HOOK3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)4.37224716
2behavioral response to nicotine (GO:0035095)3.85071485
3presynaptic membrane organization (GO:0097090)3.68456846
4postsynaptic membrane organization (GO:0001941)3.48506396
5regulation of hippo signaling (GO:0035330)3.13322403
6membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.09511270
7neural tube formation (GO:0001841)2.95945503
8positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.93016271
9kidney morphogenesis (GO:0060993)2.92516025
10import into cell (GO:0098657)2.92211688
11tryptophan catabolic process (GO:0006569)2.91227554
12indole-containing compound catabolic process (GO:0042436)2.91227554
13indolalkylamine catabolic process (GO:0046218)2.91227554
14epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.90813581
15somite development (GO:0061053)2.83064890
16negative regulation of cytosolic calcium ion concentration (GO:0051481)2.83009976
17establishment of protein localization to Golgi (GO:0072600)2.81182149
18regulation of pigment cell differentiation (GO:0050932)2.79974857
19negative regulation of systemic arterial blood pressure (GO:0003085)2.78965395
20positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.78755221
21neuronal action potential (GO:0019228)2.78502293
22membrane depolarization during action potential (GO:0086010)2.73397616
23lymphangiogenesis (GO:0001946)2.72595078
24regulation of mesoderm development (GO:2000380)2.69026896
25omega-hydroxylase P450 pathway (GO:0097267)2.68000114
26negative regulation of Rho protein signal transduction (GO:0035024)2.67919326
27L-fucose catabolic process (GO:0042355)2.66810965
28fucose catabolic process (GO:0019317)2.66810965
29L-fucose metabolic process (GO:0042354)2.66810965
30serotonin metabolic process (GO:0042428)2.63873262
31cAMP catabolic process (GO:0006198)2.62330152
32membrane assembly (GO:0071709)2.61248824
33embryonic retina morphogenesis in camera-type eye (GO:0060059)2.61156076
34cyclic nucleotide catabolic process (GO:0009214)2.58142976
35short-term memory (GO:0007614)2.55967356
36neuron cell-cell adhesion (GO:0007158)2.55944334
37artery development (GO:0060840)2.54008389
38photoreceptor cell differentiation (GO:0046530)2.53941850
39eye photoreceptor cell differentiation (GO:0001754)2.53941850
40reflex (GO:0060004)2.53894800
41positive regulation of protein kinase C signaling (GO:0090037)2.51756141
42primary amino compound metabolic process (GO:1901160)2.50554753
43sulfation (GO:0051923)2.47682907
44regulation of non-canonical Wnt signaling pathway (GO:2000050)2.47499114
45central nervous system projection neuron axonogenesis (GO:0021952)2.46096124
46limb bud formation (GO:0060174)2.44191804
47prostate gland growth (GO:0060736)2.42844268
48negative regulation of mast cell activation (GO:0033004)2.41980513
49kynurenine metabolic process (GO:0070189)2.41384562
50indolalkylamine metabolic process (GO:0006586)2.41334485
51dendrite morphogenesis (GO:0048813)2.41193447
52regulation of axon extension involved in axon guidance (GO:0048841)2.40769357
53dermatan sulfate biosynthetic process (GO:0030208)2.40164218
54spinal cord motor neuron differentiation (GO:0021522)2.39159757
55lipid translocation (GO:0034204)2.38627869
56phospholipid translocation (GO:0045332)2.38627869
57neurotransmitter-gated ion channel clustering (GO:0072578)2.37674333
58central nervous system neuron axonogenesis (GO:0021955)2.37523930
59negative regulation of neurotransmitter secretion (GO:0046929)2.36206564
60cranial nerve structural organization (GO:0021604)2.35753573
61regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.35614413
62neuron maturation (GO:0042551)2.33179930
63renal tubule morphogenesis (GO:0061333)2.33026824
64substrate-dependent cell migration (GO:0006929)2.32985483
65regulation of axon guidance (GO:1902667)2.32208758
66histone H3-K4 trimethylation (GO:0080182)2.30290518
67regulation of establishment of cell polarity (GO:2000114)2.30145681
68* interkinetic nuclear migration (GO:0022027)2.29994775
69tryptophan metabolic process (GO:0006568)2.29597830
70embryonic camera-type eye morphogenesis (GO:0048596)2.29409661
71pyrimidine nucleobase catabolic process (GO:0006208)2.28154295
72nephron tubule morphogenesis (GO:0072078)2.27648868
73nephron epithelium morphogenesis (GO:0072088)2.27648868
74retinal cone cell development (GO:0046549)2.27340207
75protein targeting to Golgi (GO:0000042)2.27256406
76retina layer formation (GO:0010842)2.27076854
77G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.25102598
78pericardium development (GO:0060039)2.25065248
79negative regulation of protein localization to cell surface (GO:2000009)2.25037529
80behavioral response to ethanol (GO:0048149)2.24672824
81eye photoreceptor cell development (GO:0042462)2.24202588
82detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.22969600
83retrograde transport, vesicle recycling within Golgi (GO:0000301)2.22939949
84photoreceptor cell maintenance (GO:0045494)2.22865013
85Golgi to endosome transport (GO:0006895)2.22166212
86indole-containing compound metabolic process (GO:0042430)2.21767126
87positive regulation of cardiac muscle cell differentiation (GO:2000727)2.20806229
88protein K11-linked deubiquitination (GO:0035871)2.20719629
89positive regulation of smooth muscle cell migration (GO:0014911)2.19898709
90kidney mesenchyme development (GO:0072074)2.19426816
91cell proliferation in forebrain (GO:0021846)2.18409321
