HNRNPA1P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.49548068
2sequestering of actin monomers (GO:0042989)5.11995121
3regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.67389009
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.65746828
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.36040752
6ATP synthesis coupled proton transport (GO:0015986)4.36040752
7platelet dense granule organization (GO:0060155)4.23586407
8ribosomal small subunit assembly (GO:0000028)4.18949171
9cytidine deamination (GO:0009972)3.94769931
10cytidine metabolic process (GO:0046087)3.94769931
11cytidine catabolic process (GO:0006216)3.94769931
12tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.74575922
13RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.74575922
14mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.71249026
15establishment of protein localization to mitochondrial membrane (GO:0090151)3.67487347
16protein neddylation (GO:0045116)3.63965191
17cellular response to interleukin-15 (GO:0071350)3.62145368
18behavioral response to nicotine (GO:0035095)3.54733437
19respiratory electron transport chain (GO:0022904)3.48671476
20mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.47207676
21mitochondrial respiratory chain complex I assembly (GO:0032981)3.47207676
22NADH dehydrogenase complex assembly (GO:0010257)3.47207676
23electron transport chain (GO:0022900)3.45706633
24protein complex biogenesis (GO:0070271)3.44173203
25base-excision repair, AP site formation (GO:0006285)3.39655336
26mitochondrial respiratory chain complex assembly (GO:0033108)3.33735834
27pyrimidine ribonucleoside catabolic process (GO:0046133)3.24834129
28proteasome assembly (GO:0043248)3.20600485
29regulation of chronic inflammatory response (GO:0002676)3.19649351
30regulation of female receptivity (GO:0045924)3.15787977
31regulation of T cell receptor signaling pathway (GO:0050856)3.12439719
32negative regulation of T cell receptor signaling pathway (GO:0050860)3.11303001
33nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.10125594
34water-soluble vitamin biosynthetic process (GO:0042364)3.09695025
35termination of RNA polymerase III transcription (GO:0006386)3.07810355
36transcription elongation from RNA polymerase III promoter (GO:0006385)3.07810355
37DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.06146363
38negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.05525504
39signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.03267775
40signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.03267775
41signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.03267775
42negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.01403760
43regulation of cellular amino acid metabolic process (GO:0006521)2.98961360
44respiratory chain complex IV assembly (GO:0008535)2.96585108
45positive regulation of prostaglandin secretion (GO:0032308)2.96319204
46mast cell activation (GO:0045576)2.95071535
47signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.94866292
48intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.94866292
49negative regulation by host of viral transcription (GO:0043922)2.87388385
50signal transduction involved in DNA integrity checkpoint (GO:0072401)2.87121836
51signal transduction involved in DNA damage checkpoint (GO:0072422)2.87121836
52signal transduction involved in cell cycle checkpoint (GO:0072395)2.85382541
53mast cell activation involved in immune response (GO:0002279)2.81917441
54mast cell degranulation (GO:0043303)2.81917441
55positive regulation of T cell mediated cytotoxicity (GO:0001916)2.80823761
56response to interleukin-15 (GO:0070672)2.80558878
