HOPX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts. Studies in mice suggest that this protein may interact with serum response factor (SRF) and modulate SRF-dependent cardiac-specific gene expression and cardiac development. Multiple alternatively spliced transcript variants have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.81964858
2keratinization (GO:0031424)6.18440171
3regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.72368529
4surfactant homeostasis (GO:0043129)5.24585585
5negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.78258239
6bundle of His cell to Purkinje myocyte communication (GO:0086069)4.77235004
7negative regulation of potassium ion transmembrane transport (GO:1901380)4.56056401
8sarcomere organization (GO:0045214)4.44629003
9chemical homeostasis within a tissue (GO:0048875)4.40285892
10establishment of skin barrier (GO:0061436)4.33168611
11ventricular cardiac muscle cell action potential (GO:0086005)4.30614850
12cardiac myofibril assembly (GO:0055003)4.29910587
13regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.24059265
14positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.03096635
15regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.98292689
16desmosome organization (GO:0002934)3.97453847
17phosphatidylinositol acyl-chain remodeling (GO:0036149)3.90851151
18regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.82216204
19cardiac muscle contraction (GO:0060048)3.76931063
20regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.73931797
21cell communication involved in cardiac conduction (GO:0086065)3.73916506
22myofibril assembly (GO:0030239)3.73321210
23cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.71342702
24C4-dicarboxylate transport (GO:0015740)3.61011146
25mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.59346398
26auditory behavior (GO:0031223)3.58887051
27phosphatidylserine acyl-chain remodeling (GO:0036150)3.54901048
28activated T cell proliferation (GO:0050798)3.53123873
29energy coupled proton transport, down electrochemical gradient (GO:0015985)3.52462767
30ATP synthesis coupled proton transport (GO:0015986)3.52462767
31regulation of B cell receptor signaling pathway (GO:0050855)3.50123451
32negative regulation by host of viral transcription (GO:0043922)3.49175539
33regulation of lymphocyte chemotaxis (GO:1901623)3.47352530
34positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.46505953
35T cell migration (GO:0072678)3.41939382
36neurotransmitter uptake (GO:0001504)3.40794350
37heart trabecula formation (GO:0060347)3.40390234
38respiratory electron transport chain (GO:0022904)3.39698540
39mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.37586847
40regulation of relaxation of muscle (GO:1901077)3.33763841
41regulation of cardioblast differentiation (GO:0051890)3.32910200
42positive regulation of interleukin-8 secretion (GO:2000484)3.32578566
43regulation of actin filament-based movement (GO:1903115)3.31968580
44electron transport chain (GO:0022900)3.30663708
45membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.27381825
46regulation of T cell receptor signaling pathway (GO:0050856)3.26161984
47negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.25007970
48ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.23795420
49tricarboxylic acid cycle (GO:0006099)3.21581525
50phosphatidylcholine acyl-chain remodeling (GO:0036151)3.19416386
51cell communication by electrical coupling (GO:0010644)3.14061333
52positive regulation of natural killer cell mediated immunity (GO:0002717)3.13813795
53regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.13721576
54fatty acid transmembrane transport (GO:1902001)3.13164800
55cardiac muscle tissue morphogenesis (GO:0055008)3.12632952
56regulation of water loss via skin (GO:0033561)3.11034227
57cellular response to interleukin-15 (GO:0071350)3.09813928
58cardiac muscle cell development (GO:0055013)3.08391458
59postsynaptic membrane organization (GO:0001941)3.08191891
60regulation of membrane repolarization (GO:0060306)3.07686859
61positive regulation of calcium-mediated signaling (GO:0050850)3.07385780
62regulation of endothelial cell differentiation (GO:0045601)3.07135890
63positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.06982735
64actomyosin structure organization (GO:0031032)3.06848067
65eosinophil chemotaxis (GO:0048245)3.06440060
66regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.05599012
67actin-myosin filament sliding (GO:0033275)3.05377542
68muscle filament sliding (GO:0030049)3.05377542
69plasma membrane repair (GO:0001778)3.04456220
70mechanosensory behavior (GO:0007638)3.04327846
71positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.04003212
72phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.03223777
73aggressive behavior (GO:0002118)3.02889663
74negative regulation of T cell receptor signaling pathway (GO:0050860)3.02648707
75carnitine shuttle (GO:0006853)3.00576967
76membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.98929130
77positive regulation of endothelial cell differentiation (GO:0045603)2.97501662
78relaxation of cardiac muscle (GO:0055119)2.97497583
79macrophage chemotaxis (GO:0048246)2.96710022
80positive regulation of lymphocyte migration (GO:2000403)2.93312549
81fatty acid beta-oxidation (GO:0006635)2.92105357
82regulation of striated muscle contraction (GO:0006942)2.89390881
83regulation of calcium-mediated signaling (GO:0050848)2.89214306
84cardiac cell development (GO:0055006)2.89157749
85positive T cell selection (GO:0043368)2.88994385
86cellular response to nitric oxide (GO:0071732)2.88779131
87regulation of heart rate by cardiac conduction (GO:0086091)2.88309615
88cardiac muscle hypertrophy (GO:0003300)2.87823379
89cardiac muscle cell action potential involved in contraction (GO:0086002)2.87767854
90pyrimidine nucleoside catabolic process (GO:0046135)2.86502372
91regulation of the force of heart contraction (GO:0002026)2.85721744
92adult heart development (GO:0007512)2.85617651
93regulation of vasculogenesis (GO:2001212)2.84909613
94cellular response to reactive nitrogen species (GO:1902170)2.83306163
95cardiac muscle cell action potential (GO:0086001)2.80787468
96muscle tissue morphogenesis (GO:0060415)2.78990341
97cardiac conduction (GO:0061337)2.77755928
98striated muscle hypertrophy (GO:0014897)2.77269914
99cytidine metabolic process (GO:0046087)2.76235283
100cytidine catabolic process (GO:0006216)2.76235283
101cytidine deamination (GO:0009972)2.76235283
102regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.75260499
103eosinophil migration (GO:0072677)2.74842062
