HOGA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The authors of PMID:20797690 cloned this gene while searching for genes in a region of chromosome 10 linked to primary hyperoxalurea type III. They noted that even though the encoded protein has been described as a mitochondrial dihydrodipicolinate synthase-like enzyme, it shares little homology with E. coli dihydrodipicolinate synthase (Dhdps), particularly in the putative substrate-binding region. Moreover, neither lysine biosynthesis nor sialic acid metabolism, for which Dhdps is responsible, occurs in vertebrate mitochondria. They propose that this gene encodes mitochondrial 4-hydroxyl-2-oxoglutarate aldolase (EC 4.1.3.16), which catalyzes the final step in the metabolic pathway of hydroxyproline, releasing glyoxylate and pyruvate. This gene is predominantly expressed in the liver and kidney, and mutations in this gene are found in patients with primary hyperoxalurea type III. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.57589475
2L-phenylalanine catabolic process (GO:0006559)7.57589475
3L-phenylalanine metabolic process (GO:0006558)7.27387740
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.27387740
5aromatic amino acid family catabolic process (GO:0009074)6.87123189
6indole-containing compound catabolic process (GO:0042436)6.24493366
7indolalkylamine catabolic process (GO:0046218)6.24493366
8tryptophan catabolic process (GO:0006569)6.24493366
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.17210803
10kynurenine metabolic process (GO:0070189)6.04983032
11tryptophan metabolic process (GO:0006568)5.89267129
12bile acid biosynthetic process (GO:0006699)5.84687436
13behavioral response to nicotine (GO:0035095)5.67204920
14cysteine metabolic process (GO:0006534)5.63445947
15* glyoxylate metabolic process (GO:0046487)5.55895555
16urea metabolic process (GO:0019627)5.53313493
17urea cycle (GO:0000050)5.53313493
18negative regulation of fibrinolysis (GO:0051918)5.45400418
19alpha-linolenic acid metabolic process (GO:0036109)5.44793394
20high-density lipoprotein particle remodeling (GO:0034375)5.42150092
21sulfur amino acid catabolic process (GO:0000098)5.38208025
22serine family amino acid catabolic process (GO:0009071)5.26240954
23regulation of fibrinolysis (GO:0051917)5.23865348
24protein carboxylation (GO:0018214)5.19990837
25peptidyl-glutamic acid carboxylation (GO:0017187)5.19990837
26nitrogen cycle metabolic process (GO:0071941)5.09871047
27lysine catabolic process (GO:0006554)5.07554624
28lysine metabolic process (GO:0006553)5.07554624
29fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.04583722
30regulation of protein activation cascade (GO:2000257)5.02470820
31complement activation, alternative pathway (GO:0006957)5.00753703
32aromatic amino acid family metabolic process (GO:0009072)5.00635063
33bile acid metabolic process (GO:0008206)4.97375360
34homocysteine metabolic process (GO:0050667)4.95721684
35amino-acid betaine metabolic process (GO:0006577)4.78942143
36reverse cholesterol transport (GO:0043691)4.76921523
37tyrosine metabolic process (GO:0006570)4.76398829
38regulation of cholesterol esterification (GO:0010872)4.71805549
39regulation of triglyceride catabolic process (GO:0010896)4.69155694
40regulation of complement activation (GO:0030449)4.68167930
41* alpha-amino acid catabolic process (GO:1901606)4.66224996
42plasma lipoprotein particle remodeling (GO:0034369)4.64599067
43protein-lipid complex remodeling (GO:0034368)4.64599067
44macromolecular complex remodeling (GO:0034367)4.64599067
45cellular ketone body metabolic process (GO:0046950)4.63228474
46negative regulation of sterol transport (GO:0032372)4.52277357
47negative regulation of cholesterol transport (GO:0032375)4.52277357
48acylglycerol homeostasis (GO:0055090)4.52222760
49triglyceride homeostasis (GO:0070328)4.52222760
50indolalkylamine metabolic process (GO:0006586)4.43341514
51phospholipid efflux (GO:0033700)4.42624521
52glycine metabolic process (GO:0006544)4.38947098
53glutamate metabolic process (GO:0006536)4.36501602
54serine family amino acid metabolic process (GO:0009069)4.35525969
55* cellular amino acid catabolic process (GO:0009063)4.33011200
56water-soluble vitamin biosynthetic process (GO:0042364)4.31421150
57amine catabolic process (GO:0009310)4.31203915
58cellular biogenic amine catabolic process (GO:0042402)4.31203915
59plasma lipoprotein particle clearance (GO:0034381)4.30253819
60coenzyme catabolic process (GO:0009109)4.27478893
61drug catabolic process (GO:0042737)4.26327583
62cellular glucuronidation (GO:0052695)4.23550401
63bile acid and bile salt transport (GO:0015721)4.20953904
64imidazole-containing compound metabolic process (GO:0052803)4.20017431
65benzene-containing compound metabolic process (GO:0042537)4.15984245
66serine family amino acid biosynthetic process (GO:0009070)4.14968061
67cholesterol efflux (GO:0033344)4.06779272
68ethanol oxidation (GO:0006069)4.05779381
69dicarboxylic acid biosynthetic process (GO:0043650)4.04897738
70urate metabolic process (GO:0046415)4.01433475
71ketone body metabolic process (GO:1902224)4.01240346
72arginine metabolic process (GO:0006525)4.00664769
73short-chain fatty acid metabolic process (GO:0046459)3.94210218
74drug transmembrane transport (GO:0006855)3.93335532
75fibrinolysis (GO:0042730)3.90391015
76S-adenosylmethionine metabolic process (GO:0046500)3.88730709
77* cellular modified amino acid catabolic process (GO:0042219)3.87934228
78plasma lipoprotein particle assembly (GO:0034377)3.86847672
79low-density lipoprotein particle remodeling (GO:0034374)3.84316259
80fucose catabolic process (GO:0019317)3.82261581
81L-fucose metabolic process (GO:0042354)3.82261581
82L-fucose catabolic process (GO:0042355)3.82261581
83* carboxylic acid catabolic process (GO:0046395)3.81417956
84* organic acid catabolic process (GO:0016054)3.81417956
85uronic acid metabolic process (GO:0006063)3.81024523
86glucuronate metabolic process (GO:0019585)3.81024523
87acetyl-CoA metabolic process (GO:0006084)3.78618311
88positive regulation of lipoprotein lipase activity (GO:0051006)3.75449663
89positive regulation of triglyceride lipase activity (GO:0061365)3.75449663
90oxidative demethylation (GO:0070989)3.74953469
