HNRNPCP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.86239218
2tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)5.85931414
3RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)5.85931414
4proteasome assembly (GO:0043248)4.56586430
5respiratory chain complex IV assembly (GO:0008535)4.00579817
6water-soluble vitamin biosynthetic process (GO:0042364)3.93532575
7rRNA modification (GO:0000154)3.89953609
8cullin deneddylation (GO:0010388)3.85494248
9regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.84501234
10mitochondrial respiratory chain complex I assembly (GO:0032981)3.82018746
11NADH dehydrogenase complex assembly (GO:0010257)3.82018746
12mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.82018746
13mitochondrial RNA metabolic process (GO:0000959)3.79968694
14platelet dense granule organization (GO:0060155)3.68849204
15energy coupled proton transport, down electrochemical gradient (GO:0015985)3.63359360
16ATP synthesis coupled proton transport (GO:0015986)3.63359360
17protein deneddylation (GO:0000338)3.58569940
18L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.58326002
19protein complex biogenesis (GO:0070271)3.53790787
20mitochondrial respiratory chain complex assembly (GO:0033108)3.51397634
21folic acid-containing compound biosynthetic process (GO:0009396)3.48689780
22mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.47951763
23behavioral response to nicotine (GO:0035095)3.44838344
24adenosine metabolic process (GO:0046085)3.43496443
25preassembly of GPI anchor in ER membrane (GO:0016254)3.43276109
26protein-cofactor linkage (GO:0018065)3.36652311
27rRNA methylation (GO:0031167)3.34903070
28nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.33884037
29regulation of cellular amino acid metabolic process (GO:0006521)3.32624386
30tRNA processing (GO:0008033)3.28253280
31exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.26342649
32amino acid salvage (GO:0043102)3.24530296
33L-methionine salvage (GO:0071267)3.24530296
34L-methionine biosynthetic process (GO:0071265)3.24530296
35DNA catabolic process, exonucleolytic (GO:0000738)3.19418806
36protein neddylation (GO:0045116)3.18893588
37tRNA modification (GO:0006400)3.18331593
38pseudouridine synthesis (GO:0001522)3.16884969
39L-fucose catabolic process (GO:0042355)3.09010524
40fucose catabolic process (GO:0019317)3.09010524
41L-fucose metabolic process (GO:0042354)3.09010524
42negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.08033409
43IMP biosynthetic process (GO:0006188)3.04351217
44chaperone-mediated protein transport (GO:0072321)3.02268434
45DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.00584690
46cytochrome complex assembly (GO:0017004)2.99850562
47cytidine deamination (GO:0009972)2.97122443
48cytidine metabolic process (GO:0046087)2.97122443
49cytidine catabolic process (GO:0006216)2.97122443
50signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.96546479
51signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.96546479
52signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.96546479
53regulation of isotype switching to IgG isotypes (GO:0048302)2.95816910
54cellular ketone body metabolic process (GO:0046950)2.94777862
55tRNA metabolic process (GO:0006399)2.94032139
56RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.92357701
57regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.90972911
58regulation of mitotic spindle checkpoint (GO:1903504)2.90972911
59mannosylation (GO:0097502)2.90696389
60piRNA metabolic process (GO:0034587)2.89924337
61positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.89682618
62termination of RNA polymerase III transcription (GO:0006386)2.89578625
