HNRNPA1P41

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)4.99082685
2establishment of protein localization to mitochondrial membrane (GO:0090151)4.90567024
3proteasome assembly (GO:0043248)4.82014279
4DNA deamination (GO:0045006)4.65360126
5cullin deneddylation (GO:0010388)4.05346000
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.02883289
7epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.96491975
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.91624529
9energy coupled proton transport, down electrochemical gradient (GO:0015985)3.82912086
10ATP synthesis coupled proton transport (GO:0015986)3.82912086
11L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.81829568
12positive regulation of amino acid transport (GO:0051957)3.79533846
13water-soluble vitamin biosynthetic process (GO:0042364)3.73221373
14DNA replication checkpoint (GO:0000076)3.71536894
15protein deneddylation (GO:0000338)3.66509901
16ribosomal small subunit assembly (GO:0000028)3.61632760
17GPI anchor biosynthetic process (GO:0006506)3.55603822
18GPI anchor metabolic process (GO:0006505)3.53218420
19rRNA modification (GO:0000154)3.45958376
20amino acid salvage (GO:0043102)3.45793753
21L-methionine salvage (GO:0071267)3.45793753
22L-methionine biosynthetic process (GO:0071265)3.45793753
23base-excision repair, AP site formation (GO:0006285)3.45355803
24exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.44338018
25regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.44250482
26regulation of mitotic spindle checkpoint (GO:1903504)3.44250482
27cellular ketone body metabolic process (GO:0046950)3.43913769
28protein complex biogenesis (GO:0070271)3.43183762
29mitochondrial respiratory chain complex I assembly (GO:0032981)3.41332322
30NADH dehydrogenase complex assembly (GO:0010257)3.41332322
31mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.41332322
32termination of RNA polymerase III transcription (GO:0006386)3.39310493
33transcription elongation from RNA polymerase III promoter (GO:0006385)3.39310493
34mitochondrial respiratory chain complex assembly (GO:0033108)3.35565779
35nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.35557011
36negative regulation of amino acid transport (GO:0051956)3.34717083
37positive regulation of prostaglandin secretion (GO:0032308)3.30581037
38mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.29029459
39DNA double-strand break processing (GO:0000729)3.22591429
40ribosome assembly (GO:0042255)3.19844249
41branched-chain amino acid catabolic process (GO:0009083)3.18669830
42serotonin receptor signaling pathway (GO:0007210)3.17635755
43rRNA methylation (GO:0031167)3.11184823
44preassembly of GPI anchor in ER membrane (GO:0016254)3.08266597
45cytidine deamination (GO:0009972)3.07779491
46cytidine metabolic process (GO:0046087)3.07779491
47cytidine catabolic process (GO:0006216)3.07779491
48ketone body metabolic process (GO:1902224)3.04772926
49negative regulation of transcription regulatory region DNA binding (GO:2000678)3.04653897
50positive regulation of catecholamine secretion (GO:0033605)3.00682451
51chromatin remodeling at centromere (GO:0031055)3.00380410
52positive regulation of organic acid transport (GO:0032892)2.92566294
53sequestering of actin monomers (GO:0042989)2.89496604
54regulation of glutamate secretion (GO:0014048)2.86947440
55response to pheromone (GO:0019236)2.86241366
56intracellular protein transmembrane import (GO:0044743)2.86002479
57kinetochore organization (GO:0051383)2.85946592
58aggressive behavior (GO:0002118)2.84089014
59kinetochore assembly (GO:0051382)2.83875094
60methionine biosynthetic process (GO:0009086)2.83675167
61pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.82671628
62negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.82083953
63pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.82056373
64kynurenine metabolic process (GO:0070189)2.79790826
65indolalkylamine metabolic process (GO:0006586)2.78729046
66chaperone-mediated protein transport (GO:0072321)2.78527878
67CENP-A containing nucleosome assembly (GO:0034080)2.76020818
68protein-cofactor linkage (GO:0018065)2.73076943
69respiratory chain complex IV assembly (GO:0008535)2.70993872
70RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.70194346
71iron-sulfur cluster assembly (GO:0016226)2.70030149
72metallo-sulfur cluster assembly (GO:0031163)2.70030149
73IMP biosynthetic process (GO:0006188)2.68478150
74electron transport chain (GO:0022900)2.68238688
75respiratory electron transport chain (GO:0022904)2.66460066
76positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.65891033
77DNA catabolic process, exonucleolytic (GO:0000738)2.64029337
78regulation of chronic inflammatory response (GO:0002676)2.63849167
79tRNA processing (GO:0008033)2.63740342
80purine nucleobase biosynthetic process (GO:0009113)2.62787475
81RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.60722216
82tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.60722216
83regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.59921223
84resolution of meiotic recombination intermediates (GO:0000712)2.58967908
85regulation of prostaglandin secretion (GO:0032306)2.57770789
86synapsis (GO:0007129)2.57450398
87cellular response to nicotine (GO:0071316)2.56094486
88DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.54933919
89signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.54512701
90signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.54512701
91signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.54512701
92aspartate family amino acid biosynthetic process (GO:0009067)2.54354822
93regulation of cellular amino acid metabolic process (GO:0006521)2.53402834
94nucleobase biosynthetic process (GO:0046112)2.53363569
95C-terminal protein lipidation (GO:0006501)2.52908065
96pharyngeal system development (GO:0060037)2.51003126
97platelet dense granule organization (GO:0060155)2.50966542
98piRNA metabolic process (GO:0034587)2.50885126
99male meiosis (GO:0007140)2.48626214
100ribosomal large subunit biogenesis (GO:0042273)2.48239622

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.28710503
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.81656394
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.44815753
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.36853595
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.24545088
6VDR_22108803_ChIP-Seq_LS180_Human3.01807950
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.88806501
8ZNF274_21170338_ChIP-Seq_K562_Hela2.72990986
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.70588419
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.64420525
11VDR_23849224_ChIP-Seq_CD4+_Human2.58323563
12EWS_26573619_Chip-Seq_HEK293_Human2.50636462
13FUS_26573619_Chip-Seq_HEK293_Human2.36052849
14IGF1R_20145208_ChIP-Seq_DFB_Human2.33981584
15ELK1_19687146_ChIP-ChIP_HELA_Human2.26091177
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.16011170
17FOXP3_21729870_ChIP-Seq_TREG_Human2.15318883
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.11245121
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.09238424
20PCGF2_27294783_Chip-Seq_ESCs_Mouse2.03350565
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.01153419
22MYC_18940864_ChIP-ChIP_HL60_Human1.98873062
