HNRNPA1P39

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.11655462
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.15233551
3sequestering of actin monomers (GO:0042989)4.51455690
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.49048970
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.36274883
6ATP synthesis coupled proton transport (GO:0015986)4.36274883
7cytidine deamination (GO:0009972)4.23682641
8cytidine metabolic process (GO:0046087)4.23682641
9cytidine catabolic process (GO:0006216)4.23682641
10protein neddylation (GO:0045116)4.07944717
11mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.84741950
12establishment of protein localization to mitochondrial membrane (GO:0090151)3.68860788
13protein deneddylation (GO:0000338)3.68547178
14chaperone-mediated protein transport (GO:0072321)3.66515079
15ribosomal small subunit assembly (GO:0000028)3.63493913
16nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.62055935
17proteasome assembly (GO:0043248)3.58677892
18cullin deneddylation (GO:0010388)3.58610661
19respiratory electron transport chain (GO:0022904)3.54680495
20electron transport chain (GO:0022900)3.53516356
21protein complex biogenesis (GO:0070271)3.47101067
22positive regulation of prostaglandin secretion (GO:0032308)3.47021002
23pyrimidine ribonucleoside catabolic process (GO:0046133)3.42958509
24exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.38252600
25regulation of cellular amino acid metabolic process (GO:0006521)3.37851490
26negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.36636436
27metallo-sulfur cluster assembly (GO:0031163)3.34913190
28iron-sulfur cluster assembly (GO:0016226)3.34913190
29mitochondrial respiratory chain complex assembly (GO:0033108)3.27739247
30platelet dense granule organization (GO:0060155)3.26572368
31water-soluble vitamin biosynthetic process (GO:0042364)3.25148498
32RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.18211573
33tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.18211573
34mannosylation (GO:0097502)3.15711123
35DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.14000222
36Arp2/3 complex-mediated actin nucleation (GO:0034314)3.11962663
37signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.08195143
38signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.08195143
39signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.08195143
40mitochondrial respiratory chain complex I assembly (GO:0032981)3.07021566
41NADH dehydrogenase complex assembly (GO:0010257)3.07021566
42mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.07021566
43signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.02123143
44intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.02123143
45positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.99541396
46transcription elongation from RNA polymerase III promoter (GO:0006385)2.99233627
47termination of RNA polymerase III transcription (GO:0006386)2.99233627
48positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.97023089
49kynurenine metabolic process (GO:0070189)2.93259056
50signal transduction involved in cell cycle checkpoint (GO:0072395)2.91707037
51negative regulation of T cell apoptotic process (GO:0070233)2.91674386
52negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.90947065
53negative regulation of ligase activity (GO:0051352)2.90947065
54signal transduction involved in DNA damage checkpoint (GO:0072422)2.90470523
55signal transduction involved in DNA integrity checkpoint (GO:0072401)2.90470523
56regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.89168672
57protein-cofactor linkage (GO:0018065)2.87237153
58tryptophan metabolic process (GO:0006568)2.86167741
59rRNA modification (GO:0000154)2.84367240
60tryptophan catabolic process (GO:0006569)2.84262084
61indole-containing compound catabolic process (GO:0042436)2.84262084
62indolalkylamine catabolic process (GO:0046218)2.84262084
63deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.84136469
64purine deoxyribonucleotide catabolic process (GO:0009155)2.83551703
65oxidative phosphorylation (GO:0006119)2.81602481
66regulation of chronic inflammatory response (GO:0002676)2.81310833
67actin nucleation (GO:0045010)2.80931857
