HNRNPA1P30

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)5.79169804
2regulation of isotype switching to IgG isotypes (GO:0048302)4.83532154
3base-excision repair, AP site formation (GO:0006285)4.69715666
4DNA deamination (GO:0045006)4.57024964
5L-fucose catabolic process (GO:0042355)4.52196208
6fucose catabolic process (GO:0019317)4.52196208
7L-fucose metabolic process (GO:0042354)4.52196208
8rRNA catabolic process (GO:0016075)4.23188788
9mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.22900364
10mitochondrial respiratory chain complex I assembly (GO:0032981)4.22900364
11NADH dehydrogenase complex assembly (GO:0010257)4.22900364
12DNA catabolic process, exonucleolytic (GO:0000738)4.04439892
13protein complex biogenesis (GO:0070271)3.97463382
14mitochondrial respiratory chain complex assembly (GO:0033108)3.96875454
15regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.94944455
16respiratory chain complex IV assembly (GO:0008535)3.92435564
17establishment of protein localization to mitochondrial membrane (GO:0090151)3.92391669
18water-soluble vitamin biosynthetic process (GO:0042364)3.89851897
19maturation of 5.8S rRNA (GO:0000460)3.83892008
20vitamin transmembrane transport (GO:0035461)3.75490546
21rRNA modification (GO:0000154)3.72730067
22negative regulation of DNA-dependent DNA replication (GO:2000104)3.69686417
23regulation of podosome assembly (GO:0071801)3.58788254
24rRNA methylation (GO:0031167)3.41355655
25cullin deneddylation (GO:0010388)3.40762450
26cellular ketone body metabolic process (GO:0046950)3.39582321
27cytochrome complex assembly (GO:0017004)3.37525214
28exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.36515407
29ribosomal small subunit assembly (GO:0000028)3.35329888
30DNA double-strand break processing (GO:0000729)3.35194867
31chaperone-mediated protein transport (GO:0072321)3.31727766
32negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.28280673
33nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.27276251
34DNA damage response, detection of DNA damage (GO:0042769)3.26016037
35regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.25841653
36regulation of cellular amino acid metabolic process (GO:0006521)3.16390307
37DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.14884398
38proteasome assembly (GO:0043248)3.14391593
39regulation of memory T cell differentiation (GO:0043380)3.12352999
40signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.09854488
41signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.09854488
42signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.09854488
43protein deneddylation (GO:0000338)3.08427354
44aldehyde catabolic process (GO:0046185)3.07209504
45signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.05101655
46intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.05101655
47protein K6-linked ubiquitination (GO:0085020)3.05088597
48positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.04891666
49DNA replication checkpoint (GO:0000076)3.03276659
50positive regulation of chemokine biosynthetic process (GO:0045080)3.01954226
51fucosylation (GO:0036065)3.01154167
52ubiquinone biosynthetic process (GO:0006744)2.99722210
53intracellular protein transmembrane import (GO:0044743)2.98844404
54pyrimidine-containing compound transmembrane transport (GO:0072531)2.98801332
55ketone body metabolic process (GO:1902224)2.97812698
56signal transduction involved in cell cycle checkpoint (GO:0072395)2.95932635
57signal transduction involved in DNA integrity checkpoint (GO:0072401)2.93353096
58signal transduction involved in DNA damage checkpoint (GO:0072422)2.93353096
59negative regulation of ligase activity (GO:0051352)2.93055777
60negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.93055777
61regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.92165764
62ribosomal large subunit biogenesis (GO:0042273)2.90270519
63regulation of nuclear cell cycle DNA replication (GO:0033262)2.89828699
64signal peptide processing (GO:0006465)2.88601870
65behavioral response to nicotine (GO:0035095)2.88085475
66tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.87761330
67RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.87761330
68IMP biosynthetic process (GO:0006188)2.86690594
69rRNA metabolic process (GO:0016072)2.85671413
70positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.82892112
71mitochondrial RNA metabolic process (GO:0000959)2.82696085
72rRNA processing (GO:0006364)2.82070477
73pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.78961258
74transcription elongation from RNA polymerase III promoter (GO:0006385)2.78072450
75termination of RNA polymerase III transcription (GO:0006386)2.78072450
76protein neddylation (GO:0045116)2.77682744
77replication fork processing (GO:0031297)2.77550705
78folic acid-containing compound biosynthetic process (GO:0009396)2.77433018
79maturation of SSU-rRNA (GO:0030490)2.76791195
80spliceosomal snRNP assembly (GO:0000387)2.75377511
81DNA replication-dependent nucleosome organization (GO:0034723)2.74952678
82DNA replication-dependent nucleosome assembly (GO:0006335)2.74952678
83ncRNA catabolic process (GO:0034661)2.74039540
84negative regulation of thymocyte apoptotic process (GO:0070244)2.73394697
85anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.73377278
86regulation of interleukin-12 biosynthetic process (GO:0045075)2.73237282
87histone-serine phosphorylation (GO:0035404)2.72870923
88energy coupled proton transport, down electrochemical gradient (GO:0015985)2.72500904
89ATP synthesis coupled proton transport (GO:0015986)2.72500904
90regulation of chronic inflammatory response (GO:0002676)2.72464594
91positive regulation of isotype switching (GO:0045830)2.69174154
92positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.68850771
93spliceosomal complex assembly (GO:0000245)2.67658757
94maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.66953081
95regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.64918619
96quinone biosynthetic process (GO:1901663)2.64312200
97regulation of MHC class II biosynthetic process (GO:0045346)2.63969983
98chromatin remodeling at centromere (GO:0031055)2.62350121
99ubiquinone metabolic process (GO:0006743)2.61271805
100protein-cofactor linkage (GO:0018065)2.60731314

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.78952853
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.38167820
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.00343068
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.77232522
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.63263236
6ZNF274_21170338_ChIP-Seq_K562_Hela3.41442304
7VDR_22108803_ChIP-Seq_LS180_Human3.25756286
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.10796404
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.79410665
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.64039147
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.53224161
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.52371612
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.47883555
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.41833960
15NOTCH1_21737748_ChIP-Seq_TLL_Human2.33769860
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.32201075
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.28234110
18VDR_23849224_ChIP-Seq_CD4+_Human2.11673360