92mesenchymal-epithelial cell signaling (GO:0060638)2.17987703
93regulation of sarcomere organization (GO:0060297)2.17875397
94macroautophagy (GO:0016236)2.17817830
95cerebral cortex radially oriented cell migration (GO:0021799)2.17537757
96glomerulus development (GO:0032835)2.17522059
97regulation of establishment or maintenance of cell polarity (GO:0032878)2.16662572
98L-amino acid import (GO:0043092)2.16473148
99negative regulation of keratinocyte proliferation (GO:0010839)2.16164253
100regulation of rhodopsin mediated signaling pathway (GO:0022400)2.15744712
101ionotropic glutamate receptor signaling pathway (GO:0035235)2.15567121
102endoderm formation (GO:0001706)2.15422417
103regulation of gene silencing by miRNA (GO:0060964)2.14776403
104regulation of gene silencing by RNA (GO:0060966)2.14776403
105regulation of posttranscriptional gene silencing (GO:0060147)2.14776403
106regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.14615580
107gamma-aminobutyric acid transport (GO:0015812)2.14098859
108cellular ketone body metabolic process (GO:0046950)2.13749398
109positive regulation of fatty acid oxidation (GO:0046321)2.13536635
110anatomical structure arrangement (GO:0048532)2.13449804
111photoreceptor cell development (GO:0042461)2.13375917
112negative regulation of astrocyte differentiation (GO:0048712)2.13361995
113monoubiquitinated protein deubiquitination (GO:0035520)2.13224881
114* nucleus localization (GO:0051647)2.13086598
115regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.12938580
116ovulation cycle (GO:0042698)2.12921542
117cilium or flagellum-dependent cell motility (GO:0001539)2.12848312
118negative regulation of glucose import (GO:0046325)2.12308415
119sequestering of extracellular ligand from receptor (GO:0035581)2.12191093
120detection of light stimulus involved in sensory perception (GO:0050962)2.12166037
121detection of light stimulus involved in visual perception (GO:0050908)2.12166037
122action potential (GO:0001508)2.12011563
123positive regulation of cellular amide metabolic process (GO:0034250)2.11532171
124musculoskeletal movement (GO:0050881)2.10787925
125multicellular organismal movement (GO:0050879)2.10787925
126ganglion development (GO:0061548)2.10198759
127rhodopsin mediated signaling pathway (GO:0016056)2.09743799
128atrial cardiac muscle cell action potential (GO:0086014)2.09629310
129limb development (GO:0060173)2.08305235
130appendage development (GO:0048736)2.08305235
131positive regulation of dendritic spine development (GO:0060999)2.06717589
132negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.06070365
133negative regulation of translation, ncRNA-mediated (GO:0040033)2.06070365
134regulation of translation, ncRNA-mediated (GO:0045974)2.06070365
135cell differentiation involved in kidney development (GO:0061005)2.05722886
136mesenchymal cell differentiation (GO:0048762)2.05708980
137startle response (GO:0001964)2.05481418
138regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.05150197
139positive regulation of synapse assembly (GO:0051965)2.05093987
140regulation of synapse assembly (GO:0051963)2.04682300
141dendritic spine morphogenesis (GO:0060997)1.99984831
142retina vasculature morphogenesis in camera-type eye (GO:0061299)1.98864159
143negative regulation of synaptic transmission, GABAergic (GO:0032229)1.98179206
144facial nerve structural organization (GO:0021612)1.96561187
145protein localization to synapse (GO:0035418)1.94945749
146protein heterotetramerization (GO:0051290)1.94700828
147amino acid import (GO:0043090)1.94418413
148cerebellar Purkinje cell differentiation (GO:0021702)1.94383038
149chondrocyte development (GO:0002063)1.93969200
150regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 1.92420405
151regulation of phospholipase A2 activity (GO:0032429)1.92019054
152pigmentation (GO:0043473)1.91575571
153cranial nerve morphogenesis (GO:0021602)1.90776265
154myelination in peripheral nervous system (GO:0022011)1.89704973
155peripheral nervous system axon ensheathment (GO:0032292)1.89704973
156lymph vessel development (GO:0001945)1.89673162
157cerebral cortex cell migration (GO:0021795)1.89510352
158insulin-like growth factor receptor signaling pathway (GO:0048009)1.88489417
159phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)1.88201405
160negative regulation of neurotransmitter transport (GO:0051589)1.88139822
161mesenchymal cell differentiation involved in kidney development (GO:0072161)1.87705360
162mesenchymal cell differentiation involved in renal system development (GO:2001012)1.87705360
163regulation of dendritic spine development (GO:0060998)1.85367705
164glutamate receptor signaling pathway (GO:0007215)1.84992164
165cellular response to cholesterol (GO:0071397)1.84841334
166cytoplasmic mRNA processing body assembly (GO:0033962)1.84732408
167negative chemotaxis (GO:0050919)1.84321520
168cell morphogenesis involved in neuron differentiation (GO:0048667)1.83988006
169cellular response to sterol (GO:0036315)1.83504018
170negative regulation of axon extension involved in axon guidance (GO:0048843)1.83488816
171regulation of respiratory system process (GO:0044065)1.83398957
172neuron remodeling (GO:0016322)1.83109255
173regulation of excitatory postsynaptic membrane potential (GO:0060079)1.82709011
174peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)1.82688580

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.44279872