57L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.78731372
58exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.77749269
59viral transcription (GO:0019083)2.75206383
60translational termination (GO:0006415)2.74079283
61regulation of T cell mediated cytotoxicity (GO:0001914)2.73770606
62negative regulation of T cell apoptotic process (GO:0070233)2.73768108
63positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.73365339
64purine deoxyribonucleotide catabolic process (GO:0009155)2.72899258
65regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.72392568
66inner mitochondrial membrane organization (GO:0007007)2.72303641
67positive regulation of defense response to virus by host (GO:0002230)2.72288623
68regulation of B cell receptor signaling pathway (GO:0050855)2.72157773
69female mating behavior (GO:0060180)2.71972196
70positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.69333365
71S-adenosylmethionine metabolic process (GO:0046500)2.69019842
72cytochrome complex assembly (GO:0017004)2.68778402
73iron-sulfur cluster assembly (GO:0016226)2.66567817
74metallo-sulfur cluster assembly (GO:0031163)2.66567817
75kynurenine metabolic process (GO:0070189)2.66059532
76SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.65518236
77negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.64848158
78negative regulation of ligase activity (GO:0051352)2.64848158
79regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.64274064
80hydrogen ion transmembrane transport (GO:1902600)2.64084211
81purine nucleoside triphosphate biosynthetic process (GO:0009145)2.61872288
82cotranslational protein targeting to membrane (GO:0006613)2.61360700
83protein targeting to ER (GO:0045047)2.59696646
84proton transport (GO:0015992)2.59123383
85L-methionine salvage (GO:0071267)2.58649094
86L-methionine biosynthetic process (GO:0071265)2.58649094
87amino acid salvage (GO:0043102)2.58649094
88regulation of leukocyte mediated cytotoxicity (GO:0001910)2.57370365
89deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.56849737
90regulation of rhodopsin mediated signaling pathway (GO:0022400)2.56730660
91RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.56384316
92ribosomal large subunit biogenesis (GO:0042273)2.56107516
93fucose catabolic process (GO:0019317)2.56075813
94L-fucose metabolic process (GO:0042354)2.56075813
95L-fucose catabolic process (GO:0042355)2.56075813
96antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.55297007
97translational elongation (GO:0006414)2.54970777
98hydrogen transport (GO:0006818)2.54740718
99rRNA modification (GO:0000154)2.52992967
100ATP biosynthetic process (GO:0006754)2.52274173

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human3.89204180
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.68102397
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.36836022
4HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.89854828
5ZNF274_21170338_ChIP-Seq_K562_Hela2.84771039
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.74472648
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.71515964
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.58278724
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.57639069
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.56065308
11VDR_22108803_ChIP-Seq_LS180_Human2.53756916
12VDR_23849224_ChIP-Seq_CD4+_Human2.53068889
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.47424357
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.26726027
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.25454386
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.22356932
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.22129517
