HNRNPA1P38

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.44971424
2DNA deamination (GO:0045006)6.26269139
3energy coupled proton transport, down electrochemical gradient (GO:0015985)6.14291475
4ATP synthesis coupled proton transport (GO:0015986)6.14291475
5chaperone-mediated protein transport (GO:0072321)4.81423121
6ribosomal small subunit assembly (GO:0000028)4.62460472
7mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.61386259
8regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.58473940
9rRNA modification (GO:0000154)4.51510795
10establishment of protein localization to mitochondrial membrane (GO:0090151)4.37207879
11protein neddylation (GO:0045116)4.21483047
12respiratory electron transport chain (GO:0022904)4.11454231
13cytidine deamination (GO:0009972)4.11444813
14cytidine metabolic process (GO:0046087)4.11444813
15cytidine catabolic process (GO:0006216)4.11444813
16electron transport chain (GO:0022900)4.09952668
17sequestering of actin monomers (GO:0042989)4.05210942
18behavioral response to nicotine (GO:0035095)3.94608078
19viral transcription (GO:0019083)3.90172202
20maturation of SSU-rRNA (GO:0030490)3.89870198
21nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.88761482
22translational termination (GO:0006415)3.86598443
23proteasome assembly (GO:0043248)3.85348117
24exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.80561655
25mitochondrial respiratory chain complex I assembly (GO:0032981)3.76534153
26NADH dehydrogenase complex assembly (GO:0010257)3.76534153
27mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.76534153
28protein complex biogenesis (GO:0070271)3.69546524
29SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.65935567
30ribosomal large subunit biogenesis (GO:0042273)3.61321276
31cotranslational protein targeting to membrane (GO:0006613)3.58494365
32mitochondrial respiratory chain complex assembly (GO:0033108)3.58472687
33protein targeting to ER (GO:0045047)3.55520712
34ATP biosynthetic process (GO:0006754)3.53701476
35purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.48857740
36purine nucleoside triphosphate biosynthetic process (GO:0009145)3.46302958
37translational elongation (GO:0006414)3.45394093
38preassembly of GPI anchor in ER membrane (GO:0016254)3.42007113
39rRNA methylation (GO:0031167)3.39693707
40pyrimidine ribonucleoside catabolic process (GO:0046133)3.39191389
41establishment of protein localization to endoplasmic reticulum (GO:0072599)3.37715637
42negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.35251531
43protein localization to endoplasmic reticulum (GO:0070972)3.34809324
44GTP biosynthetic process (GO:0006183)3.33519242
45respiratory chain complex IV assembly (GO:0008535)3.29690534
46cellular ketone body metabolic process (GO:0046950)3.28276337
47RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.22448057
48tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.22448057
49protein deneddylation (GO:0000338)3.21386776
50base-excision repair, AP site formation (GO:0006285)3.20311006
51translation (GO:0006412)3.20089775
52regulation of cellular amino acid metabolic process (GO:0006521)3.14171076
53cullin deneddylation (GO:0010388)3.12825599
54purine nucleobase biosynthetic process (GO:0009113)3.12560617
55ribonucleoside triphosphate biosynthetic process (GO:0009201)3.07951385
56DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.06971129
57UTP metabolic process (GO:0046051)3.06466063
58water-soluble vitamin biosynthetic process (GO:0042364)3.05043902
59mannosylation (GO:0097502)3.03469804
60signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.03031567
61signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.03031567
62signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.03031567
63oxidative phosphorylation (GO:0006119)3.01120135
64response to pheromone (GO:0019236)2.97354195
65guanosine-containing compound biosynthetic process (GO:1901070)2.96438781
66intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.95772539
67signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.95772539
68pseudouridine synthesis (GO:0001522)2.93756761
69positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.93433323
70translational initiation (GO:0006413)2.93184475
71spliceosomal snRNP assembly (GO:0000387)2.92813630
72ketone body metabolic process (GO:1902224)2.92099982
73nucleobase biosynthetic process (GO:0046112)2.91440642
74negative regulation of ligase activity (GO:0051352)2.90931663
75negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.90931663
76hydrogen ion transmembrane transport (GO:1902600)2.90107611
77cellular protein complex disassembly (GO:0043624)2.89988409
78cytochrome complex assembly (GO:0017004)2.89342945
79UTP biosynthetic process (GO:0006228)2.89300160
80regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.89230834
81nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.89149635
82purine nucleoside monophosphate biosynthetic process (GO:0009127)2.88676193
83purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.88676193
84signal transduction involved in DNA damage checkpoint (GO:0072422)2.87088839
85signal transduction involved in DNA integrity checkpoint (GO:0072401)2.87088839
86signal transduction involved in cell cycle checkpoint (GO:0072395)2.86011026
87negative regulation of telomere maintenance (GO:0032205)2.82197805
88termination of RNA polymerase III transcription (GO:0006386)2.82003428
89transcription elongation from RNA polymerase III promoter (GO:0006385)2.82003428
90rRNA processing (GO:0006364)2.82002076
91cellular component biogenesis (GO:0044085)2.81719921
92chromatin remodeling at centromere (GO:0031055)2.81279739
93intracellular protein transmembrane import (GO:0044743)2.78735918
94GPI anchor metabolic process (GO:0006505)2.78633461
95nucleoside triphosphate biosynthetic process (GO:0009142)2.78453722
96viral life cycle (GO:0019058)2.77909065
97epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.77182130
98rRNA metabolic process (GO:0016072)2.76308908
99indolalkylamine metabolic process (GO:0006586)2.76004641
100CENP-A containing nucleosome assembly (GO:0034080)2.75236750

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.37685342
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.32283039
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.83565371
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.54949507
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.34555635
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.27544983
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.20443780
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.83705396
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.75881774
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.63579936
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.55810836
12ELK1_19687146_ChIP-ChIP_HELA_Human2.48784833
13VDR_23849224_ChIP-Seq_CD4+_Human2.43171128
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.41984690
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.41591343
16ZNF274_21170338_ChIP-Seq_K562_Hela2.38386883
17VDR_22108803_ChIP-Seq_LS180_Human2.36701284
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.35378979
19BP1_19119308_ChIP-ChIP_Hs578T_Human2.25548589
20EZH2_22144423_ChIP-Seq_EOC_Human2.25445768
