HNRNPA1P9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sequestering of actin monomers (GO:0042989)5.85618503
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.14427628
3establishment of protein localization to mitochondrial membrane (GO:0090151)5.00582241
4ATP synthesis coupled proton transport (GO:0015986)4.73802684
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.73802684
6urate metabolic process (GO:0046415)4.67756704
7respiratory chain complex IV assembly (GO:0008535)4.46330677
8rRNA modification (GO:0000154)4.41882294
9rRNA methylation (GO:0031167)4.36586089
10mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.19538680
11viral transcription (GO:0019083)4.11872701
12translational termination (GO:0006415)4.07437293
13diacylglycerol metabolic process (GO:0046339)4.03992955
14ribosomal small subunit assembly (GO:0000028)3.92165835
15glycerol metabolic process (GO:0006071)3.88968992
16mannosylation (GO:0097502)3.77585914
17cotranslational protein targeting to membrane (GO:0006613)3.76182729
18SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.72973740
19ribosomal large subunit biogenesis (GO:0042273)3.67565456
20protein targeting to ER (GO:0045047)3.61542440
21heme transport (GO:0015886)3.61520982
22behavioral response to nicotine (GO:0035095)3.51821111
23serotonin receptor signaling pathway (GO:0007210)3.51131221
24attachment of spindle microtubules to kinetochore (GO:0008608)3.48826263
25respiratory electron transport chain (GO:0022904)3.43773647
26protein localization to endoplasmic reticulum (GO:0070972)3.43645648
27alditol metabolic process (GO:0019400)3.42611936
28establishment of protein localization to endoplasmic reticulum (GO:0072599)3.42053459
29electron transport chain (GO:0022900)3.41031427
30cytochrome complex assembly (GO:0017004)3.40962632
31inner mitochondrial membrane organization (GO:0007007)3.38169685
32translational elongation (GO:0006414)3.38137771
33phospholipid homeostasis (GO:0055091)3.37743129
34protein complex biogenesis (GO:0070271)3.35577502
35response to folic acid (GO:0051593)3.33828066
36chaperone-mediated protein transport (GO:0072321)3.31987685
37protein-cofactor linkage (GO:0018065)3.28346507
38DNA damage response, detection of DNA damage (GO:0042769)3.27378164
39mitochondrial respiratory chain complex assembly (GO:0033108)3.16768640
40nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.16615340
41exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.14023945
42phasic smooth muscle contraction (GO:0014821)3.06577034
43mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.05375576
44mitochondrial respiratory chain complex I assembly (GO:0032981)3.05375576
45NADH dehydrogenase complex assembly (GO:0010257)3.05375576
46fucose catabolic process (GO:0019317)3.04094437
47L-fucose metabolic process (GO:0042354)3.04094437
48L-fucose catabolic process (GO:0042355)3.04094437
49nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.04068930
50base-excision repair, AP site formation (GO:0006285)3.03777326
51protein neddylation (GO:0045116)2.96052574
52translational initiation (GO:0006413)2.95864095
53cellular protein complex disassembly (GO:0043624)2.94895708
54dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.93300323
55somatic hypermutation of immunoglobulin genes (GO:0016446)2.90744463
56somatic diversification of immune receptors via somatic mutation (GO:0002566)2.90744463
57lung secretory cell differentiation (GO:0061140)2.89946145
58oxidative phosphorylation (GO:0006119)2.88257090
59protein localization to kinetochore (GO:0034501)2.87807730
60ATP biosynthetic process (GO:0006754)2.86271652
