HOMER2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein is a postsynaptic density scaffolding protein. Alternative splicing results in multiple transcript variants. Two related pseudogenes have been identified on chromosome 14. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)4.92733428
2bundle of His cell to Purkinje myocyte communication (GO:0086069)4.45915122
3regulation of skeletal muscle contraction (GO:0014819)4.17096601
4cell communication involved in cardiac conduction (GO:0086065)4.08996570
5ventricular cardiac muscle cell action potential (GO:0086005)4.07122280
6positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.02936320
7sensory perception of smell (GO:0007608)3.92894296
8actin-mediated cell contraction (GO:0070252)3.78710095
9regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.77327270
10response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.74930377
11regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.71526063
12cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.62421952
13vocalization behavior (GO:0071625)3.62375616
14regulation of heart rate by cardiac conduction (GO:0086091)3.57856554
15regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.48894154
16cardiac conduction (GO:0061337)3.45720229
17skeletal muscle contraction (GO:0003009)3.45576189
18fatty acid transmembrane transport (GO:1902001)3.44319210
19neuron cell-cell adhesion (GO:0007158)3.38220829
20behavioral response to nicotine (GO:0035095)3.35234681
21negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.34514305
22detection of calcium ion (GO:0005513)3.34481133
23glutamate secretion (GO:0014047)3.32656526
24cardiac muscle contraction (GO:0060048)3.31387032
25membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.29694860
26cardiac myofibril assembly (GO:0055003)3.28796293
27cell communication by electrical coupling (GO:0010644)3.27670970
28regulation of short-term neuronal synaptic plasticity (GO:0048172)3.22048520
29regulation of cell communication by electrical coupling (GO:0010649)3.16960454
30cardiac muscle cell action potential (GO:0086001)3.15373282
31cardiac muscle cell action potential involved in contraction (GO:0086002)3.14343663
32response to muscle activity (GO:0014850)3.12526932
33cardiac muscle hypertrophy (GO:0003300)3.08157124
34regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.05928569
35regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.04455445
36otic vesicle formation (GO:0030916)3.04407978
37positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.04153076
38regulation of membrane repolarization (GO:0060306)3.03951343
39carnitine transmembrane transport (GO:1902603)3.03335746
40negative regulation of potassium ion transmembrane transport (GO:1901380)3.02580187
41drug catabolic process (GO:0042737)3.00760747
42prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.00491973
43membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.95179630
44striated muscle hypertrophy (GO:0014897)2.95041114
45skeletal muscle adaptation (GO:0043501)2.94545117
46branching involved in prostate gland morphogenesis (GO:0060442)2.93926996
47oxidative demethylation (GO:0070989)2.93586695
48amino-acid betaine transport (GO:0015838)2.91763357
49carnitine transport (GO:0015879)2.91763357
50interkinetic nuclear migration (GO:0022027)2.91274275
51chemosensory behavior (GO:0007635)2.89057393
52myotube cell development (GO:0014904)2.87521812
53regulation of glutamate receptor signaling pathway (GO:1900449)2.86501290
54regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.86453838
55synaptic vesicle exocytosis (GO:0016079)2.84944168
56exogenous drug catabolic process (GO:0042738)2.82439397
57sarcomere organization (GO:0045214)2.82241250
58positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.80642563
59regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.80394705
60plasma membrane repair (GO:0001778)2.80256127
61myofibril assembly (GO:0030239)2.77350294
62neuron recognition (GO:0008038)2.77286121
63regulation of hippo signaling (GO:0035330)2.76954945
64protein localization to synapse (GO:0035418)2.76396279
65positive regulation of fatty acid oxidation (GO:0046321)2.75696660
66muscle fiber development (GO:0048747)2.74913760
67skeletal muscle fiber development (GO:0048741)2.74859369
68multicellular organismal signaling (GO:0035637)2.74093480
69regulation of acrosome reaction (GO:0060046)2.72404418
70cellular ketone body metabolic process (GO:0046950)2.71581486
71synaptic vesicle docking involved in exocytosis (GO:0016081)2.70559067
72actomyosin structure organization (GO:0031032)2.70140544
73axonal fasciculation (GO:0007413)2.70077082
74relaxation of cardiac muscle (GO:0055119)2.70041241
75regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.69888760
76kynurenine metabolic process (GO:0070189)2.69342301
77quaternary ammonium group transport (GO:0015697)2.68802140
78neurotransmitter-gated ion channel clustering (GO:0072578)2.68288192
79tryptophan catabolic process (GO:0006569)2.67785186
80indole-containing compound catabolic process (GO:0042436)2.67785186
81indolalkylamine catabolic process (GO:0046218)2.67785186
82sarcoplasmic reticulum calcium ion transport (GO:0070296)2.66735591
83positive regulation of potassium ion transmembrane transport (GO:1901381)2.66071325
84dendritic spine morphogenesis (GO:0060997)2.65642320
