HNRNPA1P55

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1rRNA modification (GO:0000154)5.00267570
2rRNA methylation (GO:0031167)4.94726267
3ribosomal large subunit biogenesis (GO:0042273)4.74937003
4DNA deamination (GO:0045006)4.63057270
5proteasome assembly (GO:0043248)4.48159229
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.25816107
7ribosomal small subunit assembly (GO:0000028)4.24147383
8ATP synthesis coupled proton transport (GO:0015986)4.17326632
9energy coupled proton transport, down electrochemical gradient (GO:0015985)4.17326632
10GMP metabolic process (GO:0046037)3.90079463
11maturation of SSU-rRNA (GO:0030490)3.82651214
12nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.80341713
13exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.76368580
14regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.74062982
15regulation of mitotic spindle checkpoint (GO:1903504)3.74062982
16protein neddylation (GO:0045116)3.74007522
17DNA damage response, detection of DNA damage (GO:0042769)3.61262587
18cullin deneddylation (GO:0010388)3.58078660
19mitochondrial respiratory chain complex I assembly (GO:0032981)3.55596722
20NADH dehydrogenase complex assembly (GO:0010257)3.55596722
21mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.55596722
22mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.55256333
23water-soluble vitamin biosynthetic process (GO:0042364)3.53534908
24L-fucose catabolic process (GO:0042355)3.45717860
25fucose catabolic process (GO:0019317)3.45717860
26L-fucose metabolic process (GO:0042354)3.45717860
27viral transcription (GO:0019083)3.45592144
28establishment of protein localization to mitochondrial membrane (GO:0090151)3.44310983
29translational termination (GO:0006415)3.41248049
30protein deneddylation (GO:0000338)3.30528591
31protein complex biogenesis (GO:0070271)3.30035137
32positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.29536691
33rRNA catabolic process (GO:0016075)3.28715568
34SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.28025571
35negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.27484808
36histone mRNA metabolic process (GO:0008334)3.25413052
37mitochondrial respiratory chain complex assembly (GO:0033108)3.23526878
38purine nucleobase biosynthetic process (GO:0009113)3.22845633
39cotranslational protein targeting to membrane (GO:0006613)3.21231271
40nucleobase biosynthetic process (GO:0046112)3.20818323
41protein targeting to ER (GO:0045047)3.18609274
42IMP biosynthetic process (GO:0006188)3.18592262
43RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.15109194
44regulation of cellular amino acid metabolic process (GO:0006521)3.14776174
45translational elongation (GO:0006414)3.09826779
46IMP metabolic process (GO:0046040)3.09096685
47DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.07384789
48regulation of isotype switching to IgG isotypes (GO:0048302)3.06545536
49establishment of protein localization to endoplasmic reticulum (GO:0072599)3.06072453
50chromatin remodeling at centromere (GO:0031055)3.04994804
51signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.04676239
52signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.04676239
53signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.04676239
54termination of RNA polymerase III transcription (GO:0006386)3.02954900
55transcription elongation from RNA polymerase III promoter (GO:0006385)3.02954900
56rRNA processing (GO:0006364)2.99716837
57intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.99252767
58signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.99252767
59protein localization to endoplasmic reticulum (GO:0070972)2.98659292
60rRNA metabolic process (GO:0016072)2.98625283
61protein-cofactor linkage (GO:0018065)2.98453000
62translational initiation (GO:0006413)2.96460921
63CENP-A containing nucleosome assembly (GO:0034080)2.95291883
64ribosome assembly (GO:0042255)2.95249799
65folic acid-containing compound biosynthetic process (GO:0009396)2.94934785
66negative regulation of ligase activity (GO:0051352)2.94665664
67negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.94665664
68translation (GO:0006412)2.94003262
69DNA excision (GO:0044349)2.92816175
70nucleotide-excision repair, DNA damage removal (GO:0000718)2.92816175
71electron transport chain (GO:0022900)2.90489337
72regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.89667201
73positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.89488984
74maturation of 5.8S rRNA (GO:0000460)2.89201778
75signal transduction involved in DNA damage checkpoint (GO:0072422)2.88955680
76signal transduction involved in DNA integrity checkpoint (GO:0072401)2.88955680
77regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.88836661
78respiratory electron transport chain (GO:0022904)2.87745523
79protein K6-linked ubiquitination (GO:0085020)2.86243806
80signal transduction involved in cell cycle checkpoint (GO:0072395)2.85758409
81pyrimidine ribonucleoside catabolic process (GO:0046133)2.85067790
82spliceosomal snRNP assembly (GO:0000387)2.84146608
83regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.83332814
84regulation of mitochondrial translation (GO:0070129)2.82217984
85tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.80128706
86RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.80128706
87somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.80063241
88isotype switching (GO:0045190)2.80063241
89somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.80063241
90mannosylation (GO:0097502)2.77773197
91resolution of meiotic recombination intermediates (GO:0000712)2.77161755
92tRNA processing (GO:0008033)2.76995071
93somatic hypermutation of immunoglobulin genes (GO:0016446)2.74704889
94somatic diversification of immune receptors via somatic mutation (GO:0002566)2.74704889
95spliceosomal complex assembly (GO:0000245)2.74055027
96anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.73642955
97ribonucleoprotein complex biogenesis (GO:0022613)2.71707045
98DNA replication checkpoint (GO:0000076)2.71239822
99nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.70928484
100transcription from mitochondrial promoter (GO:0006390)2.70478026

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.88541084
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.59972531
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.93320032
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.48768227
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.24576144
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.13434033
7VDR_23849224_ChIP-Seq_CD4+_Human2.95232121
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.91097601
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.73328967
10VDR_22108803_ChIP-Seq_LS180_Human2.71819694
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.66359184
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.61818043
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.60977629
14ELK1_19687146_ChIP-ChIP_HELA_Human2.58108161
15FOXP3_21729870_ChIP-Seq_TREG_Human2.48847529
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.47890851
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.41333802
18ZNF274_21170338_ChIP-Seq_K562_Hela2.32646547
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.32545211
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.30918613
21EWS_26573619_Chip-Seq_HEK293_Human2.20281172
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.14364477
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.99614171
24TTF2_22483619_ChIP-Seq_HELA_Human1.90053502
25TAF15_26573619_Chip-Seq_HEK293_Human1.87911688
26MYC_18940864_ChIP-ChIP_HL60_Human1.87728999
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.86697800
28SRF_21415370_ChIP-Seq_HL-1_Mouse1.83234953
29PADI4_21655091_ChIP-ChIP_MCF-7_Human1.81551715
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77156604
31FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.76579063
32MYC_18358816_ChIP-ChIP_MESCs_Mouse1.74288765
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72828357
34MYC_19030024_ChIP-ChIP_MESCs_Mouse1.67187041
35MYC_19079543_ChIP-ChIP_MESCs_Mouse1.64982483
36DCP1A_22483619_ChIP-Seq_HELA_Human1.59404268
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.58139033
38IRF1_19129219_ChIP-ChIP_H3396_Human1.55799973
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55433221
40FUS_26573619_Chip-Seq_HEK293_Human1.52636193
41HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.50806871
42PCGF2_27294783_Chip-Seq_NPCs_Mouse1.44089150
43P300_19829295_ChIP-Seq_ESCs_Human1.43127141
44EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.42409408
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.40649782
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38722801
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.32711654
48IGF1R_20145208_ChIP-Seq_DFB_Human1.32594053
49POU5F1_16153702_ChIP-ChIP_HESCs_Human1.32114999
50GABP_19822575_ChIP-Seq_HepG2_Human1.31689728
51E2F1_18555785_ChIP-Seq_MESCs_Mouse1.31497068
52ER_23166858_ChIP-Seq_MCF-7_Human1.28984175
53PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.27980658
54ELK1_22589737_ChIP-Seq_MCF10A_Human1.24351933
55XRN2_22483619_ChIP-Seq_HELA_Human1.21521936
56SOX2_19829295_ChIP-Seq_ESCs_Human1.21263385
57NANOG_19829295_ChIP-Seq_ESCs_Human1.21263385
58POU3F2_20337985_ChIP-ChIP_501MEL_Human1.19459540
59MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19346962
60IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.17860935
61TP53_22573176_ChIP-Seq_HFKS_Human1.17855663
62CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17016572
63ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.16751527
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.16070970
65CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.14581036
66FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.14110075
67AR_20517297_ChIP-Seq_VCAP_Human1.12972616
68NFE2_27457419_Chip-Seq_LIVER_Mouse1.12961630
69YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11207333
70FOXA1_27270436_Chip-Seq_PROSTATE_Human1.09453001
71FOXA1_25329375_ChIP-Seq_VCAP_Human1.09453001
72THAP11_20581084_ChIP-Seq_MESCs_Mouse1.08988462
73EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.08527202
74EZH2_27294783_Chip-Seq_NPCs_Mouse1.06808793
75ZFP57_27257070_Chip-Seq_ESCs_Mouse1.04789315
76GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03942552
77SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03628270
78NELFA_20434984_ChIP-Seq_ESCs_Mouse0.99182948
79ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.97711289
80PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.96719244
81MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.96644708
82NANOG_16153702_ChIP-ChIP_HESCs_Human0.96259695
83SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.95517922
84BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94317604
85POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.93342511
86AUTS2_25519132_ChIP-Seq_293T-REX_Human0.92672115
87KLF5_20875108_ChIP-Seq_MESCs_Mouse0.91653849
88CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.90516804
89FOXA1_21572438_ChIP-Seq_LNCaP_Human0.89451752
90CRX_20693478_ChIP-Seq_RETINA_Mouse0.89420477
91CBP_20019798_ChIP-Seq_JUKART_Human0.88282369
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.88282369
93FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.86950112
94CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86452832
95E2F7_22180533_ChIP-Seq_HELA_Human0.85453448
96KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.84696315
97NCOR_22424771_ChIP-Seq_293T_Human0.82788963
98STAT3_18555785_Chip-Seq_ESCs_Mouse0.82187626
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.81773419
100IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.80824394

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006072_abnormal_retinal_apoptosis3.42523390
2MP0005646_abnormal_pituitary_gland3.12789611
3MP0005645_abnormal_hypothalamus_physiol2.95722562
4MP0003693_abnormal_embryo_hatching2.94715625
5MP0002102_abnormal_ear_morphology2.86067258
6MP0008877_abnormal_DNA_methylation2.76990860
7MP0001835_abnormal_antigen_presentation2.63429191
8MP0008058_abnormal_DNA_repair2.58025101
9MP0003806_abnormal_nucleotide_metabolis2.53925556
10MP0006292_abnormal_olfactory_placode2.40917364
11MP0003283_abnormal_digestive_organ2.24689249
12MP0005084_abnormal_gallbladder_morpholo2.23755921
13MP0002234_abnormal_pharynx_morphology2.10539903
14MP0005671_abnormal_response_to2.07441536
15MP0009697_abnormal_copulation2.06784327
16MP0004957_abnormal_blastocyst_morpholog2.02949212