68response to interferon-beta (GO:0035456)2.80712703
69indolalkylamine metabolic process (GO:0006586)2.80385581
70negative regulation by host of viral transcription (GO:0043922)2.79069890
71cytochrome complex assembly (GO:0017004)2.77587993
72positive regulation of fatty acid transport (GO:2000193)2.76336939
73respiratory chain complex IV assembly (GO:0008535)2.72163835
74response to pheromone (GO:0019236)2.70741430
75cellular response to interleukin-15 (GO:0071350)2.70469952
76positive regulation of icosanoid secretion (GO:0032305)2.67477505
77antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.65843817
78regulation of regulatory T cell differentiation (GO:0045589)2.64275660
79positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.62958102
80hydrogen ion transmembrane transport (GO:1902600)2.62055377
81base-excision repair, AP site formation (GO:0006285)2.61605496
82regulation of prostaglandin secretion (GO:0032306)2.61531100
83DNA catabolic process, exonucleolytic (GO:0000738)2.60064823
84positive regulation of interleukin-8 secretion (GO:2000484)2.58071965
85deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.57562547
86DNA double-strand break processing (GO:0000729)2.57351263
87anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.57073645
88RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.56470153
89proton transport (GO:0015992)2.55189282
90regulation of mitotic spindle checkpoint (GO:1903504)2.54671759
91regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.54671759
92pseudouridine synthesis (GO:0001522)2.53612698
93regulation of mitochondrial translation (GO:0070129)2.53089057
94negative T cell selection (GO:0043383)2.50949161
95GPI anchor metabolic process (GO:0006505)2.50741471
96hydrogen transport (GO:0006818)2.50662433
97regulation of T cell receptor signaling pathway (GO:0050856)2.49930246
98protein polyglutamylation (GO:0018095)2.49244666
99cytolysis (GO:0019835)2.49160664
100S-adenosylmethionine metabolic process (GO:0046500)2.48751666

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.22409176
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.94425687
3ELF1_17652178_ChIP-ChIP_JURKAT_Human3.77614941
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.47396673
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.45558384
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.11817452
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.08760306
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.95962440
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.90983439
10ZNF274_21170338_ChIP-Seq_K562_Hela2.71950158
11VDR_23849224_ChIP-Seq_CD4+_Human2.67127755
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.39284936
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.39165528
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.37112202
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.29063633
16IGF1R_20145208_ChIP-Seq_DFB_Human2.27207082
17SRF_21415370_ChIP-Seq_HL-1_Mouse2.24442143
18ELK1_19687146_ChIP-ChIP_HELA_Human2.23956697
19VDR_22108803_ChIP-Seq_LS180_Human2.17855727
20FOXP3_21729870_ChIP-Seq_TREG_Human2.10526541
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.05610976
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.95241955
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.91717893
24CREB1_15753290_ChIP-ChIP_HEK293T_Human1.91356185
25BP1_19119308_ChIP-ChIP_Hs578T_Human1.89572751
26MYC_18940864_ChIP-ChIP_HL60_Human1.86924300
27PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.86430347
28IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.83020787
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.80295844
30STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.59779628
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.57059134
32TAF15_26573619_Chip-Seq_HEK293_Human1.54110756
33EWS_26573619_Chip-Seq_HEK293_Human1.54097184
34IRF8_22096565_ChIP-ChIP_GC-B_Human1.50997934
35TP53_22573176_ChIP-Seq_HFKS_Human1.50141393
36EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.45720832
37FUS_26573619_Chip-Seq_HEK293_Human1.35300877
38HOXB4_20404135_ChIP-ChIP_EML_Mouse1.34807032
39CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.34645177