85response to inactivity (GO:0014854)2.65199725
86actin filament-based movement (GO:0030048)2.64454156
87ionotropic glutamate receptor signaling pathway (GO:0035235)2.64153012
88intestinal cholesterol absorption (GO:0030299)2.63860828
89positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.63451858
90striated muscle contraction (GO:0006941)2.62687046
91membrane repolarization during action potential (GO:0086011)2.62637699
92pyrimidine nucleobase catabolic process (GO:0006208)2.61421332
93aromatic amino acid family catabolic process (GO:0009074)2.60934619
94regulation of synapse structural plasticity (GO:0051823)2.57260651
95muscle cell fate commitment (GO:0042693)2.57126175
96locomotory exploration behavior (GO:0035641)2.56576367
97membrane depolarization during action potential (GO:0086010)2.56477680
98gamma-aminobutyric acid transport (GO:0015812)2.55541375
99regulation of acyl-CoA biosynthetic process (GO:0050812)2.54986715
100regulation of sarcomere organization (GO:0060297)2.54973922
101ketone body metabolic process (GO:1902224)2.54232634
102regulation of the force of heart contraction (GO:0002026)2.53405502
103negative regulation of protein localization to cell surface (GO:2000009)2.53155422
104regulation of heart rate (GO:0002027)2.53100812
105epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.53004004
106positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.52292160
107muscle contraction (GO:0006936)2.52125524
108reflex (GO:0060004)2.51305956
109regulation of long-term neuronal synaptic plasticity (GO:0048169)2.50514243
110mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.50429426
111negative regulation of cytosolic calcium ion concentration (GO:0051481)2.50420754
112cardiac muscle adaptation (GO:0014887)2.50217888
113cardiac muscle hypertrophy in response to stress (GO:0014898)2.50217888
114muscle hypertrophy in response to stress (GO:0003299)2.50217888
115carnitine shuttle (GO:0006853)2.50017421
116regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.49840904
117regulation of glucokinase activity (GO:0033131)2.49834278
118regulation of hexokinase activity (GO:1903299)2.49834278
119muscle hypertrophy (GO:0014896)2.49712097
120pharyngeal system development (GO:0060037)2.48458042
121layer formation in cerebral cortex (GO:0021819)2.46421791
122actin-myosin filament sliding (GO:0033275)2.46254485
123muscle filament sliding (GO:0030049)2.46254485
124regulation of neuronal synaptic plasticity (GO:0048168)2.46203039
125neurotransmitter secretion (GO:0007269)2.45604522
126striated muscle atrophy (GO:0014891)2.44555277
127regulation of sodium ion transmembrane transporter activity (GO:2000649)2.44440900
128neuromuscular synaptic transmission (GO:0007274)2.43511493
129female mating behavior (GO:0060180)2.42138178
130exploration behavior (GO:0035640)2.41780580
131regulation of female receptivity (GO:0045924)2.41678485
132epithelial cell maturation (GO:0002070)2.41568488
133neuronal action potential propagation (GO:0019227)2.41036582
134regulation of relaxation of muscle (GO:1901077)2.40562714
135regulation of actin filament-based movement (GO:1903115)2.40385406
136regulation of striated muscle contraction (GO:0006942)2.39721793
137nucleobase catabolic process (GO:0046113)2.38947895
138erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.38469758
139L-phenylalanine catabolic process (GO:0006559)2.38469758
140synaptic transmission, glutamatergic (GO:0035249)2.37227275
141regulation of action potential (GO:0098900)2.36823894
142regulation of fatty acid oxidation (GO:0046320)2.36541131
143indolalkylamine metabolic process (GO:0006586)2.35975776
144striated muscle adaptation (GO:0014888)2.35866586
145muscle system process (GO:0003012)2.35838302
146adult heart development (GO:0007512)2.35320776
147positive regulation of glycolytic process (GO:0045821)2.34982944
148action potential (GO:0001508)2.34689894
149* glutamate receptor signaling pathway (GO:0007215)2.34126215
150myoblast fusion (GO:0007520)2.34038690
151cell migration in hindbrain (GO:0021535)2.33189408
152detection of light stimulus involved in sensory perception (GO:0050962)2.32901291
153detection of light stimulus involved in visual perception (GO:0050908)2.32901291
154positive regulation of synapse maturation (GO:0090129)2.32675286
155serotonin metabolic process (GO:0042428)2.32591900
156short-chain fatty acid metabolic process (GO:0046459)2.32375802
157positive regulation of cation channel activity (GO:2001259)2.31646066
158regulation of sequestering of triglyceride (GO:0010889)2.31563785
159regulation of synaptic vesicle exocytosis (GO:2000300)2.30823502
160myotube differentiation (GO:0014902)2.30569150
161calcium ion import (GO:0070509)2.29642325
162erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.29328878
163L-phenylalanine metabolic process (GO:0006558)2.29328878
164glyoxylate metabolic process (GO:0046487)2.28356408
165response to caffeine (GO:0031000)2.23732319
166primary amino compound metabolic process (GO:1901160)2.23581873
167regulation of potassium ion transmembrane transporter activity (GO:1901016)2.23578725
168biotin metabolic process (GO:0006768)2.22101662
169righting reflex (GO:0060013)2.21897747
170piRNA metabolic process (GO:0034587)2.21847322
171tryptophan metabolic process (GO:0006568)2.21606801

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.57477356
