HNRNPKP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450917.56284488
2DNA deamination (GO:0045006)7.01560683
3cytidine deamination (GO:0009972)6.99808783
4cytidine metabolic process (GO:0046087)6.99808783
5cytidine catabolic process (GO:0006216)6.99808783
6Arp2/3 complex-mediated actin nucleation (GO:0034314)6.95393007
7actin nucleation (GO:0045010)6.25476525
8pyrimidine ribonucleoside catabolic process (GO:0046133)6.12210471
9negative T cell selection (GO:0043383)5.05587450
10sequestering of actin monomers (GO:0042989)4.96538897
11cellular response to interleukin-15 (GO:0071350)4.56610522
12positive regulation of natural killer cell mediated immunity (GO:0002717)4.43601800
13positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.29825121
14negative thymic T cell selection (GO:0045060)4.24709537
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.17259984
16positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.06302170
17positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.93055018
18negative regulation of T cell apoptotic process (GO:0070233)3.87667249
19regulation of natural killer cell mediated immunity (GO:0002715)3.83454209
20regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.83454209
21positive T cell selection (GO:0043368)3.82708902
22positive thymic T cell selection (GO:0045059)3.74276508
23adaptation of signaling pathway (GO:0023058)3.73874545
24positive regulation of defense response to virus by host (GO:0002230)3.71404135
25regulation of B cell receptor signaling pathway (GO:0050855)3.66344007
26positive regulation of T cell mediated cytotoxicity (GO:0001916)3.63448225
27regulation of leukocyte mediated cytotoxicity (GO:0001910)3.61989472
28negative regulation of stress fiber assembly (GO:0051497)3.61187806
29positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.58606758
30positive regulation of cell killing (GO:0031343)3.53485769
31mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.50604455
32negative regulation by host of viral transcription (GO:0043922)3.49628774
33mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.47810529
34thymic T cell selection (GO:0045061)3.47368064
35purine deoxyribonucleotide catabolic process (GO:0009155)3.46222559
36T cell migration (GO:0072678)3.44541283
37regulation of gamma-delta T cell differentiation (GO:0045586)3.38964156
38platelet dense granule organization (GO:0060155)3.37427256
39positive regulation of alpha-beta T cell proliferation (GO:0046641)3.33627398
40response to interleukin-15 (GO:0070672)3.32377258
41deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.30459521
42ATP synthesis coupled proton transport (GO:0015986)3.29997902
43energy coupled proton transport, down electrochemical gradient (GO:0015985)3.29997902
44positive regulation of interleukin-8 secretion (GO:2000484)3.29517049
45iron-sulfur cluster assembly (GO:0016226)3.24973065
46metallo-sulfur cluster assembly (GO:0031163)3.24973065
47regulation of cellular amino acid metabolic process (GO:0006521)3.24596534
48positive regulation of calcium-mediated signaling (GO:0050850)3.24410176
49regulation of cell killing (GO:0031341)3.19167922
50regulation of T cell receptor signaling pathway (GO:0050856)3.18036895
51regulation of activation of Janus kinase activity (GO:0010533)3.17751735
52regulation of T cell mediated cytotoxicity (GO:0001914)3.14601351
53regulation of regulatory T cell differentiation (GO:0045589)3.13872285
54pyrimidine nucleoside catabolic process (GO:0046135)3.12433745
55cytolysis (GO:0019835)3.05949063
56antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.05651366
57DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.03432016