61S-adenosylmethionine metabolic process (GO:0046500)2.84172301
62DNA deamination (GO:0045006)2.83733338
63viral life cycle (GO:0019058)2.82977363
64triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.81190233
65translation (GO:0006412)2.76345267
66regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.68241681
67grooming behavior (GO:0007625)2.64499924
68ribonucleoprotein complex disassembly (GO:0032988)2.63084782
69lactate metabolic process (GO:0006089)2.63044161
70purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.62867735
71heart field specification (GO:0003128)2.61737088
72secondary heart field specification (GO:0003139)2.61737088
73organelle disassembly (GO:1903008)2.61370330
74adult feeding behavior (GO:0008343)2.60900738
75purine nucleoside triphosphate biosynthetic process (GO:0009145)2.60510835
76retinal cone cell development (GO:0046549)2.57799851
77DNA double-strand break processing (GO:0000729)2.56874639
78low-density lipoprotein particle remodeling (GO:0034374)2.56574536
79cardiac right ventricle morphogenesis (GO:0003215)2.55580470
80proteasome assembly (GO:0043248)2.55506766
81nuclear-transcribed mRNA catabolic process (GO:0000956)2.51293300
82macromolecular complex disassembly (GO:0032984)2.51035792
83protein complex disassembly (GO:0043241)2.50116022
84intracellular protein transmembrane import (GO:0044743)2.48566609
85iron coordination entity transport (GO:1901678)2.47931889
86protein homotrimerization (GO:0070207)2.45973533
87transcription elongation from RNA polymerase III promoter (GO:0006385)2.43680155
88termination of RNA polymerase III transcription (GO:0006386)2.43680155
89purine-containing compound salvage (GO:0043101)2.41136730
90mRNA catabolic process (GO:0006402)2.40026437
91neuron fate determination (GO:0048664)2.39571997
92regulation of sarcomere organization (GO:0060297)2.38390821
93forebrain neuron differentiation (GO:0021879)2.38321661
94regulation of mitotic spindle checkpoint (GO:1903504)2.37739405
95regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.37739405
96pituitary gland development (GO:0021983)2.36395376
97hydrogen ion transmembrane transport (GO:1902600)2.36381933
98negative regulation of neurological system process (GO:0031645)2.34590435
99retinal ganglion cell axon guidance (GO:0031290)2.33087322
100tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.31308739

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.77523794
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.75882906
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.61113350
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.39173669
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.33393293
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.04843766
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.03913296
8VDR_22108803_ChIP-Seq_LS180_Human2.93653445
9ZNF274_21170338_ChIP-Seq_K562_Hela2.69586966
10TAF15_26573619_Chip-Seq_HEK293_Human2.62767342
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.54802973
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.42755108
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.40599039
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.38845518
15EWS_26573619_Chip-Seq_HEK293_Human2.35262497
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.31657790
17ELK1_19687146_ChIP-ChIP_HELA_Human2.12249397
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.09898858
19VDR_23849224_ChIP-Seq_CD4+_Human2.04172913
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.02801411
21SRF_21415370_ChIP-Seq_HL-1_Mouse1.97267439
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.96672936