63transcription elongation from RNA polymerase III promoter (GO:0006385)2.89578625
64signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.89401399
65intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.89401399
66mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.89104919
67kynurenine metabolic process (GO:0070189)2.82343048
68GPI anchor metabolic process (GO:0006505)2.79008760
69signal transduction involved in DNA damage checkpoint (GO:0072422)2.78526023
70signal transduction involved in DNA integrity checkpoint (GO:0072401)2.78526023
71branched-chain amino acid catabolic process (GO:0009083)2.77751315
72positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.77305112
73signal transduction involved in cell cycle checkpoint (GO:0072395)2.75221657
74negative regulation of ligase activity (GO:0051352)2.74879931
75negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.74879931
76DNA double-strand break processing (GO:0000729)2.74531886
77purine nucleotide salvage (GO:0032261)2.74098319
78GPI anchor biosynthetic process (GO:0006506)2.73913658
79protein targeting to mitochondrion (GO:0006626)2.70967876
80positive regulation of defense response to virus by host (GO:0002230)2.67796724
81DNA damage response, detection of DNA damage (GO:0042769)2.67327302
82regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.66432276
83electron transport chain (GO:0022900)2.65963774
84organelle disassembly (GO:1903008)2.63878139
85establishment of protein localization to mitochondrion (GO:0072655)2.63448085
86regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.63330460
87respiratory electron transport chain (GO:0022904)2.63028371
88protein prenylation (GO:0018342)2.62348261
89prenylation (GO:0097354)2.62348261
90protein localization to mitochondrion (GO:0070585)2.61667069
91positive regulation of interleukin-17 production (GO:0032740)2.58754346
92S-adenosylmethionine metabolic process (GO:0046500)2.58664668
93ketone body metabolic process (GO:1902224)2.58604876
94GTP biosynthetic process (GO:0006183)2.58579413
95IMP metabolic process (GO:0046040)2.57158773
96regulation of immunoglobulin secretion (GO:0051023)2.56912121
97regulation of nuclear cell cycle DNA replication (GO:0033262)2.53155144
98methionine biosynthetic process (GO:0009086)2.53134418
99pyrimidine ribonucleoside catabolic process (GO:0046133)2.52278827
100regulation of cilium movement (GO:0003352)2.49822888

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.46139424
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.75805638
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.26978908
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.55856134
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.28377672
6VDR_22108803_ChIP-Seq_LS180_Human3.21028162
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.18219669
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.15885498
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.05601446
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.83619834
11VDR_23849224_ChIP-Seq_CD4+_Human2.79427312
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.73170690
13ZNF274_21170338_ChIP-Seq_K562_Hela2.65373469
14ELK1_19687146_ChIP-ChIP_HELA_Human2.52116236
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.29835736
16SRF_21415370_ChIP-Seq_HL-1_Mouse2.27242642
17FOXP3_21729870_ChIP-Seq_TREG_Human2.24860129
18IRF8_22096565_ChIP-ChIP_GC-B_Human2.20611919
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.19349080
20IGF1R_20145208_ChIP-Seq_DFB_Human2.07270188
21CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.00477617
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.95342598