58T cell receptor signaling pathway (GO:0050852)3.03403739
59negative regulation of lymphocyte apoptotic process (GO:0070229)3.00320706
60purine deoxyribonucleotide metabolic process (GO:0009151)2.98770610
61negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.98169304
62RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.97404048
63tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.97404048
64protein neddylation (GO:0045116)2.97365956
65response to interferon-beta (GO:0035456)2.97197564
66water-soluble vitamin biosynthetic process (GO:0042364)2.94061840
67negative regulation of actin filament bundle assembly (GO:0032232)2.94029924
68intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.92279567
69signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.92279567
70regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.91204396
71regulation of isotype switching to IgG isotypes (GO:0048302)2.90969694
72T cell costimulation (GO:0031295)2.90849453
73T cell selection (GO:0045058)2.90786078
74negative regulation of viral genome replication (GO:0045071)2.90741115
75signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.90653615
76signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.90653615
77signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.90653615
78cellular defense response (GO:0006968)2.89428118
79lymphocyte costimulation (GO:0031294)2.87319892
80positive regulation of uterine smooth muscle contraction (GO:0070474)2.86870725
81respiratory electron transport chain (GO:0022904)2.86543449
82positive regulation of gamma-delta T cell activation (GO:0046645)2.86174571
83positive regulation of prostaglandin secretion (GO:0032308)2.85440005
84antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.85419785
85negative regulation of nitric-oxide synthase activity (GO:0051001)2.84370058
86electron transport chain (GO:0022900)2.84236285
87protein deneddylation (GO:0000338)2.83912396
88negative regulation of mast cell activation (GO:0033004)2.82884088
89regulation of interleukin-8 secretion (GO:2000482)2.82158803
90regulation of defense response to virus by host (GO:0050691)2.80809486
91protein complex biogenesis (GO:0070271)2.78417231
92base-excision repair, AP site formation (GO:0006285)2.77702543
93deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.74375416
94signal transduction involved in DNA damage checkpoint (GO:0072422)2.74318967
95signal transduction involved in DNA integrity checkpoint (GO:0072401)2.74318967
96negative regulation of oxidoreductase activity (GO:0051354)2.74007142
97regulation of interleukin-2 biosynthetic process (GO:0045076)2.72898918
98signal transduction involved in cell cycle checkpoint (GO:0072395)2.72158762
99mast cell activation (GO:0045576)2.71154158
100positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.69764624

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.61075213
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.28718492
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.65376354
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.45853468
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.38306671
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.11494825
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.08394357
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.91051524
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.83751466
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.62659755
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.52235560
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.43917064
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.41505950
14MYB_26560356_Chip-Seq_TH2_Human2.32634874
15VDR_23849224_ChIP-Seq_CD4+_Human2.31329627
