HNRNPA1P58

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of 5.8S rRNA (GO:0000460)5.27993771
2proteasome assembly (GO:0043248)4.90104584
3water-soluble vitamin biosynthetic process (GO:0042364)4.67291909
4DNA deamination (GO:0045006)4.61271632
5establishment of protein localization to mitochondrial membrane (GO:0090151)4.31802986
6positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.96389410
7ribosome assembly (GO:0042255)3.93762133
8negative regulation of telomere maintenance (GO:0032205)3.89473590
9base-excision repair, AP site formation (GO:0006285)3.85033240
10negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.83482125
11chaperone-mediated protein transport (GO:0072321)3.78279299
12rRNA modification (GO:0000154)3.73977117
13peptidyl-histidine modification (GO:0018202)3.73122094
14regulation of cellular amino acid metabolic process (GO:0006521)3.60826707
15regulation of immunoglobulin secretion (GO:0051023)3.59764111
16regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.55548787
17negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.50072778
18negative regulation of ligase activity (GO:0051352)3.50072778
19regulation of isotype switching to IgG isotypes (GO:0048302)3.49094756
20cullin deneddylation (GO:0010388)3.48311401
21protein neddylation (GO:0045116)3.48159294
22RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.48149817
23tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.48149817
24mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.46195508
25ATP synthesis coupled proton transport (GO:0015986)3.45830951
26energy coupled proton transport, down electrochemical gradient (GO:0015985)3.45830951
27protein deneddylation (GO:0000338)3.44115738
28regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.44064170
29purine nucleobase biosynthetic process (GO:0009113)3.43833982
30positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.43684069
31DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.42277259
32signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.41021030
33signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.41021030
34signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.41021030
35nucleobase biosynthetic process (GO:0046112)3.35418265
36intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.33922461
37signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.33922461
38DNA replication-dependent nucleosome assembly (GO:0006335)3.30988114
39DNA replication-dependent nucleosome organization (GO:0034723)3.30988114
40anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.26788354
41signal transduction involved in DNA damage checkpoint (GO:0072422)3.26721001
42signal transduction involved in DNA integrity checkpoint (GO:0072401)3.26721001
43histone mRNA metabolic process (GO:0008334)3.25664358
44signal transduction involved in cell cycle checkpoint (GO:0072395)3.22579497
45spliceosomal snRNP assembly (GO:0000387)3.21981262
46cellular response to ATP (GO:0071318)3.18524672
47RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.17938894
48IMP biosynthetic process (GO:0006188)3.10364954
49DNA replication checkpoint (GO:0000076)3.09551747
50rRNA processing (GO:0006364)3.04384994
51mitochondrial respiratory chain complex I assembly (GO:0032981)3.01519959
52NADH dehydrogenase complex assembly (GO:0010257)3.01519959
53mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.01519959
54termination of RNA polymerase I transcription (GO:0006363)3.00876457
55rRNA methylation (GO:0031167)3.00868112
56maturation of SSU-rRNA (GO:0030490)3.00564290
57protein complex biogenesis (GO:0070271)3.00008678
58positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.99812839