19MYC_18555785_ChIP-Seq_MESCs_Mouse2.11604831
20EZH2_22144423_ChIP-Seq_EOC_Human2.08370273
21ELK1_19687146_ChIP-ChIP_HELA_Human1.96860308
22SRF_21415370_ChIP-Seq_HL-1_Mouse1.87676149
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.86517675
24E2F7_22180533_ChIP-Seq_HELA_Human1.86139332
25EWS_26573619_Chip-Seq_HEK293_Human1.84383277
26CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.79100854
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.77980822
28FOXP3_21729870_ChIP-Seq_TREG_Human1.75598135
29MYC_18940864_ChIP-ChIP_HL60_Human1.74027427
30EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.67728221
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.61013112
32TP53_22573176_ChIP-Seq_HFKS_Human1.51499160
33FUS_26573619_Chip-Seq_HEK293_Human1.47434646
34PCGF2_27294783_Chip-Seq_NPCs_Mouse1.45616896
35MYC_18358816_ChIP-ChIP_MESCs_Mouse1.40811672
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38770029
37MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.36969668
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.35943486
39PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.35380431
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.33273991
41TTF2_22483619_ChIP-Seq_HELA_Human1.32340141
42IRF1_19129219_ChIP-ChIP_H3396_Human1.31583344
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.28364482
44XRN2_22483619_ChIP-Seq_HELA_Human1.28147960
45NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.25261784
46FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23344629
47FOXA1_25329375_ChIP-Seq_VCAP_Human1.23344629
48GABP_19822575_ChIP-Seq_HepG2_Human1.22654484
49CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.20719837
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.20623517
51PADI4_21655091_ChIP-ChIP_MCF-7_Human1.19357810
52LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17899998
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.17725083
54MYC_19030024_ChIP-ChIP_MESCs_Mouse1.17361851
55P300_19829295_ChIP-Seq_ESCs_Human1.17118088
56GATA1_22025678_ChIP-Seq_K562_Human1.16611176
57POU5F1_16153702_ChIP-ChIP_HESCs_Human1.15879555
58SOX2_19829295_ChIP-Seq_ESCs_Human1.15163273
59NANOG_19829295_ChIP-Seq_ESCs_Human1.15163273
60THAP11_20581084_ChIP-Seq_MESCs_Mouse1.12416233
61DCP1A_22483619_ChIP-Seq_HELA_Human1.11372085
62MYC_19079543_ChIP-ChIP_MESCs_Mouse1.09065790
63HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.07536458
64NFE2_27457419_Chip-Seq_LIVER_Mouse1.07413087
65GBX2_23144817_ChIP-Seq_PC3_Human1.06903159
66UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06245679
67EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04936294
68NANOG_20526341_ChIP-Seq_ESCs_Human1.04890793
69IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.04749682
70FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.04239961
71ELK1_22589737_ChIP-Seq_MCF10A_Human1.03780394
72GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02848501
73GATA3_21878914_ChIP-Seq_MCF-7_Human1.02749784
74MYC_19829295_ChIP-Seq_ESCs_Human1.02317940
75SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99713998
76CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99394914
77TAF2_19829295_ChIP-Seq_ESCs_Human0.99112594
78HOXB7_26014856_ChIP-Seq_BT474_Human0.98155729
79RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97386862
80EZH2_27294783_Chip-Seq_NPCs_Mouse0.95191319
81ER_23166858_ChIP-Seq_MCF-7_Human0.94777634
82POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94567202
83FOXA1_21572438_ChIP-Seq_LNCaP_Human0.91915754
84BCAT_22108803_ChIP-Seq_LS180_Human0.91475366
85EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.91259666