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.26325825
17ZNF274_21170338_ChIP-Seq_K562_Hela2.19198998
18VDR_22108803_ChIP-Seq_LS180_Human2.18956645
19SRF_21415370_ChIP-Seq_HL-1_Mouse2.08237561
20IRF8_21731497_ChIP-ChIP_J774_Mouse2.06464157
21FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.05697990
22FOXP3_21729870_ChIP-Seq_TREG_Human1.96255170
23RUNX_20019798_ChIP-Seq_JUKART_Human1.95646561
24LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.94247595
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.92562882
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.90947605
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.87245333
28ETS1_20019798_ChIP-Seq_JURKAT_Human1.82200879
29GATA3_27048872_Chip-Seq_THYMUS_Human1.81028489
30NOTCH1_21737748_ChIP-Seq_TLL_Human1.75861639
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.73236471
32SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.69764046
33STAT4_19710469_ChIP-ChIP_TH1__Mouse1.69381881
34PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.67086939
35IGF1R_20145208_ChIP-Seq_DFB_Human1.63057591
36GATA3_26560356_Chip-Seq_TH2_Human1.59098960
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55004412
38RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.50295444
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.48512328
40EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.45656666
41E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.41773144
42UTX_26944678_Chip-Seq_JUKART_Human1.35888242
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33435128
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.33244637
45AR_20517297_ChIP-Seq_VCAP_Human1.33239901
46MYC_18940864_ChIP-ChIP_HL60_Human1.32298065
47EZH2_22144423_ChIP-Seq_EOC_Human1.31449945
48LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.30297245
49PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.29930684
50CIITA_25753668_ChIP-Seq_RAJI_Human1.29609901
51MYB_26560356_Chip-Seq_TH1_Human1.28041603
52STAT6_21828071_ChIP-Seq_BEAS2B_Human1.26547868
53TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.25965150
54RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.25681166
55PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.25448758
56GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.24181402
57TP53_22573176_ChIP-Seq_HFKS_Human1.23609290
58BCL6_27268052_Chip-Seq_Bcells_Human1.22374799
59ELK1_19687146_ChIP-ChIP_HELA_Human1.21401269
60IRF1_19129219_ChIP-ChIP_H3396_Human1.20266258
61TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.18493854
62NANOG_20526341_ChIP-Seq_ESCs_Human1.17484030
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.13764691
64PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12309999
65CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.11606145
66CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10954328
67HTT_18923047_ChIP-ChIP_STHdh_Human1.10912858
68NCOR_22424771_ChIP-Seq_293T_Human1.10849312
69STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.10840803
70TAF2_19829295_ChIP-Seq_ESCs_Human1.10695458
71ERG_20517297_ChIP-Seq_VCAP_Human1.10318385
72GATA3_21878914_ChIP-Seq_MCF-7_Human1.09610267
73SPI1_23547873_ChIP-Seq_NB4_Human1.09315374
74NANOG_19829295_ChIP-Seq_ESCs_Human1.05352199
75SOX2_19829295_ChIP-Seq_ESCs_Human1.05352199
76SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.05005322
77TAF15_26573619_Chip-Seq_HEK293_Human1.04510176
78EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04403546
79CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.04085528
80AUTS2_25519132_ChIP-Seq_293T-REX_Human1.03071246
81ELF1_20517297_ChIP-Seq_JURKAT_Human1.01767761
82TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.00551687
83POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00335041
84FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99496442
85MYC_19829295_ChIP-Seq_ESCs_Human0.99233347
86EWS_26573619_Chip-Seq_HEK293_Human0.99036819
87FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98616755
88FOXA1_25329375_ChIP-Seq_VCAP_Human0.98616755
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95420216
90P300_27268052_Chip-Seq_Bcells_Human0.94865212
91YY1_21170310_ChIP-Seq_MESCs_Mouse0.94739429
92NFE2_27457419_Chip-Seq_LIVER_Mouse0.94405707
93MAF_26560356_Chip-Seq_TH1_Human0.93982064
94FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93881823
95EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.93176106
96ER_23166858_ChIP-Seq_MCF-7_Human0.92896252
97P53_21459846_ChIP-Seq_SAOS-2_Human0.91535630
98CBP_20019798_ChIP-Seq_JUKART_Human0.90282908
99IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90282908
100GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.90266873

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.66585584
2MP0009785_altered_susceptibility_to3.33017494
3MP0003763_abnormal_thymus_physiology3.03510668
4MP0001835_abnormal_antigen_presentation2.76698582
5MP0002166_altered_tumor_susceptibility2.38238737
6MP0001800_abnormal_humoral_immune2.36311761
7MP0005000_abnormal_immune_tolerance2.32707138
8MP0002148_abnormal_hypersensitivity_rea2.23137255
9MP0004147_increased_porphyrin_level2.22495008
10MP0003786_premature_aging2.20377544
11MP0002420_abnormal_adaptive_immunity2.18093506
12MP0005025_abnormal_response_to2.18059983
13MP0001819_abnormal_immune_cell2.12762849
14MP0003866_abnormal_defecation2.10291598
15MP0002723_abnormal_immune_serum2.06324465
16MP0002102_abnormal_ear_morphology2.02888917
17MP0006072_abnormal_retinal_apoptosis1.96001611
18MP0002736_abnormal_nociception_after1.87936939
19MP0009333_abnormal_splenocyte_physiolog1.86365226
20MP0002452_abnormal_antigen_presenting1.85647113
21MP0002006_tumorigenesis1.82088406
22MP0000685_abnormal_immune_system1.81924697
23MP0008875_abnormal_xenobiotic_pharmacok1.77280792
24MP0005387_immune_system_phenotype1.70801654
25MP0001790_abnormal_immune_system1.70801654
26MP0002398_abnormal_bone_marrow1.68871341
27MP0003646_muscle_fatigue1.68491408
28MP0000716_abnormal_immune_system1.64708677
29MP0008872_abnormal_physiological_respon1.63863864
30MP0004145_abnormal_muscle_electrophysio1.63473016
31MP0005645_abnormal_hypothalamus_physiol1.61162550
32MP0002933_joint_inflammation1.58355213
33MP0001968_abnormal_touch/_nociception1.57879789
34MP0002277_abnormal_respiratory_mucosa1.54766172
35MP0006082_CNS_inflammation1.53980414
36MP0000689_abnormal_spleen_morphology1.49174028
37MP0005084_abnormal_gallbladder_morpholo1.48607129
38MP0005646_abnormal_pituitary_gland1.45892269
39MP0005551_abnormal_eye_electrophysiolog1.43337252
40MP0002405_respiratory_system_inflammati1.40503261
41MP0001905_abnormal_dopamine_level1.38590953
42MP0010155_abnormal_intestine_physiology1.37364235
43MP0001845_abnormal_inflammatory_respons1.36679190
44MP0005253_abnormal_eye_physiology1.35065332
45MP0002722_abnormal_immune_system1.34633295
46MP0006054_spinal_hemorrhage1.33936652
47MP0002429_abnormal_blood_cell1.32331810
48MP0001764_abnormal_homeostasis1.32048976
49MP0000703_abnormal_thymus_morphology1.28472226
50MP0008789_abnormal_olfactory_epithelium1.26797063
51MP0003724_increased_susceptibility_to1.25707548
52MP0003252_abnormal_bile_duct1.24632034
53MP0008877_abnormal_DNA_methylation1.21971585
54MP0002876_abnormal_thyroid_physiology1.21076266
55MP0001873_stomach_inflammation1.18557112
56MP0002419_abnormal_innate_immunity1.18395491
57MP0005075_abnormal_melanosome_morpholog1.16055113