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.10293680
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.09874798
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.04552366
21FOXP3_21729870_ChIP-Seq_TREG_Human2.03369297
22ELK1_19687146_ChIP-ChIP_HELA_Human1.98572987
23SRF_21415370_ChIP-Seq_HL-1_Mouse1.84662682
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.83719587
25CREB1_15753290_ChIP-ChIP_HEK293T_Human1.83482901
26MYC_18940864_ChIP-ChIP_HL60_Human1.81253925
27IGF1R_20145208_ChIP-Seq_DFB_Human1.78766469
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.76443066
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74744141
30NOTCH1_21737748_ChIP-Seq_TLL_Human1.74173672
31FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.71310882
32IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.66540049
33EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.66253631
34TP53_22573176_ChIP-Seq_HFKS_Human1.63280750
35FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.60406311
36TAF15_26573619_Chip-Seq_HEK293_Human1.59827354
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.59082126
38GATA3_26560356_Chip-Seq_TH2_Human1.56899034
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56419238
40EGR1_23403033_ChIP-Seq_LIVER_Mouse1.54171082
41EWS_26573619_Chip-Seq_HEK293_Human1.53925718
42ER_23166858_ChIP-Seq_MCF-7_Human1.49443164
43AR_20517297_ChIP-Seq_VCAP_Human1.46838007
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43325689
45IRF8_21731497_ChIP-ChIP_J774_Mouse1.42383804
46FOXA1_27270436_Chip-Seq_PROSTATE_Human1.41603118
47FOXA1_25329375_ChIP-Seq_VCAP_Human1.41603118
48MYB_26560356_Chip-Seq_TH2_Human1.40141895
49FUS_26573619_Chip-Seq_HEK293_Human1.39674343
50MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.36790507
51EZH2_22144423_ChIP-Seq_EOC_Human1.35326856
52LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.33065773
53E2F4_17652178_ChIP-ChIP_JURKAT_Human1.30263381
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.29778887
55PCGF2_27294783_Chip-Seq_NPCs_Mouse1.27794531
56IRF8_22096565_ChIP-ChIP_GC-B_Human1.26554858
57P300_19829295_ChIP-Seq_ESCs_Human1.24750566
58PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.23448695
59PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.21684433
60SOX2_19829295_ChIP-Seq_ESCs_Human1.21195312
61NANOG_19829295_ChIP-Seq_ESCs_Human1.21195312
62PADI4_21655091_ChIP-ChIP_MCF-7_Human1.20861545
63NCOR_22424771_ChIP-Seq_293T_Human1.18586645
64FOXA1_21572438_ChIP-Seq_LNCaP_Human1.18018782
65NFE2_27457419_Chip-Seq_LIVER_Mouse1.15314349
66POU5F1_16153702_ChIP-ChIP_HESCs_Human1.14194247
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.13874595
68CBP_20019798_ChIP-Seq_JUKART_Human1.13874595
69MYC_18555785_ChIP-Seq_MESCs_Mouse1.12611243
70GATA3_21878914_ChIP-Seq_MCF-7_Human1.12476107
71HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12341254
72RUNX_20019798_ChIP-Seq_JUKART_Human1.12079391
73ZFP57_27257070_Chip-Seq_ESCs_Mouse1.11208860
74POU3F2_20337985_ChIP-ChIP_501MEL_Human1.11175850
75HTT_18923047_ChIP-ChIP_STHdh_Human1.08684984
76ELK1_22589737_ChIP-Seq_MCF10A_Human1.08648755
77POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07751448
78SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07295265
79SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.06724796
80IRF1_19129219_ChIP-ChIP_H3396_Human1.06369647
81ERG_20517297_ChIP-Seq_VCAP_Human1.05312290
82FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.03814978
83GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03325874
84MYC_18358816_ChIP-ChIP_MESCs_Mouse1.03144224
85CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.02723498
86TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.01842195
87AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99580685
88NANOG_20526341_ChIP-Seq_ESCs_Human0.99488202
89RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.99450005
90ETV2_25802403_ChIP-Seq_MESCs_Mouse0.98181316
91RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97904791
92TTF2_22483619_ChIP-Seq_HELA_Human0.97231011
93HOXB7_26014856_ChIP-Seq_BT474_Human0.96789513
94GATA3_27048872_Chip-Seq_THYMUS_Human0.94622659
95FOXH1_21741376_ChIP-Seq_EPCs_Human0.94142143
96TAF2_19829295_ChIP-Seq_ESCs_Human0.93090092
97CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.92765612
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91694961
99CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.91510052
100EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.90926527

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to3.84494228
2MP0000372_irregular_coat_pigmentation3.34078587
3MP0006072_abnormal_retinal_apoptosis3.05139612
4MP0003136_yellow_coat_color2.89209427
5MP0008877_abnormal_DNA_methylation2.71377415
6MP0004885_abnormal_endolymph2.47572529
7MP0002102_abnormal_ear_morphology2.40301477
8MP0005551_abnormal_eye_electrophysiolog2.15290729
9MP0006292_abnormal_olfactory_placode2.08090286
10MP0004147_increased_porphyrin_level1.97574985
11MP0008875_abnormal_xenobiotic_pharmacok1.97261501
12MP0009379_abnormal_foot_pigmentation1.90595999
13MP0005253_abnormal_eye_physiology1.86820293
14MP0003011_delayed_dark_adaptation1.86181937
15MP0008872_abnormal_physiological_respon1.83778817
16MP0009785_altered_susceptibility_to1.78436622
17MP0002736_abnormal_nociception_after1.76826234
18MP0001835_abnormal_antigen_presentation1.75943705
19MP0001986_abnormal_taste_sensitivity1.71753832
20MP0002876_abnormal_thyroid_physiology1.63081641
21MP0002234_abnormal_pharynx_morphology1.63076657
22MP0001800_abnormal_humoral_immune1.60107174
23MP0002148_abnormal_hypersensitivity_rea1.57653600
24MP0005075_abnormal_melanosome_morpholog1.57075003
25MP0005645_abnormal_hypothalamus_physiol1.56370357
26MP0003646_muscle_fatigue1.53451516
27MP0005000_abnormal_immune_tolerance1.53259095
28MP0005646_abnormal_pituitary_gland1.52469872
29MP0002163_abnormal_gland_morphology1.49938967
30MP0003878_abnormal_ear_physiology1.49653959
31MP0005377_hearing/vestibular/ear_phenot1.49653959
32MP0004142_abnormal_muscle_tone1.49114398
33MP0003866_abnormal_defecation1.46519396
34MP0003763_abnormal_thymus_physiology1.40055970
35MP0002277_abnormal_respiratory_mucosa1.39033554
36MP0009333_abnormal_splenocyte_physiolog1.38935444
37MP0001968_abnormal_touch/_nociception1.37736331
38MP0003283_abnormal_digestive_organ1.34652460
39MP0000685_abnormal_immune_system1.33339550
40MP0008995_early_reproductive_senescence1.33160654
41MP0002723_abnormal_immune_serum1.32794249
42MP0004742_abnormal_vestibular_system1.30582959
43MP0001873_stomach_inflammation1.30543144
44MP0003806_abnormal_nucleotide_metabolis1.30307391
45MP0005084_abnormal_gallbladder_morpholo1.27553927
46MP0002166_altered_tumor_susceptibility1.27037515
47MP0003567_abnormal_fetal_cardiomyocyte1.26529223
48MP0002006_tumorigenesis1.25964254
49MP0003938_abnormal_ear_development1.24246436
50MP0002638_abnormal_pupillary_reflex1.19560354
51MP0002420_abnormal_adaptive_immunity1.18818663
52MP0001819_abnormal_immune_cell1.18640214
53MP0003195_calcinosis1.17756115
54MP0002938_white_spotting1.16045148
55MP0008058_abnormal_DNA_repair1.15719748
56MP0001764_abnormal_homeostasis1.15028434
57MP0001790_abnormal_immune_system1.13274621
58MP0005387_immune_system_phenotype1.13274621
59MP0004145_abnormal_muscle_electrophysio1.13128966