2EZH2_22144423_ChIP-Seq_EOC_Human2.99484110
3CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.34184197
4SMAD_19615063_ChIP-ChIP_OVARY_Human2.26778621
5CDX2_19796622_ChIP-Seq_MESCs_Mouse2.14242447
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.13106848
7ZNF274_21170338_ChIP-Seq_K562_Hela2.09062992
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.06057924
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.05068364
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.03430193
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.02824134
12VDR_22108803_ChIP-Seq_LS180_Human2.01237818
13PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.00227581
14AR_21572438_ChIP-Seq_LNCaP_Human1.99048179
15EED_16625203_ChIP-ChIP_MESCs_Mouse1.97901666
16POU3F2_20337985_ChIP-ChIP_501MEL_Human1.96755401
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.94106007
18PIAS1_25552417_ChIP-Seq_VCAP_Human1.93397838
19SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.92340431
20EZH2_27304074_Chip-Seq_ESCs_Mouse1.83060768
21EZH2_18974828_ChIP-Seq_MESCs_Mouse1.83001030
22RNF2_18974828_ChIP-Seq_MESCs_Mouse1.83001030
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.81561733
24TAF15_26573619_Chip-Seq_HEK293_Human1.75001117
25* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.72430336
26RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71927636
27ZNF217_24962896_ChIP-Seq_MCF-7_Human1.71821964
28* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.69887872
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.69737021
30FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.67355039
31P300_19829295_ChIP-Seq_ESCs_Human1.65177164
32RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.65130114
33SALL1_21062744_ChIP-ChIP_HESCs_Human1.65010512
34IGF1R_20145208_ChIP-Seq_DFB_Human1.60901984
35* SMAD4_21799915_ChIP-Seq_A2780_Human1.60050370
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58655768
37JARID2_20075857_ChIP-Seq_MESCs_Mouse1.58357180
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.57905184
39FLI1_27457419_Chip-Seq_LIVER_Mouse1.57380759
40SUZ12_27294783_Chip-Seq_NPCs_Mouse1.54463588
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52685155
42UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49482721
43RNF2_27304074_Chip-Seq_ESCs_Mouse1.49100856
44MTF2_20144788_ChIP-Seq_MESCs_Mouse1.48694123
45TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.46662237
46PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.46307370
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.45643148
48ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.45451352
49NANOG_18555785_Chip-Seq_ESCs_Mouse1.45375209
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43474232
51* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42958137
52DROSHA_22980978_ChIP-Seq_HELA_Human1.42103180
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.41239818
54TP53_16413492_ChIP-PET_HCT116_Human1.40492597
55TP53_18474530_ChIP-ChIP_U2OS_Human1.39477155
56PCGF2_27294783_Chip-Seq_NPCs_Mouse1.38929951
57EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.38695560
58SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.38126427
59ER_23166858_ChIP-Seq_MCF-7_Human1.38009550
60E2F1_18555785_Chip-Seq_ESCs_Mouse1.37182492
61NFE2_27457419_Chip-Seq_LIVER_Mouse1.36928173
62* STAT3_23295773_ChIP-Seq_U87_Human1.36717556
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.36238400
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35403395
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34605254
66EZH2_27294783_Chip-Seq_ESCs_Mouse1.31872222
67TRIM28_21343339_ChIP-Seq_HEK293_Human1.31109557
68ARNT_22903824_ChIP-Seq_MCF-7_Human1.30280476
69TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.30028782
70WT1_19549856_ChIP-ChIP_CCG9911_Human1.29675539
71AHR_22903824_ChIP-Seq_MCF-7_Human1.29569776
72HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.29173928
73MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27656628
74NRF2_20460467_ChIP-Seq_MEFs_Mouse1.27644714
75NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.27644714
76P53_22387025_ChIP-Seq_ESCs_Mouse1.27432778
77BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.27290982
78RNF2_27304074_Chip-Seq_NSC_Mouse1.26766425
79TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26470104
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26387592
81SUZ12_27294783_Chip-Seq_ESCs_Mouse1.25306879
82TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24669211
83VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.24393862
84NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23799516
85AR_25329375_ChIP-Seq_VCAP_Human1.23498053
86SUZ12_18555785_Chip-Seq_ESCs_Mouse1.23382834
87CBP_20019798_ChIP-Seq_JUKART_Human1.22726770
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22726770
89CMYC_18555785_Chip-Seq_ESCs_Mouse1.22424244
90SOX2_21211035_ChIP-Seq_LN229_Gbm1.20956856
91* TCF4_23295773_ChIP-Seq_U87_Human1.20505344
92BMI1_23680149_ChIP-Seq_NPCS_Mouse1.19982031
93PRDM14_20953172_ChIP-Seq_ESCs_Human1.19308069
94KDM2B_26808549_Chip-Seq_REH_Human1.18651545
95FLI1_21867929_ChIP-Seq_TH2_Mouse1.18108273
96REST_21632747_ChIP-Seq_MESCs_Mouse1.17858949
97CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.16842227
98FUS_26573619_Chip-Seq_HEK293_Human1.15960072
99EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.14973427
