HNRNPH1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450917.59614350
2regulation of memory T cell differentiation (GO:0043380)6.92744454
3cellular response to interleukin-15 (GO:0071350)6.64522806
4cytidine metabolic process (GO:0046087)6.48486257
5cytidine catabolic process (GO:0006216)6.48486257
6cytidine deamination (GO:0009972)6.48486257
7pyrimidine ribonucleoside catabolic process (GO:0046133)6.05958344
8DNA deamination (GO:0045006)5.50788050
9regulation of activation of Janus kinase activity (GO:0010533)5.44862726
10positive regulation of defense response to virus by host (GO:0002230)5.30173950
11response to interleukin-15 (GO:0070672)5.17533494
12positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.14044023
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.04987198
14negative regulation of cell killing (GO:0031342)5.04987198
15regulation of regulatory T cell differentiation (GO:0045589)4.82482193
16positive regulation of T cell differentiation in thymus (GO:0033089)4.79252942
17regulation of interleukin-12 biosynthetic process (GO:0045075)4.51277445
18negative regulation by host of viral transcription (GO:0043922)4.30364591
19negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)4.18359953
20regulation of T cell mediated cytotoxicity (GO:0001914)3.95245579
21regulation of cilium movement (GO:0003352)3.88881443
22negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.77644021
23negative regulation of T-helper cell differentiation (GO:0045623)3.77644021
24regulation of T cell receptor signaling pathway (GO:0050856)3.72519713
25positive regulation of T cell mediated cytotoxicity (GO:0001916)3.69657942
26protein polyglutamylation (GO:0018095)3.65878318
27positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.63535303
28regulation of gamma-delta T cell differentiation (GO:0045586)3.63277577
29antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.60550062
30regulation of immunoglobulin secretion (GO:0051023)3.59297690
31positive regulation of gamma-delta T cell activation (GO:0046645)3.53163589
32eosinophil chemotaxis (GO:0048245)3.51690299
33negative T cell selection (GO:0043383)3.50734205
34interferon-gamma production (GO:0032609)3.49516888
35positive regulation of T cell cytokine production (GO:0002726)3.48050506
36granulocyte activation (GO:0036230)3.46527612
37regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.43434288
38sequestering of actin monomers (GO:0042989)3.36615136
39regulation of gamma-delta T cell activation (GO:0046643)3.35290441
40negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.35225511
41neutrophil activation (GO:0042119)3.32392511
42positive regulation of T cell mediated immunity (GO:0002711)3.30604857
43negative regulation of DNA-templated transcription, elongation (GO:0032785)3.30356821
44GPI anchor metabolic process (GO:0006505)3.30119597
45preassembly of GPI anchor in ER membrane (GO:0016254)3.26674258
46mast cell activation (GO:0045576)3.26421673
47positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.25989431
48regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.25545247
49positive regulation of interleukin-12 production (GO:0032735)3.20508347
50regulation of defense response to virus by host (GO:0050691)3.18428629
51eosinophil migration (GO:0072677)3.17076497
52response to gravity (GO:0009629)3.16733874
53regulation of T-helper 1 type immune response (GO:0002825)3.14309787
54regulation of leukocyte mediated cytotoxicity (GO:0001910)3.13048388
55GPI anchor biosynthetic process (GO:0006506)3.11727893
56negative regulation of T cell mediated immunity (GO:0002710)3.10950547
57positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.09823704
58regulation of T cell mediated immunity (GO:0002709)3.07942732
59positive regulation of T-helper cell differentiation (GO:0045624)3.07544959
60regulation of chronic inflammatory response (GO:0002676)3.06057793
61regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.03639945
62positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.03599799
63positive regulation of alpha-beta T cell proliferation (GO:0046641)3.02865671
64positive regulation of activated T cell proliferation (GO:0042104)3.00151036
65DNA demethylation (GO:0080111)2.94262545
66regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.93676822
67CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.91500834
68T-helper cell differentiation (GO:0042093)2.91500834
69regulation of alpha-beta T cell proliferation (GO:0046640)2.91339921
70negative regulation of alpha-beta T cell differentiation (GO:0046639)2.91088406
71negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.87369672
72negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.86310685
73regulation of T-helper 1 cell differentiation (GO:0045625)2.85792256
74negative regulation of viral genome replication (GO:0045071)2.85231409
75positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.85180981
76regulation of cell killing (GO:0031341)2.83272401
77cellular defense response (GO:0006968)2.83079579
78negative regulation of adaptive immune response (GO:0002820)2.81794224
79S-adenosylmethionine metabolic process (GO:0046500)2.80971150
80pyrimidine nucleoside catabolic process (GO:0046135)2.79019498
81positive regulation of interleukin-17 production (GO:0032740)2.77213509
82positive T cell selection (GO:0043368)2.75703348
83growth hormone receptor signaling pathway (GO:0060396)2.74740390
84regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.74357102
85positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.73450535
86regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.73450535
87positive regulation of interleukin-8 secretion (GO:2000484)2.72510034
88regulation of T-helper cell differentiation (GO:0045622)2.71137657
89regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.70348530
90positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.70348530
91positive regulation of granulocyte differentiation (GO:0030854)2.66091602
92CD4-positive, alpha-beta T cell activation (GO:0035710)2.64993890
93positive regulation of T-helper 1 type immune response (GO:0002827)2.64294090
94positive regulation of T cell differentiation (GO:0045582)2.64225351
95detection of light stimulus involved in sensory perception (GO:0050962)2.61997592
96detection of light stimulus involved in visual perception (GO:0050908)2.61997592
97negative regulation of interleukin-10 production (GO:0032693)2.60790222
98cellular ketone body metabolic process (GO:0046950)2.59855385
99regulation of interleukin-17 production (GO:0032660)2.59738317
100positive regulation of oligodendrocyte differentiation (GO:0048714)2.58588344

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.38855854
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.77497894
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.41513624
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.75081682
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.65062552
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.61540688
7RUNX_20019798_ChIP-Seq_JUKART_Human3.27452075
8VDR_22108803_ChIP-Seq_LS180_Human3.00615990
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.74871873
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.67292728