104regulation of cell communication by electrical coupling (GO:0010649)2.74749103
105regulation of sarcomere organization (GO:0060297)2.74653193
106regulation of regulatory T cell differentiation (GO:0045589)2.74288885
107L-amino acid import (GO:0043092)2.71576798
108membrane repolarization during action potential (GO:0086011)2.70558416
109regulation of heart rate (GO:0002027)2.69986438
110striated muscle contraction (GO:0006941)2.69627134
111negative regulation of T cell apoptotic process (GO:0070233)2.69470421
112negative regulation of protein localization to cell surface (GO:2000009)2.69074110
113gamma-aminobutyric acid transport (GO:0015812)2.68061411
114positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.67442066
115regulation of cardiac muscle contraction (GO:0055117)2.66347830
116potassium ion export (GO:0071435)2.66195429
117regulation of B cell differentiation (GO:0045577)2.66121747
118regulation of activation of Janus kinase activity (GO:0010533)2.64447362
119antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.63325382
120regulation of T cell chemotaxis (GO:0010819)2.60885942
121positive regulation of T cell chemotaxis (GO:0010820)2.60885942
122actin-mediated cell contraction (GO:0070252)2.60853153
1232-oxoglutarate metabolic process (GO:0006103)2.59745838
124lymphocyte chemotaxis (GO:0048247)2.58876947
125positive regulation of potassium ion transmembrane transport (GO:1901381)2.58346288
126fatty acid catabolic process (GO:0009062)2.57369942
127response to nitric oxide (GO:0071731)2.57047978
128regulation of cardiac muscle cell contraction (GO:0086004)2.54996791
129positive thymic T cell selection (GO:0045059)2.54807705
130hormone catabolic process (GO:0042447)2.54762988
131lysine catabolic process (GO:0006554)2.54532800
132lysine metabolic process (GO:0006553)2.54532800
133regulation of skeletal muscle contraction (GO:0014819)2.54336855
134regulation of natural killer cell mediated immunity (GO:0002715)2.54277955
135regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.54277955
136positive regulation of monocyte chemotaxis (GO:0090026)2.53643649
137lipid oxidation (GO:0034440)2.53558364
138negative T cell selection (GO:0043383)2.52886612
139neuron cell-cell adhesion (GO:0007158)2.52543580
140fatty acid oxidation (GO:0019395)2.52389627
141negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.51424318
142one-carbon compound transport (GO:0019755)2.49483609
143muscle hypertrophy (GO:0014896)2.49466292
144sarcoplasmic reticulum calcium ion transport (GO:0070296)2.49231233
145long-chain fatty acid biosynthetic process (GO:0042759)2.48795946
146hemidesmosome assembly (GO:0031581)2.47668051
147regulation of interleukin-8 secretion (GO:2000482)2.47565792
148aspartate family amino acid catabolic process (GO:0009068)2.46646741
149ethanol metabolic process (GO:0006067)2.46545062
150detection of light stimulus involved in sensory perception (GO:0050962)2.45795454
151detection of light stimulus involved in visual perception (GO:0050908)2.45795454
152fatty acid elongation (GO:0030497)2.45364850
153membrane repolarization (GO:0086009)2.44636824
154positive regulation of defense response to virus by host (GO:0002230)2.44521625
155multicellular organismal water homeostasis (GO:0050891)2.44052990
156positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.42787728
157heart contraction (GO:0060047)2.42203880
158heart process (GO:0003015)2.42203880
159cellular potassium ion homeostasis (GO:0030007)2.41439156
160ethanol oxidation (GO:0006069)2.41274449
161negative regulation of viral genome replication (GO:0045071)2.40782437
162short-chain fatty acid metabolic process (GO:0046459)2.40631757
163calcium-mediated signaling using intracellular calcium source (GO:0035584)2.40536133
164DNA demethylation (GO:0080111)2.40326761
165cellular ketone body metabolic process (GO:0046950)2.39635862
166phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.38858024
167positive regulation of B cell differentiation (GO:0045579)2.38310949
168keratinocyte differentiation (GO:0030216)2.38127280
169response to auditory stimulus (GO:0010996)2.38115977
170presynaptic membrane assembly (GO:0097105)2.37942732
171cell morphogenesis involved in neuron differentiation (GO:0048667)2.37843684
172response to interleukin-15 (GO:0070672)2.37641137
173pyrimidine ribonucleoside catabolic process (GO:0046133)2.36100306
174blood vessel maturation (GO:0001955)2.35898497
175lymphangiogenesis (GO:0001946)2.35311759
176regulation of female receptivity (GO:0045924)2.35169476
177neuronal action potential propagation (GO:0019227)2.34402142
178regulation of leukocyte mediated cytotoxicity (GO:0001910)2.34046842
179actin nucleation (GO:0045010)2.32630507
180negative regulation of mast cell activation (GO:0033004)2.32485809
181regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.31904399
182detection of calcium ion (GO:0005513)2.31873739
183positive regulation of cell killing (GO:0031343)2.30802597
184lymphocyte migration (GO:0072676)2.30546326
185positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.29809381
186water homeostasis (GO:0030104)2.29471941
187acidic amino acid transport (GO:0015800)2.27012447
188positive regulation of amino acid transport (GO:0051957)2.26993193
189Arp2/3 complex-mediated actin nucleation (GO:0034314)2.26782797
190hair cycle (GO:0042633)2.26451902
191molting cycle (GO:0042303)2.26451902
192potassium ion import (GO:0010107)2.24242808
193ionotropic glutamate receptor signaling pathway (GO:0035235)2.22568657
194primary amino compound metabolic process (GO:1901160)2.21633603
195synaptic vesicle exocytosis (GO:0016079)2.20603235

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.33305444
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.75945798
3GATA1_22025678_ChIP-Seq_K562_Human2.65102622
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.59939632
5GBX2_23144817_ChIP-Seq_PC3_Human2.56015478
6EP300_21415370_ChIP-Seq_HL-1_Mouse2.50269779
7* RXR_22158963_ChIP-Seq_LIVER_Mouse2.45430522
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.43618836
9* LXR_22158963_ChIP-Seq_LIVER_Mouse2.38795720
10CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.37802411
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.32561911
12* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.30485303
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.29671021
14CDX2_19796622_ChIP-Seq_MESCs_Mouse2.26034724
15FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.23518722
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.20878549
17IGF1R_20145208_ChIP-Seq_DFB_Human2.16362564
18ESR1_20079471_ChIP-ChIP_T-47D_Human2.13768700