91aspartate family amino acid catabolic process (GO:0009068)3.74377303
92exogenous drug catabolic process (GO:0042738)3.73382981
93phospholipid homeostasis (GO:0055091)3.69699471
94cholesterol homeostasis (GO:0042632)3.69304480
95blood coagulation, intrinsic pathway (GO:0007597)3.68942708
96regulation of bile acid biosynthetic process (GO:0070857)3.68743347
97epoxygenase P450 pathway (GO:0019373)3.68295799
98cofactor catabolic process (GO:0051187)3.67352258
99omega-hydroxylase P450 pathway (GO:0097267)3.66866354
100positive regulation of lipid catabolic process (GO:0050996)3.66693213
101regulation of cholesterol homeostasis (GO:2000188)3.65116926
102sterol homeostasis (GO:0055092)3.64661751
1032-oxoglutarate metabolic process (GO:0006103)3.61937549
104indole-containing compound metabolic process (GO:0042430)3.60183091
105negative regulation of lipase activity (GO:0060192)3.59697787
106detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.59369291
107carnitine metabolic process (GO:0009437)3.54495105
108NAD biosynthetic process (GO:0009435)3.53540201
109fatty acid oxidation (GO:0019395)3.53398884
110very-low-density lipoprotein particle assembly (GO:0034379)3.53030289
111fatty acid beta-oxidation (GO:0006635)3.52642768
112L-methionine salvage (GO:0071267)3.36680397
113L-methionine biosynthetic process (GO:0071265)3.36680397
114amino acid salvage (GO:0043102)3.36680397
115sulfation (GO:0051923)3.25204368
116drug metabolic process (GO:0017144)3.24157563
117mannosylation (GO:0097502)3.17661599
118detection of light stimulus involved in visual perception (GO:0050908)3.09263864
119detection of light stimulus involved in sensory perception (GO:0050962)3.09263864
120DNA deamination (GO:0045006)3.04993583
121platelet dense granule organization (GO:0060155)2.96577844
122epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.95941492
123alkaloid metabolic process (GO:0009820)2.95338695
124response to pheromone (GO:0019236)2.94609722
125dopamine transport (GO:0015872)2.89397119
126protein complex biogenesis (GO:0070271)2.89241867
127primary amino compound metabolic process (GO:1901160)2.87559463
128regulation of cilium movement (GO:0003352)2.87211207
129pyrimidine nucleobase catabolic process (GO:0006208)2.84030185
130ubiquinone biosynthetic process (GO:0006744)2.81619218
131mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.79616070
132mitochondrial respiratory chain complex I assembly (GO:0032981)2.79616070
133NADH dehydrogenase complex assembly (GO:0010257)2.79616070
134negative regulation of mast cell activation (GO:0033004)2.79542963
135gamma-aminobutyric acid transport (GO:0015812)2.77063249
136L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.76484918
137arginine catabolic process (GO:0006527)2.74101302
138mitochondrial respiratory chain complex assembly (GO:0033108)2.68039857
139negative regulation of cytosolic calcium ion concentration (GO:0051481)2.67506233
140preassembly of GPI anchor in ER membrane (GO:0016254)2.67036953
141quinone biosynthetic process (GO:1901663)2.66683811
142serotonin metabolic process (GO:0042428)2.65381290
143respiratory chain complex IV assembly (GO:0008535)2.64013052
144vitamin biosynthetic process (GO:0009110)2.63604150
145synaptic transmission, cholinergic (GO:0007271)2.62163130
146regulation of action potential (GO:0098900)2.61393662
147positive regulation of fatty acid transport (GO:2000193)2.60641609
148glycerophospholipid catabolic process (GO:0046475)2.58225301
149axoneme assembly (GO:0035082)2.57842935
150epithelial cilium movement (GO:0003351)2.57322204
151nucleobase catabolic process (GO:0046113)2.56513941
152methionine biosynthetic process (GO:0009086)2.55602875
153ubiquinone metabolic process (GO:0006743)2.54876622
154piRNA metabolic process (GO:0034587)2.54542748
155organic cation transport (GO:0015695)2.52297275
156cytochrome complex assembly (GO:0017004)2.52180268
1573-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.49183421
158purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.49183421
159regulation of hexokinase activity (GO:1903299)2.48494668
160regulation of glucokinase activity (GO:0033131)2.48494668
161protein neddylation (GO:0045116)2.46035775
162negative regulation of reactive oxygen species metabolic process (GO:2000378)2.45337613
163energy coupled proton transport, down electrochemical gradient (GO:0015985)2.44873440
164ATP synthesis coupled proton transport (GO:0015986)2.44873440
165polyol catabolic process (GO:0046174)2.42481057
166photoreceptor cell development (GO:0042461)2.42129377
167negative regulation of synaptic transmission, GABAergic (GO:0032229)2.41565811
168mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.41466663
169cAMP catabolic process (GO:0006198)2.40957464
170reflex (GO:0060004)2.38515550

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.34614831
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.15637859
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.82944611
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.45581411
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.17010183
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.94148565
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.91655970
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.98120438
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.91100343
10ZNF274_21170338_ChIP-Seq_K562_Hela3.62019162
11VDR_22108803_ChIP-Seq_LS180_Human3.02269763
12GBX2_23144817_ChIP-Seq_PC3_Human2.74791077
13EZH2_22144423_ChIP-Seq_EOC_Human2.41833160
14IGF1R_20145208_ChIP-Seq_DFB_Human2.32546174
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.28562592
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.22006868
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.13975157
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.13585908
19HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.09996372
20TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.08730302
21TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.07791195
22ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.8497608
23CTBP2_25329375_ChIP-Seq_LNCAP_Human1.92293817
24CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87585968
