HORMAD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a HORMA domain-containing protein. HORMA domains are involved in chromatin binding and play a role in cell cycle regulation. The encoded protein may play a role in meiosis, and expression of this gene is a potential marker for cancer. A pseudogene of this gene is located on the long arm of chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA methylation involved in gamete generation (GO:0043046)7.99713961
2* synaptonemal complex assembly (GO:0007130)7.89747538
3male meiosis (GO:0007140)7.89426600
4* synaptonemal complex organization (GO:0070193)7.74078809
5male meiosis I (GO:0007141)6.55306544
6* meiotic nuclear division (GO:0007126)6.05559018
7* chromosome organization involved in meiosis (GO:0070192)5.87735541
8cilium or flagellum-dependent cell motility (GO:0001539)5.86056105
9meiosis I (GO:0007127)5.84697847
10fusion of sperm to egg plasma membrane (GO:0007342)5.49714766
11nuclear pore organization (GO:0006999)5.11543857
12nuclear pore complex assembly (GO:0051292)5.05650832
13gene silencing by RNA (GO:0031047)4.79187369
14histone H3-K9 demethylation (GO:0033169)4.77717774
15* meiotic cell cycle process (GO:1903046)4.66794160
16positive regulation of meiosis (GO:0045836)4.60890620
17spermatid development (GO:0007286)4.50862221
18sperm-egg recognition (GO:0035036)4.39887220
19mitotic metaphase plate congression (GO:0007080)4.35701335
20binding of sperm to zona pellucida (GO:0007339)4.35202090
21positive regulation of meiotic cell cycle (GO:0051446)4.31470646
22* regulation of meiosis I (GO:0060631)4.28311124
23acrosome reaction (GO:0007340)4.27321936
24reciprocal DNA recombination (GO:0035825)4.17898922
25reciprocal meiotic recombination (GO:0007131)4.17898922
26meiotic chromosome segregation (GO:0045132)4.16115011
27histone exchange (GO:0043486)4.08216911
28DNA replication-dependent nucleosome assembly (GO:0006335)4.06180375
29DNA replication-dependent nucleosome organization (GO:0034723)4.06180375
30DNA alkylation (GO:0006305)4.04418805
31DNA methylation (GO:0006306)4.04418805
32axonemal dynein complex assembly (GO:0070286)4.03047278
33meiotic cell cycle (GO:0051321)4.02861409
34plasma membrane fusion (GO:0045026)4.02656767
35DNA replication checkpoint (GO:0000076)3.98116617
36protein K6-linked ubiquitination (GO:0085020)3.92670810
37pore complex assembly (GO:0046931)3.90978306
38cell-cell recognition (GO:0009988)3.90322092
39purine nucleobase biosynthetic process (GO:0009113)3.84304081
40sperm motility (GO:0030317)3.81652562
41DNA synthesis involved in DNA repair (GO:0000731)3.79928914
42protein targeting to Golgi (GO:0000042)3.77008815
43metaphase plate congression (GO:0051310)3.76491520
44regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.75077556
45* female gamete generation (GO:0007292)3.74721449
46gonadal mesoderm development (GO:0007506)3.70452881
47regulation of DNA endoreduplication (GO:0032875)3.70336912
48microtubule depolymerization (GO:0007019)3.69671722
49acrosome assembly (GO:0001675)3.69214290
50resolution of meiotic recombination intermediates (GO:0000712)3.68671448
51mitotic nuclear envelope disassembly (GO:0007077)3.68502975
52multicellular organism reproduction (GO:0032504)3.67438878
53attachment of spindle microtubules to kinetochore (GO:0008608)3.67123153
54proteasome assembly (GO:0043248)3.66071214
55regulation of histone H3-K9 methylation (GO:0051570)3.61040205
56nucleobase biosynthetic process (GO:0046112)3.59373271
57regulation of centriole replication (GO:0046599)3.57341699
58chromatin remodeling at centromere (GO:0031055)3.56862977
59establishment of protein localization to Golgi (GO:0072600)3.55710571
60monoubiquitinated protein deubiquitination (GO:0035520)3.54101236
61retrograde transport, vesicle recycling within Golgi (GO:0000301)3.49804311
62membrane disassembly (GO:0030397)3.47557269
63nuclear envelope disassembly (GO:0051081)3.47557269
64synapsis (GO:0007129)3.47133385
65motile cilium assembly (GO:0044458)3.46586497
66mitotic chromosome condensation (GO:0007076)3.45399004
67gene silencing (GO:0016458)3.44768737
68cell wall macromolecule metabolic process (GO:0044036)3.43631688
69cell wall macromolecule catabolic process (GO:0016998)3.43631688
70chaperone-mediated protein complex assembly (GO:0051131)3.41510787
71protein localization to chromosome, centromeric region (GO:0071459)3.35410423
72heterochromatin organization (GO:0070828)3.34143580
73DNA replication initiation (GO:0006270)3.32665235
74protein localization to kinetochore (GO:0034501)3.32367551
75* germ cell development (GO:0007281)3.30299537
76ribosome assembly (GO:0042255)3.28946871
77regulation of centrosome cycle (GO:0046605)3.28871657
78removal of superoxide radicals (GO:0019430)3.28844077
79cellular response to superoxide (GO:0071451)3.28844077
80cellular response to oxygen radical (GO:0071450)3.28844077
81kinetochore organization (GO:0051383)3.28400851
82epithelial cilium movement (GO:0003351)3.28279520
83DNA methylation or demethylation (GO:0044728)3.28237209
84histone H3-K36 demethylation (GO:0070544)3.26385055
85ribosome biogenesis (GO:0042254)3.25369416
86* gamete generation (GO:0007276)3.25229084
87positive regulation of chromosome segregation (GO:0051984)3.25039422
88fertilization (GO:0009566)3.24545522
89centriole replication (GO:0007099)3.22534094
90regulation of spindle organization (GO:0090224)3.22435073
91* regulation of chromosome segregation (GO:0051983)3.22367095
92* oogenesis (GO:0048477)3.21472022