86E2F1_18555785_ChIP-Seq_MESCs_Mouse0.91041975
87KLF5_20875108_ChIP-Seq_MESCs_Mouse0.90091481
88AR_20517297_ChIP-Seq_VCAP_Human0.89641041
89EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.88901084
90ERG_20517297_ChIP-Seq_VCAP_Human0.88074692
91GATA3_26560356_Chip-Seq_TH2_Human0.86645164
92CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.86518106
93RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.85494054
94FOXH1_21741376_ChIP-Seq_EPCs_Human0.85207984
95PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.84731492
96ERA_21632823_ChIP-Seq_H3396_Human0.84659264
97ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.81519490
98IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.79935492
99SALL4_22934838_ChIP-ChIP_CD34+_Human0.79625743
100ETV2_25802403_ChIP-Seq_MESCs_Mouse0.79284023

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.55360196
2MP0008875_abnormal_xenobiotic_pharmacok3.19510036
3MP0003195_calcinosis3.10519071
4MP0004147_increased_porphyrin_level3.01001214
5MP0003693_abnormal_embryo_hatching2.98633150
6MP0001873_stomach_inflammation2.98026655
7MP0009379_abnormal_foot_pigmentation2.66689868
8MP0002102_abnormal_ear_morphology2.64504765
9MP0008872_abnormal_physiological_respon2.50783208
10MP0008058_abnormal_DNA_repair2.48162022
11MP0005671_abnormal_response_to2.30169992
12MP0003718_maternal_effect2.21365605
13MP0001835_abnormal_antigen_presentation2.17953916
14MP0002736_abnormal_nociception_after2.00851386
15MP0004885_abnormal_endolymph1.98174873
16MP0000685_abnormal_immune_system1.93096636
17MP0001348_abnormal_lacrimal_gland1.87357598
18MP0010094_abnormal_chromosome_stability1.86063486
19MP0004742_abnormal_vestibular_system1.86041119
20MP0006072_abnormal_retinal_apoptosis1.74993339
21MP0003950_abnormal_plasma_membrane1.73792549
22MP0002653_abnormal_ependyma_morphology1.70762047
23MP0000372_irregular_coat_pigmentation1.68355485
24MP0001986_abnormal_taste_sensitivity1.63348812
25MP0009333_abnormal_splenocyte_physiolog1.59824725
26MP0003136_yellow_coat_color1.59008530
27MP0004782_abnormal_surfactant_physiolog1.57738628
28MP0003186_abnormal_redox_activity1.56640181
29MP0005645_abnormal_hypothalamus_physiol1.54993446
30MP0004957_abnormal_blastocyst_morpholog1.51478997
31MP0001968_abnormal_touch/_nociception1.42684513
32MP0005387_immune_system_phenotype1.42553207
33MP0001790_abnormal_immune_system1.42553207
34MP0006292_abnormal_olfactory_placode1.42505883
35MP0003646_muscle_fatigue1.39411456
36MP0006036_abnormal_mitochondrial_physio1.38122114
37MP0008789_abnormal_olfactory_epithelium1.37041060
38MP0005551_abnormal_eye_electrophysiolog1.36599837
39MP0004145_abnormal_muscle_electrophysio1.34931079
40MP0003806_abnormal_nucleotide_metabolis1.34264216
41MP0009785_altered_susceptibility_to1.32943645
42MP0002148_abnormal_hypersensitivity_rea1.32346490
43MP0009745_abnormal_behavioral_response1.31123668
44MP0002163_abnormal_gland_morphology1.30247739
45MP0000569_abnormal_digit_pigmentation1.25490461
46MP0005085_abnormal_gallbladder_physiolo1.22112445
47MP0001800_abnormal_humoral_immune1.20945734
48MP0005365_abnormal_bile_salt1.19921535
49MP0003878_abnormal_ear_physiology1.18927268
50MP0005377_hearing/vestibular/ear_phenot1.18927268
51MP0009765_abnormal_xenobiotic_induced1.17920888
52MP0001984_abnormal_olfaction1.17612847
53MP0005084_abnormal_gallbladder_morpholo1.17178222
54MP0005310_abnormal_salivary_gland1.16894746
55MP0001485_abnormal_pinna_reflex1.03607854
56MP0005360_urolithiasis1.01182781
57MP0002272_abnormal_nervous_system0.99613760
58MP0002822_catalepsy0.98126263
59MP0002160_abnormal_reproductive_system0.97845065
60MP0001529_abnormal_vocalization0.97306855
61MP0005379_endocrine/exocrine_gland_phen0.96866831
