HNRNPCP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)8.41935890
2cytidine metabolic process (GO:0046087)7.72561319
3cytidine catabolic process (GO:0006216)7.72561319
4cytidine deamination (GO:0009972)7.72561319
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450917.60861069
6pyrimidine ribonucleoside catabolic process (GO:0046133)6.75516323
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.83284944
8Arp2/3 complex-mediated actin nucleation (GO:0034314)4.61987837
9sequestering of actin monomers (GO:0042989)4.36194759
10mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.30602738
11energy coupled proton transport, down electrochemical gradient (GO:0015985)4.25288334
12ATP synthesis coupled proton transport (GO:0015986)4.25288334
13actin nucleation (GO:0045010)4.16395818
14regulation of cellular amino acid metabolic process (GO:0006521)4.07565899
15negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.02131436
16proteasome assembly (GO:0043248)3.96526720
17RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.88657597
18tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.88657597
19respiratory electron transport chain (GO:0022904)3.87931891
20DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.86721729
21electron transport chain (GO:0022900)3.81784245
22protein neddylation (GO:0045116)3.78167997
23signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.76094981
24signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.76094981
25signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.76094981
26establishment of protein localization to mitochondrial membrane (GO:0090151)3.75532143
27intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.74999990
28signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.74999990
29positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.72920311
30regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.61889286
31negative regulation of ligase activity (GO:0051352)3.56949952
32negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.56949952
33signal transduction involved in DNA integrity checkpoint (GO:0072401)3.54416256
34signal transduction involved in DNA damage checkpoint (GO:0072422)3.54416256
35signal transduction involved in cell cycle checkpoint (GO:0072395)3.53656399
36negative regulation of T cell apoptotic process (GO:0070233)3.51646508
37antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.49031466
38protein deneddylation (GO:0000338)3.46560568
39negative regulation by host of viral transcription (GO:0043922)3.46138522
40cullin deneddylation (GO:0010388)3.34847829
41positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.34684651
42regulation of regulatory T cell differentiation (GO:0045589)3.29081518
43anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.28890141
44positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.26125334
45platelet dense granule organization (GO:0060155)3.25039200
46positive regulation of natural killer cell mediated immunity (GO:0002717)3.24662701
47antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.20295158
48transcription elongation from RNA polymerase III promoter (GO:0006385)3.17039695
49termination of RNA polymerase III transcription (GO:0006386)3.17039695
50metallo-sulfur cluster assembly (GO:0031163)3.16049770
51iron-sulfur cluster assembly (GO:0016226)3.16049770
52pyrimidine nucleoside catabolic process (GO:0046135)3.12778018
53positive regulation of ligase activity (GO:0051351)3.07312575
54nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.04925538
55protein complex biogenesis (GO:0070271)3.04087873
56mannosylation (GO:0097502)2.98086097
57respiratory chain complex IV assembly (GO:0008535)2.97433495
58positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.94928358
59positive regulation of B cell differentiation (GO:0045579)2.90900722
60cellular response to interleukin-15 (GO:0071350)2.89727491
61eosinophil chemotaxis (GO:0048245)2.88498672
62rRNA modification (GO:0000154)2.87953489
63DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.87574232
64positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.87111277
65regulation of cellular amine metabolic process (GO:0033238)2.86567212
66exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.84965009
67positive regulation of cell cycle arrest (GO:0071158)2.84765246
68protein-cofactor linkage (GO:0018065)2.83633305
69negative regulation of lymphocyte apoptotic process (GO:0070229)2.77250239
70cytochrome complex assembly (GO:0017004)2.76798605
71negative regulation of viral genome replication (GO:0045071)2.76165608
72negative T cell selection (GO:0043383)2.75723158
73branched-chain amino acid catabolic process (GO:0009083)2.74912361
74regulation of ubiquitin-protein transferase activity (GO:0051438)2.73139144
75positive regulation of interleukin-8 secretion (GO:2000484)2.72649446
76positive regulation of calcium-mediated signaling (GO:0050850)2.72252152
77positive thymic T cell selection (GO:0045059)2.72079954
78hydrogen ion transmembrane transport (GO:1902600)2.68975042
79mitochondrial respiratory chain complex assembly (GO:0033108)2.68960190
80cytolysis (GO:0019835)2.68627761
81chaperone-mediated protein transport (GO:0072321)2.67625862
82water-soluble vitamin biosynthetic process (GO:0042364)2.64770735
83positive T cell selection (GO:0043368)2.64548617
84pyrimidine ribonucleoside metabolic process (GO:0046131)2.64377944
85ATP biosynthetic process (GO:0006754)2.62979927
86regulation of chronic inflammatory response (GO:0002676)2.62825088
87oxidative phosphorylation (GO:0006119)2.62742370
88eosinophil migration (GO:0072677)2.62348564
89mitochondrial respiratory chain complex I assembly (GO:0032981)2.61438263
90NADH dehydrogenase complex assembly (GO:0010257)2.61438263
91mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.61438263
92regulation of isotype switching to IgG isotypes (GO:0048302)2.61339098
93DNA demethylation (GO:0080111)2.60331887
94regulation of ligase activity (GO:0051340)2.59615498
95antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.59565231
96T cell migration (GO:0072678)2.58250441
97GPI anchor biosynthetic process (GO:0006506)2.56878363
98proton transport (GO:0015992)2.56078825
99regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.55504163
100regulation of natural killer cell mediated immunity (GO:0002715)2.55504163

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.14192731
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.43207061
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.22818212
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.94458702
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.41850854
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.11534525
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.95164154
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.93378772
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.89943951
10VDR_23849224_ChIP-Seq_CD4+_Human2.73712611
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.50127166
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.49403109
13VDR_22108803_ChIP-Seq_LS180_Human2.47350766
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.40661261
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.39885272
16ELK1_19687146_ChIP-ChIP_HELA_Human2.34339331
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.29814125
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.23927972
19FOXP3_21729870_ChIP-Seq_TREG_Human2.17970206
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.05720705
21ZNF274_21170338_ChIP-Seq_K562_Hela2.03982855
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.00675637
23STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.93930767
24IGF1R_20145208_ChIP-Seq_DFB_Human1.92515031
25IRF8_22096565_ChIP-ChIP_GC-B_Human1.91833548
26PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.85178230
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.77149489
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.68455888
29MYB_26560356_Chip-Seq_TH2_Human1.62466455
30MYC_18940864_ChIP-ChIP_HL60_Human1.61230104
31HOXB4_20404135_ChIP-ChIP_EML_Mouse1.59286412
32E2F4_17652178_ChIP-ChIP_JURKAT_Human1.54066382
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.52741767
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.51486268
35FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.50765447
36TP53_22573176_ChIP-Seq_HFKS_Human1.46138983