93DNA replication-independent nucleosome assembly (GO:0006336)3.21462828
94DNA replication-independent nucleosome organization (GO:0034724)3.21462828
95CENP-A containing nucleosome assembly (GO:0034080)3.17865889
96mitotic sister chromatid segregation (GO:0000070)3.17212995
97mitotic sister chromatid cohesion (GO:0007064)3.16471127
98negative regulation of chromosome segregation (GO:0051985)3.16124450
99intra-S DNA damage checkpoint (GO:0031573)3.15487337
100chromosome condensation (GO:0030261)3.12860041
101epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.12017530
102negative regulation of mitotic sister chromatid separation (GO:2000816)3.10656264
103negative regulation of mitotic sister chromatid segregation (GO:0033048)3.10656264
104negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.10656264
105negative regulation of sister chromatid segregation (GO:0033046)3.10656264
106regulation of double-strand break repair via homologous recombination (GO:0010569)3.10651941
107* regulation of meiotic cell cycle (GO:0051445)3.10135518
108* male gamete generation (GO:0048232)3.10008235
109* spermatogenesis (GO:0007283)3.09585652
110regulation of mitotic metaphase/anaphase transition (GO:0030071)3.06902191
111spindle checkpoint (GO:0031577)3.05743692
112* sister chromatid cohesion (GO:0007062)3.05207149
113mitotic spindle checkpoint (GO:0071174)3.04429890
114establishment of chromosome localization (GO:0051303)3.03976410
115negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.02428914
116sex differentiation (GO:0007548)3.02015113
117regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.00630013
118* chromosome organization (GO:0051276)3.00356816
119DNA packaging (GO:0006323)2.99813438
120mitotic spindle assembly checkpoint (GO:0007094)2.99632171
121spindle assembly checkpoint (GO:0071173)2.97927345
122positive regulation of response to oxidative stress (GO:1902884)2.96175824
123positive regulation of cellular response to oxidative stress (GO:1900409)2.96175824
124oocyte maturation (GO:0001556)2.93657565
125DNA biosynthetic process (GO:0071897)2.87233207
126seminiferous tubule development (GO:0072520)2.81998098
127negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.80156569
128* cellular process involved in reproduction in multicellular organism (GO:0022412)2.79622050
129N-terminal protein amino acid acetylation (GO:0006474)2.79148697
130* nuclear division (GO:0000280)2.77466245
131negative regulation of inclusion body assembly (GO:0090084)2.77248901
132spindle assembly involved in mitosis (GO:0090307)2.74431745
133positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.74130026
134positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.74130026
135positive regulation of mitotic sister chromatid separation (GO:1901970)2.74130026
136negative regulation of DNA repair (GO:0045738)2.72739519
137negative regulation of NF-kappaB import into nucleus (GO:0042347)2.70676042
138microtubule nucleation (GO:0007020)2.68891916
139rRNA methylation (GO:0031167)2.68606784
140protein localization to Golgi apparatus (GO:0034067)2.68529485
141piRNA metabolic process (GO:0034587)10.7540447

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.51876280
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.22430988
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.16639975
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.51209490
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.44635322
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.03239705
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.91315321
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.72826380
9KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.52352533
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.42413463
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.41683402
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.33196607
13AR_21909140_ChIP-Seq_LNCAP_Human2.31350625
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.31327944
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.30859759
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.28786838
17* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.24968398
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.24860174
19* MYCN_18555785_ChIP-Seq_MESCs_Mouse2.20691282
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.18523483
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.13022572
22IRF8_21731497_ChIP-ChIP_J774_Mouse2.10718072
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.10495833
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.08605526
25KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.06293430
26KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.06293430
27KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.06293430
28POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.04861914
29* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.04786925
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.03101020
31* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.94466832
32EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.90793159
33IGF1R_20145208_ChIP-Seq_DFB_Human1.90421804
34XRN2_22483619_ChIP-Seq_HELA_Human1.89967635
35VDR_23849224_ChIP-Seq_CD4+_Human1.85888561
36E2F1_21310950_ChIP-Seq_MCF-7_Human1.75121765
37SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.73056066
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.69897824