59negative regulation of B cell apoptotic process (GO:0002903)2.98920180
60regulation of helicase activity (GO:0051095)2.98646468
61transcription elongation from RNA polymerase I promoter (GO:0006362)2.97556824
62rRNA metabolic process (GO:0016072)2.96420113
63DNA catabolic process, exonucleolytic (GO:0000738)2.93569308
64pseudouridine synthesis (GO:0001522)2.91049343
65pteridine-containing compound biosynthetic process (GO:0042559)2.87948004
66CENP-A containing nucleosome assembly (GO:0034080)2.87462327
67tRNA aminoacylation for protein translation (GO:0006418)2.87345649
68nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.85889181
69regulation of double-strand break repair via homologous recombination (GO:0010569)2.85488289
70mitochondrial respiratory chain complex assembly (GO:0033108)2.84018261
71positive regulation of ligase activity (GO:0051351)2.83941947
72exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.83076774
73chromatin remodeling at centromere (GO:0031055)2.81768229
74ncRNA catabolic process (GO:0034661)2.80816256
75purine nucleotide salvage (GO:0032261)2.80813262
76lactate metabolic process (GO:0006089)2.80395210
77positive regulation of isotype switching (GO:0045830)2.78434367
78pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.76797502
79regulation of ubiquitin-protein transferase activity (GO:0051438)2.76408817
80ribosome biogenesis (GO:0042254)2.74497882
81tRNA aminoacylation (GO:0043039)2.72364533
82amino acid activation (GO:0043038)2.72364533
83regulation of cellular amine metabolic process (GO:0033238)2.71872323
84ribosomal small subunit assembly (GO:0000028)2.71787291
85positive regulation of cell cycle arrest (GO:0071158)2.71563260
86GTP biosynthetic process (GO:0006183)2.69613575
87DNA double-strand break processing (GO:0000729)2.68065338
88negative regulation of T cell differentiation in thymus (GO:0033085)2.67545185
89resolution of meiotic recombination intermediates (GO:0000712)2.67451337
90tRNA processing (GO:0008033)2.66668814
91attachment of spindle microtubules to kinetochore (GO:0008608)2.66074118
92tryptophan metabolic process (GO:0006568)2.64711770
93negative regulation of DNA recombination (GO:0045910)2.64139144
94regulation of ligase activity (GO:0051340)2.64004789
95regulation of nuclear cell cycle DNA replication (GO:0033262)2.63792141
96positive regulation of DNA recombination (GO:0045911)2.63323155
97cellular ketone body metabolic process (GO:0046950)2.61769081
98L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.61628897
99protein K63-linked deubiquitination (GO:0070536)2.61275311
100tRNA metabolic process (GO:0006399)2.60646218

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.89568174
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.70815110
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.87915821
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.72994001
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.26736197
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.21339456
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.16566870
8E2F7_22180533_ChIP-Seq_HELA_Human3.13473120
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.88096465
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.84609103
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.83379922
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.73722738
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.62376196
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.59150740
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.57641392
16VDR_23849224_ChIP-Seq_CD4+_Human2.55592442
17ELK1_19687146_ChIP-ChIP_HELA_Human2.51958376
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.49744267