23ZFP57_27257070_Chip-Seq_ESCs_Mouse1.94097738
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.87802827
25FOXP3_21729870_ChIP-Seq_TREG_Human1.85834622
26MYC_18555785_ChIP-Seq_MESCs_Mouse1.81328069
27POU3F2_20337985_ChIP-ChIP_501MEL_Human1.80132824
28IGF1R_20145208_ChIP-Seq_DFB_Human1.78351147
29SALL1_21062744_ChIP-ChIP_HESCs_Human1.75986934
30CREB1_15753290_ChIP-ChIP_HEK293T_Human1.74799273
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.72467720
32FUS_26573619_Chip-Seq_HEK293_Human1.71443182
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.59404446
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56896854
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54985084
36MYC_18940864_ChIP-ChIP_HL60_Human1.54029214
37TP53_22573176_ChIP-Seq_HFKS_Human1.50409123
38P300_19829295_ChIP-Seq_ESCs_Human1.47880199
39NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.41634458
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41259341
41POU5F1_16153702_ChIP-ChIP_HESCs_Human1.40682632
42TTF2_22483619_ChIP-Seq_HELA_Human1.36644557
43XRN2_22483619_ChIP-Seq_HELA_Human1.36643825
44GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.35936325
45IRF1_19129219_ChIP-ChIP_H3396_Human1.34256526
46PADI4_21655091_ChIP-ChIP_MCF-7_Human1.33138359
47CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.32898876
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.29460498
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.28532257
50CBP_20019798_ChIP-Seq_JUKART_Human1.23599732
51IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23599732
52ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22884768
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22639661
54TCF4_22108803_ChIP-Seq_LS180_Human1.20869362
55PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20797908
56ER_23166858_ChIP-Seq_MCF-7_Human1.19981190
57RNF2_27304074_Chip-Seq_NSC_Mouse1.19705463
58MYC_19079543_ChIP-ChIP_MESCs_Mouse1.18679403
59STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.18067732
60DCP1A_22483619_ChIP-Seq_HELA_Human1.17557869
61NANOG_19829295_ChIP-Seq_ESCs_Human1.16532788
62SOX2_19829295_ChIP-Seq_ESCs_Human1.16532788
63GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.15986993
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13525044
65TP63_19390658_ChIP-ChIP_HaCaT_Human1.11303620
66MYC_18358816_ChIP-ChIP_MESCs_Mouse1.09389803
67GBX2_23144817_ChIP-Seq_PC3_Human1.09190685
68FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.08686457
69POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.08482493
70SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08292099
71RBPJ_22232070_ChIP-Seq_NCS_Mouse1.08275672
72CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.07929847
73E2F4_17652178_ChIP-ChIP_JURKAT_Human1.06709483
74EZH2_27294783_Chip-Seq_NPCs_Mouse1.06537908
75NFE2_27457419_Chip-Seq_LIVER_Mouse1.05782703
76IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.03639627
77MYC_19030024_ChIP-ChIP_MESCs_Mouse1.02091888
78KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01427587
79SMAD3_21741376_ChIP-Seq_EPCs_Human1.00738107
80RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00697228
81YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99997951
82BCAT_22108803_ChIP-Seq_LS180_Human0.99649170
83FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99497079
84FOXA1_25329375_ChIP-Seq_VCAP_Human0.99497079
85AR_20517297_ChIP-Seq_VCAP_Human0.98096883
86KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97858132
87ELK1_22589737_ChIP-Seq_MCF10A_Human0.97341778
88FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.96416987
89PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.93806525
90TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93661794
91HOXB4_20404135_ChIP-ChIP_EML_Mouse0.93644619
92SOX2_16153702_ChIP-ChIP_HESCs_Human0.92296224
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90596929
94CBX2_27304074_Chip-Seq_ESCs_Mouse0.90528146
95TAL1_26923725_Chip-Seq_HPCs_Mouse0.89868300
96CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.88717097
97OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88565677
98AUTS2_25519132_ChIP-Seq_293T-REX_Human0.87910233
99ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86897202
100NANOG_18555785_Chip-Seq_ESCs_Mouse0.85354604

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level4.89395926
2MP0006072_abnormal_retinal_apoptosis3.62219695
3MP0006292_abnormal_olfactory_placode2.93405600
4MP0005084_abnormal_gallbladder_morpholo2.91782873
5MP0006276_abnormal_autonomic_nervous2.57733006
6MP0008995_early_reproductive_senescence2.55005710
7MP0008058_abnormal_DNA_repair2.48342700
8MP0005646_abnormal_pituitary_gland2.47165297
9MP0003011_delayed_dark_adaptation2.45457140
10MP0004133_heterotaxia2.34033411
11MP0000372_irregular_coat_pigmentation2.28763723
12MP0005551_abnormal_eye_electrophysiolog2.15575405
13MP0008877_abnormal_DNA_methylation2.14780041
14MP0005167_abnormal_blood-brain_barrier2.12667445
15MP0005253_abnormal_eye_physiology2.07286254
16MP0002938_white_spotting2.04359231
17MP0000631_abnormal_neuroendocrine_gland2.01032183
18MP0002736_abnormal_nociception_after1.93182604
19MP0001293_anophthalmia1.84533904
20MP0002254_reproductive_system_inflammat1.82539985
21MP0001764_abnormal_homeostasis1.80088269
22MP0002234_abnormal_pharynx_morphology1.72619524
23MP0005645_abnormal_hypothalamus_physiol1.72095539
24MP0003567_abnormal_fetal_cardiomyocyte1.71823963
25MP0003718_maternal_effect1.69812970
26MP0002277_abnormal_respiratory_mucosa1.55519713
27MP0001529_abnormal_vocalization1.55501425
28MP0001873_stomach_inflammation1.53851748
29MP0001968_abnormal_touch/_nociception1.51093458
30MP0005085_abnormal_gallbladder_physiolo1.49908889
31MP0002928_abnormal_bile_duct1.49377478
32MP0003195_calcinosis1.47786056
33MP0003880_abnormal_central_pattern1.44948171
34MP0001879_abnormal_lymphatic_vessel1.36286462
35MP0008872_abnormal_physiological_respon1.34852062
36MP0003786_premature_aging1.34743443
37MP0002751_abnormal_autonomic_nervous1.34037664
38MP0008961_abnormal_basal_metabolism1.33907105
39MP0001486_abnormal_startle_reflex1.32637279
40MP0003787_abnormal_imprinting1.32368680
41MP0003122_maternal_imprinting1.27601496
42MP0001501_abnormal_sleep_pattern1.25214972
43MP0002822_catalepsy1.23220259
44MP0004142_abnormal_muscle_tone1.17999168
45MP0003638_abnormal_response/metabolism_1.17285096
46MP0002876_abnormal_thyroid_physiology1.16817711
47MP0005391_vision/eye_phenotype1.15218587
48MP0006035_abnormal_mitochondrial_morpho1.13064013
49MP0009745_abnormal_behavioral_response1.08806190
50MP0002272_abnormal_nervous_system1.08018792
51MP0009379_abnormal_foot_pigmentation1.07069589
52MP0003693_abnormal_embryo_hatching1.06770553
53MP0002090_abnormal_vision1.06627080
54MP0003121_genomic_imprinting1.06099412
55MP0003111_abnormal_nucleus_morphology1.05517474
56MP0003186_abnormal_redox_activity1.01477864
57MP0002572_abnormal_emotion/affect_behav0.98307472
58MP0006036_abnormal_mitochondrial_physio0.96763687
59MP0004215_abnormal_myocardial_fiber0.96047761
60MP0005220_abnormal_exocrine_pancreas0.95467014
61MP0003119_abnormal_digestive_system0.94926641
62MP0005332_abnormal_amino_acid0.94556257
63MP0005075_abnormal_melanosome_morpholog0.93754285
64MP0002102_abnormal_ear_morphology0.93641279