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.86516935
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.82360576
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.81730477
26PADI4_21655091_ChIP-ChIP_MCF-7_Human1.67239820
27YY1_21170310_ChIP-Seq_MESCs_Mouse1.59669078
28E2F4_17652178_ChIP-ChIP_JURKAT_Human1.57465115
29FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.56572085
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55887380
31MYC_18555785_ChIP-Seq_MESCs_Mouse1.55650183
32CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.53806325
33MYC_18940864_ChIP-ChIP_HL60_Human1.53497110
34TP53_22573176_ChIP-Seq_HFKS_Human1.53291575
35TAF15_26573619_Chip-Seq_HEK293_Human1.50916806
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.50351465
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.49275445
38HOXB4_20404135_ChIP-ChIP_EML_Mouse1.48355869
39MYC_18358816_ChIP-ChIP_MESCs_Mouse1.48203782
40CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.44299538
41IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.44142746
42GATA3_26560356_Chip-Seq_TH2_Human1.42649205
43EWS_26573619_Chip-Seq_HEK293_Human1.39641068
44GABP_19822575_ChIP-Seq_HepG2_Human1.37572729
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.35964979
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32738961
47ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32185484
48ELK1_22589737_ChIP-Seq_MCF10A_Human1.30611774
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28539194
50AR_20517297_ChIP-Seq_VCAP_Human1.27975725
51IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.27037243
52DCP1A_22483619_ChIP-Seq_HELA_Human1.26684768
53EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.23889039
54IRF1_19129219_ChIP-ChIP_H3396_Human1.22637929
55E2F7_22180533_ChIP-Seq_HELA_Human1.22422985
56FOXA1_25329375_ChIP-Seq_VCAP_Human1.21605517
57FOXA1_27270436_Chip-Seq_PROSTATE_Human1.21605517
58SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.18770167
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.18079360
60POU3F2_20337985_ChIP-ChIP_501MEL_Human1.17804654
61MYC_19030024_ChIP-ChIP_MESCs_Mouse1.15134311
62BP1_19119308_ChIP-ChIP_Hs578T_Human1.13343880
63FUS_26573619_Chip-Seq_HEK293_Human1.11399887
64AUTS2_25519132_ChIP-Seq_293T-REX_Human1.10082930
65E2F1_18555785_ChIP-Seq_MESCs_Mouse1.06770753
66PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.06564198
67TTF2_22483619_ChIP-Seq_HELA_Human1.06165174
68NANOG_19829295_ChIP-Seq_ESCs_Human1.05376250
69SOX2_19829295_ChIP-Seq_ESCs_Human1.05376250
70YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04764816
71THAP11_20581084_ChIP-Seq_MESCs_Mouse1.04641626
72CBP_20019798_ChIP-Seq_JUKART_Human1.03385746
73IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03385746
74ER_23166858_ChIP-Seq_MCF-7_Human1.02914725
75CTBP1_25329375_ChIP-Seq_LNCAP_Human1.02363228
76NCOR_22424771_ChIP-Seq_293T_Human1.02111117
77HOXB7_26014856_ChIP-Seq_BT474_Human1.01603373
78MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97996066
79HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.97397350
80MYB_26560356_Chip-Seq_TH2_Human0.97105602
81XRN2_22483619_ChIP-Seq_HELA_Human0.96881978
82SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.96165462
83CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.95902338
84HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.95581377
85ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.94160034
86KLF5_20875108_ChIP-Seq_MESCs_Mouse0.94126988
87PCGF2_27294783_Chip-Seq_NPCs_Mouse0.94051155
88NFE2_27457419_Chip-Seq_LIVER_Mouse0.93936324
89FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93767274