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.18692232
20FOXP3_21729870_ChIP-Seq_TREG_Human2.18250208
21VDR_22108803_ChIP-Seq_LS180_Human2.09865750
22ZNF274_21170338_ChIP-Seq_K562_Hela1.99295374
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.97467279
24PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.94017299
25POU5F1_16153702_ChIP-ChIP_HESCs_Human1.90692756
26PADI4_21655091_ChIP-ChIP_MCF-7_Human1.90683525
27MYC_18940864_ChIP-ChIP_HL60_Human1.90234388
28MYC_19030024_ChIP-ChIP_MESCs_Mouse1.85683027
29MYC_18358816_ChIP-ChIP_MESCs_Mouse1.85032123
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81302153
31EWS_26573619_Chip-Seq_HEK293_Human1.78402253
32CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.69289214
33HOXB4_20404135_ChIP-ChIP_EML_Mouse1.65402202
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65076204
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.64522160
36POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.63550129
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.61845494
38EGR1_23403033_ChIP-Seq_LIVER_Mouse1.53627143
39TTF2_22483619_ChIP-Seq_HELA_Human1.52933920
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.51308769
41DCP1A_22483619_ChIP-Seq_HELA_Human1.48279718
42GABP_19822575_ChIP-Seq_HepG2_Human1.47870913
43FUS_26573619_Chip-Seq_HEK293_Human1.43892423
44TAF15_26573619_Chip-Seq_HEK293_Human1.42808796
45MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.40405658
46IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.40374102
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.40130371
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39382040
49EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.36322866
50ELK1_22589737_ChIP-Seq_MCF10A_Human1.36276224
51FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.36055622
52HTT_18923047_ChIP-ChIP_STHdh_Human1.35259297
53NOTCH1_21737748_ChIP-Seq_TLL_Human1.29760118
54FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.29533844
55IGF1R_20145208_ChIP-Seq_DFB_Human1.29435958
56E2F1_18555785_ChIP-Seq_MESCs_Mouse1.27527234
57NELFA_20434984_ChIP-Seq_ESCs_Mouse1.27139129
58MYC_19079543_ChIP-ChIP_MESCs_Mouse1.25948881
59NANOG_16153702_ChIP-ChIP_HESCs_Human1.24712925
60SOX2_16153702_ChIP-ChIP_HESCs_Human1.23541033
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22669748
62GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.19910294
63HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.19628340
64CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.19396684
65TP53_22573176_ChIP-Seq_HFKS_Human1.18806465
66POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.18566584
67SOX2_19829295_ChIP-Seq_ESCs_Human1.18498581
68NANOG_19829295_ChIP-Seq_ESCs_Human1.18498581
69THAP11_20581084_ChIP-Seq_MESCs_Mouse1.17928725
70MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17532242
71P300_19829295_ChIP-Seq_ESCs_Human1.13356789
72POU3F2_20337985_ChIP-ChIP_501MEL_Human1.10451910
73MYCN_18555785_ChIP-Seq_MESCs_Mouse1.09666953
74IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.08000286
75EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07678825
76FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07575817
77FOXA1_25329375_ChIP-Seq_VCAP_Human1.07575817
78PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07031085
79SOX2_18555785_ChIP-Seq_MESCs_Mouse1.06036744
80YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05266950
81XRN2_22483619_ChIP-Seq_HELA_Human1.04559673
82PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.03197128
83NANOG_18555785_ChIP-Seq_MESCs_Mouse1.02517827
84SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00518057
85NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.97271741
86HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.96938063
87NFE2_27457419_Chip-Seq_LIVER_Mouse0.95548388
88SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95413419
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93664122
90ZFP57_27257070_Chip-Seq_ESCs_Mouse0.93567591
91CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.92024278
92RBPJ_22232070_ChIP-Seq_NCS_Mouse0.90162616
93ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.88513333
94EZH2_27294783_Chip-Seq_NPCs_Mouse0.88327348
95KLF5_20875108_ChIP-Seq_MESCs_Mouse0.88217150
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.87842640
97CBP_20019798_ChIP-Seq_JUKART_Human0.87842640
98CTBP2_25329375_ChIP-Seq_LNCAP_Human0.86256561
99CTBP1_25329375_ChIP-Seq_LNCAP_Human0.85108835
100PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.82274003

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.86668644
2MP0002102_abnormal_ear_morphology3.31087290
3MP0008058_abnormal_DNA_repair3.18254939
4MP0008877_abnormal_DNA_methylation2.70284455
5MP0008875_abnormal_xenobiotic_pharmacok2.63774561
6MP0003718_maternal_effect2.56845136
7MP0003890_abnormal_embryonic-extraembry2.48431908
8MP0004957_abnormal_blastocyst_morpholog2.43246529
9MP0003195_calcinosis2.38366152
10MP0009697_abnormal_copulation2.38110626
11MP0003806_abnormal_nucleotide_metabolis2.34673140
12MP0008057_abnormal_DNA_replication2.31580793
13MP0003786_premature_aging2.21611403
14MP0008007_abnormal_cellular_replicative2.18611893
15MP0006072_abnormal_retinal_apoptosis2.09831979
16MP0003567_abnormal_fetal_cardiomyocyte2.08143223
17MP0001984_abnormal_olfaction2.01103576
18MP0002736_abnormal_nociception_after1.92824107
19MP0001188_hyperpigmentation1.88762281
20MP0004147_increased_porphyrin_level1.82966854
21MP0006292_abnormal_olfactory_placode1.79709995
22MP0001529_abnormal_vocalization1.73027950
23MP0008872_abnormal_physiological_respon1.72970627
24MP0005408_hypopigmentation1.72354600
25MP0003111_abnormal_nucleus_morphology1.71840988
26MP0000372_irregular_coat_pigmentation1.70761976
27MP0008995_early_reproductive_senescence1.69057571
28MP0009333_abnormal_splenocyte_physiolog1.68115881
29MP0002938_white_spotting1.65161174
30MP0003787_abnormal_imprinting1.62911102
31MP0003880_abnormal_central_pattern1.61652303
32MP0001986_abnormal_taste_sensitivity1.58764344
33MP0001835_abnormal_antigen_presentation1.54355193
34MP0005084_abnormal_gallbladder_morpholo1.54112008
35MP0005423_abnormal_somatic_nervous1.53631565
36MP0001873_stomach_inflammation1.51526773
37MP0010094_abnormal_chromosome_stability1.50467502
38MP0002277_abnormal_respiratory_mucosa1.50277369
39MP0003077_abnormal_cell_cycle1.44353745
40MP0005671_abnormal_response_to1.41643821
41MP0002751_abnormal_autonomic_nervous1.40306298
42MP0001790_abnormal_immune_system1.39554664
43MP0005387_immune_system_phenotype1.39554664
44MP0010386_abnormal_urinary_bladder1.37765222
45MP0003119_abnormal_digestive_system1.36988155
46MP0004142_abnormal_muscle_tone1.35656034
47MP0003186_abnormal_redox_activity1.33652031
48MP0006035_abnormal_mitochondrial_morpho1.21029454
49MP0005253_abnormal_eye_physiology1.18971950
50MP0001968_abnormal_touch/_nociception1.17940368
51MP0006276_abnormal_autonomic_nervous1.16894379
52MP0003011_delayed_dark_adaptation1.14293372
53MP0005377_hearing/vestibular/ear_phenot1.11151893
54MP0003878_abnormal_ear_physiology1.11151893
55MP0003300_gastrointestinal_ulcer1.11140614
56MP0005395_other_phenotype1.08062010
57MP0001905_abnormal_dopamine_level1.06057078
58MP0005551_abnormal_eye_electrophysiolog1.05543704
59MP0002006_tumorigenesis1.04695583
60MP0002837_dystrophic_cardiac_calcinosis1.03131592
61MP0003283_abnormal_digestive_organ1.02417687
62MP0003646_muscle_fatigue1.01488595
63MP0004133_heterotaxia1.01472021
64MP0001764_abnormal_homeostasis1.01288038
65MP0002735_abnormal_chemical_nociception1.00455757
66MP0002638_abnormal_pupillary_reflex1.00222794
67MP0008789_abnormal_olfactory_epithelium0.94966939
68MP0005389_reproductive_system_phenotype0.92638652
69MP0005646_abnormal_pituitary_gland0.92521183
70MP0008932_abnormal_embryonic_tissue0.91329575
71MP0002234_abnormal_pharynx_morphology0.89153318
72MP0008873_increased_physiological_sensi0.88160364
73MP0002160_abnormal_reproductive_system0.87383688
74MP0001919_abnormal_reproductive_system0.85325846
75MP0005075_abnormal_melanosome_morpholog0.82494373
76MP0002148_abnormal_hypersensitivity_rea0.81529400
77MP0003137_abnormal_impulse_conducting0.80836839
78MP0005645_abnormal_hypothalamus_physiol0.80078187
79MP0002019_abnormal_tumor_incidence0.79981395
80MP0005636_abnormal_mineral_homeostasis0.79710320
81MP0004215_abnormal_myocardial_fiber0.79310504
82MP0005187_abnormal_penis_morphology0.78718929
83MP0003045_fibrosis0.77939055
84MP0002138_abnormal_hepatobiliary_system0.77752529
85MP0004742_abnormal_vestibular_system0.77273416
86MP0009785_altered_susceptibility_to0.75962948
87MP0000465_gastrointestinal_hemorrhage0.71286967
88MP0006036_abnormal_mitochondrial_physio0.71038272
89MP0001293_anophthalmia0.70877433
90MP0002693_abnormal_pancreas_physiology0.69843998
91MP0000358_abnormal_cell_content/0.69014031
92MP0002734_abnormal_mechanical_nocicepti0.68865939
93MP0002210_abnormal_sex_determination0.68840768
94MP0001853_heart_inflammation0.68352096
95MP0009379_abnormal_foot_pigmentation0.68138523
96MP0000647_abnormal_sebaceous_gland0.66811497
97MP0001929_abnormal_gametogenesis0.66694820
98MP0001119_abnormal_female_reproductive0.64732176
99MP0005085_abnormal_gallbladder_physiolo0.63689725
100MP0003221_abnormal_cardiomyocyte_apopto0.63097887

Predicted human phenotypes

RankGene SetZ-score
1Methylmalonic acidemia (HP:0002912)4.66380756
2Acute necrotizing encephalopathy (HP:0006965)4.04944479
3Acute encephalopathy (HP:0006846)3.80091145
4Hypoproteinemia (HP:0003075)3.78744065
5Methylmalonic aciduria (HP:0012120)3.68814209
6Abnormal mitochondria in muscle tissue (HP:0008316)3.43977821
7Progressive macrocephaly (HP:0004481)3.43079639
8Abnormality of the ileum (HP:0001549)3.39452573
9Meckel diverticulum (HP:0002245)3.37393578
10Reduced antithrombin III activity (HP:0001976)3.36342533
11Colon cancer (HP:0003003)3.27454958
12Aplasia/Hypoplasia of the uvula (HP:0010293)3.21530062
13Carpal bone hypoplasia (HP:0001498)3.21401146
14Hypoplasia of the pons (HP:0012110)3.19971390
15Hyperglycinemia (HP:0002154)3.17981654
16Increased hepatocellular lipid droplets (HP:0006565)3.10618188
17Increased CSF lactate (HP:0002490)3.08575411
18Type I transferrin isoform profile (HP:0003642)3.02679614
19Mitochondrial inheritance (HP:0001427)3.00079341
20Abnormality of the pons (HP:0007361)2.94273416
21Pancytopenia (HP:0001876)2.90437227
22Lipid accumulation in hepatocytes (HP:0006561)2.82464038
23Abnormality of the preputium (HP:0100587)2.82414595
24Pancreatic cysts (HP:0001737)2.79841697
25Abnormality of the vitamin B12 metabolism (HP:0004341)2.73963462
26Duodenal stenosis (HP:0100867)2.73564799
27Small intestinal stenosis (HP:0012848)2.73564799
28Stomatitis (HP:0010280)2.71945028
29Abnormality of DNA repair (HP:0003254)2.67180838
30Abnormality of the labia minora (HP:0012880)2.62551970
31Cerebral edema (HP:0002181)2.60963460
32IgG deficiency (HP:0004315)2.60043910
33Absent thumb (HP:0009777)2.58490684
34Abnormality of aspartate family amino acid metabolism (HP:0010899)2.58375264
35Abnormality of vitamin B metabolism (HP:0004340)2.54727500