62MP0009764_decreased_sensitivity_to0.96672628
63MP0005389_reproductive_system_phenotype0.96296354
64MP0002210_abnormal_sex_determination0.93187435
65MP0005174_abnormal_tail_pigmentation0.88968389
66MP0002277_abnormal_respiratory_mucosa0.87908923
67MP0008057_abnormal_DNA_replication0.87797204
68MP0005000_abnormal_immune_tolerance0.86067764
69MP0000383_abnormal_hair_follicle0.84843492
70MP0003786_premature_aging0.83970525
71MP0001501_abnormal_sleep_pattern0.83499928
72MP0001119_abnormal_female_reproductive0.83468728
73MP0001905_abnormal_dopamine_level0.82797310
74MP0002064_seizures0.81077242
75MP0000427_abnormal_hair_cycle0.76573477
76MP0003567_abnormal_fetal_cardiomyocyte0.76350298
77MP0002733_abnormal_thermal_nociception0.76016536
78MP0001929_abnormal_gametogenesis0.75475720
79MP0003111_abnormal_nucleus_morphology0.75020313
80MP0002138_abnormal_hepatobiliary_system0.74716647
81MP0005253_abnormal_eye_physiology0.74221786
82MP0005395_other_phenotype0.73919382
83MP0004215_abnormal_myocardial_fiber0.73506070
84MP0002723_abnormal_immune_serum0.72895810
85MP0003880_abnormal_central_pattern0.72238058
86MP0003329_amyloid_beta_deposits0.71801410
87MP0003077_abnormal_cell_cycle0.71140626
88MP0005636_abnormal_mineral_homeostasis0.70802135
89MP0002405_respiratory_system_inflammati0.70002215
90MP0001663_abnormal_digestive_system0.69567205
91MP0002638_abnormal_pupillary_reflex0.69094245
92MP0003119_abnormal_digestive_system0.68649612
93MP0008995_early_reproductive_senescence0.68639860
94MP0005499_abnormal_olfactory_system0.68454077
95MP0005394_taste/olfaction_phenotype0.68454077
96MP0004133_heterotaxia0.68446293
97MP0010155_abnormal_intestine_physiology0.65931332
98MP0005075_abnormal_melanosome_morpholog0.65187694
99MP0004142_abnormal_muscle_tone0.65057078
100MP0005319_abnormal_enzyme/_coenzyme0.63749788

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the pons (HP:0007361)4.17695602
2Duplicated collecting system (HP:0000081)3.98098664
3Acute necrotizing encephalopathy (HP:0006965)3.77898303
4Abnormality of the renal collecting system (HP:0004742)3.65828089
5Increased CSF lactate (HP:0002490)3.58646926
6Large for gestational age (HP:0001520)3.50211435
7Mitochondrial inheritance (HP:0001427)3.48716698
8Hepatocellular necrosis (HP:0001404)3.40076798
9Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.33016546
10Abnormality of alanine metabolism (HP:0010916)3.33016546
11Hyperalaninemia (HP:0003348)3.33016546
12Colon cancer (HP:0003003)3.31218615
13Inability to walk (HP:0002540)3.30380961
14Hepatic necrosis (HP:0002605)3.27448439
15Cerebral hypomyelination (HP:0006808)3.26490223
16Abnormal mitochondria in muscle tissue (HP:0008316)3.25253942
17Acute encephalopathy (HP:0006846)3.12024534
18Concave nail (HP:0001598)3.10501866
19Hypoplasia of the pons (HP:0012110)3.09367278
203-Methylglutaconic aciduria (HP:0003535)3.08708248
21Abnormality of the labia minora (HP:0012880)3.03076799
22Molar tooth sign on MRI (HP:0002419)3.02673623
23Abnormality of midbrain morphology (HP:0002418)3.02673623
24Progressive macrocephaly (HP:0004481)3.01963896
25IgG deficiency (HP:0004315)2.87073687
26Increased serum lactate (HP:0002151)2.86484919
27Pancreatic cysts (HP:0001737)2.80052448
28Increased hepatocellular lipid droplets (HP:0006565)2.77613019
29Abnormal number of erythroid precursors (HP:0012131)2.76774819
30Birth length less than 3rd percentile (HP:0003561)2.76462176
31Reticulocytopenia (HP:0001896)2.73003178
32Abnormal respiratory motile cilium morphology (HP:0005938)2.63239928
33Abnormal respiratory epithelium morphology (HP:0012253)2.63239928
34Increased serum pyruvate (HP:0003542)2.60914624