100TCF4_22108803_ChIP-Seq_LS180_Human1.14852169
101RUNX2_22187159_ChIP-Seq_PCA_Human1.14245144
102TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13889473
103POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13889473
104SMAD4_21741376_ChIP-Seq_EPCs_Human1.13697992
105P300_18555785_Chip-Seq_ESCs_Mouse1.12092292
106ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.10872648
107FOXM1_26456572_ChIP-Seq_MCF-7_Human1.10310346
108TCF4_18268006_ChIP-ChIP_LS174T_Human1.09614642
109EP300_21415370_ChIP-Seq_HL-1_Mouse1.09026370
110BCAT_22108803_ChIP-Seq_LS180_Human1.08265280
111NMYC_18555785_Chip-Seq_ESCs_Mouse1.08204301
112RXR_22108803_ChIP-Seq_LS180_Human1.07715017
113BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07176592
114SMAD3_21741376_ChIP-Seq_HESCs_Human1.07076425
115SOX2_18555785_Chip-Seq_ESCs_Mouse1.06209235
116STAT3_18555785_Chip-Seq_ESCs_Mouse1.06112883
117PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06109382
118CJUN_26792858_Chip-Seq_BT549_Human1.06040339
119LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05490590
120EWS_26573619_Chip-Seq_HEK293_Human1.05474776
121CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04637426
122OCT4_18555785_Chip-Seq_ESCs_Mouse1.04232806
123PU1_27457419_Chip-Seq_LIVER_Mouse1.02425514
124* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02414905
125RUNX1_27457419_Chip-Seq_LIVER_Mouse1.02101638

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.80691357
2MP0005409_darkened_coat_color3.65106543
3MP0001188_hyperpigmentation3.25232270
4MP0003136_yellow_coat_color3.10953845
5MP0003646_muscle_fatigue2.72885758
6MP0003880_abnormal_central_pattern2.57739696
7MP0005171_absent_coat_pigmentation2.52861694
8MP0005503_abnormal_tendon_morphology2.51936026
9MP0004381_abnormal_hair_follicle2.42067617
10MP0008438_abnormal_cutaneous_collagen2.37872812
11MP0010368_abnormal_lymphatic_system2.33345782
12MP0009780_abnormal_chondrocyte_physiolo2.19924422
13MP0005551_abnormal_eye_electrophysiolog2.14599510
14MP0004130_abnormal_muscle_cell2.12638068
15MP0003195_calcinosis2.10725634
16MP0001485_abnormal_pinna_reflex2.09834041
17MP0003950_abnormal_plasma_membrane2.09672919
18MP0003890_abnormal_embryonic-extraembry2.04773100
19MP0004142_abnormal_muscle_tone2.00859960
20MP0003011_delayed_dark_adaptation2.00512281
21MP0001299_abnormal_eye_distance/1.98549350
22MP0001879_abnormal_lymphatic_vessel1.94768704
23MP0002009_preneoplasia1.91870741
24MP0006292_abnormal_olfactory_placode1.80450484
25MP0009379_abnormal_foot_pigmentation1.76334922
26MP0004145_abnormal_muscle_electrophysio1.75571018
27MP0000566_synostosis1.73432626
28MP0003045_fibrosis1.73419102
29MP0009250_abnormal_appendicular_skeleto1.68764830
30MP0005275_abnormal_skin_tensile1.67481355
31MP0009384_cardiac_valve_regurgitation1.66742594
32MP0000427_abnormal_hair_cycle1.65257405
33MP0003878_abnormal_ear_physiology1.63044408
34MP0005377_hearing/vestibular/ear_phenot1.63044408
35MP0002102_abnormal_ear_morphology1.60795076
36MP0003283_abnormal_digestive_organ1.58129257
37MP0004272_abnormal_basement_membrane1.57436787
38MP0002638_abnormal_pupillary_reflex1.52950971
39MP0001486_abnormal_startle_reflex1.51182850
40MP0002272_abnormal_nervous_system1.49045310
41MP0001968_abnormal_touch/_nociception1.49010680
42MP0000778_abnormal_nervous_system1.45225051
43MP0005174_abnormal_tail_pigmentation1.44506789
44MP0000015_abnormal_ear_pigmentation1.41980306
45MP0005253_abnormal_eye_physiology1.40398439
46MP0002177_abnormal_outer_ear1.39709337
47MP0003868_abnormal_feces_composition1.36464154
48MP0002572_abnormal_emotion/affect_behav1.32770459
49MP0000631_abnormal_neuroendocrine_gland1.32315577
50MP0001501_abnormal_sleep_pattern1.32095891
51MP0001346_abnormal_lacrimal_gland1.31905372
52MP0004043_abnormal_pH_regulation1.30656466
53MP0001177_atelectasis1.30257159
54MP0002063_abnormal_learning/memory/cond1.28336088
55MP0003252_abnormal_bile_duct1.27679878
56MP0005167_abnormal_blood-brain_barrier1.27511581
57MP0003385_abnormal_body_wall1.27193166
58MP0004133_heterotaxia1.26447339
59MP0001986_abnormal_taste_sensitivity1.25761756
60MP0005257_abnormal_intraocular_pressure1.25241870
61MP0001324_abnormal_eye_pigmentation1.24087950
62MP0002734_abnormal_mechanical_nocicepti1.23599300
63MP0002928_abnormal_bile_duct1.23088965
64MP0010386_abnormal_urinary_bladder1.22897112
65MP0002108_abnormal_muscle_morphology1.21333873
66MP0008877_abnormal_DNA_methylation1.21132110
67MP0000383_abnormal_hair_follicle1.20136247
68MP0003632_abnormal_nervous_system1.20074557
69MP0001440_abnormal_grooming_behavior1.19501380
70MP0001661_extended_life_span1.17450156
71MP0004215_abnormal_myocardial_fiber1.14778422
72MP0001984_abnormal_olfaction1.13858267
73MP0005423_abnormal_somatic_nervous1.13766462
74MP0005646_abnormal_pituitary_gland1.13495706
75MP0004924_abnormal_behavior1.13212526
76MP0005386_behavior/neurological_phenoty1.13212526
77MP0004742_abnormal_vestibular_system1.11307489
78MP0000230_abnormal_systemic_arterial1.11136514
79MP0002938_white_spotting1.10169280
80MP0000026_abnormal_inner_ear1.10137282
81MP0000579_abnormal_nail_morphology1.08545616
82MP0002876_abnormal_thyroid_physiology1.08369660
83MP0009046_muscle_twitch1.08357279
84MP0002735_abnormal_chemical_nociception1.06465861
85MP0002249_abnormal_larynx_morphology1.05705744
86MP0006276_abnormal_autonomic_nervous1.05449705
87MP0003119_abnormal_digestive_system1.05006778
88MP0002733_abnormal_thermal_nociception1.03919941