90EGR1_23403033_ChIP-Seq_LIVER_Mouse0.92766617
91GATA3_26560356_Chip-Seq_TH1_Human0.92281535
92TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.92209001
93LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.90158498
94GBX2_23144817_ChIP-Seq_PC3_Human0.89819012
95GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.89270296
96P300_19829295_ChIP-Seq_ESCs_Human0.89054233
97GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88027842
98FOXH1_21741376_ChIP-Seq_EPCs_Human0.87458768
99GATA3_21878914_ChIP-Seq_MCF-7_Human0.87243669
100KDM5A_27292631_Chip-Seq_BREAST_Human0.86283618

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005646_abnormal_pituitary_gland4.20697762
2MP0005645_abnormal_hypothalamus_physiol3.95944223
3MP0004147_increased_porphyrin_level3.88991800
4MP0008877_abnormal_DNA_methylation3.05572166
5MP0002102_abnormal_ear_morphology2.90070476
6MP0006072_abnormal_retinal_apoptosis2.61897544
7MP0003786_premature_aging2.54025377
8MP0008875_abnormal_xenobiotic_pharmacok2.41185091
9MP0003724_increased_susceptibility_to2.23840420
10MP0008995_early_reproductive_senescence2.17252669
11MP0002736_abnormal_nociception_after2.16271806
12MP0008872_abnormal_physiological_respon2.14827937
13MP0005084_abnormal_gallbladder_morpholo2.05749925
14MP0002138_abnormal_hepatobiliary_system2.02800268
15MP0001968_abnormal_touch/_nociception1.89614863
16MP0004885_abnormal_endolymph1.87554266
17MP0003646_muscle_fatigue1.80575943
18MP0008058_abnormal_DNA_repair1.78741613
19MP0005671_abnormal_response_to1.77928543
20MP0003718_maternal_effect1.77777287
21MP0005551_abnormal_eye_electrophysiolog1.75617450
22MP0002148_abnormal_hypersensitivity_rea1.75576737
23MP0010094_abnormal_chromosome_stability1.67215802
24MP0001835_abnormal_antigen_presentation1.67110111
25MP0002006_tumorigenesis1.66560470
26MP0005253_abnormal_eye_physiology1.63169281
27MP0006035_abnormal_mitochondrial_morpho1.57543539
28MP0001984_abnormal_olfaction1.55552593
29MP0001986_abnormal_taste_sensitivity1.51946909
30MP0002837_dystrophic_cardiac_calcinosis1.48797586
31MP0009764_decreased_sensitivity_to1.43965984
32MP0005167_abnormal_blood-brain_barrier1.36306059
33MP0002277_abnormal_respiratory_mucosa1.34037060
34MP0003195_calcinosis1.33791789
35MP0000013_abnormal_adipose_tissue1.33481951
36MP0003693_abnormal_embryo_hatching1.31192956
37MP0006036_abnormal_mitochondrial_physio1.29709208
38MP0002876_abnormal_thyroid_physiology1.26723376
39MP0001661_extended_life_span1.25064177
40MP0001800_abnormal_humoral_immune1.25049444
41MP0005389_reproductive_system_phenotype1.22759665
42MP0001501_abnormal_sleep_pattern1.22686084
43MP0004145_abnormal_muscle_electrophysio1.22037057
44MP0002166_altered_tumor_susceptibility1.21135272
45MP0006292_abnormal_olfactory_placode1.21037519
46MP0001529_abnormal_vocalization1.20904114
47MP0001764_abnormal_homeostasis1.20165888
48MP0002160_abnormal_reproductive_system1.19614645
49MP0003866_abnormal_defecation1.18263534
50MP0001905_abnormal_dopamine_level1.16943395
51MP0002272_abnormal_nervous_system1.13729098
52MP0003186_abnormal_redox_activity1.13179821
53MP0005000_abnormal_immune_tolerance1.12619963
54MP0009333_abnormal_splenocyte_physiolog1.10666560
55MP0002735_abnormal_chemical_nociception1.07828198
56MP0000372_irregular_coat_pigmentation1.07283697
57MP0003806_abnormal_nucleotide_metabolis1.06953549
58MP0009745_abnormal_behavioral_response1.01818253
59MP0006276_abnormal_autonomic_nervous1.01567247
60MP0004043_abnormal_pH_regulation1.00676322
61MP0009785_altered_susceptibility_to1.00619927
62MP0008775_abnormal_heart_ventricle0.96928118
63MP0003011_delayed_dark_adaptation0.96296480
64MP0005332_abnormal_amino_acid0.94628740