39NANOG_18555785_ChIP-Seq_MESCs_Mouse1.69805063
40CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.65464684
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64168199
42STAT3_1855785_ChIP-Seq_MESCs_Mouse1.62360844
43VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.60599827
44PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.60550449
45RBPJ_22232070_ChIP-Seq_NCS_Mouse1.56416251
46GABP_19822575_ChIP-Seq_HepG2_Human1.55055019
47NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.54137040
48DCP1A_22483619_ChIP-Seq_HELA_Human1.53953514
49HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.52948778
50E2F1_18555785_ChIP-Seq_MESCs_Mouse1.50805792
51FOXP3_21729870_ChIP-Seq_TREG_Human1.48058082
52NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.47343604
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44492015
54ZNF274_21170338_ChIP-Seq_K562_Hela1.42754657
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.40923755
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.39649410
57KDM5A_27292631_Chip-Seq_BREAST_Human1.38871473
58YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38190465
59POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.36272535
60ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35541126
61TTF2_22483619_ChIP-Seq_HELA_Human1.34238167
62KLF4_18555785_ChIP-Seq_MESCs_Mouse1.33997050
63KAP1_22055183_ChIP-Seq_ESCs_Mouse1.32043710
64SOX2_18555785_ChIP-Seq_MESCs_Mouse1.27592037
65THAP11_20581084_ChIP-Seq_MESCs_Mouse1.27423039
66GATA3_26560356_Chip-Seq_TH1_Human1.25701166
67PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25483580
68HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22839325
69PKCTHETA_26484144_Chip-Seq_BREAST_Human1.20659116
70GATA1_26923725_Chip-Seq_HPCs_Mouse1.20514332
71ER_23166858_ChIP-Seq_MCF-7_Human1.19350394
72FUS_26573619_Chip-Seq_HEK293_Human1.19226217
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.18782145
74HOXB7_26014856_ChIP-Seq_BT474_Human1.16652719
75FOXA1_21572438_ChIP-Seq_LNCaP_Human1.16578645
76BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.16218515
77POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15903011
78EGR1_19374776_ChIP-ChIP_THP-1_Human1.15003260
79SPI1_23547873_ChIP-Seq_NB4_Human1.14656934
80GATA3_26560356_Chip-Seq_TH2_Human1.09152345
81CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.08315499
82SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.07468921
83FOXA1_25329375_ChIP-Seq_VCAP_Human1.07445652
84FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07445652
85FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.06871243
86ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06447059
87GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.05870023
88MYB_21317192_ChIP-Seq_ERMYB_Mouse1.00967656
89ELK1_19687146_ChIP-ChIP_HELA_Human1.00744416
90SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.00619299
91FOXH1_21741376_ChIP-Seq_EPCs_Human0.98676713
92* RBPJ_21746931_ChIP-Seq_IB4_Human0.98224333
93NANOG_21062744_ChIP-ChIP_HESCs_Human0.97625909
94E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97563532
95GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96073090
96ERA_21632823_ChIP-Seq_H3396_Human0.96048820
97* ETV1_20927104_ChIP-Seq_GIST48_Human0.95352245
98VDR_22108803_ChIP-Seq_LS180_Human0.95330445
99IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.94071951
100NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.93848209
101* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.93100570
102SMAD4_21741376_ChIP-Seq_EPCs_Human0.92663853
103FLI1_27457419_Chip-Seq_LIVER_Mouse0.92515472
104HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.91966063
105MYB_26560356_Chip-Seq_TH2_Human0.91306371
106TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90297398
107PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88930569
108TP53_22573176_ChIP-Seq_HFKS_Human0.88785519
109DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.87324916
110TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.87203022
111RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.86343992
112UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.85868858
113KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.85790327
114NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.85762273
115TCF3_18692474_ChIP-Seq_MESCs_Mouse0.85678487
116SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.85624467
117EGR1_23403033_ChIP-Seq_LIVER_Mouse0.83725138
118RUNX1_26923725_Chip-Seq_HPCs_Mouse0.83593332
119SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.83386635
120RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.83212267
121SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.82853856
122BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.81843255
123SOX2_18692474_ChIP-Seq_MESCs_Mouse0.81509037
124AUTS2_25519132_ChIP-Seq_293T-REX_Human0.81411056
125IRF8_27001747_Chip-Seq_BMDM_Mouse0.81252287
126POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.81142592
127ELF1_17652178_ChIP-ChIP_JURKAT_Human0.80597634
128CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.80076272
129GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.79535414
130RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.78989726
131TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.78823756
132CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.78670317
133SRF_21415370_ChIP-Seq_HL-1_Mouse0.77899528
134ZNF263_19887448_ChIP-Seq_K562_Human0.76961059
