abnormal_surfactant_physiolog0.69696635
136MP0005197_abnormal_uvea_morphology0.69628861
137MP0002081_perinatal_lethality0.69446433
138MP0005389_reproductive_system_phenotype0.69357105
139MP0003936_abnormal_reproductive_system0.68626796
140MP0009931_abnormal_skin_appearance0.66378482
141MP0003186_abnormal_redox_activity0.65243700
142MP0004858_abnormal_nervous_system0.65138181

Predicted human phenotypes

RankGene SetZ-score
1Short nail (HP:0001799)6.41038412
2Broad distal phalanx of finger (HP:0009836)5.88826289
311 pairs of ribs (HP:0000878)5.61735315
4Spinal cord compression (HP:0002176)4.67331902
5Radial bowing (HP:0002986)3.74252831
6Protrusio acetabuli (HP:0003179)3.58259305
7Fragile skin (HP:0001030)3.48153248
8Colon cancer (HP:0003003)3.26948031
9Selective tooth agenesis (HP:0001592)3.13107263
10Shallow orbits (HP:0000586)3.09616870
11Reticulocytopenia (HP:0001896)3.06398809
12Abnormality of carpal bone ossification (HP:0006257)3.03020521
13Popliteal pterygium (HP:0009756)2.94936651
14Fragile nails (HP:0001808)2.94554182
15Cupped ribs (HP:0000887)2.93144640
16Metaphyseal cupping (HP:0003021)2.90153927
17Truncus arteriosus (HP:0001660)2.90015202
18Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.88028819
19Short 4th metacarpal (HP:0010044)2.88028819
20Ankyloglossia (HP:0010296)2.83777573
21Premature rupture of membranes (HP:0001788)2.83262199
22Renal duplication (HP:0000075)2.83080354
23Rectovaginal fistula (HP:0000143)2.80301297
24Rectal fistula (HP:0100590)2.80301297
25Bowing of the arm (HP:0006488)2.72935024
26Bowed forearm bones (HP:0003956)2.72935024
27Microretrognathia (HP:0000308)2.72420785
28Ependymoma (HP:0002888)2.69709430
29Medulloblastoma (HP:0002885)2.68733411
30Hypokinesia (HP:0002375)2.67756720
31Abnormality of the umbilical cord (HP:0010881)2.66722403
32Onycholysis (HP:0001806)2.65645575
33Aplasia/Hypoplasia of the sacrum (HP:0008517)2.62790641
34Abnormal lung lobation (HP:0002101)2.61872049
35Stenosis of the external auditory canal (HP:0000402)2.53261377
36Absent radius (HP:0003974)2.49377117
37Bicuspid aortic valve (HP:0001647)2.49160453
38Vaginal fistula (HP:0004320)2.49059392
39Abnormality of placental membranes (HP:0011409)2.47459572
40Amniotic constriction ring (HP:0009775)2.47459572
41Rib fusion (HP:0000902)2.46615146
42Deviation of the thumb (HP:0009603)2.46279623
43Abnormality of the distal phalanges of the toes (HP:0010182)2.46046508
44Pili torti (HP:0003777)2.39197820
45Rough bone trabeculation (HP:0100670)2.38651531
46Patellar aplasia (HP:0006443)2.36972806
47Intestinal fistula (HP:0100819)2.33010609
48Atresia of the external auditory canal (HP:0000413)2.32224221
49Abnormalities of placenta or umbilical cord (HP:0001194)2.31194012
50Aplasia involving forearm bones (HP:0009822)2.31146656
51Absent forearm bone (HP:0003953)2.31146656
52Abnormal vertebral ossification (HP:0100569)2.29863848
53Soft skin (HP:0000977)2.28911616
54Proximal placement of thumb (HP:0009623)2.28749621
55Squamous cell carcinoma (HP:0002860)2.28075079
56Carpal bone hypoplasia (HP:0001498)2.27608974
57Broad thumb (HP:0011304)2.27263071
58Fused cervical vertebrae (HP:0002949)2.25479380
59Horseshoe kidney (HP:0000085)2.24974057
60Abnormal ossification of hand bones (HP:0005921)2.24582191
61Aplasia/Hypoplasia of the patella (HP:0006498)2.24544956
62Sparse scalp hair (HP:0002209)2.24185115
63Sparse eyelashes (HP:0000653)2.23248239
64Abnormality of the astrocytes (HP:0100707)2.22539438
65Astrocytoma (HP:0009592)2.22539438
66Abnormality of the labia minora (HP:0012880)2.22340391
67Bicornuate uterus (HP:0000813)2.21892001
68Broad phalanges of the hand (HP:0009768)2.19359740
69Breast hypoplasia (HP:0003187)2.16989754
70Milia (HP:0001056)2.16917697
71Reduced subcutaneous adipose tissue (HP:0003758)2.15530845