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.08106833
12GATA3_26560356_Chip-Seq_TH2_Human2.05996468
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.05882857
14NOTCH1_21737748_ChIP-Seq_TLL_Human2.03675058
15MYB_26560356_Chip-Seq_TH2_Human1.97352023
16LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.94961685
17STAT4_19710469_ChIP-ChIP_TH1__Mouse1.88729826
18FLI1_27457419_Chip-Seq_LIVER_Mouse1.87944445
19ZNF274_21170338_ChIP-Seq_K562_Hela1.86316875
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.86083974
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.82545830
22GATA3_27048872_Chip-Seq_THYMUS_Human1.78890482
23ELF1_17652178_ChIP-ChIP_JURKAT_Human1.77975966
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.77451889
25TP53_22573176_ChIP-Seq_HFKS_Human1.72287147
26IGF1R_20145208_ChIP-Seq_DFB_Human1.71105692
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.66238930
28CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.54311474
29TAF15_26573619_Chip-Seq_HEK293_Human1.53416548
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53196970
31ER_23166858_ChIP-Seq_MCF-7_Human1.52404180
32LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.48500578
33BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.48375743
34CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.47732411
35AR_21572438_ChIP-Seq_LNCaP_Human1.47392858
36EGR1_23403033_ChIP-Seq_LIVER_Mouse1.47183971
37VDR_23849224_ChIP-Seq_CD4+_Human1.40305829
38SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.37229107
39BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.36555174
40CBP_20019798_ChIP-Seq_JUKART_Human1.34266692
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34266692
42MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.33662111
43MYB_26560356_Chip-Seq_TH1_Human1.29710974
44PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.26002657
45FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.25665327
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.24578785
47NANOG_20526341_ChIP-Seq_ESCs_Human1.18825004
48AR_20517297_ChIP-Seq_VCAP_Human1.17653591
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.17599783
50GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.17140674
51GATA1_22025678_ChIP-Seq_K562_Human1.15458312
52PCGF2_27294783_Chip-Seq_ESCs_Mouse1.14997278
53AUTS2_25519132_ChIP-Seq_293T-REX_Human1.14446833
54FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13822218
55BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.12840789
56TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.11315891
57SRF_21415370_ChIP-Seq_HL-1_Mouse1.10176719
58BCAT_22108803_ChIP-Seq_LS180_Human1.06909915
59PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06842500
60MYC_19829295_ChIP-Seq_ESCs_Human1.06431028
61RXR_22108803_ChIP-Seq_LS180_Human1.05819965
62IRF8_27001747_Chip-Seq_BMDM_Mouse1.05538897
63ESR1_21235772_ChIP-Seq_MCF-7_Human1.05386556
64RUNX1_22412390_ChIP-Seq_EML_Mouse1.04922773
65SCL_19346495_ChIP-Seq_HPC-7_Human1.04477075
66MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.04285367
67GATA3_21878914_ChIP-Seq_MCF-7_Human1.04084080
68HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.04009448
69GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.03941683
70RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.03534501
71UTX_26944678_Chip-Seq_JUKART_Human1.02695545
72SPI1_23547873_ChIP-Seq_NB4_Human1.02607068
73E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.02345778
74EWS_26573619_Chip-Seq_HEK293_Human1.01545080
75SOX2_19829295_ChIP-Seq_ESCs_Human1.01301169
76NANOG_19829295_ChIP-Seq_ESCs_Human1.01301169
77CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00931845