37GATA3_26560356_Chip-Seq_TH2_Human1.40655411
38EWS_26573619_Chip-Seq_HEK293_Human1.39728817
39MYC_18358816_ChIP-ChIP_MESCs_Mouse1.38156486
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.37518542
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.36692697
42HTT_18923047_ChIP-ChIP_STHdh_Human1.36302582
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36261853
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.34844889
45GATA3_27048872_Chip-Seq_THYMUS_Human1.29321533
46IRF8_21731497_ChIP-ChIP_J774_Mouse1.29154385
47PADI4_21655091_ChIP-ChIP_MCF-7_Human1.29113132
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.28890448
49AR_20517297_ChIP-Seq_VCAP_Human1.28670248
50CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.28599654
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28346489
52SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.26383638
53GABP_19822575_ChIP-Seq_HepG2_Human1.26283612
54TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22981766
55EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.22379051
56PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.21879059
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.21764279
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.20573828
59DCP1A_22483619_ChIP-Seq_HELA_Human1.18273330
60PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.17166402
61FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16863605
62FOXA1_25329375_ChIP-Seq_VCAP_Human1.16863605
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.16614027
64MYC_18555785_ChIP-Seq_MESCs_Mouse1.16050273
65LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10275001
66EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.10271352
67HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.08665961
68ERG_20517297_ChIP-Seq_VCAP_Human1.06710759
69ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.06707193
70NCOR_22424771_ChIP-Seq_293T_Human1.06117991
71TAF15_26573619_Chip-Seq_HEK293_Human1.06117326
72RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.05806106
73E2F1_18555785_ChIP-Seq_MESCs_Mouse1.04818572
74NANOG_19829295_ChIP-Seq_ESCs_Human1.04429443
75SOX2_19829295_ChIP-Seq_ESCs_Human1.04429443
76IRF1_19129219_ChIP-ChIP_H3396_Human1.04383010
77MYC_19030024_ChIP-ChIP_MESCs_Mouse1.04002608
78E2F7_22180533_ChIP-Seq_HELA_Human1.03640836
79ER_23166858_ChIP-Seq_MCF-7_Human1.02536895
80MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02251210
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02085208
82CBP_20019798_ChIP-Seq_JUKART_Human1.02085208
83STAT4_19710469_ChIP-ChIP_TH1__Mouse1.01348864
84CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.00900540
85RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.00366465
86CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.00101553
87POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00097003
88FUS_26573619_Chip-Seq_HEK293_Human1.00063572
89FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00029498
90TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.99833593
91GATA3_26560356_Chip-Seq_TH1_Human0.98981317
92AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98650593
93GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.97710281
94CIITA_25753668_ChIP-Seq_RAJI_Human0.97104243
95GATA6_21074721_ChIP-Seq_CACO-2_Human0.96820641
96FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95937923
97TTF2_22483619_ChIP-Seq_HELA_Human0.95394206
98GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.94879049
99NFE2_27457419_Chip-Seq_LIVER_Mouse0.94396891
100ELK1_22589737_ChIP-Seq_MCF10A_Human0.92926025

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.43649418
2MP0002102_abnormal_ear_morphology3.04239630
3MP0006072_abnormal_retinal_apoptosis2.59898642
4MP0008877_abnormal_DNA_methylation2.49188902
5MP0009785_altered_susceptibility_to2.41998834
6MP0004147_increased_porphyrin_level2.40058721
7MP0009333_abnormal_splenocyte_physiolog2.23939908
8MP0000372_irregular_coat_pigmentation2.14807415
9MP0008995_early_reproductive_senescence2.12648475
10MP0001835_abnormal_antigen_presentation2.03147888
11MP0005645_abnormal_hypothalamus_physiol2.00329314
12MP0008058_abnormal_DNA_repair1.97923212
13MP0005646_abnormal_pituitary_gland1.95626466