72Ectopic kidney (HP:0000086)2.14848599
73Degeneration of anterior horn cells (HP:0002398)2.14722171
74Abnormality of the anterior horn cell (HP:0006802)2.14722171
75Abnormality of oral frenula (HP:0000190)2.13055289
76Oligodactyly (HP:0012165)2.12101920
77Progressive muscle weakness (HP:0003323)2.11186579
78Dislocated radial head (HP:0003083)2.10453874
79Abnormality of the calcaneus (HP:0008364)2.09388951
80Tinnitus (HP:0000360)2.09334945
81Ankle contracture (HP:0006466)2.07694174
82Trigonocephaly (HP:0000243)2.07342100
83Birth length less than 3rd percentile (HP:0003561)2.07152878
84Abnormal hand bone ossification (HP:0010660)2.06425052
85Facial hemangioma (HP:0000329)2.06256421
86Mild short stature (HP:0003502)2.06066591
87Abnormality of the 4th metacarpal (HP:0010012)2.05763805
88Plantar hyperkeratosis (HP:0007556)2.05250959
89Increased nuchal translucency (HP:0010880)2.03028590
90Pterygium (HP:0001059)2.03016408
91Oligodactyly (hands) (HP:0001180)2.02062532
92Poikiloderma (HP:0001029)2.01603690
93Septate vagina (HP:0001153)2.00975170
94Biconcave vertebral bodies (HP:0004586)2.00892649
95Chromsome breakage (HP:0040012)2.00433231
96Ovoid vertebral bodies (HP:0003300)2.00289005
97Abnormal hair laboratory examination (HP:0003328)2.00046181
98Abnormality of the radial head (HP:0003995)1.99036157
99Flared iliac wings (HP:0002869)1.97691824
100Abnormality of the preputium (HP:0100587)1.97236195
101Broad finger (HP:0001500)1.96483316
102Trismus (HP:0000211)1.96294249
103Genu recurvatum (HP:0002816)1.95805668
104Broad long bones (HP:0005622)1.95422559
105Anal stenosis (HP:0002025)1.95353651
106Hypoplasia of the radius (HP:0002984)1.94972846
107Aplasia/hypoplasia of the humerus (HP:0006507)1.93620833
108Missing ribs (HP:0000921)1.92922378
109Abnormal umbilical cord blood vessels (HP:0011403)1.92896334
110Single umbilical artery (HP:0001195)1.92896334
111Abnormality of the fetal cardiovascular system (HP:0010948)1.92896334
112Broad phalanx (HP:0006009)1.92335787
113Metatarsus adductus (HP:0001840)1.92209560
114Nail dystrophy (HP:0008404)1.92023494
115Slender long bone (HP:0003100)1.91407149
116Hypoplasia of the uterus (HP:0000013)1.91320590
117Metaphyseal dysplasia (HP:0100255)1.90079372
118Meckel diverticulum (HP:0002245)1.89265391
119Chromosomal breakage induced by crosslinking agents (HP:0003221)1.89035175
120Vertebral fusion (HP:0002948)1.88715965
121Aplasia/hypoplasia of the uterus (HP:0008684)1.88207148
122Short humerus (HP:0005792)1.87957354
123Coronal craniosynostosis (HP:0004440)1.87027885
124Choanal atresia (HP:0000453)1.86274337
125Abnormal number of incisors (HP:0011064)1.84693365
126Hemivertebrae (HP:0002937)1.84147236
127Irregular vertebral endplates (HP:0003301)1.84033797
128Skull defect (HP:0001362)1.83557108
129Wrist flexion contracture (HP:0001239)1.83476177
130Oral leukoplakia (HP:0002745)1.83419937
131Duodenal stenosis (HP:0100867)1.83039827
132Small intestinal stenosis (HP:0012848)1.83039827
133Atrophic scars (HP:0001075)1.82983971
134Aplasia/Hypoplasia of the sternum (HP:0006714)1.82275925
135Glioma (HP:0009733)1.81760996
136Lip pit (HP:0100267)1.81456492
137Natal tooth (HP:0000695)1.81173581
138Short middle phalanx of the 5th finger (HP:0004220)1.81158446
139Flared metaphyses (HP:0003015)1.79949530
140Spinal muscular atrophy (HP:0007269)1.79433420
141Rhabdomyosarcoma (HP:0002859)1.78563423
142Cleft eyelid (HP:0000625)1.78068927
143Absent thumb (HP:0009777)1.78015805
144Aplasia/Hypoplasia of the clavicles (HP:0006710)1.77754794
145Supernumerary spleens (HP:0009799)1.77346462
146Agnosia (HP:0010524)1.77153542
147Hallux valgus (HP:0001822)1.77120785
148Facial cleft (HP:0002006)1.77087737
149Ureteral duplication (HP:0000073)1.76979134
150Premature ovarian failure (HP:0008209)1.76152912