89MP0002184_abnormal_innervation1.03441925
90MP0003633_abnormal_nervous_system1.02231538
91MP0001270_distended_abdomen1.01179006
92MP0005195_abnormal_posterior_eye1.00979831
93MP0002067_abnormal_sensory_capabilities1.00819822
94MP0005248_abnormal_Harderian_gland1.00096977
95MP0001970_abnormal_pain_threshold0.99983395
96MP0009745_abnormal_behavioral_response0.99830814
97MP0003828_pulmonary_edema0.99425096
98MP0000920_abnormal_myelination0.98431979
99MP0002168_other_aberrant_phenotype0.96383814
100MP0003724_increased_susceptibility_to0.94940806
101MP0000955_abnormal_spinal_cord0.94909045
102MP0005084_abnormal_gallbladder_morpholo0.93940005
103MP0004270_analgesia0.93481892
104MP0003937_abnormal_limbs/digits/tail_de0.93102783
105MP0003635_abnormal_synaptic_transmissio0.92849988
106MP0003091_abnormal_cell_migration0.92566314
107MP0000049_abnormal_middle_ear0.92336121
108MP0003631_nervous_system_phenotype0.91858032
109MP0008057_abnormal_DNA_replication0.91513097
110MP0001963_abnormal_hearing_physiology0.90879655
111MP0003941_abnormal_skin_development0.90406371
112MP0002736_abnormal_nociception_after0.90134184
113MP0006072_abnormal_retinal_apoptosis0.90025944
114MP0003879_abnormal_hair_cell0.88796727
115MP0002837_dystrophic_cardiac_calcinosis0.88645610
116MP0004085_abnormal_heartbeat0.88263927
117MP0003755_abnormal_palate_morphology0.87705512
118MP0005595_abnormal_vascular_smooth0.87619937
119MP0004134_abnormal_chest_morphology0.86115143
120MP0004885_abnormal_endolymph0.85824626
121MP0002557_abnormal_social/conspecific_i0.85810001
122MP0001958_emphysema0.85130945
123MP0002095_abnormal_skin_pigmentation0.84346202
124MP0002882_abnormal_neuron_morphology0.83464199
125MP0000767_abnormal_smooth_muscle0.82938780
126MP0003935_abnormal_craniofacial_develop0.82572616
127MP0005197_abnormal_uvea_morphology0.82069965
128MP0002233_abnormal_nose_morphology0.81783398
129MP0002282_abnormal_trachea_morphology0.80610669
130MP0000534_abnormal_ureter_morphology0.80545868
131MP0001502_abnormal_circadian_rhythm0.80271311
132MP0002998_abnormal_bone_remodeling0.79439716
133MP0005620_abnormal_muscle_contractility0.78648216
134MP0005391_vision/eye_phenotype0.78318891
135MP0010678_abnormal_skin_adnexa0.78046606
136MP0002109_abnormal_limb_morphology0.77805163
137MP0003690_abnormal_glial_cell0.77587988
138MP0000647_abnormal_sebaceous_gland0.77464659
139MP0000163_abnormal_cartilage_morphology0.76899601
140MP0002064_seizures0.75951575
141MP0005187_abnormal_penis_morphology0.75137615
142MP0002139_abnormal_hepatobiliary_system0.74603730
143MP0005645_abnormal_hypothalamus_physiol0.74269233
144MP0003787_abnormal_imprinting0.73382531
145MP0000613_abnormal_salivary_gland0.72651182
146MP0002133_abnormal_respiratory_system0.72307931
147MP0005388_respiratory_system_phenotype0.72307931
148MP0005670_abnormal_white_adipose0.72234546
149MP0005508_abnormal_skeleton_morphology0.71384626
150MP0004859_abnormal_synaptic_plasticity0.71018415
151MP0001340_abnormal_eyelid_morphology0.70772984
152MP0002752_abnormal_somatic_nervous0.70468570
153MP0005360_urolithiasis0.69472223

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.73530438
2Dyschromatopsia (HP:0007641)3.40133568
3Pancreatic fibrosis (HP:0100732)3.25430182
4Molar tooth sign on MRI (HP:0002419)3.16794763
5Abnormality of midbrain morphology (HP:0002418)3.16794763
6Congenital stationary night blindness (HP:0007642)3.16220649
7Abnormality of the renal cortex (HP:0011035)3.09110250
8Genetic anticipation (HP:0003743)3.08519923
9Decreased central vision (HP:0007663)3.06517398
10Nephronophthisis (HP:0000090)3.04007056
11True hermaphroditism (HP:0010459)3.03849142
12Abnormality of the renal medulla (HP:0100957)2.99385394
13Chorioretinal atrophy (HP:0000533)2.98086988
14Abnormality of the nasal septum (HP:0000419)2.94064009
15Progressive cerebellar ataxia (HP:0002073)2.90265465
16Chronic hepatic failure (HP:0100626)2.88386371
17Midline defect of the nose (HP:0004122)2.83556684
18Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.83395929
19Pigmentary retinal degeneration (HP:0001146)2.83297993
20Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.83161546
21Abnormality of the frontal sinuses (HP:0002687)2.82736057
22Keratoconus (HP:0000563)2.81723596
23Increased corneal curvature (HP:0100692)2.81723596
24Abnormality of incisor morphology (HP:0011063)2.75706295
25Tubular atrophy (HP:0000092)2.69594277
26Febrile seizures (HP:0002373)2.68024520
27Aplasia/Hypoplasia of the tibia (HP:0005772)2.66999347
28Submucous cleft hard palate (HP:0000176)2.66164049
29Short hallux (HP:0010109)2.62061134
30Drooling (HP:0002307)2.61759998
31Excessive salivation (HP:0003781)2.61759998
32Cone-rod dystrophy (HP:0000548)2.58640452
33Fair hair (HP:0002286)2.53798930
34Focal motor seizures (HP:0011153)2.48945559
35Vitreoretinal degeneration (HP:0000655)2.47660038
36Aplasia/Hypoplasia of the hallux (HP:0008362)2.47240145
37Abnormality of the columella (HP:0009929)2.45243477
38Absent speech (HP:0001344)2.42487690
39Blue irides (HP:0000635)2.41625138
40Gaze-evoked nystagmus (HP:0000640)2.41560886
41Hyperventilation (HP:0002883)2.38182057
42Action tremor (HP:0002345)2.35491175
43Hypoplastic labia majora (HP:0000059)2.27128620
44Cystic liver disease (HP:0006706)2.25141359
45Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.22722675
46Long nose (HP:0003189)2.22607522
47Congenital sensorineural hearing impairment (HP:0008527)2.21609800