65MP0001919_abnormal_reproductive_system0.92404448
66MP0004957_abnormal_blastocyst_morpholog0.92357836
67MP0003878_abnormal_ear_physiology0.91490724
68MP0005377_hearing/vestibular/ear_phenot0.91490724
69MP0004133_heterotaxia0.91041037
70MP0002723_abnormal_immune_serum0.90836482
71MP0001853_heart_inflammation0.90611270
72MP0005360_urolithiasis0.88165487
73MP0002452_abnormal_antigen_presenting0.86519100
74MP0005647_abnormal_sex_gland0.86176427
75MP0000631_abnormal_neuroendocrine_gland0.86174594
76MP0001486_abnormal_startle_reflex0.85428244
77MP0002733_abnormal_thermal_nociception0.83316819
78MP0003763_abnormal_thymus_physiology0.83243513
79MP0000465_gastrointestinal_hemorrhage0.82905146
80MP0000647_abnormal_sebaceous_gland0.79913452
81MP0003252_abnormal_bile_duct0.79496316
82MP0004142_abnormal_muscle_tone0.78017549
83MP0001790_abnormal_immune_system0.77423323
84MP0005387_immune_system_phenotype0.77423323
85MP0005636_abnormal_mineral_homeostasis0.74975797
86MP0000685_abnormal_immune_system0.74938303
87MP0008057_abnormal_DNA_replication0.74523800
88MP0004215_abnormal_myocardial_fiber0.73917847
89MP0009046_muscle_twitch0.73890628
90MP0000689_abnormal_spleen_morphology0.73252874
91MP0001819_abnormal_immune_cell0.72646493
92MP0001243_abnormal_dermal_layer0.71699001
93MP0003787_abnormal_imprinting0.71549267
94MP0005670_abnormal_white_adipose0.70817887
95MP0002420_abnormal_adaptive_immunity0.70496599
96MP0001119_abnormal_female_reproductive0.70258064
97MP0005410_abnormal_fertilization0.69792988
98MP0001845_abnormal_inflammatory_respons0.69006739
99MP0002163_abnormal_gland_morphology0.68514627
100MP0001929_abnormal_gametogenesis0.68462592

Predicted human phenotypes

RankGene SetZ-score
1Hyperalaninemia (HP:0003348)4.22107198
2Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.22107198
3Abnormality of alanine metabolism (HP:0010916)4.22107198
4Acute necrotizing encephalopathy (HP:0006965)3.72160607
5Mitochondrial inheritance (HP:0001427)3.59302975
6Increased CSF lactate (HP:0002490)3.54820691
7Decreased electroretinogram (ERG) amplitude (HP:0000654)3.46293942
8Methylmalonic acidemia (HP:0002912)3.44392018
9Acute encephalopathy (HP:0006846)3.35409777
10Increased hepatocellular lipid droplets (HP:0006565)3.33232456
11Abnormal mitochondria in muscle tissue (HP:0008316)3.30764484
12Lipid accumulation in hepatocytes (HP:0006561)3.29058425
133-Methylglutaconic aciduria (HP:0003535)3.26689244
14Hepatocellular necrosis (HP:0001404)3.15173325
15Elevated erythrocyte sedimentation rate (HP:0003565)3.14544603
16Progressive macrocephaly (HP:0004481)3.03448023
17IgG deficiency (HP:0004315)2.99352248
18Increased serum lactate (HP:0002151)2.99304902
19Renal cortical cysts (HP:0000803)2.98467163
20Hepatic necrosis (HP:0002605)2.96867504
21Methylmalonic aciduria (HP:0012120)2.83302250
22Pancreatic cysts (HP:0001737)2.79300473
23Pendular nystagmus (HP:0012043)2.77586440
24Lactic acidosis (HP:0003128)2.75527901
25Abnormality of serum amino acid levels (HP:0003112)2.67510890
26Tubulointerstitial nephritis (HP:0001970)2.63888185
27Constricted visual fields (HP:0001133)2.60442579
28Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.60124987
29Type 2 muscle fiber atrophy (HP:0003554)2.58136953
30Cerebral edema (HP:0002181)2.57093488
31True hermaphroditism (HP:0010459)2.56398855
32Pancreatic fibrosis (HP:0100732)2.55719731
33Opisthotonus (HP:0002179)2.54282924
34Nephronophthisis (HP:0000090)2.49665602
35Abnormality of the renal cortex (HP:0011035)2.44821110
36Progressive microcephaly (HP:0000253)2.44781255
37Molar tooth sign on MRI (HP:0002419)2.41095906
38Abnormality of midbrain morphology (HP:0002418)2.41095906
