HNRNPCL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of acrosome reaction (GO:0060046)4.58223493
2positive regulation of uterine smooth muscle contraction (GO:0070474)4.52132127
3positive regulation of prostaglandin secretion (GO:0032308)4.49763917
4rRNA modification (GO:0000154)4.48875292
5DNA deamination (GO:0045006)4.36731566
6regulation of cytokine production involved in inflammatory response (GO:1900015)4.35816483
7multicellular organism reproduction (GO:0032504)4.28172961
8male meiosis I (GO:0007141)4.20187023
9rRNA methylation (GO:0031167)4.17348129
10negative regulation of retinoic acid receptor signaling pathway (GO:0048387)32.9330205
11meiosis I (GO:0007127)3.78964629
12regulation of prostaglandin secretion (GO:0032306)3.70470211
13regulation of female gonad development (GO:2000194)3.69272292
14protein kinase C signaling (GO:0070528)3.46586365
15chaperone-mediated protein transport (GO:0072321)3.45681787
16aggressive behavior (GO:0002118)3.45533515
17positive regulation of humoral immune response (GO:0002922)3.42910088
18transcription from mitochondrial promoter (GO:0006390)3.42431371
19regulation of uterine smooth muscle contraction (GO:0070472)3.35625529
20sleep (GO:0030431)3.28163561
21maturation of SSU-rRNA (GO:0030490)3.24487877
22proteasome assembly (GO:0043248)3.17743319
23termination of RNA polymerase III transcription (GO:0006386)3.16666275
24transcription elongation from RNA polymerase III promoter (GO:0006385)3.16666275
25regulation of penile erection (GO:0060405)3.16535533
26regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.12767852
27regulation of female receptivity (GO:0045924)3.08145625
28regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.07207733
29regulation of retinoic acid receptor signaling pathway (GO:0048385)27.8225448
30hyperosmotic salinity response (GO:0042538)2.98470328
31negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.97096539
32glycine transport (GO:0015816)2.94792212
33positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.94287981
34positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.93408823
35positive regulation of fatty acid transport (GO:2000193)2.93252235
36drinking behavior (GO:0042756)2.88868363
37positive regulation of icosanoid secretion (GO:0032305)2.84928864
38cytidine metabolic process (GO:0046087)2.84707603
39cytidine catabolic process (GO:0006216)2.84707603
40cytidine deamination (GO:0009972)2.84707603
41establishment of protein localization to mitochondrial membrane (GO:0090151)2.83528009
42regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.81595002
43reproduction (GO:0000003)2.81470684
44anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.80517539
45chaperone mediated protein folding requiring cofactor (GO:0051085)2.77264561
46mitochondrial RNA metabolic process (GO:0000959)2.75981853
47ribosome assembly (GO:0042255)2.75640035
48protein K6-linked ubiquitination (GO:0085020)2.74392306
49male meiosis (GO:0007140)2.69633937
50female mating behavior (GO:0060180)2.66241255
51positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.65957088
52negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.63799053
53negative regulation of ligase activity (GO:0051352)2.63799053
54negative regulation of reproductive process (GO:2000242)2.63570417
55regulation of DNA methylation (GO:0044030)2.63375300
56regulation of cellular amino acid metabolic process (GO:0006521)2.59985360
57positive regulation of ligase activity (GO:0051351)2.55996525
58rRNA processing (GO:0006364)2.54305549
59tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.53078751
60RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.53078751
61regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.51099640
62pyrimidine ribonucleoside catabolic process (GO:0046133)2.50089923
63positive regulation of protein homooligomerization (GO:0032464)2.49181759
64binding of sperm to zona pellucida (GO:0007339)2.49099221
65nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.48856708
66oocyte development (GO:0048599)2.47421393
67mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.46475922
68rRNA metabolic process (GO:0016072)2.44251219
69histone mRNA metabolic process (GO:0008334)2.42656802
70DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.40592461
71telomere maintenance via telomere lengthening (GO:0010833)2.40579857
72exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.39683178
73positive regulation of digestive system process (GO:0060456)2.37723873
74positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.37663764
75negative regulation of digestive system process (GO:0060457)2.36636622
76sperm-egg recognition (GO:0035036)2.36070971
77regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.34853661
78positive regulation of interleukin-17 production (GO:0032740)2.32304020
79signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.31920582
80signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.31920582
81signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.31920582
82intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.31324071
83signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.31324071
84transcription from RNA polymerase III promoter (GO:0006383)2.29248071
85positive regulation of catecholamine secretion (GO:0033605)2.28780947
86base-excision repair, AP site formation (GO:0006285)2.28105762
87mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.26464995
88regulation of RIG-I signaling pathway (GO:0039535)2.25673651
89piRNA metabolic process (GO:0034587)2.25465010
90energy coupled proton transport, down electrochemical gradient (GO:0015985)2.25004613
91ATP synthesis coupled proton transport (GO:0015986)2.25004613
92ribosomal small subunit assembly (GO:0000028)2.20196389
93regulation of ubiquitin-protein transferase activity (GO:0051438)2.19464883
94signal transduction involved in DNA damage checkpoint (GO:0072422)2.18761897
95signal transduction involved in DNA integrity checkpoint (GO:0072401)2.18761897
96mitotic metaphase plate congression (GO:0007080)2.16690677
97signal transduction involved in cell cycle checkpoint (GO:0072395)2.14867395
98DNA replication checkpoint (GO:0000076)2.14714055
99meiotic cell cycle (GO:0051321)2.13347977
100regulation of ligase activity (GO:0051340)2.13166283

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.88679687
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.37726610
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.09696370
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.78390118
5NOTCH1_21737748_ChIP-Seq_TLL_Human3.75836672
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.27361530
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.25759166
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.20030684
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.15828746
10E2F7_22180533_ChIP-Seq_HELA_Human3.12804593
11ETS1_20019798_ChIP-Seq_JURKAT_Human3.07160811
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.06899995
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.94250962
14ZNF274_21170338_ChIP-Seq_K562_Hela2.89062396
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.67574926
16VDR_23849224_ChIP-Seq_CD4+_Human2.63486508
17MYC_18940864_ChIP-ChIP_HL60_Human2.29480449
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.19797436
19KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.18389791
20KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.18389791
21KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.18389791
22FOXP3_21729870_ChIP-Seq_TREG_Human2.09349639
23MYC_18555785_ChIP-Seq_MESCs_Mouse2.08874208
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.07520429
25BP1_19119308_ChIP-ChIP_Hs578T_Human1.97668085
26YY1_21170310_ChIP-Seq_MESCs_Mouse1.93651606
27ETV1_20927104_ChIP-Seq_GIST48_Human1.91093013
28ELK1_19687146_ChIP-ChIP_HELA_Human1.90531681
29* RBPJ_21746931_ChIP-Seq_IB4_Human1.87961879
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.86277964
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.78453905
32FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.78351484
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.77513045
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.76643538
35GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.76202200
36EZH2_22144423_ChIP-Seq_EOC_Human1.75995617
37E2F4_17652178_ChIP-ChIP_JURKAT_Human1.75330175
38MYC_18358816_ChIP-ChIP_MESCs_Mouse1.75123752
39VDR_22108803_ChIP-Seq_LS180_Human1.67838453
40GATA6_21074721_ChIP-Seq_CACO-2_Human1.64544223
41* PHF8_20622853_ChIP-Seq_HELA_Human1.62926000
42SRF_21415370_ChIP-Seq_HL-1_Mouse1.60981840
43* NFYB_21822215_ChIP-Seq_K562_Human1.58853478
44CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.58086269
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.57749649
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.54947076
47RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51276128
48MYC_19030024_ChIP-ChIP_MESCs_Mouse1.49778997
49TP63_19390658_ChIP-ChIP_HaCaT_Human1.49057192
50TTF2_22483619_ChIP-Seq_HELA_Human1.46165989
51HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.42899566
52TBL1_22424771_ChIP-Seq_293T_Human1.40805145
53MYC_19079543_ChIP-ChIP_MESCs_Mouse1.39166664
54HNFA_21074721_ChIP-Seq_CACO-2_Human1.37957152
55AUTS2_25519132_ChIP-Seq_293T-REX_Human1.37047993
56PADI4_21655091_ChIP-ChIP_MCF-7_Human1.36156204
57GABP_19822575_ChIP-Seq_HepG2_Human1.35652043
58ELK1_22589737_ChIP-Seq_MCF10A_Human1.31522965
59TP53_22573176_ChIP-Seq_HFKS_Human1.30814344
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.30600291
61NANOG_20526341_ChIP-Seq_ESCs_Human1.29606956
62GATA3_26560356_Chip-Seq_TH2_Human1.29471679
63XRN2_22483619_ChIP-Seq_HELA_Human1.27440442
64CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.25473324
65POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17686613
66FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17334067
67IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.14263920
68NFYA_21822215_ChIP-Seq_K562_Human1.13908689
69CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.12557936
70PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12553006
71THAP11_20581084_ChIP-Seq_MESCs_Mouse1.12314938
72NCOR_22424771_ChIP-Seq_293T_Human1.11754850
73EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09782328
74CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.09038717
75FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.08583068
76SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.07035823
77IRF1_19129219_ChIP-ChIP_H3396_Human1.05057107
78E2F1_18555785_ChIP-Seq_MESCs_Mouse1.04725162
79CIITA_25753668_ChIP-Seq_RAJI_Human1.04667634
80KAP1_22055183_ChIP-Seq_ESCs_Mouse1.03861105
81CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00309735
82ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.99881737
83PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98905644
84POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.98872158
85FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.97431828
86SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.97331690
87EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.97074538
88GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96989310
89YY1_22570637_ChIP-Seq_MALME-3M_Human0.96183187
90FOXH1_21741376_ChIP-Seq_EPCs_Human0.96179954
91* PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.96151814
92NELFA_20434984_ChIP-Seq_ESCs_Mouse0.95650873
93STAT1_20625510_ChIP-Seq_HELA_Human0.95426574
94DCP1A_22483619_ChIP-Seq_HELA_Human0.94060402
95ETV2_25802403_ChIP-Seq_MESCs_Mouse0.93840829
96TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.90076609
97MYC_19829295_ChIP-Seq_ESCs_Human0.89497282
98FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89234826
99HOXB7_26014856_ChIP-Seq_BT474_Human0.89118267
100SOX2_21211035_ChIP-Seq_LN229_Human0.89068386

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001986_abnormal_taste_sensitivity4.08747390
2MP0003718_maternal_effect4.02739586
3MP0006292_abnormal_olfactory_placode3.52760417
4MP0005423_abnormal_somatic_nervous2.88981187
5MP0009379_abnormal_foot_pigmentation2.77805433
6MP0003693_abnormal_embryo_hatching2.64188575
7MP0002138_abnormal_hepatobiliary_system2.61891294
8MP0000372_irregular_coat_pigmentation2.58143140
9MP0005410_abnormal_fertilization2.48151879
10MP0008877_abnormal_DNA_methylation2.41689524
11MP0009333_abnormal_splenocyte_physiolog2.36714411
12MP0003195_calcinosis2.34870312
13MP0003646_muscle_fatigue2.11197655
14MP0010094_abnormal_chromosome_stability2.09828632
15MP0008058_abnormal_DNA_repair2.08449948
16MP0005671_abnormal_response_to2.06077893
17MP0006276_abnormal_autonomic_nervous2.05926942
18MP0003136_yellow_coat_color2.03735336
19MP0004957_abnormal_blastocyst_morpholog2.01713901
20MP0003283_abnormal_digestive_organ2.01600177
21MP0002277_abnormal_respiratory_mucosa1.95869057
22MP0004142_abnormal_muscle_tone1.92453303
23MP0001929_abnormal_gametogenesis1.88977646
24MP0001881_abnormal_mammary_gland1.88190467
25MP0003786_premature_aging1.84566155
26MP0005360_urolithiasis1.81851323
27MP0005394_taste/olfaction_phenotype1.79436028
28MP0005499_abnormal_olfactory_system1.79436028
29MP0002210_abnormal_sex_determination1.76826105
30MP0005389_reproductive_system_phenotype1.76387654
31MP0005395_other_phenotype1.75388405
32MP0002160_abnormal_reproductive_system1.70741164
33MP0003866_abnormal_defecation1.70136173
34MP0001835_abnormal_antigen_presentation1.57236358
35MP0002102_abnormal_ear_morphology1.55670248
36MP0008789_abnormal_olfactory_epithelium1.55291910
37MP0005646_abnormal_pituitary_gland1.53456494
38MP0003077_abnormal_cell_cycle1.49885690
39MP0005647_abnormal_sex_gland1.45831430
40MP0002139_abnormal_hepatobiliary_system1.44128177
41MP0005645_abnormal_hypothalamus_physiol1.44058855
42MP0001502_abnormal_circadian_rhythm1.43106177
43MP0006036_abnormal_mitochondrial_physio1.42996116
44MP0008932_abnormal_embryonic_tissue1.41399374
45MP0003111_abnormal_nucleus_morphology1.41348307
46MP0005075_abnormal_melanosome_morpholog1.32468519
47MP0010368_abnormal_lymphatic_system1.32061133
48MP0001984_abnormal_olfaction1.30795575
49MP0000653_abnormal_sex_gland1.27154559
50MP0001919_abnormal_reproductive_system1.26684535
51MP0001790_abnormal_immune_system1.24869496
52MP0005387_immune_system_phenotype1.24869496
53MP0001119_abnormal_female_reproductive1.15995785
54MP0002127_abnormal_cardiovascular_syste1.12352465
55MP0009785_altered_susceptibility_to1.11151214
56MP0003699_abnormal_female_reproductive1.07885602
57MP0002148_abnormal_hypersensitivity_rea1.07356588
58MP0008995_early_reproductive_senescence1.03450166
59MP0001529_abnormal_vocalization1.02305721
60MP0003698_abnormal_male_reproductive1.01485354
61MP0001145_abnormal_male_reproductive1.00482547
62MP0001800_abnormal_humoral_immune1.00385770
63MP0010307_abnormal_tumor_latency0.97859358
64MP0004215_abnormal_myocardial_fiber0.97321168
65MP0001968_abnormal_touch/_nociception0.97297416
66MP0002006_tumorigenesis0.97174300
67MP0005551_abnormal_eye_electrophysiolog0.95706547
68MP0003567_abnormal_fetal_cardiomyocyte0.94603016
69MP0002161_abnormal_fertility/fecundity0.93879974
70MP0001501_abnormal_sleep_pattern0.93759420
71MP0005000_abnormal_immune_tolerance0.92069346
72MP0003186_abnormal_redox_activity0.90035721
73MP0002736_abnormal_nociception_after0.84797273
74MP0001853_heart_inflammation0.83434872
75MP0003252_abnormal_bile_duct0.82997392
76MP0008872_abnormal_physiological_respon0.81732817
77MP0006072_abnormal_retinal_apoptosis0.79391430
78MP0002420_abnormal_adaptive_immunity0.78897469
79MP0002166_altered_tumor_susceptibility0.78797026
80MP0002938_white_spotting0.78564989
81MP0004145_abnormal_muscle_electrophysio0.77936426
82MP0002272_abnormal_nervous_system0.77843111
83MP0009697_abnormal_copulation0.77240591
84MP0002723_abnormal_immune_serum0.76167927
85MP0009840_abnormal_foam_cell0.74601692
86MP0001819_abnormal_immune_cell0.74280049
87MP0008057_abnormal_DNA_replication0.72551225
88MP0005084_abnormal_gallbladder_morpholo0.71742174
89MP0001666_abnormal_nutrient_absorption0.71294022
90MP0001293_anophthalmia0.69314516
91MP0005377_hearing/vestibular/ear_phenot0.68311184
92MP0003878_abnormal_ear_physiology0.68311184
93MP0002452_abnormal_antigen_presenting0.67890429
94MP0000631_abnormal_neuroendocrine_gland0.67681090
95MP0000627_abnormal_mammary_gland0.67581467
96MP0001485_abnormal_pinna_reflex0.67357739
97MP0001440_abnormal_grooming_behavior0.67159774
98MP0004742_abnormal_vestibular_system0.65707527
99MP0000689_abnormal_spleen_morphology0.65571054
100MP0002398_abnormal_bone_marrow0.63794481

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.77000702
23-Methylglutaconic aciduria (HP:0003535)3.50875162
3Abnormal mitochondria in muscle tissue (HP:0008316)3.50624006
4Male infertility (HP:0003251)3.45114577
5Mitochondrial inheritance (HP:0001427)3.37167353
6Aplasia/hypoplasia of the uterus (HP:0008684)3.32658905
7Acute encephalopathy (HP:0006846)3.22097360
8Increased hepatocellular lipid droplets (HP:0006565)3.20469025
9Increased CSF lactate (HP:0002490)3.18300405
10Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.18155985
11Premature ovarian failure (HP:0008209)3.17214783
12Stomatitis (HP:0010280)3.11192091
13Rhinitis (HP:0012384)3.01425033
14Progressive macrocephaly (HP:0004481)3.00822067
15Increased serum lactate (HP:0002151)2.95521502
16Aplasia/Hypoplasia of the fovea (HP:0008060)2.86946638
17Hypoplasia of the fovea (HP:0007750)2.86946638
18IgG deficiency (HP:0004315)2.84973798
19Lipid accumulation in hepatocytes (HP:0006561)2.82774222
20Type 2 muscle fiber atrophy (HP:0003554)2.79694722
21Carpal bone hypoplasia (HP:0001498)2.77373244
22Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.72307950
23Abnormality of alanine metabolism (HP:0010916)2.71282701
24Hyperalaninemia (HP:0003348)2.71282701
25Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.71282701
26Constricted visual fields (HP:0001133)2.70048272
27Sensory axonal neuropathy (HP:0003390)2.66564626
28Aplasia/Hypoplasia involving the musculature (HP:0001460)2.66489078
29Cerebral edema (HP:0002181)2.65952645
30Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.65845208
31Abnormal number of erythroid precursors (HP:0012131)2.62209151
32Severe combined immunodeficiency (HP:0004430)2.61864830
33Pendular nystagmus (HP:0012043)2.57890176
34Aplastic anemia (HP:0001915)2.55008167
35Increased intramyocellular lipid droplets (HP:0012240)2.52981175
36Malnutrition (HP:0004395)2.50530930
37Hypoplasia of the uterus (HP:0000013)2.48007418
38Pancreatic cysts (HP:0001737)2.41333443
39Absent rod-and cone-mediated responses on ERG (HP:0007688)2.40440694
40Decreased activity of mitochondrial respiratory chain (HP:0008972)2.39141261
41Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.39141261
42Abnormality of the fovea (HP:0000493)2.38594031
43Renal Fanconi syndrome (HP:0001994)2.38458970
44Abolished electroretinogram (ERG) (HP:0000550)2.37706034
45Abnormality of cells of the erythroid lineage (HP:0012130)2.36886939
46Attenuation of retinal blood vessels (HP:0007843)2.32929213
47Delayed CNS myelination (HP:0002188)2.32671418
48Abnormality of midbrain morphology (HP:0002418)2.32608025
49Molar tooth sign on MRI (HP:0002419)2.32608025
50Microvesicular hepatic steatosis (HP:0001414)2.32569079
51Optic disc pallor (HP:0000543)2.30717570
52Hepatocellular necrosis (HP:0001404)2.30659213
53Reticulocytopenia (HP:0001896)2.29867281
54Abnormality of the ileum (HP:0001549)2.26116159
55Lactic acidosis (HP:0003128)2.25779525
56Bile duct proliferation (HP:0001408)2.25317614
57Abnormal biliary tract physiology (HP:0012439)2.25317614
58Hepatic necrosis (HP:0002605)2.24830997
59Muscle fiber atrophy (HP:0100295)2.24696604
60Abnormal respiratory motile cilium morphology (HP:0005938)2.24534879
61Abnormal respiratory epithelium morphology (HP:0012253)2.24534879
62Meckel diverticulum (HP:0002245)2.22896714
63Chronic diarrhea (HP:0002028)2.22450119
64Congenital ichthyosiform erythroderma (HP:0007431)2.22034972
65Abnormal rod and cone electroretinograms (HP:0008323)2.19619520
66Concave nail (HP:0001598)2.18175732
67Exercise intolerance (HP:0003546)2.16570800
68Exertional dyspnea (HP:0002875)2.13048593
69Abnormality of the septum pellucidum (HP:0007375)2.05740739
70Glycosuria (HP:0003076)2.05131002
71Abnormality of urine glucose concentration (HP:0011016)2.05131002
72Combined immunodeficiency (HP:0005387)2.00831066
73Infertility (HP:0000789)1.98151631
74Testicular atrophy (HP:0000029)1.96757518
75Pancytopenia (HP:0001876)1.96687660
76Increased muscle lipid content (HP:0009058)1.95356080
77Increased IgM level (HP:0003496)1.94734416
78Absent thumb (HP:0009777)1.93934641
79Cleft eyelid (HP:0000625)1.93288863
80Progressive muscle weakness (HP:0003323)1.91158278
81Horseshoe kidney (HP:0000085)1.87846367
82T lymphocytopenia (HP:0005403)1.86622766
83Anhidrosis (HP:0000970)1.84330302
84Absent septum pellucidum (HP:0001331)1.84168679
85Abnormality of T cell number (HP:0011839)1.83000795
86Nausea (HP:0002018)1.82545118
87Hyperphosphaturia (HP:0003109)1.82307017
88Respiratory failure (HP:0002878)1.80865606
89Sparse eyelashes (HP:0000653)1.80226688
90Lethargy (HP:0001254)1.79671844
91Abnormality of the renal collecting system (HP:0004742)1.79626358
92Congenital stationary night blindness (HP:0007642)1.77476829
93Myokymia (HP:0002411)1.74875506
94Abnormality of aspartate family amino acid metabolism (HP:0010899)1.74397677
95Duplicated collecting system (HP:0000081)1.74293071
96Abnormal respiratory motile cilium physiology (HP:0012261)1.73768696
97Male pseudohermaphroditism (HP:0000037)1.73654276
98Abnormality of the preputium (HP:0100587)1.73398342
99Parakeratosis (HP:0001036)1.72660267
100Abnormal ciliary motility (HP:0012262)1.72407322

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK25.72632070
2BUB14.41606436
3EIF2AK33.14983138
4TRIM283.02709272
5VRK23.02283227
6KDR2.75828708
7STK162.72461741
8TXK2.52723381
9SRPK12.50322590
10BCKDK2.29988271
11MUSK2.16100322
12TIE12.03286247
13WNK41.96329413
14TAOK31.92799248
15ZAK1.82865902
16CDK191.82850395
17VRK11.78060442
18TLK11.72477521
19NME11.56126140
20PLK31.54930856
21BRSK21.52349234
22PDK21.46560032
23NEK61.44832874
24ADRBK21.42506464
25PLK41.34409287
26STK391.33451148
27MAPKAPK31.26936896
28PLK11.18291443
29NUAK11.13766660
30GRK11.07785415
31LIMK11.07172912
32TESK11.05659435
33AURKB1.05469942
34PBK1.02317705
35BRSK11.00696464
36MARK30.98313027
37CDC70.97081982
38MAPKAPK50.96936404
39MST40.96282952
40AURKA0.95023954
41TEC0.92289275
42ATR0.86460663
43WNK30.83976760
44ACVR1B0.83909977
45EIF2AK10.83771865
46MAP3K120.83618634
47ITK0.82611800
48FES0.81861335
49TTK0.81336576
50LATS20.78024227
51NEK20.75473953
52CSNK2A10.75405172
53CSNK2A20.73104603
54DAPK10.71434268
55TSSK60.70031129
56BMPR1B0.65769373
57WNK10.64781015
58PRKCG0.64251275
59EIF2AK20.62812562
60GRK60.62338925
61MAP4K10.61497347
62CDK70.61317380
63WEE10.60073449
64PIK3CG0.58905538
65PRKCI0.58764480
66MATK0.57401974
67MAP3K50.52291766
68STK30.51617459
69CSNK1G10.50758657
70CHEK20.50361918
71PRKCE0.49896446
72NEK10.49114207
73OXSR10.48096185
74RPS6KA50.46330037
75MYLK0.45549336
76CSNK1E0.45505016
77PKN10.44186088
78CHEK10.43854096
79PAK10.42962185
80CDK80.42280472
81CSNK1G30.40237404
82INSRR0.35781910
83MAP3K90.35610325
84LYN0.34159905
85CSNK1A1L0.34116642
86CSNK1A10.33673482
87GSK3A0.33252464
88SIK30.33005620
89MAPK110.32765052
90KIT0.31508710
91STK40.30922513
92SYK0.30873069
93MAPKAPK20.29485462
94CLK10.29469261
95PRKCQ0.28721274
96ATM0.27067247
97PRKCA0.25819038
98TGFBR10.25030560
99IGF1R0.24269779
100IKBKB0.24123888

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.39576181
2Basal transcription factors_Homo sapiens_hsa030223.85415846
3Ribosome_Homo sapiens_hsa030103.59659643
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.45170928
5RNA polymerase_Homo sapiens_hsa030203.36308272
6Oxidative phosphorylation_Homo sapiens_hsa001902.79550255
7Parkinsons disease_Homo sapiens_hsa050122.73538186
8Spliceosome_Homo sapiens_hsa030402.55075066
9Protein export_Homo sapiens_hsa030602.47929477
10Regulation of autophagy_Homo sapiens_hsa041402.17730101
11RNA transport_Homo sapiens_hsa030132.02931881
12Huntingtons disease_Homo sapiens_hsa050161.93068965
13Folate biosynthesis_Homo sapiens_hsa007901.90279776
14Primary immunodeficiency_Homo sapiens_hsa053401.87389920
15Graft-versus-host disease_Homo sapiens_hsa053321.83013489
16DNA replication_Homo sapiens_hsa030301.78547612
17Mismatch repair_Homo sapiens_hsa034301.77439651
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.70303861
19Base excision repair_Homo sapiens_hsa034101.69724196
20mRNA surveillance pathway_Homo sapiens_hsa030151.63902650
21Pyrimidine metabolism_Homo sapiens_hsa002401.59731529
22Homologous recombination_Homo sapiens_hsa034401.57544541
23Allograft rejection_Homo sapiens_hsa053301.56072508
24RNA degradation_Homo sapiens_hsa030181.55444902
25Autoimmune thyroid disease_Homo sapiens_hsa053201.53450826
26Sulfur metabolism_Homo sapiens_hsa009201.49653407
27Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.48110371
28Antigen processing and presentation_Homo sapiens_hsa046121.46604696
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.45572944
30Cell cycle_Homo sapiens_hsa041101.45470387
31Cardiac muscle contraction_Homo sapiens_hsa042601.45415877
32Fanconi anemia pathway_Homo sapiens_hsa034601.42611880
33Alzheimers disease_Homo sapiens_hsa050101.40434606
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.23912695
35Nucleotide excision repair_Homo sapiens_hsa034201.23456251
36Taste transduction_Homo sapiens_hsa047421.19861739
37Asthma_Homo sapiens_hsa053101.17776687
38Type I diabetes mellitus_Homo sapiens_hsa049401.08383058
39Oocyte meiosis_Homo sapiens_hsa041141.07474232
40Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.05532118
41Purine metabolism_Homo sapiens_hsa002301.01796845
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.00101167
43Intestinal immune network for IgA production_Homo sapiens_hsa046720.98606974
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.96790308
45Hematopoietic cell lineage_Homo sapiens_hsa046400.92390662
46Propanoate metabolism_Homo sapiens_hsa006400.91941762
47Caffeine metabolism_Homo sapiens_hsa002320.91537216
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90747960
49SNARE interactions in vesicular transport_Homo sapiens_hsa041300.90651858
50p53 signaling pathway_Homo sapiens_hsa041150.89725580
51Ovarian steroidogenesis_Homo sapiens_hsa049130.88596885
52Non-homologous end-joining_Homo sapiens_hsa034500.87409377
53Epstein-Barr virus infection_Homo sapiens_hsa051690.82624053
54Fatty acid elongation_Homo sapiens_hsa000620.82021424
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80934825
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80894545
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.79756366
58Steroid biosynthesis_Homo sapiens_hsa001000.71991300
59Olfactory transduction_Homo sapiens_hsa047400.70743575
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70740225
61Phototransduction_Homo sapiens_hsa047440.64704227
62Linoleic acid metabolism_Homo sapiens_hsa005910.61890554
63Rheumatoid arthritis_Homo sapiens_hsa053230.59635371
64Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.57964592
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57051427
66Pyruvate metabolism_Homo sapiens_hsa006200.56303108
67Chemical carcinogenesis_Homo sapiens_hsa052040.55445738
68Systemic lupus erythematosus_Homo sapiens_hsa053220.52921151
69Herpes simplex infection_Homo sapiens_hsa051680.50311946
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.48507714
71Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.46394848
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45698475
73Metabolic pathways_Homo sapiens_hsa011000.45311910
74Fatty acid biosynthesis_Homo sapiens_hsa000610.43153545
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42894518
76Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.42285202
77Retinol metabolism_Homo sapiens_hsa008300.41433313
78Nitrogen metabolism_Homo sapiens_hsa009100.40934078
79Measles_Homo sapiens_hsa051620.39852737
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39309249
81Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.37193479
82Viral carcinogenesis_Homo sapiens_hsa052030.36013183
83Peroxisome_Homo sapiens_hsa041460.35456669
84One carbon pool by folate_Homo sapiens_hsa006700.35327967
85Legionellosis_Homo sapiens_hsa051340.33967878
86T cell receptor signaling pathway_Homo sapiens_hsa046600.32162333
87Vitamin digestion and absorption_Homo sapiens_hsa049770.30287941
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.30173429
89Serotonergic synapse_Homo sapiens_hsa047260.27618293
90Mineral absorption_Homo sapiens_hsa049780.27212464
91Jak-STAT signaling pathway_Homo sapiens_hsa046300.26610255
92NF-kappa B signaling pathway_Homo sapiens_hsa040640.25448581
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.23604592
94Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.23544897
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.23502271
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23472413
97TGF-beta signaling pathway_Homo sapiens_hsa043500.19000058
98Collecting duct acid secretion_Homo sapiens_hsa049660.18966301
99Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.16216122
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.14900815

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