48Inability to walk (HP:0002540)2.21131441
49Attenuation of retinal blood vessels (HP:0007843)2.20103047
50Broad-based gait (HP:0002136)2.18582163
51Ulnar claw (HP:0001178)2.18387182
52Short 4th metacarpal (HP:0010044)2.16627645
53Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.16627645
54Type II lissencephaly (HP:0007260)2.16303036
55Preaxial foot polydactyly (HP:0001841)2.16220608
56Abolished electroretinogram (ERG) (HP:0000550)2.13221693
57Bell-shaped thorax (HP:0001591)2.13161046
58Medial flaring of the eyebrow (HP:0010747)2.13073545
59Decreased circulating renin level (HP:0003351)2.12669055
60Abnormality of alanine metabolism (HP:0010916)2.12622075
61Hyperalaninemia (HP:0003348)2.12622075
62Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.12622075
63Clumsiness (HP:0002312)2.12018597
64Abnormality of the labia majora (HP:0012881)2.10178876
65Generalized hypopigmentation of hair (HP:0011358)2.09691535
66Hemiparesis (HP:0001269)2.09217657
67Furrowed tongue (HP:0000221)2.07653854
68Abnormality of the ischium (HP:0003174)2.06853406
69Abnormality of the axillary hair (HP:0100134)2.06323452
70Abnormality of secondary sexual hair (HP:0009888)2.06323452
71Joint hemorrhage (HP:0005261)2.05239564
72Hypoplastic ischia (HP:0003175)2.05015311
73Hypoplasia of the iris (HP:0007676)2.04027280
74Widely spaced teeth (HP:0000687)2.02385762
75Morphological abnormality of the middle ear (HP:0008609)1.99885506
76Abnormality of salivation (HP:0100755)1.99702083
77Truncal obesity (HP:0001956)1.98079095
78Protruding tongue (HP:0010808)1.97885557
79White forelock (HP:0002211)1.96316477
80Scanning speech (HP:0002168)1.96306680
81Narrow palate (HP:0000189)1.93652445
82Lissencephaly (HP:0001339)1.92706039
83Broad metatarsal (HP:0001783)1.91346388
84Hypoplastic iliac wings (HP:0002866)1.89738167
85Abnormal drinking behavior (HP:0030082)1.89087876
86Polydipsia (HP:0001959)1.89087876
87Genital tract atresia (HP:0001827)1.87512927
88Renal cortical cysts (HP:0000803)1.87318929
89Limited hip movement (HP:0008800)1.86693582
90Abnormality of the incisor (HP:0000676)1.86388941
91Arthropathy (HP:0003040)1.85881840
92Concave nail (HP:0001598)1.85414321
93Bony spicule pigmentary retinopathy (HP:0007737)1.85412888
94Abnormal pancreas size (HP:0012094)1.84431151
95Parakeratosis (HP:0001036)1.84086024
96Hemiplegia (HP:0002301)1.84065791
97Infantile muscular hypotonia (HP:0008947)1.83701234
98Congenital hepatic fibrosis (HP:0002612)1.83622247
99Obstructive sleep apnea (HP:0002870)1.83140976
100Abnormality of the right ventricle (HP:0001707)1.82748673
101Stomach cancer (HP:0012126)1.81452372
102Aplasia cutis congenita (HP:0001057)1.81317709
103Gait imbalance (HP:0002141)1.81228938
104Hyperkalemia (HP:0002153)1.80758277
105Congenital, generalized hypertrichosis (HP:0004540)1.80456779
106Cutaneous finger syndactyly (HP:0010554)1.80125620
107Bulbous nose (HP:0000414)1.80086308
108Abnormality of the pubic bones (HP:0003172)1.79932849
109Absent rod-and cone-mediated responses on ERG (HP:0007688)1.79842159
110Exotropia (HP:0000577)1.78722519
111Abnormality of the phalanges of the 2nd finger (HP:0009541)1.78663956
112Alveolar cell carcinoma (HP:0006519)1.78355973
113Cerebellar dysplasia (HP:0007033)1.78277516
114Prolonged partial thromboplastin time (HP:0003645)1.78264633
115Macroorchidism (HP:0000053)1.78176210
116Prominent supraorbital ridges (HP:0000336)1.77576461
117Aqueductal stenosis (HP:0002410)1.76918736
118Short foot (HP:0001773)1.76781834
119Neoplasm of the tracheobronchial system (HP:0100552)1.76213426
120Vaginal atresia (HP:0000148)1.76055898
121Pachygyria (HP:0001302)1.75988810
122Hypophosphatemic rickets (HP:0004912)1.75799125
123Macular degeneration (HP:0000608)1.75450412
124Follicular hyperkeratosis (HP:0007502)1.74655164
125Pulmonary artery stenosis (HP:0004415)1.74479159
126Mitral stenosis (HP:0001718)1.74268992
127Craniofacial hyperostosis (HP:0004493)1.73518693
128Diplopia (HP:0000651)1.73456649
129Abnormality of binocular vision (HP:0011514)1.73456649
130Progressive inability to walk (HP:0002505)1.72762965
131Fibular hypoplasia (HP:0003038)1.72690203
132Corneal dystrophy (HP:0001131)1.72624630
133Coronal craniosynostosis (HP:0004440)1.72157873
134Short tibia (HP:0005736)1.69951809
135Aplasia/Hypoplasia of the tongue (HP:0010295)1.69841580
136Poor coordination (HP:0002370)1.69357899
137Absent frontal sinuses (HP:0002688)1.69185365
138Central scotoma (HP:0000603)1.69160940
139Median cleft lip (HP:0000161)1.69073523
140Slow saccadic eye movements (HP:0000514)1.68839826
141Agitation (HP:0000713)1.68500530
142Aplasia involving bones of the upper limbs (HP:0009823)1.68338714
143Aplasia of the phalanges of the hand (HP:0009802)1.68338714
144Aplasia involving bones of the extremities (HP:0009825)1.68338714
145Bradycardia (HP:0001662)1.68046600
146Lip pit (HP:0100267)1.67697424
147Hypoplasia of the maxilla (HP:0000327)1.67231174
148Tracheomalacia (HP:0002779)1.66918174
149Absent/shortened dynein arms (HP:0200106)1.65922424
150Dynein arm defect of respiratory motile cilia (HP:0012255)1.65922424
1512-3 toe syndactyly (HP:0004691)1.65570824
152Transitional cell carcinoma of the bladder (HP:0006740)1.65048516
153Tubulointerstitial fibrosis (HP:0005576)1.63632456
154Abnormality of the parietal bone (HP:0002696)1.63002887
155Atonic seizures (HP:0010819)1.62735598
156Patchy hypopigmentation of hair (HP:0011365)1.61812504
157Cupped ear (HP:0000378)1.61580394