36Abnormality of methionine metabolism (HP:0010901)2.52219993
373-Methylglutaconic aciduria (HP:0003535)2.51485014
38Spinal muscular atrophy (HP:0007269)2.50881065
39Aplasia/Hypoplasia involving the musculature (HP:0001460)2.48682435
40Abnormality of alanine metabolism (HP:0010916)2.45295902
41Hyperalaninemia (HP:0003348)2.45295902
42Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.45295902
43Abnormality of serum amino acid levels (HP:0003112)2.44636435
44Dicarboxylic aciduria (HP:0003215)2.44461373
45Abnormality of dicarboxylic acid metabolism (HP:0010995)2.44461373
46Abnormality of chromosome stability (HP:0003220)2.40477603
47Supernumerary spleens (HP:0009799)2.40211257
48Optic disc pallor (HP:0000543)2.39381124
49Abnormal protein N-linked glycosylation (HP:0012347)2.35467064
50Abnormal protein glycosylation (HP:0012346)2.35467064
51Abnormal glycosylation (HP:0012345)2.35467064
52Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.35467064
53Abnormality of the duodenum (HP:0002246)2.34281888
54Horseshoe kidney (HP:0000085)2.33695438
55Abnormality of glycine metabolism (HP:0010895)2.33000126
56Abnormality of serine family amino acid metabolism (HP:0010894)2.33000126
57Abnormal lung lobation (HP:0002101)2.32591708
58Abnormality of the carotid arteries (HP:0005344)2.31478805
59Pancreatic fibrosis (HP:0100732)2.23793970
60Hepatic necrosis (HP:0002605)2.20078820
61Clubbing of toes (HP:0100760)2.19932831
62Increased serum lactate (HP:0002151)2.18947940
63Increased intramyocellular lipid droplets (HP:0012240)2.18129754
64Chromosomal breakage induced by crosslinking agents (HP:0003221)2.17429058
65Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.15522921
66Exercise intolerance (HP:0003546)2.13725777
67Lactic acidosis (HP:0003128)2.11186672
68Lethargy (HP:0001254)2.11177043
69Bilateral microphthalmos (HP:0007633)2.10691416
70Hepatocellular necrosis (HP:0001404)2.07816631
71True hermaphroditism (HP:0010459)2.06364413
72Reticulocytopenia (HP:0001896)2.05829372
73Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.05415277
74Type 2 muscle fiber atrophy (HP:0003554)2.04157221
75Degeneration of anterior horn cells (HP:0002398)2.02965676
76Abnormality of the anterior horn cell (HP:0006802)2.02965676
77Leukodystrophy (HP:0002415)2.02098257
78Exertional dyspnea (HP:0002875)2.01418134
79Myelodysplasia (HP:0002863)2.00651244
80Increased IgM level (HP:0003496)1.98195704
81Hypothermia (HP:0002045)1.95115860
82Progressive inability to walk (HP:0002505)1.93677494
83Triphalangeal thumb (HP:0001199)1.91658206
84Hyperglycinuria (HP:0003108)1.90803054
85Chromsome breakage (HP:0040012)1.90406987
86Hypoglycemic coma (HP:0001325)1.87741445
87Abnormality of homocysteine metabolism (HP:0010919)1.82620046
88Homocystinuria (HP:0002156)1.82620046
89Multiple enchondromatosis (HP:0005701)1.82108169
90Generalized aminoaciduria (HP:0002909)1.81349960
91Renal Fanconi syndrome (HP:0001994)1.80106600
92Congenital stationary night blindness (HP:0007642)1.79798869
93Sloping forehead (HP:0000340)1.79090201
94Aplastic anemia (HP:0001915)1.78176993
95Oligohydramnios (HP:0001562)1.77859021
96Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.77507284
97Muscle fiber atrophy (HP:0100295)1.77270991
98Renal cortical cysts (HP:0000803)1.77040315
99Respiratory failure (HP:0002878)1.77022239
100Neoplasm of the adrenal gland (HP:0100631)1.75616046

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.97681727
2TSSK64.61690549
3ZAK4.33673371
4VRK23.47713869
5TLK12.58185765
6PBK2.44802993
7TRIM282.39588141
8EIF2AK32.36293541
9VRK12.29954221
10SRPK12.23905599
11NME12.08318069
12MST42.03262423
13PASK1.99803156
14MKNK11.96130803
15PLK31.84868032