58MP0002234_abnormal_pharynx_morphology1.15333475
59MP0005410_abnormal_fertilization1.15020953
60MP0000372_irregular_coat_pigmentation1.14972185
61MP0008469_abnormal_protein_level1.12122542
62MP0010386_abnormal_urinary_bladder1.09716303
63MP0005083_abnormal_biliary_tract1.09660264
64MP0001853_heart_inflammation1.06309002
65MP0009764_decreased_sensitivity_to1.05150546
66MP0002138_abnormal_hepatobiliary_system1.03502798
67MP0006036_abnormal_mitochondrial_physio0.98718043
68MP0001986_abnormal_taste_sensitivity0.97390352
69MP0003045_fibrosis0.95442558
70MP0008058_abnormal_DNA_repair0.93158814
71MP0002693_abnormal_pancreas_physiology0.93095583
72MP0008995_early_reproductive_senescence0.92719128
73MP0003436_decreased_susceptibility_to0.91795452
74MP0003448_altered_tumor_morphology0.91215919
75MP0003806_abnormal_nucleotide_metabolis0.90856355
76MP0003011_delayed_dark_adaptation0.90747659
77MP0001661_extended_life_span0.88181650
78MP0001501_abnormal_sleep_pattern0.88053210
79MP0002019_abnormal_tumor_incidence0.85423766
80MP0002837_dystrophic_cardiac_calcinosis0.85120968
81MP0001765_abnormal_ion_homeostasis0.84101810
82MP0002095_abnormal_skin_pigmentation0.83297446
83MP0003283_abnormal_digestive_organ0.81316144
84MP0009763_increased_sensitivity_to0.80843178
85MP0003195_calcinosis0.80593086
86MP0006276_abnormal_autonomic_nervous0.77102598
87MP0003880_abnormal_central_pattern0.76825739
88MP0005636_abnormal_mineral_homeostasis0.76774077
89MP0005464_abnormal_platelet_physiology0.76539940
90MP0003878_abnormal_ear_physiology0.75480894
91MP0005377_hearing/vestibular/ear_phenot0.75480894
92MP0004885_abnormal_endolymph0.74811398
93MP0009765_abnormal_xenobiotic_induced0.71663109
94MP0004134_abnormal_chest_morphology0.71489079
95MP0009643_abnormal_urine_homeostasis0.67393577
96MP0001542_abnormal_bone_strength0.65688126
97MP0009697_abnormal_copulation0.65657849
98MP0010094_abnormal_chromosome_stability0.65255747
99MP0003137_abnormal_impulse_conducting0.64815870
100MP0001119_abnormal_female_reproductive0.64325638

Predicted human phenotypes

RankGene SetZ-score
1IgG deficiency (HP:0004315)4.97453536
2Severe combined immunodeficiency (HP:0004430)4.67540084
3T lymphocytopenia (HP:0005403)4.58676769
4Abnormality of T cell number (HP:0011839)4.47745572
5Aplastic anemia (HP:0001915)4.45428366
6Increased IgM level (HP:0003496)3.83870710
7Hypoproteinemia (HP:0003075)3.82752369
8Autoimmune hemolytic anemia (HP:0001890)3.79782764
9Mitochondrial inheritance (HP:0001427)3.79439004
10Combined immunodeficiency (HP:0005387)3.72466556
11Acute necrotizing encephalopathy (HP:0006965)3.47315223
12Abnormality of T cells (HP:0002843)3.44621664
13Hepatocellular necrosis (HP:0001404)3.37788694
14Abolished electroretinogram (ERG) (HP:0000550)3.37482031
15Abnormal mitochondria in muscle tissue (HP:0008316)3.35579065
16Abnormality of B cell number (HP:0010975)3.35232199
17Absent rod-and cone-mediated responses on ERG (HP:0007688)3.29832627
18Elevated erythrocyte sedimentation rate (HP:0003565)3.22353601
19Congenital stationary night blindness (HP:0007642)3.21646825
20Chronic diarrhea (HP:0002028)3.18301534
21Increased CSF lactate (HP:0002490)3.13323798
22Thyroiditis (HP:0100646)3.06429081
23Hepatic necrosis (HP:0002605)2.97054987
24B lymphocytopenia (HP:0010976)2.93316842
25Decreased electroretinogram (ERG) amplitude (HP:0000654)2.88905549
26Pancytopenia (HP:0001876)2.86229944
27Abnormality of eosinophils (HP:0001879)2.82830349
28Agammaglobulinemia (HP:0004432)2.77836753
29Acute encephalopathy (HP:0006846)2.75744052
30Renal Fanconi syndrome (HP:0001994)2.75701255
31Abnormal rod and cone electroretinograms (HP:0008323)2.75257935
32Progressive macrocephaly (HP:0004481)2.74283469