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.04951378
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.04699289
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.04645503
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.02341164
23ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.97556788
24ESR2_21235772_ChIP-Seq_MCF-7_Human1.94944772
25TRIM28_21343339_ChIP-Seq_HEK293_Human1.94663790
26* TBX20_22328084_ChIP-Seq_HEART_Mouse1.94417416
27* TBX20_22080862_ChIP-Seq_HEART_Mouse1.94417416
28NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.89077313
29VDR_22108803_ChIP-Seq_LS180_Human1.86006542
30SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.85632658
31ZNF263_19887448_ChIP-Seq_K562_Human1.82809794
32CLOCK_20551151_ChIP-Seq_293T_Human1.80503902
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.80314760
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.80204693
35E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.78853379
36ZNF274_21170338_ChIP-Seq_K562_Hela1.76559061
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.66122929
38SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.61825394
39TAF15_26573619_Chip-Seq_HEK293_Human1.58361445
40TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53066220
41AR_21572438_ChIP-Seq_LNCaP_Human1.52837920
42* P300_19829295_ChIP-Seq_ESCs_Human1.52509668
43BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.51231128
44TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.50481371
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.47904400
46LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.46411300
47MTF2_20144788_ChIP-Seq_MESCs_Mouse1.46140637
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44379827
49SMAD4_21799915_ChIP-Seq_A2780_Human1.43216909
50GATA2_21666600_ChIP-Seq_HMVEC_Human1.42263118
51SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.39961714
52FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.38161671
53RNF2_18974828_ChIP-Seq_MESCs_Mouse1.36517751
54EZH2_18974828_ChIP-Seq_MESCs_Mouse1.36517751
55HTT_18923047_ChIP-ChIP_STHdh_Human1.36391146
56* REST_21632747_ChIP-Seq_MESCs_Mouse1.35645559
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.34881588
58EZH2_22144423_ChIP-Seq_EOC_Human1.34583707
59ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.33267036
60EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.32649042
61FUS_26573619_Chip-Seq_HEK293_Human1.31192831
62PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.30504608
63BCAT_22108803_ChIP-Seq_LS180_Human1.29800566
64SOX9_24532713_ChIP-Seq_HFSC_Mouse1.29674909
65* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.29324640
66PRDM14_20953172_ChIP-Seq_ESCs_Human1.28015450
67ER_23166858_ChIP-Seq_MCF-7_Human1.27743812
68CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.27470231
69RXR_22108803_ChIP-Seq_LS180_Human1.27411441
70TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.27379345
71AR_25329375_ChIP-Seq_VCAP_Human1.25826721
72IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.24571881
73SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22429846
74SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.22410680
75FOXO3_23340844_ChIP-Seq_DLD1_Human1.21501631
76PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21232892
77STAT6_21828071_ChIP-Seq_BEAS2B_Human1.21138661
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20421515
79PPAR_26484153_Chip-Seq_NCI-H1993_Human1.20147346
80EED_16625203_ChIP-ChIP_MESCs_Mouse1.20038553
81TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19638051
82GATA3_26560356_Chip-Seq_TH2_Human1.19018406
83* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18451885
84SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18284393
85* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.17809714
86SMAD3_21741376_ChIP-Seq_EPCs_Human1.17184566
87SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.16757197
88IRF8_21731497_ChIP-ChIP_J774_Mouse1.16664651
89EZH2_27294783_Chip-Seq_NPCs_Mouse1.15769099
90ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15260976
91BP1_19119308_ChIP-ChIP_Hs578T_Human1.15013869
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.13920262
93CBP_20019798_ChIP-Seq_JUKART_Human1.13920262
94SOX2_20726797_ChIP-Seq_SW620_Human1.13847926
95SOX2_19829295_ChIP-Seq_ESCs_Human1.13591962
96NANOG_19829295_ChIP-Seq_ESCs_Human1.13591962
97SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13400116
98EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12917449
99HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.12032155
100EZH2_27294783_Chip-Seq_ESCs_Mouse1.11902789
101TCF4_22108803_ChIP-Seq_LS180_Human1.11632434
102* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09896624
103ESR1_21235772_ChIP-Seq_MCF-7_Human1.08437836
104SMAD_19615063_ChIP-ChIP_OVARY_Human1.08434595
105* CJUN_26792858_Chip-Seq_BT549_Human1.07368234
106SOX2_27498859_Chip-Seq_STOMACH_Mouse1.07365086
107OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07055432
108NFE2_27457419_Chip-Seq_LIVER_Mouse1.06425185
109FOXA2_19822575_ChIP-Seq_HepG2_Human1.06343532
110MYB_26560356_Chip-Seq_TH2_Human1.06129958
111PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05849618
112UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05582138
113NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05455383
114EWS_26573619_Chip-Seq_HEK293_Human1.05311560
115DROSHA_22980978_ChIP-Seq_HELA_Human1.04968437
116GATA3_27048872_Chip-Seq_THYMUS_Human1.04622420
117TAF2_19829295_ChIP-Seq_ESCs_Human1.04495475
118TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04253631
119* STAT3_23295773_ChIP-Seq_U87_Human1.04083312
120TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.04068276
121KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03611969
122FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03380103
123FOXA1_25329375_ChIP-Seq_VCAP_Human1.03380103
124AHR_22903824_ChIP-Seq_MCF-7_Human1.02623894
125* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.02484873
126NRF2_20460467_ChIP-Seq_MEFs_Mouse1.02427082
127NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.02427082
128JARID2_20064375_ChIP-Seq_MESCs_Mouse1.02169181
129SUZ12_27294783_Chip-Seq_ESCs_Mouse1.02074451
130AR_20517297_ChIP-Seq_VCAP_Human1.01803115
131CDX2_20551321_ChIP-Seq_CACO-2_Human1.01784921
132MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01767513
133GATA1_19941826_ChIP-Seq_K562_Human1.00628112
134RACK7_27058665_Chip-Seq_MCF-7_Human1.00101119
135TCF4_23295773_ChIP-Seq_U87_Human0.99585239
136KDM2B_26808549_Chip-Seq_SUP-B15_Human0.98886186
137* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.98775402
138CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97337792
139GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.96813270
140LXR_22292898_ChIP-Seq_THP-1_Human0.96751617
141EGR1_23403033_ChIP-Seq_LIVER_Mouse0.96508561
142FLI1_21867929_ChIP-Seq_TH2_Mouse0.96455675
143NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96144091
144RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.95439163
145STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.95335427
146SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.95304534
147RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94694704
148SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.94579952
149MYC_19829295_ChIP-Seq_ESCs_Human0.94496211
150PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.93069414
151PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92839616
152GATA3_21878914_ChIP-Seq_MCF-7_Human0.92821047
153TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92383624
154GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.92059723
155NANOG_18555785_Chip-Seq_ESCs_Mouse0.91707467
156EZH2_27304074_Chip-Seq_ESCs_Mouse0.90333459
157* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.88053406
158SMAD4_21741376_ChIP-Seq_HESCs_Human0.87389537
159* TP63_23658742_ChIP-Seq_EP156T_Human0.87190907
160DNAJC2_21179169_ChIP-ChIP_NT2_Human0.86672117
161RUNX1_27514584_Chip-Seq_MCF-7_Human0.86375669
162TP53_18474530_ChIP-ChIP_U2OS_Human0.86316506
163SMAD3_21741376_ChIP-Seq_HESCs_Human0.85788934
164CTCF_27219007_Chip-Seq_Bcells_Human0.85587538
165* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.85159896
166RNF2_27304074_Chip-Seq_ESCs_Mouse0.84992040
167ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84216720
168ARNT_22903824_ChIP-Seq_MCF-7_Human0.84075562
169TP63_22573176_ChIP-Seq_HFKS_Human0.83181028
170EGR1_19032775_ChIP-ChIP_M12_Human0.82943739
171KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.82930390
172GATA2_19941826_ChIP-Seq_K562_Human0.82624345
173KDM2B_26808549_Chip-Seq_K562_Human0.80110901
174GATA4_25053715_ChIP-Seq_YYC3_Human0.79664464
175IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.77435168
176PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.76981070
177* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.76826428
178ERG_21242973_ChIP-ChIP_JURKAT_Human0.76122102
179PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.75560136
180RUNX_20019798_ChIP-Seq_JUKART_Human0.75377902
181SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.75191525

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.49860736
2MP0004084_abnormal_cardiac_muscle4.41583353
3MP0005671_abnormal_response_to3.58224336
4MP0004215_abnormal_myocardial_fiber3.43198545
5MP0004036_abnormal_muscle_relaxation3.27584835
6MP0003880_abnormal_central_pattern2.96886003
7MP0000751_myopathy2.91806317
8MP0010368_abnormal_lymphatic_system2.82573048
9MP0005330_cardiomyopathy2.73275973
10MP0001968_abnormal_touch/_nociception2.70561138
11MP0004782_abnormal_surfactant_physiolog2.60132226
12MP0002138_abnormal_hepatobiliary_system2.48867877
13MP0001984_abnormal_olfaction2.48168879
14MP0002139_abnormal_hepatobiliary_system2.47066318
15* MP0002972_abnormal_cardiac_muscle2.46417867
16MP0002736_abnormal_nociception_after2.46033867
17MP0001501_abnormal_sleep_pattern2.44499284
18MP0005083_abnormal_biliary_tract2.40748702
19MP0003011_delayed_dark_adaptation2.40473228
20MP0005085_abnormal_gallbladder_physiolo2.38065932
21MP0003646_muscle_fatigue2.33886726
22MP0006138_congestive_heart_failure2.32719592
23MP0001879_abnormal_lymphatic_vessel2.24302254
24* MP0005385_cardiovascular_system_phenoty2.19744342
25* MP0001544_abnormal_cardiovascular_syste2.19744342
26MP0000569_abnormal_digit_pigmentation2.18635429
27MP0008775_abnormal_heart_ventricle2.17125300
28MP0009745_abnormal_behavioral_response2.17034217
29MP0008875_abnormal_xenobiotic_pharmacok2.16137779
30MP0003828_pulmonary_edema2.11036559
31MP0000749_muscle_degeneration2.08708080
32MP0004130_abnormal_muscle_cell2.07286109
33MP0009046_muscle_twitch2.05453334
34MP0005167_abnormal_blood-brain_barrier2.02891440
35MP0001958_emphysema2.02616163
36* MP0003137_abnormal_impulse_conducting1.98698463
37MP0004484_altered_response_of1.97555089
38MP0004885_abnormal_endolymph1.97305729
39MP0005360_urolithiasis1.94883510
40MP0004859_abnormal_synaptic_plasticity1.89653437
41MP0002064_seizures1.86844186
42* MP0004087_abnormal_muscle_fiber1.86663711
43MP0004085_abnormal_heartbeat1.85645741
44MP0001486_abnormal_startle_reflex1.85394213
45MP0005551_abnormal_eye_electrophysiolog1.85386098
46MP0002095_abnormal_skin_pigmentation1.85144085
47MP0002272_abnormal_nervous_system1.82607034
48MP0003635_abnormal_synaptic_transmissio1.79175086
49MP0005646_abnormal_pituitary_gland1.77057721
50* MP0005620_abnormal_muscle_contractility1.71239658
51* MP0010630_abnormal_cardiac_muscle1.71098078
52MP0005174_abnormal_tail_pigmentation1.69446960
53MP0004510_myositis1.65196065
54MP0002638_abnormal_pupillary_reflex1.62933111
55MP0001986_abnormal_taste_sensitivity1.62446299
56MP0001502_abnormal_circadian_rhythm1.62191883
57MP0006072_abnormal_retinal_apoptosis1.56206549
58MP0006082_CNS_inflammation1.56168833
59MP0002796_impaired_skin_barrier1.55619822
60MP0002063_abnormal_learning/memory/cond1.55339108
61MP0003763_abnormal_thymus_physiology1.54704758
62MP0001835_abnormal_antigen_presentation1.54132935
63MP0002572_abnormal_emotion/affect_behav1.53019485
64MP0001905_abnormal_dopamine_level1.52554297
65MP0005423_abnormal_somatic_nervous1.52409668
66MP0002733_abnormal_thermal_nociception1.51094877
67MP0003191_abnormal_cellular_cholesterol1.51075953
68MP0003950_abnormal_plasma_membrane1.51044151
69MP0002148_abnormal_hypersensitivity_rea1.50876743
70MP0009785_altered_susceptibility_to1.47897408
71MP0008569_lethality_at_weaning1.47331958
72MP0001188_hyperpigmentation1.45910162
73MP0005365_abnormal_bile_salt1.42392213
74MP0000343_altered_response_to1.41205839
75MP0005253_abnormal_eye_physiology1.40451625
76MP0001970_abnormal_pain_threshold1.39500961
77MP0005165_increased_susceptibility_to1.37369690
78MP0003045_fibrosis1.37068448
79MP0006276_abnormal_autonomic_nervous1.34596956
80MP0003705_abnormal_hypodermis_morpholog1.34182328
81MP0001440_abnormal_grooming_behavior1.33754474
82MP0005000_abnormal_immune_tolerance1.33523585
83MP0003566_abnormal_cell_adhesion1.32248077
84MP0004272_abnormal_basement_membrane1.28303464
85MP0000750_abnormal_muscle_regeneration1.27457887
86MP0000015_abnormal_ear_pigmentation1.27113201
87MP0006036_abnormal_mitochondrial_physio1.27098801
88MP0004270_analgesia1.25348329
89MP0002876_abnormal_thyroid_physiology1.25190531
90MP0001800_abnormal_humoral_immune1.24535967