78GATA2_21666600_ChIP-Seq_HMVEC_Human1.00715073
79SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99944807
80GABP_17652178_ChIP-ChIP_JURKAT_Human0.98853705
81GBX2_23144817_ChIP-Seq_PC3_Human0.98559066
82GATA3_26560356_Chip-Seq_TH1_Human0.97098773
83FOXP3_21729870_ChIP-Seq_TREG_Human0.96280263
84NFE2_27457419_Chip-Seq_LIVER_Mouse0.95896907
85TAF2_19829295_ChIP-Seq_ESCs_Human0.95487955
86STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.95316833
87OCT4_20526341_ChIP-Seq_ESCs_Human0.95098411
88FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.94904836
89FOXA1_27270436_Chip-Seq_PROSTATE_Human0.93945926
90FOXA1_25329375_ChIP-Seq_VCAP_Human0.93945926
91TCF4_22108803_ChIP-Seq_LS180_Human0.93343644
92CTBP1_25329375_ChIP-Seq_LNCAP_Human0.91865046
93P300_19829295_ChIP-Seq_ESCs_Human0.91826248
94FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.91465135
95HOXB7_26014856_ChIP-Seq_BT474_Human0.91445914
96PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.91283631
97RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90725394
98P300_27268052_Chip-Seq_Bcells_Human0.89942423
99PRDM14_20953172_ChIP-Seq_ESCs_Human0.86910578
100EZH2_27294783_Chip-Seq_NPCs_Mouse0.85760302

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.42554549
2MP0003724_increased_susceptibility_to3.81570187
3MP0009785_altered_susceptibility_to3.10287025
4MP0005000_abnormal_immune_tolerance2.94238232
5MP0001835_abnormal_antigen_presentation2.88248572
6MP0002148_abnormal_hypersensitivity_rea2.76598061
7MP0002723_abnormal_immune_serum2.64973593
8MP0001800_abnormal_humoral_immune2.42424898
9MP0003436_decreased_susceptibility_to2.34291618
10MP0001819_abnormal_immune_cell2.26397734
11MP0002420_abnormal_adaptive_immunity2.25441484
12MP0003866_abnormal_defecation2.21541116
13MP0000569_abnormal_digit_pigmentation2.20118417
14MP0004381_abnormal_hair_follicle2.12309936
15MP0002452_abnormal_antigen_presenting2.11764886
16MP0005174_abnormal_tail_pigmentation2.11057256
17MP0003195_calcinosis2.09205001
18MP0000372_irregular_coat_pigmentation2.02950712
19MP0000465_gastrointestinal_hemorrhage2.00683779
20MP0003878_abnormal_ear_physiology1.95645756
21MP0005377_hearing/vestibular/ear_phenot1.95645756
22MP0005025_abnormal_response_to1.94834761
23MP0003763_abnormal_thymus_physiology1.81121174
24MP0004947_skin_inflammation1.80614919
25MP0006082_CNS_inflammation1.76617312
26MP0002398_abnormal_bone_marrow1.74836071
27MP0002419_abnormal_innate_immunity1.73869880
28MP0001501_abnormal_sleep_pattern1.73722781
29MP0005167_abnormal_blood-brain_barrier1.71946798
30MP0010155_abnormal_intestine_physiology1.71724381
31MP0000716_abnormal_immune_system1.70721307
32MP0008877_abnormal_DNA_methylation1.66799043
33MP0002166_altered_tumor_susceptibility1.59377543
34MP0003045_fibrosis1.54903411
35MP0005387_immune_system_phenotype1.53957976
36MP0001790_abnormal_immune_system1.53957976
37MP0005367_renal/urinary_system_phenotyp1.53583010
38MP0000516_abnormal_urinary_system1.53583010
39MP0009764_decreased_sensitivity_to1.52291019
40MP0009765_abnormal_xenobiotic_induced1.51641743
41MP0001765_abnormal_ion_homeostasis1.51373544
42MP0010368_abnormal_lymphatic_system1.50569599
43MP0001533_abnormal_skeleton_physiology1.50539118
44MP0004885_abnormal_endolymph1.49268684
45MP0000685_abnormal_immune_system1.47427918
46MP0002277_abnormal_respiratory_mucosa1.46430284
47MP0002876_abnormal_thyroid_physiology1.42605054
48MP0010329_abnormal_lipoprotein_level1.37813617
49MP0009333_abnormal_splenocyte_physiolog1.35338877
50MP0005253_abnormal_eye_physiology1.33870799
51MP0000015_abnormal_ear_pigmentation1.33560856
52MP0006072_abnormal_retinal_apoptosis1.33507672