65MP0000230_abnormal_systemic_arterial0.93497627
66MP0001905_abnormal_dopamine_level0.92591991
67MP0001944_abnormal_pancreas_morphology0.92320563
68MP0001440_abnormal_grooming_behavior0.89806020
69MP0001502_abnormal_circadian_rhythm0.89605768
70MP0003724_increased_susceptibility_to0.89037477
71MP0008789_abnormal_olfactory_epithelium0.86477590
72MP0000653_abnormal_sex_gland0.85784878
73MP0008775_abnormal_heart_ventricle0.83863596
74MP0010094_abnormal_chromosome_stability0.83021704
75MP0005408_hypopigmentation0.82697548
76MP0001661_extended_life_span0.81803580
77MP0005499_abnormal_olfactory_system0.81183222
78MP0005394_taste/olfaction_phenotype0.81183222
79MP0001986_abnormal_taste_sensitivity0.80772415
80MP0002638_abnormal_pupillary_reflex0.80062680
81MP0009697_abnormal_copulation0.79737645
82MP0002557_abnormal_social/conspecific_i0.79639727
83MP0002734_abnormal_mechanical_nocicepti0.79271209
84MP0002733_abnormal_thermal_nociception0.79166530
85MP0005195_abnormal_posterior_eye0.78020177
86MP0008875_abnormal_xenobiotic_pharmacok0.76774049
87MP0002693_abnormal_pancreas_physiology0.76508468
88MP0005671_abnormal_response_to0.74467568
89MP0001346_abnormal_lacrimal_gland0.72709402
90MP0001145_abnormal_male_reproductive0.72486824
91MP0002735_abnormal_chemical_nociception0.71885879
92MP0002210_abnormal_sex_determination0.71556247
93MP0005647_abnormal_sex_gland0.71417835
94MP0001970_abnormal_pain_threshold0.70599549
95MP0001929_abnormal_gametogenesis0.69584719
96MP0003137_abnormal_impulse_conducting0.69552805
97MP0004885_abnormal_endolymph0.69102689
98MP0000639_abnormal_adrenal_gland0.69071491
99MP0003283_abnormal_digestive_organ0.67793572
100MP0004019_abnormal_vitamin_homeostasis0.67116804

Predicted human phenotypes

RankGene SetZ-score
1Increased hepatocellular lipid droplets (HP:0006565)4.10523345
2Mitochondrial inheritance (HP:0001427)4.08585319
3Acute necrotizing encephalopathy (HP:0006965)4.02311682
4Progressive macrocephaly (HP:0004481)3.63246783
5Acute encephalopathy (HP:0006846)3.62903310
6Thyroid-stimulating hormone excess (HP:0002925)3.57569621
7Lipid accumulation in hepatocytes (HP:0006561)3.57460258
8Hepatocellular necrosis (HP:0001404)3.49332699
9Abnormal mitochondria in muscle tissue (HP:0008316)3.44529474
10Increased CSF lactate (HP:0002490)3.41178983
11Delayed CNS myelination (HP:0002188)3.37338538
12Congenital stationary night blindness (HP:0007642)3.24751400
13Renal Fanconi syndrome (HP:0001994)3.16825336
14Hepatic necrosis (HP:0002605)3.10987674
15Attenuation of retinal blood vessels (HP:0007843)3.07651480
16Stenosis of the external auditory canal (HP:0000402)2.96112575
17Decreased central vision (HP:0007663)2.95933148
18Hyperinsulinemic hypoglycemia (HP:0000825)2.88613853
19Reticulocytopenia (HP:0001896)2.81082668
20Type I transferrin isoform profile (HP:0003642)2.78022164
21Stomach cancer (HP:0012126)2.72783441
22Cerebral edema (HP:0002181)2.70513323
233-Methylglutaconic aciduria (HP:0003535)2.67070386
24Pancreatic fibrosis (HP:0100732)2.64126000
25Hypoglycemic seizures (HP:0002173)2.60701717
26Methylmalonic aciduria (HP:0012120)2.56259955
27Cerebellar dysplasia (HP:0007033)2.53981999
28Aplasia/Hypoplasia of the spleen (HP:0010451)2.53378584
29Methylmalonic acidemia (HP:0002912)2.52593028
30Congenital, generalized hypertrichosis (HP:0004540)2.52220131
31Pancreatic cysts (HP:0001737)2.51836666
32Macrocytic anemia (HP:0001972)2.45534539
33Pendular nystagmus (HP:0012043)2.45383800
34Intestinal atresia (HP:0011100)2.44577487
35Abnormal rod and cone electroretinograms (HP:0008323)2.42401886
36Absent rod-and cone-mediated responses on ERG (HP:0007688)2.41154365