60MP0001501_abnormal_sleep_pattern1.12675513
61MP0000631_abnormal_neuroendocrine_gland1.10972129
62MP0002095_abnormal_skin_pigmentation1.09455881
63MP0004381_abnormal_hair_follicle1.07201404
64MP0005379_endocrine/exocrine_gland_phen1.06821749
65MP0002933_joint_inflammation1.06554517
66MP0002452_abnormal_antigen_presenting1.05430645
67MP0001485_abnormal_pinna_reflex1.04631347
68MP0003718_maternal_effect1.03972127
69MP0003724_increased_susceptibility_to1.02454305
70MP0003786_premature_aging1.02418410
71MP0001919_abnormal_reproductive_system1.01919802
72MP0005025_abnormal_response_to0.97618187
73MP0009697_abnormal_copulation0.97102167
74MP0006276_abnormal_autonomic_nervous0.94273111
75MP0001905_abnormal_dopamine_level0.94007330
76MP0001293_anophthalmia0.92330907
77MP0000647_abnormal_sebaceous_gland0.92137943
78MP0006035_abnormal_mitochondrial_morpho0.90953152
79MP0005085_abnormal_gallbladder_physiolo0.90023836
80MP0000716_abnormal_immune_system0.89783424
81MP0005410_abnormal_fertilization0.88793324
82MP0006036_abnormal_mitochondrial_physio0.86486833
83MP0000689_abnormal_spleen_morphology0.86371737
84MP0000049_abnormal_middle_ear0.85826931
85MP0002751_abnormal_autonomic_nervous0.85784769
86MP0009745_abnormal_behavioral_response0.85573242
87MP0002398_abnormal_bone_marrow0.83635458
88MP0003119_abnormal_digestive_system0.82620039
89MP0000703_abnormal_thymus_morphology0.81360652
90MP0001984_abnormal_olfaction0.81316947
91MP0002272_abnormal_nervous_system0.79113075
92MP0003693_abnormal_embryo_hatching0.78586757
93MP0000383_abnormal_hair_follicle0.78499801
94MP0008961_abnormal_basal_metabolism0.78371012
95MP0003638_abnormal_response/metabolism_0.78064278
96MP0005389_reproductive_system_phenotype0.77747072
97MP0009764_decreased_sensitivity_to0.75603055
98MP0003436_decreased_susceptibility_to0.74834158
99MP0002132_abnormal_respiratory_system0.74293095
100MP0010155_abnormal_intestine_physiology0.74105116

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)4.35174175
2Stomach cancer (HP:0012126)4.09605709
3IgG deficiency (HP:0004315)3.68051819
4Mitochondrial inheritance (HP:0001427)3.64059398
5Aplastic anemia (HP:0001915)3.59656794
6Acute necrotizing encephalopathy (HP:0006965)3.48145115
7Pancreatic cysts (HP:0001737)3.41275932
8Severe combined immunodeficiency (HP:0004430)3.40173624
9True hermaphroditism (HP:0010459)3.39810620
103-Methylglutaconic aciduria (HP:0003535)3.39696543
11Hepatocellular necrosis (HP:0001404)3.37168037
12Increased CSF lactate (HP:0002490)3.21433463
13Colon cancer (HP:0003003)3.13107526
14Increased hepatocellular lipid droplets (HP:0006565)3.05611500
15Hepatic necrosis (HP:0002605)3.04348688
16Abnormal mitochondria in muscle tissue (HP:0008316)3.00109042
17Thyroiditis (HP:0100646)2.98411467
18Pancreatic fibrosis (HP:0100732)2.95498009
19Lipid accumulation in hepatocytes (HP:0006561)2.93203019
20Abnormality of B cell number (HP:0010975)2.91913969
21Acute encephalopathy (HP:0006846)2.89713848
22Progressive macrocephaly (HP:0004481)2.89653192
23Hypoproteinemia (HP:0003075)2.78143823
24Abnormal rod and cone electroretinograms (HP:0008323)2.76401449
25Abnormality of T cell number (HP:0011839)2.72116162
26Molar tooth sign on MRI (HP:0002419)2.71757817
27Abnormality of midbrain morphology (HP:0002418)2.71757817
28Thyroid-stimulating hormone excess (HP:0002925)2.68606809
29Congenital, generalized hypertrichosis (HP:0004540)2.67745347
30Combined immunodeficiency (HP:0005387)2.62716623
31Renal cortical cysts (HP:0000803)2.59449293
32T lymphocytopenia (HP:0005403)2.55711332
33Methylmalonic acidemia (HP:0002912)2.51613148
34Attenuation of retinal blood vessels (HP:0007843)2.50753282
35Absent rod-and cone-mediated responses on ERG (HP:0007688)2.48133889
36Abolished electroretinogram (ERG) (HP:0000550)2.44427136
37Renal Fanconi syndrome (HP:0001994)2.39273947
38Abnormality of eosinophils (HP:0001879)2.38104077
39Abnormality of the pons (HP:0007361)2.36138446
40Abnormality of the prostate (HP:0008775)2.35823136
41Increased serum lactate (HP:0002151)2.35803127
42Optic disc pallor (HP:0000543)2.33138314
43Pancytopenia (HP:0001876)2.32390854
44Concave nail (HP:0001598)2.31339535
45Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.31131102
46Decreased activity of mitochondrial respiratory chain (HP:0008972)2.31131102
47Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.31019609
48Abnormality of alanine metabolism (HP:0010916)2.31019609
49Hyperalaninemia (HP:0003348)2.31019609
50Abnormality of the renal cortex (HP:0011035)2.30427716
51Cerebral edema (HP:0002181)2.30077446
52Methylmalonic aciduria (HP:0012120)2.24062306
53Increased intramyocellular lipid droplets (HP:0012240)2.23304810
54Lactic acidosis (HP:0003128)2.22832170
55B lymphocytopenia (HP:0010976)2.19308651
56Abnormality of T cells (HP:0002843)2.19194115
57Type II lissencephaly (HP:0007260)2.17367857
58Abnormal number of erythroid precursors (HP:0012131)2.17076566
59Short tibia (HP:0005736)2.15104855
60Decreased electroretinogram (ERG) amplitude (HP:0000654)2.14876092
61Reticulocytopenia (HP:0001896)2.12713118
62Increased IgM level (HP:0003496)2.12693516
63Elevated erythrocyte sedimentation rate (HP:0003565)2.10599819
64Sclerocornea (HP:0000647)2.06397589
65Hypoplasia of the pons (HP:0012110)2.06183502
66Medial flaring of the eyebrow (HP:0010747)2.04177290
67Prostate neoplasm (HP:0100787)2.02790862
68Respiratory difficulties (HP:0002880)2.00890382
69Nephronophthisis (HP:0000090)1.99076269
70Abnormality of the renal collecting system (HP:0004742)1.97097056
71Aplasia/Hypoplasia of the tibia (HP:0005772)1.96618017
72Aplasia/hypoplasia of the uterus (HP:0008684)1.96249646
73Type 2 muscle fiber atrophy (HP:0003554)1.94639085
74Absent thumb (HP:0009777)1.93668231
75Decreased central vision (HP:0007663)1.90965430
76Cystic liver disease (HP:0006706)1.89060759
77Hypoplasia of the uterus (HP:0000013)1.87869349
78Conical tooth (HP:0000698)1.86536886
79Anencephaly (HP:0002323)1.86295090
80Lethargy (HP:0001254)1.86270037
81Increased muscle lipid content (HP:0009058)1.86143446
82Stomatitis (HP:0010280)1.85946691
83Pendular nystagmus (HP:0012043)1.85011683
84Postaxial foot polydactyly (HP:0001830)1.84719072
85Cerebral palsy (HP:0100021)1.83648862
86Oral leukoplakia (HP:0002745)1.83005849
87Abnormality of cells of the erythroid lineage (HP:0012130)1.81060346
88Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.80670152
89Retinal dysplasia (HP:0007973)1.80380955
90Male pseudohermaphroditism (HP:0000037)1.78909583
91Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.78589679
92Respiratory failure (HP:0002878)1.78273644
93Exertional dyspnea (HP:0002875)1.78167078
94Cerebellar dysplasia (HP:0007033)1.76471632
95Bilateral microphthalmos (HP:0007633)1.76346306
96Abnormal delayed hypersensitivity skin test (HP:0002963)1.74280377
97Macrocytic anemia (HP:0001972)1.74160246
98IgM deficiency (HP:0002850)1.72527263
99Duplicated collecting system (HP:0000081)1.70413151
100Anhidrosis (HP:0000970)1.69445347

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.84136697
2MAP4K24.18021894
3TESK24.04564340
4ZAK3.70429412
5VRK23.40038983
6KDR2.89866519
7TLK12.78939810
8ADRBK22.43625054
9BUB12.39964086
10BCKDK2.23175592
11PINK12.18823311
12GRK12.07662630
13TAOK32.03405854
14VRK11.95426396
15FRK1.78139638
16TAF11.76367847
17NUAK11.72964409
18PASK1.67119723
19MST41.62768742