16CDC71.83812858
17TXK1.83113684
18KDR1.80605924
19WNK31.70258959
20MKNK21.66913752
21GRK11.62196235
22ADRBK21.53798882
23TTK1.47616938
24AKT31.39342650
25MAP4K21.37787038
26MAP3K101.37588921
27TNIK1.37502937
28BCKDK1.35460956
29PINK11.27878815
30FRK1.20726355
31TAF11.19183902
32ITK1.13824727
33RPS6KA51.13275418
34EIF2AK11.12327125
35ATR1.10631767
36JAK31.10527209
37NUAK11.06611142
38WEE11.05843259
39DYRK21.04674685
40STK41.00357885
41PLK40.94064671
42ACVR1B0.93386785
43CAMKK20.93255441
44PLK10.92929542
45CSNK1G30.87794902
46SIK30.86374847
47BCR0.82960863
48STK160.82328902
49BMPR1B0.81211264
50PLK20.80305194
51CSNK1A1L0.77619372
52TIE10.77192846
53CSNK1G10.76793887
54IKBKE0.76524365
55DYRK30.75146195
56CHEK20.72156932
57TGFBR10.67850643
58PNCK0.67512031
59CSNK1G20.67055817
60IKBKB0.66224222
61NEK10.65988617
62ERBB30.64121345
63DAPK20.62614360
64OXSR10.62185567
65INSRR0.62001954
66MAP2K70.59995152
67AURKB0.58934556
68TEC0.53848854
69PAK40.52508694
70MAP4K10.51410274
71NEK90.50754333
72ALK0.50680763
73DAPK10.47860314
74PDK20.47279523
75ATM0.46626697
76CSNK2A20.44966129
77KIT0.43728792
78PRKCE0.43091310
79CSNK1A10.41672364
80BRSK20.40919793
81CSNK2A10.39848669
82AURKA0.39686984
83WNK40.39436195
84FGFR10.37376003
85PRKCG0.34012772
86CSNK1E0.33936752
87CLK10.33818984
88LYN0.33757558
89BRAF0.32827367
90IGF1R0.29867515
91PIK3CG0.28408387
92DAPK30.25834659
93ERBB20.25819356
94CHEK10.23896099
95PRKCA0.23831109
96PRKDC0.22392804
97PRKACA0.20519871
98MAP3K120.20332989
99STK390.19283101
100PIM10.18901883

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.64674712
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.42584254
3Mismatch repair_Homo sapiens_hsa034302.63980037
4Oxidative phosphorylation_Homo sapiens_hsa001902.62987124
5Basal transcription factors_Homo sapiens_hsa030222.36605150
6Protein export_Homo sapiens_hsa030602.30407057
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.29714995
8Homologous recombination_Homo sapiens_hsa034402.16974978
9One carbon pool by folate_Homo sapiens_hsa006702.11503268
10Parkinsons disease_Homo sapiens_hsa050122.08184214
11Ribosome_Homo sapiens_hsa030102.05716642
12RNA polymerase_Homo sapiens_hsa030202.04265333
13DNA replication_Homo sapiens_hsa030302.03756102
14Base excision repair_Homo sapiens_hsa034101.99141399
15Non-homologous end-joining_Homo sapiens_hsa034501.96125230
16Nucleotide excision repair_Homo sapiens_hsa034201.94457955
17RNA transport_Homo sapiens_hsa030131.91818226
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.89309101
19Propanoate metabolism_Homo sapiens_hsa006401.81083501
20Systemic lupus erythematosus_Homo sapiens_hsa053221.68553529
21RNA degradation_Homo sapiens_hsa030181.68490779
22Fanconi anemia pathway_Homo sapiens_hsa034601.60470238
23Spliceosome_Homo sapiens_hsa030401.58816291
24Asthma_Homo sapiens_hsa053101.44046419
25Steroid biosynthesis_Homo sapiens_hsa001001.40278220
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.40273969
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.39793179
28Allograft rejection_Homo sapiens_hsa053301.36531318
29Huntingtons disease_Homo sapiens_hsa050161.36212383
30Nitrogen metabolism_Homo sapiens_hsa009101.34300417
31Autoimmune thyroid disease_Homo sapiens_hsa053201.33990217
32Tryptophan metabolism_Homo sapiens_hsa003801.29173099
33Pyrimidine metabolism_Homo sapiens_hsa002401.26533618
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.23695888
35Purine metabolism_Homo sapiens_hsa002301.22306078
36Butanoate metabolism_Homo sapiens_hsa006501.19805789
37Peroxisome_Homo sapiens_hsa041461.19549424
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.19339919
39Selenocompound metabolism_Homo sapiens_hsa004501.18934771