135TP63_19390658_ChIP-ChIP_HaCaT_Human0.76354323
136TCF3_18692474_ChIP-Seq_MEFs_Mouse0.75089145
137BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.74839784
138* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.74754586
139POU5F1_16518401_ChIP-PET_MESCs_Mouse0.74029211
140ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.73222326
141KAP1_27257070_Chip-Seq_ESCs_Mouse0.73184650
142NANOG_18692474_ChIP-Seq_MESCs_Mouse0.73048676
143TFEB_21752829_ChIP-Seq_HELA_Human0.72855877
144NANOG_18692474_ChIP-Seq_MEFs_Mouse0.71956361
145ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.71312012
146CIITA_25753668_ChIP-Seq_RAJI_Human0.71118495
147NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.70279047
148YY1_22570637_ChIP-Seq_MALME-3M_Human0.69730686
149SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.67966655
150MYC_18940864_ChIP-ChIP_HL60_Human0.67882267

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation7.44052088
2MP0008057_abnormal_DNA_replication4.79831597
3MP0005410_abnormal_fertilization4.72877179
4MP0010094_abnormal_chromosome_stability4.33544408
5MP0003693_abnormal_embryo_hatching4.28805715
6MP0003111_abnormal_nucleus_morphology3.91468107
7MP0002210_abnormal_sex_determination3.85993058
8MP0001929_abnormal_gametogenesis3.81839319
9MP0008058_abnormal_DNA_repair3.74281469
10MP0003698_abnormal_male_reproductive3.34378224
11MP0004957_abnormal_blastocyst_morpholog3.34348173
12MP0003077_abnormal_cell_cycle3.29530809
13MP0001145_abnormal_male_reproductive3.20088658
14MP0003786_premature_aging3.15711567
15MP0008995_early_reproductive_senescence2.97465591
16MP0000569_abnormal_digit_pigmentation2.96902832
17MP0000653_abnormal_sex_gland2.81976024
18MP0000015_abnormal_ear_pigmentation2.72890827
19MP0008007_abnormal_cellular_replicative2.60077416
20MP0002653_abnormal_ependyma_morphology2.42833023
21MP0003123_paternal_imprinting2.40491002
22MP0005174_abnormal_tail_pigmentation2.28854672
23MP0001730_embryonic_growth_arrest2.11924521
24MP0008004_abnormal_stomach_pH2.09553218
25MP0003718_maternal_effect2.05921221
26MP0002161_abnormal_fertility/fecundity2.02895445
27MP0008932_abnormal_embryonic_tissue2.01223039
28MP0003186_abnormal_redox_activity1.90106787
29MP0010307_abnormal_tumor_latency1.87411506
30MP0000350_abnormal_cell_proliferation1.77704042
31MP0005408_hypopigmentation1.75954464
32MP0002160_abnormal_reproductive_system1.70671182
33MP0005058_abnormal_lysosome_morphology1.68693063
34MP0005310_abnormal_salivary_gland1.58756788
35MP0000372_irregular_coat_pigmentation1.54725274
36MP0001672_abnormal_embryogenesis/_devel1.49066592
37MP0005380_embryogenesis_phenotype1.49066592
38MP0005377_hearing/vestibular/ear_phenot1.47115080
39MP0003878_abnormal_ear_physiology1.47115080
40MP0002095_abnormal_skin_pigmentation1.43537336
41MP0003183_abnormal_peptide_metabolism1.41594541
42MP0001697_abnormal_embryo_size1.38672652
43MP0002084_abnormal_developmental_patter1.33672860
44MP0010352_gastrointestinal_tract_polyps1.33488649
45MP0002085_abnormal_embryonic_tissue1.31773382
46MP0005075_abnormal_melanosome_morpholog1.30047639
47MP0001119_abnormal_female_reproductive1.28499149
48MP0003984_embryonic_growth_retardation1.24692610
49MP0002080_prenatal_lethality1.22127396
50MP0002088_abnormal_embryonic_growth/wei1.20635692
51MP0002132_abnormal_respiratory_system1.20480291
52MP0003890_abnormal_embryonic-extraembry1.19595354
53MP0003806_abnormal_nucleotide_metabolis1.18733312
54MP0005389_reproductive_system_phenotype1.18408043
55MP0004197_abnormal_fetal_growth/weight/1.17937899
56MP0001986_abnormal_taste_sensitivity1.13874967
57MP0000313_abnormal_cell_death1.11978331
58MP0005409_darkened_coat_color1.11824692
59MP0000678_abnormal_parathyroid_gland1.11782924
60MP0002086_abnormal_extraembryonic_tissu1.08337485
61MP0002877_abnormal_melanocyte_morpholog1.06513354
62MP0003699_abnormal_female_reproductive1.06060121
63MP0010368_abnormal_lymphatic_system1.05019267
64MP0000371_diluted_coat_color1.03771211
65MP0005076_abnormal_cell_differentiation1.03066415
66MP0004381_abnormal_hair_follicle0.99924429
67MP0001293_anophthalmia0.99877198
68MP0003941_abnormal_skin_development0.97685525
69MP0003724_increased_susceptibility_to0.97356332
70MP0001661_extended_life_span0.95345294
71MP0003315_abnormal_perineum_morphology0.91716020
72MP0003121_genomic_imprinting0.90628900
73MP0004808_abnormal_hematopoietic_stem0.90499814
74MP0002019_abnormal_tumor_incidence0.88233123
75MP0003136_yellow_coat_color0.87129948
76MP0002796_impaired_skin_barrier0.86754966
77MP0005647_abnormal_sex_gland0.86562258
78MP0003828_pulmonary_edema0.85388577
79MP0003936_abnormal_reproductive_system0.80644626
80MP0005623_abnormal_meninges_morphology0.79475269
81MP0003119_abnormal_digestive_system0.78085594
82MP0000358_abnormal_cell_content/0.77407006
83MP0005395_other_phenotype0.76824973
84MP0009697_abnormal_copulation0.76104538
85MP0001835_abnormal_antigen_presentation0.75019869
86MP0009672_abnormal_birth_weight0.74337298
87MP0004782_abnormal_surfactant_physiolog0.74238108
88MP0002075_abnormal_coat/hair_pigmentati0.73375920
89MP0003656_abnormal_erythrocyte_physiolo0.72190869
90MP0004133_heterotaxia0.71783040
91MP0006292_abnormal_olfactory_placode0.70879049
92MP0003567_abnormal_fetal_cardiomyocyte0.68884352
93MP0002277_abnormal_respiratory_mucosa0.68867365
94MP0009703_decreased_birth_body0.66850932
95MP0001324_abnormal_eye_pigmentation0.66284479
96MP0005397_hematopoietic_system_phenotyp0.64338575
97MP0001545_abnormal_hematopoietic_system0.64338575