33IgM deficiency (HP:0002850)2.69685240
34Stomatitis (HP:0010280)2.66941739
35Increased intramyocellular lipid droplets (HP:0012240)2.66893301
36Abnormality of the prostate (HP:0008775)2.66196415
37Autoimmune thrombocytopenia (HP:0001973)2.65854003
38Decreased central vision (HP:0007663)2.64773075
39Renal cortical cysts (HP:0000803)2.57242586
40Pancreatic cysts (HP:0001737)2.54606038
41Increased hepatocellular lipid droplets (HP:0006565)2.54483747
42Recurrent bronchitis (HP:0002837)2.46806632
43Attenuation of retinal blood vessels (HP:0007843)2.45426137
44Oral leukoplakia (HP:0002745)2.38061312
453-Methylglutaconic aciduria (HP:0003535)2.36716117
46Cerebral edema (HP:0002181)2.36178143
47Cerebral palsy (HP:0100021)2.36125304
48Optic disc pallor (HP:0000543)2.29739548
49Lipid accumulation in hepatocytes (HP:0006561)2.29664137
50Respiratory failure (HP:0002878)2.28309801
51Type I transferrin isoform profile (HP:0003642)2.27490221
52Type 2 muscle fiber atrophy (HP:0003554)2.26379251
53Increased muscle lipid content (HP:0009058)2.25890374
54Abnormality of T cell physiology (HP:0011840)2.25831289
55Methylmalonic aciduria (HP:0012120)2.25300190
56Increased serum lactate (HP:0002151)2.24122483
57Lymphopenia (HP:0001888)2.21553045
58Encephalitis (HP:0002383)2.21504800
59Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.21362714
60Methylmalonic acidemia (HP:0002912)2.19588136
61Hypoalbuminemia (HP:0003073)2.17030349
62Abnormal albumin level (HP:0012116)2.17030349
63Recurrent cutaneous fungal infections (HP:0011370)2.16627625
64Chronic mucocutaneous candidiasis (HP:0002728)2.16627625
65Generalized aminoaciduria (HP:0002909)2.16548216
66Abnormality of the renal cortex (HP:0011035)2.14214599
67Eosinophilia (HP:0001880)2.12324182
68Lactic acidosis (HP:0003128)2.09066296
69Abnormality of cells of the lymphoid lineage (HP:0012140)2.09050781
70Dicarboxylic aciduria (HP:0003215)2.08516681
71Abnormality of dicarboxylic acid metabolism (HP:0010995)2.08516681
72Decreased activity of mitochondrial respiratory chain (HP:0008972)2.08265715
73Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.08265715
74Abnormality of the renal collecting system (HP:0004742)2.04786095
75Pancreatic fibrosis (HP:0100732)2.04106008
76Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.03833174
77Molar tooth sign on MRI (HP:0002419)2.03599992
78Abnormality of midbrain morphology (HP:0002418)2.03599992
79Bronchitis (HP:0012387)1.97909137
80Joint swelling (HP:0001386)1.97520328
81Granulocytopenia (HP:0001913)1.96886969
82Pendular nystagmus (HP:0012043)1.95644083
83True hermaphroditism (HP:0010459)1.95579681
84Aplasia/hypoplasia of the uterus (HP:0008684)1.95451757
85Mesangial abnormality (HP:0001966)1.94828674
86Keratoconus (HP:0000563)1.94605444
87Increased corneal curvature (HP:0100692)1.94605444
88Severe visual impairment (HP:0001141)1.91359913
89Recurrent fungal infections (HP:0002841)1.90067825
90Neonatal respiratory distress (HP:0002643)1.89623558
91Meningitis (HP:0001287)1.88815025
92Hypoplasia of the thymus (HP:0000778)1.82478673
93Constricted visual fields (HP:0001133)1.82415249
94Exercise intolerance (HP:0003546)1.81716107
95Muscle fiber atrophy (HP:0100295)1.81432339
96Hypergammaglobulinemia (HP:0010702)1.80186816
97Short tibia (HP:0005736)1.79480193
98Leukocytosis (HP:0001974)1.78541599
99Colon cancer (HP:0003003)1.77505926
100Lethargy (HP:0001254)1.76369665

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.28476760
2KDR5.74137375
3TESK25.17984317
4BCKDK3.08126079
5TAOK32.89069795
6VRK22.36199271
7MAP4K12.31148323
8TIE12.30699009
9ITK2.24374656
10LIMK12.21213537
11TESK12.18452308
12SCYL22.13120639
13MAP4K22.12119866
14STK161.86847623