158Aortic dissection (HP:0002647)1.61526336
159Congenital primary aphakia (HP:0007707)1.61300908
160Thick nail (HP:0001805)1.59337510
161Cranial hyperostosis (HP:0004437)1.58757131
162Photophobia (HP:0000613)1.58734429
163Focal seizures (HP:0007359)1.57335771
164Intellectual disability, moderate (HP:0002342)1.57069329
165Thickened helices (HP:0000391)1.54747260
166Thyroid-stimulating hormone excess (HP:0002925)1.54118887
167Overgrowth (HP:0001548)1.53873728
168Turricephaly (HP:0000262)1.53610208

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.38419638
2TNIK3.46471720
3ACVR1B2.64456363
4PNCK2.42482622
5INSRR2.39011449
6CAMK1G2.27428637
7CAMK1D2.05213471
8FGFR21.81261957
9WNK31.77865997
10PINK11.71136102
11LATS11.60172195
12IRAK41.58850281
13PRPF4B1.58650668
14SIK11.58586611
15FRK1.55872219
16IRAK21.50531299
17SGK21.47730519
18DAPK21.46286943
19NTRK31.42323999
20CLK11.41266435
21GRK11.40145777
22WNK41.39922968
23ZAK1.38283517
24WNK11.37931038
25IRAK11.33869738
26MUSK1.33004102
27EPHA31.32419047
28MKNK21.32231165
29EPHB21.31816971
30NUAK11.31641822
31MARK11.30809293
32EIF2AK21.30579168
33SIK31.27370226
34YES11.27044259
35NEK91.26581414
36PRKD21.23999331
37PIK3CA1.23714002
38NLK1.19713897
39IRAK31.19465359
40TGFBR11.18358318
41MAPK151.17250135
42BRD41.17061108
43PAK31.16856741
44MAP2K71.15059703
45SGK2231.14200117
46SGK4941.14200117
47TIE11.09413823
48FGFR31.09234489
49NEK61.08466669
50STK391.08221192
51STK381.07400553
52ADRBK11.06697057
53SGK31.05673980
54SIK21.04333172
55PKN11.02407450
56PIK3CG1.02057296
57TAOK31.00765747
58FER0.98181655
59MAP3K140.97475182
60PRKAA20.95590371
61TYRO30.94850597
62PTK2B0.93863303
63AKT30.93752573
64EPHB10.93595919
65JAK10.90624381
66PHKG10.90136677
67PHKG20.90136677
68CDK30.87894881
69ERBB30.81618753
70HIPK20.80998053
71BCR0.80294318
72TLK10.79479643
73TGFBR20.78082003
74TRPM70.77594471
75FES0.76778634
76PRKCG0.76096970
77TEC0.75738053
78SGK10.75327817
79PRKCE0.75162466
80STK30.74635671
81CAMK40.72651804
82MAP3K90.72049198
83FGR0.71984619
84MARK20.71617638
85MAPK130.71553541
86CAMKK20.70761808
87OXSR10.70661698
88MAPK70.70371018
89STK38L0.69436699
90PLK20.68900454
91NTRK20.68549945
92KIT0.67726634
93GRK70.65795824
94MAP3K70.63420962
95EPHA40.63332411
96CSNK1A1L0.61598525
97BMPR1B0.61017363
98ERBB20.60295677
99PRKG10.59192390
100DDR20.58767668
101CAMK10.58045403
102ERBB40.57795664
103UHMK10.57492591
104PDGFRB0.57482301
105CAMK2B0.55856196
106STK110.55443129
107CAMK2A0.55060737
108ROCK10.54096967
109OBSCN0.53655802
110MAP2K40.51055291
111RPS6KA60.50847125
112DMPK0.50192419
113TXK0.49432967
114CSK0.49100192
115IKBKE0.48775882
116PRKD10.48318722
117MAP3K40.46767604
118ADRBK20.46577880
119CSNK1G10.46214118
120PRKCQ0.44360816
121CDC42BPA0.43772164
122PRKAA10.43602480
123MAP2K10.43327581
124CAMK2D0.43325104
125CSNK1G20.43181529
126MELK0.42831731
127CHUK0.42547322
128MAP4K20.40536087
129MAP3K20.39265671
130PRKACA0.37967714
131STK240.37677264
132CDK50.37636899
133CAMKK10.37491080
134DYRK1A0.36839374
135PRKCH0.36322765
136CSNK1D0.34867399
137FGFR10.34687582

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.47721614
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.93880458
3Nicotine addiction_Homo sapiens_hsa050331.81128451
4Linoleic acid metabolism_Homo sapiens_hsa005911.74620265
5Axon guidance_Homo sapiens_hsa043601.50835506
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.42301436
7Glutamatergic synapse_Homo sapiens_hsa047241.40489588
8Nitrogen metabolism_Homo sapiens_hsa009101.36860366
9Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.36603361
10Steroid hormone biosynthesis_Homo sapiens_hsa001401.34438580
11Morphine addiction_Homo sapiens_hsa050321.33359858
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.29708149
13GABAergic synapse_Homo sapiens_hsa047271.28339723
14Butanoate metabolism_Homo sapiens_hsa006501.25116596
15ECM-receptor interaction_Homo sapiens_hsa045121.24215501
16Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.23834565
17Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.23006653
18Circadian rhythm_Homo sapiens_hsa047101.19777754
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19083478
20Circadian entrainment_Homo sapiens_hsa047131.16774468
21ABC transporters_Homo sapiens_hsa020101.16534226
22Complement and coagulation cascades_Homo sapiens_hsa046101.14033636
23Gastric acid secretion_Homo sapiens_hsa049711.12654896
24Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09275002
25Prostate cancer_Homo sapiens_hsa052151.09040623
26Serotonergic synapse_Homo sapiens_hsa047261.07805473
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.07293890
28Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.07187511
29Selenocompound metabolism_Homo sapiens_hsa004501.07071147
30Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.06460976
31Type II diabetes mellitus_Homo sapiens_hsa049301.06090010
32Lysine degradation_Homo sapiens_hsa003101.05850564
33Cholinergic synapse_Homo sapiens_hsa047251.02495487
34Tryptophan metabolism_Homo sapiens_hsa003801.00171902
35Choline metabolism in cancer_Homo sapiens_hsa052310.98937428
36Primary bile acid biosynthesis_Homo sapiens_hsa001200.95417678
37Long-term depression_Homo sapiens_hsa047300.95208450
38cAMP signaling pathway_Homo sapiens_hsa040240.94487016
39Basal cell carcinoma_Homo sapiens_hsa052170.92840029
40Platelet activation_Homo sapiens_hsa046110.92475947
41Focal adhesion_Homo sapiens_hsa045100.92414415