98MP0004233_abnormal_muscle_weight0.63160478
99MP0003646_muscle_fatigue0.63070487
100MP0005384_cellular_phenotype0.61233697
101MP0001186_pigmentation_phenotype0.61119441
102MP0005621_abnormal_cell_physiology0.60941315
103MP0009115_abnormal_fat_cell0.60590206
104MP0002396_abnormal_hematopoietic_system0.60226183
105MP0008260_abnormal_autophagy0.59518045
106MP0001727_abnormal_embryo_implantation0.59387816
107MP0005266_abnormal_metabolism0.59231779
108MP0005451_abnormal_body_composition0.58451794
109MP0003943_abnormal_hepatobiliary_system0.57282571
110MP0002419_abnormal_innate_immunity0.56600894
111MP0003221_abnormal_cardiomyocyte_apopto0.54986558
112MP0003937_abnormal_limbs/digits/tail_de0.54926527
113MP0002928_abnormal_bile_duct0.54818817
114MP0002092_abnormal_eye_morphology0.54704111
115MP0000383_abnormal_hair_follicle0.53984028
116MP0002723_abnormal_immune_serum0.53680667
117MP0001919_abnormal_reproductive_system0.52306206
118MP0003861_abnormal_nervous_system0.52259258
119MP0002269_muscular_atrophy0.52245047
120MP0005376_homeostasis/metabolism_phenot0.51733515
121MP0001849_ear_inflammation0.51648368
122MP0004084_abnormal_cardiac_muscle0.50237552
123MP0005167_abnormal_blood-brain_barrier0.49527117
124MP0009785_altered_susceptibility_to0.49277430
125MP0001191_abnormal_skin_condition0.49179832
126MP0005319_abnormal_enzyme/_coenzyme0.48014864
127MP0000432_abnormal_head_morphology0.43798402
128MP0006036_abnormal_mitochondrial_physio0.43224646
129MP0000490_abnormal_crypts_of0.42838948
130MP0005670_abnormal_white_adipose0.42275371
131MP0002102_abnormal_ear_morphology0.42040159
132MP0000647_abnormal_sebaceous_gland0.38656214
133MP0000537_abnormal_urethra_morphology0.38095100
134MP0006035_abnormal_mitochondrial_morpho0.36769590
135MP0000428_abnormal_craniofacial_morphol0.35743885
136MP0000427_abnormal_hair_cycle0.35721433
137MP0005391_vision/eye_phenotype0.35409511
138MP0003115_abnormal_respiratory_system0.35109441
139MP0001286_abnormal_eye_development0.33059303
140MP0006072_abnormal_retinal_apoptosis0.32406832
141MP0003787_abnormal_imprinting0.32332160
142MP0002111_abnormal_tail_morphology0.30856921
143MP0001915_intracranial_hemorrhage0.30523482

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.79012184
2Volvulus (HP:0002580)6.23629337
3Dynein arm defect of respiratory motile cilia (HP:0012255)5.74577379
4Absent/shortened dynein arms (HP:0200106)5.74577379
5Azoospermia (HP:0000027)5.50038821
6Abnormal spermatogenesis (HP:0008669)5.38793808
7Degeneration of the lateral corticospinal tracts (HP:0002314)4.91853146
8Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.91853146
9Abnormality of the lower motor neuron (HP:0002366)4.61216538
10Abnormal respiratory motile cilium physiology (HP:0012261)4.49490279
11Gonadotropin excess (HP:0000837)4.37199585
12Rhinitis (HP:0012384)4.30198141
13Abnormal respiratory epithelium morphology (HP:0012253)4.26736208
14Abnormal respiratory motile cilium morphology (HP:0005938)4.26736208
15Tubulointerstitial nephritis (HP:0001970)4.26645724
16Impulsivity (HP:0100710)4.14563769
17Supernumerary spleens (HP:0009799)4.07290966
18Abnormality of the corticospinal tract (HP:0002492)3.94443104
19Resting tremor (HP:0002322)3.93640871
20Birth length less than 3rd percentile (HP:0003561)3.90553848
21Chronic bronchitis (HP:0004469)3.79372775
22Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.78049262
23Breast hypoplasia (HP:0003187)3.71371540
24Chromsome breakage (HP:0040012)3.69788833
25Osteomalacia (HP:0002749)3.65603778
26Selective tooth agenesis (HP:0001592)3.61009382
27Abnormality of the anterior horn cell (HP:0006802)3.60519375
28Degeneration of anterior horn cells (HP:0002398)3.60519375
29Chromosomal breakage induced by crosslinking agents (HP:0003221)3.59386233
30Abnormal ciliary motility (HP:0012262)3.42905142
3111 pairs of ribs (HP:0000878)3.41743032
32Abnormality of the labia minora (HP:0012880)3.41595587
33Infertility (HP:0000789)3.30362657
34Metaphyseal cupping (HP:0003021)3.24293864
35Menstrual irregularities (HP:0000858)3.18623561
36Amyotrophic lateral sclerosis (HP:0007354)3.15357213
37Carpal bone hypoplasia (HP:0001498)3.13090963
38Ependymoma (HP:0002888)3.12753197
39Truncal obesity (HP:0001956)3.07591992
40Abnormality of chromosome stability (HP:0003220)3.02925009
41Horizontal nystagmus (HP:0000666)3.00521480
42Meckel diverticulum (HP:0002245)3.00505166
43Scotoma (HP:0000575)2.97309579
44Increased nuchal translucency (HP:0010880)2.92209654
45Abnormality of the preputium (HP:0100587)2.84986724
46Absent radius (HP:0003974)2.81141157
47Abnormality of the ileum (HP:0001549)2.79693685
48Male infertility (HP:0003251)2.76551860
49Upper motor neuron abnormality (HP:0002127)2.76325419
50Aplasia/Hypoplasia of the uvula (HP:0010293)2.75520373
51Aplasia/Hypoplasia of the macula (HP:0008059)2.68816313
52Vertebral arch anomaly (HP:0008438)2.67337056
53Loss of speech (HP:0002371)2.65222605
54Absent forearm bone (HP:0003953)2.64703432
55Aplasia involving forearm bones (HP:0009822)2.64703432
56Patellar aplasia (HP:0006443)2.64164395
57Nephronophthisis (HP:0000090)2.58035011
58Facial hemangioma (HP:0000329)2.57331866
59Disinhibition (HP:0000734)2.53175756
60Blepharitis (HP:0000498)2.50731869
61Nasal polyposis (HP:0100582)2.49073741
62Missing ribs (HP:0000921)2.48992705
63Flat occiput (HP:0005469)2.48800179
64Impaired vibration sensation in the lower limbs (HP:0002166)2.47585866
65Ectopic kidney (HP:0000086)2.47520381