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.15961904
22FOXP3_21729870_ChIP-Seq_TREG_Human2.05560256
23IGF1R_20145208_ChIP-Seq_DFB_Human1.89700667
24EWS_26573619_Chip-Seq_HEK293_Human1.89283849
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.86571579
26E2F4_17652178_ChIP-ChIP_JURKAT_Human1.84096439
27SRF_21415370_ChIP-Seq_HL-1_Mouse1.80539046
28TAF15_26573619_Chip-Seq_HEK293_Human1.74971962
29MYC_18940864_ChIP-ChIP_HL60_Human1.73960617
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.71907400
31YY1_21170310_ChIP-Seq_MESCs_Mouse1.68527541
32MYC_18358816_ChIP-ChIP_MESCs_Mouse1.62490134
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.59120565
34E2F7_22180533_ChIP-Seq_HELA_Human1.55703814
35FUS_26573619_Chip-Seq_HEK293_Human1.53417091
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.52510297
37TTF2_22483619_ChIP-Seq_HELA_Human1.49617994
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49055405
39DCP1A_22483619_ChIP-Seq_HELA_Human1.46215028
40POU5F1_16153702_ChIP-ChIP_HESCs_Human1.43247431
41TP53_22573176_ChIP-Seq_HFKS_Human1.41616004
42P300_19829295_ChIP-Seq_ESCs_Human1.40179372
43MYC_19030024_ChIP-ChIP_MESCs_Mouse1.38079099
44MYC_19079543_ChIP-ChIP_MESCs_Mouse1.35797045
45PADI4_21655091_ChIP-ChIP_MCF-7_Human1.35055152
46ER_23166858_ChIP-Seq_MCF-7_Human1.34560933
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33160608
48FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.31027514
49PCGF2_27294783_Chip-Seq_NPCs_Mouse1.27829178
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.27687852
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26683674
52IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.26593897
53FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26335868
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.26335868
55EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.26081928
56SOX2_19829295_ChIP-Seq_ESCs_Human1.25823486
57NANOG_19829295_ChIP-Seq_ESCs_Human1.25823486
58GABP_19822575_ChIP-Seq_HepG2_Human1.25130225
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24617673
60GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23322154
61CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.23279730
62ELK1_22589737_ChIP-Seq_MCF10A_Human1.21980132
63EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17980053
64HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16986136
65IRF1_19129219_ChIP-ChIP_H3396_Human1.13687149
66THAP11_20581084_ChIP-Seq_MESCs_Mouse1.13431870
67HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.13355631
68E2F1_18555785_ChIP-Seq_MESCs_Mouse1.11925553
69POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.10009308
70IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.09759785
71POU3F2_20337985_ChIP-ChIP_501MEL_Human1.08973151
72AR_20517297_ChIP-Seq_VCAP_Human1.08613752
73ZFP57_27257070_Chip-Seq_ESCs_Mouse1.06272577
74TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03080244
75NOTCH1_21737748_ChIP-Seq_TLL_Human1.02472645
76XRN2_22483619_ChIP-Seq_HELA_Human1.02287490
77RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01936011
78EGR1_23403033_ChIP-Seq_LIVER_Mouse1.01213722
79SOX2_16153702_ChIP-ChIP_HESCs_Human1.00939340
80ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98865826
81ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.97522728
82NANOG_16153702_ChIP-ChIP_HESCs_Human0.97481564
83BMI1_23680149_ChIP-Seq_NPCS_Mouse0.97100712
84SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96612160
85ERG_20517297_ChIP-Seq_VCAP_Human0.93786289
86HTT_18923047_ChIP-ChIP_STHdh_Human0.93361389
87AUTS2_25519132_ChIP-Seq_293T-REX_Human0.93214659
88NFE2_27457419_Chip-Seq_LIVER_Mouse0.92549607
89CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.91455802
90MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.91217404
91NCOR_22424771_ChIP-Seq_293T_Human0.90557667
92FOXA1_21572438_ChIP-Seq_LNCaP_Human0.89581439
93CBP_20019798_ChIP-Seq_JUKART_Human0.89454705
94IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89454705
95TCF4_22108803_ChIP-Seq_LS180_Human0.88213698
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.87913432
97HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.86200360
98ETV2_25802403_ChIP-Seq_MESCs_Mouse0.85647999
99HOXB7_26014856_ChIP-Seq_BT474_Human0.84824658
100SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.84306869

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation3.54073227
2MP0006292_abnormal_olfactory_placode3.53563780
3MP0002102_abnormal_ear_morphology2.67797511
4MP0004147_increased_porphyrin_level2.54552230
5MP0005671_abnormal_response_to2.49206520
6MP0008877_abnormal_DNA_methylation2.41292685
7MP0008995_early_reproductive_senescence2.15143416
8MP0005084_abnormal_gallbladder_morpholo2.13949061
9MP0006072_abnormal_retinal_apoptosis2.07151209
10MP0002736_abnormal_nociception_after2.04087352
11MP0001529_abnormal_vocalization2.02953278
12MP0008875_abnormal_xenobiotic_pharmacok1.97945316
13MP0008058_abnormal_DNA_repair1.95014319
14MP0001293_anophthalmia1.92736098
15MP0008872_abnormal_physiological_respon1.90426787
16MP0002234_abnormal_pharynx_morphology1.87563019
17MP0003011_delayed_dark_adaptation1.87217874
18MP0002277_abnormal_respiratory_mucosa1.84958388
19MP0003786_premature_aging1.83141891
20MP0002938_white_spotting1.78379491
21MP0001485_abnormal_pinna_reflex1.71330047
22MP0005646_abnormal_pituitary_gland1.70795006
23MP0005551_abnormal_eye_electrophysiolog1.68464489
24MP0003136_yellow_coat_color1.64264986
25MP0003283_abnormal_digestive_organ1.62966333
26MP0005645_abnormal_hypothalamus_physiol1.59475589
27MP0004885_abnormal_endolymph1.58841023
28MP0003693_abnormal_embryo_hatching1.57934141
29MP0003718_maternal_effect1.50235211
30MP0004957_abnormal_blastocyst_morpholog1.47716181
31MP0001968_abnormal_touch/_nociception1.47388868
32MP0003787_abnormal_imprinting1.46570761
33MP0001835_abnormal_antigen_presentation1.46200612
34MP0003195_calcinosis1.43776961
35MP0010094_abnormal_chromosome_stability1.38871643
36MP0009785_altered_susceptibility_to1.38569098
37MP0002653_abnormal_ependyma_morphology1.38389341
38MP0000631_abnormal_neuroendocrine_gland1.37269080
39MP0000049_abnormal_middle_ear1.31717190
40MP0006036_abnormal_mitochondrial_physio1.28013041
41MP0004142_abnormal_muscle_tone1.27020613
42MP0005253_abnormal_eye_physiology1.26310158
43MP0009333_abnormal_splenocyte_physiolog1.22463815
44MP0002837_dystrophic_cardiac_calcinosis1.19665831
45MP0001905_abnormal_dopamine_level1.14312560
46MP0000372_irregular_coat_pigmentation1.13198729
47MP0003567_abnormal_fetal_cardiomyocyte1.12196025
48MP0003646_muscle_fatigue1.12069295
49MP0001873_stomach_inflammation1.10492034
50MP0003938_abnormal_ear_development1.09140158
51MP0002822_catalepsy1.08414208
52MP0003186_abnormal_redox_activity1.06998189
53MP0003121_genomic_imprinting1.05570215
54MP0002272_abnormal_nervous_system1.05323843
55MP0009697_abnormal_copulation1.03867411
56MP0002751_abnormal_autonomic_nervous1.03617237
57MP0005389_reproductive_system_phenotype1.03359767
58MP0002160_abnormal_reproductive_system1.02814080
59MP0005085_abnormal_gallbladder_physiolo1.02655207
60MP0005379_endocrine/exocrine_gland_phen1.02509104
61MP0008789_abnormal_olfactory_epithelium1.01861397
62MP0003111_abnormal_nucleus_morphology0.97560018
63MP0006035_abnormal_mitochondrial_morpho0.95620845
64MP0001986_abnormal_taste_sensitivity0.94841505