17MP0003567_abnormal_fetal_cardiomyocyte2.00916161
18MP0010094_abnormal_chromosome_stability1.99301141
19MP0005551_abnormal_eye_electrophysiolog1.98834177
20MP0001293_anophthalmia1.97085542
21MP0009379_abnormal_foot_pigmentation1.95354337
22MP0001764_abnormal_homeostasis1.95230007
23MP0001873_stomach_inflammation1.79428012
24MP0002837_dystrophic_cardiac_calcinosis1.70080197
25MP0003786_premature_aging1.69423906
26MP0005253_abnormal_eye_physiology1.64339926
27MP0008872_abnormal_physiological_respon1.54436583
28MP0003195_calcinosis1.53127556
29MP0004147_increased_porphyrin_level1.50785340
30MP0004885_abnormal_endolymph1.47646807
31MP0003011_delayed_dark_adaptation1.44089025
32MP0004145_abnormal_muscle_electrophysio1.41122167
33MP0003186_abnormal_redox_activity1.41085195
34MP0009785_altered_susceptibility_to1.37446021
35MP0003718_maternal_effect1.36654282
36MP0002736_abnormal_nociception_after1.36234301
37MP0006276_abnormal_autonomic_nervous1.32984979
38MP0004142_abnormal_muscle_tone1.32975882
39MP0006035_abnormal_mitochondrial_morpho1.30959579
40MP0004742_abnormal_vestibular_system1.28342842
41MP0000631_abnormal_neuroendocrine_gland1.27542463
42MP0001501_abnormal_sleep_pattern1.21769179
43MP0001853_heart_inflammation1.21262897
44MP0002751_abnormal_autonomic_nervous1.18796165
45MP0005387_immune_system_phenotype1.16664594
46MP0001790_abnormal_immune_system1.16664594
47MP0006036_abnormal_mitochondrial_physio1.15519969
48MP0008875_abnormal_xenobiotic_pharmacok1.15265890
49MP0009333_abnormal_splenocyte_physiolog1.13697519
50MP0002148_abnormal_hypersensitivity_rea1.12847795
51MP0003111_abnormal_nucleus_morphology1.08053730
52MP0003878_abnormal_ear_physiology1.06974025
53MP0005377_hearing/vestibular/ear_phenot1.06974025
54MP0001529_abnormal_vocalization1.06308163
55MP0001881_abnormal_mammary_gland1.05009104
56MP0004782_abnormal_surfactant_physiolog1.04492565
57MP0008932_abnormal_embryonic_tissue0.99726547
58MP0001968_abnormal_touch/_nociception0.99435596
59MP0000049_abnormal_middle_ear0.97119576
60MP0003880_abnormal_central_pattern0.96831948
61MP0008007_abnormal_cellular_replicative0.95591605
62MP0005332_abnormal_amino_acid0.94443547
63MP0001485_abnormal_pinna_reflex0.93796512
64MP0005389_reproductive_system_phenotype0.93254019
65MP0003077_abnormal_cell_cycle0.89377691
66MP0001986_abnormal_taste_sensitivity0.88499928
67MP0005410_abnormal_fertilization0.88167684
68MP0000685_abnormal_immune_system0.86447757
69MP0010155_abnormal_intestine_physiology0.84409234
70MP0003045_fibrosis0.83786422
71MP0001919_abnormal_reproductive_system0.82519275
72MP0001984_abnormal_olfaction0.82453272
73MP0005083_abnormal_biliary_tract0.82150394
74MP0001929_abnormal_gametogenesis0.80920517
75MP0002282_abnormal_trachea_morphology0.80228824
76MP0003119_abnormal_digestive_system0.80178409
77MP0009765_abnormal_xenobiotic_induced0.78632241
78MP0005085_abnormal_gallbladder_physiolo0.78402955
79MP0002277_abnormal_respiratory_mucosa0.78256065
80MP0002210_abnormal_sex_determination0.78247283
81MP0004215_abnormal_myocardial_fiber0.77878273
82MP0005636_abnormal_mineral_homeostasis0.77368050
83MP0002138_abnormal_hepatobiliary_system0.77146259
84MP0008789_abnormal_olfactory_epithelium0.76757713
85MP0008995_early_reproductive_senescence0.76122979
86MP0004019_abnormal_vitamin_homeostasis0.74426534
87MP0001800_abnormal_humoral_immune0.73400658
88MP0002006_tumorigenesis0.73089174
89MP0001286_abnormal_eye_development0.70039701
90MP0002019_abnormal_tumor_incidence0.69910327
91MP0002405_respiratory_system_inflammati0.69096061
92MP0005391_vision/eye_phenotype0.69066879
93MP0005195_abnormal_posterior_eye0.68312173
94MP0000653_abnormal_sex_gland0.68305760
95MP0008775_abnormal_heart_ventricle0.66332827
96MP0001119_abnormal_female_reproductive0.66064029
97MP0009764_decreased_sensitivity_to0.65318232
98MP0005000_abnormal_immune_tolerance0.64620422
99MP0003698_abnormal_male_reproductive0.64571696
100MP0002272_abnormal_nervous_system0.62631717

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.24534364
2Acute encephalopathy (HP:0006846)3.87736938
3Mitochondrial inheritance (HP:0001427)3.74116202
4Methylmalonic acidemia (HP:0002912)3.68432815
5Abnormal mitochondria in muscle tissue (HP:0008316)3.66398254