151Abnormality of the ileum (HP:0001549)1.74800617
152Increased density of long bones (HP:0006392)1.74576394
153Preaxial foot polydactyly (HP:0001841)1.74023160
154Preauricular skin tag (HP:0000384)1.73903422
155Ulnar bowing (HP:0003031)1.73521642
156Abdominal situs inversus (HP:0003363)1.72484807
157Abnormality of abdominal situs (HP:0011620)1.72484807
158Hypoplastic pelvis (HP:0008839)1.71752373
159High anterior hairline (HP:0009890)1.70768295
160Alopecia of scalp (HP:0002293)1.70246023
161Abnormal trabecular bone morphology (HP:0100671)1.70193207
162Neonatal short-limb short stature (HP:0008921)1.70180730
163Synostosis of carpal bones (HP:0005048)1.69461833
164Transposition of the great arteries (HP:0001669)1.68164568
165Abnormal connection of the cardiac segments (HP:0011545)1.68164568
166Abnormal ventriculo-arterial connection (HP:0011563)1.68164568
167Deviation of the hallux (HP:0010051)1.68064156
168Aplasia cutis congenita (HP:0001057)1.67634626
169Triphalangeal thumb (HP:0001199)1.66968985
170Broad toe (HP:0001837)1.66866408
171Abnormality of the duodenum (HP:0002246)1.66448162
172Abnormality of dentin (HP:0010299)1.66144544
173Abnormal large intestine physiology (HP:0012700)1.65842959
174Microtia (HP:0008551)1.65186625
175Secondary amenorrhea (HP:0000869)1.64845002
176Short femoral neck (HP:0100864)1.64803856
177Glossoptosis (HP:0000162)1.63300731

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.93894863
2CDC73.79723339
3KSR23.12366003
4MST1R2.95249538
5LATS22.88915596
6ARAF2.68619934
7WEE12.65325519
8MAP3K22.59373664
9EEF2K2.58258818
10CDK122.50159863
11TTK2.43110773
12NEK12.31483998
13NEK22.23253646
14RAF12.20437319
15EIF2AK12.12672186
16EPHA22.10733569
17TSSK62.10304298
18PASK2.08861591
19BRSK22.02319782
20PAK41.97285814
21MAP3K91.95542628
22MKNK11.95383695
23STK38L1.93987490
24KSR11.91031585
25STK161.85968938
26SMG11.85909930
27TESK21.84634461
28IRAK31.84582893
29PLK11.77017226
30MAP3K121.76876231
31MAP3K81.68323803
32RPS6KB21.64215617
33PLK31.59039626
34CDK71.53988857
35CHEK21.47978573
36TGFBR11.47659694
37SCYL21.44733380
38LATS11.40455585
39STK101.37397008
40TLK11.36296216
41TTN1.34712371
42NME11.33192004
43MAP3K31.32086241
44BRSK11.31587476
45LIMK11.31584862
46BRAF1.31086886
47ATR1.30496702
48STK31.28288429
49FLT31.28089127
50AURKB1.27516299
51CDK41.25183122
52AURKA1.24616246
53PLK41.23492305
54PDK21.22784468
55NME21.22722089
56SRPK11.22090456
57PAK21.19007869
58CDK91.12907295
59CHEK11.12154862
60CDK61.10617312
61BMX1.09032116
62MAP3K131.08358150
63VRK21.05920392
64EPHB21.05889234
65TESK11.03798563
66MET1.03748743
67FGFR11.00881707
68MELK0.99253405
69PAK10.99181319
70TRIB30.96008445
71ALK0.91250192
72BRD40.89679379
73CDK20.88473481
74MTOR0.87962817
75ATM0.86705892
76LRRK20.86382674
77CDK80.85707828
78RPS6KA40.84743015
79PNCK0.84575335
80MAP3K10.81230464
81ABL20.80013133
82PTK20.79871122
83NEK90.77881558
84DDR20.77759763
85MAP3K100.77397701
86MOS0.76978408
87STK240.76752010
88TAOK20.75224315
89PKN20.75105122
90ILK0.74446403
91MARK30.74314964
92DYRK30.72876463
93STK40.72526110
94MAP2K10.72270165
95PTK60.70002723
96MKNK20.69985460
97CDK10.67275753
98ZAK0.66288656
99ERBB30.66198071
100CSNK2A20.62012262
101MYLK0.61817194
102CSNK1E0.60932343
103ICK0.60653495
104VRK10.60265864
105NTRK10.59871679
106PRKCI0.59783755
107CSNK1G30.58317802
108RIPK10.58241215
109ERBB40.57688619
110CLK10.56931406
111CSNK1A1L0.55904721
112IRAK20.54814111
113NTRK30.52532703
114MAP3K110.50857242
115PRPF4B0.49451315
116PDGFRA0.49215634
117CSNK2A10.48597842
118PIM20.47802831
119CSNK1G10.45633853
120PBK0.45448313
121MST40.44995096
122CAMK1D0.44246401
123CSNK1D0.44167069
124PRKDC0.42548514
125AKT20.41161941
126FER0.39986918
127MAP2K30.39525097
128PAK60.38979474
129EIF2AK30.38703572
130DAPK30.37488443
131UHMK10.37226838
132RET0.35761231
133MAPKAPK20.34953483