53MP0006054_spinal_hemorrhage1.33056273
54MP0008961_abnormal_basal_metabolism1.32552248
55MP0002009_preneoplasia1.29389830
56MP0001984_abnormal_olfaction1.28223408
57MP0002429_abnormal_blood_cell1.28114638
58MP0005084_abnormal_gallbladder_morpholo1.25808661
59MP0000703_abnormal_thymus_morphology1.23450872
60MP0001845_abnormal_inflammatory_respons1.22709753
61MP0002722_abnormal_immune_system1.20702816
62MP0005670_abnormal_white_adipose1.20128892
63MP0004145_abnormal_muscle_electrophysio1.19970021
64MP0000689_abnormal_spleen_morphology1.19601263
65MP0002736_abnormal_nociception_after1.18473677
66MP0002095_abnormal_skin_pigmentation1.17876157
67MP0002006_tumorigenesis1.16302767
68MP0005551_abnormal_eye_electrophysiolog1.13426447
69MP0009763_increased_sensitivity_to1.13346821
70MP0008469_abnormal_protein_level1.12435247
71MP0003646_muscle_fatigue1.06888745
72MP0005075_abnormal_melanosome_morpholog1.05010957
73MP0004130_abnormal_muscle_cell1.01227329
74MP0002127_abnormal_cardiovascular_syste0.96709851
75MP0005310_abnormal_salivary_gland0.95215917
76MP0000427_abnormal_hair_cycle0.94586524
77MP0002405_respiratory_system_inflammati0.94419569
78MP0003252_abnormal_bile_duct0.92213733
79MP0001968_abnormal_touch/_nociception0.90439561
80MP0005360_urolithiasis0.89620701
81MP0002138_abnormal_hepatobiliary_system0.88690065
82MP0005464_abnormal_platelet_physiology0.83505209
83MP0008875_abnormal_xenobiotic_pharmacok0.82304082
84MP0002909_abnormal_adrenal_gland0.80672654
85MP0005448_abnormal_energy_balance0.80220605
86MP0005636_abnormal_mineral_homeostasis0.76628675
87MP0006292_abnormal_olfactory_placode0.72940684
88MP0000537_abnormal_urethra_morphology0.72563214
89MP0002653_abnormal_ependyma_morphology0.71779426
90MP0003300_gastrointestinal_ulcer0.71563646
91MP0005083_abnormal_biliary_tract0.71111375
92MP0001986_abnormal_taste_sensitivity0.69401580
93MP0000249_abnormal_blood_vessel0.69201243
94MP0005085_abnormal_gallbladder_physiolo0.68960546
95MP0001486_abnormal_startle_reflex0.68047413
96MP0003075_altered_response_to0.67412890
97MP0001529_abnormal_vocalization0.67251955
98MP0000371_diluted_coat_color0.66848749
99MP0010307_abnormal_tumor_latency0.64214017
100MP0003279_aneurysm0.63466687

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)6.02733229
2Abnormality of T cell number (HP:0011839)5.25683700
3Methylmalonic acidemia (HP:0002912)5.15123609
4Elevated erythrocyte sedimentation rate (HP:0003565)5.08363204
5Severe combined immunodeficiency (HP:0004430)4.62603042
6Stomatitis (HP:0010280)4.46142072
7Optic neuritis (HP:0100653)4.22296870
8Retrobulbar optic neuritis (HP:0100654)4.22296870
9Myositis (HP:0100614)3.99399562
10Thyroiditis (HP:0100646)3.96467056
11Orchitis (HP:0100796)3.94992243
12IgG deficiency (HP:0004315)3.86244200
13Methylmalonic aciduria (HP:0012120)3.72052362
14Abnormality of eosinophils (HP:0001879)3.48918286
15Combined immunodeficiency (HP:0005387)3.43607824
16Congenital stationary night blindness (HP:0007642)3.41699210
17Abnormality of T cells (HP:0002843)3.35307547
18Abnormality of the vitamin B12 metabolism (HP:0004341)3.20906880
19Abnormality of vitamin B metabolism (HP:0004340)2.99973398
20Leukocytosis (HP:0001974)2.93353578
21Aplastic anemia (HP:0001915)2.76187385
22Keratoconjunctivitis sicca (HP:0001097)2.59052023
23Keratoconjunctivitis (HP:0001096)2.54146248
24Congenital, generalized hypertrichosis (HP:0004540)2.45391045
25Arterial thrombosis (HP:0004420)2.41496046
26Chronic diarrhea (HP:0002028)2.35444600
27Gangrene (HP:0100758)2.32668133
28Episodic fever (HP:0001954)2.32372002
29Abnormality of the pleura (HP:0002103)2.30404760