39Attenuation of retinal blood vessels (HP:0007843)2.36697099
40Type II lissencephaly (HP:0007260)2.33059787
41Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.27113330
42Type I transferrin isoform profile (HP:0003642)2.26648131
43Medial flaring of the eyebrow (HP:0010747)2.25669561
44Dicarboxylic aciduria (HP:0003215)2.23642068
45Abnormality of dicarboxylic acid metabolism (HP:0010995)2.23642068
46Abolished electroretinogram (ERG) (HP:0000550)2.23342428
47Chronic hepatic failure (HP:0100626)2.21469950
48Abnormality of aspartate family amino acid metabolism (HP:0010899)2.20738146
49Abnormality of the pons (HP:0007361)2.18868205
50Renal Fanconi syndrome (HP:0001994)2.17884095
51Abnormality of the renal medulla (HP:0100957)2.17189772
52Congenital stationary night blindness (HP:0007642)2.17189632
53Respiratory failure (HP:0002878)2.17104911
54Decreased central vision (HP:0007663)2.14020361
55Hyperglycinemia (HP:0002154)2.13462152
56Increased intramyocellular lipid droplets (HP:0012240)2.12547574
57Lethargy (HP:0001254)2.12404563
58Nausea (HP:0002018)2.10918552
59Increased corneal curvature (HP:0100692)2.10529255
60Keratoconus (HP:0000563)2.10529255
61Stomatitis (HP:0010280)2.08161640
62Inability to walk (HP:0002540)2.07081785
63Abnormal biliary tract physiology (HP:0012439)2.05996202
64Bile duct proliferation (HP:0001408)2.05996202
65Metabolic acidosis (HP:0001942)2.05561855
66Muscle fiber atrophy (HP:0100295)2.04676586
67Delayed CNS myelination (HP:0002188)2.03971968
68Abnormality of the vitamin B12 metabolism (HP:0004341)2.03524236
69Optic disc pallor (HP:0000543)2.03429633
70Exercise intolerance (HP:0003546)2.01089010
71Duplicated collecting system (HP:0000081)1.97633898
72Abnormality of homocysteine metabolism (HP:0010919)1.97029418
73Homocystinuria (HP:0002156)1.97029418
74Exertional dyspnea (HP:0002875)1.96134831
75Cerebral palsy (HP:0100021)1.95848498
76Congenital, generalized hypertrichosis (HP:0004540)1.94834167
77Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.94587008
78Abnormal protein N-linked glycosylation (HP:0012347)1.94587008
79Abnormal protein glycosylation (HP:0012346)1.94587008
80Abnormal glycosylation (HP:0012345)1.94587008
81Hypoplasia of the pons (HP:0012110)1.91852534
82Abnormality of the renal collecting system (HP:0004742)1.90618676
83Abnormality of vitamin B metabolism (HP:0004340)1.89947767
84Microvesicular hepatic steatosis (HP:0001414)1.89655400
85Glycosuria (HP:0003076)1.88670404
86Abnormality of urine glucose concentration (HP:0011016)1.88670404
87Increased serum pyruvate (HP:0003542)1.87649892
88Stomach cancer (HP:0012126)1.87019526
89Abnormality of the anterior horn cell (HP:0006802)1.86006649
90Degeneration of anterior horn cells (HP:0002398)1.86006649
91Carpal bone hypoplasia (HP:0001498)1.85369926
92Panhypogammaglobulinemia (HP:0003139)1.83588033
93Absent rod-and cone-mediated responses on ERG (HP:0007688)1.83189740
94Increased muscle lipid content (HP:0009058)1.82443384
95Anorexia (HP:0002039)1.78585705
96Reduced antithrombin III activity (HP:0001976)1.77713016
97Abnormality of glycine metabolism (HP:0010895)1.77399135
98Abnormality of serine family amino acid metabolism (HP:0010894)1.77399135
99Testicular atrophy (HP:0000029)1.76716489
100Colon cancer (HP:0003003)1.75330307

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK3.65380430
2TLK13.33317190
3ADRBK22.84184359
4EIF2AK32.78654541
5TXK2.72590276
6NUAK12.46165831
7TAOK32.43665067
8BUB12.34421944
9VRK22.26912908
10TIE12.22603135
11MAP4K22.18512132
12TSSK62.12782602
13NEK11.69895378
14GRK11.69883488
15SRPK11.69757195
16MST41.67550075
17WNK41.56743909
18VRK11.56473131
19KDR1.48299715
20BCKDK1.44185726