6Congenital, generalized hypertrichosis (HP:0004540)3.54747945
7Stomatitis (HP:0010280)3.53484228
8Progressive macrocephaly (HP:0004481)3.50978512
9Increased CSF lactate (HP:0002490)3.38539191
10Hypoproteinemia (HP:0003075)3.36365731
11Type I transferrin isoform profile (HP:0003642)3.05868172
12Hepatocellular necrosis (HP:0001404)3.03409169
13Cerebral edema (HP:0002181)3.00523398
14Colon cancer (HP:0003003)2.99806326
15Pancreatic cysts (HP:0001737)2.95217291
16Increased hepatocellular lipid droplets (HP:0006565)2.87821347
17Panhypogammaglobulinemia (HP:0003139)2.87531784
18Increased serum pyruvate (HP:0003542)2.86041582
19Hepatic necrosis (HP:0002605)2.85036557
20Methylmalonic aciduria (HP:0012120)2.76901874
21Nephronophthisis (HP:0000090)2.76134882
22Attenuation of retinal blood vessels (HP:0007843)2.74221348
23IgG deficiency (HP:0004315)2.72092043
24Renal cortical cysts (HP:0000803)2.71387667
25Hyperglycinemia (HP:0002154)2.69556087
26Hypoplasia of the pons (HP:0012110)2.68062406
27Optic disc pallor (HP:0000543)2.60649120
28Abnormality of the pons (HP:0007361)2.59577087
29Abnormality of cells of the erythroid lineage (HP:0012130)2.59090152
30B lymphocytopenia (HP:0010976)2.53333837
31Lipid accumulation in hepatocytes (HP:0006561)2.50739836
32Abnormality of the renal cortex (HP:0011035)2.49712912
33Abnormality of midbrain morphology (HP:0002418)2.49399368
34Molar tooth sign on MRI (HP:0002419)2.49399368
35Abnormal number of erythroid precursors (HP:0012131)2.48076367
36Increased serum lactate (HP:0002151)2.47227416
37Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.46947659
38Abnormality of alanine metabolism (HP:0010916)2.46947659
39Hyperalaninemia (HP:0003348)2.46947659
40Abnormality of DNA repair (HP:0003254)2.46069560
41Aplasia/Hypoplasia of the uvula (HP:0010293)2.44663969
423-Methylglutaconic aciduria (HP:0003535)2.43555624
43Reduced antithrombin III activity (HP:0001976)2.42970102
44Congenital stationary night blindness (HP:0007642)2.41589964
45Meckel diverticulum (HP:0002245)2.41381542
46Type 2 muscle fiber atrophy (HP:0003554)2.39835394
47Reticulocytopenia (HP:0001896)2.37385919
48Abnormality of the ileum (HP:0001549)2.37236817
49Pendular nystagmus (HP:0012043)2.36567451
50Lactic acidosis (HP:0003128)2.32451591
51Pancreatic fibrosis (HP:0100732)2.32272559
52Hypochromic microcytic anemia (HP:0004840)2.31143288
53Absent rod-and cone-mediated responses on ERG (HP:0007688)2.30062493
54Abnormality of B cell number (HP:0010975)2.29717625
55Abnormal protein glycosylation (HP:0012346)2.29118499
56Abnormal glycosylation (HP:0012345)2.29118499
57Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.29118499
58Abnormal protein N-linked glycosylation (HP:0012347)2.29118499
59Triphalangeal thumb (HP:0001199)2.26329420
60True hermaphroditism (HP:0010459)2.26161120
61Abnormality of aspartate family amino acid metabolism (HP:0010899)2.23801890
62Decreased electroretinogram (ERG) amplitude (HP:0000654)2.23787733
63Hyperglycinuria (HP:0003108)2.22224045
64Abnormal rod and cone electroretinograms (HP:0008323)2.22163628
65Macrocytic anemia (HP:0001972)2.22160386
66Bilateral microphthalmos (HP:0007633)2.21337724
67Abnormality of glycolysis (HP:0004366)2.20732857
68Abnormality of glycine metabolism (HP:0010895)2.20384500
69Abnormality of serine family amino acid metabolism (HP:0010894)2.20384500
70Abolished electroretinogram (ERG) (HP:0000550)2.19518170
71Microvesicular hepatic steatosis (HP:0001414)2.17433908
72Abnormality of serum amino acid levels (HP:0003112)2.17055561
73Renal Fanconi syndrome (HP:0001994)2.11518164
74Abnormality of the vitamin B12 metabolism (HP:0004341)2.09574499
75Abnormality of the renal medulla (HP:0100957)2.09451005
76Leukodystrophy (HP:0002415)2.08250793
77Lethargy (HP:0001254)2.06469862
78Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.06081718
79Cleft eyelid (HP:0000625)2.01477586
80Absent thumb (HP:0009777)2.01426372
81Aplastic anemia (HP:0001915)2.00573425
82Exercise intolerance (HP:0003546)1.99838928
83Respiratory failure (HP:0002878)1.97809302
84Exertional dyspnea (HP:0002875)1.96065976
85Constricted visual fields (HP:0001133)1.95199111
86Abnormality of methionine metabolism (HP:0010901)1.93482469