134SIK10.33795971
135KDR0.33774302
136MAPK10.33439492
137MAP3K50.26950493
138EIF2AK20.26789849

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.87139715
2Mismatch repair_Homo sapiens_hsa034303.58223454
3One carbon pool by folate_Homo sapiens_hsa006703.57344546
4RNA transport_Homo sapiens_hsa030133.44149359
5Spliceosome_Homo sapiens_hsa030403.37328119
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.25866858
7Cell cycle_Homo sapiens_hsa041103.04398075
8Ribosome_Homo sapiens_hsa030102.80500820
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.74813105
10Sulfur relay system_Homo sapiens_hsa041222.71585225
11Nucleotide excision repair_Homo sapiens_hsa034202.32893918
12Proteasome_Homo sapiens_hsa030502.30003782
13Base excision repair_Homo sapiens_hsa034102.25416118
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.11641626
15RNA polymerase_Homo sapiens_hsa030202.07992976
16Homologous recombination_Homo sapiens_hsa034401.96345760
17p53 signaling pathway_Homo sapiens_hsa041151.94223104
18Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.83585487
19mRNA surveillance pathway_Homo sapiens_hsa030151.81564987
20Hippo signaling pathway_Homo sapiens_hsa043901.79362419
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.79037310
22Basal cell carcinoma_Homo sapiens_hsa052171.71341359
23Sulfur metabolism_Homo sapiens_hsa009201.71087587
24Fanconi anemia pathway_Homo sapiens_hsa034601.66771891
25Pyrimidine metabolism_Homo sapiens_hsa002401.66570112
26Non-homologous end-joining_Homo sapiens_hsa034501.60329154
27Systemic lupus erythematosus_Homo sapiens_hsa053221.57815149
28MicroRNAs in cancer_Homo sapiens_hsa052061.48975361
29RNA degradation_Homo sapiens_hsa030181.44407313
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.44237393
31TGF-beta signaling pathway_Homo sapiens_hsa043501.37858089
32Basal transcription factors_Homo sapiens_hsa030221.36825448
33Adherens junction_Homo sapiens_hsa045201.34928524
34Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.33497059
35Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.27829375
36Viral carcinogenesis_Homo sapiens_hsa052031.23955583
37Oocyte meiosis_Homo sapiens_hsa041141.23646699
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.23415309
39Biosynthesis of amino acids_Homo sapiens_hsa012301.14732259
40Hedgehog signaling pathway_Homo sapiens_hsa043401.14187188
41Bladder cancer_Homo sapiens_hsa052191.12664047
42Fatty acid elongation_Homo sapiens_hsa000621.12657105
43Small cell lung cancer_Homo sapiens_hsa052221.12000120
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.11871692
45Proteoglycans in cancer_Homo sapiens_hsa052051.09265388
46HTLV-I infection_Homo sapiens_hsa051661.03583636
47Selenocompound metabolism_Homo sapiens_hsa004501.02387887
48Epstein-Barr virus infection_Homo sapiens_hsa051691.02070996
49Galactose metabolism_Homo sapiens_hsa000520.99086989
50ECM-receptor interaction_Homo sapiens_hsa045120.91797129
51Tight junction_Homo sapiens_hsa045300.88244990
52Huntingtons disease_Homo sapiens_hsa050160.87194531
53Parkinsons disease_Homo sapiens_hsa050120.85022084
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81079463
55Colorectal cancer_Homo sapiens_hsa052100.80908876
56Pentose phosphate pathway_Homo sapiens_hsa000300.79681302
57Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77884407
58Thyroid cancer_Homo sapiens_hsa052160.77446469
59Focal adhesion_Homo sapiens_hsa045100.76716954
602-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.76109968
61Chronic myeloid leukemia_Homo sapiens_hsa052200.75682186
62Notch signaling pathway_Homo sapiens_hsa043300.75074526
63Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.72215682
64Pathways in cancer_Homo sapiens_hsa052000.71427246
65Steroid biosynthesis_Homo sapiens_hsa001000.70612635