91MP0001790_abnormal_immune_system1.24420944
92MP0005387_immune_system_phenotype1.24420944
93MP0002127_abnormal_cardiovascular_syste1.22421390
94MP0004947_skin_inflammation1.21022576
95MP0009840_abnormal_foam_cell1.19515829
96MP0005025_abnormal_response_to1.19468383
97MP0002420_abnormal_adaptive_immunity1.19314038
98MP0003252_abnormal_bile_duct1.18145981
99MP0003633_abnormal_nervous_system1.16462094
100MP0002723_abnormal_immune_serum1.16292046
101MP0002067_abnormal_sensory_capabilities1.15173613
102MP0001819_abnormal_immune_cell1.13467521
103MP0002295_abnormal_pulmonary_circulatio1.13091968
104MP0005275_abnormal_skin_tensile1.12319769
105MP0002133_abnormal_respiratory_system1.11640207
106MP0005388_respiratory_system_phenotype1.11640207
107MP0008872_abnormal_physiological_respon1.10706569
108MP0005332_abnormal_amino_acid1.10681438
109MP0000920_abnormal_myelination1.10563175
110MP0009780_abnormal_chondrocyte_physiolo1.10284526
111MP0000383_abnormal_hair_follicle1.10128403
112MP0009333_abnormal_splenocyte_physiolog1.09870339
113MP0002132_abnormal_respiratory_system1.09569375
114* MP0002106_abnormal_muscle_physiology1.08544048
115MP0005075_abnormal_melanosome_morpholog1.06994115
116MP0003866_abnormal_defecation1.06736896
117MP0005645_abnormal_hypothalamus_physiol1.05952243
118MP0010329_abnormal_lipoprotein_level1.05269908
119MP0010678_abnormal_skin_adnexa1.04049547
120MP0004742_abnormal_vestibular_system1.03909023
121MP0005501_abnormal_skin_physiology1.03847948
122MP0010234_abnormal_vibrissa_follicle1.03371920
123MP0002118_abnormal_lipid_homeostasis1.03175353
124MP0000579_abnormal_nail_morphology1.02057265
125MP0003806_abnormal_nucleotide_metabolis1.01238037
126MP0004924_abnormal_behavior0.99646581
127MP0005386_behavior/neurological_phenoty0.99646581
128MP0000685_abnormal_immune_system0.99117357
129MP0004381_abnormal_hair_follicle0.97682295
130MP0000604_amyloidosis0.96490524
131MP0004858_abnormal_nervous_system0.96485478
132MP0002734_abnormal_mechanical_nocicepti0.95841217
133MP0004185_abnormal_adipocyte_glucose0.95796310
134MP0002557_abnormal_social/conspecific_i0.95553863
135MP0002229_neurodegeneration0.95475631
136MP0002822_catalepsy0.94407733
137MP0002269_muscular_atrophy0.93496836
138MP0000647_abnormal_sebaceous_gland0.91542094
139MP0009384_cardiac_valve_regurgitation0.91524168
140MP0003329_amyloid_beta_deposits0.91389366
141MP0003279_aneurysm0.91258936
142MP0001853_heart_inflammation0.90755416
143MP0002332_abnormal_exercise_endurance0.89963383
144MP0010386_abnormal_urinary_bladder0.89646004
145MP0004147_increased_porphyrin_level0.88996550
146MP0000230_abnormal_systemic_arterial0.88677665
147MP0010771_integument_phenotype0.88393241
148MP0002452_abnormal_antigen_presenting0.87954459
149MP0001485_abnormal_pinna_reflex0.87545911
150MP0009643_abnormal_urine_homeostasis0.87234449
151MP0003221_abnormal_cardiomyocyte_apopto0.85756919
152MP0000767_abnormal_smooth_muscle0.84374989
153MP0000747_muscle_weakness0.84121094
154MP0000465_gastrointestinal_hemorrhage0.83527770
155MP0005595_abnormal_vascular_smooth0.83223852
156MP0000249_abnormal_blood_vessel0.82017719
157MP0003631_nervous_system_phenotype0.81170244
158* MP0002128_abnormal_blood_circulation0.80932697
159MP0002166_altered_tumor_susceptibility0.80259495
160* MP0005369_muscle_phenotype0.79982571
161MP0000427_abnormal_hair_cycle0.79866844
162MP0000372_irregular_coat_pigmentation0.79815786
163MP0005584_abnormal_enzyme/coenzyme_acti0.79652376
164MP0005451_abnormal_body_composition0.79185171
165MP0005319_abnormal_enzyme/_coenzyme0.78291903
166MP0003724_increased_susceptibility_to0.76904518
167MP0009379_abnormal_foot_pigmentation0.76437775
168MP0008004_abnormal_stomach_pH0.76182159
169MP0000759_abnormal_skeletal_muscle0.76078376
170MP0005166_decreased_susceptibility_to0.76054021
171MP0005666_abnormal_adipose_tissue0.75950071
172MP0002909_abnormal_adrenal_gland0.73089336
173MP0008995_early_reproductive_senescence0.72460810
174MP0009764_decreased_sensitivity_to0.71859961
175MP0001666_abnormal_nutrient_absorption0.71209597
176MP0003690_abnormal_glial_cell0.70619324
177MP0004145_abnormal_muscle_electrophysio0.69187002
178* MP0000266_abnormal_heart_morphology0.66324570
179MP0002735_abnormal_chemical_nociception0.66031349
180MP0003075_altered_response_to0.65814104
181MP0001765_abnormal_ion_homeostasis0.64657119
182MP0003300_gastrointestinal_ulcer0.63411391
183MP0002234_abnormal_pharynx_morphology0.61522978
184MP0004043_abnormal_pH_regulation0.59442557
185MP0004883_abnormal_blood_vessel0.55621787
186MP0000609_abnormal_liver_physiology0.55200317

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)6.48656234
2Ventricular tachycardia (HP:0004756)5.28686176
3Right ventricular cardiomyopathy (HP:0011663)5.07218120
4Hemiplegia (HP:0002301)4.72535133
5Syncope (HP:0001279)4.57616945
6Hemiparesis (HP:0001269)4.55065806
7Ventricular fibrillation (HP:0001663)4.49481754
8Atrial fibrillation (HP:0005110)4.29977519
9Increased IgE level (HP:0003212)4.27353275
10Erythroderma (HP:0001019)4.17281186
11Hyporeflexia of lower limbs (HP:0002600)4.04612265
12Primary atrial arrhythmia (HP:0001692)4.03835859
13Focal motor seizures (HP:0011153)3.86792482
14Calf muscle hypertrophy (HP:0008981)3.86446215
15Supraventricular tachycardia (HP:0004755)3.83415379
16Supraventricular arrhythmia (HP:0005115)3.78279001
17Exercise-induced myalgia (HP:0003738)3.70712426
18Polycythemia (HP:0001901)3.69025207
19Abnormality of binocular vision (HP:0011514)3.63163870
20Diplopia (HP:0000651)3.63163870
21Prolonged QT interval (HP:0001657)3.60863101
22Palmar hyperkeratosis (HP:0010765)3.55747261
23Palmoplantar hyperkeratosis (HP:0000972)3.55323903
24T lymphocytopenia (HP:0005403)3.51447324
25Palpitations (HP:0001962)3.51039947
26Muscle hypertrophy of the lower extremities (HP:0008968)3.46464000
27Lipoatrophy (HP:0100578)3.44235737
28Ventricular arrhythmia (HP:0004308)3.42368875
29Febrile seizures (HP:0002373)3.38530210
30Congenital stationary night blindness (HP:0007642)3.38021915
31Exercise-induced muscle cramps (HP:0003710)3.37510036
32Abnormality of T cell number (HP:0011839)3.34572421
33Myoglobinuria (HP:0002913)3.30530519
34Parakeratosis (HP:0001036)3.24899655
35Deep venous thrombosis (HP:0002625)3.23960488
36Erythema (HP:0010783)3.18717491
37Bundle branch block (HP:0011710)3.18107768
38Muscle fiber splitting (HP:0003555)3.17664331
39Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.15612029
40Autoimmune hemolytic anemia (HP:0001890)3.12292122
41Interstitial pulmonary disease (HP:0006530)3.11500598
42Abnormality of the calf musculature (HP:0001430)3.09167701
43Cerebral hemorrhage (HP:0001342)3.08197657