66Absent thumb (HP:0009777)2.45508473
67Facial cleft (HP:0002006)2.44776585
68Aplasia/Hypoplasia of the patella (HP:0006498)2.43740138
69Recurrent bacterial skin infections (HP:0005406)2.41319955
70Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.41291048
71Fibular hypoplasia (HP:0003038)2.40769725
72Aplasia/Hypoplasia affecting the retina (HP:0008061)2.40276435
73Sloping forehead (HP:0000340)2.38126453
74Abnormality of DNA repair (HP:0003254)2.38048515
75Abnormality of lateral ventricle (HP:0030047)2.37372459
76Medulloblastoma (HP:0002885)2.35760398
77Duodenal stenosis (HP:0100867)2.35279245
78Small intestinal stenosis (HP:0012848)2.35279245
79Atrophy/Degeneration involving motor neurons (HP:0007373)2.35195252
80Abnormality of the costochondral junction (HP:0000919)2.33750493
81Abnormality of the renal collecting system (HP:0004742)2.29172543
82Oligodactyly (hands) (HP:0001180)2.28910522
83Bronchiectasis (HP:0002110)2.28482227
84Hypoplasia of the fovea (HP:0007750)2.23764747
85Aplasia/Hypoplasia of the fovea (HP:0008060)2.23764747
86Hypergonadotropic hypogonadism (HP:0000815)2.23617579
87Low anterior hairline (HP:0000294)2.21289099
88Abnormality of chromosome segregation (HP:0002916)2.21027039
89Abnormality of the astrocytes (HP:0100707)2.20916777
90Astrocytoma (HP:0009592)2.20916777
91Shoulder girdle muscle weakness (HP:0003547)2.20893380
92Cerebral hypomyelination (HP:0006808)2.20171355
93Breast carcinoma (HP:0003002)2.20167904
94Hand muscle atrophy (HP:0009130)2.18473077
95Oligodactyly (HP:0012165)2.17599078
96Oral leukoplakia (HP:0002745)2.16563610
97Agnosia (HP:0010524)2.14922734
98Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.13904445
99Rhabdomyosarcoma (HP:0002859)2.13349035
100Recurrent abscess formation (HP:0002722)2.12111910
101Rough bone trabeculation (HP:0100670)2.11478071
102Glioma (HP:0009733)2.11281383
103Horseshoe kidney (HP:0000085)2.09688645
104Abnormal lung lobation (HP:0002101)2.08375382
105Hypoplasia of the uterus (HP:0000013)2.06999409
106Proximal placement of thumb (HP:0009623)2.06896609
107Hypoplasia of the capital femoral epiphysis (HP:0003090)2.06726481
108Aplasia/hypoplasia of the humerus (HP:0006507)2.06415271
109Postural instability (HP:0002172)2.06207523
110Prominent nose (HP:0000448)2.05316329
111Spinal muscular atrophy (HP:0007269)2.04256519
112Premature ovarian failure (HP:0008209)2.04247562
113Hyperkalemia (HP:0002153)2.03667825
114Abnormality of the fovea (HP:0000493)2.01885235
115Abnormality of chloride homeostasis (HP:0011422)2.01327712
116Duplicated collecting system (HP:0000081)2.00421789
117Progressive external ophthalmoplegia (HP:0000590)2.00115517
118Hypoplasia of the radius (HP:0002984)1.99886104
119Delayed epiphyseal ossification (HP:0002663)1.99658657
120Aplasia/Hypoplasia of the earlobes (HP:0009906)1.99486868
121Bronchitis (HP:0012387)1.97541510
122Lip pit (HP:0100267)1.95847749
123Spontaneous abortion (HP:0005268)1.95551956
124Chronic hepatic failure (HP:0100626)1.94939280
125Neoplasm of the oral cavity (HP:0100649)1.94678850
126Abnormality of pyrimidine metabolism (HP:0004353)1.94294579
127Colon cancer (HP:0003003)1.92230323
128Ureteral duplication (HP:0000073)1.90972571
129Secondary amenorrhea (HP:0000869)1.90473863
130Abnormality of the carotid arteries (HP:0005344)1.89277099
131Neoplasm of the pancreas (HP:0002894)1.88501605
132Myelodysplasia (HP:0002863)1.88414837
133Abnormality of the duodenum (HP:0002246)1.88150658
134Tongue fasciculations (HP:0001308)1.87681639
135Uterine leiomyosarcoma (HP:0002891)1.87265725
136Leiomyosarcoma (HP:0100243)1.87265725
137Aplasia/Hypoplasia of the fibula (HP:0006492)1.86902806
138Gingivitis (HP:0000230)1.86651816
139Abnormality of the nasal mucosa (HP:0000433)1.86390846
140Capillary hemangiomas (HP:0005306)1.86023421
141Bone marrow hypocellularity (HP:0005528)1.85106225
142Abnormality of the renal medulla (HP:0100957)1.84666211
143Nephroblastoma (Wilms tumor) (HP:0002667)1.83116769
144Widely spaced teeth (HP:0000687)1.82848166
145Spastic gait (HP:0002064)1.81890902
146Median cleft lip (HP:0000161)1.80979887
147Short thumb (HP:0009778)1.80307336
148Abnormality of macrophages (HP:0004311)1.78632007
149Deviation of the thumb (HP:0009603)1.78353923
150Papillary thyroid carcinoma (HP:0002895)1.77474832
151Type II lissencephaly (HP:0007260)1.77091696
152Upper limb muscle weakness (HP:0003484)1.76720162
153Biliary tract neoplasm (HP:0100574)1.76423156
154Short ribs (HP:0000773)1.76138826
155Shawl scrotum (HP:0000049)1.75036717
156Insulin-resistant diabetes mellitus (HP:0000831)1.73806758
157Muscle fibrillation (HP:0010546)1.72569773
158Short humerus (HP:0005792)1.72452755
159Heterotopia (HP:0002282)1.71751045
160Rimmed vacuoles (HP:0003805)1.71221558
161Sandal gap (HP:0001852)1.70701931
162Embryonal renal neoplasm (HP:0011794)1.69699088
163Severe visual impairment (HP:0001141)1.69199725
164Ocular albinism (HP:0001107)1.68093907
165Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.67870784
166Abnormality of alanine metabolism (HP:0010916)1.67870784
167Hyperalaninemia (HP:0003348)1.67870784
168Hyperpituitarism (HP:0010514)1.67611715

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK35.72105917
2PDK45.72105917
3CDK194.58466297
4WEE14.24323646
5PDK23.90410058
6CDC73.85729856
7NEK23.18062012
8BUB13.17323518
9MAP3K23.01203651
10ACVR1B2.89908771
11CDK122.82787494
12MST1R2.73967419
13TTK2.71585428
14PNCK2.55995027
15BLK2.43032534
16EIF2AK12.10905787
17SRPK12.09619385
18PLK12.06414110