42Retinol metabolism_Homo sapiens_hsa008300.92292720
43Dorso-ventral axis formation_Homo sapiens_hsa043200.92044921
44Malaria_Homo sapiens_hsa051440.91314916
45Wnt signaling pathway_Homo sapiens_hsa043100.90861843
46Hedgehog signaling pathway_Homo sapiens_hsa043400.90734038
47Sphingolipid metabolism_Homo sapiens_hsa006000.89131024
48Staphylococcus aureus infection_Homo sapiens_hsa051500.88310545
49Ovarian steroidogenesis_Homo sapiens_hsa049130.87010022
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.86652917
51Ether lipid metabolism_Homo sapiens_hsa005650.85900693
52Taste transduction_Homo sapiens_hsa047420.85210175
53ErbB signaling pathway_Homo sapiens_hsa040120.84741623
54Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84630360
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.84377611
56Ras signaling pathway_Homo sapiens_hsa040140.83043747
57Renin secretion_Homo sapiens_hsa049240.82379646
58Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.82304964
59Melanoma_Homo sapiens_hsa052180.81353486
60Calcium signaling pathway_Homo sapiens_hsa040200.80062525
61Adherens junction_Homo sapiens_hsa045200.77832226
62Melanogenesis_Homo sapiens_hsa049160.76971464
63Aldosterone synthesis and secretion_Homo sapiens_hsa049250.76837567
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76550293
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76334509
66Dilated cardiomyopathy_Homo sapiens_hsa054140.74710987
67Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.74100742
68Salivary secretion_Homo sapiens_hsa049700.74010035
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73546374
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.73368631
71NF-kappa B signaling pathway_Homo sapiens_hsa040640.73008415
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71898585
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.71167205
74Insulin secretion_Homo sapiens_hsa049110.70598017
75Cocaine addiction_Homo sapiens_hsa050300.70559708
76Histidine metabolism_Homo sapiens_hsa003400.70157252
77Glycerolipid metabolism_Homo sapiens_hsa005610.68872075
78Hippo signaling pathway_Homo sapiens_hsa043900.67180685
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67044783
80Pancreatic secretion_Homo sapiens_hsa049720.66496928
81Estrogen signaling pathway_Homo sapiens_hsa049150.65260066
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64764883
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64654361
84Oxytocin signaling pathway_Homo sapiens_hsa049210.64323056
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64136306
86Proteoglycans in cancer_Homo sapiens_hsa052050.64095507
87PI3K-Akt signaling pathway_Homo sapiens_hsa041510.61174857
88Rap1 signaling pathway_Homo sapiens_hsa040150.61152423
89Amoebiasis_Homo sapiens_hsa051460.60981117
90Small cell lung cancer_Homo sapiens_hsa052220.60221532
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60023794
92Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59919542
93Dopaminergic synapse_Homo sapiens_hsa047280.59860063
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58099284
95MicroRNAs in cancer_Homo sapiens_hsa052060.57712668
96MAPK signaling pathway_Homo sapiens_hsa040100.57465947
97Inositol phosphate metabolism_Homo sapiens_hsa005620.57445142
98Olfactory transduction_Homo sapiens_hsa047400.56808485
99GnRH signaling pathway_Homo sapiens_hsa049120.56536750
100Protein digestion and absorption_Homo sapiens_hsa049740.55962598
101TNF signaling pathway_Homo sapiens_hsa046680.55945798
102Chemokine signaling pathway_Homo sapiens_hsa040620.55290062
103Thyroid hormone synthesis_Homo sapiens_hsa049180.54843280
104Vascular smooth muscle contraction_Homo sapiens_hsa042700.54562412
105Intestinal immune network for IgA production_Homo sapiens_hsa046720.53723657
106cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53333447
107Toll-like receptor signaling pathway_Homo sapiens_hsa046200.53318830
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52910232
109Glioma_Homo sapiens_hsa052140.52887066
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52528803
111Arachidonic acid metabolism_Homo sapiens_hsa005900.51495866
112Caffeine metabolism_Homo sapiens_hsa002320.51457199
113Chemical carcinogenesis_Homo sapiens_hsa052040.50865359
114Endometrial cancer_Homo sapiens_hsa052130.50555361
115Mineral absorption_Homo sapiens_hsa049780.50402274
116Vitamin digestion and absorption_Homo sapiens_hsa049770.50355075
117Renal cell carcinoma_Homo sapiens_hsa052110.50284433
118Pathways in cancer_Homo sapiens_hsa052000.49700531
119NOD-like receptor signaling pathway_Homo sapiens_hsa046210.49141552
120Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49024995
121TGF-beta signaling pathway_Homo sapiens_hsa043500.49022530
122Insulin resistance_Homo sapiens_hsa049310.48141916
123FoxO signaling pathway_Homo sapiens_hsa040680.47786646
124Bile secretion_Homo sapiens_hsa049760.47511522
125Fatty acid biosynthesis_Homo sapiens_hsa000610.47158801
126Osteoclast differentiation_Homo sapiens_hsa043800.47087462
127African trypanosomiasis_Homo sapiens_hsa051430.47075221
128Amphetamine addiction_Homo sapiens_hsa050310.46310564
129Long-term potentiation_Homo sapiens_hsa047200.43544275
130Gap junction_Homo sapiens_hsa045400.42443029
131Prolactin signaling pathway_Homo sapiens_hsa049170.41002368
132Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39963966

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »