HNRNPA3P7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sequestering of actin monomers (GO:0042989)4.64206859
2neural tube formation (GO:0001841)4.54657181
3mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.17034505
4protein neddylation (GO:0045116)4.16421709
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.15744832
6ATP synthesis coupled proton transport (GO:0015986)4.15744832
7nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.15414676
8exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.05516858
9proteasome assembly (GO:0043248)4.05386194
10DNA deamination (GO:0045006)4.02999894
11mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.97716457
12GPI anchor metabolic process (GO:0006505)3.97225370
13GPI anchor biosynthetic process (GO:0006506)3.90974572
14mitochondrial respiratory chain complex I assembly (GO:0032981)3.64656084
15NADH dehydrogenase complex assembly (GO:0010257)3.64656084
16mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.64656084
17organelle disassembly (GO:1903008)3.58663958
18chaperone-mediated protein transport (GO:0072321)3.58102579
19platelet dense granule organization (GO:0060155)3.57069324
20protein complex biogenesis (GO:0070271)3.52409998
21cullin deneddylation (GO:0010388)3.51933278
22RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.46430878
23tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.46430878
24protein prenylation (GO:0018342)3.45181844
25prenylation (GO:0097354)3.45181844
26ribonucleoprotein complex disassembly (GO:0032988)3.45007907
27RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.39520909
28preassembly of GPI anchor in ER membrane (GO:0016254)3.35579474
29nonmotile primary cilium assembly (GO:0035058)3.31966971
30DNA double-strand break processing (GO:0000729)3.30208951
31aldehyde catabolic process (GO:0046185)3.28429695
32negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.27434676
33mitochondrial respiratory chain complex assembly (GO:0033108)3.23896803
34negative regulation of heart rate (GO:0010459)3.23189845
35establishment of protein localization to mitochondrial membrane (GO:0090151)3.17059944
36GTP biosynthetic process (GO:0006183)3.14583201
37respiratory chain complex IV assembly (GO:0008535)3.13127733
38axoneme assembly (GO:0035082)3.13042943
39respiratory electron transport chain (GO:0022904)3.08237863
40electron transport chain (GO:0022900)3.06932638
41base-excision repair, AP site formation (GO:0006285)3.06162770
42cornea development in camera-type eye (GO:0061303)3.02555756
43CENP-A containing nucleosome assembly (GO:0034080)3.01884681
44chromatin remodeling at centromere (GO:0031055)3.01630481
45protein deneddylation (GO:0000338)3.01612454
46glycolipid biosynthetic process (GO:0009247)3.00256725
47C-terminal protein lipidation (GO:0006501)2.98621215
48water-soluble vitamin biosynthetic process (GO:0042364)2.97750341
49mannosylation (GO:0097502)2.96798885
50DNA damage response, detection of DNA damage (GO:0042769)2.96390710
51regulation of cellular amino acid metabolic process (GO:0006521)2.96355239
52peptidyl-histidine modification (GO:0018202)2.96163241
53cellular ketone body metabolic process (GO:0046950)2.95773097
54histone H2A acetylation (GO:0043968)2.95612900
55regulation of cilium movement (GO:0003352)2.92285729
56regulation of development, heterochronic (GO:0040034)2.91829936
57positive regulation of mitochondrial fission (GO:0090141)2.90375218
58epithelial cilium movement (GO:0003351)2.90319292
59DNA catabolic process, exonucleolytic (GO:0000738)2.87753098
60intraciliary transport (GO:0042073)2.85817711
61histone mRNA metabolic process (GO:0008334)2.82654803
62positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.81393612
63cytochrome complex assembly (GO:0017004)2.77703926
64C-terminal protein amino acid modification (GO:0018410)2.76958027
65L-fucose metabolic process (GO:0042354)2.76529987
66L-fucose catabolic process (GO:0042355)2.76529987
67fucose catabolic process (GO:0019317)2.76529987
68negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.75836765
69negative regulation of transcription regulatory region DNA binding (GO:2000678)2.74631943
70positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.73047832
71mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.73047832
72serotonin receptor signaling pathway (GO:0007210)2.72818945
73ubiquinone metabolic process (GO:0006743)2.72021608
74positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.71427313
75protein polyglutamylation (GO:0018095)2.68369786
76left/right axis specification (GO:0070986)2.68258537
77cilium morphogenesis (GO:0060271)2.67461725
78embryonic epithelial tube formation (GO:0001838)2.65043277
79purine nucleoside triphosphate biosynthetic process (GO:0009145)2.64727307
80protein localization to cilium (GO:0061512)2.64417900
81resolution of meiotic recombination intermediates (GO:0000712)2.64240262
82spliceosomal complex assembly (GO:0000245)2.63953845
83somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.63855644
84isotype switching (GO:0045190)2.63855644
85somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.63855644
86ketone body metabolic process (GO:1902224)2.62577939
87DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.61029847
88spliceosomal snRNP assembly (GO:0000387)2.59573835
89positive regulation of oligodendrocyte differentiation (GO:0048714)2.59390148
90signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.59021653
91signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.59021653
92signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.59021653
93synapsis (GO:0007129)2.58472172
94detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.57183255
95purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.55755621
96rRNA modification (GO:0000154)2.53942332
97signal transduction involved in cell cycle checkpoint (GO:0072395)2.52652207
98ubiquinone biosynthetic process (GO:0006744)2.52586173
99signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.51655003
100intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.51655003

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human3.82442549
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.59088390
3ZNF274_21170338_ChIP-Seq_K562_Hela3.20737338
4IGF1R_20145208_ChIP-Seq_DFB_Human3.02944810
5VDR_22108803_ChIP-Seq_LS180_Human3.01621836
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.96486842
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.95978049
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.88265865
9TAF15_26573619_Chip-Seq_HEK293_Human2.67800970
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.51440135
11EWS_26573619_Chip-Seq_HEK293_Human2.50944484
12ELK1_19687146_ChIP-ChIP_HELA_Human2.50463394
13VDR_23849224_ChIP-Seq_CD4+_Human2.28934406
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.21301404
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.13404693
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.13208770
17FUS_26573619_Chip-Seq_HEK293_Human2.11863186
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.07340989
19ETS1_20019798_ChIP-Seq_JURKAT_Human1.96193879
20P300_19829295_ChIP-Seq_ESCs_Human1.95594976
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.94883277
22CTBP2_25329375_ChIP-Seq_LNCAP_Human1.89628864
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.84558690
24FOXP3_21729870_ChIP-Seq_TREG_Human1.82384336
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.80373694
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.72617047
27CREB1_15753290_ChIP-ChIP_HEK293T_Human1.70742695
28PADI4_21655091_ChIP-ChIP_MCF-7_Human1.68908852
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.68480741
30MYC_18940864_ChIP-ChIP_HL60_Human1.66313553
31SRF_21415370_ChIP-Seq_HL-1_Mouse1.61770003
32POU5F1_16153702_ChIP-ChIP_HESCs_Human1.61263391
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.60480544
34GBX2_23144817_ChIP-Seq_PC3_Human1.59215626
35EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.56203323
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.56001438
37PCGF2_27294783_Chip-Seq_NPCs_Mouse1.54708901
38MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.53049789
39IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.50521366
40CBP_20019798_ChIP-Seq_JUKART_Human1.50521366
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46904606
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.45106685
43ER_23166858_ChIP-Seq_MCF-7_Human1.41379392
44MYC_18555785_ChIP-Seq_MESCs_Mouse1.38949861
45TP53_22573176_ChIP-Seq_HFKS_Human1.35865318
46SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31933444
47GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.31377893
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31206980
49SOX2_19829295_ChIP-Seq_ESCs_Human1.30694825
50NANOG_19829295_ChIP-Seq_ESCs_Human1.30694825
51GABP_19822575_ChIP-Seq_HepG2_Human1.29209854
52EZH2_27294783_Chip-Seq_NPCs_Mouse1.28779704
53GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.28581925
54HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.28377395
55FOXA1_27270436_Chip-Seq_PROSTATE_Human1.28192702
56FOXA1_25329375_ChIP-Seq_VCAP_Human1.28192702
57E2F4_17652178_ChIP-ChIP_JURKAT_Human1.28087816
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27901692
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26361026
60NFE2_27457419_Chip-Seq_LIVER_Mouse1.23304178
61DCP1A_22483619_ChIP-Seq_HELA_Human1.21963984
62AR_20517297_ChIP-Seq_VCAP_Human1.21332468
63PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.19636797
64FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.19411237
65IRF1_19129219_ChIP-ChIP_H3396_Human1.19281076
66RNF2_27304074_Chip-Seq_NSC_Mouse1.17865650
67KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16881995
68CBX2_27304074_Chip-Seq_ESCs_Mouse1.14482811
69CRX_20693478_ChIP-Seq_RETINA_Mouse1.13130723
70FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09682197
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09142779
72RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08484487
73HTT_18923047_ChIP-ChIP_STHdh_Human1.08421824
74NANOG_16153702_ChIP-ChIP_HESCs_Human1.08088872
75EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06623219
76CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.05721917
77ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05126617
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04432520
79TAL1_26923725_Chip-Seq_HPCs_Mouse1.03030384
80TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02454062
81E2F1_18555785_ChIP-Seq_MESCs_Mouse1.02417217
82TCF4_22108803_ChIP-Seq_LS180_Human1.01326770
83CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01007025
84NCOR_22424771_ChIP-Seq_293T_Human1.00670223
85SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00178018
86LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99690569
87TTF2_22483619_ChIP-Seq_HELA_Human0.99244199
88ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.99095774
89P53_22387025_ChIP-Seq_ESCs_Mouse0.98397463
90EZH2_22144423_ChIP-Seq_EOC_Human0.98145693
91NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.98143647
92HOXB4_20404135_ChIP-ChIP_EML_Mouse0.97980357
93AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96668831
94SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.96385104
95NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96048827
96FLI1_21867929_ChIP-Seq_TH2_Mouse0.95472082
97BMI1_23680149_ChIP-Seq_NPCS_Mouse0.95169566
98AR_25329375_ChIP-Seq_VCAP_Human0.94423050
99SMAD4_21799915_ChIP-Seq_A2780_Human0.94203767
100NANOG_18555785_Chip-Seq_ESCs_Mouse0.93902666

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006072_abnormal_retinal_apoptosis3.37631573
2MP0002102_abnormal_ear_morphology3.16295596
3MP0000372_irregular_coat_pigmentation3.14964057
4MP0003880_abnormal_central_pattern3.09182606
5MP0004147_increased_porphyrin_level2.85912295
6MP0008877_abnormal_DNA_methylation2.61520772
7MP0001984_abnormal_olfaction2.55131332
8MP0005253_abnormal_eye_physiology2.45039722
9MP0006292_abnormal_olfactory_placode2.30368554
10MP0008995_early_reproductive_senescence2.29666264
11MP0003787_abnormal_imprinting2.28523556
12MP0008789_abnormal_olfactory_epithelium2.24383169
13MP0003011_delayed_dark_adaptation2.05684841
14MP0003806_abnormal_nucleotide_metabolis2.00629621
15MP0005499_abnormal_olfactory_system1.96900497
16MP0005394_taste/olfaction_phenotype1.96900497
17MP0006276_abnormal_autonomic_nervous1.81791108
18MP0002234_abnormal_pharynx_morphology1.81135666
19MP0001529_abnormal_vocalization1.81038387
20MP0008058_abnormal_DNA_repair1.80981393
21MP0008875_abnormal_xenobiotic_pharmacok1.79778539
22MP0005551_abnormal_eye_electrophysiolog1.79588623
23MP0003122_maternal_imprinting1.72192743
24MP0002653_abnormal_ependyma_morphology1.71677798
25MP0004142_abnormal_muscle_tone1.67335820
26MP0005645_abnormal_hypothalamus_physiol1.65954903
27MP0003136_yellow_coat_color1.65305613
28MP0001986_abnormal_taste_sensitivity1.62102909
29MP0003195_calcinosis1.60940580
30MP0004133_heterotaxia1.58360802
31MP0004145_abnormal_muscle_electrophysio1.57245805
32MP0002751_abnormal_autonomic_nervous1.56966006
33MP0005084_abnormal_gallbladder_morpholo1.54418038
34MP0002938_white_spotting1.54413298
35MP0005646_abnormal_pituitary_gland1.52742762
36MP0003718_maternal_effect1.51737934
37MP0009697_abnormal_copulation1.49141799
38MP0001764_abnormal_homeostasis1.48551506
39MP0005075_abnormal_melanosome_morpholog1.47509903
40MP0001835_abnormal_antigen_presentation1.42428230
41MP0008872_abnormal_physiological_respon1.41343680
42MP0000516_abnormal_urinary_system1.39982674
43MP0005367_renal/urinary_system_phenotyp1.39982674
44MP0010386_abnormal_urinary_bladder1.39538541
45MP0008961_abnormal_basal_metabolism1.38745923
46MP0002736_abnormal_nociception_after1.32572816
47MP0006054_spinal_hemorrhage1.32424713
48MP0002837_dystrophic_cardiac_calcinosis1.30614340
49MP0000049_abnormal_middle_ear1.30555558
50MP0004885_abnormal_endolymph1.27059181
51MP0003121_genomic_imprinting1.25529606
52MP0004782_abnormal_surfactant_physiolog1.22941178
53MP0001905_abnormal_dopamine_level1.20587553
54MP0000631_abnormal_neuroendocrine_gland1.14900336
55MP0003567_abnormal_fetal_cardiomyocyte1.11467724
56MP0003786_premature_aging1.10874209
57MP0001293_anophthalmia1.07901454
58MP0004215_abnormal_myocardial_fiber1.06188112
59MP0005391_vision/eye_phenotype1.06088291
60MP0009745_abnormal_behavioral_response1.05775417
61MP0002272_abnormal_nervous_system1.04409589
62MP0001968_abnormal_touch/_nociception1.01798278
63MP0002638_abnormal_pupillary_reflex0.96573839
64MP0005195_abnormal_posterior_eye0.96302705
65MP0003137_abnormal_impulse_conducting0.94655084
66MP0003937_abnormal_limbs/digits/tail_de0.94366646
67MP0002090_abnormal_vision0.94216886
68MP0001485_abnormal_pinna_reflex0.91341312
69MP0009764_decreased_sensitivity_to0.91187095
70MP0000427_abnormal_hair_cycle0.90370780
71MP0005085_abnormal_gallbladder_physiolo0.90253264
72MP0001486_abnormal_startle_reflex0.89797854
73MP0005167_abnormal_blood-brain_barrier0.88928419
74MP0003186_abnormal_redox_activity0.87382664
75MP0003119_abnormal_digestive_system0.84053822
76MP0006036_abnormal_mitochondrial_physio0.80116781
77MP0002752_abnormal_somatic_nervous0.79150611
78MP0004484_altered_response_of0.78686629
79MP0000647_abnormal_sebaceous_gland0.78323478
80MP0002557_abnormal_social/conspecific_i0.78292942
81MP0002572_abnormal_emotion/affect_behav0.77758833
82MP0002282_abnormal_trachea_morphology0.77469745
83MP0005332_abnormal_amino_acid0.76607764
84MP0010094_abnormal_chromosome_stability0.76504518
85MP0000026_abnormal_inner_ear0.74729358
86MP0006035_abnormal_mitochondrial_morpho0.74312771
87MP0001970_abnormal_pain_threshold0.73935372
88MP0003221_abnormal_cardiomyocyte_apopto0.73922204
89MP0000653_abnormal_sex_gland0.73298479
90MP0001929_abnormal_gametogenesis0.70760602
91MP0002233_abnormal_nose_morphology0.69822695
92MP0005410_abnormal_fertilization0.68937639
93MP0002095_abnormal_skin_pigmentation0.68837499
94MP0008932_abnormal_embryonic_tissue0.68829592
95MP0005389_reproductive_system_phenotype0.68816394
96MP0001963_abnormal_hearing_physiology0.68811703
97MP0001119_abnormal_female_reproductive0.68776574
98MP0003646_muscle_fatigue0.68361082
99MP0000778_abnormal_nervous_system0.67245702
100MP0004085_abnormal_heartbeat0.66167149

Predicted human phenotypes

RankGene SetZ-score
1True hermaphroditism (HP:0010459)4.37707807
2Pancreatic cysts (HP:0001737)4.21981191
3Pancreatic fibrosis (HP:0100732)4.13081948
4Mitochondrial inheritance (HP:0001427)3.62920173
5Lipid accumulation in hepatocytes (HP:0006561)3.61283997
6Increased hepatocellular lipid droplets (HP:0006565)3.58233424
73-Methylglutaconic aciduria (HP:0003535)3.57355096
8Absent rod-and cone-mediated responses on ERG (HP:0007688)3.55427590
9Acute necrotizing encephalopathy (HP:0006965)3.53028449
10Increased serum pyruvate (HP:0003542)3.45617631
11Increased CSF lactate (HP:0002490)3.33424683
12Nephronophthisis (HP:0000090)3.18706428
13Hepatocellular necrosis (HP:0001404)3.18480457
14Abnormality of midbrain morphology (HP:0002418)3.14821607
15Molar tooth sign on MRI (HP:0002419)3.14821607
16Acute encephalopathy (HP:0006846)3.11382437
17Hepatic necrosis (HP:0002605)3.10365672
18Progressive macrocephaly (HP:0004481)3.10310296
19Abnormality of alanine metabolism (HP:0010916)3.04895253
20Hyperalaninemia (HP:0003348)3.04895253
21Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.04895253
22Abolished electroretinogram (ERG) (HP:0000550)2.98281348
23Attenuation of retinal blood vessels (HP:0007843)2.97835498
24Abnormal mitochondria in muscle tissue (HP:0008316)2.93053198
25Thyroid-stimulating hormone excess (HP:0002925)2.89633333
26Medial flaring of the eyebrow (HP:0010747)2.86283512
27Abnormality of glycolysis (HP:0004366)2.85060142
28Colon cancer (HP:0003003)2.73800326
29Abnormal rod and cone electroretinograms (HP:0008323)2.69718386
30Renal Fanconi syndrome (HP:0001994)2.68166233
31Hypothermia (HP:0002045)2.66674784
32Decreased central vision (HP:0007663)2.65433394
33Exertional dyspnea (HP:0002875)2.61923112
34Anencephaly (HP:0002323)2.53581784
35Occipital encephalocele (HP:0002085)2.53089678
36Cystic liver disease (HP:0006706)2.51705521
37Congenital primary aphakia (HP:0007707)2.49020496
38Sclerocornea (HP:0000647)2.47318724
39Methylmalonic acidemia (HP:0002912)2.45801745
40Type I transferrin isoform profile (HP:0003642)2.43010408
41Aplasia/Hypoplasia of the tongue (HP:0010295)2.42879016
42Abnormal protein glycosylation (HP:0012346)2.39699820
43Abnormal glycosylation (HP:0012345)2.39699820
44Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.39699820
45Abnormal protein N-linked glycosylation (HP:0012347)2.39699820
46Hyperglycinemia (HP:0002154)2.39647970
47Microvesicular hepatic steatosis (HP:0001414)2.38733433
48Gait imbalance (HP:0002141)2.38190956
49Short tibia (HP:0005736)2.38017233
50Abnormality of the renal medulla (HP:0100957)2.36777373
51Hypoproteinemia (HP:0003075)2.36176362
52Aplasia/Hypoplasia of the tibia (HP:0005772)2.32123017
53Optic disc pallor (HP:0000543)2.32048350
54Nephrogenic diabetes insipidus (HP:0009806)2.27504531
55Male pseudohermaphroditism (HP:0000037)2.26142469
56Cerebral edema (HP:0002181)2.25509774
57Increased serum lactate (HP:0002151)2.24261063
58Congenital hepatic fibrosis (HP:0002612)2.24151007
59Glycosuria (HP:0003076)2.22633983
60Abnormality of urine glucose concentration (HP:0011016)2.22633983
61Intestinal atresia (HP:0011100)2.20344068
62Congenital stationary night blindness (HP:0007642)2.19475983
63Lactic acidosis (HP:0003128)2.18736476
64Postaxial foot polydactyly (HP:0001830)2.18528838
65Supernumerary spleens (HP:0009799)2.13780644
66Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.13512914
67Abnormality of serum amino acid levels (HP:0003112)2.08049001
68Thyroiditis (HP:0100646)2.01569909
69Genital tract atresia (HP:0001827)1.98917122
70Vaginal atresia (HP:0000148)1.98089284
71Stenosis of the external auditory canal (HP:0000402)1.98041388
72Methylmalonic aciduria (HP:0012120)1.96604200
73Constricted visual fields (HP:0001133)1.94601137
74Postaxial hand polydactyly (HP:0001162)1.93431005
75Increased intramyocellular lipid droplets (HP:0012240)1.92943478
76Respiratory failure (HP:0002878)1.92869360
77Preaxial hand polydactyly (HP:0001177)1.89944132
78Generalized aminoaciduria (HP:0002909)1.87813408
79Abnormality of the labia minora (HP:0012880)1.87292109
80Abnormal respiratory epithelium morphology (HP:0012253)1.86665051
81Abnormal respiratory motile cilium morphology (HP:0005938)1.86665051
82CNS demyelination (HP:0007305)1.85569276
83Reduced antithrombin III activity (HP:0001976)1.82455410
84Renal cortical cysts (HP:0000803)1.81526081
85Long nose (HP:0003189)1.79939008
86Dandy-Walker malformation (HP:0001305)1.79566250
87Median cleft lip (HP:0000161)1.79476076
88Decreased electroretinogram (ERG) amplitude (HP:0000654)1.79034213
89Increased corneal curvature (HP:0100692)1.78453191
90Keratoconus (HP:0000563)1.78453191
91Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.77676474
92Pendular nystagmus (HP:0012043)1.77614284
93Abnormal ciliary motility (HP:0012262)1.77605254
94Abnormality of dicarboxylic acid metabolism (HP:0010995)1.75930928
95Dicarboxylic aciduria (HP:0003215)1.75930928
96Progressive inability to walk (HP:0002505)1.75150700
97Abnormality of the anterior horn cell (HP:0006802)1.74146627
98Degeneration of anterior horn cells (HP:0002398)1.74146627
99Type II lissencephaly (HP:0007260)1.72005800
100Decreased testicular size (HP:0008734)1.69881801

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K24.40703970
2ERBB32.83117543
3TRIM282.74944328
4ZAK2.66866842
5CDK192.58733100
6BCR2.54346811
7MAP2K72.47302066
8FRK2.45355583
9MAP3K42.44903076
10MKNK12.35566629
11BMPR22.25537357
12BUB12.13416640
13WNK32.01713643
14BMPR1B1.98860802
15NUAK11.94400172
16EIF2AK31.94145051
17SRPK11.89227165
18TLK11.77367111
19VRK21.72137014
20EPHA41.64042032
21ADRBK21.61229079
22VRK11.61161995
23GRK11.50981448
24UHMK11.39667310
25MAPK131.36456003
26RPS6KA41.35472250
27CSNK1G31.33674006
28PLK31.28952687
29MST41.26400783
30BCKDK1.20894364
31CSNK1G21.20470225
32TIE11.20445071
33FLT31.20352675
34SIK31.19110372
35DYRK21.18996611
36TEC1.16641475
37INSRR1.15857653
38EPHA31.15627435
39TNIK1.11968166
40CSNK1A1L1.11469217
41TXK1.07476545
42DYRK31.05205455
43CSNK1G11.04414687
44RPS6KA51.00333974
45TSSK60.99628679
46CCNB10.91684475
47MKNK20.90106596
48STK160.89381425
49TAOK30.88006185
50PLK20.87702479
51KIT0.86488474
52MAP3K120.81889303
53PINK10.80364506
54CAMKK20.78430254
55PLK40.71990239
56MINK10.70259859
57OXSR10.68609045
58PAK30.68259985
59AURKB0.66392898
60PRKCE0.62187998
61EIF2AK20.62107030
62ITK0.58785806
63NEK20.58719023
64ATR0.57018153
65PLK10.56684857
66NEK10.56097546
67EIF2AK10.54555484
68MATK0.54436854
69IRAK20.53862382
70TNK20.53375366
71WNK40.51729798
72PBK0.50769122
73PTK2B0.47156957
74CSNK2A10.47120522
75STK40.47107359
76PKN10.46758199
77BTK0.44557468
78TAF10.43406442
79OBSCN0.42043861
80FER0.41640532
81MYLK0.40907527
82CSNK1A10.39182953
83WEE10.35527553
84PRKG10.35175678
85MAP2K40.34551398
86IGF1R0.34534011
87EPHB20.34211623
88ACVR1B0.33637263
89PRKACA0.33001189
90FGFR20.32075298
91ATM0.30889867
92PASK0.30781512
93ABL10.30720588
94CAMK2A0.30568537
95KDR0.30270170
96MARK10.30267180
97CAMK40.30099145
98TGFBR10.29262066
99CSNK2A20.29117106
100DAPK20.28215860

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.51883540
2Proteasome_Homo sapiens_hsa030503.50681725
3Protein export_Homo sapiens_hsa030603.37195187
4Asthma_Homo sapiens_hsa053103.32689992
5Oxidative phosphorylation_Homo sapiens_hsa001903.16317651
6Parkinsons disease_Homo sapiens_hsa050122.67886051
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.39164968
8Propanoate metabolism_Homo sapiens_hsa006402.14094221
9Butanoate metabolism_Homo sapiens_hsa006502.12947162
10Allograft rejection_Homo sapiens_hsa053302.10796587
11Intestinal immune network for IgA production_Homo sapiens_hsa046721.93861755
12Type I diabetes mellitus_Homo sapiens_hsa049401.93594235
13RNA polymerase_Homo sapiens_hsa030201.93260433
14Graft-versus-host disease_Homo sapiens_hsa053321.91710669
15Autoimmune thyroid disease_Homo sapiens_hsa053201.87879142
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.78919086
17Basal transcription factors_Homo sapiens_hsa030221.76223805
18Huntingtons disease_Homo sapiens_hsa050161.71001191
19Homologous recombination_Homo sapiens_hsa034401.57027529
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.56868363
21RNA degradation_Homo sapiens_hsa030181.53228441
22Alzheimers disease_Homo sapiens_hsa050101.50456542
23Ribosome_Homo sapiens_hsa030101.50262701
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.43049580
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.42131900
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.40878877
27Spliceosome_Homo sapiens_hsa030401.40035270
28Phototransduction_Homo sapiens_hsa047441.38519859
29Non-homologous end-joining_Homo sapiens_hsa034501.34839811
30Base excision repair_Homo sapiens_hsa034101.31839536
31Steroid biosynthesis_Homo sapiens_hsa001001.26490815
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.22981888
33Nitrogen metabolism_Homo sapiens_hsa009101.22734559
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.13799575
35Rheumatoid arthritis_Homo sapiens_hsa053231.13373751
36Linoleic acid metabolism_Homo sapiens_hsa005911.11619550
37Caffeine metabolism_Homo sapiens_hsa002321.09382000
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.09093175
39Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.08355970
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.07243262
41One carbon pool by folate_Homo sapiens_hsa006701.06348621
42Collecting duct acid secretion_Homo sapiens_hsa049661.05184715
43RNA transport_Homo sapiens_hsa030131.04684882
44Peroxisome_Homo sapiens_hsa041461.02383302
45Fanconi anemia pathway_Homo sapiens_hsa034601.01911911
46Pyrimidine metabolism_Homo sapiens_hsa002400.96843568
47Sulfur metabolism_Homo sapiens_hsa009200.93889121
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93748683
49Tryptophan metabolism_Homo sapiens_hsa003800.91809359
50Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.90208280
51Antigen processing and presentation_Homo sapiens_hsa046120.86703575
52Purine metabolism_Homo sapiens_hsa002300.85082515
53Cardiac muscle contraction_Homo sapiens_hsa042600.84849316
54Regulation of autophagy_Homo sapiens_hsa041400.84023456
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82753559
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81101609
57Pyruvate metabolism_Homo sapiens_hsa006200.79939729
58Systemic lupus erythematosus_Homo sapiens_hsa053220.77415512
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75765236
60Retinol metabolism_Homo sapiens_hsa008300.75764698
61Mismatch repair_Homo sapiens_hsa034300.75087986
62Fatty acid elongation_Homo sapiens_hsa000620.72755458
63beta-Alanine metabolism_Homo sapiens_hsa004100.72520941
64Glutathione metabolism_Homo sapiens_hsa004800.72097153
65Metabolic pathways_Homo sapiens_hsa011000.72082543
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71225636
67GABAergic synapse_Homo sapiens_hsa047270.70312521
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.69167466
69Nicotine addiction_Homo sapiens_hsa050330.66091825
70Nucleotide excision repair_Homo sapiens_hsa034200.63034555
71Arachidonic acid metabolism_Homo sapiens_hsa005900.62872054
72Olfactory transduction_Homo sapiens_hsa047400.61233247
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60736288
74Chemical carcinogenesis_Homo sapiens_hsa052040.59304128
75Staphylococcus aureus infection_Homo sapiens_hsa051500.59069203
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56543024
77Ether lipid metabolism_Homo sapiens_hsa005650.55643184
78Fatty acid degradation_Homo sapiens_hsa000710.53800319
79Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.53438669
80Serotonergic synapse_Homo sapiens_hsa047260.52148310
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48933200
82Taste transduction_Homo sapiens_hsa047420.48468700
83Viral myocarditis_Homo sapiens_hsa054160.46916767
84Fat digestion and absorption_Homo sapiens_hsa049750.46853155
85Maturity onset diabetes of the young_Homo sapiens_hsa049500.46585934
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44097283
87Sulfur relay system_Homo sapiens_hsa041220.44090433
88Morphine addiction_Homo sapiens_hsa050320.42332841
892-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.39450553
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.38710376
91Folate biosynthesis_Homo sapiens_hsa007900.38688392
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38361628
93Circadian entrainment_Homo sapiens_hsa047130.37343737
94Drug metabolism - other enzymes_Homo sapiens_hsa009830.35739920
95Alcoholism_Homo sapiens_hsa050340.35738880
96Arginine and proline metabolism_Homo sapiens_hsa003300.34431084
97Biosynthesis of amino acids_Homo sapiens_hsa012300.34198740
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33125826
99Fatty acid metabolism_Homo sapiens_hsa012120.32512573
100Herpes simplex infection_Homo sapiens_hsa051680.32294412

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