37Abolished electroretinogram (ERG) (HP:0000550)2.40674795
38Hyperglycinemia (HP:0002154)2.40001654
39Autoimmune thrombocytopenia (HP:0001973)2.39631376
40Hypoglycemic coma (HP:0001325)2.38278141
41Medial flaring of the eyebrow (HP:0010747)2.37766551
42Abnormality of the labia minora (HP:0012880)2.33435078
43Hypothermia (HP:0002045)2.33230152
44Exertional dyspnea (HP:0002875)2.29796155
45Gout (HP:0001997)2.29173133
46Asplenia (HP:0001746)2.27124979
47Lactic acidosis (HP:0003128)2.27065452
48Increased intramyocellular lipid droplets (HP:0012240)2.26414342
49Molar tooth sign on MRI (HP:0002419)2.25614834
50Abnormality of midbrain morphology (HP:0002418)2.25614834
51Nephronophthisis (HP:0000090)2.23745643
52Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.21128122
53True hermaphroditism (HP:0010459)2.20056956
54Lethargy (HP:0001254)2.19113405
55Optic disc pallor (HP:0000543)2.18954607
56Respiratory failure (HP:0002878)2.18334029
57Exercise-induced muscle cramps (HP:0003710)2.13425033
58Abnormal number of erythroid precursors (HP:0012131)2.13324747
59Increased serum lactate (HP:0002151)2.13047117
60Hyperglycinuria (HP:0003108)2.11681134
61Abnormal protein glycosylation (HP:0012346)2.10040108
62Abnormal glycosylation (HP:0012345)2.10040108
63Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.10040108
64Abnormal protein N-linked glycosylation (HP:0012347)2.10040108
65Type II lissencephaly (HP:0007260)2.09808666
66Abnormal lung lobation (HP:0002101)2.03351447
67Type 2 muscle fiber atrophy (HP:0003554)2.02914143
68Abnormality of renal resorption (HP:0011038)2.02657184
69Inability to walk (HP:0002540)2.01324555
70Testicular atrophy (HP:0000029)2.00309514
71Abnormality of aspartate family amino acid metabolism (HP:0010899)1.99319696
72Abnormality of alanine metabolism (HP:0010916)1.98294921
73Hyperalaninemia (HP:0003348)1.98294921
74Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.98294921
75Hyperphosphaturia (HP:0003109)1.97271893
76Aplasia/hypoplasia of the uterus (HP:0008684)1.95852067
77Exercise intolerance (HP:0003546)1.94034444
78Decreased activity of mitochondrial respiratory chain (HP:0008972)1.93134666
79Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.93134666
80Supernumerary spleens (HP:0009799)1.92742406
81Abnormality of cells of the erythroid lineage (HP:0012130)1.92364379
82Glycosuria (HP:0003076)1.91624257
83Abnormality of urine glucose concentration (HP:0011016)1.91624257
84Oral leukoplakia (HP:0002745)1.89109119
85Prostate neoplasm (HP:0100787)1.88648206
86Abnormality of the renal medulla (HP:0100957)1.88238998
87Neonatal respiratory distress (HP:0002643)1.87538103
88Abnormality of the prostate (HP:0008775)1.86662917
89Polyphagia (HP:0002591)1.86350416
90Rimmed vacuoles (HP:0003805)1.85596547
91Chronic hepatic failure (HP:0100626)1.85209644
92Hyperlipoproteinemia (HP:0010980)1.84691875
93Colon cancer (HP:0003003)1.84643520
94Prolonged partial thromboplastin time (HP:0003645)1.83057886
95Severe muscular hypotonia (HP:0006829)1.82939425
96Pancreatic islet-cell hyperplasia (HP:0004510)1.82355044
97Respiratory difficulties (HP:0002880)1.82172469
98Abnormality of the pons (HP:0007361)1.81551263
99Abnormality of macular pigmentation (HP:0008002)1.81286043
100Aplastic anemia (HP:0001915)1.80584681

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.54950751
2ZAK3.66724905
3TXK3.21929668
4NUAK12.70080526
5MKNK12.63978433
6TAOK32.58125145
7SRPK12.50757203
8BMPR1B2.35954245
9GRK12.31525244
10WNK32.24689981
11MAP4K22.15504781
12BCKDK2.08784254
13BUB12.02618266
14TNIK1.99048159
15VRK21.94709219
16TSSK61.78285127
17PINK11.73826116
18MST41.69476887
19VRK11.60423447
20FRK1.59847122
