HNRNPU

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they form complexes with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene contains a RNA binding domain and scaffold-associated region (SAR)-specific bipartite DNA-binding domain. This protein is also thought to be involved in the packaging of hnRNA into large ribonucleoprotein complexes. During apoptosis, this protein is cleaved in a caspase-dependent way. Cleavage occurs at the SALD site, resulting in a loss of DNA-binding activity and a concomitant detachment of this protein from nuclear structural sites. But this cleavage does not affect the function of the encoded protein in RNA metabolism. At least two alternatively spliced transcript variants have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.14986505
2nuclear pore organization (GO:0006999)5.95490808
3DNA unwinding involved in DNA replication (GO:0006268)5.33733906
4mitotic sister chromatid cohesion (GO:0007064)5.16271402
5pre-miRNA processing (GO:0031054)4.70673692
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.60410518
7pore complex assembly (GO:0046931)4.50027097
8protein localization to kinetochore (GO:0034501)4.47515495
9dosage compensation (GO:0007549)4.39445824
10mitotic chromosome condensation (GO:0007076)4.24835712
11regulation of RNA export from nucleus (GO:0046831)4.22864757
12sister chromatid segregation (GO:0000819)4.19729044
13negative regulation of histone methylation (GO:0031061)4.18335063
14regulation of histone H3-K9 methylation (GO:0051570)4.15762074
15negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.07880295
16mitotic nuclear envelope disassembly (GO:0007077)4.00570547
17DNA duplex unwinding (GO:0032508)3.99977687
18DNA geometric change (GO:0032392)3.98189691
19nuclear envelope disassembly (GO:0051081)3.83953479
20membrane disassembly (GO:0030397)3.83953479
21DNA topological change (GO:0006265)3.80601687
22protein localization to chromosome, centromeric region (GO:0071459)3.77477785
23heterochromatin organization (GO:0070828)3.76670984
24DNA replication-dependent nucleosome organization (GO:0034723)3.76248869
25DNA replication-dependent nucleosome assembly (GO:0006335)3.76248869
26double-strand break repair via nonhomologous end joining (GO:0006303)3.70743283
27non-recombinational repair (GO:0000726)3.70743283
28regulation of DNA endoreduplication (GO:0032875)3.68803751
29regulation of sister chromatid cohesion (GO:0007063)3.68315938
30mitotic sister chromatid segregation (GO:0000070)3.67483979
31regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.64246219
32negative regulation of RNA splicing (GO:0033119)3.63018090
33chromatin assembly (GO:0031497)3.61273951
34glucocorticoid receptor signaling pathway (GO:0042921)3.59336717
35protein complex localization (GO:0031503)3.59028113
36negative regulation of mRNA processing (GO:0050686)3.58514535
37kinetochore organization (GO:0051383)3.48717495
38establishment of integrated proviral latency (GO:0075713)3.47190543
39ribosome assembly (GO:0042255)3.44652318
40translesion synthesis (GO:0019985)3.43760156
41peptidyl-lysine dimethylation (GO:0018027)3.42696045
42telomere maintenance via semi-conservative replication (GO:0032201)3.41947241
43regulation of centriole replication (GO:0046599)3.39879471
44regulation of nucleobase-containing compound transport (GO:0032239)3.39258443
45positive regulation of chromosome segregation (GO:0051984)3.38354302
46negative regulation of mRNA metabolic process (GO:1903312)3.37514981
47DNA replication initiation (GO:0006270)3.35088387
48positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.33280632
49positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.33280632
50positive regulation of mitotic sister chromatid separation (GO:1901970)3.33280632
51IMP biosynthetic process (GO:0006188)3.32852792
52positive regulation of cell cycle checkpoint (GO:1901978)3.32124280
53regulation of spindle organization (GO:0090224)3.31428949
54V(D)J recombination (GO:0033151)3.31098589
55DNA synthesis involved in DNA repair (GO:0000731)3.30204941
56alternative mRNA splicing, via spliceosome (GO:0000380)3.30057546
57chromatin assembly or disassembly (GO:0006333)3.30008722
58DNA conformation change (GO:0071103)3.29908587
59cellular protein complex localization (GO:0034629)3.27218798
60* RNA stabilization (GO:0043489)3.27183641
61* mRNA stabilization (GO:0048255)3.27183641
62protein export from nucleus (GO:0006611)3.26951612
63paraxial mesoderm development (GO:0048339)3.26687015
64cytoplasmic mRNA processing body assembly (GO:0033962)3.26443804
65regulation of translational termination (GO:0006449)3.26016461
66negative regulation of DNA repair (GO:0045738)3.25242126
67regulation of centrosome duplication (GO:0010824)3.19981058
68regulation of mitotic spindle organization (GO:0060236)3.17288703
69mitotic metaphase plate congression (GO:0007080)3.16029649
70DNA replication checkpoint (GO:0000076)3.14846546
71spliceosomal tri-snRNP complex assembly (GO:0000244)3.14200482
72telomere maintenance via recombination (GO:0000722)3.13718926
73ATP-dependent chromatin remodeling (GO:0043044)3.10673971
74negative regulation of histone modification (GO:0031057)3.09598107
75DNA strand elongation involved in DNA replication (GO:0006271)3.08758640
76mRNA transport (GO:0051028)3.08582792
77chromosome condensation (GO:0030261)3.07805842
78histone H2A monoubiquitination (GO:0035518)3.06756769
79regulation of translational fidelity (GO:0006450)3.05778119
80DNA replication-independent nucleosome assembly (GO:0006336)3.05568087
81DNA replication-independent nucleosome organization (GO:0034724)3.05568087
82folic acid-containing compound biosynthetic process (GO:0009396)3.04767017
83DNA ligation (GO:0006266)3.04383097
84metaphase plate congression (GO:0051310)3.03730324
85nuclear envelope organization (GO:0006998)3.03034488
86regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.03008161
87regulation of DNA damage checkpoint (GO:2000001)3.02102412
88formation of translation preinitiation complex (GO:0001731)3.01956883
89protein localization to chromosome (GO:0034502)3.01717381
90regulation of centrosome cycle (GO:0046605)2.98922638
91regulation of chromosome segregation (GO:0051983)2.97265087
92regulation of gene silencing by RNA (GO:0060966)2.95081024
93regulation of posttranscriptional gene silencing (GO:0060147)2.95081024
94regulation of gene silencing by miRNA (GO:0060964)2.95081024
95chromatin remodeling at centromere (GO:0031055)2.93004906
96negative regulation of chromatin modification (GO:1903309)2.92717358
97postreplication repair (GO:0006301)2.92377644
98establishment of chromosome localization (GO:0051303)2.92375724
99corticosteroid receptor signaling pathway (GO:0031958)2.92179750
100mRNA export from nucleus (GO:0006406)2.91148737
101mRNA splice site selection (GO:0006376)2.90885036
102DNA strand elongation (GO:0022616)2.90456453
103negative regulation of chromosome segregation (GO:0051985)2.90027709
104monoubiquitinated protein deubiquitination (GO:0035520)2.89269649
105IMP metabolic process (GO:0046040)2.88230883
106regulation of histone H3-K27 methylation (GO:0061085)2.87637192
107nucleic acid transport (GO:0050657)2.87000206
108RNA transport (GO:0050658)2.87000206
109establishment of RNA localization (GO:0051236)2.87000206
110attachment of spindle microtubules to kinetochore (GO:0008608)2.85497550
111mitotic recombination (GO:0006312)2.84914889
112meiotic chromosome segregation (GO:0045132)2.84674162
113positive regulation of RNA splicing (GO:0033120)2.84509711
114regulation of mitotic metaphase/anaphase transition (GO:0030071)2.84110604
115regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.84110604
116DNA packaging (GO:0006323)2.84063271
117sister chromatid cohesion (GO:0007062)2.83608336
118protein-DNA complex disassembly (GO:0032986)2.82959522
119nucleosome disassembly (GO:0006337)2.82959522
120gene silencing by RNA (GO:0031047)2.82911340
121NLS-bearing protein import into nucleus (GO:0006607)2.82866494
122regulation of sister chromatid segregation (GO:0033045)2.82844588
123regulation of mitotic sister chromatid separation (GO:0010965)2.82844588
124regulation of mitotic sister chromatid segregation (GO:0033047)2.82844588
125chromosome segregation (GO:0007059)2.82335349
1263-UTR-mediated mRNA stabilization (GO:0070935)2.82002573
127RNA export from nucleus (GO:0006405)2.81499383
128spindle checkpoint (GO:0031577)2.81431173
129regulation of helicase activity (GO:0051095)2.81409526
130* regulation of mRNA stability (GO:0043488)2.80446342

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.24654646
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.53872726
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.06077212
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.29947724
5* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.25408809
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.07796440
7MYC_22102868_ChIP-Seq_BL_Human2.95960080
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.80579349
9E2F1_21310950_ChIP-Seq_MCF-7_Human2.65837712
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.53541960
11AR_21909140_ChIP-Seq_LNCAP_Human2.48438145
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.41667358
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.40371707
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.24500361
15RBPJ_22232070_ChIP-Seq_NCS_Mouse2.11338701