30Recurrent fungal infections (HP:0002841)2.29632049
31Gastrointestinal infarctions (HP:0005244)2.28963310
32Recurrent bronchitis (HP:0002837)2.28277217
33Agitation (HP:0000713)2.28181516
34Pustule (HP:0200039)2.27899403
35Eosinophilia (HP:0001880)2.26900378
36Short tibia (HP:0005736)2.26622288
37Aplasia/Hypoplasia of the tibia (HP:0005772)2.26072494
38Arthropathy (HP:0003040)2.23364858
39Joint swelling (HP:0001386)2.18603707
40Encephalitis (HP:0002383)2.11489189
41Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.05252666
42Hypoproteinemia (HP:0003075)2.05241664
43Ketosis (HP:0001946)2.04820116
44Oral leukoplakia (HP:0002745)2.02194713
45Abnormal number of erythroid precursors (HP:0012131)2.01898348
46Duplicated collecting system (HP:0000081)2.00390966
47Stomach cancer (HP:0012126)2.00236564
48Medial flaring of the eyebrow (HP:0010747)2.00026550
49Renal cortical cysts (HP:0000803)1.98035355
50Abnormality of the renal collecting system (HP:0004742)1.96533323
51B lymphocytopenia (HP:0010976)1.92339967
52Parakeratosis (HP:0001036)1.90807098
53Anhidrosis (HP:0000970)1.90446820
54Abnormality of vitamin metabolism (HP:0100508)1.90162930
55Granulocytopenia (HP:0001913)1.89883094
56Decreased central vision (HP:0007663)1.88753714
57Failure to thrive in infancy (HP:0001531)1.88465741
58Rib fusion (HP:0000902)1.87893141
59Hemiparesis (HP:0001269)1.86739343
60IgM deficiency (HP:0002850)1.86628566
61Cutaneous melanoma (HP:0012056)1.85853363
62Albinism (HP:0001022)1.85666807
63Vasculitis (HP:0002633)1.85483147
64Neutropenia (HP:0001875)1.85191505
65Abnormality of binocular vision (HP:0011514)1.84485733
66Diplopia (HP:0000651)1.84485733
67Genetic anticipation (HP:0003743)1.84255231
68Keratitis (HP:0000491)1.84143665
69Attenuation of retinal blood vessels (HP:0007843)1.83240622
70Hemoptysis (HP:0002105)1.82908789
71Bronchitis (HP:0012387)1.81463269
72Vertigo (HP:0002321)1.81347126
73Abnormality of B cell number (HP:0010975)1.80938582
74Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.79311480
75Autoimmune hemolytic anemia (HP:0001890)1.78362265
76Pancreatic cysts (HP:0001737)1.77770035
77Anorexia (HP:0002039)1.74668990
78Pulmonary embolism (HP:0002204)1.74394367
79Abnormality of dicarboxylic acid metabolism (HP:0010995)1.74355066
80Dicarboxylic aciduria (HP:0003215)1.74355066
81Conical tooth (HP:0000698)1.73783694
82Pulmonary infiltrates (HP:0002113)1.70667888
83Pruritus (HP:0000989)1.69922447
84Ketoacidosis (HP:0001993)1.69252556
85Abnormality of the fovea (HP:0000493)1.68955049
86Neoplasm of the heart (HP:0100544)1.68805751
87Colitis (HP:0002583)1.68187561
88Spontaneous abortion (HP:0005268)1.67161696
89Adactyly (HP:0009776)1.66445373
90Chronic mucocutaneous candidiasis (HP:0002728)1.65400804
91Recurrent cutaneous fungal infections (HP:0011370)1.65400804
92Abnormality of dental color (HP:0011073)1.64683935
93Aplasia/Hypoplasia of the fovea (HP:0008060)1.64234677
94Hypoplasia of the fovea (HP:0007750)1.64234677
95Anal stenosis (HP:0002025)1.62430870
96Gingival bleeding (HP:0000225)1.60892334
97Abnormality of the endocardium (HP:0004306)1.60854617
98Large for gestational age (HP:0001520)1.60727335
99Hemorrhage of the eye (HP:0011885)1.60398675
100Abnormality of macrophages (HP:0004311)1.60233285

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K25.80754030
2EPHA34.41990679
3TXK4.16144417
4TLK13.88549232
5TESK22.64282270
6MAP4K12.40455281
7KDR2.17048228
8GRK62.06446724
9EPHB21.93949521
10DAPK21.92193483
11IRAK11.87400312
12IKBKB1.86605195
13PINK11.71473074
14MAP3K141.66795734
15FES1.59649751
16ITK1.58015507
17BCKDK1.57307085
18IKBKE1.53937980
19EPHB11.52769607
20JAK11.52489409
21ADRBK21.49560369
22BMPR21.49204747
23FRK1.48304505
24TBK11.43285338
25PIK3CA1.42105520
26GRK11.40048031
27SYK1.28971991
28INSRR1.23333287
29FGFR31.22311965
30MAP3K61.21307776
31CHUK1.20678864
32MATK1.20444721
33MAPK151.14689241
34NUAK11.04607539
35OXSR11.03744653
36LCK1.02091787
37MAP2K21.01070113
38KIT1.00655397
39TEC0.95805372
40NLK0.95415363
41CSK0.95089352
42MAP3K130.95056113
43GRK70.92894408
44SIK30.91673057
45WNK40.84621080
46RIPK40.81628179
47MST40.80692820
48LYN0.80229843
49IRAK40.79993856
50PRKCQ0.75603956
51PASK0.73907465
52FGFR40.73134986
53HCK0.72997153
54ERBB20.72364946
55ZAP700.72329131
56MAP2K60.72049003
57CLK10.71241182
58GRK50.69640521
59MARK30.69287886
60SIK20.64114717
61MAP3K40.61143091
62ZAK0.60779525
63ARAF0.60175007
64BTK0.59428967
65TNK20.57052255
66JAK20.54549093
67RPS6KA50.53630135
68BUB10.52807379
69RAF10.52680930
70TRIM280.48273595
71BLK0.47911655
72MAPK130.45898174
73WEE10.44605259
74JAK30.43847764
75TAOK10.43201761
76TAOK30.42310930
77WNK30.41802130
78MAPK70.40686821
79STK100.39642106
80MOS0.36600616
81PIK3CG0.35910318
82PIM20.35336683
83DAPK10.34778117
84CDK120.34376012
85NME10.34201974
86MAPKAPK20.33851522
87IGF1R0.32506284
88PRKCE0.31301689
89PAK30.28639075
90ADRBK10.28397154
91MAPK30.27359527
92PIM10.26441544
93RET0.26262169
94DYRK30.25870549
95MAP3K120.25573337
96KSR10.25073062
97TRPM70.24754753
98DYRK1A0.24071467
99INSR0.23770115
100RPS6KA60.23691494

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.68940219
2Primary immunodeficiency_Homo sapiens_hsa053403.48043700
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.24608657
4Graft-versus-host disease_Homo sapiens_hsa053323.09647115
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.71643009
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.60595950
7Antigen processing and presentation_Homo sapiens_hsa046122.41612672
8Allograft rejection_Homo sapiens_hsa053302.36682638
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.35157558
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.33700907
11Type I diabetes mellitus_Homo sapiens_hsa049402.32452453
12Autoimmune thyroid disease_Homo sapiens_hsa053202.15029137
13NOD-like receptor signaling pathway_Homo sapiens_hsa046212.09029783
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.94456678
15Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.91872961
16T cell receptor signaling pathway_Homo sapiens_hsa046601.91460891
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.90755996
18Propanoate metabolism_Homo sapiens_hsa006401.77993593
19Circadian rhythm_Homo sapiens_hsa047101.75401512
20Asthma_Homo sapiens_hsa053101.67122884
21Rheumatoid arthritis_Homo sapiens_hsa053231.61170979
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.60815461
23Butanoate metabolism_Homo sapiens_hsa006501.57498832
24Hematopoietic cell lineage_Homo sapiens_hsa046401.45883274
25Leishmaniasis_Homo sapiens_hsa051401.43766401
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.42729098
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.31678388
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.30692118
29SNARE interactions in vesicular transport_Homo sapiens_hsa041301.27288642
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.26554326
31Caffeine metabolism_Homo sapiens_hsa002321.26539308
32Measles_Homo sapiens_hsa051621.25071095
33Primary bile acid biosynthesis_Homo sapiens_hsa001201.22704340
34Staphylococcus aureus infection_Homo sapiens_hsa051501.21426718
35Malaria_Homo sapiens_hsa051441.19332350
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.18855753
37Linoleic acid metabolism_Homo sapiens_hsa005911.16361568