14MP0003763_abnormal_thymus_physiology1.95134118
15MP0003786_premature_aging1.87893065
16MP0009697_abnormal_copulation1.81140194
17MP0005000_abnormal_immune_tolerance1.77081048
18MP0005253_abnormal_eye_physiology1.74340210
19MP0001984_abnormal_olfaction1.71905995
20MP0002837_dystrophic_cardiac_calcinosis1.69784550
21MP0008789_abnormal_olfactory_epithelium1.68767930
22MP0006292_abnormal_olfactory_placode1.68663052
23MP0003195_calcinosis1.65981653
24MP0001800_abnormal_humoral_immune1.65090627
25MP0003880_abnormal_central_pattern1.63864546
26MP0002166_altered_tumor_susceptibility1.59048031
27MP0002148_abnormal_hypersensitivity_rea1.58879851
28MP0006082_CNS_inflammation1.55303193
29MP0003787_abnormal_imprinting1.53939658
30MP0002420_abnormal_adaptive_immunity1.51983557
31MP0008872_abnormal_physiological_respon1.51394969
32MP0002723_abnormal_immune_serum1.51298515
33MP0001764_abnormal_homeostasis1.47237005
34MP0003011_delayed_dark_adaptation1.47175110
35MP0005379_endocrine/exocrine_gland_phen1.45650229
36MP0001819_abnormal_immune_cell1.45485423
37MP0005551_abnormal_eye_electrophysiolog1.44958821
38MP0001790_abnormal_immune_system1.41620957
39MP0005387_immune_system_phenotype1.41620957
40MP0002277_abnormal_respiratory_mucosa1.40844086
41MP0001905_abnormal_dopamine_level1.40516777
42MP0006035_abnormal_mitochondrial_morpho1.38114405
43MP0002163_abnormal_gland_morphology1.37615685
44MP0001529_abnormal_vocalization1.36722863
45MP0006036_abnormal_mitochondrial_physio1.34671188
46MP0005025_abnormal_response_to1.32464373
47MP0001873_stomach_inflammation1.30718788
48MP0004145_abnormal_muscle_electrophysio1.30678538
49MP0005360_urolithiasis1.28487534
50MP0002006_tumorigenesis1.27585006
51MP0000689_abnormal_spleen_morphology1.24327630
52MP0002398_abnormal_bone_marrow1.23705217
53MP0006276_abnormal_autonomic_nervous1.22313934
54MP0001968_abnormal_touch/_nociception1.21547078
55MP0002138_abnormal_hepatobiliary_system1.21480922
56MP0001919_abnormal_reproductive_system1.19593185
57MP0002452_abnormal_antigen_presenting1.18069767
58MP0000716_abnormal_immune_system1.18021718
59MP0002736_abnormal_nociception_after1.17836575
60MP0005410_abnormal_fertilization1.17688419
61MP0003866_abnormal_defecation1.17507867
62MP0001661_extended_life_span1.16860205
63MP0008875_abnormal_xenobiotic_pharmacok1.16464261
64MP0000703_abnormal_thymus_morphology1.15275364
65MP0005084_abnormal_gallbladder_morpholo1.14380404
66MP0004142_abnormal_muscle_tone1.13730061
67MP0002405_respiratory_system_inflammati1.12012019
68MP0002722_abnormal_immune_system1.10447279
69MP0005389_reproductive_system_phenotype1.10159004
70MP0005636_abnormal_mineral_homeostasis1.04817349
71MP0005075_abnormal_melanosome_morpholog0.99907343
72MP0001845_abnormal_inflammatory_respons0.99555617
73MP0000685_abnormal_immune_system0.99342291
74MP0005377_hearing/vestibular/ear_phenot0.97274954
75MP0003878_abnormal_ear_physiology0.97274954
76MP0010094_abnormal_chromosome_stability0.96019121
77MP0003137_abnormal_impulse_conducting0.94487437
78MP0002095_abnormal_skin_pigmentation0.93734885
79MP0005499_abnormal_olfactory_system0.93593419
80MP0005394_taste/olfaction_phenotype0.93593419
81MP0002429_abnormal_blood_cell0.92330093
82MP0005332_abnormal_amino_acid0.92224411
83MP0002693_abnormal_pancreas_physiology0.91151698
84MP0002876_abnormal_thyroid_physiology0.90234255
85MP0010155_abnormal_intestine_physiology0.89845098
86MP0003045_fibrosis0.89640343
87MP0004957_abnormal_blastocyst_morpholog0.87208887
88MP0003186_abnormal_redox_activity0.87087763
89MP0002234_abnormal_pharynx_morphology0.85367522
90MP0005083_abnormal_biliary_tract0.85334591
91MP0002638_abnormal_pupillary_reflex0.84345338
92MP0001853_heart_inflammation0.84262075
93MP0001485_abnormal_pinna_reflex0.83308039
94MP0003806_abnormal_nucleotide_metabolis0.80678569
95MP0009745_abnormal_behavioral_response0.79309175
96MP0001929_abnormal_gametogenesis0.77586253
97MP0008469_abnormal_protein_level0.76955790
98MP0009764_decreased_sensitivity_to0.76034667
99MP0009046_muscle_twitch0.75740372
100MP0001119_abnormal_female_reproductive0.75717148

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)4.63193746
2Mitochondrial inheritance (HP:0001427)4.23294991
3Acute necrotizing encephalopathy (HP:0006965)4.23089187
4Severe combined immunodeficiency (HP:0004430)3.98919021
5Abnormal mitochondria in muscle tissue (HP:0008316)3.82034190
6Hepatocellular necrosis (HP:0001404)3.81671715
73-Methylglutaconic aciduria (HP:0003535)3.78223800
8Increased CSF lactate (HP:0002490)3.73465930
9Progressive macrocephaly (HP:0004481)3.67053059
10IgG deficiency (HP:0004315)3.62370787
11Acute encephalopathy (HP:0006846)3.58562443
12T lymphocytopenia (HP:0005403)3.55464204
13Hepatic necrosis (HP:0002605)3.44308295
14Abnormality of T cell number (HP:0011839)3.36248559
15Increased hepatocellular lipid droplets (HP:0006565)3.31917067
16Cerebral edema (HP:0002181)3.26354042
17Combined immunodeficiency (HP:0005387)3.16334011
18Thyroiditis (HP:0100646)3.11249732
19Pancreatic cysts (HP:0001737)3.06592887
20Lipid accumulation in hepatocytes (HP:0006561)3.00485496
21Hypoproteinemia (HP:0003075)2.90343665
22Autoimmune hemolytic anemia (HP:0001890)2.78050020
23True hermaphroditism (HP:0010459)2.77657071
24Increased IgM level (HP:0003496)2.77159678
25Increased intramyocellular lipid droplets (HP:0012240)2.76165179
26Abnormality of T cells (HP:0002843)2.73342294
27Type I transferrin isoform profile (HP:0003642)2.71393811
28Increased serum lactate (HP:0002151)2.69424188
29Abnormality of midbrain morphology (HP:0002418)2.68710257
30Molar tooth sign on MRI (HP:0002419)2.68710257
31Attenuation of retinal blood vessels (HP:0007843)2.67773133
32Lactic acidosis (HP:0003128)2.65985588
33Pancreatic fibrosis (HP:0100732)2.63605279
34Abnormality of eosinophils (HP:0001879)2.61919391
35Elevated erythrocyte sedimentation rate (HP:0003565)2.53501527
36Renal Fanconi syndrome (HP:0001994)2.51917377
37Chronic diarrhea (HP:0002028)2.49357494
38Pancytopenia (HP:0001876)2.46220388
39Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.43756031
40Decreased activity of mitochondrial respiratory chain (HP:0008972)2.43756031
41Decreased electroretinogram (ERG) amplitude (HP:0000654)2.41486662
42Optic disc pallor (HP:0000543)2.40303353
43Absent rod-and cone-mediated responses on ERG (HP:0007688)2.39980789
44Abolished electroretinogram (ERG) (HP:0000550)2.38375872
45Respiratory failure (HP:0002878)2.34274183
46Lethargy (HP:0001254)2.34132790
47Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.32405007
48Abnormality of alanine metabolism (HP:0010916)2.32405007
49Hyperalaninemia (HP:0003348)2.32405007
50Abnormal glycosylation (HP:0012345)2.28143319
51Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.28143319
52Abnormal protein N-linked glycosylation (HP:0012347)2.28143319
53Abnormal protein glycosylation (HP:0012346)2.28143319
54Methylmalonic acidemia (HP:0002912)2.26494746
55Increased muscle lipid content (HP:0009058)2.26393913
56Methylmalonic aciduria (HP:0012120)2.21392717
57Decreased central vision (HP:0007663)2.20790654
58Congenital stationary night blindness (HP:0007642)2.19662606
59Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.15000082
60Renal cortical cysts (HP:0000803)2.13212247
61Abnormal rod and cone electroretinograms (HP:0008323)2.11309918
62Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.11168662
63Constricted visual fields (HP:0001133)2.10667524
64B lymphocytopenia (HP:0010976)2.09985342
65Exertional dyspnea (HP:0002875)2.09266487
66Dicarboxylic aciduria (HP:0003215)2.09147342
67Abnormality of dicarboxylic acid metabolism (HP:0010995)2.09147342
68Exercise intolerance (HP:0003546)2.07223949
69Eosinophilia (HP:0001880)2.07169633
70Aplasia/hypoplasia of the uterus (HP:0008684)2.07009158
71Abnormality of B cell number (HP:0010975)2.06389319
72Abnormality of the prostate (HP:0008775)2.06090021
73Medial flaring of the eyebrow (HP:0010747)2.04026656
74Ketoacidosis (HP:0001993)2.03957318
75Nephronophthisis (HP:0000090)2.02186607
76Ketosis (HP:0001946)2.01943048
77CNS demyelination (HP:0007305)1.98365619
78Hypothermia (HP:0002045)1.95724787
79Nephrogenic diabetes insipidus (HP:0009806)1.88262605
80Hypomagnesemia (HP:0002917)1.88103046
81Pendular nystagmus (HP:0012043)1.86494600
82Hyperglycinemia (HP:0002154)1.85979428
83Generalized aminoaciduria (HP:0002909)1.84539929
84Granulocytopenia (HP:0001913)1.82837483
85Type 2 muscle fiber atrophy (HP:0003554)1.82467647