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.87267874
26RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83626770
27P300_19829295_ChIP-Seq_ESCs_Human1.81619936
28FUS_26573619_Chip-Seq_HEK293_Human1.75772563
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.73455104
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72465233
31ER_23166858_ChIP-Seq_MCF-7_Human1.64017135
32IRF1_19129219_ChIP-ChIP_H3396_Human1.62778890
33FOXA2_19822575_ChIP-Seq_HepG2_Human1.62444310
34CLOCK_20551151_ChIP-Seq_293T_Human1.56898893
35EWS_26573619_Chip-Seq_HEK293_Human1.54274087
36HNF4A_19822575_ChIP-Seq_HepG2_Human1.44695597
37MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.43936246
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.43733494
39CBP_20019798_ChIP-Seq_JUKART_Human1.43529398
40IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43529398
41HTT_18923047_ChIP-ChIP_STHdh_Human1.43423213
42FOXA1_27270436_Chip-Seq_PROSTATE_Human1.42908267
43FOXA1_25329375_ChIP-Seq_VCAP_Human1.42908267
44AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42174758
45TP53_22573176_ChIP-Seq_HFKS_Human1.41574467
46PCGF2_27294783_Chip-Seq_NPCs_Mouse1.41079047
47STAT3_23295773_ChIP-Seq_U87_Human1.39867128
48REST_21632747_ChIP-Seq_MESCs_Mouse1.39842089
49UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39754219
50GATA3_21878914_ChIP-Seq_MCF-7_Human1.38484791
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37726640
52GATA1_22025678_ChIP-Seq_K562_Human1.37368111
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.37348704
54NFE2_27457419_Chip-Seq_LIVER_Mouse1.37311308
55ETV2_25802403_ChIP-Seq_MESCs_Mouse1.36918914
56TCF4_23295773_ChIP-Seq_U87_Human1.35423340
57NR3C1_21868756_ChIP-Seq_MCF10A_Human1.34113786
58SMAD4_21799915_ChIP-Seq_A2780_Human1.32341885
59TCF4_22108803_ChIP-Seq_LS180_Human1.30983981
60AR_25329375_ChIP-Seq_VCAP_Human1.30864127
61GABP_17652178_ChIP-ChIP_JURKAT_Human1.30784600
62MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29008293
63BMI1_23680149_ChIP-Seq_NPCS_Mouse1.28803929
64CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28536891
65EZH2_27294783_Chip-Seq_NPCs_Mouse1.27497385
66SOX2_19829295_ChIP-Seq_ESCs_Human1.27326831
67NANOG_19829295_ChIP-Seq_ESCs_Human1.27326831
68NCOR_22424771_ChIP-Seq_293T_Human1.26954955
69MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26769176
70NOTCH1_21737748_ChIP-Seq_TLL_Human1.26111748
71SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26084329
72GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24784568
73STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.24515872
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22929924
75POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22358302
76TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22358302
77THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.21629293
78CBX2_27304074_Chip-Seq_ESCs_Mouse1.20559389
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19999654
80RXRA_24833708_ChIP-Seq_LIVER_Mouse1.19077206
81MYC_18940864_ChIP-ChIP_HL60_Human1.18970170
82KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18586558
83FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11233751
84CRX_20693478_ChIP-Seq_RETINA_Mouse1.11169048
85SMAD3_21741376_ChIP-Seq_EPCs_Human1.10311639
86SMAD4_21741376_ChIP-Seq_EPCs_Human1.09830786
87MYC_19829295_ChIP-Seq_ESCs_Human1.07446328
88TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.06733184
89KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.06622148
90RUNX2_22187159_ChIP-Seq_PCA_Human1.06556041
91EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06249870
92IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.05828360
93ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05180062
94EST1_17652178_ChIP-ChIP_JURKAT_Human1.05001355
95HOXB7_26014856_ChIP-Seq_BT474_Human1.04592251
96RNF2_27304074_Chip-Seq_NSC_Mouse1.04146193
97FOXH1_21741376_ChIP-Seq_EPCs_Human1.04053204
98NANOG_18555785_Chip-Seq_ESCs_Mouse1.03885272
99CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.03459513
100P53_22387025_ChIP-Seq_ESCs_Mouse1.03402177
101SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03313099
102REST_18959480_ChIP-ChIP_MESCs_Mouse1.02385809
103SALL1_21062744_ChIP-ChIP_HESCs_Human1.02311744
104STAT3_18555785_Chip-Seq_ESCs_Mouse1.02172218
105TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01928149
106ERA_21632823_ChIP-Seq_H3396_Human1.01855523
107STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.01273908
108HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.00485172
109RARG_19884340_ChIP-ChIP_MEFs_Mouse0.99572417
110PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99472170
111CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.98742580
112SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.98155870
113ESR1_15608294_ChIP-ChIP_MCF-7_Human0.97854971
114SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96824558
115PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.91202645
116GATA4_25053715_ChIP-Seq_YYC3_Human0.88706167
117ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.88557534
118ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.84145453
119IRF8_22096565_ChIP-ChIP_GC-B_Human0.82685799
120AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82132239
121KAP1_22055183_ChIP-Seq_ESCs_Mouse0.77958302
122BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.76028623
123SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.75708721
124ESR2_21235772_ChIP-Seq_MCF-7_Human0.75513781
125Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.73632825
126SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.73355189
127CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.72889799
128RARA_24833708_ChIP-Seq_LIVER_Mouse0.72607938
129AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.69264321
130SALL4_18804426_ChIP-ChIP_XEN_Mouse0.69214284
131RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.68323430
132NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.66949199
133ESR1_21235772_ChIP-Seq_MCF-7_Human0.66773156
134ZNF263_19887448_ChIP-Seq_K562_Human0.66740721
135BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.65182846
136RAD21_21589869_ChIP-Seq_MESCs_Mouse0.65056017
137NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.64871824
138NRF2_20460467_ChIP-Seq_MEFs_Mouse0.64871824
139NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.63394412
140RARB_24833708_ChIP-Seq_LIVER_Mouse0.61394418
141EGR1_19032775_ChIP-ChIP_M12_Human0.59680152
142CEBPB_22108803_ChIP-Seq_LS180_Human0.59514309
143LXR_22292898_ChIP-Seq_THP-1_Human0.58503865
144STAT3_1855785_ChIP-Seq_MESCs_Mouse0.56819261
145AR_20517297_ChIP-Seq_VCAP_Human0.55047726
146MYC_19915707_ChIP-ChIP_AK7_Human0.54747163
147CDX2_20551321_ChIP-Seq_CACO-2_Human0.53992380
148FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.53166376
149PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.52895873
150FOXA1_25552417_ChIP-Seq_VCAP_Human0.52326672
151STAT1_17558387_ChIP-Seq_HELA_Human0.50990105
152ESET_19884257_ChIP-Seq_ESCs_Mouse0.50704692
153CBP_21632823_ChIP-Seq_H3396_Human0.50505888
154PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.47839291
155FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.47538787
156FOXO3_23340844_ChIP-Seq_DLD1_Human0.47369028
157P53_21459846_ChIP-Seq_SAOS-2_Human0.46379894
158PPAR_26484153_Chip-Seq_NCI-H1993_Human0.45259782
159TAF2_19829295_ChIP-Seq_ESCs_Human0.44979162
160GATA6_25053715_ChIP-Seq_YYC3_Human0.44785237
161PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.44740418
162FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.43698367
163NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.43039867
164GATA1_19941827_ChIP-Seq_MEL_Mouse0.42910351
165GATA1_19941826_ChIP-Seq_K562_Human0.42884673
166PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.42563987
167GATA2_19941826_ChIP-Seq_K562_Human0.42230241
168FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.42090644
169GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.41749151
170SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.41138556
171CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.39404918
172ERG_21242973_ChIP-ChIP_JURKAT_Human0.39384049
173ESR1_20079471_ChIP-ChIP_T-47D_Human0.38747535
174STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.38660132
175E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.38427555
176MYC_27129775_Chip-Seq_CORNEA_Mouse0.37941511
177CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.37880620
178CDX2_22108803_ChIP-Seq_LS180_Human0.37853704
179BCAT_22108803_ChIP-Seq_LS180_Human0.37619171
180LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.36367782
181SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.36054303
182TAF15_26573619_Chip-Seq_HEK293_Human0.35957522
183EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.35924771
184P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.35810446
185SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.35709092

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.20846156
2MP0005360_urolithiasis7.79451611
3MP0005085_abnormal_gallbladder_physiolo6.24285165
4MP0005365_abnormal_bile_salt6.01903260
5MP0008875_abnormal_xenobiotic_pharmacok5.04511651
6MP0003806_abnormal_nucleotide_metabolis4.15580123
7MP0003252_abnormal_bile_duct3.91069789
8MP0010329_abnormal_lipoprotein_level3.48051136
9MP0009840_abnormal_foam_cell3.11804530
10MP0003195_calcinosis3.06707822
11MP0005332_abnormal_amino_acid3.06028778
12MP0005083_abnormal_biliary_tract2.93378433
13MP0001666_abnormal_nutrient_absorption2.52723087
14MP0004019_abnormal_vitamin_homeostasis2.48164219
15MP0005551_abnormal_eye_electrophysiolog2.41982421
16MP0003191_abnormal_cellular_cholesterol2.32224999
17MP0003646_muscle_fatigue2.27047831
18MP0002138_abnormal_hepatobiliary_system2.21009378
19MP0002638_abnormal_pupillary_reflex2.10928318
20MP0000609_abnormal_liver_physiology2.10321618
21MP0002102_abnormal_ear_morphology2.09678860
22MP0002118_abnormal_lipid_homeostasis2.06509386
23MP0005646_abnormal_pituitary_gland1.98655588
24MP0005319_abnormal_enzyme/_coenzyme1.84434451
25MP0006292_abnormal_olfactory_placode1.84284739
26MP0001968_abnormal_touch/_nociception1.81766023
27MP0003868_abnormal_feces_composition1.78018114
28MP0008877_abnormal_DNA_methylation1.76721571
29MP0001986_abnormal_taste_sensitivity1.76042643
30MP0006072_abnormal_retinal_apoptosis1.71441882
31MP0001764_abnormal_homeostasis1.69987849
32MP0009745_abnormal_behavioral_response1.69462717
33MP0001501_abnormal_sleep_pattern1.64526496
34MP0003136_yellow_coat_color1.63671275
35MP0005584_abnormal_enzyme/coenzyme_acti1.62389125
36MP0004885_abnormal_endolymph1.59848752
37MP0009046_muscle_twitch1.56874725
38MP0002736_abnormal_nociception_after1.56652294
39MP0005253_abnormal_eye_physiology1.53090063
40MP0005451_abnormal_body_composition1.52196740
41MP0009643_abnormal_urine_homeostasis1.51936058
42MP0010386_abnormal_urinary_bladder1.49586630
43MP0005645_abnormal_hypothalamus_physiol1.48477126
44MP0000569_abnormal_digit_pigmentation1.47198752
45MP0009697_abnormal_copulation1.46313446
46MP0002234_abnormal_pharynx_morphology1.43299578
47MP0001485_abnormal_pinna_reflex1.39783329
48MP0008775_abnormal_heart_ventricle1.38881384
49MP0002272_abnormal_nervous_system1.37760450
50MP0002160_abnormal_reproductive_system1.36413953
51MP0003186_abnormal_redox_activity1.35966578
52MP0001984_abnormal_olfaction1.33144686
53MP0003011_delayed_dark_adaptation1.32178079
54MP0001486_abnormal_startle_reflex1.29467728
55MP0003787_abnormal_imprinting1.28898759
56MP0000372_irregular_coat_pigmentation1.28241343
57MP0006276_abnormal_autonomic_nervous1.25832508
58MP0005389_reproductive_system_phenotype1.25326055
59MP0002909_abnormal_adrenal_gland1.24667321
60MP0005379_endocrine/exocrine_gland_phen1.23160273
61MP0002163_abnormal_gland_morphology1.22635412
62MP0004215_abnormal_myocardial_fiber1.22148811
63MP0000631_abnormal_neuroendocrine_gland1.20252863
64MP0003656_abnormal_erythrocyte_physiolo1.19534442
65MP0004133_heterotaxia1.17078567
66MP0004145_abnormal_muscle_electrophysio1.16994688
67MP0000427_abnormal_hair_cycle1.16540591
68MP0000598_abnormal_liver_morphology1.16335346
69MP0002557_abnormal_social/conspecific_i1.15525639
70MP0005636_abnormal_mineral_homeostasis1.14563773
71MP0002572_abnormal_emotion/affect_behav1.13126754
72MP0004142_abnormal_muscle_tone1.13126151
73MP0005386_behavior/neurological_phenoty1.12945908
74MP0004924_abnormal_behavior1.12945908
75MP0003705_abnormal_hypodermis_morpholog1.11078527
76MP0002064_seizures1.08034715
77MP0005647_abnormal_sex_gland1.07095345
78MP0002653_abnormal_ependyma_morphology1.06794763
79MP0009764_decreased_sensitivity_to1.05867976
80MP0000604_amyloidosis1.03666123
81MP0002735_abnormal_chemical_nociception1.02979887
82MP0005195_abnormal_posterior_eye0.99205638
83MP0003880_abnormal_central_pattern0.98653931
84MP0001919_abnormal_reproductive_system0.98284041
85MP0001970_abnormal_pain_threshold0.97533437
86MP0009763_increased_sensitivity_to0.95982371
87MP0002254_reproductive_system_inflammat0.95690860
88MP0002938_white_spotting0.94164293
89MP0004742_abnormal_vestibular_system0.93897620
90MP0002733_abnormal_thermal_nociception0.89881761
91MP0010368_abnormal_lymphatic_system0.89429807
92MP0009642_abnormal_blood_homeostasis0.88887291
93MP0006036_abnormal_mitochondrial_physio0.88706406
94MP0008469_abnormal_protein_level0.88604613
95MP0005084_abnormal_gallbladder_morpholo0.88351690
96MP0001905_abnormal_dopamine_level0.87251411
97MP0002876_abnormal_thyroid_physiology0.85973876
98MP0003137_abnormal_impulse_conducting0.85145804
99MP0005408_hypopigmentation0.84749470
100MP0001502_abnormal_circadian_rhythm0.84528232
101MP0001756_abnormal_urination0.84033633
102MP0004147_increased_porphyrin_level0.84000235
103MP0005670_abnormal_white_adipose0.83619723
104MP0005377_hearing/vestibular/ear_phenot0.83572135
105MP0003878_abnormal_ear_physiology0.83572135
106MP0005167_abnormal_blood-brain_barrier0.80879972
107MP0000026_abnormal_inner_ear0.79422014
108MP0002063_abnormal_learning/memory/cond0.78103420
109MP0005376_homeostasis/metabolism_phenot0.77855216
110MP0001440_abnormal_grooming_behavior0.77854261
111MP0002078_abnormal_glucose_homeostasis0.77183964
112MP0005410_abnormal_fertilization0.77124047
113MP0005174_abnormal_tail_pigmentation0.76166290
114MP0001944_abnormal_pancreas_morphology0.76073142
115MP0001324_abnormal_eye_pigmentation0.75108497
116MP0009765_abnormal_xenobiotic_induced0.74846773
117MP0003635_abnormal_synaptic_transmissio0.74594123
118MP0005220_abnormal_exocrine_pancreas0.73768721
119MP0005535_abnormal_body_temperature0.71641816
120MP0002971_abnormal_brown_adipose0.70147575
121MP0002136_abnormal_kidney_physiology0.69471698
122MP0001661_extended_life_span0.69358349
123MP0005334_abnormal_fat_pad0.66187120
124MP0004043_abnormal_pH_regulation0.65713344
125MP0004130_abnormal_muscle_cell0.65638801
126MP0003690_abnormal_glial_cell0.61805599
127MP0009053_abnormal_anal_canal0.61624329
128MP0005266_abnormal_metabolism0.61120700
129MP0003329_amyloid_beta_deposits0.61099238
130MP0006035_abnormal_mitochondrial_morpho0.57724794
131MP0002928_abnormal_bile_duct0.55590051
132MP0000639_abnormal_adrenal_gland0.53317694
133MP0005395_other_phenotype0.52187837
134MP0003638_abnormal_response/metabolism_0.49863355
135MP0005448_abnormal_energy_balance0.49392243
136MP0005464_abnormal_platelet_physiology0.47019358
137MP0001765_abnormal_ion_homeostasis0.45676099
138MP0005666_abnormal_adipose_tissue0.43909759
139MP0003718_maternal_effect0.43066603
140MP0008874_decreased_physiological_sensi0.42545967
141MP0003953_abnormal_hormone_level0.41777737
142MP0004782_abnormal_surfactant_physiolog0.41459739
143MP0003724_increased_susceptibility_to0.41260502
144MP0008873_increased_physiological_sensi0.41193267
145MP0002168_other_aberrant_phenotype0.40000015
146MP0003075_altered_response_to0.39516347
147MP0000230_abnormal_systemic_arterial0.39498320
148MP0002796_impaired_skin_barrier0.39251409
149MP0009672_abnormal_birth_weight0.38006191
150MP0005058_abnormal_lysosome_morphology0.37648213
151MP0002822_catalepsy0.37517767
152MP0005166_decreased_susceptibility_to0.37363461
153MP0008872_abnormal_physiological_respon0.36204882
154MP0003436_decreased_susceptibility_to0.36189791
155MP0002837_dystrophic_cardiac_calcinosis0.35660301
156MP0005248_abnormal_Harderian_gland0.33402894
157MP0009115_abnormal_fat_cell0.32417075
158MP0002135_abnormal_kidney_morphology0.31339615
159MP0006082_CNS_inflammation0.29687038
160MP0000249_abnormal_blood_vessel0.29434833
161MP0001845_abnormal_inflammatory_respons0.28642735
162MP0009384_cardiac_valve_regurgitation0.28303579
163MP0000579_abnormal_nail_morphology0.28067474
164MP0001881_abnormal_mammary_gland0.27496271
165MP0004883_abnormal_blood_vessel0.27449168
166MP0002970_abnormal_white_adipose0.27284426
167MP0001243_abnormal_dermal_layer0.27226197
168MP0000538_abnormal_urinary_bladder0.26445290
169MP0004381_abnormal_hair_follicle0.26378860

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.26729498
2Deep venous thrombosis (HP:0002625)7.06646917
3Intrahepatic cholestasis (HP:0001406)6.97229912
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.39611416
5Prolonged partial thromboplastin time (HP:0003645)6.17840995
6Xanthomatosis (HP:0000991)6.14543001
7Hypobetalipoproteinemia (HP:0003563)6.00337853
8Hyperlipoproteinemia (HP:0010980)5.25775394
9Complement deficiency (HP:0004431)4.93805223
10Hyperammonemia (HP:0001987)4.68449098
11Joint hemorrhage (HP:0005261)4.66243613
12Abnormality of glutamine family amino acid metabolism (HP:0010902)4.56783625
13Hypolipoproteinemia (HP:0010981)4.55093533
14Hyperglycinemia (HP:0002154)4.54325513
15Ketosis (HP:0001946)4.46188254
16Hyperglycinuria (HP:0003108)4.36637294
17Abnormality of sulfur amino acid metabolism (HP:0004339)4.30732181
18Abnormality of aspartate family amino acid metabolism (HP:0010899)4.28585557
19Abnormality of glycine metabolism (HP:0010895)4.23939630
20Abnormality of serine family amino acid metabolism (HP:0010894)4.23939630
21Epidermoid cyst (HP:0200040)4.23101757
22Abnormality of the common coagulation pathway (HP:0010990)4.21045347
23Pancreatic cysts (HP:0001737)4.20071270
24Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.15509082
25Abnormality of methionine metabolism (HP:0010901)4.12098673
26Hypoalphalipoproteinemia (HP:0003233)4.03516079
27Fat malabsorption (HP:0002630)3.92992740
28Congenital stationary night blindness (HP:0007642)3.92160396
29Hypoglycemic coma (HP:0001325)3.84588446
30Abnormality of pyrimidine metabolism (HP:0004353)3.79316854
31Type II lissencephaly (HP:0007260)3.75671247
32Pancreatic fibrosis (HP:0100732)3.73050432
33True hermaphroditism (HP:0010459)3.66995295
34Abnormality of the renal cortex (HP:0011035)3.62438124
35Abnormality of complement system (HP:0005339)3.57358126
36Abnormality of the intrinsic pathway (HP:0010989)3.57217223
37Abnormality of fatty-acid metabolism (HP:0004359)3.56870344
38Conjugated hyperbilirubinemia (HP:0002908)3.53112419
39Hypercholesterolemia (HP:0003124)3.42261303
40Abnormality of nucleobase metabolism (HP:0010932)3.34494108
41Ketoacidosis (HP:0001993)3.33418333
42Molar tooth sign on MRI (HP:0002419)3.32760958
43Abnormality of midbrain morphology (HP:0002418)3.32760958
44Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.30940646
45Delayed CNS myelination (HP:0002188)3.29322928
46Hyperbilirubinemia (HP:0002904)3.26089133
47Gout (HP:0001997)3.20945360
48Nephronophthisis (HP:0000090)3.16958464
49Abnormality of serum amino acid levels (HP:0003112)3.16622460
50Abnormality of purine metabolism (HP:0004352)3.12082734
51Hyperventilation (HP:0002883)3.09140025
52Hepatocellular carcinoma (HP:0001402)3.01651682
53Polydipsia (HP:0001959)2.96589070
54Abnormal drinking behavior (HP:0030082)2.96589070
55Abnormality of the renal medulla (HP:0100957)2.95557368
56Steatorrhea (HP:0002570)2.94452931
57Metabolic acidosis (HP:0001942)2.94102625
58Vascular calcification (HP:0004934)2.85538067
59Spontaneous abortion (HP:0005268)2.82367106
60Attenuation of retinal blood vessels (HP:0007843)2.81374648
61Medial flaring of the eyebrow (HP:0010747)2.80003910
62Myocardial infarction (HP:0001658)2.78720641
63Dicarboxylic aciduria (HP:0003215)2.78584049
64Abnormality of dicarboxylic acid metabolism (HP:0010995)2.78584049
65Hypochromic microcytic anemia (HP:0004840)2.74807461
66Chronic hepatic failure (HP:0100626)2.73771612
67Lethargy (HP:0001254)2.72717731
68Hypothermia (HP:0002045)2.72603989
69Tubular atrophy (HP:0000092)2.68242321
70Cystic liver disease (HP:0006706)2.65998836
71Polyuria (HP:0000103)2.62263178
72Decreased central vision (HP:0007663)2.58831225
73Systemic lupus erythematosus (HP:0002725)2.57899600
74Skin nodule (HP:0200036)2.57643685
75Cerebellar dysplasia (HP:0007033)2.55445314
76Cardiovascular calcification (HP:0011915)2.53611665
77Spastic diplegia (HP:0001264)2.50955887
78Generalized aminoaciduria (HP:0002909)2.48838641
79Abnormality of alanine metabolism (HP:0010916)2.47677654
80Hyperalaninemia (HP:0003348)2.47677654
81Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.47677654
82Hypomagnesemia (HP:0002917)2.47022743
83Abolished electroretinogram (ERG) (HP:0000550)2.46797600
84Cerebral edema (HP:0002181)2.46229405
85Abnormal rod and cone electroretinograms (HP:0008323)2.44437438
86Malnutrition (HP:0004395)2.42797776
87Irritability (HP:0000737)2.42347885
88Neonatal onset (HP:0003623)2.41502376
89Pendular nystagmus (HP:0012043)2.41362016
90Hypoglycemic seizures (HP:0002173)2.37904324
91Decreased electroretinogram (ERG) amplitude (HP:0000654)2.35675048
92Mitral stenosis (HP:0001718)2.35398128
93Acanthocytosis (HP:0001927)2.34403337
94Enlarged kidneys (HP:0000105)2.33228063
95Alkalosis (HP:0001948)2.33224670
96Large for gestational age (HP:0001520)2.33065475
973-Methylglutaconic aciduria (HP:0003535)2.32655573
98Proximal tubulopathy (HP:0000114)2.30997411
99Acute encephalopathy (HP:0006846)2.30986807
100Fair hair (HP:0002286)2.30666092
101Glomerulonephritis (HP:0000099)2.30497040
102Abnormal gallbladder morphology (HP:0012437)2.29533941
103Abnormal urine output (HP:0012590)2.28400799
104Mitochondrial inheritance (HP:0001427)2.27204789
105Severe muscular hypotonia (HP:0006829)2.27133269
106Vomiting (HP:0002013)2.26270493
107Cholelithiasis (HP:0001081)2.25201675
108Abnormal biliary tract physiology (HP:0012439)2.24044507
109Bile duct proliferation (HP:0001408)2.24044507
110Hyperuricemia (HP:0002149)2.23983981
111Increased purine levels (HP:0004368)2.23983981
112Sensorimotor neuropathy (HP:0007141)2.21117797
113Hydroxyprolinuria (HP:0003080)2.20612781
114Abnormality of proline metabolism (HP:0010907)2.20612781
115Gait imbalance (HP:0002141)2.20257624
116Abnormal gallbladder physiology (HP:0012438)2.19905892
117Cholecystitis (HP:0001082)2.19905892
118Pancreatitis (HP:0001733)2.18987412
119Acute necrotizing encephalopathy (HP:0006965)2.18130699
120Lissencephaly (HP:0001339)2.17495825
121Amyloidosis (HP:0011034)2.16926944
122Increased CSF lactate (HP:0002490)2.15993364
123Rickets (HP:0002748)2.15766820
124Methylmalonic aciduria (HP:0012120)2.15307031
125Congenital primary aphakia (HP:0007707)2.14891092
126Nephrogenic diabetes insipidus (HP:0009806)2.14753128
127Esophageal varix (HP:0002040)2.14450579
128Recurrent gram-negative bacterial infections (HP:0005420)2.13304634
129Increased corneal curvature (HP:0100692)2.13252759
130Keratoconus (HP:0000563)2.13252759
131Late onset (HP:0003584)2.13033451
132Stomach cancer (HP:0012126)2.12436711
133Hepatic necrosis (HP:0002605)2.10319170
134Menorrhagia (HP:0000132)2.07451083
135Sclerocornea (HP:0000647)2.06951209
136Congenital, generalized hypertrichosis (HP:0004540)2.06737026
137Abnormality of renal excretion (HP:0011036)2.05492663
138Gingival bleeding (HP:0000225)2.04291530
139Brushfield spots (HP:0001088)2.04159263
140Opisthotonus (HP:0002179)2.03832525
141Thrombophlebitis (HP:0004418)2.03516023
142Progressive macrocephaly (HP:0004481)2.01774753
143Glycosuria (HP:0003076)2.00482823
144Abnormality of urine glucose concentration (HP:0011016)2.00482823
145Furrowed tongue (HP:0000221)1.99254047
146Chorioretinal atrophy (HP:0000533)1.99032972
147Hypophosphatemic rickets (HP:0004912)1.97387493
148Abnormal enzyme/coenzyme activity (HP:0012379)1.97170235
149Methylmalonic acidemia (HP:0002912)1.96673871
150Decreased circulating renin level (HP:0003351)1.96468920
151Gaze-evoked nystagmus (HP:0000640)1.95640984
152Hepatocellular necrosis (HP:0001404)1.95049890
153Hemorrhage of the eye (HP:0011885)1.94826416
154Optic disc pallor (HP:0000543)1.94509877
155Aplasia/hypoplasia of the uterus (HP:0008684)1.92236819
156Metabolic alkalosis (HP:0200114)1.92196883
157Absent rod-and cone-mediated responses on ERG (HP:0007688)1.91504052
158Hyperinsulinemic hypoglycemia (HP:0000825)1.91353234
159Abnormality of the gallbladder (HP:0005264)1.90562796
160Male pseudohermaphroditism (HP:0000037)1.90250095
161Abnormal cartilage morphology (HP:0002763)1.90156362
162Renal cortical cysts (HP:0000803)1.89709877
163Pachygyria (HP:0001302)1.89014091
164Absent/shortened dynein arms (HP:0200106)1.88445372
165Dynein arm defect of respiratory motile cilia (HP:0012255)1.88445372
166Genital tract atresia (HP:0001827)1.88261600
167Congenital hepatic fibrosis (HP:0002612)1.87551250
168Lipid accumulation in hepatocytes (HP:0006561)1.86823755
169Poikilocytosis (HP:0004447)1.86134113
170Aplasia/Hypoplasia of the tongue (HP:0010295)1.85958559
171Febrile seizures (HP:0002373)1.85408705
172Inability to walk (HP:0002540)1.85110020
173Aplasia/Hypoplasia of the tibia (HP:0005772)1.84068873
174Vaginal atresia (HP:0000148)1.83120300
175Abnormality of transition element cation homeostasis (HP:0011030)1.82707366
176Increased serum lactate (HP:0002151)1.82567261
177Abnormal mitochondria in muscle tissue (HP:0008316)1.82015264
178Concave nail (HP:0001598)1.80979073
179Abnormality of magnesium homeostasis (HP:0004921)1.80460354
180Abnormality of iron homeostasis (HP:0011031)1.80341889
181Anencephaly (HP:0002323)1.78255467
182Abnormal respiratory epithelium morphology (HP:0012253)1.77746925

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.37931815
2FGFR44.51218598
3SIK14.30191065
4ERN14.10857854
5ZAK3.04007501
6ADRBK23.02550113
7INSRR2.92495348
8TAOK32.74996879
9BMPR1B2.71545934
10ERBB42.60790455
11MAP4K22.57444721
12NUAK12.46940277
13TLK12.29554684
14MST1R2.23592181
15CASK2.15213291
16MAP2K42.09885479
17PKN22.06639507
18ACVR1B1.96344652
19MAPK111.82397850
20TXK1.79210303
21MAP3K41.78008019
22PIK3CG1.76084550
23CAMKK21.75446692
24FLT31.75097439
25TRIB31.71937681
26LATS11.71535166
27STK391.70420684
28MAPK131.67443297
29TYK21.56225861
30PTK61.47741851
31ABL21.46839745
32STK38L1.45789428
33MUSK1.45014763
34WNK31.43071475
35DAPK21.41067207
36NEK91.34833466
37WNK41.33310552
38FRK1.32343002
39PINK11.27169824
40FGFR21.26463962
41KDR1.22326670
42MAP3K71.21398076
43PRKAA21.14112559
44JAK21.13558285
45GRK61.10986103
46MAP2K31.10236855
47TNIK1.06341216
48ADRBK11.05641431
49MAP3K31.05216047
50PHKG21.03357104
51PHKG11.03357104
52MAP3K140.99742120
53AKT30.99501509
54OXSR10.98825685
55MKNK20.96852366
56MAPKAPK30.96225047
57EPHB10.95487450
58TBK10.95091780
59PRKCE0.94429847
60VRK10.91812826
61VRK20.90962366
62PRKCZ0.90560367
63JAK10.90042240
64MET0.89986830
65ERBB20.89814468
66MAPK40.89396769
67MARK10.89253962
68TIE10.88553736
69MAP3K100.87876630
70PIK3CA0.86768415
71STK160.85618349
72BRSK20.84989239
73DYRK20.84912510
74MST40.84717850
75PDK40.80289289
76PDK30.80289289
77MAP3K110.78932353
78MAP2K70.78439699
79SGK30.78332224
80MAPK120.77199693
81DYRK1B0.76928770
82PLK20.75966357
83GSK3A0.75315519
84CDK60.74473207
85TGFBR10.74247484
86MAPK150.74214431
87CSNK1G20.73196697
88PRKACG0.73003247
89TGFBR20.72408137
90NME10.72358946
91PRKAA10.71048393
92EPHA30.69971647
93BCR0.69144620
94NTRK30.69096930
95CSNK1G30.69009888
96OBSCN0.68201977
97PTK20.68130214
98MAPKAPK50.65234465
99CSK0.64945371
100SGK4940.64936566
101SGK2230.64936566
102SGK20.64136176
103KIT0.64028282
104MAP2K60.63515579
105CAMK1D0.60040067
106IRAK30.59982820
107NTRK20.59442680
108TRIM280.59413207
109CAMK2G0.59338422
110TEC0.58927745
111PRKACA0.58302439
112STK110.58056133
113CAMK2A0.57931908
114PDPK10.57171210
115RIPK10.56592383
116ERBB30.56008494
117SIK20.54304442
118CSNK1A1L0.53063630
119RPS6KA50.52498990
120ITK0.51960775
121FGFR30.51531902
122PLK30.50245228
123IKBKB0.49770268
124MAP2K20.49081630
125MAPK70.48828294
126PRKCQ0.48558829
127NEK20.48246419
128TAOK20.47439888
129CAMK10.46183212
130CAMKK10.45797460
131IKBKE0.45318025
132CSF1R0.45268777
133TNK20.44879532
134GRK10.43263438
135PNCK0.42597917
136EPHA40.42105657
137PRKCI0.41497419
138IGF1R0.40941817
139MAP2K10.39493493
140CSNK1A10.38762079
141MAP3K50.38135647
142PDK10.37064243
143PDK20.36871497
144PRKG10.36844918
145CDK80.36792689
146MAP3K130.36407529
147PTK2B0.36128246
148GRK50.36122309
149CDK40.35727407
150CSNK1G10.35697056
151PRKD30.35332532
152NEK10.35252158
153PRKCG0.35141463
154CSNK1D0.35085889
155MTOR0.34398992
156RET0.33358738
157MKNK10.32833624
158ICK0.32615023
159CAMK40.28885433
160EGFR0.28608407
161STK380.28423709
162PBK0.28201735
163PRKCA0.25906814
164MAP3K60.25600523
165PKN10.25571004
166PAK30.22956700
167MAP3K10.22919973
168BMX0.22438982
169IRAK10.20779437

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.33455989
2Nitrogen metabolism_Homo sapiens_hsa009103.43985916
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.40060676
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.32545606
5Arginine biosynthesis_Homo sapiens_hsa002203.01039332
6Tryptophan metabolism_Homo sapiens_hsa003802.71672534
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.65607523
8Complement and coagulation cascades_Homo sapiens_hsa046102.60550735
9* Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.59619503
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.57468027
11Fatty acid degradation_Homo sapiens_hsa000712.55285483
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.51332819
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.33778483
14Butanoate metabolism_Homo sapiens_hsa006502.32775410
15Peroxisome_Homo sapiens_hsa041462.15190542
16Phototransduction_Homo sapiens_hsa047442.09948486
17Propanoate metabolism_Homo sapiens_hsa006402.08347658
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.08308204
19Chemical carcinogenesis_Homo sapiens_hsa052041.88392470
20Histidine metabolism_Homo sapiens_hsa003401.87845240
21PPAR signaling pathway_Homo sapiens_hsa033201.86836413
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.86035240
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.85757870
24Fatty acid metabolism_Homo sapiens_hsa012121.85360709
25Oxidative phosphorylation_Homo sapiens_hsa001901.82601814
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.81665648
27beta-Alanine metabolism_Homo sapiens_hsa004101.76937730
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.71343959
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.70642569
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.67158395
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.66329133
32Retinol metabolism_Homo sapiens_hsa008301.64819825
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.64299623
34Staphylococcus aureus infection_Homo sapiens_hsa051501.62417390
35Caffeine metabolism_Homo sapiens_hsa002321.61871587
36Selenocompound metabolism_Homo sapiens_hsa004501.58779056
37Phenylalanine metabolism_Homo sapiens_hsa003601.54585565
38Bile secretion_Homo sapiens_hsa049761.51694270
39Pyruvate metabolism_Homo sapiens_hsa006201.48054142
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.40666661
41Sulfur metabolism_Homo sapiens_hsa009201.39689850
42Tyrosine metabolism_Homo sapiens_hsa003501.39032821
43Parkinsons disease_Homo sapiens_hsa050121.36301361
44Ether lipid metabolism_Homo sapiens_hsa005651.35955174
45Fatty acid elongation_Homo sapiens_hsa000621.31805327
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.31302655
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.31229030
48RNA polymerase_Homo sapiens_hsa030201.29556583
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.29044280
50Starch and sucrose metabolism_Homo sapiens_hsa005001.28535754
51Protein export_Homo sapiens_hsa030601.26105673
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.24007655
53Biosynthesis of amino acids_Homo sapiens_hsa012301.22410855
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.21328549
55Cyanoamino acid metabolism_Homo sapiens_hsa004601.21014280
56Folate biosynthesis_Homo sapiens_hsa007901.20881800
57Carbon metabolism_Homo sapiens_hsa012001.20269877
58Steroid biosynthesis_Homo sapiens_hsa001001.14960976
59ABC transporters_Homo sapiens_hsa020101.13990601
60Nicotine addiction_Homo sapiens_hsa050331.13165804
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11000244
62Fat digestion and absorption_Homo sapiens_hsa049751.10052055
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.05468190
64Vitamin digestion and absorption_Homo sapiens_hsa049770.98552594
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.97356064
66Cardiac muscle contraction_Homo sapiens_hsa042600.96135501
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94821850
68Sulfur relay system_Homo sapiens_hsa041220.93247970
69Vitamin B6 metabolism_Homo sapiens_hsa007500.91268205
70* Arginine and proline metabolism_Homo sapiens_hsa003300.90471055
71Lysine degradation_Homo sapiens_hsa003100.88382323
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86903693
73Huntingtons disease_Homo sapiens_hsa050160.78329141
74Alzheimers disease_Homo sapiens_hsa050100.77696790
75Taste transduction_Homo sapiens_hsa047420.76847158
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76231638
77Morphine addiction_Homo sapiens_hsa050320.75613155
78Glutathione metabolism_Homo sapiens_hsa004800.73699135
79One carbon pool by folate_Homo sapiens_hsa006700.73601334
80Olfactory transduction_Homo sapiens_hsa047400.72842819
81Glycerolipid metabolism_Homo sapiens_hsa005610.70863479
82Serotonergic synapse_Homo sapiens_hsa047260.65404684
83Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.64403725
84Intestinal immune network for IgA production_Homo sapiens_hsa046720.63161656
85Homologous recombination_Homo sapiens_hsa034400.62150701
86Fanconi anemia pathway_Homo sapiens_hsa034600.61324243
87Basal transcription factors_Homo sapiens_hsa030220.59470146
88Pentose phosphate pathway_Homo sapiens_hsa000300.58893837
89RNA degradation_Homo sapiens_hsa030180.54210019
90Insulin secretion_Homo sapiens_hsa049110.53906944
91GABAergic synapse_Homo sapiens_hsa047270.50836637
92Proteasome_Homo sapiens_hsa030500.49247385
93Fatty acid biosynthesis_Homo sapiens_hsa000610.48982788
94* Metabolic pathways_Homo sapiens_hsa011000.47472159
95Salivary secretion_Homo sapiens_hsa049700.40132440
96Purine metabolism_Homo sapiens_hsa002300.38665680
97Circadian rhythm_Homo sapiens_hsa047100.35745571
98Glutamatergic synapse_Homo sapiens_hsa047240.35256227
99Circadian entrainment_Homo sapiens_hsa047130.34965167
100Pyrimidine metabolism_Homo sapiens_hsa002400.34816163
101Collecting duct acid secretion_Homo sapiens_hsa049660.33670523
102Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.32482663
103Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.29856644
104Fructose and mannose metabolism_Homo sapiens_hsa000510.29826035
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28647309
106Galactose metabolism_Homo sapiens_hsa000520.27191091
107Prion diseases_Homo sapiens_hsa050200.26267219
108alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25665754
109Insulin resistance_Homo sapiens_hsa049310.22332964
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.21193006
111Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.20051242
112Linoleic acid metabolism_Homo sapiens_hsa005910.19062589
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.13088856
114Glucagon signaling pathway_Homo sapiens_hsa049220.09071815
115AMPK signaling pathway_Homo sapiens_hsa041520.01810099
116Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2375676
117Bladder cancer_Homo sapiens_hsa05219-0.2282203
118Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2111513
119Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1919012
120Protein digestion and absorption_Homo sapiens_hsa04974-0.1916560
121Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1900653
122Mineral absorption_Homo sapiens_hsa04978-0.1853609
123African trypanosomiasis_Homo sapiens_hsa05143-0.1772849
124Hepatitis C_Homo sapiens_hsa05160-0.1724772
125Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1651342
126Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1622611
127Regulation of autophagy_Homo sapiens_hsa04140-0.1498196
128Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1489144
129Renin-angiotensin system_Homo sapiens_hsa04614-0.1188945
130Insulin signaling pathway_Homo sapiens_hsa04910-0.1178360
131Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1170986
132Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1142313
133Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1046270
134Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0836937
135Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0671823
136Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0324250

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