87Abnormality of vitamin B metabolism (HP:0004340)1.92712502
88Medial flaring of the eyebrow (HP:0010747)1.91815438
89Abnormal pupillary function (HP:0007686)1.91504681
90Muscle fiber atrophy (HP:0100295)1.88690173
91Abnormal biliary tract physiology (HP:0012439)1.83354950
92Bile duct proliferation (HP:0001408)1.83354950
93Dyschromatopsia (HP:0007641)1.80148014
94Tubular atrophy (HP:0000092)1.74578383
95Pancytopenia (HP:0001876)1.74295069
96Abnormality of the preputium (HP:0100587)1.73996626
97Severe combined immunodeficiency (HP:0004430)1.73933951
98Chorioretinal atrophy (HP:0000533)1.72727153
99Duodenal stenosis (HP:0100867)1.70887450
100Small intestinal stenosis (HP:0012848)1.70887450

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK3.77537885
2ZAK3.14007586
3NUAK13.04654497
4VRK23.01818559
5EIF2AK32.55304201
6SRPK12.27010960
7MKNK12.25424091
8NME12.24967291
9NEK92.21265055
10VRK12.15679088
11WNK32.13945557
12TLK12.13931453
13TSSK62.13598724
14BUB12.11076354
15TRIM282.09248729
16TAF12.04847571
17NEK12.02832133
18CDK191.96971144
19PLK31.77630554
20TEC1.70777919
21BCKDK1.70210615
22BMPR1B1.70161504
23MST41.59908662
24RPS6KA41.56628299
25ADRBK21.56177971
26GRK11.55743064
27PLK41.50231556
28TIE11.41077406
29PASK1.37290148
30CDC71.34638665
31MAP4K21.33397253
32STK161.32296619
33PBK1.29642862
34TAOK31.26642398
35EIF2AK21.21734802
36MAP4K11.18557811
37BCR1.15421210
38CSNK1G31.14016580
39MKNK21.13593910
40FES1.11480617
41CSNK1G21.08159054
42DYRK21.06767431
43OXSR11.03741993
44TNIK1.01619666
45CSNK1G11.01097857
46IKBKB0.95138647
47RPS6KA50.93048414
48TNK20.92644316
49CAMKK20.90689540
50CSNK1A1L0.89510378
51ITK0.88408273
52PINK10.88087778
53PLK10.86807146
54STK38L0.83775279
55ACVR1B0.81386272
56TGFBR10.72735096
57MAPK130.71371748
58FRK0.70332743
59NME20.69652637
60SYK0.69230869
61GRK70.68830202
62NEK20.65573070
63ATR0.65031001
64PLK20.64897088
65TTK0.63363257
66CDK30.59600187
67MAP2K60.58936265
68PRKCQ0.57101068
69CSNK2A20.56617124
70IKBKE0.56084312
71INSRR0.55833141
72PRKCE0.55255882
73AURKB0.53533845
74ALK0.53491288
75LYN0.51545727
76CSNK2A10.49953072
77BTK0.49516873
78BRSK20.48815649
79WNK40.47483561
80CSNK1A10.46926480
81PTK2B0.45567082
82MAPKAPK50.45523744
83EIF2AK10.45427732
84ADRBK10.44984348
85KDR0.40060013
86ATM0.38205228
87PIK3CA0.36834267
88IGF1R0.36672628
89WEE10.36542537
90FLT30.36354162
91PAK30.35650445
92MUSK0.33531514
93CHEK20.31775083
94MAP2K70.31087844
95LCK0.30461222
96KIT0.30346601
97PRKACA0.30190744
98CAMK10.29918894
99OBSCN0.27330061
100CSF1R0.26893415

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.25475060
2Ribosome_Homo sapiens_hsa030103.42483232
3Oxidative phosphorylation_Homo sapiens_hsa001902.97409811
4Protein export_Homo sapiens_hsa030602.94272884
5Mismatch repair_Homo sapiens_hsa034302.59352858
6Parkinsons disease_Homo sapiens_hsa050122.52924998
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.46062792
8One carbon pool by folate_Homo sapiens_hsa006702.45416288
9Homologous recombination_Homo sapiens_hsa034402.39635594
10RNA polymerase_Homo sapiens_hsa030202.21879434
11Nucleotide excision repair_Homo sapiens_hsa034202.08718650
12Non-homologous end-joining_Homo sapiens_hsa034502.06997072
13Propanoate metabolism_Homo sapiens_hsa006402.05412328
14Phototransduction_Homo sapiens_hsa047441.96491180
15DNA replication_Homo sapiens_hsa030301.96425361
16Allograft rejection_Homo sapiens_hsa053301.93007738
17Primary immunodeficiency_Homo sapiens_hsa053401.86295356
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.82087918
19RNA degradation_Homo sapiens_hsa030181.79860749
20Spliceosome_Homo sapiens_hsa030401.77939924
21Basal transcription factors_Homo sapiens_hsa030221.72860729
22Asthma_Homo sapiens_hsa053101.65236084
23Huntingtons disease_Homo sapiens_hsa050161.65204118
24Type I diabetes mellitus_Homo sapiens_hsa049401.63508282
25RNA transport_Homo sapiens_hsa030131.59438429
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.56622118
27Autoimmune thyroid disease_Homo sapiens_hsa053201.55279693
28Graft-versus-host disease_Homo sapiens_hsa053321.52373862
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.45958658
30Base excision repair_Homo sapiens_hsa034101.45468673
31Fanconi anemia pathway_Homo sapiens_hsa034601.39667571