20TSSK61.57481570
21INSRR1.53652862
22ITK1.37600267
23TIE11.32372515
24CDK191.29213510
25MKNK11.25607860
26MAP4K11.23900999
27SRPK11.22830024
28GRK61.18075650
29MUSK1.08002066
30KIT1.05088416
31WNK41.02950647
32DYRK21.02272380
33TEC1.00542491
34WNK30.96624389
35IKBKB0.95480515
36PLK40.92573177
37LIMK10.91104735
38MAP3K120.90554021
39PDK20.89692493
40NME10.89319368
41IKBKE0.88077355
42PLK30.87982106
43MATK0.85488326
44MAPK130.83547775
45MAP2K20.83156762
46SYK0.80685242
47OXSR10.79163444
48CSNK1G30.78519037
49BMPR1B0.77014342
50DAPK10.76727080
51FES0.72758540
52LCK0.71615218
53TRIM280.71131869
54STK160.68287435
55LYN0.65815923
56EIF2AK20.65760249
57EIF2AK30.65302944
58RPS6KA50.64118347
59CAMKK20.59318815
60PRKCQ0.59042302
61CSNK1G10.58749652
62IGF1R0.56950505
63CSNK1G20.55187207
64MAPK150.54488885
65PBK0.54457431
66PLK20.53296544
67DAPK20.53094734
68BCR0.52313830
69CSNK1A1L0.51715292
70ADRBK10.50264011
71CDK80.49976353
72MAPKAPK30.49126778
73ATR0.45336867
74GRK70.45249392
75TBK10.44751174
76RPS6KA40.42618060
77MKNK20.42375632
78CSNK2A10.41054290
79ERBB20.40043870
80PIK3CA0.39545116
81CDC70.38789542
82MAP2K70.38439342
83MAP3K140.37812160
84PIK3CG0.36501960
85PAK30.36191170
86AURKB0.36106832
87PIM10.35904371
88CSNK1A10.35772371
89OBSCN0.35354026
90CCNB10.33989027
91STK390.33377677
92CSF1R0.32244525
93BTK0.31827109
94PLK10.30440858
95MYLK0.30200168
96PRKCA0.28310129
97MAPKAPK50.27940514
98CSNK2A20.27402837
99PRKACA0.27319931
100BMPR20.27117573

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.13755053
2Oxidative phosphorylation_Homo sapiens_hsa001903.45465667
3Parkinsons disease_Homo sapiens_hsa050122.92038019
4Primary immunodeficiency_Homo sapiens_hsa053402.90227753
5Ribosome_Homo sapiens_hsa030102.85422967
6RNA polymerase_Homo sapiens_hsa030202.85177939
7Protein export_Homo sapiens_hsa030602.50193548
8Homologous recombination_Homo sapiens_hsa034402.21752887
9Phototransduction_Homo sapiens_hsa047441.95167378
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.91263846
11Huntingtons disease_Homo sapiens_hsa050161.90788657
12Caffeine metabolism_Homo sapiens_hsa002321.86084177
13Alzheimers disease_Homo sapiens_hsa050101.82242055
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.80205251
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.68042578
16Allograft rejection_Homo sapiens_hsa053301.64736075
17Autoimmune thyroid disease_Homo sapiens_hsa053201.63707342
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.58966615
19Linoleic acid metabolism_Homo sapiens_hsa005911.54915338
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.54737640
21Mismatch repair_Homo sapiens_hsa034301.52384529
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.47892290
23Basal transcription factors_Homo sapiens_hsa030221.47325525
24Cardiac muscle contraction_Homo sapiens_hsa042601.46581295
25Graft-versus-host disease_Homo sapiens_hsa053321.46399518
26One carbon pool by folate_Homo sapiens_hsa006701.44880976
27Fanconi anemia pathway_Homo sapiens_hsa034601.41830559
28RNA degradation_Homo sapiens_hsa030181.37060800
29Antigen processing and presentation_Homo sapiens_hsa046121.35552290
30DNA replication_Homo sapiens_hsa030301.34183446
31Tryptophan metabolism_Homo sapiens_hsa003801.31373936
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.29825408
33Pyrimidine metabolism_Homo sapiens_hsa002401.29222633
34Nitrogen metabolism_Homo sapiens_hsa009101.28072309
35Spliceosome_Homo sapiens_hsa030401.26363397
36Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.24907050
37Nucleotide excision repair_Homo sapiens_hsa034201.24048006
38Type I diabetes mellitus_Homo sapiens_hsa049401.24024989
39Purine metabolism_Homo sapiens_hsa002301.23507161