35Lipid accumulation in hepatocytes (HP:0006561)2.58197044
36Congenital, generalized hypertrichosis (HP:0004540)2.52436633
37Conical tooth (HP:0000698)2.47986829
38Abnormality of cells of the erythroid lineage (HP:0012130)2.47157456
39IgA deficiency (HP:0002720)2.46660798
40Confusion (HP:0001289)2.44357068
41Pendular nystagmus (HP:0012043)2.43343385
42Nephronophthisis (HP:0000090)2.41487797
43Cerebral edema (HP:0002181)2.40813967
44Aplasia/Hypoplasia of the uvula (HP:0010293)2.39595627
45Abnormality of glycolysis (HP:0004366)2.33181641
46Optic disc pallor (HP:0000543)2.28379567
47IgM deficiency (HP:0002850)2.25773778
48Opisthotonus (HP:0002179)2.23638272
49Congenital stationary night blindness (HP:0007642)2.22690172
50Lactic acidosis (HP:0003128)2.20524511
51Absent thumb (HP:0009777)2.17319806
52True hermaphroditism (HP:0010459)2.16629797
53Ureteral duplication (HP:0000073)2.16251333
54Patellar aplasia (HP:0006443)2.12969459
55Mutism (HP:0002300)2.10814037
56Pancreatic fibrosis (HP:0100732)2.10628101
57Respiratory difficulties (HP:0002880)2.09765335
58Hypothermia (HP:0002045)2.09619018
59Dynein arm defect of respiratory motile cilia (HP:0012255)2.08854359
60Absent/shortened dynein arms (HP:0200106)2.08854359
61Aplasia/Hypoplasia of the patella (HP:0006498)2.08659626
62CNS demyelination (HP:0007305)2.06203595
63Lethargy (HP:0001254)2.06194025
64Stomach cancer (HP:0012126)2.05527123
65Meckel diverticulum (HP:0002245)2.03863612
66Abnormality of the ileum (HP:0001549)2.03079853
67Partial agenesis of the corpus callosum (HP:0001338)2.02732595
68Chromosomal breakage induced by crosslinking agents (HP:0003221)2.01788547
69Hyperglycinuria (HP:0003108)2.00011449
70Abnormality of the renal cortex (HP:0011035)1.95385222
71Renal cortical cysts (HP:0000803)1.94347597
72Aplasia/Hypoplasia involving the musculature (HP:0001460)1.92471136
73Abnormality of T cell physiology (HP:0011840)1.92131384
74CNS hypomyelination (HP:0003429)1.91482825
75Decreased circulating renin level (HP:0003351)1.90348746
76Methylmalonic aciduria (HP:0012120)1.86629466
77Decreased central vision (HP:0007663)1.86374826
78Abnormality of the preputium (HP:0100587)1.84524357
79Abnormal albumin level (HP:0012116)1.84265869
80Hypoalbuminemia (HP:0003073)1.84265869
81Supernumerary spleens (HP:0009799)1.83830936
82Generalized aminoaciduria (HP:0002909)1.83685096
83Abnormality of T cells (HP:0002843)1.83120959
84Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.82472472
85Decreased activity of mitochondrial respiratory chain (HP:0008972)1.82472472
86Bile duct proliferation (HP:0001408)1.82432326
87Abnormal biliary tract physiology (HP:0012439)1.82432326
88Respiratory failure (HP:0002878)1.81155365
89Exercise intolerance (HP:0003546)1.80786401
90Type II lissencephaly (HP:0007260)1.80636424
91Clubbing of toes (HP:0100760)1.79888863
92Renal Fanconi syndrome (HP:0001994)1.78941071
93Increased intramyocellular lipid droplets (HP:0012240)1.78479334
94Palpebral edema (HP:0100540)1.78312433
95Abnormality of the renal medulla (HP:0100957)1.78243689
96Furrowed tongue (HP:0000221)1.78229885
97Chromsome breakage (HP:0040012)1.78192948
98Morphological abnormality of the inner ear (HP:0011390)1.77218439
99Bronchiectasis (HP:0002110)1.75934528
100Azoospermia (HP:0000027)1.72377280

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.70430148
2TSSK63.61835445
3ADRBK23.54226882
4ZAK3.53425270
5PBK3.14452924
6TLK12.97133730
7BUB12.93238780
8EIF2AK32.77779155
9EIF2AK12.77425601
10VRK12.68517087
11TRIM282.54039682
12NUAK12.17537151
13TNIK2.07770174
14MST42.06362928
15ALK1.83423207
16NME11.80488810
17WNK31.73340282
18PASK1.70179773
19TXK1.65270749
20NEK11.63121806
21PDK21.59300288