40Alzheimers disease_Homo sapiens_hsa050101.18580896
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.17027256
42Maturity onset diabetes of the young_Homo sapiens_hsa049501.13317132
43Fatty acid elongation_Homo sapiens_hsa000621.07179050
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.06351300
45Type I diabetes mellitus_Homo sapiens_hsa049401.06292029
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05397095
47Pyruvate metabolism_Homo sapiens_hsa006201.01565284
48Primary bile acid biosynthesis_Homo sapiens_hsa001201.00475238
49Primary immunodeficiency_Homo sapiens_hsa053401.00366409
50Phototransduction_Homo sapiens_hsa047440.98603098
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.94450047
52Biosynthesis of amino acids_Homo sapiens_hsa012300.94096371
53beta-Alanine metabolism_Homo sapiens_hsa004100.92629637
54Vitamin B6 metabolism_Homo sapiens_hsa007500.89990645
55Intestinal immune network for IgA production_Homo sapiens_hsa046720.86731622
56Sulfur metabolism_Homo sapiens_hsa009200.86597155
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86497290
58Carbon metabolism_Homo sapiens_hsa012000.85327125
59Alcoholism_Homo sapiens_hsa050340.84978662
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.84123801
61Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.83659870
62Graft-versus-host disease_Homo sapiens_hsa053320.83243686
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.79991596
64Vitamin digestion and absorption_Homo sapiens_hsa049770.78223524
65Arginine and proline metabolism_Homo sapiens_hsa003300.76551343
66Rheumatoid arthritis_Homo sapiens_hsa053230.72895577
67Collecting duct acid secretion_Homo sapiens_hsa049660.72654101
68Antigen processing and presentation_Homo sapiens_hsa046120.72029896
69Cardiac muscle contraction_Homo sapiens_hsa042600.65488664
70Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.65198380
71Glutathione metabolism_Homo sapiens_hsa004800.64336395
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62416921
73Metabolic pathways_Homo sapiens_hsa011000.61060416
74Histidine metabolism_Homo sapiens_hsa003400.59337406
75Hematopoietic cell lineage_Homo sapiens_hsa046400.56933185
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56511303
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54546705
78Cell cycle_Homo sapiens_hsa041100.54441427
79Linoleic acid metabolism_Homo sapiens_hsa005910.54352525
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53638977
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53554209
82Caffeine metabolism_Homo sapiens_hsa002320.53371571
83ABC transporters_Homo sapiens_hsa020100.48123706
84Fat digestion and absorption_Homo sapiens_hsa049750.46833947
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46699873
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46498722
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.45377041
88Measles_Homo sapiens_hsa051620.43786616
89Chemical carcinogenesis_Homo sapiens_hsa052040.43659204
90Retinol metabolism_Homo sapiens_hsa008300.41772832
91Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.41547228
92Fatty acid degradation_Homo sapiens_hsa000710.41359483
93Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.41270931
94Viral carcinogenesis_Homo sapiens_hsa052030.35919392
95Glycerolipid metabolism_Homo sapiens_hsa005610.35326181
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.34922800
97Olfactory transduction_Homo sapiens_hsa047400.31259942
98Epstein-Barr virus infection_Homo sapiens_hsa051690.30865191
99Taste transduction_Homo sapiens_hsa047420.28436144
100mRNA surveillance pathway_Homo sapiens_hsa030150.28241696

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »