HNRNPA1P61

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)7.49423036
2DNA deamination (GO:0045006)6.59421298
3regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.82499372
4ATP synthesis coupled proton transport (GO:0015986)4.67780411
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.67780411
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.57706672
7cytidine deamination (GO:0009972)4.54941887
8cytidine metabolic process (GO:0046087)4.54941887
9cytidine catabolic process (GO:0006216)4.54941887
10ribosomal small subunit assembly (GO:0000028)4.39286402
11chaperone-mediated protein transport (GO:0072321)4.22373764
12protein deneddylation (GO:0000338)4.10895538
13platelet dense granule organization (GO:0060155)4.03019394
14pyrimidine ribonucleoside catabolic process (GO:0046133)3.80588659
15water-soluble vitamin biosynthetic process (GO:0042364)3.78572901
16mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.56528214
17protein complex biogenesis (GO:0070271)3.54722130
18positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.50343475
19mitochondrial respiratory chain complex I assembly (GO:0032981)3.49822274
20NADH dehydrogenase complex assembly (GO:0010257)3.49822274
21mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.49822274
22base-excision repair, AP site formation (GO:0006285)3.46598658
23cullin deneddylation (GO:0010388)3.40773283
24GPI anchor metabolic process (GO:0006505)3.31841797
25sequestering of actin monomers (GO:0042989)3.24404273
26nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.22924226
27mitochondrial respiratory chain complex assembly (GO:0033108)3.17261202
28protein neddylation (GO:0045116)3.07707124
29exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.07589275
30GPI anchor biosynthetic process (GO:0006506)3.04527133
31electron transport chain (GO:0022900)2.99485575
32respiratory chain complex IV assembly (GO:0008535)2.96479491
33cellular response to interleukin-15 (GO:0071350)2.95678390
34respiratory electron transport chain (GO:0022904)2.95160041
35pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.94426737
36tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.94177807
37RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.94177807
38regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.94067904
39cytochrome complex assembly (GO:0017004)2.93241582
40resolution of meiotic recombination intermediates (GO:0000712)2.93158666
41proteasome assembly (GO:0043248)2.92422793
42establishment of protein localization to mitochondrial membrane (GO:0090151)2.90389514
43GTP biosynthetic process (GO:0006183)2.89465641
44regulation of regulatory T cell differentiation (GO:0045589)2.83919790
45adenosine metabolic process (GO:0046085)2.82651793
46regulation of isotype switching to IgG isotypes (GO:0048302)2.79322205
47purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.75771899
48purine nucleoside triphosphate biosynthetic process (GO:0009145)2.73170491
49behavioral response to nicotine (GO:0035095)2.71911793
50ATP biosynthetic process (GO:0006754)2.71447559
51deoxyribonucleotide catabolic process (GO:0009264)2.70453536
52preassembly of GPI anchor in ER membrane (GO:0016254)2.70268103
53SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.69886522
54regulation of mitotic spindle checkpoint (GO:1903504)2.68964625
55regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.68964625
56deoxyribose phosphate catabolic process (GO:0046386)2.67478471
57cotranslational protein targeting to membrane (GO:0006613)2.66379283
58RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.65126592
59purine deoxyribonucleotide catabolic process (GO:0009155)2.65104139
60negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.62185456
61maturation of SSU-rRNA (GO:0030490)2.61445352
62protein targeting to ER (GO:0045047)2.61047411
63negative regulation by host of viral transcription (GO:0043922)2.60488438
64viral transcription (GO:0019083)2.59027832
65regulation of memory T cell differentiation (GO:0043380)2.58777827
66regulation of immunoglobulin secretion (GO:0051023)2.56674175
67aldehyde catabolic process (GO:0046185)2.55698990
68regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.54926910
69translational termination (GO:0006415)2.54457457
70translational elongation (GO:0006414)2.54123752
71establishment of protein localization to endoplasmic reticulum (GO:0072599)2.53926028
72regulation of cellular amino acid metabolic process (GO:0006521)2.53537316
73positive regulation of activated T cell proliferation (GO:0042104)2.51495713
74regulation of T cell receptor signaling pathway (GO:0050856)2.51258618
75UTP metabolic process (GO:0046051)2.51042235
76positive regulation of interleukin-17 production (GO:0032740)2.50111985
77mannosylation (GO:0097502)2.47393817
78negative regulation of mast cell activation (GO:0033004)2.45729709
79ribonucleoside triphosphate biosynthetic process (GO:0009201)2.43876136
80DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.43792114
81positive regulation of T cell mediated cytotoxicity (GO:0001916)2.43023397
82positive regulation of prostaglandin secretion (GO:0032308)2.42770065
83protein localization to endoplasmic reticulum (GO:0070972)2.42499187
84urate metabolic process (GO:0046415)2.41024397
85pseudouridine synthesis (GO:0001522)2.40694939
86translation (GO:0006412)2.40567520
87pyrimidine ribonucleoside metabolic process (GO:0046131)2.39568517
88pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.39251249
89signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.39216346
90signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.39216346
91signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.39216346
92UTP biosynthetic process (GO:0006228)2.37208474
93positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.36208130
94somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.36127732
95somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.36127732
96isotype switching (GO:0045190)2.36127732
97regulation of triglyceride catabolic process (GO:0010896)2.36076757
98intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.34453673
99signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.34453673
100chromatin remodeling at centromere (GO:0031055)2.33700050

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.14957233
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.84634672
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.70919162
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.15359650
5ZNF274_21170338_ChIP-Seq_K562_Hela2.85805204
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.80810487
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.77317048
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.75760254
9VDR_22108803_ChIP-Seq_LS180_Human2.70155950
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.61011156
11VDR_23849224_ChIP-Seq_CD4+_Human2.55685251
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.54047956
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.44523276
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.39516503
15ELK1_19687146_ChIP-ChIP_HELA_Human2.39220632
16PCGF2_27294783_Chip-Seq_ESCs_Mouse2.22186319
17EWS_26573619_Chip-Seq_HEK293_Human2.20976466
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.14335433
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.14183598
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.07771897
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.06885914
22FOXP3_21729870_ChIP-Seq_TREG_Human2.00857211
23TAF15_26573619_Chip-Seq_HEK293_Human2.00744217
24MYC_18940864_ChIP-ChIP_HL60_Human1.94547851
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.87726640
26SRF_21415370_ChIP-Seq_HL-1_Mouse1.86895906
27IGF1R_20145208_ChIP-Seq_DFB_Human1.84228697
28PCGF2_27294783_Chip-Seq_NPCs_Mouse1.71270852
29CREB1_15753290_ChIP-ChIP_HEK293T_Human1.69175960
30FUS_26573619_Chip-Seq_HEK293_Human1.68239732
31IRF1_19129219_ChIP-ChIP_H3396_Human1.67891806
32MYC_18555785_ChIP-Seq_MESCs_Mouse1.67165487
33TP53_22573176_ChIP-Seq_HFKS_Human1.64612882
34IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.61086907
35PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.60278443
36E2F4_17652178_ChIP-ChIP_JURKAT_Human1.57205939
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.52790897
38P300_19829295_ChIP-Seq_ESCs_Human1.49490851
39EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.48741426
40IRF8_22096565_ChIP-ChIP_GC-B_Human1.46496536
41SOX2_19829295_ChIP-Seq_ESCs_Human1.44895327
42NANOG_19829295_ChIP-Seq_ESCs_Human1.44895327
43POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.42780650
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42247238
45EZH2_22144423_ChIP-Seq_EOC_Human1.40989400
46EGR1_23403033_ChIP-Seq_LIVER_Mouse1.38217321
47FOXA1_25329375_ChIP-Seq_VCAP_Human1.36742273
48FOXA1_27270436_Chip-Seq_PROSTATE_Human1.36742273
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.36328955
50AR_20517297_ChIP-Seq_VCAP_Human1.35481395
51PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35280218
52STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.31710964
53POU3F2_20337985_ChIP-ChIP_501MEL_Human1.31319789
54CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.30175926
55GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.29421721
56MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27947637
57PADI4_21655091_ChIP-ChIP_MCF-7_Human1.26878398
58CTBP1_25329375_ChIP-Seq_LNCAP_Human1.26448310
59PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.24917423
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.23168638
61SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21621922
62AUTS2_25519132_ChIP-Seq_293T-REX_Human1.20878373
63FOXA1_21572438_ChIP-Seq_LNCaP_Human1.18879303
64FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.18663834
65NFE2_27457419_Chip-Seq_LIVER_Mouse1.18541388
66GATA3_26560356_Chip-Seq_TH2_Human1.18281396
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17193009
68CBP_20019798_ChIP-Seq_JUKART_Human1.17193009
69NANOG_20526341_ChIP-Seq_ESCs_Human1.17042679
70FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.16625664
71MYC_18358816_ChIP-ChIP_MESCs_Mouse1.16240492
72POU5F1_16153702_ChIP-ChIP_HESCs_Human1.15739437
73MYB_26560356_Chip-Seq_TH2_Human1.14183871
74ER_23166858_ChIP-Seq_MCF-7_Human1.13902710
75EZH2_27294783_Chip-Seq_NPCs_Mouse1.12592660
76RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10912385
77CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10054125
78CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.09275771
79ERG_20517297_ChIP-Seq_VCAP_Human1.06966544
80ZFP57_27257070_Chip-Seq_ESCs_Mouse1.05257681
81NCOR_22424771_ChIP-Seq_293T_Human1.04812728
82SOX2_16153702_ChIP-ChIP_HESCs_Human1.04507108
83CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.04232315
84TTF2_22483619_ChIP-Seq_HELA_Human1.02637563
85ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01635664
86FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.01233738
87FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.98659216
88MYC_19030024_ChIP-ChIP_MESCs_Mouse0.98412349
89GATA3_21878914_ChIP-Seq_MCF-7_Human0.98239635
90ELK1_22589737_ChIP-Seq_MCF10A_Human0.96071864
91CRX_20693478_ChIP-Seq_RETINA_Mouse0.94973160
92CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.94748657
93NANOG_16153702_ChIP-ChIP_HESCs_Human0.94666373
94TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94089969
95HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.93874210
96E2F1_18555785_ChIP-Seq_MESCs_Mouse0.93794555
97GABP_19822575_ChIP-Seq_HepG2_Human0.93021335
98YY1_21170310_ChIP-Seq_MESCs_Mouse0.90981124
99SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.89715465
100DCP1A_22483619_ChIP-Seq_HELA_Human0.89675751

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.32127150
2MP0006292_abnormal_olfactory_placode2.86359341
3MP0001835_abnormal_antigen_presentation2.76729349
4MP0006072_abnormal_retinal_apoptosis2.76187493
5MP0009785_altered_susceptibility_to2.57363605
6MP0008872_abnormal_physiological_respon2.49960940
7MP0008875_abnormal_xenobiotic_pharmacok2.40965367
8MP0005084_abnormal_gallbladder_morpholo2.35682524
9MP0002102_abnormal_ear_morphology2.26940852
10MP0003195_calcinosis2.14148753
11MP0008877_abnormal_DNA_methylation2.12725203
12MP0009333_abnormal_splenocyte_physiolog2.11191578
13MP0004147_increased_porphyrin_level2.07794343
14MP0005645_abnormal_hypothalamus_physiol1.85787407
15MP0003283_abnormal_digestive_organ1.74180169
16MP0002736_abnormal_nociception_after1.71133282
17MP0002277_abnormal_respiratory_mucosa1.69875805
18MP0002148_abnormal_hypersensitivity_rea1.67862825
19MP0005000_abnormal_immune_tolerance1.66438206
20MP0005551_abnormal_eye_electrophysiolog1.65848253
21MP0005085_abnormal_gallbladder_physiolo1.62210777
22MP0002166_altered_tumor_susceptibility1.61949054
23MP0001800_abnormal_humoral_immune1.59854721
24MP0009379_abnormal_foot_pigmentation1.54545296
25MP0001529_abnormal_vocalization1.45901977
26MP0002163_abnormal_gland_morphology1.45456905
27MP0001968_abnormal_touch/_nociception1.45103529
28MP0003806_abnormal_nucleotide_metabolis1.44711602
29MP0002723_abnormal_immune_serum1.43549004
30MP0003786_premature_aging1.39561005
31MP0005646_abnormal_pituitary_gland1.38618246
32MP0003878_abnormal_ear_physiology1.37970480
33MP0005377_hearing/vestibular/ear_phenot1.37970480
34MP0002138_abnormal_hepatobiliary_system1.37860629
35MP0001919_abnormal_reproductive_system1.35340406
36MP0003763_abnormal_thymus_physiology1.35091130
37MP0002006_tumorigenesis1.34211305
38MP0003011_delayed_dark_adaptation1.33290414
39MP0005253_abnormal_eye_physiology1.29207283
40MP0005410_abnormal_fertilization1.26984769
41MP0002234_abnormal_pharynx_morphology1.25057877
42MP0001873_stomach_inflammation1.24003349
43MP0005379_endocrine/exocrine_gland_phen1.22555352
44MP0002876_abnormal_thyroid_physiology1.21941579
45MP0002420_abnormal_adaptive_immunity1.20026834
46MP0003693_abnormal_embryo_hatching1.19334056
47MP0001819_abnormal_immune_cell1.18732470
48MP0004043_abnormal_pH_regulation1.18649721
49MP0005025_abnormal_response_to1.18252329
50MP0001986_abnormal_taste_sensitivity1.16523058
51MP0002405_respiratory_system_inflammati1.15535709
52MP0005389_reproductive_system_phenotype1.15068232
53MP0002653_abnormal_ependyma_morphology1.14973854
54MP0001905_abnormal_dopamine_level1.13304371
55MP0009697_abnormal_copulation1.09546729
56MP0010155_abnormal_intestine_physiology1.09367896
57MP0002452_abnormal_antigen_presenting1.08726654
58MP0005387_immune_system_phenotype1.04891882
59MP0001790_abnormal_immune_system1.04891882
60MP0001293_anophthalmia1.04534486
61MP0003567_abnormal_fetal_cardiomyocyte1.04363214
62MP0000049_abnormal_middle_ear1.03977570
63MP0008058_abnormal_DNA_repair1.01873260
64MP0003787_abnormal_imprinting1.00154600
65MP0003866_abnormal_defecation0.99704561
66MP0001845_abnormal_inflammatory_respons0.99121312
67MP0000372_irregular_coat_pigmentation0.98916169
68MP0000716_abnormal_immune_system0.97939988
69MP0008995_early_reproductive_senescence0.97343852
70MP0003252_abnormal_bile_duct0.95679513
71MP0009764_decreased_sensitivity_to0.93396412
72MP0005332_abnormal_amino_acid0.92378814
73MP0001764_abnormal_homeostasis0.90105104
74MP0000689_abnormal_spleen_morphology0.89798407
75MP0001501_abnormal_sleep_pattern0.89336193
76MP0002722_abnormal_immune_system0.87453170
77MP0003186_abnormal_redox_activity0.86771804
78MP0002398_abnormal_bone_marrow0.86234879
79MP0006036_abnormal_mitochondrial_physio0.85975947
80MP0009643_abnormal_urine_homeostasis0.85568473
81MP0005636_abnormal_mineral_homeostasis0.84688818
82MP0000703_abnormal_thymus_morphology0.83788071
83MP0002009_preneoplasia0.83425782
84MP0005367_renal/urinary_system_phenotyp0.83135419
85MP0000516_abnormal_urinary_system0.83135419
86MP0009745_abnormal_behavioral_response0.83020113
87MP0001485_abnormal_pinna_reflex0.82792992
88MP0006276_abnormal_autonomic_nervous0.82765488
89MP0001119_abnormal_female_reproductive0.80549820
90MP0002837_dystrophic_cardiac_calcinosis0.80391617
91MP0004142_abnormal_muscle_tone0.80245424
92MP0005075_abnormal_melanosome_morpholog0.80061705
93MP0001929_abnormal_gametogenesis0.78186774
94MP0001188_hyperpigmentation0.77267083
95MP0000465_gastrointestinal_hemorrhage0.76861871
96MP0000631_abnormal_neuroendocrine_gland0.76692349
97MP0002429_abnormal_blood_cell0.76087843
98MP0008007_abnormal_cellular_replicative0.75329763
99MP0003718_maternal_effect0.74062949
100MP0000685_abnormal_immune_system0.72114954

Predicted human phenotypes

RankGene SetZ-score
13-Methylglutaconic aciduria (HP:0003535)3.45623231
2Acute necrotizing encephalopathy (HP:0006965)3.45577030
3Hypoproteinemia (HP:0003075)3.44672748
4Mitochondrial inheritance (HP:0001427)3.30995860
5Stomatitis (HP:0010280)3.22554896
6Progressive macrocephaly (HP:0004481)3.14124109
7Pancreatic cysts (HP:0001737)3.10150445
8Meckel diverticulum (HP:0002245)3.04250277
9Hepatocellular necrosis (HP:0001404)3.01013783
10Abnormal mitochondria in muscle tissue (HP:0008316)3.00586003
11Methylmalonic acidemia (HP:0002912)2.98730334
12Abnormality of the ileum (HP:0001549)2.97276111
13Acute encephalopathy (HP:0006846)2.95533956
14IgG deficiency (HP:0004315)2.91039150
15Increased CSF lactate (HP:0002490)2.88960202
16Abnormality of the pons (HP:0007361)2.87643542
17Absent rod-and cone-mediated responses on ERG (HP:0007688)2.79914045
18Aplasia/Hypoplasia of the uvula (HP:0010293)2.77432663
19Congenital, generalized hypertrichosis (HP:0004540)2.73292515
20Type I transferrin isoform profile (HP:0003642)2.72946374
21Pancreatic fibrosis (HP:0100732)2.72802528
22True hermaphroditism (HP:0010459)2.71380050
23Hepatic necrosis (HP:0002605)2.65284710
24Hypoplasia of the pons (HP:0012110)2.65096136
25Cerebral edema (HP:0002181)2.58253695
26Thyroiditis (HP:0100646)2.49701808
27Abolished electroretinogram (ERG) (HP:0000550)2.48679096
28Severe combined immunodeficiency (HP:0004430)2.44351533
29Congenital stationary night blindness (HP:0007642)2.43886292
30Renal cortical cysts (HP:0000803)2.43667425
31Abnormality of B cell number (HP:0010975)2.40481373
32Clubbing of toes (HP:0100760)2.39227781
33Aplasia/hypoplasia of the uterus (HP:0008684)2.39076683
34Abnormal protein glycosylation (HP:0012346)2.38544918
35Abnormal glycosylation (HP:0012345)2.38544918
36Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.38544918
37Abnormal protein N-linked glycosylation (HP:0012347)2.38544918
38Nephronophthisis (HP:0000090)2.37975703
39Increased hepatocellular lipid droplets (HP:0006565)2.32590565
40Attenuation of retinal blood vessels (HP:0007843)2.32586069
41Abnormality of the renal cortex (HP:0011035)2.32341943
42Abnormality of the preputium (HP:0100587)2.31357785
43Optic disc pallor (HP:0000543)2.30487040
44Hypoplasia of the uterus (HP:0000013)2.30074358
45B lymphocytopenia (HP:0010976)2.27267107
46Abnormal rod and cone electroretinograms (HP:0008323)2.23291404
47Methylmalonic aciduria (HP:0012120)2.19575514
48Elevated erythrocyte sedimentation rate (HP:0003565)2.19454094
49Increased serum lactate (HP:0002151)2.17974918
50Lipid accumulation in hepatocytes (HP:0006561)2.14612226
51T lymphocytopenia (HP:0005403)2.14340766
52Reduced antithrombin III activity (HP:0001976)2.13674688
53Abnormality of alanine metabolism (HP:0010916)2.13025917
54Hyperalaninemia (HP:0003348)2.13025917
55Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.13025917
56Pendular nystagmus (HP:0012043)2.11781707
57Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.11642503
58Abnormality of the prostate (HP:0008775)2.11151894
59Abnormality of T cell number (HP:0011839)2.05706941
60Aplastic anemia (HP:0001915)2.03999415
61Exertional dyspnea (HP:0002875)2.03729048
62Renal Fanconi syndrome (HP:0001994)2.03583853
63Abnormality of chromosome stability (HP:0003220)2.03547443
64Type 2 muscle fiber atrophy (HP:0003554)2.03436022
65Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.02457859
66Aplasia/Hypoplasia of the spleen (HP:0010451)2.01016038
67Molar tooth sign on MRI (HP:0002419)2.00988344
68Abnormality of midbrain morphology (HP:0002418)2.00988344
69Lactic acidosis (HP:0003128)1.97522357
70Combined immunodeficiency (HP:0005387)1.96980312
71Asplenia (HP:0001746)1.96976694
72Abnormality of the vitamin B12 metabolism (HP:0004341)1.96443438
73Absent thumb (HP:0009777)1.96048098
74Constricted visual fields (HP:0001133)1.95434638
75Duodenal stenosis (HP:0100867)1.94804807
76Small intestinal stenosis (HP:0012848)1.94804807
77Colon cancer (HP:0003003)1.94777021
78Abnormality of the renal medulla (HP:0100957)1.92869288
79Abnormality of aspartate family amino acid metabolism (HP:0010899)1.92585967
80Hypoalbuminemia (HP:0003073)1.91075504
81Abnormal albumin level (HP:0012116)1.91075504
82Decreased activity of mitochondrial respiratory chain (HP:0008972)1.87144233
83Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.87144233
84Abnormality of the renal collecting system (HP:0004742)1.86337391
85Hypomagnesemia (HP:0002917)1.86155836
86Pancreatic islet-cell hyperplasia (HP:0004510)1.85405976
87Short tibia (HP:0005736)1.84937448
88Abnormality of vitamin B metabolism (HP:0004340)1.84252464
89Lethargy (HP:0001254)1.84228871
90Triphalangeal thumb (HP:0001199)1.83692909
91Thyroid-stimulating hormone excess (HP:0002925)1.83559629
92Neonatal respiratory distress (HP:0002643)1.80873036
93Poor head control (HP:0002421)1.74973239
94Abnormality of the duodenum (HP:0002246)1.74850122
95Increased intramyocellular lipid droplets (HP:0012240)1.74554654
96Increased serum pyruvate (HP:0003542)1.74214662
97Exercise intolerance (HP:0003546)1.73465626
98Leukodystrophy (HP:0002415)1.72629277
99Keratoconus (HP:0000563)1.72305413
100Increased corneal curvature (HP:0100692)1.72305413

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K24.32535273
2TLK13.45400814
3ZAK3.37927577
4MST43.35417660
5TXK3.08782236
6BCKDK3.03202874
7NUAK12.80534540
8KDR2.47267750
9VRK22.46869447
10TAOK32.28577848
11FRK2.13198076
12CDK192.11508757
13ADRBK21.99921768
14VRK11.97627467
15INSRR1.97184133
16MKNK11.73933431
17GRK11.70642890
18GRK61.67838941
19LMTK21.61811312
20MAP4K11.58579214
21PINK11.51391565
22SRPK11.50558510
23IKBKE1.39924825
24ERBB31.37343220
25FLT31.33777262
26EIF2AK31.32181830
27TESK21.27036599
28PASK1.23754668
29WNK31.21137715
30KIT1.20968971
31IKBKB1.17664278
32BMPR21.13144130
33TIE11.10468999
34BMPR1B1.07605577
35ACVR1B1.02851411
36EIF2AK21.02827186
37DYRK21.02465876
38TEC0.98300752
39PLK30.95919482
40MAP3K140.95081595
41BUB10.94831483
42PKN10.90456236
43ITK0.86928713
44PIK3CG0.85099012
45GRK70.83407109
46MATK0.80790003
47MUSK0.79450652
48WNK40.78941170
49RPS6KA50.73755348
50CSNK1G30.70915830
51OXSR10.68699681
52TNK20.67566252
53PRKCQ0.67390632
54BTK0.67079963
55JAK30.66870615
56PBK0.66710221
57LYN0.65884905
58NEK10.65879019
59TAF10.65616478
60TBK10.64040900
61LCK0.63806202
62TSSK60.61179146
63STK160.58698685
64SYK0.57992586
65CSF1R0.57588054
66LIMK10.56987947
67RPS6KA40.53214223
68CSNK1G10.52813075
69TGFBR10.51799658
70ADRBK10.50801312
71AURKB0.50493112
72CSNK1G20.49816173
73MAPK130.48735494
74FES0.48682636
75GRK50.46880952
76CDC70.46438938
77EPHA40.46077589
78TRIM280.44299165
79PIM10.43155381
80PRKCE0.42805866
81NME10.42665379
82CSNK1A1L0.42046746
83IGF1R0.41554934
84DAPK30.41015951
85PLK10.40560359
86CHEK20.39241354
87PRKG20.38261777
88MAP3K120.36432079
89MKNK20.36348470
90PLK40.35521840
91CSNK2A10.35448041
92OBSCN0.35037937
93NEK20.33491740
94MAP2K60.33154682
95CSNK1A10.32752971
96ATR0.32718263
97AURKA0.32616109
98WEE10.32597242
99ERBB20.31730667
100PRKCA0.31275292

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.35724009
2Asthma_Homo sapiens_hsa053103.11739695
3Protein export_Homo sapiens_hsa030602.99781556
4Oxidative phosphorylation_Homo sapiens_hsa001902.97617142
5Allograft rejection_Homo sapiens_hsa053302.74968381
6Graft-versus-host disease_Homo sapiens_hsa053322.73727557
7Ribosome_Homo sapiens_hsa030102.73262364
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.57949553
9Autoimmune thyroid disease_Homo sapiens_hsa053202.51340084
10Parkinsons disease_Homo sapiens_hsa050122.41567218
11Primary immunodeficiency_Homo sapiens_hsa053402.25483593
12RNA polymerase_Homo sapiens_hsa030202.21012134
13Sulfur metabolism_Homo sapiens_hsa009202.17998530
14Type I diabetes mellitus_Homo sapiens_hsa049402.09709438
15Homologous recombination_Homo sapiens_hsa034401.87490950
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.84730324
17Propanoate metabolism_Homo sapiens_hsa006401.76002015
18Antigen processing and presentation_Homo sapiens_hsa046121.71347510
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.58736746
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.54664556
21Fanconi anemia pathway_Homo sapiens_hsa034601.54518131
22Nitrogen metabolism_Homo sapiens_hsa009101.52662023
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.49201689
24One carbon pool by folate_Homo sapiens_hsa006701.46304123
25Alzheimers disease_Homo sapiens_hsa050101.45786320
26Huntingtons disease_Homo sapiens_hsa050161.44728286
27RNA degradation_Homo sapiens_hsa030181.44715944
28Systemic lupus erythematosus_Homo sapiens_hsa053221.39882668
29Base excision repair_Homo sapiens_hsa034101.33922305
30Rheumatoid arthritis_Homo sapiens_hsa053231.32775982
31Phototransduction_Homo sapiens_hsa047441.31742461
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.25964694
33Pyrimidine metabolism_Homo sapiens_hsa002401.24478861
34Spliceosome_Homo sapiens_hsa030401.23882314
35Mismatch repair_Homo sapiens_hsa034301.21893237
36Butanoate metabolism_Homo sapiens_hsa006501.21461079
37Basal transcription factors_Homo sapiens_hsa030221.20044515
38Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.18175776
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17930247
40Hematopoietic cell lineage_Homo sapiens_hsa046401.15460133
41Linoleic acid metabolism_Homo sapiens_hsa005911.15407591
42DNA replication_Homo sapiens_hsa030301.10065682
43Peroxisome_Homo sapiens_hsa041461.08295070
44Caffeine metabolism_Homo sapiens_hsa002321.04912442
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.04038577
46Purine metabolism_Homo sapiens_hsa002301.03949898
47Tryptophan metabolism_Homo sapiens_hsa003801.03672300
48Cardiac muscle contraction_Homo sapiens_hsa042601.01084243
49Retinol metabolism_Homo sapiens_hsa008301.00473663
50RNA transport_Homo sapiens_hsa030130.99086179
51Nucleotide excision repair_Homo sapiens_hsa034200.98295828
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.97380314
53Cysteine and methionine metabolism_Homo sapiens_hsa002700.91077839
54Chemical carcinogenesis_Homo sapiens_hsa052040.89891060
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86913470
56Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86207466
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.83233574
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81830319
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77234248
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.76224407
61Viral myocarditis_Homo sapiens_hsa054160.76140732
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75600608
63Selenocompound metabolism_Homo sapiens_hsa004500.75430472
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.71973032
65Non-homologous end-joining_Homo sapiens_hsa034500.71224544
66Drug metabolism - other enzymes_Homo sapiens_hsa009830.70306057
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67628248
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.65309460
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.64836776
70Arachidonic acid metabolism_Homo sapiens_hsa005900.63730212
71Metabolic pathways_Homo sapiens_hsa011000.57231989
72Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57180229
73Staphylococcus aureus infection_Homo sapiens_hsa051500.54395522
74beta-Alanine metabolism_Homo sapiens_hsa004100.51109094
75Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.49135731
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.47298813
77Collecting duct acid secretion_Homo sapiens_hsa049660.47073282
78Pyruvate metabolism_Homo sapiens_hsa006200.46358569
79Fatty acid elongation_Homo sapiens_hsa000620.44773846
80T cell receptor signaling pathway_Homo sapiens_hsa046600.43810638
81Sulfur relay system_Homo sapiens_hsa041220.43092769
82Fat digestion and absorption_Homo sapiens_hsa049750.42850075
83Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.41705683
84Regulation of autophagy_Homo sapiens_hsa041400.40456254
85Vitamin digestion and absorption_Homo sapiens_hsa049770.39882527
86Olfactory transduction_Homo sapiens_hsa047400.39122831
87Alcoholism_Homo sapiens_hsa050340.38421686
88Herpes simplex infection_Homo sapiens_hsa051680.36128932
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35753363
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35615269
91Glutathione metabolism_Homo sapiens_hsa004800.34881939
92NF-kappa B signaling pathway_Homo sapiens_hsa040640.34674217
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.32700630
94Folate biosynthesis_Homo sapiens_hsa007900.31913953
95Fatty acid metabolism_Homo sapiens_hsa012120.31704656
96Epstein-Barr virus infection_Homo sapiens_hsa051690.30682990
97Fatty acid degradation_Homo sapiens_hsa000710.29642351
98Ether lipid metabolism_Homo sapiens_hsa005650.27750191
99Leishmaniasis_Homo sapiens_hsa051400.27398811
100Taste transduction_Homo sapiens_hsa047420.23853065

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