21ADRBK21.59779583
22EIF2AK31.47950239
23PASK1.45021945
24NEK11.44809796
25PLK41.42503870
26PLK31.37738713
27CDK191.34280473
28FLT31.33043192
29BMPR21.31122584
30FGFR21.31035087
31MAPKAPK51.24730879
32TEC1.16835178
33EPHA31.09107858
34AKT31.08301925
35PBK1.07494603
36TGFBR11.00350817
37KDR1.00289253
38PNCK0.99435769
39TNK20.98999329
40PHKG20.98436249
41PHKG10.98436249
42INSRR0.96530574
43STK240.91101045
44ERBB30.85686632
45NME20.85585717
46ALK0.83663443
47BCR0.83607217
48MARK10.80644196
49WEE10.76926378
50DYRK20.75610824
51OXSR10.72039825
52SIK30.68567397
53TAF10.67694816
54PIM10.67627402
55CAMK2A0.65526791
56PRKCG0.64398207
57PRKCE0.64350694
58FGFR10.63002501
59MAPK70.62884090
60TRIM280.62396943
61TLK10.61351795
62MAPK130.59913397
63MKNK20.57844452
64CSNK1G10.57784163
65PRKG20.56333715
66NTRK30.55985745
67PDK20.53617731
68MAP4K10.53256397
69MAP3K120.53189957
70IGF1R0.52273885
71EIF2AK20.52107930
72TTK0.51741805
73CSNK2A10.51171032
74BTK0.51113343
75WNK40.50959281
76ADRBK10.50944508
77PLK10.50132477
78CSNK1G20.49827573
79DYRK30.48340306
80CSNK1A10.48058388
81EPHA40.47394966
82MAPK150.47258432
83LATS10.47096805
84RPS6KA50.44529105
85PAK30.44351197
86MINK10.43698230
87MAP2K60.42924973
88PRKCQ0.41211088
89PRKACA0.41157655
90CSNK2A20.41123178
91LYN0.40290417
92PRKG10.40261924
93CAMK2D0.40168016
94ITK0.40111090
95MATK0.39463738
96MAP3K40.37796392
97AURKB0.37298756
98ATM0.37110519
99ATR0.36978138
100NLK0.36347625

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.07142800
2Oxidative phosphorylation_Homo sapiens_hsa001903.64426348
3Parkinsons disease_Homo sapiens_hsa050123.37142989
4Proteasome_Homo sapiens_hsa030503.30164221
5Protein export_Homo sapiens_hsa030602.90565932
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.23305170
7Huntingtons disease_Homo sapiens_hsa050162.09083765
8Propanoate metabolism_Homo sapiens_hsa006402.02280102
9Selenocompound metabolism_Homo sapiens_hsa004502.01394946
10RNA polymerase_Homo sapiens_hsa030201.93041879
11Alzheimers disease_Homo sapiens_hsa050101.87687968
12Basal transcription factors_Homo sapiens_hsa030221.86015981
13Spliceosome_Homo sapiens_hsa030401.82935187
14Linoleic acid metabolism_Homo sapiens_hsa005911.79311827
15Homologous recombination_Homo sapiens_hsa034401.79302011
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.71852426
17Phototransduction_Homo sapiens_hsa047441.71329550
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.71087469
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.70996507
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.65941369
21Nitrogen metabolism_Homo sapiens_hsa009101.62337587
22One carbon pool by folate_Homo sapiens_hsa006701.61529325
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.60909923
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.56872418
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.54051619
26Mismatch repair_Homo sapiens_hsa034301.51755453
27RNA degradation_Homo sapiens_hsa030181.47967621
28Cardiac muscle contraction_Homo sapiens_hsa042601.45904941
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.39377766
30Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.39247511
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33191322
32Base excision repair_Homo sapiens_hsa034101.25836254
33Nicotine addiction_Homo sapiens_hsa050331.24253185
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.24057884
35Fanconi anemia pathway_Homo sapiens_hsa034601.20336390
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19896238
37Cyanoamino acid metabolism_Homo sapiens_hsa004601.17698220
38Ether lipid metabolism_Homo sapiens_hsa005651.15386386
39Pentose and glucuronate interconversions_Homo sapiens_hsa000401.13589685
40Peroxisome_Homo sapiens_hsa041461.07041841
41Butanoate metabolism_Homo sapiens_hsa006501.05966223
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.04617024
43Non-homologous end-joining_Homo sapiens_hsa034501.00338038
44Arachidonic acid metabolism_Homo sapiens_hsa005900.99540743
45Cysteine and methionine metabolism_Homo sapiens_hsa002700.99092409
46Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.98520396
47Taste transduction_Homo sapiens_hsa047420.98147763
48Glycerolipid metabolism_Homo sapiens_hsa005610.97855134
49RNA transport_Homo sapiens_hsa030130.94972230
50Tryptophan metabolism_Homo sapiens_hsa003800.94538599
51Purine metabolism_Homo sapiens_hsa002300.93955854
52Vitamin digestion and absorption_Homo sapiens_hsa049770.93823894
53Serotonergic synapse_Homo sapiens_hsa047260.90275317
54Fatty acid elongation_Homo sapiens_hsa000620.87714988
55Chemical carcinogenesis_Homo sapiens_hsa052040.87473874
56Pyrimidine metabolism_Homo sapiens_hsa002400.87354540
57Nucleotide excision repair_Homo sapiens_hsa034200.81904955
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79053719
59Fatty acid biosynthesis_Homo sapiens_hsa000610.77525213
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77272906
61Metabolic pathways_Homo sapiens_hsa011000.75747369
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74987422
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.74250960
64Glutathione metabolism_Homo sapiens_hsa004800.73180942
65GABAergic synapse_Homo sapiens_hsa047270.66399072
66N-Glycan biosynthesis_Homo sapiens_hsa005100.66320833
67Ovarian steroidogenesis_Homo sapiens_hsa049130.61280029
68Retinol metabolism_Homo sapiens_hsa008300.61279988
69Pyruvate metabolism_Homo sapiens_hsa006200.60166653
70ABC transporters_Homo sapiens_hsa020100.59831650
71Fatty acid degradation_Homo sapiens_hsa000710.56474228
72Fat digestion and absorption_Homo sapiens_hsa049750.54575217
73mRNA surveillance pathway_Homo sapiens_hsa030150.54552841
74Long-term depression_Homo sapiens_hsa047300.54222103
75Caffeine metabolism_Homo sapiens_hsa002320.52410800
76DNA replication_Homo sapiens_hsa030300.51584579
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51155226
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51117383
79Steroid biosynthesis_Homo sapiens_hsa001000.48341360
80Glutamatergic synapse_Homo sapiens_hsa047240.47971876
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.45058254
82Asthma_Homo sapiens_hsa053100.44697186
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.43696283
84Morphine addiction_Homo sapiens_hsa050320.41805451
85Olfactory transduction_Homo sapiens_hsa047400.39104054
86Fatty acid metabolism_Homo sapiens_hsa012120.39072291
87Circadian entrainment_Homo sapiens_hsa047130.38041798
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37403802
89Regulation of autophagy_Homo sapiens_hsa041400.36824324
90Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.34424467
91beta-Alanine metabolism_Homo sapiens_hsa004100.33564755
92Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33516368
93Fructose and mannose metabolism_Homo sapiens_hsa000510.33186444
94Type I diabetes mellitus_Homo sapiens_hsa049400.31850118
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31735687
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.31735414
97Primary immunodeficiency_Homo sapiens_hsa053400.30800080
98Cocaine addiction_Homo sapiens_hsa050300.28178501
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.27476305
100Mineral absorption_Homo sapiens_hsa049780.26781710

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