66Antigen processing and presentation_Homo sapiens_hsa046120.68409068
67Viral myocarditis_Homo sapiens_hsa054160.68394976
68PI3K-Akt signaling pathway_Homo sapiens_hsa041510.67189059
69Wnt signaling pathway_Homo sapiens_hsa043100.65671708
70Melanoma_Homo sapiens_hsa052180.64610558
71Legionellosis_Homo sapiens_hsa051340.64227459
72Other glycan degradation_Homo sapiens_hsa005110.64067506
73Prostate cancer_Homo sapiens_hsa052150.63186938
74Central carbon metabolism in cancer_Homo sapiens_hsa052300.62314113
75Alcoholism_Homo sapiens_hsa050340.62091866
76HIF-1 signaling pathway_Homo sapiens_hsa040660.61895147
77Drug metabolism - other enzymes_Homo sapiens_hsa009830.59368526
78Shigellosis_Homo sapiens_hsa051310.59039033
79mTOR signaling pathway_Homo sapiens_hsa041500.56025445
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.54577727
81Purine metabolism_Homo sapiens_hsa002300.53581353
82Oxidative phosphorylation_Homo sapiens_hsa001900.53391338
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53319196
84Glutathione metabolism_Homo sapiens_hsa004800.52879806
85Apoptosis_Homo sapiens_hsa042100.52593558
86Vibrio cholerae infection_Homo sapiens_hsa051100.52196978
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51852896
88Pyruvate metabolism_Homo sapiens_hsa006200.51736432
89Endometrial cancer_Homo sapiens_hsa052130.51094339
90Sphingolipid metabolism_Homo sapiens_hsa006000.50672235
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49199144
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.48195960
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46982432
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46913975
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45290561
96Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43876170
97Herpes simplex infection_Homo sapiens_hsa051680.42267424
98Leukocyte transendothelial migration_Homo sapiens_hsa046700.42216303
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42186083
100Lysine degradation_Homo sapiens_hsa003100.41153630
101Renal cell carcinoma_Homo sapiens_hsa052110.41140515
102Rap1 signaling pathway_Homo sapiens_hsa040150.40810875
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.40740836
104Metabolic pathways_Homo sapiens_hsa011000.40427198
105ErbB signaling pathway_Homo sapiens_hsa040120.38861007
106Prion diseases_Homo sapiens_hsa050200.38787244
107Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38586175
108Carbon metabolism_Homo sapiens_hsa012000.37412088
109Folate biosynthesis_Homo sapiens_hsa007900.37027748
110Alzheimers disease_Homo sapiens_hsa050100.36978623
111Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36013384
112Hepatitis B_Homo sapiens_hsa051610.35841168
113Regulation of autophagy_Homo sapiens_hsa041400.34965326
114Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.34617415
115Amoebiasis_Homo sapiens_hsa051460.32686894
116Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.31868141
117Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30050163
118Non-small cell lung cancer_Homo sapiens_hsa052230.29721943
119Phenylalanine metabolism_Homo sapiens_hsa003600.29584882
120Fructose and mannose metabolism_Homo sapiens_hsa000510.27838809
121Arginine and proline metabolism_Homo sapiens_hsa003300.27111529
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.27014081
123FoxO signaling pathway_Homo sapiens_hsa040680.25450668
124Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.25219046
125Pancreatic cancer_Homo sapiens_hsa052120.24216069
126Neurotrophin signaling pathway_Homo sapiens_hsa047220.23808091
127Melanogenesis_Homo sapiens_hsa049160.18575539
128Glioma_Homo sapiens_hsa052140.17655242
129N-Glycan biosynthesis_Homo sapiens_hsa005100.15983716

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