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.02082150
17E2F7_22180533_ChIP-Seq_HELA_Human11.6011217
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.99694460
19CIITA_25753668_ChIP-Seq_RAJI_Human1.94209125
20* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.90029757
21TP63_19390658_ChIP-ChIP_HaCaT_Human1.88624150
22MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.74542120
23MYCN_18555785_ChIP-Seq_MESCs_Mouse1.74215274
24YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62404135
25* XRN2_22483619_ChIP-Seq_HELA_Human1.61208014
26SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.58536941
27ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.56242749
28CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.56107915
29ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.55018573
30KDM5A_27292631_Chip-Seq_BREAST_Human1.53338732
31POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.51187059
32SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.47705228
33ZFX_18555785_ChIP-Seq_MESCs_Mouse1.44532471
34* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42427719
35HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.42315104
36PKCTHETA_26484144_Chip-Seq_BREAST_Human1.41473807
37* TCF7_22412390_ChIP-Seq_EML_Mouse1.40808552
38ESR1_15608294_ChIP-ChIP_MCF-7_Human1.40605790
39* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.39305774
40SOX2_18555785_ChIP-Seq_MESCs_Mouse1.37084385
41MYC_18358816_ChIP-ChIP_MESCs_Mouse1.33499406
42TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.32817832
43* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.26563335
44WT1_19549856_ChIP-ChIP_CCG9911_Human1.26528106
45* VDR_21846776_ChIP-Seq_THP-1_Human1.25755400
46CHD1_26751641_Chip-Seq_LNCaP_Human1.22670939
47TTF2_22483619_ChIP-Seq_HELA_Human1.21006908
48DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.20678309
49PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.20636593
50KDM2B_26808549_Chip-Seq_DND41_Human1.20071467
51* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.19203612
52ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.18513096
53THAP11_20581084_ChIP-Seq_MESCs_Mouse1.18056615
54SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.17561914
55NANOG_21062744_ChIP-ChIP_HESCs_Human1.16187030
56* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.15969517
57KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14617822
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.14298765
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.13688532
60HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.11752857
61PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11207512
62* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.10344026
63FOXP3_21729870_ChIP-Seq_TREG_Human1.10016513
64CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08643591
65ELK1_19687146_ChIP-ChIP_HELA_Human1.08604898
66DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08357949
67VDR_23849224_ChIP-Seq_CD4+_Human1.07148212
68* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06189645
69WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.05775942
70* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04504193
71FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.04401158
72POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.03658883
73ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.03245019
74MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.02798024
75* UTX_26944678_Chip-Seq_JUKART_Human1.01101262
76ZFP281_18757296_ChIP-ChIP_E14_Mouse0.98674382
77CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.98501236
78E2F1_18555785_ChIP-Seq_MESCs_Mouse0.95608500
79ZNF263_19887448_ChIP-Seq_K562_Human0.95097288
80SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.94825069
81NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.94324429
82ERG_20887958_ChIP-Seq_HPC-7_Mouse0.94105566
83HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.93653728
84STAT3_1855785_ChIP-Seq_MESCs_Mouse0.93546942
85* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.92865575
86TFEB_21752829_ChIP-Seq_HELA_Human0.92829625
87TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92219377
88CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89286024
89SOX17_20123909_ChIP-Seq_XEN_Mouse0.89003416
90KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.88720619
91TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88571582
92* GABP_19822575_ChIP-Seq_HepG2_Human0.88439040
93P300_27058665_Chip-Seq_ZR-75-30cells_Human0.87654437
94ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.86494600
95* MYB_26560356_Chip-Seq_TH1_Human0.86265073
96KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.86132309
97KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.86132309
98KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.86132309
99GATA1_22025678_ChIP-Seq_K562_Human0.85720517
100HOXB4_20404135_ChIP-ChIP_EML_Mouse0.85141345
101TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.85013128
102* NCOR1_26117541_ChIP-Seq_K562_Human0.84988627
103CLOCK_20551151_ChIP-Seq_293T_Human0.84529937
104MAF_26560356_Chip-Seq_TH1_Human0.83815637
105EST1_17652178_ChIP-ChIP_JURKAT_Human0.83636611
106CREB1_15753290_ChIP-ChIP_HEK293T_Human0.83300891
107TCF3_18692474_ChIP-Seq_MESCs_Mouse0.83238505
108TCF3_18692474_ChIP-Seq_MEFs_Mouse0.82987191
109STAT6_21828071_ChIP-Seq_BEAS2B_Human0.82675729
110SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.82331295
111NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.82272937
112MYB_26560356_Chip-Seq_TH2_Human0.81213367
113* KDM2B_26808549_Chip-Seq_JURKAT_Human0.80210021
114FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.80056534
115DCP1A_22483619_ChIP-Seq_HELA_Human0.80053914
116DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.79943423
117* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.79818461
118GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.76953972
119EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.75452636
120HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.75431322

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.75743032
2MP0003111_abnormal_nucleus_morphology3.53452827
3MP0008057_abnormal_DNA_replication3.18275933
4MP0010352_gastrointestinal_tract_polyps3.10797344
5MP0003693_abnormal_embryo_hatching3.10476715
6MP0003123_paternal_imprinting3.02329444
7MP0004957_abnormal_blastocyst_morpholog3.01433460
8MP0003077_abnormal_cell_cycle3.00330917
9MP0005076_abnormal_cell_differentiation2.67788833
10MP0010307_abnormal_tumor_latency2.46907236
11MP0003121_genomic_imprinting2.41535301
12MP0003705_abnormal_hypodermis_morpholog2.41312025
13MP0001730_embryonic_growth_arrest2.35235299
14MP0000537_abnormal_urethra_morphology2.28469782
15MP0008007_abnormal_cellular_replicative2.22611246
16MP0008877_abnormal_DNA_methylation2.22527733
17MP0000350_abnormal_cell_proliferation2.19410173
18MP0004197_abnormal_fetal_growth/weight/2.16771701
19MP0010234_abnormal_vibrissa_follicle2.01734527
20MP0008058_abnormal_DNA_repair2.00465607
21* MP0002084_abnormal_developmental_patter1.96747018
22MP0002396_abnormal_hematopoietic_system1.96721290
23MP0000569_abnormal_digit_pigmentation1.91192970
24* MP0005380_embryogenesis_phenotype1.89670005
25* MP0001672_abnormal_embryogenesis/_devel1.89670005
26MP0001697_abnormal_embryo_size1.81458424
27MP0003787_abnormal_imprinting1.81036324
28* MP0002085_abnormal_embryonic_tissue1.78649886
29MP0004808_abnormal_hematopoietic_stem1.77902339
30MP0009053_abnormal_anal_canal1.77270122
31MP0003890_abnormal_embryonic-extraembry1.76825170
32* MP0003984_embryonic_growth_retardation1.76008003
33* MP0002086_abnormal_extraembryonic_tissu1.74711887
34* MP0002088_abnormal_embryonic_growth/wei1.74212836
35MP0003567_abnormal_fetal_cardiomyocyte1.69717091
36MP0004185_abnormal_adipocyte_glucose1.69427202
37MP0008932_abnormal_embryonic_tissue1.69404058
38MP0009697_abnormal_copulation1.58458476
39* MP0002080_prenatal_lethality1.55059035
40MP0010030_abnormal_orbit_morphology1.53775903
41MP0001293_anophthalmia1.42748245
42MP0009672_abnormal_birth_weight1.38539257
43MP0003119_abnormal_digestive_system1.38506788
44MP0009703_decreased_birth_body1.37826034
45MP0003115_abnormal_respiratory_system1.34072851
46MP0000428_abnormal_craniofacial_morphol1.33782458
47MP0009278_abnormal_bone_marrow1.30346485
48MP0005187_abnormal_penis_morphology1.24475847
49MP0003937_abnormal_limbs/digits/tail_de1.24259178
50MP0002877_abnormal_melanocyte_morpholog1.24164470
51MP0000733_abnormal_muscle_development1.23702475
52MP0003300_gastrointestinal_ulcer1.21487270
53MP0006054_spinal_hemorrhage1.21246989
54MP0001849_ear_inflammation1.18156607
55MP0001346_abnormal_lacrimal_gland1.17858923
56MP0003221_abnormal_cardiomyocyte_apopto1.15642925
57MP0003935_abnormal_craniofacial_develop1.12023944
58MP0000490_abnormal_crypts_of1.11959080
59MP0000703_abnormal_thymus_morphology1.10491310
60MP0000313_abnormal_cell_death1.10098358
61MP0003786_premature_aging1.07883729
62MP0002092_abnormal_eye_morphology1.07623970
63MP0002697_abnormal_eye_size1.05240320
64MP0002925_abnormal_cardiovascular_devel1.04854740
65MP0001915_intracranial_hemorrhage1.04337189
66MP0003861_abnormal_nervous_system1.02368681
67MP0002210_abnormal_sex_determination1.00406199
68MP0003385_abnormal_body_wall0.99861692
69MP0005623_abnormal_meninges_morphology0.98853557
70MP0002019_abnormal_tumor_incidence0.98191624