40POU3F2_20337985_ChIP-ChIP_501MEL_Human1.33105933
41IRF8_21731497_ChIP-ChIP_J774_Mouse1.32865984
42AR_20517297_ChIP-Seq_VCAP_Human1.30655392
43CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.30030480
44E2F4_17652178_ChIP-ChIP_JURKAT_Human1.29304454
45MYC_18358816_ChIP-ChIP_MESCs_Mouse1.29019244
46GATA3_26560356_Chip-Seq_TH2_Human1.28734869
47POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28613230
48FOXA1_27270436_Chip-Seq_PROSTATE_Human1.28186320
49FOXA1_25329375_ChIP-Seq_VCAP_Human1.28186320
50PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.27216505
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.26099563
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25446488
53MYC_18555785_ChIP-Seq_MESCs_Mouse1.25383337
54IRF1_19129219_ChIP-ChIP_H3396_Human1.25332595
55GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25272979
56DCP1A_22483619_ChIP-Seq_HELA_Human1.24707467
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.23606202
58MYB_26560356_Chip-Seq_TH2_Human1.19482956
59POU5F1_16153702_ChIP-ChIP_HESCs_Human1.18443578
60GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17727359
61ER_23166858_ChIP-Seq_MCF-7_Human1.17500921
62PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16985653
63GABP_19822575_ChIP-Seq_HepG2_Human1.16781832
64CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16597359
65MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15704376
66P300_19829295_ChIP-Seq_ESCs_Human1.15572041
67PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12528129
68ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12105774
69LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.11967561
70FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.11804368
71AUTS2_25519132_ChIP-Seq_293T-REX_Human1.10509060
72TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08384586
73IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08198562
74CBP_20019798_ChIP-Seq_JUKART_Human1.08198562
75EGR1_23403033_ChIP-Seq_LIVER_Mouse1.08188569
76ELK1_22589737_ChIP-Seq_MCF10A_Human1.07660629
77SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.07259131
78FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05886564
79SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.05652913
80RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.04715648
81SOX2_19829295_ChIP-Seq_ESCs_Human1.04509608
82NANOG_19829295_ChIP-Seq_ESCs_Human1.04509608
83TTF2_22483619_ChIP-Seq_HELA_Human1.03583297
84NCOR_22424771_ChIP-Seq_293T_Human1.02843002
85GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.02842668
86NFE2_27457419_Chip-Seq_LIVER_Mouse1.02803611
87ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.02065170
88E2F1_18555785_ChIP-Seq_MESCs_Mouse1.00750653
89ERG_20517297_ChIP-Seq_VCAP_Human1.00298806
90EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.98572516
91SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98524609
92MYC_19030024_ChIP-ChIP_MESCs_Mouse0.98151850
93GATA3_27048872_Chip-Seq_THYMUS_Human0.98127987
94PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97969535
95FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97929102
96HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.96821939
97EZH2_22144423_ChIP-Seq_EOC_Human0.96158892
98HTT_18923047_ChIP-ChIP_STHdh_Human0.95377310
99CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.94681459
100CIITA_25753668_ChIP-Seq_RAJI_Human0.93535000

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.24599826
2MP0006072_abnormal_retinal_apoptosis3.20200265
3MP0006292_abnormal_olfactory_placode2.62405250
4MP0008875_abnormal_xenobiotic_pharmacok2.41300332
5MP0001835_abnormal_antigen_presentation2.25605660
6MP0009785_altered_susceptibility_to2.18799890
7MP0004147_increased_porphyrin_level2.14042905
8MP0003786_premature_aging2.07953730
9MP0008995_early_reproductive_senescence2.06842277
10MP0002102_abnormal_ear_morphology2.00432198
11MP0005084_abnormal_gallbladder_morpholo1.99691066
12MP0000372_irregular_coat_pigmentation1.99350003
13MP0003011_delayed_dark_adaptation1.88761445
14MP0003195_calcinosis1.88756876
15MP0005551_abnormal_eye_electrophysiolog1.87214906
16MP0008058_abnormal_DNA_repair1.86811188
17MP0005253_abnormal_eye_physiology1.86562449