21TEC1.43140194
22MKNK11.42532103
23CSNK1G31.42219867
24MAP3K141.36638628
25STK161.28015075
26CSNK1A1L1.26177082
27MAPKAPK51.23927959
28IKBKB1.23501060
29BCR1.22328306
30NME11.22312241
31CCNB11.22168330
32CSNK1G11.21007258
33CSNK1G21.20864579
34PLK31.16322930
35DAPK11.12558084
36EIF2AK21.10476768
37FRK1.10273711
38RPS6KA51.08919041
39WNK31.07892725
40MAP2K71.07252498
41ITK1.06717030
42TESK21.05443861
43PHKG11.03205526
44PHKG21.03205526
45FES1.00876010
46GRK60.99408138
47ERBB30.98671929
48TRIM280.98158081
49EIF2AK10.97287140
50PLK40.96179760
51MAP4K10.94143991
52MAPKAPK30.91134209
53MAP3K40.90088972
54ADRBK10.88873193
55PINK10.87690585
56BMPR20.86714383
57CAMKK20.86533090
58CLK10.84023278
59ATR0.84016094
60BMPR1B0.82773546
61SYK0.82163776
62OXSR10.81702058
63PBK0.76440606
64PLK20.76097304
65PASK0.73875391
66TTK0.68034760
67TBK10.68031687
68MAP2K20.64170112
69PRKCQ0.64089184
70DYRK20.62133306
71STK390.61534158
72OBSCN0.59330022
73INSRR0.56975512
74PDK20.56192853
75ALK0.56016441
76KIT0.55248908
77IKBKE0.54056858
78ACVR1B0.53831566
79TAF10.53052305
80MAPK130.53036543
81PIK3CA0.53013674
82JAK30.51646389
83CSNK1A10.50274904
84AURKB0.50079788
85PLK10.49672959
86BTK0.49568623
87IRAK40.48678801
88PIK3CG0.47654317
89LCK0.45810442
90CAMK2A0.45665671
91CSNK2A10.44908209
92LYN0.43306310
93PRKCE0.42898934
94IGF1R0.40937370
95PRKCG0.40369335
96TNK20.39402087
97CSNK2A20.38614221
98MKNK20.37656741
99CDK80.37519742
100PRKCA0.37314233

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.05897022
2Oxidative phosphorylation_Homo sapiens_hsa001902.77536903
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.43642655
4One carbon pool by folate_Homo sapiens_hsa006702.43537537
5RNA polymerase_Homo sapiens_hsa030202.34871367
6Parkinsons disease_Homo sapiens_hsa050122.33079302
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.30891758
8Homologous recombination_Homo sapiens_hsa034402.11844288
9Mismatch repair_Homo sapiens_hsa034302.00534720
10Asthma_Homo sapiens_hsa053101.90330129
11Protein export_Homo sapiens_hsa030601.90276225
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.87991907
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.72423784
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.69277126
15DNA replication_Homo sapiens_hsa030301.68535765
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.67956492
17RNA degradation_Homo sapiens_hsa030181.64110761
18Primary immunodeficiency_Homo sapiens_hsa053401.62056348
19Spliceosome_Homo sapiens_hsa030401.61207121
20Non-homologous end-joining_Homo sapiens_hsa034501.54579820
21Regulation of autophagy_Homo sapiens_hsa041401.53465778
22Phototransduction_Homo sapiens_hsa047441.48151936
23Basal transcription factors_Homo sapiens_hsa030221.47714701
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.47399321
25Propanoate metabolism_Homo sapiens_hsa006401.45869401
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.44990228
27Allograft rejection_Homo sapiens_hsa053301.42462416
28RNA transport_Homo sapiens_hsa030131.42366939
29Base excision repair_Homo sapiens_hsa034101.40725336
30Fanconi anemia pathway_Homo sapiens_hsa034601.39254526
31Nitrogen metabolism_Homo sapiens_hsa009101.38535712
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.37841998
33Nucleotide excision repair_Homo sapiens_hsa034201.34803983
34Autoimmune thyroid disease_Homo sapiens_hsa053201.34538316
35Peroxisome_Homo sapiens_hsa041461.30927052
36Alzheimers disease_Homo sapiens_hsa050101.30670090
37Huntingtons disease_Homo sapiens_hsa050161.27081978
38Collecting duct acid secretion_Homo sapiens_hsa049661.25989624
39Butanoate metabolism_Homo sapiens_hsa006501.21637195