86Abnormality of the renal cortex (HP:0011035)1.80417770
87Hypoalbuminemia (HP:0003073)1.80314486
88Abnormal albumin level (HP:0012116)1.80314486
89Recurrent cutaneous fungal infections (HP:0011370)1.78537352
90Chronic mucocutaneous candidiasis (HP:0002728)1.78537352
91Emotional lability (HP:0000712)1.78530296
92Type II lissencephaly (HP:0007260)1.76938569
93Abnormality of T cell physiology (HP:0011840)1.75835283
94Chronic sinusitis (HP:0011109)1.75337347
95Encephalitis (HP:0002383)1.74642382
96Congenital primary aphakia (HP:0007707)1.72225235
97Leukocytosis (HP:0001974)1.71106818
98Leukodystrophy (HP:0002415)1.70454945
99Abnormality of serum amino acid levels (HP:0003112)1.70062849
100Cerebral hypomyelination (HP:0006808)1.69041788

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.78649812
2KDR4.44562650
3TESK23.94462516
4BCKDK3.55129030
5ZAK3.11333483
6VRK22.68656991
7MAP4K22.58402680
8BUB12.33334563
9TRIM282.30875717
10MST42.23026490
11VRK12.17338126
12FRK2.11243020
13ADRBK22.00827400
14TLK11.88391860
15BCR1.80332648
16EIF2AK31.73395329
17ITK1.69883432
18NUAK11.65052811
19SRPK11.52577327
20LIMK11.49523340
21TESK11.49411836
22MAP4K11.49207509
23MAP2K71.43155310
24GRK11.40961074
25CSNK1G31.23369016
26RPS6KA41.23014099
27INSRR1.16786810
28WNK31.10306197
29CSNK1G11.10032911
30PINK11.04804871
31MAP3K41.04384669
32SCYL21.02599477
33TAOK31.01894788
34SYK0.97225077
35PRKCQ0.95926652
36GRK60.93942723
37FES0.93360214
38TEC0.91394805
39CSNK1A1L0.91084840
40PLK20.90956024
41PLK30.90365915
42CSNK1G20.88306437
43PLK40.85811173
44TNK20.83793645
45MAPK130.82893280
46WNK40.81347084
47DAPK10.79572395
48MUSK0.78873583
49ERBB30.78506966
50LCK0.77173807
51RPS6KA50.74564710
52NME10.74504786
53LYN0.73574978
54MAP3K120.65753911
55MATK0.64256402
56DYRK20.63161621
57IKBKB0.60107303
58ATR0.57676079
59EIF2AK10.55833330
60TIE10.55226362
61PLK10.54018157
62GRK70.53065570
63MAPKAPK30.52565726
64CCNB10.52455018
65PIK3CG0.51320107
66BMPR20.51112705
67BTK0.49608813
68CSNK1A10.48854560
69PHKG10.48572860
70PHKG20.48572860
71CSNK2A10.46295877
72CAMKK20.45982158
73PIM10.45438848
74PDK20.44366589
75MAP3K50.44153995
76NLK0.43358786
77PRKCE0.43248700
78CSK0.41236163
79EPHA30.40510319
80CSNK2A20.39120662
81AURKA0.37379429
82IKBKE0.37372322
83PRKCA0.36188368
84PIM20.35790986
85BMPR1B0.35703299
86TSSK60.35143797
87PRKACA0.35038736
88OBSCN0.34400875
89OXSR10.34349285
90CDC70.33642243
91MAPKAPK50.33024793
92EPHA40.32366361
93ZAP700.31962754
94AURKB0.31559303
95PAK10.30939990
96JAK30.30770584
97IGF1R0.30710825
98DAPK20.30595944
99MYLK0.29785843
100ROCK10.28487771

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.27085613
2Oxidative phosphorylation_Homo sapiens_hsa001903.74015878
3Primary immunodeficiency_Homo sapiens_hsa053403.71472707
4Parkinsons disease_Homo sapiens_hsa050123.17226106
5Protein export_Homo sapiens_hsa030602.84340559
6RNA polymerase_Homo sapiens_hsa030202.83619722
7Graft-versus-host disease_Homo sapiens_hsa053322.23084042
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.14519793
9Autoimmune thyroid disease_Homo sapiens_hsa053202.04900017
10Antigen processing and presentation_Homo sapiens_hsa046121.97009662
11Alzheimers disease_Homo sapiens_hsa050101.96624476
12Huntingtons disease_Homo sapiens_hsa050161.95508946
13Type I diabetes mellitus_Homo sapiens_hsa049401.95282381
14Allograft rejection_Homo sapiens_hsa053301.94467434
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.94039366
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.87696455
17Homologous recombination_Homo sapiens_hsa034401.79248351
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.77305054
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.67099984
20Butanoate metabolism_Homo sapiens_hsa006501.63582772
21Mismatch repair_Homo sapiens_hsa034301.58193655
22Propanoate metabolism_Homo sapiens_hsa006401.57481874
23Hematopoietic cell lineage_Homo sapiens_hsa046401.39233363
24Spliceosome_Homo sapiens_hsa030401.35670095
25Ribosome_Homo sapiens_hsa030101.34255874
26Rheumatoid arthritis_Homo sapiens_hsa053231.33616598
27DNA replication_Homo sapiens_hsa030301.33260467
28RNA degradation_Homo sapiens_hsa030181.32669079
29Fatty acid elongation_Homo sapiens_hsa000621.30415347