18MP0005645_abnormal_hypothalamus_physiol1.83679630
19MP0008872_abnormal_physiological_respon1.81690934
20MP0003763_abnormal_thymus_physiology1.80423777
21MP0002653_abnormal_ependyma_morphology1.67547535
22MP0005646_abnormal_pituitary_gland1.67333975
23MP0001968_abnormal_touch/_nociception1.59194391
24MP0003878_abnormal_ear_physiology1.57784181
25MP0005377_hearing/vestibular/ear_phenot1.57784181
26MP0008877_abnormal_DNA_methylation1.57186698
27MP0008789_abnormal_olfactory_epithelium1.56293982
28MP0001986_abnormal_taste_sensitivity1.54802320
29MP0002006_tumorigenesis1.52095088
30MP0001529_abnormal_vocalization1.51676591
31MP0002736_abnormal_nociception_after1.51624408
32MP0002166_altered_tumor_susceptibility1.50107842
33MP0001764_abnormal_homeostasis1.49207113
34MP0001984_abnormal_olfaction1.48127731
35MP0005000_abnormal_immune_tolerance1.46465248
36MP0002148_abnormal_hypersensitivity_rea1.43151097
37MP0003866_abnormal_defecation1.39452691
38MP0001800_abnormal_humoral_immune1.37701699
39MP0000685_abnormal_immune_system1.35404237
40MP0001905_abnormal_dopamine_level1.34761733
41MP0005389_reproductive_system_phenotype1.29893293
42MP0003724_increased_susceptibility_to1.27362636
43MP0002723_abnormal_immune_serum1.24603926
44MP0010386_abnormal_urinary_bladder1.23997734
45MP0006036_abnormal_mitochondrial_physio1.23461237
46MP0001919_abnormal_reproductive_system1.21553123
47MP0002420_abnormal_adaptive_immunity1.20771082
48MP0002234_abnormal_pharynx_morphology1.20020282
49MP0003252_abnormal_bile_duct1.19698989
50MP0002277_abnormal_respiratory_mucosa1.19510085
51MP0001819_abnormal_immune_cell1.18884541
52MP0001873_stomach_inflammation1.16952918
53MP0002837_dystrophic_cardiac_calcinosis1.16166856
54MP0005075_abnormal_melanosome_morpholog1.11045754
55MP0005025_abnormal_response_to1.10864152
56MP0003880_abnormal_central_pattern1.07981101
57MP0006276_abnormal_autonomic_nervous1.07693318
58MP0002638_abnormal_pupillary_reflex1.06107406
59MP0003646_muscle_fatigue1.05716618
60MP0005387_immune_system_phenotype1.05075387
61MP0001790_abnormal_immune_system1.05075387
62MP0004142_abnormal_muscle_tone1.04188238
63MP0006035_abnormal_mitochondrial_morpho1.04094767
64MP0005085_abnormal_gallbladder_physiolo1.03085485
65MP0002160_abnormal_reproductive_system1.02783289
66MP0000689_abnormal_spleen_morphology1.02712656
67MP0004885_abnormal_endolymph1.01881582
68MP0002876_abnormal_thyroid_physiology1.01537812
69MP0004145_abnormal_muscle_electrophysio1.01299997
70MP0003806_abnormal_nucleotide_metabolis1.01235662
71MP0000716_abnormal_immune_system1.00698869
72MP0000703_abnormal_thymus_morphology0.99085818
73MP0009333_abnormal_splenocyte_physiolog0.98807335
74MP0002452_abnormal_antigen_presenting0.98193451
75MP0002398_abnormal_bone_marrow0.97359648
76MP0009697_abnormal_copulation0.96155096
77MP0005499_abnormal_olfactory_system0.95954329
78MP0005394_taste/olfaction_phenotype0.95954329
79MP0002722_abnormal_immune_system0.95750273
80MP0005167_abnormal_blood-brain_barrier0.95064089
81MP0003718_maternal_effect0.93202693
82MP0000631_abnormal_neuroendocrine_gland0.91884657
83MP0002933_joint_inflammation0.91106479
84MP0000465_gastrointestinal_hemorrhage0.90288342
85MP0003137_abnormal_impulse_conducting0.89712546
86MP0002405_respiratory_system_inflammati0.88965402
87MP0001501_abnormal_sleep_pattern0.88806131
88MP0005410_abnormal_fertilization0.86482573
89MP0001485_abnormal_pinna_reflex0.85731726
90MP0004043_abnormal_pH_regulation0.85369340
91MP0010094_abnormal_chromosome_stability0.84949987
92MP0002751_abnormal_autonomic_nervous0.82485105
93MP0003436_decreased_susceptibility_to0.82282018
94MP0009764_decreased_sensitivity_to0.81798908
95MP0004133_heterotaxia0.81142926
96MP0009745_abnormal_behavioral_response0.80408682
97MP0002095_abnormal_skin_pigmentation0.80322966
98MP0002272_abnormal_nervous_system0.78451467
99MP0002429_abnormal_blood_cell0.76978196
100MP0010155_abnormal_intestine_physiology0.76084380

Predicted human phenotypes

RankGene SetZ-score
1Mitochondrial inheritance (HP:0001427)4.01822631
23-Methylglutaconic aciduria (HP:0003535)3.85491755
3Severe combined immunodeficiency (HP:0004430)3.80916467
4Acute necrotizing encephalopathy (HP:0006965)3.80797745
5Hepatocellular necrosis (HP:0001404)3.73551043