15ZAK1.79843652
16TLK11.61874048
17GRK71.59240478
18VRK11.57170944
19MAP3K121.53101664
20TEC1.51820622
21ADRBK21.50323750
22NUAK11.48264974
23GRK11.29956721
24IKBKE1.27770091
25NME11.22190105
26FES1.21743173
27MAPKAPK31.20402461
28SYK1.19729266
29MUSK1.18520774
30BCR1.15880541
31BUB11.15685995
32DAPK11.13043342
33GRK61.09227251
34TBK11.01749933
35MAP3K110.95064364
36TNK20.94161477
37PRKCQ0.93414711
38CSNK1G30.92042737
39LCK0.89008742
40KIT0.84336314
41CSF1R0.84103220
42BTK0.83390091
43MAPK130.79154583
44IKBKB0.77628892
45LYN0.76325337
46INSRR0.74780783
47GRK50.71930759
48CSNK1A1L0.71409882
49WNK40.65310737
50ERBB30.64695147
51MAP2K70.62476321
52CDK190.61624588
53RPS6KA50.59862159
54TRIM280.59696475
55STK100.59066379
56MYLK0.57631585
57RPS6KA40.57086567
58ZAP700.56788893
59OBSCN0.56537620
60PASK0.55092852
61OXSR10.54484018
62CSK0.54321645
63CSNK1G20.54061411
64WNK30.52660332
65CSNK1G10.52619901
66IGF1R0.52311997
67EPHA40.51787049
68MST40.44898951
69MAP3K50.40878737
70EIF2AK30.40220171
71PIM10.38295500
72JAK30.38028877
73AURKA0.37962513
74PINK10.37386761
75BMPR20.37091456
76FYN0.36718475
77PIK3CA0.36458920
78PHKG20.35701220
79PHKG10.35701220
80TGFBR20.34942468
81ADRBK10.34805328
82STK390.33481256
83PRKCA0.31497770
84MAP2K60.30791153
85MAP3K40.30209393
86ROCK10.29755814
87DAPK20.29734953
88MAPKAPK50.29328404
89ATR0.28016670
90FRK0.27991216
91CSNK1A10.26763994
92PAK10.26759977
93MAPKAPK20.26327983
94PLK40.26276009
95PRKCD0.26104918
96CSNK2A10.25811998
97PRKCH0.25183421
98BMPR1B0.22995453
99ABL10.22822422
100CAMK2A0.22401561

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.12769074
2Proteasome_Homo sapiens_hsa030504.41634552
3Oxidative phosphorylation_Homo sapiens_hsa001903.27052784
4Antigen processing and presentation_Homo sapiens_hsa046123.03725109
5Graft-versus-host disease_Homo sapiens_hsa053322.78534288
6Parkinsons disease_Homo sapiens_hsa050122.56454199
7Autoimmune thyroid disease_Homo sapiens_hsa053202.51296988
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.42017566
9Allograft rejection_Homo sapiens_hsa053302.37944242
10Protein export_Homo sapiens_hsa030602.15764673
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.14923734
12Hematopoietic cell lineage_Homo sapiens_hsa046402.02239110
13Phototransduction_Homo sapiens_hsa047442.00963796
14RNA polymerase_Homo sapiens_hsa030201.94515144
15Type I diabetes mellitus_Homo sapiens_hsa049401.85532234
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.81992907
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.80559802
18Alzheimers disease_Homo sapiens_hsa050101.70122502
19Rheumatoid arthritis_Homo sapiens_hsa053231.69052584
20T cell receptor signaling pathway_Homo sapiens_hsa046601.67460461
21Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.60758349
22Huntingtons disease_Homo sapiens_hsa050161.47473833
23Ribosome_Homo sapiens_hsa030101.30808115
24Caffeine metabolism_Homo sapiens_hsa002321.24756211
25Asthma_Homo sapiens_hsa053101.23930258
26Cardiac muscle contraction_Homo sapiens_hsa042601.23505722
27DNA replication_Homo sapiens_hsa030301.23078142
28Pyrimidine metabolism_Homo sapiens_hsa002401.21554657
29Nitrogen metabolism_Homo sapiens_hsa009101.20978521
30One carbon pool by folate_Homo sapiens_hsa006701.18504308
31Shigellosis_Homo sapiens_hsa051311.15635467
32NF-kappa B signaling pathway_Homo sapiens_hsa040641.15137558
33Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.13892324
34Linoleic acid metabolism_Homo sapiens_hsa005911.12222624
35Homologous recombination_Homo sapiens_hsa034401.08752204
36Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.08621167
37Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.07927337