30Cardiac muscle contraction_Homo sapiens_hsa042601.27368186
31Phototransduction_Homo sapiens_hsa047441.21375430
32One carbon pool by folate_Homo sapiens_hsa006701.15925593
33Pyrimidine metabolism_Homo sapiens_hsa002401.14170475
34Peroxisome_Homo sapiens_hsa041461.12884309
35Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.10467352
36Intestinal immune network for IgA production_Homo sapiens_hsa046721.09128437
37Fanconi anemia pathway_Homo sapiens_hsa034601.08932773
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.08867820
39Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.08422180
40SNARE interactions in vesicular transport_Homo sapiens_hsa041301.07671473
41Nucleotide excision repair_Homo sapiens_hsa034201.02967179
42RNA transport_Homo sapiens_hsa030131.00962412
43Purine metabolism_Homo sapiens_hsa002300.99895217
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.99098978
45Non-homologous end-joining_Homo sapiens_hsa034500.97587200
46Asthma_Homo sapiens_hsa053100.97368089
47Nitrogen metabolism_Homo sapiens_hsa009100.94893144
48Caffeine metabolism_Homo sapiens_hsa002320.94520118
49Collecting duct acid secretion_Homo sapiens_hsa049660.87987689
50Basal transcription factors_Homo sapiens_hsa030220.85694132
51T cell receptor signaling pathway_Homo sapiens_hsa046600.85068365
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84656630
53Sulfur metabolism_Homo sapiens_hsa009200.84339694
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78135284
55Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.77960069
56Steroid biosynthesis_Homo sapiens_hsa001000.77506513
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76482694
58Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.74128495
59Cysteine and methionine metabolism_Homo sapiens_hsa002700.72038625
60Base excision repair_Homo sapiens_hsa034100.71589952
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71128910
62Olfactory transduction_Homo sapiens_hsa047400.66742335
63Fatty acid metabolism_Homo sapiens_hsa012120.65661209
64Regulation of autophagy_Homo sapiens_hsa041400.64120294
65Folate biosynthesis_Homo sapiens_hsa007900.63378209
66Metabolic pathways_Homo sapiens_hsa011000.62413061
67Retinol metabolism_Homo sapiens_hsa008300.60365207
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.55498854
69Tryptophan metabolism_Homo sapiens_hsa003800.53985864
70Measles_Homo sapiens_hsa051620.53674380
71Taste transduction_Homo sapiens_hsa047420.53012544
72Linoleic acid metabolism_Homo sapiens_hsa005910.52009310
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51647087
74NF-kappa B signaling pathway_Homo sapiens_hsa040640.50874920
75Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50379444
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.49457831
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49059618
78Viral myocarditis_Homo sapiens_hsa054160.48781251
79Epstein-Barr virus infection_Homo sapiens_hsa051690.46811537
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46610459
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46062448
82Shigellosis_Homo sapiens_hsa051310.45456304
83Salmonella infection_Homo sapiens_hsa051320.42475363
84Nicotine addiction_Homo sapiens_hsa050330.42175546
85Systemic lupus erythematosus_Homo sapiens_hsa053220.41460649
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.39618490
87Pyruvate metabolism_Homo sapiens_hsa006200.38843406
88Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.38369599
89Chemical carcinogenesis_Homo sapiens_hsa052040.36688904
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.35105340
912-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.32829675
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30736314
93mRNA surveillance pathway_Homo sapiens_hsa030150.29021290
94Biosynthesis of amino acids_Homo sapiens_hsa012300.26729683
95Fatty acid degradation_Homo sapiens_hsa000710.26142587
96beta-Alanine metabolism_Homo sapiens_hsa004100.24047773
97Selenocompound metabolism_Homo sapiens_hsa004500.23980889
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.23659140
99Carbon metabolism_Homo sapiens_hsa012000.23065041
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.22838925

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