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.98802247
24POU3F2_20337985_ChIP-ChIP_501MEL_Human1.97759802
25NOTCH1_21737748_ChIP-Seq_TLL_Human1.97372184
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.91053479
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.89419495
28ELF1_17652178_ChIP-ChIP_JURKAT_Human1.84483902
29MYC_18555785_ChIP-Seq_MESCs_Mouse1.68526064
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.62254265
31POU5F1_16153702_ChIP-ChIP_HESCs_Human1.60132195
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.58866713
33TAF15_26573619_Chip-Seq_HEK293_Human1.56567205
34P300_19829295_ChIP-Seq_ESCs_Human1.56359105
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54540519
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53544714
37MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.52870407
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.50203285
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.50183885
40PCGF2_27294783_Chip-Seq_NPCs_Mouse1.47692669
41PADI4_21655091_ChIP-ChIP_MCF-7_Human1.45960281
42SALL1_21062744_ChIP-ChIP_HESCs_Human1.45632931
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.44731321
44ER_23166858_ChIP-Seq_MCF-7_Human1.43172136
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40940151
46TP53_22573176_ChIP-Seq_HFKS_Human1.40677839
47HTT_18923047_ChIP-ChIP_STHdh_Human1.38797935
48TTF2_22483619_ChIP-Seq_HELA_Human1.37574274
49EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.36491800
50PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.36248047
51IRF1_19129219_ChIP-ChIP_H3396_Human1.28361159
52DCP1A_22483619_ChIP-Seq_HELA_Human1.25288952
53EZH2_27294783_Chip-Seq_NPCs_Mouse1.23893470
54NCOR_22424771_ChIP-Seq_293T_Human1.20344080
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19514367
56SOX2_19829295_ChIP-Seq_ESCs_Human1.19125395
57NANOG_19829295_ChIP-Seq_ESCs_Human1.19125395
58FOXA1_21572438_ChIP-Seq_LNCaP_Human1.18939252
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.17866832
60CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.17337604
61SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15229120
62FOXA1_25329375_ChIP-Seq_VCAP_Human1.15046723
63FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15046723
64AUTS2_25519132_ChIP-Seq_293T-REX_Human1.14943574
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13741643
66RNF2_27304074_Chip-Seq_NSC_Mouse1.11246230
67GATA3_26560356_Chip-Seq_TH2_Human1.10977913
68MYC_18358816_ChIP-ChIP_MESCs_Mouse1.07459820
69POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03204879
70MYC_19030024_ChIP-ChIP_MESCs_Mouse1.02564580
71EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.02195542
72BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01107503
73TCF4_22108803_ChIP-Seq_LS180_Human1.00796852
74AR_20517297_ChIP-Seq_VCAP_Human1.00416797
75GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99936823
76IRF8_21731497_ChIP-ChIP_J774_Mouse0.99565338
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99272569
78CBP_20019798_ChIP-Seq_JUKART_Human0.99272569
79RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.97938883
80HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.97803892
81FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.97784408
82KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97623327
83FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97330662
84ELK1_22589737_ChIP-Seq_MCF10A_Human0.97067036
85BCAT_22108803_ChIP-Seq_LS180_Human0.96489272
86TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95888889
87E2F1_18555785_ChIP-Seq_MESCs_Mouse0.94336324
88CRX_20693478_ChIP-Seq_RETINA_Mouse0.93281301
89EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93212463
90SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.92615473
91MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.91815279
92LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.91421732
93P53_22387025_ChIP-Seq_ESCs_Mouse0.91405461
94MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91288075
95CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.90970859
96STAT3_18555785_Chip-Seq_ESCs_Mouse0.90349998
97IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.89912541
98GABP_19822575_ChIP-Seq_HepG2_Human0.89908618
99E2F7_22180533_ChIP-Seq_HELA_Human0.87512595
100NANOG_16153702_ChIP-ChIP_HESCs_Human0.87164774

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006072_abnormal_retinal_apoptosis3.96572794
2MP0006292_abnormal_olfactory_placode3.23486892
3MP0002822_catalepsy3.09169332
4MP0005084_abnormal_gallbladder_morpholo2.94748440
5MP0002234_abnormal_pharynx_morphology2.89170914
6MP0003195_calcinosis2.76609681
7MP0002102_abnormal_ear_morphology2.65776110
8MP0002163_abnormal_gland_morphology2.53579947
9MP0008961_abnormal_basal_metabolism2.34900075
10MP0005671_abnormal_response_to2.29281007
11MP0000372_irregular_coat_pigmentation2.28548904
12MP0008058_abnormal_DNA_repair2.23428398
13MP0008877_abnormal_DNA_methylation2.12440246
14MP0005253_abnormal_eye_physiology2.01306369
15MP0010094_abnormal_chromosome_stability2.00398938
16MP0005646_abnormal_pituitary_gland1.84361213
17MP0005551_abnormal_eye_electrophysiolog1.83878752
18MP0003011_delayed_dark_adaptation1.78786826
19MP0004145_abnormal_muscle_electrophysio1.74681421
20MP0003806_abnormal_nucleotide_metabolis1.69938050
21MP0001293_anophthalmia1.66965056
22MP0008995_early_reproductive_senescence1.66402227
23MP0008872_abnormal_physiological_respon1.64414232
24MP0009379_abnormal_foot_pigmentation1.63903611
25MP0000049_abnormal_middle_ear1.56946281
26MP0003880_abnormal_central_pattern1.56828633
27MP0003786_premature_aging1.55076229
28MP0000631_abnormal_neuroendocrine_gland1.50805202
29MP0001764_abnormal_homeostasis1.43036075
30MP0004957_abnormal_blastocyst_morpholog1.42395034
31MP0008875_abnormal_xenobiotic_pharmacok1.40714821
32MP0002938_white_spotting1.39850987
33MP0005645_abnormal_hypothalamus_physiol1.39413160
34MP0005379_endocrine/exocrine_gland_phen1.39097123
35MP0003693_abnormal_embryo_hatching1.36891716
36MP0005075_abnormal_melanosome_morpholog1.36591532
37MP0004147_increased_porphyrin_level1.31798527
38MP0004142_abnormal_muscle_tone1.29713865
39MP0001919_abnormal_reproductive_system1.16862970
40MP0003252_abnormal_bile_duct1.15915008
41MP0003937_abnormal_limbs/digits/tail_de1.15839294
42MP0001879_abnormal_lymphatic_vessel1.14938615
43MP0000685_abnormal_immune_system1.14230410
44MP0008789_abnormal_olfactory_epithelium1.13634548
45MP0005085_abnormal_gallbladder_physiolo1.12815279
46MP0003283_abnormal_digestive_organ1.12242763
47MP0005389_reproductive_system_phenotype1.10663607
48MP0004215_abnormal_myocardial_fiber1.10210255
49MP0002009_preneoplasia1.09278276
50MP0000566_synostosis1.07024763
51MP0004043_abnormal_pH_regulation1.06925446
52MP0002736_abnormal_nociception_after1.06696293
53MP0001968_abnormal_touch/_nociception1.06523091
54MP0003718_maternal_effect1.03680975
55MP0005167_abnormal_blood-brain_barrier1.03244426
56MP0002928_abnormal_bile_duct1.01911696
57MP0006036_abnormal_mitochondrial_physio0.99813736
58MP0001986_abnormal_taste_sensitivity0.99723806
59MP0001984_abnormal_olfaction0.96840859
60MP0003787_abnormal_imprinting0.96433025
61MP0009745_abnormal_behavioral_response0.95950186
62MP0009250_abnormal_appendicular_skeleto0.95546731
63MP0002095_abnormal_skin_pigmentation0.95411003
64MP0008932_abnormal_embryonic_tissue0.95222440