38Viral myocarditis_Homo sapiens_hsa054161.06679132
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.00559110
40Measles_Homo sapiens_hsa051620.99565573
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99227166
42Base excision repair_Homo sapiens_hsa034100.98618258
43Purine metabolism_Homo sapiens_hsa002300.96754947
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.96607798
45Systemic lupus erythematosus_Homo sapiens_hsa053220.93836084
46Fanconi anemia pathway_Homo sapiens_hsa034600.91852049
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91001210
48RNA degradation_Homo sapiens_hsa030180.86545071
49Salmonella infection_Homo sapiens_hsa051320.82444817
50Peroxisome_Homo sapiens_hsa041460.81769176
51Tryptophan metabolism_Homo sapiens_hsa003800.81433353
52Collecting duct acid secretion_Homo sapiens_hsa049660.79716552
53Nucleotide excision repair_Homo sapiens_hsa034200.77645769
54Steroid hormone biosynthesis_Homo sapiens_hsa001400.72098250
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.71498868
56Malaria_Homo sapiens_hsa051440.70492818
57Mismatch repair_Homo sapiens_hsa034300.68940930
58Arachidonic acid metabolism_Homo sapiens_hsa005900.67295669
59Propanoate metabolism_Homo sapiens_hsa006400.66397502
60Taste transduction_Homo sapiens_hsa047420.62835208
61Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.60639235
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59609738
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59551841
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59415826
65Butanoate metabolism_Homo sapiens_hsa006500.57012678
66Chemical carcinogenesis_Homo sapiens_hsa052040.56455724
67Olfactory transduction_Homo sapiens_hsa047400.55017952
68Ether lipid metabolism_Homo sapiens_hsa005650.50771957
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48426105
70Retinol metabolism_Homo sapiens_hsa008300.46798919
71Spliceosome_Homo sapiens_hsa030400.46740991
72Selenocompound metabolism_Homo sapiens_hsa004500.46597422
73Epstein-Barr virus infection_Homo sapiens_hsa051690.45333917
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44523410
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44381509
76Fatty acid elongation_Homo sapiens_hsa000620.43177640
77Metabolic pathways_Homo sapiens_hsa011000.43133934
78Maturity onset diabetes of the young_Homo sapiens_hsa049500.40857158
79Herpes simplex infection_Homo sapiens_hsa051680.39518896
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38042650
81Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.33699556
82Staphylococcus aureus infection_Homo sapiens_hsa051500.33299687
83NOD-like receptor signaling pathway_Homo sapiens_hsa046210.32907517
84Regulation of autophagy_Homo sapiens_hsa041400.32084552
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.30116841
86Glutathione metabolism_Homo sapiens_hsa004800.29673941
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.29127298
88N-Glycan biosynthesis_Homo sapiens_hsa005100.28519952
89Salivary secretion_Homo sapiens_hsa049700.28399221
90Nicotine addiction_Homo sapiens_hsa050330.27954616
91Morphine addiction_Homo sapiens_hsa050320.27334440
92Sulfur relay system_Homo sapiens_hsa041220.26406896
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.26315131
94RNA transport_Homo sapiens_hsa030130.25634577
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.23511038
96Primary bile acid biosynthesis_Homo sapiens_hsa001200.23191573
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.22256719
98Legionellosis_Homo sapiens_hsa051340.21123742
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.20299767
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.19785484

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