65MP0005377_hearing/vestibular/ear_phenot0.94837668
66MP0003878_abnormal_ear_physiology0.94837668
67MP0008007_abnormal_cellular_replicative0.93600327
68MP0001348_abnormal_lacrimal_gland0.92708912
69MP0006276_abnormal_autonomic_nervous0.92458210
70MP0005636_abnormal_mineral_homeostasis0.87783307
71MP0004145_abnormal_muscle_electrophysio0.86888790
72MP0002282_abnormal_trachea_morphology0.85992289
73MP0002148_abnormal_hypersensitivity_rea0.85867403
74MP0002095_abnormal_skin_pigmentation0.85857716
75MP0001963_abnormal_hearing_physiology0.85733882
76MP0005195_abnormal_posterior_eye0.85330445
77MP0000026_abnormal_inner_ear0.85131974
78MP0001919_abnormal_reproductive_system0.84518550
79MP0001501_abnormal_sleep_pattern0.84393830
80MP0002210_abnormal_sex_determination0.84010895
81MP0004742_abnormal_vestibular_system0.83617814
82MP0003077_abnormal_cell_cycle0.81678757
83MP0003119_abnormal_digestive_system0.79998316
84MP0003880_abnormal_central_pattern0.79991432
85MP0001929_abnormal_gametogenesis0.79972723
86MP0009745_abnormal_behavioral_response0.73751544
87MP0001486_abnormal_startle_reflex0.73047401
88MP0002163_abnormal_gland_morphology0.72330375
89MP0003937_abnormal_limbs/digits/tail_de0.71689859
90MP0008775_abnormal_heart_ventricle0.71551629
91MP0008057_abnormal_DNA_replication0.71060290
92MP0002735_abnormal_chemical_nociception0.70388649
93MP0001286_abnormal_eye_development0.69539636
94MP0009764_decreased_sensitivity_to0.69069594
95MP0002876_abnormal_thyroid_physiology0.68329983
96MP0000685_abnormal_immune_system0.68214133
97MP0002733_abnormal_thermal_nociception0.67827216
98MP0001119_abnormal_female_reproductive0.66975190
99MP0002752_abnormal_somatic_nervous0.66969954
100MP0001145_abnormal_male_reproductive0.66941778

Predicted human phenotypes

RankGene SetZ-score
1Mitochondrial inheritance (HP:0001427)4.06203586
2Acute necrotizing encephalopathy (HP:0006965)4.04357610
33-Methylglutaconic aciduria (HP:0003535)3.92892034
4Increased CSF lactate (HP:0002490)3.82053634
5Acute encephalopathy (HP:0006846)3.76599694
6Hepatocellular necrosis (HP:0001404)3.70501684
7Abnormal mitochondria in muscle tissue (HP:0008316)3.47520428
8Increased hepatocellular lipid droplets (HP:0006565)3.41822267
9Methylmalonic acidemia (HP:0002912)3.40174600
10Hepatic necrosis (HP:0002605)3.24013404
11Progressive macrocephaly (HP:0004481)3.22358150
12Lipid accumulation in hepatocytes (HP:0006561)3.03443703
13Pancreatic cysts (HP:0001737)2.98973129
14Cerebral edema (HP:0002181)2.93624463
15Reticulocytopenia (HP:0001896)2.85950696
16Pancreatic fibrosis (HP:0100732)2.77662930
17Pancytopenia (HP:0001876)2.76575937
18Aplastic anemia (HP:0001915)2.75179497
19Methylmalonic aciduria (HP:0012120)2.65891218
20Type I transferrin isoform profile (HP:0003642)2.59198517
21Renal Fanconi syndrome (HP:0001994)2.55191462
22Macrocytic anemia (HP:0001972)2.52030382
23Aplasia/Hypoplasia of the uvula (HP:0010293)2.48486435
24Optic disc pallor (HP:0000543)2.48459233
25True hermaphroditism (HP:0010459)2.46816450
26Increased serum lactate (HP:0002151)2.44552992
27Hypoproteinemia (HP:0003075)2.43168680
28B lymphocytopenia (HP:0010976)2.35294139
29Septo-optic dysplasia (HP:0100842)2.35214678
30Molar tooth sign on MRI (HP:0002419)2.33999017
31Abnormality of midbrain morphology (HP:0002418)2.33999017
32IgG deficiency (HP:0004315)2.33913121
33Abnormal number of erythroid precursors (HP:0012131)2.32626564
34Lactic acidosis (HP:0003128)2.31693626
35Abnormality of cells of the erythroid lineage (HP:0012130)2.27700296
36Abnormal protein glycosylation (HP:0012346)2.26952538
37Abnormal glycosylation (HP:0012345)2.26952538
38Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.26952538