19PLK42.02820486
20BRSK21.92140200
21NEK11.87684417
22PLK21.87535760
23DYRK31.75327513
24LMTK21.61073556
25CAMK1G1.60982552
26ATR1.60422096
27TESK11.58979809
28CHEK21.54626445
29KSR21.53393604
30PLK31.46845044
31CHEK11.45902587
32FGR1.37460015
33OXSR11.36129528
34CDK71.35453076
35EPHA21.28944612
36STK31.27836665
37KSR11.27431115
38EIF2AK31.26632330
39TSSK61.26386222
40STK38L1.25860904
41ICK1.22707487
42AURKB1.17287660
43YES11.17094251
44AKT31.12793210
45CCNB11.11574802
46PRKD31.08715999
47STK241.08080406
48MKNK21.07679101
49ATM1.05829790
50BRSK11.03385648
51PIK3CG1.02831341
52BRD41.01183229
53BMX1.00928144
54PASK0.97565300
55PDPK10.90568418
56MAP2K30.88999690
57AURKA0.88737721
58WNK30.84407425
59TESK20.83837067
60PDK10.83795935
61CDK40.83362915
62NEK90.82063627
63CDK20.80767107
64LATS20.80376203
65MKNK10.79047817
66TYK20.78892083
67TYRO30.78159894
68MATK0.71121639
69VRK10.71004645
70ZAK0.69739470
71PDGFRB0.64972489
72CDK10.64505985
73MAP3K50.63020900
74CSF1R0.62885725
75MELK0.62702295
76STK160.62249072
77MAP3K80.61887421
78STK40.61435422
79RAF10.61313144
80MAP3K10.61086464
81RPS6KB20.59734950
82BMPR1B0.57453029
83JAK30.57403672
84MTOR0.56854514
85EGFR0.56581528
86PRKCI0.56341134
87ALK0.55489928
88CSNK2A20.54968400
89PINK10.54422408
90PBK0.54310154
91PTK2B0.53151731
92INSRR0.52403272
93TAOK10.51787868
94STK380.50294354
95LATS10.49785875
96CSNK2A10.48398896
97SGK10.47979965
98MAP3K90.47163275
99RPS6KA40.46590404
100BRAF0.46513359
101IRAK40.46366766
102CSNK1E0.45230073
103PAK10.45031292
104MAP3K30.44857534
105MAP3K130.44475897
106PAK40.43253611
107BMPR20.41723905
108PRKDC0.38677080
109MARK30.38428388
110CSK0.38169297
111JAK20.38074225
112MAP3K140.37107340
113CSNK1D0.37039331
114NME20.36269276
115CDK60.34693785
116KIT0.34615634
117STK390.33452445
118WNK40.33062527
119STK110.29932105
120PIM10.29802952
121CDK80.27919451
122GSK3B0.27123955
123EIF2AK20.26970175
124ABL20.25746639
125DYRK20.25182467
126WNK10.25019732
127MAPK100.22002496
128TLK10.21766955
129CDK30.21706279
130STK100.21648335
131IGF1R0.21612175
132NEK60.20644700
133MET0.20238795
134MAPKAPK30.20123842
135MAPK140.20057742
136CDK90.20025994
137RPS6KA10.19987927
138SCYL20.19957131
139PRKAA10.19850106
140RET0.19370401
141MAPK80.14115702
142TGFBR10.13777610
143RPS6KA50.13524020
144MAPK10.13194704
145RPS6KB10.12088553
146DYRK1B0.11216523
147AKT10.08086090

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.75959378
2RNA transport_Homo sapiens_hsa030133.84670241
3DNA replication_Homo sapiens_hsa030303.68420786
4Mismatch repair_Homo sapiens_hsa034303.63830450
5Homologous recombination_Homo sapiens_hsa034403.57557388
6Basal transcription factors_Homo sapiens_hsa030223.56569635
7RNA polymerase_Homo sapiens_hsa030203.48903914
8Vitamin B6 metabolism_Homo sapiens_hsa007503.36052218
9Fanconi anemia pathway_Homo sapiens_hsa034603.33002280
10Spliceosome_Homo sapiens_hsa030403.03849635
11Cell cycle_Homo sapiens_hsa041103.00049402
12Proteasome_Homo sapiens_hsa030502.71857579
13Nucleotide excision repair_Homo sapiens_hsa034202.64701099
14mRNA surveillance pathway_Homo sapiens_hsa030152.46554937
15Pyrimidine metabolism_Homo sapiens_hsa002402.21284045
16Base excision repair_Homo sapiens_hsa034102.08150269
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.02771326
18Oocyte meiosis_Homo sapiens_hsa041141.95552995
19RNA degradation_Homo sapiens_hsa030181.93934245
20One carbon pool by folate_Homo sapiens_hsa006701.93372190
21Non-homologous end-joining_Homo sapiens_hsa034501.91499766
22SNARE interactions in vesicular transport_Homo sapiens_hsa041301.84402485
23p53 signaling pathway_Homo sapiens_hsa041151.80776722
24Selenocompound metabolism_Homo sapiens_hsa004501.73196838
25Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.66983035
26Pentose phosphate pathway_Homo sapiens_hsa000301.57856141
27Purine metabolism_Homo sapiens_hsa002301.52421170
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.29762932
29Ribosome_Homo sapiens_hsa030101.28301937
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.26736399
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.24480401
32Dorso-ventral axis formation_Homo sapiens_hsa043201.21493881
33Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.21355047
34Osteoclast differentiation_Homo sapiens_hsa043801.20527959
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.19828866
36Epstein-Barr virus infection_Homo sapiens_hsa051691.17547912
37Staphylococcus aureus infection_Homo sapiens_hsa051501.15136990
38Biosynthesis of amino acids_Homo sapiens_hsa012301.13612226
39Leishmaniasis_Homo sapiens_hsa051401.07528296
40Tuberculosis_Homo sapiens_hsa051521.01845063
41Phagosome_Homo sapiens_hsa041450.93281889
42Pyruvate metabolism_Homo sapiens_hsa006200.93088076
43Glycosaminoglycan degradation_Homo sapiens_hsa005310.92051242
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89828149
45Huntingtons disease_Homo sapiens_hsa050160.87989425
46Antigen processing and presentation_Homo sapiens_hsa046120.87752084
47Toll-like receptor signaling pathway_Homo sapiens_hsa046200.85192224
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80273373
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78612655
50Carbon metabolism_Homo sapiens_hsa012000.73626045
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.73382491
52Lysosome_Homo sapiens_hsa041420.70685811
53Viral carcinogenesis_Homo sapiens_hsa052030.69957890
54B cell receptor signaling pathway_Homo sapiens_hsa046620.68554895
55Herpes simplex infection_Homo sapiens_hsa051680.67720470