6Abnormal mitochondria in muscle tissue (HP:0008316)3.56454630
7Increased CSF lactate (HP:0002490)3.43213997
8Pancreatic cysts (HP:0001737)3.41849366
9Hepatic necrosis (HP:0002605)3.41253843
10Congenital stationary night blindness (HP:0007642)3.39914823
11IgG deficiency (HP:0004315)3.38433975
12True hermaphroditism (HP:0010459)3.32882070
13Increased hepatocellular lipid droplets (HP:0006565)3.25139627
14Acute encephalopathy (HP:0006846)3.22310238
15Aplastic anemia (HP:0001915)3.17059628
16Pancreatic fibrosis (HP:0100732)3.16912016
17Progressive macrocephaly (HP:0004481)3.08016059
18Lipid accumulation in hepatocytes (HP:0006561)3.06108307
19Methylmalonic acidemia (HP:0002912)3.01277374
20Thyroiditis (HP:0100646)2.96977606
21Combined immunodeficiency (HP:0005387)2.94615463
22T lymphocytopenia (HP:0005403)2.90153462
23Elevated erythrocyte sedimentation rate (HP:0003565)2.88895337
24Increased intramyocellular lipid droplets (HP:0012240)2.88158663
25Abnormality of T cell number (HP:0011839)2.86230302
26Colon cancer (HP:0003003)2.84932568
27Hypoproteinemia (HP:0003075)2.82187561
28Abnormality of B cell number (HP:0010975)2.80450894
29Renal cortical cysts (HP:0000803)2.78916871
30Abolished electroretinogram (ERG) (HP:0000550)2.72247635
31Absent rod-and cone-mediated responses on ERG (HP:0007688)2.70946214
32Renal Fanconi syndrome (HP:0001994)2.64230104
33Nephronophthisis (HP:0000090)2.60604873
34Cerebral edema (HP:0002181)2.60321415
35Methylmalonic aciduria (HP:0012120)2.58798088
36Attenuation of retinal blood vessels (HP:0007843)2.57274513
37Type I transferrin isoform profile (HP:0003642)2.52851139
38Increased serum lactate (HP:0002151)2.51886282
39Abnormality of T cells (HP:0002843)2.49758317
40Optic disc pallor (HP:0000543)2.48949530
41Molar tooth sign on MRI (HP:0002419)2.45721436
42Abnormality of midbrain morphology (HP:0002418)2.45721436
43Abnormality of eosinophils (HP:0001879)2.44709903
44Pancytopenia (HP:0001876)2.43382884
45Stomach cancer (HP:0012126)2.43075461
46Lactic acidosis (HP:0003128)2.41891151
47Increased muscle lipid content (HP:0009058)2.40252073
48Decreased activity of mitochondrial respiratory chain (HP:0008972)2.36819618
49Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.36819618
50Abnormal glycosylation (HP:0012345)2.36149631
51Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.36149631
52Abnormal protein N-linked glycosylation (HP:0012347)2.36149631
53Abnormal protein glycosylation (HP:0012346)2.36149631
54Abnormal rod and cone electroretinograms (HP:0008323)2.35585197
55B lymphocytopenia (HP:0010976)2.31498247
56Abnormality of the prostate (HP:0008775)2.28718576
57Aplasia/hypoplasia of the uterus (HP:0008684)2.28035938
58Abnormality of the renal cortex (HP:0011035)2.27351369
59Medial flaring of the eyebrow (HP:0010747)2.26170519
60Abnormality of dicarboxylic acid metabolism (HP:0010995)2.25875715
61Dicarboxylic aciduria (HP:0003215)2.25875715
62Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.24025180
63Hyperglycinemia (HP:0002154)2.22497015
64Type 2 muscle fiber atrophy (HP:0003554)2.18636715
65Decreased electroretinogram (ERG) amplitude (HP:0000654)2.17476165
66Respiratory failure (HP:0002878)2.13474115
67Exertional dyspnea (HP:0002875)2.12750003
68Increased IgM level (HP:0003496)2.12659438
69Abnormality of the renal medulla (HP:0100957)2.11694071
70Lethargy (HP:0001254)2.07772624
71Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.07521029
72Abnormality of alanine metabolism (HP:0010916)2.07521029
73Hyperalaninemia (HP:0003348)2.07521029
74Stomatitis (HP:0010280)2.04625565
75Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.02337886
76Decreased central vision (HP:0007663)2.02205299
77Autoimmune hemolytic anemia (HP:0001890)2.01342314
78Abnormal biliary tract physiology (HP:0012439)2.01202936
79Bile duct proliferation (HP:0001408)2.01202936
80Hypoplasia of the uterus (HP:0000013)2.00885675
81Sclerocornea (HP:0000647)1.98529976
82Generalized aminoaciduria (HP:0002909)1.95552230
83Cerebral palsy (HP:0100021)1.94983270
84Autoimmune thrombocytopenia (HP:0001973)1.92917518
85Pendular nystagmus (HP:0012043)1.91957434
86Encephalitis (HP:0002383)1.91045297
87Abnormal number of erythroid precursors (HP:0012131)1.90806839