39Abnormal protein N-linked glycosylation (HP:0012347)2.26952538
40Abnormality of B cell number (HP:0010975)2.25821343
41Hyperglycinemia (HP:0002154)2.24804788
42Colon cancer (HP:0003003)2.23651876
43Congenital, generalized hypertrichosis (HP:0004540)2.22801344
44Testicular atrophy (HP:0000029)2.19914129
45Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.19641206
46Pendular nystagmus (HP:0012043)2.19201113
47Type 2 muscle fiber atrophy (HP:0003554)2.18447122
48Exertional dyspnea (HP:0002875)2.18238724
49Abolished electroretinogram (ERG) (HP:0000550)2.17833889
50Hyperalaninemia (HP:0003348)2.15895335
51Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.15895335
52Abnormality of alanine metabolism (HP:0010916)2.15895335
53Congenital stationary night blindness (HP:0007642)2.14326732
54Abnormality of the renal collecting system (HP:0004742)2.13496345
55Renal cortical cysts (HP:0000803)2.13028880
56CNS demyelination (HP:0007305)2.12977488
57Attenuation of retinal blood vessels (HP:0007843)2.11264040
58Abnormality of dicarboxylic acid metabolism (HP:0010995)2.10847469
59Dicarboxylic aciduria (HP:0003215)2.10847469
60Lethargy (HP:0001254)2.08973490
61Abnormality of the labia minora (HP:0012880)2.06449582
62Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.05507900
63Bilateral microphthalmos (HP:0007633)2.04306738
64Aplasia/Hypoplasia of the spleen (HP:0010451)2.04292566
65Duplicated collecting system (HP:0000081)2.00494988
66Abnormality of the renal cortex (HP:0011035)1.99162899
67Respiratory failure (HP:0002878)1.98996635
68Abnormality of the phalanges of the 5th finger (HP:0004213)1.98367028
69Abnormality of the vitamin B12 metabolism (HP:0004341)1.98089018
70Nephronophthisis (HP:0000090)1.97155539
71Abnormality of the ileum (HP:0001549)1.96599519
72Sclerocornea (HP:0000647)1.95545123
73Large eyes (HP:0001090)1.95497525
74Anophthalmia (HP:0000528)1.95371593
75Asplenia (HP:0001746)1.94944738
76Chronic hepatic failure (HP:0100626)1.93910705
77Meckel diverticulum (HP:0002245)1.93589916
78Emotional lability (HP:0000712)1.93354119
79Absent rod-and cone-mediated responses on ERG (HP:0007688)1.92486120
80Increased intramyocellular lipid droplets (HP:0012240)1.90631753
81Abnormality of the prostate (HP:0008775)1.90176737
82Abnormal respiratory motile cilium physiology (HP:0012261)1.89479653
83Small intestinal stenosis (HP:0012848)1.89354285
84Duodenal stenosis (HP:0100867)1.89354285
85Absent thumb (HP:0009777)1.88556065
86Muscle fiber atrophy (HP:0100295)1.87521930
87Supernumerary spleens (HP:0009799)1.84151817
88Abnormality of vitamin B metabolism (HP:0004340)1.82968115
89Stomatitis (HP:0010280)1.82874033
90Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.81820512
91Decreased activity of mitochondrial respiratory chain (HP:0008972)1.81528671
92Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.81528671
93Leukodystrophy (HP:0002415)1.79614706
94Carpal bone hypoplasia (HP:0001498)1.78783042
95Constricted visual fields (HP:0001133)1.78742658
96Microvesicular hepatic steatosis (HP:0001414)1.77972838
97Autoimmune hemolytic anemia (HP:0001890)1.77659176
98Pallor (HP:0000980)1.77196431
99Abnormality of the pons (HP:0007361)1.75183373
100Reduced antithrombin III activity (HP:0001976)1.74968252

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK4.13906581
2BCKDK3.89454049
3VRK23.48589853
4BUB13.08255801
5TLK13.07617740
6MAP4K22.98023864
7ADRBK22.56494746
8TXK2.46779148
9STK162.46130013
10VRK12.26313208
11WNK32.17688302
12MKNK12.14266770
13TIE12.08011716
14MST41.97169581
15GRK11.91247957
16BMPR1B1.79050639
17TSSK61.73922717
18NUAK11.71669213
19TAOK31.67136374
20WNK41.51935234
21DYRK21.42984199
22NEK11.34081515
23NME11.33587081
24PINK11.32172584
25PLK31.29533886
26PASK1.22484425
27OXSR11.20666283
28SRPK11.19628022
29EIF2AK31.18276313
30TNIK1.09676728
31ACVR1B1.08621534
32PBK1.02205884
33KIT1.02153480
34TGFBR11.00272864
35TEC0.99842537
36KDR0.96123302
37CDK190.94749035
38CDC70.94284537
39CSNK1G30.90308413
40FLT30.87443004
41STK390.84402732
42ITK0.82886939
43WEE10.82282192
44EPHA40.81644134
45PLK10.79961202
46IKBKE0.79618444
47CSNK1G10.78624280
48AURKB0.78381020
49RPS6KA50.77405549
50RPS6KA40.77284508
51INSRR0.75520806
52TRIM280.75423527
53MKNK20.74457943
54FRK0.74103478
55MAP4K10.74023714
56DYRK30.73734830
57PLK40.73411574
58TTK0.72384652
59CSNK1G20.72307150
60IKBKB0.71696892
61PDK20.71294755
62CHEK20.71209382
63ATR0.70196341
64CSNK1A10.67258125
65TESK20.67103858
66MAPK130.66367670
67TAF10.64981730
68CSNK1A1L0.63337238
69ADRBK10.62502890
70MAP3K120.60671330
71CSNK2A10.60236301
72BRSK20.58916697
73ERBB30.56730914
74CSNK2A20.56281820
75PHKG10.55344769
76PHKG20.55344769
77PKN10.54904665
78MYLK0.54061002
79BCR0.53789543
80OBSCN0.53757789
81DAPK10.51659741
82DAPK20.51647334
83EIF2AK20.51547549
84NME20.51448657
85GRK70.50471518
86EIF2AK10.47910078
87STK40.47551511
88PRKCG0.45513873
89SYK0.45325464
90DAPK30.41244473
91PRKACA0.38324962
92AURKA0.37985886
93PIK3CG0.37328963
94PIM10.37145084
95MAPKAPK50.36030654
96GRK60.35930277
97NTRK20.34869285
98EPHB20.34713963
99BTK0.34008906
100PRKCA0.32591506

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.18162098
2Ribosome_Homo sapiens_hsa030103.77213457
3Oxidative phosphorylation_Homo sapiens_hsa001903.66570559
4Parkinsons disease_Homo sapiens_hsa050123.14342883
5Protein export_Homo sapiens_hsa030602.70327194
6RNA polymerase_Homo sapiens_hsa030202.57269354
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.49519239
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.47133470
9Homologous recombination_Homo sapiens_hsa034402.22635884
10Huntingtons disease_Homo sapiens_hsa050162.13539828
11DNA replication_Homo sapiens_hsa030302.10067632
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.09673857
13Mismatch repair_Homo sapiens_hsa034302.09023247
14Alzheimers disease_Homo sapiens_hsa050101.98915420
15Spliceosome_Homo sapiens_hsa030401.96430368
16Base excision repair_Homo sapiens_hsa034101.90538296
17One carbon pool by folate_Homo sapiens_hsa006701.89549556
18Propanoate metabolism_Homo sapiens_hsa006401.74369978
19Fanconi anemia pathway_Homo sapiens_hsa034601.64809637
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.61907471
21Asthma_Homo sapiens_hsa053101.61832452
22RNA degradation_Homo sapiens_hsa030181.61181156
23Nucleotide excision repair_Homo sapiens_hsa034201.57778659
24Allograft rejection_Homo sapiens_hsa053301.52581513
25Primary immunodeficiency_Homo sapiens_hsa053401.49564949
26RNA transport_Homo sapiens_hsa030131.48846297
27Autoimmune thyroid disease_Homo sapiens_hsa053201.48037498
28Basal transcription factors_Homo sapiens_hsa030221.47493906
29Cardiac muscle contraction_Homo sapiens_hsa042601.44431353
30Pyrimidine metabolism_Homo sapiens_hsa002401.39920862
31Type I diabetes mellitus_Homo sapiens_hsa049401.26333917
32Purine metabolism_Homo sapiens_hsa002301.24798269
33Graft-versus-host disease_Homo sapiens_hsa053321.22656997
34Intestinal immune network for IgA production_Homo sapiens_hsa046721.22128175
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21198042
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.19652599
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.12828631
38Tryptophan metabolism_Homo sapiens_hsa003801.12005344
39Phototransduction_Homo sapiens_hsa047441.11376791
40Linoleic acid metabolism_Homo sapiens_hsa005911.10433856
41Butanoate metabolism_Homo sapiens_hsa006501.08639549
42Selenocompound metabolism_Homo sapiens_hsa004501.04135368
43Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.99843495
44Peroxisome_Homo sapiens_hsa041460.95122138
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.93514421
46Sulfur metabolism_Homo sapiens_hsa009200.92786626
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90182673
48Maturity onset diabetes of the young_Homo sapiens_hsa049500.89894815
49Nitrogen metabolism_Homo sapiens_hsa009100.76811381
50Antigen processing and presentation_Homo sapiens_hsa046120.75134625
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74412979
52Retinol metabolism_Homo sapiens_hsa008300.74382206
53Steroid biosynthesis_Homo sapiens_hsa001000.74367575
54Histidine metabolism_Homo sapiens_hsa003400.74101994
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.73304609
56Metabolic pathways_Homo sapiens_hsa011000.72382770
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71650897
58Systemic lupus erythematosus_Homo sapiens_hsa053220.69399804
59beta-Alanine metabolism_Homo sapiens_hsa004100.67596732
60Rheumatoid arthritis_Homo sapiens_hsa053230.67146767
61Chemical carcinogenesis_Homo sapiens_hsa052040.65777433
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.65661453
63Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.60978401
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60098851
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.59048134
66Taste transduction_Homo sapiens_hsa047420.58439203
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.57574663
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57089525
69Caffeine metabolism_Homo sapiens_hsa002320.56104539
70Non-homologous end-joining_Homo sapiens_hsa034500.55852151
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55690886
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.54212557
73Glutathione metabolism_Homo sapiens_hsa004800.54010810
74Arachidonic acid metabolism_Homo sapiens_hsa005900.51815667
75Nicotine addiction_Homo sapiens_hsa050330.50434981
76Fatty acid elongation_Homo sapiens_hsa000620.49959119
77Pyruvate metabolism_Homo sapiens_hsa006200.49917056
78Olfactory transduction_Homo sapiens_hsa047400.49469599
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49014218
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48957616
81Ether lipid metabolism_Homo sapiens_hsa005650.47632328
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47588486
83Hematopoietic cell lineage_Homo sapiens_hsa046400.47070510
84Fat digestion and absorption_Homo sapiens_hsa049750.46943079
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.46419918
86Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44150015
87Vitamin digestion and absorption_Homo sapiens_hsa049770.41475757
88Cell cycle_Homo sapiens_hsa041100.40108822
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35155380
90mRNA surveillance pathway_Homo sapiens_hsa030150.33023699
91Fatty acid degradation_Homo sapiens_hsa000710.32954226
92Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.32608926
93p53 signaling pathway_Homo sapiens_hsa041150.32083153
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.31091928
95Regulation of autophagy_Homo sapiens_hsa041400.27765997
96Epstein-Barr virus infection_Homo sapiens_hsa051690.26079085
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.25476242
98Oocyte meiosis_Homo sapiens_hsa041140.24299716
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24061313
100Hedgehog signaling pathway_Homo sapiens_hsa043400.23787495

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