40Type I diabetes mellitus_Homo sapiens_hsa049401.21302019
41Fatty acid elongation_Homo sapiens_hsa000621.21028401
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.18606715
43Graft-versus-host disease_Homo sapiens_hsa053321.18064805
44Purine metabolism_Homo sapiens_hsa002301.14060434
45Linoleic acid metabolism_Homo sapiens_hsa005911.13909376
46Sulfur metabolism_Homo sapiens_hsa009201.13675562
47Ribosome_Homo sapiens_hsa030101.13638286
48Pyrimidine metabolism_Homo sapiens_hsa002401.12076300
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.11596719
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.08185415
51SNARE interactions in vesicular transport_Homo sapiens_hsa041301.06943661
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.06901749
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.05520368
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.04579998
55Selenocompound metabolism_Homo sapiens_hsa004501.03696556
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.99085862
57Caffeine metabolism_Homo sapiens_hsa002320.99080643
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.93820603
59Antigen processing and presentation_Homo sapiens_hsa046120.92484478
60Tryptophan metabolism_Homo sapiens_hsa003800.92325164
61Maturity onset diabetes of the young_Homo sapiens_hsa049500.92132474
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.90461376
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.87563843
64Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.86611435
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85329633
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84399357
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81767338
68Chemical carcinogenesis_Homo sapiens_hsa052040.79937446
69Rheumatoid arthritis_Homo sapiens_hsa053230.79865527
70Metabolic pathways_Homo sapiens_hsa011000.73483875
71Glutathione metabolism_Homo sapiens_hsa004800.73365797
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71655389
73Ether lipid metabolism_Homo sapiens_hsa005650.68499834
74Nicotine addiction_Homo sapiens_hsa050330.67389875
75Arachidonic acid metabolism_Homo sapiens_hsa005900.65965348
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64464402
77Olfactory transduction_Homo sapiens_hsa047400.62706722
78Fatty acid metabolism_Homo sapiens_hsa012120.60714312
79Taste transduction_Homo sapiens_hsa047420.59227707
80Cardiac muscle contraction_Homo sapiens_hsa042600.58613887
81Hematopoietic cell lineage_Homo sapiens_hsa046400.56971384
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56430631
83Morphine addiction_Homo sapiens_hsa050320.52965295
84Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51756743
85Retinol metabolism_Homo sapiens_hsa008300.47718166
86Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46082245
87Biosynthesis of amino acids_Homo sapiens_hsa012300.44871023
88Carbon metabolism_Homo sapiens_hsa012000.44400336
89Fatty acid biosynthesis_Homo sapiens_hsa000610.44354344
90Systemic lupus erythematosus_Homo sapiens_hsa053220.43031743
91Fatty acid degradation_Homo sapiens_hsa000710.42846891
92Steroid biosynthesis_Homo sapiens_hsa001000.42279230
93GABAergic synapse_Homo sapiens_hsa047270.42081482
94Fat digestion and absorption_Homo sapiens_hsa049750.41833215
95NF-kappa B signaling pathway_Homo sapiens_hsa040640.41631525
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41494778
97Arginine and proline metabolism_Homo sapiens_hsa003300.39334422
98Pyruvate metabolism_Homo sapiens_hsa006200.36469489
99Sulfur relay system_Homo sapiens_hsa041220.36351431
100Primary bile acid biosynthesis_Homo sapiens_hsa001200.34004252

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