22ACVR1B1.58561271
23PLK41.58488142
24DAPK21.58457280
25PLK31.57543614
26BMPR1B1.56309211
27MKNK11.53715943
28BCKDK1.53240762
29GRK11.46086875
30TGFBR11.40349523
31STK161.39277526
32MAP2K21.37655946
33MAP2K61.27256715
34WNK41.17563046
35DYRK21.14933701
36CCNB11.11714175
37NLK1.11105141
38MKNK21.10751252
39FRK1.08540267
40PINK11.06311791
41CAMKK21.04509833
42ADRBK10.95384704
43CDC70.90896350
44EIF2AK20.88804430
45ITK0.86691723
46IKBKB0.82559792
47MAPK130.81707924
48NEK60.81506172
49PKN10.80007768
50PNCK0.79964091
51PLK20.77823767
52MELK0.76593133
53GRK50.73723372
54BRSK20.73339124
55TIE10.73234035
56MAP2K70.69711281
57CDK80.67010767
58MAP4K20.66730485
59KDR0.65700133
60RPS6KA50.65352523
61INSRR0.64873000
62MAPKAPK30.64842415
63OXSR10.64588374
64MAP4K10.64131406
65TTK0.63297062
66PLK10.61119396
67WEE10.59941775
68PRKCQ0.58943349
69ERBB40.57715382
70CDK30.57087955
71STK40.56199395
72AURKB0.55418720
73SRPK10.54956072
74ATR0.53458662
75FLT30.52582630
76IRAK40.46954291
77FGFR10.43394687
78PHKG20.40991035
79PHKG10.40991035
80PIK3CG0.40944004
81PIK3CA0.40332116
82BRSK10.40046552
83CDK40.39773719
84PRKCI0.39075247
85MAP3K40.38334983
86CSNK2A10.37108725
87MAPKAPK50.36554526
88MAP3K50.36154331
89IKBKE0.33770898
90TAF10.32923682
91TEC0.32245483
92PIM10.32103929
93STK110.30749633
94GRK70.30208991
95BMPR20.29097242
96PRKCG0.28535998
97TAOK30.27988954
98STK390.27540799
99AURKA0.27493433
100CHUK0.26759377

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.64269023
2Ribosome_Homo sapiens_hsa030102.72347000
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.66401225
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.64010436
5Oxidative phosphorylation_Homo sapiens_hsa001902.51929078
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.42276547
7RNA polymerase_Homo sapiens_hsa030202.37672890
8One carbon pool by folate_Homo sapiens_hsa006702.28343800
9Homologous recombination_Homo sapiens_hsa034402.22828214
10Asthma_Homo sapiens_hsa053102.07470320
11Protein export_Homo sapiens_hsa030602.05374179
12Parkinsons disease_Homo sapiens_hsa050122.03155979
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.99431569
14Butanoate metabolism_Homo sapiens_hsa006501.96325426
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.93768029
16Linoleic acid metabolism_Homo sapiens_hsa005911.92506005
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.91023681
18RNA degradation_Homo sapiens_hsa030181.73717562
19Primary immunodeficiency_Homo sapiens_hsa053401.73086695
20DNA replication_Homo sapiens_hsa030301.71115420
21Allograft rejection_Homo sapiens_hsa053301.66202962
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.57149946
23Basal transcription factors_Homo sapiens_hsa030221.46621858
24Propanoate metabolism_Homo sapiens_hsa006401.43489906
25Mismatch repair_Homo sapiens_hsa034301.38634786
26Huntingtons disease_Homo sapiens_hsa050161.37664346
27Fanconi anemia pathway_Homo sapiens_hsa034601.36883752
28Selenocompound metabolism_Homo sapiens_hsa004501.35307548
29Base excision repair_Homo sapiens_hsa034101.34150042
30Vitamin B6 metabolism_Homo sapiens_hsa007501.34147745
31Non-homologous end-joining_Homo sapiens_hsa034501.33454564
32Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.30056238
33Spliceosome_Homo sapiens_hsa030401.29173455
34Nitrogen metabolism_Homo sapiens_hsa009101.24349887
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.22700621
36Autoimmune thyroid disease_Homo sapiens_hsa053201.20756977
37Primary bile acid biosynthesis_Homo sapiens_hsa001201.20444167
38RNA transport_Homo sapiens_hsa030131.19589513
39Peroxisome_Homo sapiens_hsa041461.19526249
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.18752446
41Ether lipid metabolism_Homo sapiens_hsa005651.17992860
42Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.15104218
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14642803
44Alzheimers disease_Homo sapiens_hsa050101.13086381
45Pyrimidine metabolism_Homo sapiens_hsa002401.11897035
46Vitamin digestion and absorption_Homo sapiens_hsa049771.11835239
47Nucleotide excision repair_Homo sapiens_hsa034201.10566103
48Fat digestion and absorption_Homo sapiens_hsa049751.07466162
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.03373153
50Purine metabolism_Homo sapiens_hsa002301.02182285
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.98968974
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.97599333
53Tryptophan metabolism_Homo sapiens_hsa003800.97545025
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.94168377
55Phototransduction_Homo sapiens_hsa047440.93943365
56Pyruvate metabolism_Homo sapiens_hsa006200.93811135
57Caffeine metabolism_Homo sapiens_hsa002320.92757527
58Rheumatoid arthritis_Homo sapiens_hsa053230.89247831
59Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.88871746
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85339487
61Fatty acid degradation_Homo sapiens_hsa000710.84070571
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83477412
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.81614709
64Maturity onset diabetes of the young_Homo sapiens_hsa049500.80917454
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.80460719
66Graft-versus-host disease_Homo sapiens_hsa053320.74112686
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.73699185
68Arachidonic acid metabolism_Homo sapiens_hsa005900.71498517
69Type I diabetes mellitus_Homo sapiens_hsa049400.71254509
70Retinol metabolism_Homo sapiens_hsa008300.70182664
71Collecting duct acid secretion_Homo sapiens_hsa049660.68029301
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66781559
73Cyanoamino acid metabolism_Homo sapiens_hsa004600.63940145
74Metabolic pathways_Homo sapiens_hsa011000.62396230
75Systemic lupus erythematosus_Homo sapiens_hsa053220.61817212
76Cardiac muscle contraction_Homo sapiens_hsa042600.61391673
77Nicotine addiction_Homo sapiens_hsa050330.60969176
78Hematopoietic cell lineage_Homo sapiens_hsa046400.60826003
79Chemical carcinogenesis_Homo sapiens_hsa052040.59532520
80Antigen processing and presentation_Homo sapiens_hsa046120.55329564
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55215617
82ABC transporters_Homo sapiens_hsa020100.50514879
83T cell receptor signaling pathway_Homo sapiens_hsa046600.49262919
842-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41801994
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41665109
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40753388
87Epstein-Barr virus infection_Homo sapiens_hsa051690.39771404
88Olfactory transduction_Homo sapiens_hsa047400.39031574
89Sulfur metabolism_Homo sapiens_hsa009200.38893838
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.38152150
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37633084
92Arginine and proline metabolism_Homo sapiens_hsa003300.37016264
93Starch and sucrose metabolism_Homo sapiens_hsa005000.36824192
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.36394051
95Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.35367242
96Fatty acid metabolism_Homo sapiens_hsa012120.33915592
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.33185072
98Histidine metabolism_Homo sapiens_hsa003400.33063746
99Cell cycle_Homo sapiens_hsa041100.32748763
100NF-kappa B signaling pathway_Homo sapiens_hsa040640.31533223

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