71MP0000432_abnormal_head_morphology0.97377906
72MP0003566_abnormal_cell_adhesion0.95422876
73MP0000566_synostosis0.92147058
74MP0005384_cellular_phenotype0.91167449
75MP0003943_abnormal_hepatobiliary_system0.89740682
76MP0003122_maternal_imprinting0.89589532
77MP0001145_abnormal_male_reproductive0.89316407
78MP0001545_abnormal_hematopoietic_system0.89277117
79MP0005397_hematopoietic_system_phenotyp0.89277117
80MP0002111_abnormal_tail_morphology0.88890365
81MP0002006_tumorigenesis0.88000872
82MP0003315_abnormal_perineum_morphology0.86440816
83MP0010678_abnormal_skin_adnexa0.86429570
84MP0001661_extended_life_span0.84028677
85MP0005409_darkened_coat_color0.83779345
86MP0002166_altered_tumor_susceptibility0.83002749
87MP0010630_abnormal_cardiac_muscle0.80498304
88MP0001286_abnormal_eye_development0.80421723
89MP0003091_abnormal_cell_migration0.79886872
90MP0002233_abnormal_nose_morphology0.79610844
91MP0001188_hyperpigmentation0.79489040
92MP0003755_abnormal_palate_morphology0.79117220
93MP0003283_abnormal_digestive_organ0.78542082
94MP0008770_decreased_survivor_rate0.78351379
95MP0004264_abnormal_extraembryonic_tissu0.78119473
96MP0003763_abnormal_thymus_physiology0.77933709
97MP0002653_abnormal_ependyma_morphology0.77373421
98MP0001299_abnormal_eye_distance/0.77064279
99MP0002009_preneoplasia0.76986693
100MP0004233_abnormal_muscle_weight0.76862551
101MP0001929_abnormal_gametogenesis0.74571406
102MP0003942_abnormal_urinary_system0.74510116
103MP0005367_renal/urinary_system_phenotyp0.73847118
104MP0000516_abnormal_urinary_system0.73847118
105MP0003941_abnormal_skin_development0.73666627
106MP0000653_abnormal_sex_gland0.73567699
107MP0005248_abnormal_Harderian_gland0.73510191
108MP0000266_abnormal_heart_morphology0.73455227
109MP0001784_abnormal_fluid_regulation0.72764266
110MP0002081_perinatal_lethality0.72678561
111MP0002114_abnormal_axial_skeleton0.72177516
112MP0002116_abnormal_craniofacial_bone0.67924372
113MP0002398_abnormal_bone_marrow0.67439613
114MP0001177_atelectasis0.67430543
115MP0005621_abnormal_cell_physiology0.67072807
116MP0000534_abnormal_ureter_morphology0.66430556
117MP0005666_abnormal_adipose_tissue0.65253596
118MP0002796_impaired_skin_barrier0.64782425
119MP0002249_abnormal_larynx_morphology0.64437251
120MP0003453_abnormal_keratinocyte_physiol0.63966653
121MP0005501_abnormal_skin_physiology0.63465444
122MP0004782_abnormal_surfactant_physiolog0.62986054
123MP0000627_abnormal_mammary_gland0.60869216
124MP0001340_abnormal_eyelid_morphology0.59743815

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)3.59415858
2Short 4th metacarpal (HP:0010044)3.50874978
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.50874978
4Ependymoma (HP:0002888)3.39081823
5Medulloblastoma (HP:0002885)3.17161203
6Colon cancer (HP:0003003)3.12839616
7Increased nuchal translucency (HP:0010880)3.08920321
8Abnormality of the astrocytes (HP:0100707)3.04888720
9Astrocytoma (HP:0009592)3.04888720
10Hyperacusis (HP:0010780)2.85893956
11Nephroblastoma (Wilms tumor) (HP:0002667)2.82851798
12Cortical dysplasia (HP:0002539)2.75311602
13Deviation of the thumb (HP:0009603)2.71879394
14Proximal placement of thumb (HP:0009623)2.68809505
15Abnormality of the fingertips (HP:0001211)2.66728956
16Renal duplication (HP:0000075)2.66290674
17Embryonal renal neoplasm (HP:0011794)2.64448504
18Selective tooth agenesis (HP:0001592)2.62044907
19High anterior hairline (HP:0009890)2.61537925
20Abnormality of the 4th metacarpal (HP:0010012)2.59370680
21Asymmetry of the thorax (HP:0001555)2.58044680
22Glioma (HP:0009733)2.53918829
23Neoplasm of the oral cavity (HP:0100649)2.47853295
24Acute myeloid leukemia (HP:0004808)2.43908244
25Renovascular hypertension (HP:0100817)2.43090350
26Rhabdomyosarcoma (HP:0002859)2.36321690
27Basal cell carcinoma (HP:0002671)2.33389768
28Elfin facies (HP:0004428)2.32596992
29Long eyelashes (HP:0000527)2.32043946
30Biliary tract neoplasm (HP:0100574)2.30372034
31Birth length less than 3rd percentile (HP:0003561)2.30368667
32Overlapping toe (HP:0001845)2.30144851
33Subacute progressive viral hepatitis (HP:0006572)2.29754162
34Ectopic kidney (HP:0000086)2.26450116
35Heterotopia (HP:0002282)2.24896704
36Abnormality of the labia minora (HP:0012880)2.23047639
37Macroorchidism (HP:0000053)2.22128803
38Prominent nose (HP:0000448)2.19484176
39Gastrointestinal carcinoma (HP:0002672)2.18676997
40Malignant gastrointestinal tract tumors (HP:0006749)2.18676997
41Obsessive-compulsive behavior (HP:0000722)2.18509282
42Neoplasm of striated muscle (HP:0009728)2.18195605
43Insidious onset (HP:0003587)2.14489979
44Termporal pattern (HP:0011008)2.14489979
45Abnormal number of incisors (HP:0011064)2.14286629
46Overriding aorta (HP:0002623)2.12995575