88Congenital, generalized hypertrichosis (HP:0004540)1.88186522
89Thyroid-stimulating hormone excess (HP:0002925)1.87329480
90Muscle fiber atrophy (HP:0100295)1.86968451
91Abnormality of serum amino acid levels (HP:0003112)1.86460052
92Eosinophilia (HP:0001880)1.85355401
93IgM deficiency (HP:0002850)1.84613355
94Aplasia/Hypoplasia of the spleen (HP:0010451)1.83723360
95Abnormality of the vitamin B12 metabolism (HP:0004341)1.82654402
96Abnormality of the labia minora (HP:0012880)1.82213106
97Abnormality of T cell physiology (HP:0011840)1.81883769
98Exercise intolerance (HP:0003546)1.81434153
99Cystic liver disease (HP:0006706)1.81019917
100Panhypogammaglobulinemia (HP:0003139)1.80175880

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK24.41077546
2TXK4.33661303
3MAP4K24.12999460
4ZAK3.55652847
5VRK23.26951465
6KDR3.14755397
7BCKDK2.59675708
8TAOK32.55608976
9TLK12.51232049
10ADRBK22.34186536
11NUAK12.15614197
12GRK12.02399984
13VRK11.94553105
14BUB11.59031379
15MAP4K11.52210207
16MST41.48009741
17ITK1.39564469
18SRPK11.35834553
19PINK11.32086025
20STK161.28316811
21EIF2AK31.23338678
22LIMK11.22007061
23WNK31.21660402
24PASK1.19039984
25FRK1.18917030
26TRIM281.14060579
27BMPR1B1.12946201
28TEC1.08108797
29WNK41.06997990
30GRK61.06319688
31NME11.05089049
32MKNK11.04678849
33TAF11.02025624
34CSNK1G31.00012413
35PBK0.99227901
36KIT0.97583711
37ERBB30.92462355
38RPS6KA50.91427581
39CDK190.89021796
40DYRK20.86205452
41SYK0.82326387
42BCR0.80078902
43OXSR10.79601149
44PRKCQ0.78924165
45TIE10.78772005
46CSNK1A1L0.78396291
47EIF2AK20.78223858
48CSNK1G10.77433933
49TESK10.76100757
50MAP2K70.75403944
51PLK30.75331391
52DAPK10.74939654
53CSNK1G20.74660387
54IKBKE0.72946176
55IKBKB0.72285193
56MAPK130.70700260
57EPHA40.69904460
58LCK0.68746788
59MAP3K120.66300907
60INSRR0.65533235
61GRK70.64938516
62MAP2K20.64156098
63CAMKK20.63431077
64FES0.61765777
65NEK10.60833902
66LYN0.60660594
67RPS6KA40.60627828
68CDC70.60435462
69CSF1R0.56406673
70PLK40.55631333
71GRK50.55436476
72FLT30.54074281
73MATK0.53985375
74ATR0.51008244
75TBK10.50631475
76ADRBK10.50339703
77BTK0.46503826
78SCYL20.45656345
79IGF1R0.45035179
80BRSK20.44975029
81PLK20.44730177
82MAP3K40.42852026
83AURKB0.41507454
84TSSK60.41122897
85CSNK1A10.41013065
86PKN10.40425835
87CSNK2A10.39748451
88PLK10.39698562
89STK390.37174239
90OBSCN0.36724600
91CDK80.35648140
92ZAP700.35131393
93PIM10.35126284
94TNK20.34833169
95MAP2K60.33984975
96AURKA0.33924556
97PIK3CG0.32876671
98JAK30.31163563
99CSNK2A20.30019752
100PRKCA0.29587759

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.32689818
2Oxidative phosphorylation_Homo sapiens_hsa001903.44120847
3Primary immunodeficiency_Homo sapiens_hsa053403.19343815
4Parkinsons disease_Homo sapiens_hsa050122.94768875
5RNA polymerase_Homo sapiens_hsa030202.49331247
6Protein export_Homo sapiens_hsa030602.41220374
7Ribosome_Homo sapiens_hsa030102.36294748
8Caffeine metabolism_Homo sapiens_hsa002322.14365297
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.04902172
10Huntingtons disease_Homo sapiens_hsa050161.82827190
11Alzheimers disease_Homo sapiens_hsa050101.79383312
12Homologous recombination_Homo sapiens_hsa034401.77510537
13Graft-versus-host disease_Homo sapiens_hsa053321.71015266
14Allograft rejection_Homo sapiens_hsa053301.69524600
15Autoimmune thyroid disease_Homo sapiens_hsa053201.67624152
16Nitrogen metabolism_Homo sapiens_hsa009101.65410152
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.64576467
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.64383628
19Antigen processing and presentation_Homo sapiens_hsa046121.61194739
20Phototransduction_Homo sapiens_hsa047441.60769917
21Mismatch repair_Homo sapiens_hsa034301.54094835
22Propanoate metabolism_Homo sapiens_hsa006401.50483719
23Type I diabetes mellitus_Homo sapiens_hsa049401.49218167
24DNA replication_Homo sapiens_hsa030301.49000227
25Fanconi anemia pathway_Homo sapiens_hsa034601.46518438
26Spliceosome_Homo sapiens_hsa030401.45867454
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.44663891
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.44588233
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.43696647
30RNA degradation_Homo sapiens_hsa030181.38237630