65MP0009785_altered_susceptibility_to0.93310647
66MP0003119_abnormal_digestive_system0.93154813
67MP0005391_vision/eye_phenotype0.92411635
68MP0004782_abnormal_surfactant_physiolog0.91112568
69MP0010368_abnormal_lymphatic_system0.90726141
70MP0001188_hyperpigmentation0.89579318
71MP0002090_abnormal_vision0.89497381
72MP0002396_abnormal_hematopoietic_system0.88635365
73MP0003878_abnormal_ear_physiology0.88404965
74MP0005377_hearing/vestibular/ear_phenot0.88404965
75MP0002272_abnormal_nervous_system0.87128528
76MP0005410_abnormal_fertilization0.86805809
77MP0001800_abnormal_humoral_immune0.83009006
78MP0004885_abnormal_endolymph0.82767676
79MP0003567_abnormal_fetal_cardiomyocyte0.81323329
80MP0000383_abnormal_hair_follicle0.80867723
81MP0005195_abnormal_posterior_eye0.79643723
82MP0001529_abnormal_vocalization0.79510996
83MP0001929_abnormal_gametogenesis0.78106359
84MP0003122_maternal_imprinting0.77458795
85MP0002735_abnormal_chemical_nociception0.76035404
86MP0001963_abnormal_hearing_physiology0.75947047
87MP0000613_abnormal_salivary_gland0.73856466
88MP0001119_abnormal_female_reproductive0.73476495
89MP0000689_abnormal_spleen_morphology0.67903766
90MP0003646_muscle_fatigue0.67658555
91MP0003121_genomic_imprinting0.67306619
92MP0009697_abnormal_copulation0.67220270
93MP0002160_abnormal_reproductive_system0.67129946
94MP0002638_abnormal_pupillary_reflex0.65735618
95MP0002210_abnormal_sex_determination0.65699651
96MP0006276_abnormal_autonomic_nervous0.65421642
97MP0005310_abnormal_salivary_gland0.65252693
98MP0002405_respiratory_system_inflammati0.65117165
99MP0002233_abnormal_nose_morphology0.64974231
100MP0000427_abnormal_hair_cycle0.64605123

Predicted human phenotypes

RankGene SetZ-score
1Increased hepatocellular lipid droplets (HP:0006565)3.96065028
2Abnormality of the renal collecting system (HP:0004742)3.90300600
3Mitochondrial inheritance (HP:0001427)3.68341255
4Acute necrotizing encephalopathy (HP:0006965)3.53275907
5Lipid accumulation in hepatocytes (HP:0006561)3.48675998
6Increased CSF lactate (HP:0002490)3.33142204
7Methylmalonic acidemia (HP:0002912)3.28463039
8Cerebral edema (HP:0002181)3.20457520
9Abnormal mitochondria in muscle tissue (HP:0008316)3.14614180
10Hepatocellular necrosis (HP:0001404)3.11179410
11Congenital stationary night blindness (HP:0007642)3.10470498
12Duplicated collecting system (HP:0000081)3.04135540
13Acute encephalopathy (HP:0006846)2.97939244
14Hepatic necrosis (HP:0002605)2.95045458
15Absent rod-and cone-mediated responses on ERG (HP:0007688)2.91431188
16Concave nail (HP:0001598)2.90995925
17Progressive macrocephaly (HP:0004481)2.90675073
183-Methylglutaconic aciduria (HP:0003535)2.89535634
19Pancreatic cysts (HP:0001737)2.87197121
20Stenosis of the external auditory canal (HP:0000402)2.81800287
21True hermaphroditism (HP:0010459)2.78470812
22Hyperglycinemia (HP:0002154)2.77937754
23Abolished electroretinogram (ERG) (HP:0000550)2.77569307
24Molar tooth sign on MRI (HP:0002419)2.71859181
25Abnormality of midbrain morphology (HP:0002418)2.71859181
26Optic disc pallor (HP:0000543)2.67408271
27Pancreatic fibrosis (HP:0100732)2.66691613
28Nephronophthisis (HP:0000090)2.65388194
29Congenital, generalized hypertrichosis (HP:0004540)2.64130028
30Severe combined immunodeficiency (HP:0004430)2.60685821
31Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.56890398
32Short 1st metacarpal (HP:0010034)2.56890398
33Colon cancer (HP:0003003)2.50396641
34Exertional dyspnea (HP:0002875)2.48866948
35Abnormal rod and cone electroretinograms (HP:0008323)2.47005893
36Methylmalonic aciduria (HP:0012120)2.45876804
37Renal Fanconi syndrome (HP:0001994)2.45618155
38Increased serum lactate (HP:0002151)2.41608961
39Type II lissencephaly (HP:0007260)2.34994347
40Medial flaring of the eyebrow (HP:0010747)2.34964382
41IgG deficiency (HP:0004315)2.32349984
42Lethargy (HP:0001254)2.30254898
43Abnormality of the 1st metacarpal (HP:0010009)2.29837381
44Abnormality of serum amino acid levels (HP:0003112)2.27437332
45Lactic acidosis (HP:0003128)2.27136964
46Increased intramyocellular lipid droplets (HP:0012240)2.23897238
47Ketosis (HP:0001946)2.23759588
48Abnormality of the labia minora (HP:0012880)2.19128880
49Attenuation of retinal blood vessels (HP:0007843)2.18227328
50Abnormality of the vitamin B12 metabolism (HP:0004341)2.14652539
51Abnormality of the renal medulla (HP:0100957)2.05470664
52Aplastic anemia (HP:0001915)2.05255066
53Adactyly (HP:0009776)2.05230327
54Abnormality of vitamin B metabolism (HP:0004340)2.04880150
55Type I transferrin isoform profile (HP:0003642)2.04513534
56Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.04493506
57Abnormality of the renal cortex (HP:0011035)2.03599029
58Decreased central vision (HP:0007663)2.01818333
59Hypoproteinemia (HP:0003075)2.00882380
60Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.00760581
61Abnormal protein N-linked glycosylation (HP:0012347)2.00760581
62Abnormal protein glycosylation (HP:0012346)2.00760581
63Abnormal glycosylation (HP:0012345)2.00760581
64Decreased electroretinogram (ERG) amplitude (HP:0000654)2.00164176
65Respiratory failure (HP:0002878)1.99608474
66Pendular nystagmus (HP:0012043)1.96497739
67Constricted visual fields (HP:0001133)1.96153335
68Abnormal drinking behavior (HP:0030082)1.91841211
69Polydipsia (HP:0001959)1.91841211
70Thyroiditis (HP:0100646)1.91616879
71Combined immunodeficiency (HP:0005387)1.91562472
72Type 2 muscle fiber atrophy (HP:0003554)1.91214174
73Renal cortical cysts (HP:0000803)1.90291956
74Abnormality of aspartate family amino acid metabolism (HP:0010899)1.88876593
75Abnormality of serine family amino acid metabolism (HP:0010894)1.87754202
76Abnormality of glycine metabolism (HP:0010895)1.87754202
77Parakeratosis (HP:0001036)1.86334586
78Aplasia/hypoplasia of the uterus (HP:0008684)1.84607131
79Sclerocornea (HP:0000647)1.83580387
80Glycosuria (HP:0003076)1.81569717
81Abnormality of urine glucose concentration (HP:0011016)1.81569717
82Pancytopenia (HP:0001876)1.80309983
83Hypomagnesemia (HP:0002917)1.79893884
84Cerebellar dysplasia (HP:0007033)1.79832492
85CNS demyelination (HP:0007305)1.77209831
86Reticulocytopenia (HP:0001896)1.76938042
87Abnormality of the anterior horn cell (HP:0006802)1.76409326
88Degeneration of anterior horn cells (HP:0002398)1.76409326
89Microvesicular hepatic steatosis (HP:0001414)1.75902415
90Meckel diverticulum (HP:0002245)1.75459315
91Large for gestational age (HP:0001520)1.75417458
92Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.74908357
93Dicarboxylic aciduria (HP:0003215)1.74266725
94Abnormality of dicarboxylic acid metabolism (HP:0010995)1.74266725
95Hyperglycinuria (HP:0003108)1.73875884
96Aplasia/Hypoplasia involving the musculature (HP:0001460)1.72048255
97Oligodactyly (hands) (HP:0001180)1.71028097
98Abnormality of the prostate (HP:0008775)1.70585733
99Hypoplasia of the uterus (HP:0000013)1.70326744
100Abnormality of methionine metabolism (HP:0010901)1.69881481

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.19096499
2EIF2AK33.94676922
3TESK23.50517296
4TXK2.82051152
5VRK22.73996858
6ZAK2.67390342
7TIE12.66426469
8BUB12.48197136
9NUAK12.47477303
10MST42.33827659
11GRK12.15144941
12ADRBK21.81609955
13MAP4K21.79481794
14PASK1.74442806
15VRK11.67856605
16EIF2AK21.60401552
17MUSK1.57328029
18EIF2AK11.53193175
19TLK11.53071620
20TEC1.48882679
21TRIM281.44458115
22PLK41.38216760
23PLK31.33223361
24NEK11.31198013
25MKNK11.29820013
26WNK31.28355957
27ERBB31.28171464
28MAP3K121.26417878
29TAOK31.21851369
30TSSK61.17740670
31STK391.13805706
32DYRK21.10539446
33FRK1.09924682
34BCR1.07629315
35TAF11.06512208
36WNK41.03588753
37BRSK20.97584825
38WEE10.97144346
39STK38L0.96064110
40CDC70.95966856
41PBK0.94267678
42MAP3K40.92326662
43MAPK130.90974953
44SRPK10.90460499
45BMPR1B0.90132413
46TNIK0.87284897
47OXSR10.84359923
48LIMK10.78939805
49ITK0.77395896
50KDR0.75516340
51RPS6KA40.74410329
52ATR0.73394791
53STK30.69004497
54MAP2K70.68495343
55MKNK20.65603463
56PLK10.64157536
57TGFBR10.62907650
58ACVR1B0.62538063
59CAMKK20.61691552
60KIT0.61526179
61INSRR0.59029341
62CSNK1G30.58876778
63EPHA40.57589443
64PRKCQ0.57557932
65STK240.57114132
66STK160.56688672
67PINK10.56512430
68CSNK1A1L0.55512370
69CSNK1G10.54339419
70NLK0.54242249
71GRK60.54191185
72NME10.54059962
73IKBKB0.52780886
74TTK0.50895930
75PLK20.46951962
76AURKB0.44782423
77PRKCE0.42175375
78PIM10.39948522
79MATK0.39281674
80DYRK30.38461999
81ADRBK10.37785587
82MAP2K20.37465710
83CSNK1G20.37445518
84DAPK10.37207046
85CSNK2A10.37190858
86CDK30.36529942
87PRKCG0.36371687
88FGFR10.36256089
89OBSCN0.32774227
90IGF1R0.32651997
91BRSK10.30858933
92MAPK150.30043502
93MAPKAPK30.29546505
94FLT30.28311777
95RPS6KA50.27794539
96CHEK20.26356102
97STK40.26288004
98LYN0.25477628
99LCK0.25145804
100CDK80.25108479

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.45884850
2Proteasome_Homo sapiens_hsa030503.36619874
3Oxidative phosphorylation_Homo sapiens_hsa001902.98383083
4Protein export_Homo sapiens_hsa030602.98341115
5Propanoate metabolism_Homo sapiens_hsa006402.73808602
6RNA polymerase_Homo sapiens_hsa030202.57356698
7Ribosome_Homo sapiens_hsa030102.52829775
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.51023984
9Parkinsons disease_Homo sapiens_hsa050122.37096621
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.25401894
11One carbon pool by folate_Homo sapiens_hsa006701.97559349
12Primary immunodeficiency_Homo sapiens_hsa053401.91267852
13Phototransduction_Homo sapiens_hsa047441.84494142
14Mismatch repair_Homo sapiens_hsa034301.84083411
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.78949777
16Homologous recombination_Homo sapiens_hsa034401.70299943
17Fanconi anemia pathway_Homo sapiens_hsa034601.68711843
18Butanoate metabolism_Homo sapiens_hsa006501.68567012
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.66929284
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.66431505
21RNA degradation_Homo sapiens_hsa030181.66337307
22Basal transcription factors_Homo sapiens_hsa030221.59137107
23DNA replication_Homo sapiens_hsa030301.57826950
24Huntingtons disease_Homo sapiens_hsa050161.55997337
25Pyrimidine metabolism_Homo sapiens_hsa002401.53623329
26Nucleotide excision repair_Homo sapiens_hsa034201.49367143
27Tryptophan metabolism_Homo sapiens_hsa003801.45744853
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.41426070
29Caffeine metabolism_Homo sapiens_hsa002321.41239421
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.40856925
31Purine metabolism_Homo sapiens_hsa002301.40826109
32Alzheimers disease_Homo sapiens_hsa050101.37334238
33Spliceosome_Homo sapiens_hsa030401.34795899
34Sulfur relay system_Homo sapiens_hsa041221.34549195
35Base excision repair_Homo sapiens_hsa034101.27009485
36Non-homologous end-joining_Homo sapiens_hsa034501.22951424
37Selenocompound metabolism_Homo sapiens_hsa004501.22497320
38RNA transport_Homo sapiens_hsa030131.22039356
39Nitrogen metabolism_Homo sapiens_hsa009101.20046770
40Maturity onset diabetes of the young_Homo sapiens_hsa049501.18173355
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.16397852
42Peroxisome_Homo sapiens_hsa041461.16381680
43Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.16200533
44Intestinal immune network for IgA production_Homo sapiens_hsa046721.12843569
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.07612847
46Asthma_Homo sapiens_hsa053101.06729894
47Steroid biosynthesis_Homo sapiens_hsa001000.98142553
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97574488
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.92607744
50Linoleic acid metabolism_Homo sapiens_hsa005910.91798820
51Autoimmune thyroid disease_Homo sapiens_hsa053200.89582823
52Folate biosynthesis_Homo sapiens_hsa007900.88265057
53Fatty acid elongation_Homo sapiens_hsa000620.87894884
54Allograft rejection_Homo sapiens_hsa053300.81166107
55Collecting duct acid secretion_Homo sapiens_hsa049660.77056506
56Metabolic pathways_Homo sapiens_hsa011000.75929362
57Type I diabetes mellitus_Homo sapiens_hsa049400.75300402
58Cardiac muscle contraction_Homo sapiens_hsa042600.75176429
59Rheumatoid arthritis_Homo sapiens_hsa053230.74116937
60Retinol metabolism_Homo sapiens_hsa008300.72916827
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65736718
62Primary bile acid biosynthesis_Homo sapiens_hsa001200.65577537
63Sulfur metabolism_Homo sapiens_hsa009200.64878164
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64379230
65Olfactory transduction_Homo sapiens_hsa047400.63588944
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63407600
67alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62364672
68Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61659100
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61239535
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57472364
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.57354682
72Regulation of autophagy_Homo sapiens_hsa041400.52459793
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50789231
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47823428
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47583792
76Graft-versus-host disease_Homo sapiens_hsa053320.47370761
77Antigen processing and presentation_Homo sapiens_hsa046120.46408305
78Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.45612370
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.44453811
80Vitamin B6 metabolism_Homo sapiens_hsa007500.42830167
81Arachidonic acid metabolism_Homo sapiens_hsa005900.42821759
82beta-Alanine metabolism_Homo sapiens_hsa004100.41630673
83Fatty acid degradation_Homo sapiens_hsa000710.40761990
84Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.40496860
85Hematopoietic cell lineage_Homo sapiens_hsa046400.39742295
86Chemical carcinogenesis_Homo sapiens_hsa052040.39146721
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38228274
88Fat digestion and absorption_Homo sapiens_hsa049750.38163535
89Pyruvate metabolism_Homo sapiens_hsa006200.37656130
90Cell cycle_Homo sapiens_hsa041100.37126436
91Carbon metabolism_Homo sapiens_hsa012000.36912892
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36601999
93Glutathione metabolism_Homo sapiens_hsa004800.36237128
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.36047035
95Salivary secretion_Homo sapiens_hsa049700.35503722
96ABC transporters_Homo sapiens_hsa020100.35503366
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33912949
98NF-kappa B signaling pathway_Homo sapiens_hsa040640.32489316
99Ether lipid metabolism_Homo sapiens_hsa005650.31309993
100mRNA surveillance pathway_Homo sapiens_hsa030150.27823823

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