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.09034987
3GBX2_23144817_ChIP-Seq_PC3_Human2.67671325
4* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.42252462
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.39677412
6* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.32051944
7IGF1R_20145208_ChIP-Seq_DFB_Human2.25544542
8* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.21744369
9* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.21744369
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.17443906
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.13127084
12* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.07887306
13TAF15_26573619_Chip-Seq_HEK293_Human2.07787149
14* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.04677859
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.04407097
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.03523921
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.95338629
18RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.92953576
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.92284917
20DROSHA_22980978_ChIP-Seq_HELA_Human1.90828854
21* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.89258622
22EZH2_27294783_Chip-Seq_ESCs_Mouse1.84001578
23SUZ12_27294783_Chip-Seq_ESCs_Mouse1.77564538
24RNF2_27304074_Chip-Seq_ESCs_Mouse1.74905799
25ER_23166858_ChIP-Seq_MCF-7_Human1.74200315
26ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.71864188
27FUS_26573619_Chip-Seq_HEK293_Human1.69951817
28* REST_21632747_ChIP-Seq_MESCs_Mouse1.67169302
29SMAD4_21799915_ChIP-Seq_A2780_Human1.53405687
30* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.51862803
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49530453
32EP300_21415370_ChIP-Seq_HL-1_Mouse1.48652544
33IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47770807
34CBP_20019798_ChIP-Seq_JUKART_Human1.47770807
35MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46803441
36AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.46539299
37* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.45042024
38AR_21572438_ChIP-Seq_LNCaP_Human1.44803036
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43657149
40FOXM1_26456572_ChIP-Seq_MCF-7_Human1.43247169
41FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.42885132
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.42833337
43AHR_22903824_ChIP-Seq_MCF-7_Human1.42452548
44ERG_21242973_ChIP-ChIP_JURKAT_Human1.42281331
45ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.40371051
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39219236
47ESR1_20079471_ChIP-ChIP_T-47D_Human1.38625763
48NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.37854440
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.36499833
50BCAT_22108803_ChIP-Seq_LS180_Human1.36492468
51CDX2_19796622_ChIP-Seq_MESCs_Mouse1.35847731
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.33968698
53RARB_27405468_Chip-Seq_BRAIN_Mouse1.32975273
54RBPJ_22232070_ChIP-Seq_NCS_Mouse1.32556665
55ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.31833625
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31097039
57BMI1_23680149_ChIP-Seq_NPCS_Mouse1.30594349
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.30037320
59REST_18959480_ChIP-ChIP_MESCs_Mouse1.29695394
60P300_19829295_ChIP-Seq_ESCs_Human1.29637681
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28939180
62NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.28898285
63ZNF263_19887448_ChIP-Seq_K562_Human1.28438786
64PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.28196268
65VDR_22108803_ChIP-Seq_LS180_Human1.28076905
66CTBP2_25329375_ChIP-Seq_LNCAP_Human1.26739963
67TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.26095282
68SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25985717
69ZNF274_21170338_ChIP-Seq_K562_Hela1.25972625
70ARNT_22903824_ChIP-Seq_MCF-7_Human1.25744800
71RXR_22158963_ChIP-Seq_LIVER_Mouse1.25081169
72GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24338721
73* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23221478
74RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20092774
75TP53_18474530_ChIP-ChIP_U2OS_Human1.19449361
76* LXR_22158963_ChIP-Seq_LIVER_Mouse1.18690383
77FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.17769588
78EWS_26573619_Chip-Seq_HEK293_Human1.16152052
79ESR1_21235772_ChIP-Seq_MCF-7_Human1.15435331
80EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14476427
81NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14110595
82FOXA1_25552417_ChIP-Seq_VCAP_Human1.13864263
83* SOX2_21211035_ChIP-Seq_LN229_Gbm1.13853775
84* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13130038
85EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.10731214
86PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10389703
87FLI1_27457419_Chip-Seq_LIVER_Mouse1.09912147
88* ESR2_21235772_ChIP-Seq_MCF-7_Human1.08910473
89RING1B_27294783_Chip-Seq_ESCs_Mouse1.08883639
90* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08455497
91NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08434476
92AR_25329375_ChIP-Seq_VCAP_Human1.08112572
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07753383
94GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.07511122
95KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07226525
96AR_19668381_ChIP-Seq_PC3_Human1.06992248
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05520901
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05520901
99CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04467762
100OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03143413
101WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03022572
102POU3F2_20337985_ChIP-ChIP_501MEL_Human1.01943300
103FLI1_21867929_ChIP-Seq_TH2_Mouse1.01898844
104STAT3_23295773_ChIP-Seq_U87_Human1.01898812
105TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00947370
106CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00663508
107EGR1_23403033_ChIP-Seq_LIVER_Mouse0.99396876
108CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98954011
109SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98801829
110TP53_16413492_ChIP-PET_HCT116_Human0.98563637
111OCT1_27270436_Chip-Seq_PROSTATE_Human0.98212358
112RXR_22108803_ChIP-Seq_LS180_Human0.98209489
113* SMAD4_21741376_ChIP-Seq_HESCs_Human0.97980100
114PPARA_22158963_ChIP-Seq_LIVER_Mouse0.97190266
115CDX2_22108803_ChIP-Seq_LS180_Human0.96946244
116HTT_18923047_ChIP-ChIP_STHdh_Human0.95706159
117SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94598863
118BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93726879
119SMAD3_21741376_ChIP-Seq_HESCs_Human0.93581704
120PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92190498
121RUNX2_22187159_ChIP-Seq_PCA_Human0.91167987
122TCF4_18268006_ChIP-ChIP_LS174T_Human0.90893694
123TCF4_23295773_ChIP-Seq_U87_Human0.90367937
124MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88983688
125RING1B_27294783_Chip-Seq_NPCs_Mouse0.88636512
126* PRDM14_20953172_ChIP-Seq_ESCs_Human0.87873462
127TCF4_22108803_ChIP-Seq_LS180_Human0.87654741
128CTCF_27219007_Chip-Seq_Bcells_Human0.87527406
129SMAD4_21741376_ChIP-Seq_EPCs_Human0.86435893
130RNF2_27304074_Chip-Seq_NSC_Mouse0.86418455
131CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.86022610
132TP63_17297297_ChIP-ChIP_HaCaT_Human0.85903764
133TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.85724609

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001984_abnormal_olfaction3.66906440
2MP0004859_abnormal_synaptic_plasticity3.64367431
3MP0002837_dystrophic_cardiac_calcinosis3.50880719
4MP0003880_abnormal_central_pattern2.83744578
5MP0005085_abnormal_gallbladder_physiolo2.50358668
6MP0004215_abnormal_myocardial_fiber2.44882094
7MP0000751_myopathy2.44233978
8MP0004270_analgesia2.37232340
9MP0003646_muscle_fatigue2.33516964
10MP0010234_abnormal_vibrissa_follicle2.32642948
11MP0003635_abnormal_synaptic_transmissio2.31872829
12MP0002139_abnormal_hepatobiliary_system2.21695054
13MP0005365_abnormal_bile_salt2.18042997
14MP0005360_urolithiasis2.12560618
15MP0002796_impaired_skin_barrier1.97990486
16MP0004084_abnormal_cardiac_muscle1.95703141
17MP0003941_abnormal_skin_development1.91299228
18* MP0002063_abnormal_learning/memory/cond1.90431692
19MP0004145_abnormal_muscle_electrophysio1.83218175
20MP0001968_abnormal_touch/_nociception1.82393006
21MP0003195_calcinosis1.80475683
22MP0001666_abnormal_nutrient_absorption1.77501797
23MP0004043_abnormal_pH_regulation1.76843849
24* MP0009745_abnormal_behavioral_response1.75293089
25MP0005083_abnormal_biliary_tract1.74518205
26MP0004036_abnormal_muscle_relaxation1.73364859
27MP0004484_altered_response_of1.68520054
28MP0005451_abnormal_body_composition1.67924699
29MP0008875_abnormal_xenobiotic_pharmacok1.67497806
30MP0005670_abnormal_white_adipose1.66362531
31MP0005330_cardiomyopathy1.65057277
32MP0003137_abnormal_impulse_conducting1.64353837
33MP0002734_abnormal_mechanical_nocicepti1.64283377
34MP0005394_taste/olfaction_phenotype1.60807254
35MP0005499_abnormal_olfactory_system1.60807254
36MP0008789_abnormal_olfactory_epithelium1.60363288
37MP0003011_delayed_dark_adaptation1.59902873
38MP0002735_abnormal_chemical_nociception1.58811268
39MP0002138_abnormal_hepatobiliary_system1.55287248
40MP0002184_abnormal_innervation1.55226081
41MP0004085_abnormal_heartbeat1.54535872
42MP0001486_abnormal_startle_reflex1.54006662
43MP0002064_seizures1.52244939
44MP0002736_abnormal_nociception_after1.51731647
45MP0002822_catalepsy1.50911263
46MP0006276_abnormal_autonomic_nervous1.50662281
47MP0002572_abnormal_emotion/affect_behav1.49656168
48MP0002972_abnormal_cardiac_muscle1.46752700
49MP0000749_muscle_degeneration1.44337437
50MP0005620_abnormal_muscle_contractility1.43430921
51MP0002272_abnormal_nervous_system1.43183140
52MP0002160_abnormal_reproductive_system1.39877023
53MP0000778_abnormal_nervous_system1.38796095
54MP0005187_abnormal_penis_morphology1.35924186
55MP0002876_abnormal_thyroid_physiology1.35256081
56MP0009046_muscle_twitch1.32653233
57MP0005645_abnormal_hypothalamus_physiol1.31619482
58MP0000383_abnormal_hair_follicle1.28436063
59MP0004858_abnormal_nervous_system1.27486039
60MP0009780_abnormal_chondrocyte_physiolo1.26328938
61MP0002557_abnormal_social/conspecific_i1.23196898
62MP0002108_abnormal_muscle_morphology1.18142677
63MP0005423_abnormal_somatic_nervous1.16942498
64MP0008775_abnormal_heart_ventricle1.15999512
65MP0000759_abnormal_skeletal_muscle1.15987648
66MP0004087_abnormal_muscle_fiber1.15132874
67MP0004130_abnormal_muscle_cell1.13773758
68MP0002067_abnormal_sensory_capabilities1.13540866
69MP0005551_abnormal_eye_electrophysiolog1.11330886
70MP0001661_extended_life_span1.11237677