44Dilated cardiomyopathy (HP:0001644)3.05156959
45Elevated erythrocyte sedimentation rate (HP:0003565)2.98126287
46Hypoglycemic coma (HP:0001325)2.98121950
47Hypoproteinemia (HP:0003075)2.97645410
48Asymmetric septal hypertrophy (HP:0001670)2.95526212
49Hyperactive renin-angiotensin system (HP:0000841)2.95448401
50Atrioventricular block (HP:0001678)2.94642462
51Heart block (HP:0012722)2.94628630
52Congenital ichthyosiform erythroderma (HP:0007431)2.93332937
53Conjunctival hamartoma (HP:0100780)2.91401024
54Myotonia (HP:0002486)2.91174564
55Abnormality of the axillary hair (HP:0100134)2.88641095
56Abnormality of secondary sexual hair (HP:0009888)2.88641095
57Abnormality of the left ventricular outflow tract (HP:0011103)2.84731539
58Subaortic stenosis (HP:0001682)2.84731539
59Decreased electroretinogram (ERG) amplitude (HP:0000654)2.81561667
60Abnormal atrioventricular conduction (HP:0005150)2.78638672
61Decreased central vision (HP:0007663)2.72276747
62Abnormality of T cells (HP:0002843)2.71342022
63Plantar hyperkeratosis (HP:0007556)2.69854564
64Abnormal delayed hypersensitivity skin test (HP:0002963)2.69795218
65IgG deficiency (HP:0004315)2.69520896
66Ketoacidosis (HP:0001993)2.67946009
67Acute encephalopathy (HP:0006846)2.67668207
68Gangrene (HP:0100758)2.66635751
69Hypotrichosis (HP:0001006)2.63635703
70Acute necrotizing encephalopathy (HP:0006965)2.60144646
71Molar tooth sign on MRI (HP:0002419)2.58753323
72Abnormality of midbrain morphology (HP:0002418)2.58753323
73Focal seizures (HP:0007359)2.58610008
74Pancreatic cysts (HP:0001737)2.55623426
75EMG: myopathic abnormalities (HP:0003458)2.55128861
76Abolished electroretinogram (ERG) (HP:0000550)2.55015849
77Abnormal mitochondria in muscle tissue (HP:0008316)2.55000335
78Hematochezia (HP:0002573)2.53037042
79True hermaphroditism (HP:0010459)2.52989974
80Abnormal EKG (HP:0003115)2.51439720
81Hypoplastic left heart (HP:0004383)2.50365540
82Abnormality of nail color (HP:0100643)2.48354346
83Hyperammonemia (HP:0001987)2.48299459
84Visual hallucinations (HP:0002367)2.47831405
85Palmoplantar keratoderma (HP:0000982)2.46166670
86Pustule (HP:0200039)2.45924263
87Abnormality of the nasal mucosa (HP:0000433)2.45488012
88Double outlet right ventricle (HP:0001719)2.41575382
89Congenital malformation of the right heart (HP:0011723)2.41575382
90Hepatic necrosis (HP:0002605)2.40949409
91Cerebral edema (HP:0002181)2.40895027
92Stomatitis (HP:0010280)2.40008171
93Sudden cardiac death (HP:0001645)2.39727503
94Respiratory distress (HP:0002098)2.39188253
95Muscle stiffness (HP:0003552)2.38393574
96Global brain atrophy (HP:0002283)2.37209764
97Ketosis (HP:0001946)2.35877337
98Thyroiditis (HP:0100646)2.34743649
99Increased neuronal autofluorescent lipopigment (HP:0002074)2.33683177
100Progressive macrocephaly (HP:0004481)2.33336658
101Pheochromocytoma (HP:0002666)2.33082005
102Cavernous hemangioma (HP:0001048)2.32310762
103Stomach cancer (HP:0012126)2.28005370
104Broad metatarsal (HP:0001783)2.26504527
105Spontaneous hematomas (HP:0007420)2.25451078
106Pancreatic fibrosis (HP:0100732)2.24907200
107Corneal erosion (HP:0200020)2.23540874
108Visceral angiomatosis (HP:0100761)2.23244685
109Panhypogammaglobulinemia (HP:0003139)2.22496901
110Tachypnea (HP:0002789)2.22106235
111Abnormality of fatty-acid metabolism (HP:0004359)2.21056229
112Split foot (HP:0001839)2.20851366
113Severe combined immunodeficiency (HP:0004430)2.19683587
114Agammaglobulinemia (HP:0004432)2.16374412
115Xanthomatosis (HP:0000991)2.16229990
116Renal cortical cysts (HP:0000803)2.15849362
117Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.15361886
118Hypergammaglobulinemia (HP:0010702)2.14764745
119Atonic seizures (HP:0010819)2.11777225
120Furrowed tongue (HP:0000221)2.10642561
121Distal lower limb muscle weakness (HP:0009053)2.10592840
122Hypothermia (HP:0002045)2.10592268
123Abnormality of eosinophils (HP:0001879)2.10282062
124Oral leukoplakia (HP:0002745)2.09405728
125Abnormality of the prostate (HP:0008775)2.09184521
126Alveolar cell carcinoma (HP:0006519)2.08680122
127Mitochondrial inheritance (HP:0001427)2.08639930
128Hyperkalemia (HP:0002153)2.07619742
129Abnormality of dicarboxylic acid metabolism (HP:0010995)2.07489058
130Dicarboxylic aciduria (HP:0003215)2.07489058
131Hyperlipoproteinemia (HP:0010980)2.07467508
132Action tremor (HP:0002345)2.06220768
133Chronic diarrhea (HP:0002028)2.05324425
134Chronic bronchitis (HP:0004469)2.03751423
135Increased connective tissue (HP:0009025)2.03635044
136Bile duct proliferation (HP:0001408)2.03197544
137Abnormal biliary tract physiology (HP:0012439)2.03197544
138Neuroendocrine neoplasm (HP:0100634)2.01710425
139Respiratory failure (HP:0002878)2.01454434
140Attenuation of retinal blood vessels (HP:0007843)2.01440534
141Hyperglycinuria (HP:0003108)2.00074110
142Increased muscle lipid content (HP:0009058)1.99422351
143Abnormality of the renal cortex (HP:0011035)1.98470598
144Esophageal varix (HP:0002040)1.97987280
145Abnormality of aromatic amino acid family metabolism (HP:0004338)1.97563068
146Hemangiomatosis (HP:0007461)1.97270489
147Intrahepatic cholestasis (HP:0001406)1.96775288
148Thick nail (HP:0001805)1.96545445
149Abnormality of T cell physiology (HP:0011840)1.96020088
150Rhabdomyolysis (HP:0003201)1.95644513
151Progressive cerebellar ataxia (HP:0002073)1.95550432
152Hyperventilation (HP:0002883)1.95513399
153Hepatocellular necrosis (HP:0001404)1.95348983
154Metabolic acidosis (HP:0001942)1.94811189
155Epileptic encephalopathy (HP:0200134)1.94473682
156Abnormal rod and cone electroretinograms (HP:0008323)1.94110552
157Eosinophilia (HP:0001880)1.93818412
158Neonatal death (HP:0003811)1.93297502
159Foot dorsiflexor weakness (HP:0009027)1.92782265
160Potter facies (HP:0002009)1.92737517
161Facial shape deformation (HP:0011334)1.92737517
162Decreased circulating renin level (HP:0003351)1.92373510
163Gaze-evoked nystagmus (HP:0000640)1.91595668
164Difficulty running (HP:0009046)1.90874493
165Dysdiadochokinesis (HP:0002075)1.90489202
166Recurrent cutaneous fungal infections (HP:0011370)1.89889843
167Chronic mucocutaneous candidiasis (HP:0002728)1.89889843
168Abnormality of the foot musculature (HP:0001436)1.89031632
169Myokymia (HP:0002411)1.88075234
170Abnormality of glycine metabolism (HP:0010895)1.86933568
171Abnormality of serine family amino acid metabolism (HP:0010894)1.86933568
172Abnormality of the renal collecting system (HP:0004742)1.86776409
173Hamartoma of the eye (HP:0010568)1.86438783
174Dialeptic seizures (HP:0011146)1.86378488
175Recurrent bronchitis (HP:0002837)1.85799883
176Megalencephaly (HP:0001355)1.85530314
177Encephalitis (HP:0002383)1.85283556