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.12960614
39Taste transduction_Homo sapiens_hsa047421.10289526
40Adipocytokine signaling pathway_Homo sapiens_hsa049201.08565111
41Peroxisome_Homo sapiens_hsa041461.06476016
42Legionellosis_Homo sapiens_hsa051341.04302600
43Osteoclast differentiation_Homo sapiens_hsa043801.03045163
44RNA polymerase_Homo sapiens_hsa030201.03020821
45TNF signaling pathway_Homo sapiens_hsa046681.01932721
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95630283
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91906713
48Herpes simplex infection_Homo sapiens_hsa051680.89938283
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88182697
50Pertussis_Homo sapiens_hsa051330.82318899
51Phototransduction_Homo sapiens_hsa047440.81510937
52Oxidative phosphorylation_Homo sapiens_hsa001900.81417735
53Protein export_Homo sapiens_hsa030600.80735694
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.78372885
55Arachidonic acid metabolism_Homo sapiens_hsa005900.75499382
56Tuberculosis_Homo sapiens_hsa051520.73355419
57B cell receptor signaling pathway_Homo sapiens_hsa046620.70741250
58Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.69882093
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68995434
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67053523
61Chemokine signaling pathway_Homo sapiens_hsa040620.67007988
62Nitrogen metabolism_Homo sapiens_hsa009100.66615314
63Regulation of autophagy_Homo sapiens_hsa041400.62639177
64Salmonella infection_Homo sapiens_hsa051320.62597013
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61691802
66Glycosaminoglycan degradation_Homo sapiens_hsa005310.57813733
67African trypanosomiasis_Homo sapiens_hsa051430.57191980
68Influenza A_Homo sapiens_hsa051640.57176981
69Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.56142039
70ABC transporters_Homo sapiens_hsa020100.55735410
71Chemical carcinogenesis_Homo sapiens_hsa052040.54614961
72Homologous recombination_Homo sapiens_hsa034400.54081685
73Toxoplasmosis_Homo sapiens_hsa051450.51737144
74Tryptophan metabolism_Homo sapiens_hsa003800.49860254
75Sulfur relay system_Homo sapiens_hsa041220.48894179
76Morphine addiction_Homo sapiens_hsa050320.46892859
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46572886
78Olfactory transduction_Homo sapiens_hsa047400.44403691
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.38314671
80Fanconi anemia pathway_Homo sapiens_hsa034600.36052608
81Insulin resistance_Homo sapiens_hsa049310.34005039
82Retinol metabolism_Homo sapiens_hsa008300.32104954
83Complement and coagulation cascades_Homo sapiens_hsa046100.31630620
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.30708054
85Viral myocarditis_Homo sapiens_hsa054160.30084257
86Shigellosis_Homo sapiens_hsa051310.29932683
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.29777520
88Dorso-ventral axis formation_Homo sapiens_hsa043200.29704945
89Apoptosis_Homo sapiens_hsa042100.27768898
90Systemic lupus erythematosus_Homo sapiens_hsa053220.26683155
91Renin secretion_Homo sapiens_hsa049240.25687226
92Fatty acid metabolism_Homo sapiens_hsa012120.24617974
93Epstein-Barr virus infection_Homo sapiens_hsa051690.24325015
94Parkinsons disease_Homo sapiens_hsa050120.22881220
95Vitamin digestion and absorption_Homo sapiens_hsa049770.22487606
96cAMP signaling pathway_Homo sapiens_hsa040240.21855313
97Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.19702134
98Nicotine addiction_Homo sapiens_hsa050330.19286847
99Prolactin signaling pathway_Homo sapiens_hsa049170.18858139
100Acute myeloid leukemia_Homo sapiens_hsa052210.17259060

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