71MP0001440_abnormal_grooming_behavior1.08304411
72MP0002638_abnormal_pupillary_reflex1.06975562
73MP0010678_abnormal_skin_adnexa1.06361940
74MP0003879_abnormal_hair_cell1.05541051
75MP0002332_abnormal_exercise_endurance1.04258335
76MP0003868_abnormal_feces_composition1.04062631
77MP0000579_abnormal_nail_morphology1.03783252
78MP0000537_abnormal_urethra_morphology1.03533263
79MP0000750_abnormal_muscle_regeneration1.01920975
80MP0000631_abnormal_neuroendocrine_gland1.01377794
81MP0003252_abnormal_bile_duct1.01205055
82MP0001501_abnormal_sleep_pattern1.01168820
83MP0004233_abnormal_muscle_weight1.00935437
84MP0005220_abnormal_exocrine_pancreas0.99799153
85MP0004885_abnormal_endolymph0.97814653
86MP0000733_abnormal_muscle_development0.96607854
87MP0001970_abnormal_pain_threshold0.96386706
88MP0010329_abnormal_lipoprotein_level0.95973314
89MP0002733_abnormal_thermal_nociception0.95820020
90MP0003136_yellow_coat_color0.95612228
91MP0003890_abnormal_embryonic-extraembry0.95605785
92MP0002106_abnormal_muscle_physiology0.95513160
93MP0000566_synostosis0.94620384
94MP0010386_abnormal_urinary_bladder0.93860097
95MP0006138_congestive_heart_failure0.93466677
96MP0001485_abnormal_pinna_reflex0.93454966
97MP0002909_abnormal_adrenal_gland0.90230585
98MP0004924_abnormal_behavior0.90068349
99MP0005386_behavior/neurological_phenoty0.90068349
100MP0008872_abnormal_physiological_respon0.89921109
101MP0005647_abnormal_sex_gland0.89897541
102MP0001544_abnormal_cardiovascular_syste0.89687373
103MP0005385_cardiovascular_system_phenoty0.89687373
104MP0004134_abnormal_chest_morphology0.88845872
105MP0003329_amyloid_beta_deposits0.86550256
106MP0004381_abnormal_hair_follicle0.85470308
107MP0000569_abnormal_digit_pigmentation0.85442317
108MP0002102_abnormal_ear_morphology0.85238560
109MP0002882_abnormal_neuron_morphology0.84980668
110MP0004811_abnormal_neuron_physiology0.84747631
111MP0005410_abnormal_fertilization0.83897218
112MP0005332_abnormal_amino_acid0.81049937
113MP0000372_irregular_coat_pigmentation0.80096797
114MP0005646_abnormal_pituitary_gland0.79901144
115MP0003718_maternal_effect0.78441371
116MP0000538_abnormal_urinary_bladder0.77024785
117MP0000747_muscle_weakness0.76717069
118MP0005369_muscle_phenotype0.76706079
119MP0002269_muscular_atrophy0.76657214
120MP0005501_abnormal_skin_physiology0.74802301
121MP0001188_hyperpigmentation0.74353416
122MP0005266_abnormal_metabolism0.74242244
123MP0000955_abnormal_spinal_cord0.73190182
124MP0005248_abnormal_Harderian_gland0.72615148
125MP0006036_abnormal_mitochondrial_physio0.72504620
126MP0002078_abnormal_glucose_homeostasis0.72423301
127MP0002118_abnormal_lipid_homeostasis0.71926412
128MP0002127_abnormal_cardiovascular_syste0.71900829
129MP0001944_abnormal_pancreas_morphology0.71639531
130MP0001664_abnormal_digestion0.71405803
131MP0005535_abnormal_body_temperature0.71034281
132MP0002234_abnormal_pharynx_morphology0.71013520
133MP0002066_abnormal_motor_capabilities/c0.70935271
134MP0010630_abnormal_cardiac_muscle0.70011882
135MP0003878_abnormal_ear_physiology0.69009081
136MP0005377_hearing/vestibular/ear_phenot0.69009081
137MP0006035_abnormal_mitochondrial_morpho0.68802196
138MP0004142_abnormal_muscle_tone0.68316424
139MP0001502_abnormal_circadian_rhythm0.68109832
140MP0000427_abnormal_hair_cycle0.65258079
141MP0004510_myositis0.65193978
142MP0001346_abnormal_lacrimal_gland0.64643917

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)6.00062195
2Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.72569941
3Nemaline bodies (HP:0003798)5.67135575
4Sudden death (HP:0001699)5.55090981
5Right ventricular cardiomyopathy (HP:0011663)4.96344111
6Syncope (HP:0001279)4.65482278
7Focal motor seizures (HP:0011153)4.19534956
8Calf muscle hypertrophy (HP:0008981)4.13126923
9Ventricular fibrillation (HP:0001663)4.05052186
10Ventricular tachycardia (HP:0004756)3.89068603
11Muscle hypertrophy of the lower extremities (HP:0008968)3.85142724
12Atrial fibrillation (HP:0005110)3.71784198
13Primary atrial arrhythmia (HP:0001692)3.63795161
14Exercise-induced myalgia (HP:0003738)3.63383751
15Supraventricular tachycardia (HP:0004755)3.44412104
16Type 1 muscle fiber predominance (HP:0003803)3.43028672
17Prolonged QT interval (HP:0001657)3.38376967
18Supraventricular arrhythmia (HP:0005115)3.32282077
19Palpitations (HP:0001962)3.31213082
20Abnormality of the calf musculature (HP:0001430)3.30129093
21Ventricular arrhythmia (HP:0004308)3.22568869
22Febrile seizures (HP:0002373)3.22065687
23Focal seizures (HP:0007359)3.20806317
24Atonic seizures (HP:0010819)3.14643330
25Hyporeflexia of lower limbs (HP:0002600)3.13057043
26Myokymia (HP:0002411)3.11070439
27Hyperventilation (HP:0002883)3.09061468
28Distal arthrogryposis (HP:0005684)2.95943304
29Absence seizures (HP:0002121)2.91914476
30Hyperkalemia (HP:0002153)2.85552053
31Generalized tonic-clonic seizures (HP:0002069)2.78822758
32Visual hallucinations (HP:0002367)2.75111884
33Abnormal EKG (HP:0003115)2.71989808
34Bundle branch block (HP:0011710)2.71625302
35Pancreatic cysts (HP:0001737)2.61786209
36Lip pit (HP:0100267)2.55378914
37Dialeptic seizures (HP:0011146)2.55258027
38Popliteal pterygium (HP:0009756)2.53973759
39Hyperglycinemia (HP:0002154)2.49848672
40Ketosis (HP:0001946)2.47428773
41Myopathic facies (HP:0002058)2.45507039
42Acute necrotizing encephalopathy (HP:0006965)2.42443135
43Frequent falls (HP:0002359)2.41354919
44Epileptic encephalopathy (HP:0200134)2.41205945
45Ketoacidosis (HP:0001993)2.39388891
46Cerebral edema (HP:0002181)2.39298864
47Acute encephalopathy (HP:0006846)2.35600605
48Absent phalangeal crease (HP:0006109)2.30272369
49Heart block (HP:0012722)2.30253767
50Exercise-induced muscle cramps (HP:0003710)2.30187047
51Progressive cerebellar ataxia (HP:0002073)2.28986500
52Lipoatrophy (HP:0100578)2.28286210
53EMG: myopathic abnormalities (HP:0003458)2.27476411
54Anosmia (HP:0000458)2.26516891
55Abnormality of the renal cortex (HP:0011035)2.26191434
56Progressive macrocephaly (HP:0004481)2.26167129
57Abnormal mitochondria in muscle tissue (HP:0008316)2.24513835
58Conjunctival hamartoma (HP:0100780)2.20545768
59Fetal akinesia sequence (HP:0001989)2.16309425
60Abnormal atrioventricular conduction (HP:0005150)2.16179090
61Deep venous thrombosis (HP:0002625)2.15414237
62Palmoplantar keratoderma (HP:0000982)2.14364543
63Double outlet right ventricle (HP:0001719)2.14208118
64Congenital malformation of the right heart (HP:0011723)2.14208118
65Myoglobinuria (HP:0002913)2.11093426
66Nephronophthisis (HP:0000090)2.10913754
67Abnormality of secondary sexual hair (HP:0009888)2.10191557
68Abnormality of the axillary hair (HP:0100134)2.10191557
69Rhabdomyolysis (HP:0003201)2.08424155
70Atrioventricular block (HP:0001678)2.07521955
71Type II lissencephaly (HP:0007260)2.07475476
72Intrahepatic cholestasis (HP:0001406)2.06250987
73Abnormality of the neuromuscular junction (HP:0003398)2.05728880
74Fatigable weakness (HP:0003473)2.05728880
75Neck muscle weakness (HP:0000467)2.04983789
76Abnormality of the left ventricular outflow tract (HP:0011103)2.01049874
77Subaortic stenosis (HP:0001682)2.01049874
78Left ventricular hypertrophy (HP:0001712)1.99190206
79Pancreatic fibrosis (HP:0100732)1.98242258
80Dilated cardiomyopathy (HP:0001644)1.96684335
81Abnormality of the renal medulla (HP:0100957)1.96097213
82Chronic hepatic failure (HP:0100626)1.95993637
83Abnormality of aromatic amino acid family metabolism (HP:0004338)1.95838436
84Dysmetric saccades (HP:0000641)1.95450289
85Prolonged partial thromboplastin time (HP:0003645)1.94917219
86Hyperlipoproteinemia (HP:0010980)1.94807077
87Hypobetalipoproteinemia (HP:0003563)1.93184556
88Decreased circulating renin level (HP:0003351)1.90169791
89Abnormal finger flexion creases (HP:0006143)1.89981615
90Hypoalphalipoproteinemia (HP:0003233)1.88154133
91Muscle fiber splitting (HP:0003555)1.87840110
92Testicular atrophy (HP:0000029)1.86916712
93Hyperammonemia (HP:0001987)1.86756162
94Abnormality of midbrain morphology (HP:0002418)1.86077327
95Molar tooth sign on MRI (HP:0002419)1.86077327
96Hyperglycinuria (HP:0003108)1.85778238
97Malignant hyperthermia (HP:0002047)1.85455245
98Abnormality of serine family amino acid metabolism (HP:0010894)1.82433388
99Abnormality of glycine metabolism (HP:0010895)1.82433388
100Absent eyebrow (HP:0002223)1.82132691
101Areflexia of lower limbs (HP:0002522)1.82104428
102True hermaphroditism (HP:0010459)1.81334600
103Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.80778773
104Abnormality of alanine metabolism (HP:0010916)1.80778773
105Hyperalaninemia (HP:0003348)1.80778773
106EMG: neuropathic changes (HP:0003445)1.79863237
107Clumsiness (HP:0002312)1.79472020
108Dysdiadochokinesis (HP:0002075)1.79313334
109Nonprogressive disorder (HP:0003680)1.79218220
110Fair hair (HP:0002286)1.79114658
111Broad-based gait (HP:0002136)1.78993639
112Hypolipoproteinemia (HP:0010981)1.78772715
113Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.78665316
114Short 1st metacarpal (HP:0010034)1.78665316
115Epidermoid cyst (HP:0200040)1.78041491
116Pheochromocytoma (HP:0002666)1.76510446
117Hamartoma of the eye (HP:0010568)1.75933839
118Amelogenesis imperfecta (HP:0000705)1.75678605
119Ulnar deviation of the wrist (HP:0003049)1.74870995
120Myotonia (HP:0002486)1.74572946
121Abnormality of the parathyroid morphology (HP:0011766)1.73883932
122Impaired vibration sensation in the lower limbs (HP:0002166)1.71515167
123Tubular atrophy (HP:0000092)1.71195380
124Status epilepticus (HP:0002133)1.71085342
125Abnormality of potassium homeostasis (HP:0011042)1.70064173
126Xanthomatosis (HP:0000991)1.68993401
127Amblyopia (HP:0000646)1.68307061
128Depressed nasal tip (HP:0000437)1.67874911
129Genetic anticipation (HP:0003743)1.67820356
130Mitochondrial inheritance (HP:0001427)1.67700536
131Anxiety (HP:0000739)1.67447472
132Bradycardia (HP:0001662)1.66316991
133Round ear (HP:0100830)1.66271500
134Urinary bladder sphincter dysfunction (HP:0002839)1.66226459
135Proximal amyotrophy (HP:0007126)1.64656569
136Ragged-red muscle fibers (HP:0003200)1.64579760
137Metabolic acidosis (HP:0001942)1.64559046
138Limb dystonia (HP:0002451)1.64538583
139Renal cortical cysts (HP:0000803)1.63893760
140Conjugated hyperbilirubinemia (HP:0002908)1.63352478
141Azoospermia (HP:0000027)1.62860120
142Generalized myoclonic seizures (HP:0002123)1.62151880
143Epileptiform EEG discharges (HP:0011182)1.61911614
144Cystic liver disease (HP:0006706)1.61909200
145Muscular dystrophy (HP:0003560)1.61075329
146Large for gestational age (HP:0001520)1.60824064
147Abnormality of the labia majora (HP:0012881)1.59964073
148Difficulty running (HP:0009046)1.58669723
149Furrowed tongue (HP:0000221)1.58608927
150Progressive inability to walk (HP:0002505)1.58456366
151Drooling (HP:0002307)1.58359710
152Excessive salivation (HP:0003781)1.58359710
153Rimmed vacuoles (HP:0003805)1.58353663
154Curly hair (HP:0002212)1.57995895
155Enlarged kidneys (HP:0000105)1.57785631
156Gaze-evoked nystagmus (HP:0000640)1.57534093
157Abnormal pancreas size (HP:0012094)1.57147033
158Distal lower limb muscle weakness (HP:0009053)1.56334604
159Dynein arm defect of respiratory motile cilia (HP:0012255)1.55812918
160Absent/shortened dynein arms (HP:0200106)1.55812918
161Protruding tongue (HP:0010808)1.53452198
162Bulbar palsy (HP:0001283)1.52918225
163Medial flaring of the eyebrow (HP:0010747)1.51653027

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA43.42583004
2OBSCN3.32507909
3NTRK32.78575606
4PHKG22.75758352
5PHKG12.75758352
6MAP3K42.50819992
7MARK12.49327288
8CAMK1D2.34419987
9CAMK1G2.34284015
10MAP3K92.28588712
11CASK2.26784087
12MAP2K72.24594575
13MAP2K42.22248905
14DAPK22.05139287
15BMPR1B1.99730452
16LMTK21.88959581
17BCKDK1.88551280
18STK241.83269633
19MINK11.80949085
20ADRBK21.64510832
21ACVR1B1.62648016
22GRK11.56863528
23EEF2K1.54767541
24STK38L1.44711507
25NTRK21.43605056
26FER1.42056270
27PAK31.41997593
28MAPK131.41727772
29TNK21.33612818
30WNK41.30267380
31DMPK1.28526461
32CAMK2A1.28054309
33PLK21.26797256
34GRK51.21783280
35STK381.21068329
36FGFR21.18174818
37PIK3CG1.15468270
38CAMK2D1.13997502
39ERBB31.12407649
40PAK61.10296010
41PRKCG1.09817461
42PINK11.07420535
43KSR11.06459430
44LATS21.06297449
45MYLK1.05728738
46FRK1.04731586
47CAMK2B1.03462004
48MAPKAPK31.03252929
49MAP3K71.02959820
50PNCK1.00316127
51PIK3CA0.99159114
52PKN20.98391704
53NME10.98103548
54MUSK0.96707537
55CDK50.95977613
56PDK30.95303439
57PDK40.95303439
58TAOK30.94629331
59BMPR20.93689632
60SGK20.93329846
61KSR20.92791870
62TRPM70.92635401
63DYRK1A0.88863683
64SIK20.87245322
65AKT30.86803524
66CAMK2G0.85600655
67MAP3K20.83688009
68INSRR0.82997444
69SGK2230.82140685
70SGK4940.82140685
71ARAF0.81142037
72MAP3K120.78772320
73OXSR10.77303731
74PRPF4B0.76744108
75CAMKK10.75712360
76PRKCE0.73850164
77MAPK120.73373736
78CSNK1G20.72324643
79TTN0.71197119
80RIPK40.70319993
81EPHB20.70262181
82MAPK150.70171402
83GRK70.69257162
84CAMK10.69023081
85NEK10.68851632
86TNIK0.68694777
87MAP2K10.67651620
88TLK10.66677325
89PRKCZ0.64493090
90PRKCI0.64481781
91PKN10.63944317
92CSNK1G10.63155196
93NTRK10.63062265
94STK110.62592025
95PRKD30.61868438
96NUAK10.61690129
97CDC42BPA0.61321393
98MAP3K50.60607012
99MAP4K20.60257116
100BRAF0.59516142
101PTK2B0.59312982
102DAPK10.59244199
103CAMK40.59068678
104SGK10.58677946
105RPS6KB10.56876092
106TAOK10.55922231
107SGK30.55788809
108NLK0.55671696
109PRKAA20.55409793
110ROCK10.55264978
111LATS10.53449652
112CSNK1A1L0.53428470
113RET0.53087421
114TRIB30.52935120
115PRKAA10.52637115
116CSNK1G30.52029523
117BCR0.51059828
118STK390.49991711
119ILK0.49905378
120MARK20.49776080
121PRKACA0.49412382
122MAP2K60.48737831
123AKT20.48504055
124RIPK10.47473452
125ERBB40.46644004
126RPS6KA20.45407821
127PRKG10.45352123
128MAP3K60.45280311
129ADRBK10.44941534
130WNK30.44920471
131CSNK1D0.43277719
132MKNK20.42024875
133MTOR0.40232036
134TRIM280.36825315
135STK30.34982487
136WNK10.34386104
137TGFBR10.34276659
138RPS6KA30.34197517
139MARK30.31685919

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047402.91444673
2Circadian rhythm_Homo sapiens_hsa047102.29662036
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.19214009
4Nicotine addiction_Homo sapiens_hsa050332.18384584
5Cardiac muscle contraction_Homo sapiens_hsa042602.13459936
6Linoleic acid metabolism_Homo sapiens_hsa005912.06955848
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.93611871
8Propanoate metabolism_Homo sapiens_hsa006401.77886656
9Circadian entrainment_Homo sapiens_hsa047131.76431427
10Maturity onset diabetes of the young_Homo sapiens_hsa049501.75674910
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.74099478
12Primary bile acid biosynthesis_Homo sapiens_hsa001201.74061612
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.64162953
14Nitrogen metabolism_Homo sapiens_hsa009101.64108203
15Butanoate metabolism_Homo sapiens_hsa006501.62593302
16Arginine biosynthesis_Homo sapiens_hsa002201.61986930
17GABAergic synapse_Homo sapiens_hsa047271.61721077
18Fatty acid degradation_Homo sapiens_hsa000711.58797338
19Pancreatic secretion_Homo sapiens_hsa049721.58643599
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.54147070
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.53748385
22Arginine and proline metabolism_Homo sapiens_hsa003301.52640153
23Long-term potentiation_Homo sapiens_hsa047201.51158486
24Insulin secretion_Homo sapiens_hsa049111.47744910
25* Glutamatergic synapse_Homo sapiens_hsa047241.46823398
26Dilated cardiomyopathy_Homo sapiens_hsa054141.44260264
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.42433189
28Taste transduction_Homo sapiens_hsa047421.42232315
29ABC transporters_Homo sapiens_hsa020101.39035719
30Salivary secretion_Homo sapiens_hsa049701.38623844
31Oxidative phosphorylation_Homo sapiens_hsa001901.38390210
32Amphetamine addiction_Homo sapiens_hsa050311.38238538
33Calcium signaling pathway_Homo sapiens_hsa040201.37427330
34Morphine addiction_Homo sapiens_hsa050321.37298306
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.34599433
36Synaptic vesicle cycle_Homo sapiens_hsa047211.34302968
37Dopaminergic synapse_Homo sapiens_hsa047281.33968708
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.32343759
39Alzheimers disease_Homo sapiens_hsa050101.30942739
40Fat digestion and absorption_Homo sapiens_hsa049751.25484296
41Parkinsons disease_Homo sapiens_hsa050121.22204504
42Fatty acid metabolism_Homo sapiens_hsa012121.20028018
43Aldosterone synthesis and secretion_Homo sapiens_hsa049251.19546519
44Gastric acid secretion_Homo sapiens_hsa049711.18979898
45beta-Alanine metabolism_Homo sapiens_hsa004101.18596026
46Cholinergic synapse_Homo sapiens_hsa047251.16593919
47Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.15824337
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.15704427
49Bile secretion_Homo sapiens_hsa049761.15291701
50Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.09849808
51Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.08916867
52Tryptophan metabolism_Homo sapiens_hsa003801.08680780
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.07892406
54Renin secretion_Homo sapiens_hsa049241.07880314
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.07411005
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.05501881
57Oxytocin signaling pathway_Homo sapiens_hsa049211.04506340
58Lysine degradation_Homo sapiens_hsa003101.02659021
59Pyruvate metabolism_Homo sapiens_hsa006201.02417929
60Serotonergic synapse_Homo sapiens_hsa047261.01927761
61Pentose and glucuronate interconversions_Homo sapiens_hsa000401.01790101
62Ovarian steroidogenesis_Homo sapiens_hsa049131.01558304
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00890057
64Insulin resistance_Homo sapiens_hsa049310.99013631
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.95426221
66Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.95251579
67Phenylalanine metabolism_Homo sapiens_hsa003600.94719247
68Cyanoamino acid metabolism_Homo sapiens_hsa004600.94639024
69Fatty acid biosynthesis_Homo sapiens_hsa000610.94466683
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.92395650
71cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91635276
72AMPK signaling pathway_Homo sapiens_hsa041520.91124781
73GnRH signaling pathway_Homo sapiens_hsa049120.89889809
74Starch and sucrose metabolism_Homo sapiens_hsa005000.85925130
75Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.84384173
76cAMP signaling pathway_Homo sapiens_hsa040240.84069109
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83249427
78Glucagon signaling pathway_Homo sapiens_hsa049220.81915625
79PPAR signaling pathway_Homo sapiens_hsa033200.79828275
80Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.78946773
81Huntingtons disease_Homo sapiens_hsa050160.75254787
82Melanogenesis_Homo sapiens_hsa049160.74895959
83Axon guidance_Homo sapiens_hsa043600.74476721
84Histidine metabolism_Homo sapiens_hsa003400.72546896
85Fatty acid elongation_Homo sapiens_hsa000620.72369117
86Phototransduction_Homo sapiens_hsa047440.71831294
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.71688050
88Peroxisome_Homo sapiens_hsa041460.70531767
89Glycerolipid metabolism_Homo sapiens_hsa005610.70482102
90Cysteine and methionine metabolism_Homo sapiens_hsa002700.70367266
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68894490
92Dorso-ventral axis formation_Homo sapiens_hsa043200.68546348
93Chemical carcinogenesis_Homo sapiens_hsa052040.67401222
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66969246
95Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.66856157
96Carbon metabolism_Homo sapiens_hsa012000.65832273
97Selenocompound metabolism_Homo sapiens_hsa004500.65771071
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65681340
99Long-term depression_Homo sapiens_hsa047300.63782671
100Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63646394
101Type II diabetes mellitus_Homo sapiens_hsa049300.63324825
102Retinol metabolism_Homo sapiens_hsa008300.62180985
103Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61306533
104Arachidonic acid metabolism_Homo sapiens_hsa005900.60838220
105Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59706216
106Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57876084
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.56280580
108Gap junction_Homo sapiens_hsa045400.55725304
109Tyrosine metabolism_Homo sapiens_hsa003500.54712116
110Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54666930
111Caffeine metabolism_Homo sapiens_hsa002320.54589707
112Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.52952152
113Steroid hormone biosynthesis_Homo sapiens_hsa001400.52635986
114Cocaine addiction_Homo sapiens_hsa050300.52503531
115Estrogen signaling pathway_Homo sapiens_hsa049150.51493745
116Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51492207
117Insulin signaling pathway_Homo sapiens_hsa049100.51096469
118Basal transcription factors_Homo sapiens_hsa030220.49173963
119Sulfur relay system_Homo sapiens_hsa041220.49065833
120Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47773870
121Complement and coagulation cascades_Homo sapiens_hsa046100.46654846
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.45192330
123ErbB signaling pathway_Homo sapiens_hsa040120.44294929
124Tight junction_Homo sapiens_hsa045300.43595242
125Sulfur metabolism_Homo sapiens_hsa009200.42556927
126Collecting duct acid secretion_Homo sapiens_hsa049660.42481334

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