178Generalized tonic-clonic seizures (HP:0002069)1.84502180
179Absent rod-and cone-mediated responses on ERG (HP:0007688)1.84370957
180Ragged-red muscle fibers (HP:0003200)1.82049252
181Increased cerebral lipofuscin (HP:0011813)1.81604696
182Complement deficiency (HP:0004431)1.81414541
183Medial flaring of the eyebrow (HP:0010747)1.79820901
184Left ventricular hypertrophy (HP:0001712)1.79568139
185Hyperglycinemia (HP:0002154)1.76899411
186Fragile nails (HP:0001808)1.75589235
187Onycholysis (HP:0001806)1.74965546
188Recurrent skin infections (HP:0001581)1.72263915
189Nephronophthisis (HP:0000090)1.72162059
190Neoplasm of the tracheobronchial system (HP:0100552)1.71625551
191Absence seizures (HP:0002121)1.71237154
192Hypokalemic alkalosis (HP:0001949)1.70175074
193Truncal ataxia (HP:0002078)1.70081288
194Increased corneal curvature (HP:0100692)1.70020750
195Keratoconus (HP:0000563)1.70020750
196Impaired smooth pursuit (HP:0007772)1.69869749
197Chronic otitis media (HP:0000389)1.68807123

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.25548599
2TIE14.13663040
3LMTK24.10834901
4FRK3.32990721
5MYLK3.26865040
6TAOK33.21144497
7TTN2.89236977
8TRIB32.81495136
9STK242.59308071
10PHKG12.50869103
11PHKG22.50869103
12PKN22.22922029
13ADRBK22.21935423
14FES2.02974322
15EPHB12.02346382
16CASK1.98006107
17MAP4K21.88408853
18MAP4K11.81394064
19TGFBR21.81219796
20EPHB21.75703647
21RIPK11.72929354
22BMPR21.72468815
23DMPK1.71472015
24MAPK131.66278997
25MAP3K21.61813440
26GRK71.56321695
27BMPR1B1.56151269
28PRKD11.48831315
29FGFR41.48143764
30NUAK11.46673607
31OBSCN1.45004346
32PDK41.44043203
33PDK31.44043203
34LRRK21.42596929
35PIK3CA1.42400875
36EPHA41.41810368
37TNK21.39674964
38ILK1.37085458
39BCKDK1.32970701
40SYK1.28364186
41WNK41.27542996
42FER1.26119177
43PINK11.24574145
44GRK51.20210363
45MAP3K131.20138938
46KIT1.19559362
47STK391.19388019
48ERN11.19386595
49KSR21.18995231
50LIMK11.14836852
51PTK61.07320899
52PAK31.06082624
53PDK21.05193854
54MST41.03166475
55MAPKAPK31.03066972
56MARK11.03003210
57NTRK21.02513050
58MUSK1.01131605
59IKBKB1.00693694
60MAP3K30.98190878
61CSNK1G30.97057451
62CAMKK20.96653513
63JAK10.95202264
64CDC42BPA0.94695467
65WNK10.93084580
66CSNK1G20.92856987
67FGFR20.92672543
68DAPK10.91626263
69ROCK10.91075209
70CSNK1A1L0.90625053
71PAK60.89424494
72LCK0.89112073
73RET0.88476526
74TEC0.87890587
75SCYL20.85498952
76EPHA30.85248158
77PRKCH0.84552979
78DAPK30.84020215
79MAP3K10.83735127
80DAPK20.83283600
81KDR0.82735059
82NEK90.81606394
83PDPK10.81287954
84TESK20.81014652
85IKBKE0.80803168
86STK380.80117575
87PLK20.78661078
88SIK10.78323404
89MAPK120.77041393
90PDGFRA0.74924325
91PIK3CG0.74835856
92CSNK1G10.74332555
93MAP3K40.73652454
94PRKG20.73222031
95MAP3K70.72872169
96MST1R0.72268901
97ROCK20.69994276
98TGFBR10.69969357
99WNK30.69543598
100CCNB10.67653840
101GRK10.66661893
102OXSR10.65186689
103MAP2K30.65044713
104CAMK2D0.65001029
105PRKCQ0.64445295
106PRKCE0.63296670
107MAP3K120.62856832
108FGFR30.62798825
109CSK0.62196206
110DYRK1A0.61508127
111INSRR0.61285691
112MAP3K140.60931328
113PKN10.60563850
114LYN0.60459326
115JAK20.60071340
116MAP2K40.59275707
117IGF1R0.57203786
118TESK10.57057306
119PRKCA0.56165445
120CAMKK10.56087770
121PRKCG0.55964878
122MAP2K60.55609129
123MINK10.54042203
124FGFR10.54032741
125CAMK2G0.53659894
126FYN0.53306958
127ITK0.53288861
128ACVR1B0.53038811
129TRPM70.52918947
130PRKD30.52155670
131STK38L0.51541092
132MAPK70.51229255
133PDK10.51152009
134MAP3K110.50770860
135PRKACG0.49339384
136MAPKAPK50.49122524
137SGK2230.47934999
138SGK4940.47934999
139PRKAA20.47199232
140BTK0.46367890
141CAMK2A0.46284708
142CSNK1A10.45518151
143SGK10.45370839
144PRKACA0.45266299
145PTK2B0.45144847
146CAMK40.44817579
147TBK10.44493505
148CDK50.43441919
149TYK20.43386689
150JAK30.43062314
151SGK20.42408228
152NTRK10.42084222
153PDGFRB0.41458646
154MAP2K20.40352481
155NTRK30.39531619
156STK100.39462540
157NEK10.38455661
158EGFR0.37495283
159ADRBK10.37384885
160GSK3A0.36665559

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.20014523
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.18321049
3Fatty acid degradation_Homo sapiens_hsa000712.92301329
4Cardiac muscle contraction_Homo sapiens_hsa042602.91253409
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.87444518
6Linoleic acid metabolism_Homo sapiens_hsa005912.80659781
7Graft-versus-host disease_Homo sapiens_hsa053322.79796989
8Nitrogen metabolism_Homo sapiens_hsa009102.77374440
9Oxidative phosphorylation_Homo sapiens_hsa001902.76933373
10Parkinsons disease_Homo sapiens_hsa050122.52969015
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.51107202
12Autoimmune thyroid disease_Homo sapiens_hsa053202.32748663
13Phototransduction_Homo sapiens_hsa047442.32675586
14Propanoate metabolism_Homo sapiens_hsa006402.28324413
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.26564550
16Antigen processing and presentation_Homo sapiens_hsa046122.21225893
17Type I diabetes mellitus_Homo sapiens_hsa049402.15715576
18Alzheimers disease_Homo sapiens_hsa050102.13802414
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.10669946
20Allograft rejection_Homo sapiens_hsa053302.08769493
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.06543515
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.99000722
23Fatty acid metabolism_Homo sapiens_hsa012121.98578947
24Nicotine addiction_Homo sapiens_hsa050331.96834306
25Dilated cardiomyopathy_Homo sapiens_hsa054141.92484155
26Ether lipid metabolism_Homo sapiens_hsa005651.85047512
27Fatty acid elongation_Homo sapiens_hsa000621.84778952
28Tryptophan metabolism_Homo sapiens_hsa003801.82631723
29Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.80207373
30Arginine biosynthesis_Homo sapiens_hsa002201.66625300
31Primary bile acid biosynthesis_Homo sapiens_hsa001201.59969290
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.59182665
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.56779824
34GABAergic synapse_Homo sapiens_hsa047271.56605178
35Pyruvate metabolism_Homo sapiens_hsa006201.55480818
36Glutamatergic synapse_Homo sapiens_hsa047241.54864806
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.53793547
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.49917818
39Butanoate metabolism_Homo sapiens_hsa006501.49761967
40Morphine addiction_Homo sapiens_hsa050321.49404313
41PPAR signaling pathway_Homo sapiens_hsa033201.48831409
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.47891667
43Huntingtons disease_Homo sapiens_hsa050161.46153358
44Rheumatoid arthritis_Homo sapiens_hsa053231.39029327
45Arachidonic acid metabolism_Homo sapiens_hsa005901.36424015
46Amphetamine addiction_Homo sapiens_hsa050311.35789982
47Olfactory transduction_Homo sapiens_hsa047401.35606651
48Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.33689043
49Carbon metabolism_Homo sapiens_hsa012001.31758564
50Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.30895154
51Serotonergic synapse_Homo sapiens_hsa047261.28455527
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.24944565
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.22822000
54Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.18821136
55Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.15313385
56Peroxisome_Homo sapiens_hsa041461.14954448
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.14432535
58T cell receptor signaling pathway_Homo sapiens_hsa046601.12961198
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.11988871
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.11421388
61beta-Alanine metabolism_Homo sapiens_hsa004101.10849378
62Bile secretion_Homo sapiens_hsa049761.10324179
63Long-term depression_Homo sapiens_hsa047301.10003815
64Hematopoietic cell lineage_Homo sapiens_hsa046401.09926660
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.08851900
66Collecting duct acid secretion_Homo sapiens_hsa049661.07014713
67Complement and coagulation cascades_Homo sapiens_hsa046101.06525013
68Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.05798686
69Asthma_Homo sapiens_hsa053101.04968030
70Intestinal immune network for IgA production_Homo sapiens_hsa046721.02044171
71Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.01439108
72Dopaminergic synapse_Homo sapiens_hsa047281.00594374
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.98119838
74Regulation of autophagy_Homo sapiens_hsa041400.97531996
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.96177286
76Histidine metabolism_Homo sapiens_hsa003400.85384219
77Synaptic vesicle cycle_Homo sapiens_hsa047210.83945048
78Long-term potentiation_Homo sapiens_hsa047200.83564309
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81607153
80Circadian rhythm_Homo sapiens_hsa047100.81147291
81Caffeine metabolism_Homo sapiens_hsa002320.81034621
82Chemical carcinogenesis_Homo sapiens_hsa052040.79943905
83Phenylalanine metabolism_Homo sapiens_hsa003600.78754057
84Viral myocarditis_Homo sapiens_hsa054160.76206003
85Ovarian steroidogenesis_Homo sapiens_hsa049130.75889643
86Starch and sucrose metabolism_Homo sapiens_hsa005000.74020199
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.71643169
88Dorso-ventral axis formation_Homo sapiens_hsa043200.71091641
89Sulfur metabolism_Homo sapiens_hsa009200.71008118
90Insulin resistance_Homo sapiens_hsa049310.70392992
91Gastric acid secretion_Homo sapiens_hsa049710.70389110
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.66649416
93Renin secretion_Homo sapiens_hsa049240.66589012
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66383170
95Leukocyte transendothelial migration_Homo sapiens_hsa046700.64707324
96Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.62300726
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.62172320
98Fatty acid biosynthesis_Homo sapiens_hsa000610.62164131
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61921789
100Taste transduction_Homo sapiens_hsa047420.60376581
101Tight junction_Homo sapiens_hsa045300.60275079
102Vascular smooth muscle contraction_Homo sapiens_hsa042700.59866726
103Steroid hormone biosynthesis_Homo sapiens_hsa001400.59823741
104ABC transporters_Homo sapiens_hsa020100.59417131
105Retinol metabolism_Homo sapiens_hsa008300.59328465
106Chemokine signaling pathway_Homo sapiens_hsa040620.58308772
107Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58154479
108Salivary secretion_Homo sapiens_hsa049700.55274131
109Staphylococcus aureus infection_Homo sapiens_hsa051500.55199486
110ECM-receptor interaction_Homo sapiens_hsa045120.54278010
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52180538
112NF-kappa B signaling pathway_Homo sapiens_hsa040640.51867467
113Focal adhesion_Homo sapiens_hsa045100.50244538
114Arginine and proline metabolism_Homo sapiens_hsa003300.50133159
115Protein export_Homo sapiens_hsa030600.50026790
116Ras signaling pathway_Homo sapiens_hsa040140.49856191
117RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.49314071
118Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48981630
119Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.47201497
120Fat digestion and absorption_Homo sapiens_hsa049750.46410991
121Glucagon signaling pathway_Homo sapiens_hsa049220.45132770
122Tyrosine metabolism_Homo sapiens_hsa003500.45102068
123Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.43148927
124VEGF signaling pathway_Homo sapiens_hsa043700.43085889
125Amoebiasis_Homo sapiens_hsa051460.42769110
126Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.41026150
127Cocaine addiction_Homo sapiens_hsa050300.40999083
128Maturity onset diabetes of the young_Homo sapiens_hsa049500.39329411
129Insulin signaling pathway_Homo sapiens_hsa049100.39322379
130Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39097536
131Calcium signaling pathway_Homo sapiens_hsa040200.39020402
132AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.37268607
133Prion diseases_Homo sapiens_hsa050200.36826066
134Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36323188
135Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35595833
136Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35260705
137Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34754255
138Insulin secretion_Homo sapiens_hsa049110.34625901
139Pancreatic secretion_Homo sapiens_hsa049720.33659683
140Biosynthesis of amino acids_Homo sapiens_hsa012300.33143301
141cAMP signaling pathway_Homo sapiens_hsa040240.32532928
142Mineral absorption_Homo sapiens_hsa049780.32357070
143Adherens junction_Homo sapiens_hsa045200.32291138
144Aldosterone synthesis and secretion_Homo sapiens_hsa049250.30270419
145Rap1 signaling pathway_Homo sapiens_hsa040150.30168832
146Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.28971447
147Oxytocin signaling pathway_Homo sapiens_hsa049210.28964075
148Type II diabetes mellitus_Homo sapiens_hsa049300.28308589
149Platelet activation_Homo sapiens_hsa046110.27741195
150Glycerolipid metabolism_Homo sapiens_hsa005610.26116748
151Renal cell carcinoma_Homo sapiens_hsa052110.26061241
152Pertussis_Homo sapiens_hsa051330.25725018
153Circadian entrainment_Homo sapiens_hsa047130.25049808
154GnRH signaling pathway_Homo sapiens_hsa049120.24503129
155Glutathione metabolism_Homo sapiens_hsa004800.23809879
156Cholinergic synapse_Homo sapiens_hsa047250.23271231

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