47Missing ribs (HP:0000921)2.11314415
48Dysmetric saccades (HP:0000641)2.10044006
49Abnormality of the distal phalanx of the thumb (HP:0009617)2.10005314
50Abnormality of chromosome stability (HP:0003220)2.09940663
51Chromsome breakage (HP:0040012)2.09547235
52Broad palm (HP:0001169)2.08567760
53Hepatoblastoma (HP:0002884)2.08047853
54Bowel diverticulosis (HP:0005222)2.07672755
55High pitched voice (HP:0001620)2.07458816
56Pelvic girdle muscle weakness (HP:0003749)2.06118968
57Sandal gap (HP:0001852)2.05927842
58Absent radius (HP:0003974)2.05392821
59Leiomyosarcoma (HP:0100243)2.03634022
60Uterine leiomyosarcoma (HP:0002891)2.03634022
61Spinal cord lesions (HP:0100561)2.02322163
62Syringomyelia (HP:0003396)2.02322163
63Pointed chin (HP:0000307)2.01937255
64Truncal obesity (HP:0001956)2.01181016
65Transitional cell carcinoma of the bladder (HP:0006740)1.97956391
66Supernumerary ribs (HP:0005815)1.97707569
67Cutis marmorata (HP:0000965)1.96983896
68Broad thumb (HP:0011304)1.96326350
69Trigonocephaly (HP:0000243)1.96226140
70Acute lymphatic leukemia (HP:0006721)1.95677034
71Meckel diverticulum (HP:0002245)1.95596505
72Skull defect (HP:0001362)1.95572741
73Deep philtrum (HP:0002002)1.93293704
74Rectal prolapse (HP:0002035)1.92845931
75Cafe-au-lait spot (HP:0000957)1.91487250
76Pseudobulbar signs (HP:0002200)1.91094642
77Abnormality of the calcaneus (HP:0008364)1.91080722
78Shallow orbits (HP:0000586)1.90574365
79Absent frontal sinuses (HP:0002688)1.90482128
80Urethral obstruction (HP:0000796)1.89606311
81Embryonal neoplasm (HP:0002898)1.88845367
82Anal stenosis (HP:0002025)1.88415997
83Skin tags (HP:0010609)1.87448707
84Aplasia/Hypoplasia of the sternum (HP:0006714)1.87361034
85Facial hemangioma (HP:0000329)1.86551173
86Abnormality of the lower motor neuron (HP:0002366)1.86215285
87Spastic diplegia (HP:0001264)1.86087381
88Absent forearm bone (HP:0003953)1.85812185
89Aplasia involving forearm bones (HP:0009822)1.85812185
90Atresia of the external auditory canal (HP:0000413)1.85393281
91Papillary thyroid carcinoma (HP:0002895)1.85199962
92Abnormality of the ileum (HP:0001549)1.84552738
93Progressive external ophthalmoplegia (HP:0000590)1.83740717
94Abnormality of the preputium (HP:0100587)1.82713331
95Relative macrocephaly (HP:0004482)1.80628184
96Ankyloglossia (HP:0010296)1.80618613
97Increased density of long bones (HP:0006392)1.80183909
98Abnormality of chromosome segregation (HP:0002916)1.79779670
99Fibrous tissue neoplasm (HP:0012316)1.79598669
100Ulnar bowing (HP:0003031)1.79079004
101Chromosomal breakage induced by crosslinking agents (HP:0003221)1.78052054
102Abnormality of the diencephalon (HP:0010662)1.77764263
103Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.77613997
104Bladder neoplasm (HP:0009725)1.77610103
105Bladder carcinoma (HP:0002862)1.77610103
106Radioulnar synostosis (HP:0002974)1.77519880
107Abnormality of the carotid arteries (HP:0005344)1.76857799
108Low anterior hairline (HP:0000294)1.75833193
109Deep palmar crease (HP:0006191)1.74967083
110Broad phalanges of the hand (HP:0009768)1.74857381
111Large earlobe (HP:0009748)1.74726362
112Cutaneous melanoma (HP:0012056)1.74380336
113Aplasia/Hypoplasia of the uvula (HP:0010293)1.72759887
114Shoulder girdle muscle weakness (HP:0003547)1.72488875
115Supernumerary bones of the axial skeleton (HP:0009144)1.72190516
116Abnormal foot bone ossification (HP:0010675)1.71852606
117Patellar aplasia (HP:0006443)1.71617863
118Sacral dimple (HP:0000960)1.71549124
119Agnosia (HP:0010524)1.71522476
120Insomnia (HP:0100785)1.71097248
121Ovarian neoplasm (HP:0100615)1.70680893
122Fibroma (HP:0010614)1.70429983
123Abnormality of oral frenula (HP:0000190)1.70243261
12411 pairs of ribs (HP:0000878)1.69761139
125Esophageal atresia (HP:0002032)1.69118667
126Duplication of thumb phalanx (HP:0009942)1.69031327
127Impulsivity (HP:0100710)1.68541253
128Arnold-Chiari malformation (HP:0002308)1.68069766
129Abnormality of the phalanges of the hallux (HP:0010057)1.67972665
130Flat cornea (HP:0007720)1.67248992
131Myelodysplasia (HP:0002863)1.67170985
132Megalocornea (HP:0000485)1.66915261
133Partial agenesis of the corpus callosum (HP:0001338)1.66696270
134Abnormality of the musculature of the pelvis (HP:0001469)1.66353052
135Abnormality of the hip-girdle musculature (HP:0001445)1.66353052
136Vertebral arch anomaly (HP:0008438)1.66277662
137Enlarged penis (HP:0000040)1.65937488
138Choanal atresia (HP:0000453)1.65925842
139Neoplasm of the small intestine (HP:0100833)1.65752544
140Intestinal polyp (HP:0005266)1.64057859
141Cystic hygroma (HP:0000476)1.63477014
142Narrow palate (HP:0000189)1.63148696
143Cerebral aneurysm (HP:0004944)1.62822087
144Abnormality of cochlea (HP:0000375)1.62704355
145Uterine neoplasm (HP:0010784)1.62347958
146Neoplasm of the adrenal cortex (HP:0100641)1.61881635
147Germ cell neoplasia (HP:0100728)1.59885933
148Multiple enchondromatosis (HP:0005701)1.59775342
149Omphalocele (HP:0001539)1.58857780
150Sparse lateral eyebrow (HP:0005338)1.57700358
151Small intestinal stenosis (HP:0012848)1.56884196

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.79620503
2CDK124.11544622
3EEF2K3.26915662
4NEK22.94258853
5SMG12.69418920
6PKN22.68876561
7MAP3K102.55087326
8BRD42.41311358
9MKNK12.35384373
10SCYL22.21220988
11WEE12.21057817
12SRPK12.01780980
13MKNK22.00528852
14TTK1.89218580
15LATS11.86698513
16PASK1.86024281
17TSSK61.82006354
18NEK11.79130851
19RPS6KB21.77331634
20ALK1.75322998
21ATR1.74161455
22TRIB31.68772135
23CDK41.67534404
24CDK61.62534170
25TAF11.60617086
26CHEK11.48626154
27PLK31.43031036
28PBK1.41787148
29PLK11.30011919
30PNCK1.28996599
31PTK61.28541368
32AURKB1.27614672
33ATM1.24026920
34STK31.23063758
35CDK71.20405769
36CHEK21.18311520
37MTOR1.15252122
38MAP3K81.14043848
39STK101.13195649
40PDGFRA1.12235005
41TGFBR11.09503578
42CDK21.09122058
43EIF2AK31.07562138
44RPS6KA41.04762433
45RIPK11.02978238
46ACVR1B1.02574717
47FGFR11.02309346
48ERBB31.02172233
49BUB11.01349102
50PAK40.97241043
51BRSK20.94813027
52CAMK1D0.92622609
53STK40.89722992
54CAMK1G0.89439747
55TTN0.88451015
56CDK90.87169731
57ICK0.87089852
58FGFR40.87066687
59PRPF4B0.86959320
60CDK10.85854761
61SIK20.85725765
62YES10.83517253
63MELK0.83302806
64AKT30.80208110
65TNIK0.78600247
66FGFR20.78088709
67FGFR30.74702789
68CSNK1D0.74220684
69KSR10.73625705
70PAK20.73087345
71DYRK30.72672796
72EIF2AK20.70979593
73TYRO30.69868114
74* PRKDC0.66244114
75CLK10.65537246
76PDGFRB0.64831838
77BRSK10.62298971
78CDK30.61882836
79MAPK140.61297532
80CSNK1E0.59557146
81EIF2AK10.59195857
82PIM10.57674182
83LRRK20.56388639
84FLT30.56179360
85KSR20.54519654
86DMPK0.54409753
87PLK40.51359980
88BCR0.50826787
89EPHA20.50539026
90AKT20.48217035
91FRK0.47230051
92BRAF0.47132825
93GSK3B0.47039050
94STK38L0.46405226
95NEK90.45869418
96CSNK1A1L0.45483263
97NLK0.44686948
98TLK10.44520330
99RPS6KB10.44095233
100WNK10.43954576
101CDK80.43862240
102MAP4K10.43843750
103MAP3K140.43680096
104AKT10.42930420
105PRKD30.41323723
106CSNK2A20.41055997
107MAP3K130.38424197
108MAPK10.37882724
109MST1R0.37527411
110TESK20.37013607
111BMX0.35953164
112RAF10.35888336
113MAPK80.35879595
114MAPK100.35026724
115CDK180.34542529
116AURKA0.34203120
117ERBB40.33954313
118CDK150.33753597
119SGK30.33051855
120LATS20.32750416
121CDK11A0.32709091
122RET0.29124510
123MAP2K30.28716559
124GRK60.27753292
125RPS6KA10.26551772
126MARK30.26059805
127MAPK90.25428503
128CHUK0.24305223

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.43120672
2Mismatch repair_Homo sapiens_hsa034303.02306634
3* Spliceosome_Homo sapiens_hsa030402.79422284
4RNA transport_Homo sapiens_hsa030132.77562480
5Cell cycle_Homo sapiens_hsa041102.70591739
6mRNA surveillance pathway_Homo sapiens_hsa030152.58725864
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.48967421
8One carbon pool by folate_Homo sapiens_hsa006702.11170237
9Base excision repair_Homo sapiens_hsa034102.03164787
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.92914913
11Nucleotide excision repair_Homo sapiens_hsa034201.80385616
12Homologous recombination_Homo sapiens_hsa034401.72866556
13Fanconi anemia pathway_Homo sapiens_hsa034601.71458588
14Non-homologous end-joining_Homo sapiens_hsa034501.66305627
15MicroRNAs in cancer_Homo sapiens_hsa052061.60168870
16RNA degradation_Homo sapiens_hsa030181.57883751
17Systemic lupus erythematosus_Homo sapiens_hsa053221.51174518
18Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.50184277
19Chronic myeloid leukemia_Homo sapiens_hsa052201.50155537
20Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.49398591
21Colorectal cancer_Homo sapiens_hsa052101.44125438
22Viral carcinogenesis_Homo sapiens_hsa052031.42330369
23Oocyte meiosis_Homo sapiens_hsa041141.40579036
24HTLV-I infection_Homo sapiens_hsa051661.33048749
25Basal cell carcinoma_Homo sapiens_hsa052171.32136042
26mTOR signaling pathway_Homo sapiens_hsa041501.31747517
27Small cell lung cancer_Homo sapiens_hsa052221.31554543
28Lysine degradation_Homo sapiens_hsa003101.27453776
29p53 signaling pathway_Homo sapiens_hsa041151.26593114
30Hippo signaling pathway_Homo sapiens_hsa043901.24430406
31Endometrial cancer_Homo sapiens_hsa052131.23471059
32Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.23244935
33Antigen processing and presentation_Homo sapiens_hsa046121.19786789
34Adherens junction_Homo sapiens_hsa045201.19433428
35Thyroid cancer_Homo sapiens_hsa052161.19312821
36Transcriptional misregulation in cancer_Homo sapiens_hsa052021.15832019
37Non-small cell lung cancer_Homo sapiens_hsa052231.13456763
38Biosynthesis of amino acids_Homo sapiens_hsa012301.08457838
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.08159900
40Central carbon metabolism in cancer_Homo sapiens_hsa052301.05602337
41Notch signaling pathway_Homo sapiens_hsa043301.03854954
42Proteoglycans in cancer_Homo sapiens_hsa052051.03580182
43Thyroid hormone signaling pathway_Homo sapiens_hsa049191.03503765
44TGF-beta signaling pathway_Homo sapiens_hsa043501.02028605
45Alcoholism_Homo sapiens_hsa050341.01371034
46Herpes simplex infection_Homo sapiens_hsa051681.00513344
47Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.95683600
48Prostate cancer_Homo sapiens_hsa052150.93996798
49Epstein-Barr virus infection_Homo sapiens_hsa051690.93960073
50Glioma_Homo sapiens_hsa052140.92232249
51Basal transcription factors_Homo sapiens_hsa030220.91875477
52Pancreatic cancer_Homo sapiens_hsa052120.88422935
53Viral myocarditis_Homo sapiens_hsa054160.88189070
54Wnt signaling pathway_Homo sapiens_hsa043100.87889486
55Hedgehog signaling pathway_Homo sapiens_hsa043400.83998242
56Neurotrophin signaling pathway_Homo sapiens_hsa047220.82961746
57Hepatitis B_Homo sapiens_hsa051610.81566721
58Pathways in cancer_Homo sapiens_hsa052000.78375560
59Acute myeloid leukemia_Homo sapiens_hsa052210.77078409
60B cell receptor signaling pathway_Homo sapiens_hsa046620.74751538
61Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73788111
62T cell receptor signaling pathway_Homo sapiens_hsa046600.73505754
63Focal adhesion_Homo sapiens_hsa045100.72929109
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.72268099
65Dorso-ventral axis formation_Homo sapiens_hsa043200.71913035
66Inositol phosphate metabolism_Homo sapiens_hsa005620.70499169
67FoxO signaling pathway_Homo sapiens_hsa040680.69785756
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.69540269
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.67208891
70Bladder cancer_Homo sapiens_hsa052190.66843136
71Estrogen signaling pathway_Homo sapiens_hsa049150.66842368
72Tight junction_Homo sapiens_hsa045300.66538382
73Choline metabolism in cancer_Homo sapiens_hsa052310.65436518
74Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63547932
75Renal cell carcinoma_Homo sapiens_hsa052110.61267940
76Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.60830657
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60768728
78Primary immunodeficiency_Homo sapiens_hsa053400.60106025
79HIF-1 signaling pathway_Homo sapiens_hsa040660.59713220
80Selenocompound metabolism_Homo sapiens_hsa004500.59574557
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.58791017
82Vitamin B6 metabolism_Homo sapiens_hsa007500.58164963
83Pyrimidine metabolism_Homo sapiens_hsa002400.57755178
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57391535
85Pentose phosphate pathway_Homo sapiens_hsa000300.56566732
86VEGF signaling pathway_Homo sapiens_hsa043700.55556359
87ErbB signaling pathway_Homo sapiens_hsa040120.52515938
88Apoptosis_Homo sapiens_hsa042100.52510807
89RNA polymerase_Homo sapiens_hsa030200.52356571
90Prolactin signaling pathway_Homo sapiens_hsa049170.50210725
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50132069
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49796866
93Carbon metabolism_Homo sapiens_hsa012000.49451372
94Platelet activation_Homo sapiens_hsa046110.49341730
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48851043
96Melanoma_Homo sapiens_hsa052180.47378653
97AMPK signaling pathway_Homo sapiens_hsa041520.46944630
98Long-term potentiation_Homo sapiens_hsa047200.45791713
99Melanogenesis_Homo sapiens_hsa049160.44591838
100Toxoplasmosis_Homo sapiens_hsa051450.44198021
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42882454
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41907622
103Rap1 signaling pathway_Homo sapiens_hsa040150.41610515
104Insulin signaling pathway_Homo sapiens_hsa049100.41512342
105PI3K-Akt signaling pathway_Homo sapiens_hsa041510.41436292
106Influenza A_Homo sapiens_hsa051640.41372716
107Measles_Homo sapiens_hsa051620.40374510
108Glucagon signaling pathway_Homo sapiens_hsa049220.39350312
109Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.38362252
110MAPK signaling pathway_Homo sapiens_hsa040100.38318477
111Type II diabetes mellitus_Homo sapiens_hsa049300.37269848
112Insulin resistance_Homo sapiens_hsa049310.37133328
113Gap junction_Homo sapiens_hsa045400.35706272
114Purine metabolism_Homo sapiens_hsa002300.35541389
115Thyroid hormone synthesis_Homo sapiens_hsa049180.33372308
116Pyruvate metabolism_Homo sapiens_hsa006200.30557574

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