56Circadian rhythm_Homo sapiens_hsa047100.67656182
57Endocytosis_Homo sapiens_hsa041440.67524521
58ABC transporters_Homo sapiens_hsa020100.66942030
59Linoleic acid metabolism_Homo sapiens_hsa005910.66841150
60Glycerophospholipid metabolism_Homo sapiens_hsa005640.63996471
61Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63347569
62beta-Alanine metabolism_Homo sapiens_hsa004100.60975119
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.58784115
64N-Glycan biosynthesis_Homo sapiens_hsa005100.57989700
65Shigellosis_Homo sapiens_hsa051310.57652607
66Glutathione metabolism_Homo sapiens_hsa004800.57068293
67alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57064409
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56891284
69Measles_Homo sapiens_hsa051620.56034645
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55256179
71HTLV-I infection_Homo sapiens_hsa051660.54740453
72Toxoplasmosis_Homo sapiens_hsa051450.54609975
73Folate biosynthesis_Homo sapiens_hsa007900.54482888
74Systemic lupus erythematosus_Homo sapiens_hsa053220.54109299
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.52999771
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50135492
77Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50132402
78Prostate cancer_Homo sapiens_hsa052150.49578113
79Jak-STAT signaling pathway_Homo sapiens_hsa046300.49315651
80Glycerolipid metabolism_Homo sapiens_hsa005610.49202794
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49007931
82Fructose and mannose metabolism_Homo sapiens_hsa000510.47759876
83Regulation of autophagy_Homo sapiens_hsa041400.47653496
84Hepatitis B_Homo sapiens_hsa051610.47236173
85Apoptosis_Homo sapiens_hsa042100.47099733
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45189201
87Glucagon signaling pathway_Homo sapiens_hsa049220.43154927
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42717227
89Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.42627183
90Vitamin digestion and absorption_Homo sapiens_hsa049770.42489522
91NF-kappa B signaling pathway_Homo sapiens_hsa040640.42354451
92T cell receptor signaling pathway_Homo sapiens_hsa046600.41851980
93TGF-beta signaling pathway_Homo sapiens_hsa043500.38655889
94Phenylalanine metabolism_Homo sapiens_hsa003600.38385986
95Propanoate metabolism_Homo sapiens_hsa006400.38027724
96Acute myeloid leukemia_Homo sapiens_hsa052210.36360832
97Fatty acid biosynthesis_Homo sapiens_hsa000610.35920899
98Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.32929588
99TNF signaling pathway_Homo sapiens_hsa046680.32770816
100Hippo signaling pathway_Homo sapiens_hsa043900.31710633
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.30498200
102Collecting duct acid secretion_Homo sapiens_hsa049660.29674860
103Type II diabetes mellitus_Homo sapiens_hsa049300.29603918
104Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.29155429
105Choline metabolism in cancer_Homo sapiens_hsa052310.29084681
106Metabolic pathways_Homo sapiens_hsa011000.27928711
107Tight junction_Homo sapiens_hsa045300.26828587
108Malaria_Homo sapiens_hsa051440.26513858
109MicroRNAs in cancer_Homo sapiens_hsa052060.26086002
110ErbB signaling pathway_Homo sapiens_hsa040120.24711273
111Salmonella infection_Homo sapiens_hsa051320.24158206
112mTOR signaling pathway_Homo sapiens_hsa041500.22745563
113MAPK signaling pathway_Homo sapiens_hsa040100.22254139
114Chemokine signaling pathway_Homo sapiens_hsa040620.21695550
115Non-small cell lung cancer_Homo sapiens_hsa052230.21581337
116Hematopoietic cell lineage_Homo sapiens_hsa046400.21119787
117Small cell lung cancer_Homo sapiens_hsa052220.20958367
118Hedgehog signaling pathway_Homo sapiens_hsa043400.20291629
119Influenza A_Homo sapiens_hsa051640.18357235
120Hepatitis C_Homo sapiens_hsa051600.17473699
121Olfactory transduction_Homo sapiens_hsa047400.17088560
122Central carbon metabolism in cancer_Homo sapiens_hsa052300.16880350
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.16336088
124Legionellosis_Homo sapiens_hsa051340.14575797
125Arachidonic acid metabolism_Homo sapiens_hsa005900.13551689
126Thyroid cancer_Homo sapiens_hsa052160.13220528
127Basal cell carcinoma_Homo sapiens_hsa052170.11037165
128Sulfur relay system_Homo sapiens_hsa041220.10626968
129Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.10025950
130HIF-1 signaling pathway_Homo sapiens_hsa040660.08528419
131Fat digestion and absorption_Homo sapiens_hsa049750.08095780
132Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.08030146
133Inositol phosphate metabolism_Homo sapiens_hsa005620.07564315
134Ether lipid metabolism_Homo sapiens_hsa005650.07223010
135Mineral absorption_Homo sapiens_hsa049780.06127019
136Longevity regulating pathway - mammal_Homo sapiens_hsa042110.05608180
137Adherens junction_Homo sapiens_hsa045200.04350329
138Lysine degradation_Homo sapiens_hsa003100.03704439
139Renin-angiotensin system_Homo sapiens_hsa046140.03534002
140Arginine and proline metabolism_Homo sapiens_hsa003300.03488931
141Notch signaling pathway_Homo sapiens_hsa043300.03329010
142Alcoholism_Homo sapiens_hsa050340.03316727
143Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.03081672
144Wnt signaling pathway_Homo sapiens_hsa043100.02540197
145Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.02177793
146FoxO signaling pathway_Homo sapiens_hsa040680.01961072
1472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.01944014

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