40Base excision repair_Homo sapiens_hsa034101.22065551
41Asthma_Homo sapiens_hsa053101.21847493
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.19980908
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.18451929
44Sulfur metabolism_Homo sapiens_hsa009201.11413130
45Hematopoietic cell lineage_Homo sapiens_hsa046401.10430854
46Non-homologous end-joining_Homo sapiens_hsa034501.01324884
47Butanoate metabolism_Homo sapiens_hsa006501.00311741
48Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.00005882
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.99199275
50RNA transport_Homo sapiens_hsa030130.98645863
51Olfactory transduction_Homo sapiens_hsa047400.98571768
52Propanoate metabolism_Homo sapiens_hsa006400.96035876
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94745385
54Peroxisome_Homo sapiens_hsa041460.91770074
55NF-kappa B signaling pathway_Homo sapiens_hsa040640.90442157
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.89908602
57Chemical carcinogenesis_Homo sapiens_hsa052040.89048941
58Rheumatoid arthritis_Homo sapiens_hsa053230.86843550
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.86377955
60Retinol metabolism_Homo sapiens_hsa008300.86165905
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86147135
62Nicotine addiction_Homo sapiens_hsa050330.77430283
63Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.77421762
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.76200791
65Selenocompound metabolism_Homo sapiens_hsa004500.76037006
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74340922
67Arachidonic acid metabolism_Homo sapiens_hsa005900.73792984
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70177605
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.70061060
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67549211
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66005650
72Folate biosynthesis_Homo sapiens_hsa007900.64338045
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.62682499
74Metabolic pathways_Homo sapiens_hsa011000.61666401
75Taste transduction_Homo sapiens_hsa047420.57597589
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.54277301
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53538779
78Steroid biosynthesis_Homo sapiens_hsa001000.52161906
79T cell receptor signaling pathway_Homo sapiens_hsa046600.51794011
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48732702
81Systemic lupus erythematosus_Homo sapiens_hsa053220.46975164
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42752197
83Morphine addiction_Homo sapiens_hsa050320.42476999
84Ether lipid metabolism_Homo sapiens_hsa005650.38932276
85Collecting duct acid secretion_Homo sapiens_hsa049660.38899918
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37518565
87Glutathione metabolism_Homo sapiens_hsa004800.36869849
88Fat digestion and absorption_Homo sapiens_hsa049750.35295888
89Pyruvate metabolism_Homo sapiens_hsa006200.35014600
90Salivary secretion_Homo sapiens_hsa049700.34803548
91Measles_Homo sapiens_hsa051620.33320870
92ABC transporters_Homo sapiens_hsa020100.32940458
93beta-Alanine metabolism_Homo sapiens_hsa004100.32754225
94Glycerolipid metabolism_Homo sapiens_hsa005610.31314614
95Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.30212805
96NOD-like receptor signaling pathway_Homo sapiens_hsa046210.30199458
97RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.30179796
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.29030470
99Epstein-Barr virus infection_Homo sapiens_hsa051690.28802513
100Sulfur relay system_Homo sapiens_hsa041220.25853899

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