31Asthma_Homo sapiens_hsa053101.36380759
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.30733340
33Cardiac muscle contraction_Homo sapiens_hsa042601.30344044
34Butanoate metabolism_Homo sapiens_hsa006501.28454343
35Basal transcription factors_Homo sapiens_hsa030221.28102945
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25315606
37Tryptophan metabolism_Homo sapiens_hsa003801.22961863
38Pyrimidine metabolism_Homo sapiens_hsa002401.21979521
39Base excision repair_Homo sapiens_hsa034101.21004854
40One carbon pool by folate_Homo sapiens_hsa006701.19462961
41Peroxisome_Homo sapiens_hsa041461.16671030
42Linoleic acid metabolism_Homo sapiens_hsa005911.15694271
43Nucleotide excision repair_Homo sapiens_hsa034201.15605027
44Hematopoietic cell lineage_Homo sapiens_hsa046401.15134045
45Sulfur metabolism_Homo sapiens_hsa009201.11310560
46Rheumatoid arthritis_Homo sapiens_hsa053231.07255290
47Purine metabolism_Homo sapiens_hsa002301.06985509
48Fatty acid elongation_Homo sapiens_hsa000621.03622177
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.00238716
50Systemic lupus erythematosus_Homo sapiens_hsa053221.00068545
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97332037
52Non-homologous end-joining_Homo sapiens_hsa034500.91668512
53Retinol metabolism_Homo sapiens_hsa008300.91135713
54RNA transport_Homo sapiens_hsa030130.90273968
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.86373457
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.84536554
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.82675119
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80601465
59Chemical carcinogenesis_Homo sapiens_hsa052040.77806218
60Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.77162302
61Maturity onset diabetes of the young_Homo sapiens_hsa049500.75453264
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74558347
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72636708
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.69180981
65Metabolic pathways_Homo sapiens_hsa011000.68120058
66Selenocompound metabolism_Homo sapiens_hsa004500.66168444
67Olfactory transduction_Homo sapiens_hsa047400.64942243
68Glutathione metabolism_Homo sapiens_hsa004800.64777448
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62504041
70Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.61369280
71T cell receptor signaling pathway_Homo sapiens_hsa046600.59974444
72Primary bile acid biosynthesis_Homo sapiens_hsa001200.59158604
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58333786
74Steroid biosynthesis_Homo sapiens_hsa001000.56282154
75Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.55384887
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54252130
77Collecting duct acid secretion_Homo sapiens_hsa049660.53986343
78Regulation of autophagy_Homo sapiens_hsa041400.53201150
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.52585173
80Nicotine addiction_Homo sapiens_hsa050330.52462156
81Arachidonic acid metabolism_Homo sapiens_hsa005900.52063727
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48938795
83Taste transduction_Homo sapiens_hsa047420.48508615
84NF-kappa B signaling pathway_Homo sapiens_hsa040640.47500018
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45935972
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.45282021
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43179441
88NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42286254
89Folate biosynthesis_Homo sapiens_hsa007900.40970735
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38887301
91Ether lipid metabolism_Homo sapiens_hsa005650.38549192
92Fatty acid degradation_Homo sapiens_hsa000710.36407619
93RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.35327976
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35312565
95Fatty acid metabolism_Homo sapiens_hsa012120.33173338
96Sulfur relay system_Homo sapiens_hsa041220.32829206
97N-Glycan biosynthesis_Homo sapiens_hsa005100.32763556
98Fat digestion and absorption_Homo sapiens_hsa049750.32468362
99Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.32442821
100Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.31641631

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