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.37399195
33Alzheimers disease_Homo sapiens_hsa050101.31893410
34Pyrimidine metabolism_Homo sapiens_hsa002401.30661041
35Sulfur relay system_Homo sapiens_hsa041221.30236060
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.29546987
37Linoleic acid metabolism_Homo sapiens_hsa005911.29223128
38Purine metabolism_Homo sapiens_hsa002301.26371250
39Butanoate metabolism_Homo sapiens_hsa006501.24351272
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.21025812
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.18581894
42Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.12807444
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.12103239
44Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.09778691
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.05095602
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.93801609
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.91406883
48Antigen processing and presentation_Homo sapiens_hsa046120.86837496
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86493791
50Pyruvate metabolism_Homo sapiens_hsa006200.86450699
51Ether lipid metabolism_Homo sapiens_hsa005650.86169957
52Nitrogen metabolism_Homo sapiens_hsa009100.82891681
53Folate biosynthesis_Homo sapiens_hsa007900.80673617
54Rheumatoid arthritis_Homo sapiens_hsa053230.79557206
55Regulation of autophagy_Homo sapiens_hsa041400.78700255
56Sulfur metabolism_Homo sapiens_hsa009200.77192873
57Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.75887797
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75737998
59Tryptophan metabolism_Homo sapiens_hsa003800.75664098
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.73067289
61Cardiac muscle contraction_Homo sapiens_hsa042600.69468388
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65020275
63Peroxisome_Homo sapiens_hsa041460.64272657
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63017056
65Olfactory transduction_Homo sapiens_hsa047400.60965601
66Metabolic pathways_Homo sapiens_hsa011000.60878070
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57856206
68Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56447612
69Caffeine metabolism_Homo sapiens_hsa002320.53673322
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52958083
71Arachidonic acid metabolism_Homo sapiens_hsa005900.52511995
72Systemic lupus erythematosus_Homo sapiens_hsa053220.52464525
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49835409
74Steroid biosynthesis_Homo sapiens_hsa001000.48743076
75Selenocompound metabolism_Homo sapiens_hsa004500.48238872
76Chemical carcinogenesis_Homo sapiens_hsa052040.47020435
77Glutathione metabolism_Homo sapiens_hsa004800.46621989
78Vitamin digestion and absorption_Homo sapiens_hsa049770.46225655
79Hematopoietic cell lineage_Homo sapiens_hsa046400.46171193
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45985117
81beta-Alanine metabolism_Homo sapiens_hsa004100.44235105
82Retinol metabolism_Homo sapiens_hsa008300.42749184
83Fatty acid elongation_Homo sapiens_hsa000620.42279062
84Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.40520715
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40108062
86mRNA surveillance pathway_Homo sapiens_hsa030150.38374300
87Epstein-Barr virus infection_Homo sapiens_hsa051690.38134437
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34332038
89Vitamin B6 metabolism_Homo sapiens_hsa007500.33756597
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32821114
91T cell receptor signaling pathway_Homo sapiens_hsa046600.32245152
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.31807609
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.31595116
94Maturity onset diabetes of the young_Homo sapiens_hsa049500.31542648
95Carbon metabolism_Homo sapiens_hsa012000.29003438
96Fat digestion and absorption_Homo sapiens_hsa049750.27811834
97Cyanoamino acid metabolism_Homo sapiens_hsa004600.22556174
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.22288639
99Collecting duct acid secretion_Homo sapiens_hsa049660.20440995
100N-Glycan biosynthesis_Homo sapiens_hsa005100.19646171

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