HNRNPA1P28

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of isotype switching to IgG isotypes (GO:0048302)6.82534478
2regulation of podosome assembly (GO:0071801)6.76258374
3positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)5.90352561
4positive regulation of chemokine biosynthetic process (GO:0045080)5.43663724
5CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)5.25199728
6regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)5.21492917
7regulation of immunoglobulin secretion (GO:0051023)5.07688706
8positive regulation of isotype switching (GO:0045830)4.88272436
9regulation of chronic inflammatory response (GO:0002676)4.86618482
10nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.65980855
11exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.57606165
12ATP synthesis coupled proton transport (GO:0015986)4.50200126
13energy coupled proton transport, down electrochemical gradient (GO:0015985)4.50200126
14positive regulation of DNA recombination (GO:0045911)4.47500914
15regulation of vitamin D biosynthetic process (GO:0060556)4.39161221
16mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.31907805
17regulation of chemokine biosynthetic process (GO:0045073)3.97071034
18regulation of MHC class II biosynthetic process (GO:0045346)3.93129668
19ribosomal small subunit assembly (GO:0000028)3.88921423
20positive regulation of immunoglobulin production (GO:0002639)3.88589416
21negative regulation of T-helper cell differentiation (GO:0045623)3.86382282
22negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.86382282
23negative regulation of alpha-beta T cell differentiation (GO:0046639)3.78329463
24positive regulation of organelle assembly (GO:1902117)3.76219797
25negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.74982453
26ribosomal large subunit biogenesis (GO:0042273)3.70716494
27establishment of protein localization to mitochondrial membrane (GO:0090151)3.61922851
28termination of RNA polymerase I transcription (GO:0006363)3.60881835
29DNA deamination (GO:0045006)3.60455153
30proteasome assembly (GO:0043248)3.56707270
31regulation of vitamin metabolic process (GO:0030656)3.55484987
32N-acetylglucosamine metabolic process (GO:0006044)3.50608155
33RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.45780370
34regulation of cellular amino acid metabolic process (GO:0006521)3.43629263
35positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.39967211
36microtubule depolymerization (GO:0007019)3.38704276
37DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.38206011
38water-soluble vitamin biosynthetic process (GO:0042364)3.37744004
39transcription elongation from RNA polymerase I promoter (GO:0006362)3.36710360
40alpha-beta T cell differentiation involved in immune response (GO:0002293)3.36050973
41alpha-beta T cell activation involved in immune response (GO:0002287)3.36050973
42T cell differentiation involved in immune response (GO:0002292)3.36050973
43T cell lineage commitment (GO:0002360)3.35820425
44negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.35536739
45negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.34352015
46negative regulation of ligase activity (GO:0051352)3.34352015
47regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.31671123
48signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.30656036
49signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.30656036
50signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.30656036
51intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.28650316
52signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.28650316
53cytokine production involved in immune response (GO:0002367)3.27205937
54dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.19583390
55rRNA modification (GO:0000154)3.19199378
56signal transduction involved in DNA damage checkpoint (GO:0072422)3.18156647
57signal transduction involved in DNA integrity checkpoint (GO:0072401)3.18156647
58signal transduction involved in cell cycle checkpoint (GO:0072395)3.17639680
59maturation of 5.8S rRNA (GO:0000460)3.12367797
60rRNA processing (GO:0006364)3.11947765
61anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.11409294
62GDP-mannose metabolic process (GO:0019673)3.10842631
63kinetochore assembly (GO:0051382)3.04857851
64negative regulation of acute inflammatory response (GO:0002674)3.03887460
65transcription elongation from RNA polymerase III promoter (GO:0006385)3.03754478
66termination of RNA polymerase III transcription (GO:0006386)3.03754478
67rRNA metabolic process (GO:0016072)3.03397833
68protein complex biogenesis (GO:0070271)3.02228352
69positive regulation of activated T cell proliferation (GO:0042104)3.02122658
70behavioral response to nicotine (GO:0035095)3.01091751
71SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.97469215
72somite development (GO:0061053)2.94720302
73cotranslational protein targeting to membrane (GO:0006613)2.94663525
74translation (GO:0006412)2.92799104
75neuron fate determination (GO:0048664)2.92006472
76somatic hypermutation of immunoglobulin genes (GO:0016446)2.91920479
77somatic diversification of immune receptors via somatic mutation (GO:0002566)2.91920479
78chaperone-mediated protein transport (GO:0072321)2.91111608
79mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.91052772
80mitochondrial respiratory chain complex I assembly (GO:0032981)2.91052772
81NADH dehydrogenase complex assembly (GO:0010257)2.91052772
82transcription from RNA polymerase I promoter (GO:0006360)2.90454006
83mitochondrial respiratory chain complex assembly (GO:0033108)2.90400010
84cellular ketone body metabolic process (GO:0046950)2.90004164
85viral transcription (GO:0019083)2.89138905
86rRNA methylation (GO:0031167)2.88091047
87protein targeting to ER (GO:0045047)2.86298488
88translational termination (GO:0006415)2.86250367
89regulation of proton transport (GO:0010155)2.85523824
90maturation of SSU-rRNA (GO:0030490)2.84875344
91regulation of isotype switching (GO:0045191)2.83720880
92positive regulation of granulocyte differentiation (GO:0030854)2.82442149
93spliceosomal snRNP assembly (GO:0000387)2.82016814
94innate immune response in mucosa (GO:0002227)2.80608514
95positive regulation of B cell mediated immunity (GO:0002714)2.80411942
96positive regulation of immunoglobulin mediated immune response (GO:0002891)2.80411942
97DNA replication checkpoint (GO:0000076)2.79983965
98transcription initiation from RNA polymerase I promoter (GO:0006361)2.79354040
99positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.78584258
100protein neddylation (GO:0045116)2.78511363

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.86511894
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.54360328
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.30284257
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.79135524
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.69571000
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.06733665
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.94778118
8RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.73846665
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.69494827
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.68287160
11E2F7_22180533_ChIP-Seq_HELA_Human2.67057671
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.63340625
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.62371134
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.55664213
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.50261130
16VDR_23849224_ChIP-Seq_CD4+_Human2.44262136
17FOXP3_21729870_ChIP-Seq_TREG_Human2.42202736
18ELK1_19687146_ChIP-ChIP_HELA_Human2.42006877
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.30757844
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.23062287
21EWS_26573619_Chip-Seq_HEK293_Human2.22062962
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.16977452
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.15839047
24FLI1_27457419_Chip-Seq_LIVER_Mouse2.14975137
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.09342422
26ZNF274_21170338_ChIP-Seq_K562_Hela1.92790083
27TAF15_26573619_Chip-Seq_HEK293_Human1.92227303
28MYC_19030024_ChIP-ChIP_MESCs_Mouse1.86422123
29RBPJ_22232070_ChIP-Seq_NCS_Mouse1.85534946
30TTF2_22483619_ChIP-Seq_HELA_Human1.81104579
31DCP1A_22483619_ChIP-Seq_HELA_Human1.79099128
32IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.76317378
33NOTCH1_21737748_ChIP-Seq_TLL_Human1.73062022
34VDR_22108803_ChIP-Seq_LS180_Human1.72723955
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71271024
36MYC_18940864_ChIP-ChIP_HL60_Human1.66074913
37SRF_21415370_ChIP-Seq_HL-1_Mouse1.65993827
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.63883647
39MYC_18358816_ChIP-ChIP_MESCs_Mouse1.63080879
40PADI4_21655091_ChIP-ChIP_MCF-7_Human1.57872115
41EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.53795316
42CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.52123719
43MYC_19079543_ChIP-ChIP_MESCs_Mouse1.51708304
44FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.50187651
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.45433328
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41850370
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.37047130
48XRN2_22483619_ChIP-Seq_HELA_Human1.36316764
49FUS_26573619_Chip-Seq_HEK293_Human1.35955809
50TP53_22573176_ChIP-Seq_HFKS_Human1.35870494
51POU5F1_16153702_ChIP-ChIP_HESCs_Human1.33625351
52LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33503800
53POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30145045
54MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28279536
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.27745265
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26582959
57GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24270559
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.22305791
59PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.20414725
60NELFA_20434984_ChIP-Seq_ESCs_Mouse1.19703803
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19643901
62IRF8_21731497_ChIP-ChIP_J774_Mouse1.19610397
63CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16611047
64CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.16208773
65ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15885879
66PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.11825980
67GABP_19822575_ChIP-Seq_HepG2_Human1.10450375
68IGF1R_20145208_ChIP-Seq_DFB_Human1.08958531
69GATA1_26923725_Chip-Seq_HPCs_Mouse1.08779432
70SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.08464294
71MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.08004398
72P300_19829295_ChIP-Seq_ESCs_Human1.06992873
73E2F1_18555785_ChIP-Seq_MESCs_Mouse1.06556755
74EGR1_23403033_ChIP-Seq_LIVER_Mouse1.06307133
75ERG_20517297_ChIP-Seq_VCAP_Human1.03536051
76ER_23166858_ChIP-Seq_MCF-7_Human1.03426227
77ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01459687
78ELK1_22589737_ChIP-Seq_MCF10A_Human1.00599477
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98340470
80CBP_20019798_ChIP-Seq_JUKART_Human0.98340470
81FOXA1_25329375_ChIP-Seq_VCAP_Human0.98034259
82FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98034259
83SOX2_18555785_ChIP-Seq_MESCs_Mouse0.97807692
84NANOG_16153702_ChIP-ChIP_HESCs_Human0.95433061
85NANOG_19829295_ChIP-Seq_ESCs_Human0.94391648
86SOX2_19829295_ChIP-Seq_ESCs_Human0.94391648
87KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.93942210
88TCF4_22108803_ChIP-Seq_LS180_Human0.93862217
89PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.92409116
90HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.90829649
91TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.89306239
92IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.88530110
93KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.88107185
94KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.88107185
95KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.88107185
96SOX2_16153702_ChIP-ChIP_HESCs_Human0.85565265
97POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.85338223
98CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.84609666
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.82659931
100TDRD3_21172665_ChIP-Seq_MCF-7_Human0.82587581

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001873_stomach_inflammation6.56028300
2MP0001348_abnormal_lacrimal_gland4.39511714
3MP0001835_abnormal_antigen_presentation4.00853742
4MP0006292_abnormal_olfactory_placode3.43433113
5MP0005671_abnormal_response_to3.29019386
6MP0008875_abnormal_xenobiotic_pharmacok3.18867137
7MP0008058_abnormal_DNA_repair2.93501203
8MP0002102_abnormal_ear_morphology2.91942366
9MP0002234_abnormal_pharynx_morphology2.64825966
10MP0008872_abnormal_physiological_respon2.30452058
11MP0003693_abnormal_embryo_hatching2.07928147
12MP0006082_CNS_inflammation2.07700419
13MP0005646_abnormal_pituitary_gland2.04440211
14MP0003283_abnormal_digestive_organ2.02564321
15MP0003136_yellow_coat_color2.01163004
16MP0010094_abnormal_chromosome_stability1.90441335
17MP0003786_premature_aging1.88026069
18MP0003938_abnormal_ear_development1.76546092
19MP0005084_abnormal_gallbladder_morpholo1.74830630
20MP0003806_abnormal_nucleotide_metabolis1.69824845
21MP0002736_abnormal_nociception_after1.63983674
22MP0008877_abnormal_DNA_methylation1.62316248
23MP0003567_abnormal_fetal_cardiomyocyte1.61173352
24MP0004142_abnormal_muscle_tone1.57470181
25MP0002277_abnormal_respiratory_mucosa1.57228504
26MP0000383_abnormal_hair_follicle1.55151647
27MP0003950_abnormal_plasma_membrane1.53865329
28MP0000049_abnormal_middle_ear1.51270890
29MP0002254_reproductive_system_inflammat1.50660228
30MP0005310_abnormal_salivary_gland1.48154731
31MP0009333_abnormal_splenocyte_physiolog1.46931186
32MP0002282_abnormal_trachea_morphology1.46100216
33MP0001663_abnormal_digestive_system1.43446158
34MP0004742_abnormal_vestibular_system1.39020240
35MP0005387_immune_system_phenotype1.36352116
36MP0001790_abnormal_immune_system1.36352116
37MP0003195_calcinosis1.36127591
38MP0004957_abnormal_blastocyst_morpholog1.31489664
39MP0003890_abnormal_embryonic-extraembry1.30977187
40MP0005645_abnormal_hypothalamus_physiol1.28934542
41MP0002638_abnormal_pupillary_reflex1.28227080
42MP0008789_abnormal_olfactory_epithelium1.24390505
43MP0002938_white_spotting1.24249580
44MP0006072_abnormal_retinal_apoptosis1.23595569
45MP0003718_maternal_effect1.23083976
46MP0003763_abnormal_thymus_physiology1.22410831
47MP0005551_abnormal_eye_electrophysiolog1.21210736
48MP0003077_abnormal_cell_cycle1.20934325
49MP0002160_abnormal_reproductive_system1.19401312
50MP0003111_abnormal_nucleus_morphology1.16840314
51MP0001485_abnormal_pinna_reflex1.16065793
52MP0000372_irregular_coat_pigmentation1.12374278
53MP0002148_abnormal_hypersensitivity_rea1.07241769
54MP0001800_abnormal_humoral_immune1.05541159
55MP0002751_abnormal_autonomic_nervous1.02402418
56MP0008995_early_reproductive_senescence0.99669248
57MP0005381_digestive/alimentary_phenotyp0.99230730
58MP0001346_abnormal_lacrimal_gland0.99100177
59MP0001293_anophthalmia0.98354408
60MP0005000_abnormal_immune_tolerance0.96833250
61MP0009785_altered_susceptibility_to0.96228458
62MP0000631_abnormal_neuroendocrine_gland0.96024088
63MP0002006_tumorigenesis0.95255847
64MP0003186_abnormal_redox_activity0.92667366
65MP0005253_abnormal_eye_physiology0.91641258
66MP0001502_abnormal_circadian_rhythm0.88657650
67MP0005083_abnormal_biliary_tract0.84638898
68MP0001968_abnormal_touch/_nociception0.84076403
69MP0002138_abnormal_hepatobiliary_system0.82496588
70MP0010678_abnormal_skin_adnexa0.80510323
71MP0004147_increased_porphyrin_level0.80435027
72MP0003119_abnormal_digestive_system0.79936685
73MP0009053_abnormal_anal_canal0.78492338
74MP0004782_abnormal_surfactant_physiolog0.76486173
75MP0003011_delayed_dark_adaptation0.75502155
76MP0003937_abnormal_limbs/digits/tail_de0.74117646
77MP0002166_altered_tumor_susceptibility0.73625578
78MP0003866_abnormal_defecation0.73458683
79MP0005389_reproductive_system_phenotype0.72998351
80MP0002405_respiratory_system_inflammati0.71980931
81MP0001188_hyperpigmentation0.71606493
82MP0002249_abnormal_larynx_morphology0.71353306
83MP0002210_abnormal_sex_determination0.70498863
84MP0002090_abnormal_vision0.69654023
85MP0010155_abnormal_intestine_physiology0.69560941
86MP0000685_abnormal_immune_system0.65833671
87MP0000613_abnormal_salivary_gland0.64866272
88MP0005499_abnormal_olfactory_system0.63245472
89MP0005394_taste/olfaction_phenotype0.63245472
90MP0008057_abnormal_DNA_replication0.62935749
91MP0004145_abnormal_muscle_electrophysio0.60789246
92MP0000470_abnormal_stomach_morphology0.60304656
93MP0003880_abnormal_central_pattern0.59403682
94MP0005167_abnormal_blood-brain_barrier0.59112350
95MP0002693_abnormal_pancreas_physiology0.58848588
96MP0006035_abnormal_mitochondrial_morpho0.58564623
97MP0001666_abnormal_nutrient_absorption0.58279970
98MP0004885_abnormal_endolymph0.57655609
99MP0005085_abnormal_gallbladder_physiolo0.57606629
100MP0002876_abnormal_thyroid_physiology0.57467374

Predicted human phenotypes

RankGene SetZ-score
1Reduced antithrombin III activity (HP:0001976)3.91736041
2Abnormality of the pons (HP:0007361)3.80192131
3Acute necrotizing encephalopathy (HP:0006965)3.66790703
4Hypoplasia of the pons (HP:0012110)3.52856753
5Stomatitis (HP:0010280)3.47151348
6Increased hepatocellular lipid droplets (HP:0006565)3.45858242
7Methylmalonic acidemia (HP:0002912)3.38035625
8Hypoproteinemia (HP:0003075)3.19685483
9Mitochondrial inheritance (HP:0001427)3.19519375
10Abnormal mitochondria in muscle tissue (HP:0008316)3.18083825
11Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.17125923
12Abnormality of alanine metabolism (HP:0010916)3.17125923
13Hyperalaninemia (HP:0003348)3.17125923
14Acute encephalopathy (HP:0006846)3.10746783
15Type I transferrin isoform profile (HP:0003642)3.05504260
16Increased CSF lactate (HP:0002490)3.03389070
17Lipid accumulation in hepatocytes (HP:0006561)2.99580310
18Progressive macrocephaly (HP:0004481)2.96976309
193-Methylglutaconic aciduria (HP:0003535)2.87131783
20Visual hallucinations (HP:0002367)2.77334429
21Congenital, generalized hypertrichosis (HP:0004540)2.76573405
22B lymphocytopenia (HP:0010976)2.73581928
23Colon cancer (HP:0003003)2.72844103
24Pendular nystagmus (HP:0012043)2.62382521
25Exertional dyspnea (HP:0002875)2.61887201
26Methylmalonic aciduria (HP:0012120)2.61453826
27Ependymoma (HP:0002888)2.59329589
28Autoimmune thrombocytopenia (HP:0001973)2.55354082
29Absent rod-and cone-mediated responses on ERG (HP:0007688)2.50573230
30Dyschromatopsia (HP:0007641)2.47749842
31Increased serum lactate (HP:0002151)2.47398083
32Testicular atrophy (HP:0000029)2.46971312
33Renal Fanconi syndrome (HP:0001994)2.45112010
34Increased neuronal autofluorescent lipopigment (HP:0002074)2.45065123
35Aplastic anemia (HP:0001915)2.44083315
36Hypochromic microcytic anemia (HP:0004840)2.41657772
37Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.40680811
38Abnormal protein N-linked glycosylation (HP:0012347)2.40680811
39Abnormal protein glycosylation (HP:0012346)2.40680811
40Abnormal glycosylation (HP:0012345)2.40680811
41Decreased central vision (HP:0007663)2.39366226
42Nephronophthisis (HP:0000090)2.38345977
43Abnormality of B cell number (HP:0010975)2.38087789
44Spastic diplegia (HP:0001264)2.35165683
45Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.31506573
46Large for gestational age (HP:0001520)2.31309318
47Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.28132544
48Confusion (HP:0001289)2.27255470
49Renal cortical cysts (HP:0000803)2.26402653
50Megaloblastic anemia (HP:0001889)2.25975639
51Agitation (HP:0000713)2.24175520
52Abnormality of the vitamin B12 metabolism (HP:0004341)2.24124931
53Septo-optic dysplasia (HP:0100842)2.23083455
54Pancreatic cysts (HP:0001737)2.22450969
55Cerebral edema (HP:0002181)2.20393266
56Hepatocellular necrosis (HP:0001404)2.18341957
57Optic disc pallor (HP:0000543)2.18283499
58Exercise intolerance (HP:0003546)2.18243339
59IgG deficiency (HP:0004315)2.17501564
60Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.17347895
61Decreased activity of mitochondrial respiratory chain (HP:0008972)2.17347895
62Autoimmune hemolytic anemia (HP:0001890)2.16800326
63True hermaphroditism (HP:0010459)2.15538147
64Hypoplasia of the ulna (HP:0003022)2.14744752
65Aplasia/Hypoplasia of the ulna (HP:0006495)2.13411260
66Abnormal number of incisors (HP:0011064)2.12010321
67Central scotoma (HP:0000603)2.11997473
68Intestinal atresia (HP:0011100)2.11933054
69Lethargy (HP:0001254)2.10911203
70Abnormality of vitamin B metabolism (HP:0004340)2.10884111
71Thyroid-stimulating hormone excess (HP:0002925)2.09964296
72Macrocytic anemia (HP:0001972)2.09568948
73Increased intramyocellular lipid droplets (HP:0012240)2.09478136
74Cleft eyelid (HP:0000625)2.08875408
75Bilateral microphthalmos (HP:0007633)2.05383124
76Aplasia/hypoplasia of the uterus (HP:0008684)2.05115214
77Pancytopenia (HP:0001876)2.03057356
78Abnormality of the renal cortex (HP:0011035)2.01641976
79Lactic acidosis (HP:0003128)2.01295296
80Abnormality of serum amino acid levels (HP:0003112)2.01289490
81Pancreatic fibrosis (HP:0100732)1.99429422
82Abnormality of the labia minora (HP:0012880)1.99076527
83Abnormal pupillary function (HP:0007686)1.98072853
84Abnormality of the renal medulla (HP:0100957)1.97111867
85Agnosia (HP:0010524)1.92581652
86Respiratory failure (HP:0002878)1.92193435
87Asplenia (HP:0001746)1.91893641
88Abnormal rod and cone electroretinograms (HP:0008323)1.90523004
89Severe combined immunodeficiency (HP:0004430)1.90202345
90Abnormality of the prostate (HP:0008775)1.90165446
91Congenital stationary night blindness (HP:0007642)1.90092047
92Aplasia/Hypoplasia of the spleen (HP:0010451)1.90084624
93Multiple enchondromatosis (HP:0005701)1.89748244
94Attenuation of retinal blood vessels (HP:0007843)1.88682547
95Abnormality of the ileum (HP:0001549)1.87636229
96Esophageal atresia (HP:0002032)1.86305011
97Leukodystrophy (HP:0002415)1.86030425
98Hepatic necrosis (HP:0002605)1.85864009
99Gastrointestinal atresia (HP:0002589)1.85264677
100Abnormality of the phalanges of the 2nd finger (HP:0009541)1.84341637

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK6.80187031
2TXK3.11536614
3VRK23.05704504
4TSSK62.89142166
5CDK192.79471234
6BUB12.74555233
7NME12.41745268
8MKNK12.38612761
9TRIM282.29021743
10ZAK2.28399826
11MAP4K12.26338114
12TLK12.21287722
13EIF2AK12.15937111
14EIF2AK32.03121596
15PNCK1.96277079
16NEK11.92152073
17MST41.86766490
18WEE11.82291140
19TAF11.69086645
20VRK11.65280681
21TAOK31.62757999
22TNIK1.60509011
23SCYL21.47327352
24ADRBK21.46257840
25PLK41.41985358
26STK41.35140432
27MAP4K21.34652288
28GRK11.32147961
29PLK31.30637213
30BCKDK1.30203775
31SRPK11.28410280
32MKNK21.25782136
33NUAK11.25255895
34CDC71.22720402
35MAP3K121.21272892
36BMPR21.16331543
37INSRR1.13021044
38NME21.10093411
39FRK1.07732319
40OXSR11.01710075
41WNK30.98160358
42WNK40.96850468
43BRSK20.89451527
44STK390.85071624
45BRD40.82954243
46TEC0.78333960
47EPHA40.74209051
48PASK0.71885442
49MAP2K60.70856974
50PLK10.69588153
51IKBKB0.69321358
52NEK90.67452326
53BMPR1B0.60416892
54MYLK0.59258517
55PAK40.59140302
56KIT0.58038768
57DYRK30.57704355
58CDK80.57432647
59CHEK20.51276127
60PIK3CG0.50989436
61ATR0.50239069
62ITK0.48001868
63BCR0.47844663
64PLK20.45611828
65AURKB0.45286863
66CCNB10.44614848
67BRSK10.44360129
68TIE10.44180137
69DYRK20.43906854
70MAP3K40.43226854
71MAP2K40.40045665
72TTK0.39452640
73ALK0.39245058
74ADRBK10.39149207
75RPS6KA50.38733187
76RPS6KB10.38406019
77CSNK1A10.37018981
78CSNK2A20.36201454
79CSNK2A10.36111614
80FGFR10.35751475
81ZAP700.35126245
82AKT30.34621112
83TNK20.34502627
84EIF2AK20.32666148
85CAMK2D0.32642428
86MUSK0.32503186
87MAP2K30.32247150
88IRAK10.31984507
89IKBKE0.29521814
90MAP3K50.28971168
91TGFBR10.27802940
92STK160.25841323
93BTK0.25340641
94GSK3A0.24897125
95MAP2K70.24846189
96CAMKK20.23726565
97SYK0.23398298
98ATM0.23283410
99CSNK1E0.22720598
100AURKA0.22619420

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.93041880
2Ribosome_Homo sapiens_hsa030103.21089984
3Asthma_Homo sapiens_hsa053103.12395037
4Allograft rejection_Homo sapiens_hsa053303.04365087
5RNA polymerase_Homo sapiens_hsa030202.99328314
6Protein export_Homo sapiens_hsa030602.85595617
7Oxidative phosphorylation_Homo sapiens_hsa001902.67199900
8Autoimmune thyroid disease_Homo sapiens_hsa053202.60683807
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.51019268
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.37576100
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.31656547
12Mismatch repair_Homo sapiens_hsa034302.19279480
13Parkinsons disease_Homo sapiens_hsa050122.11687277
14DNA replication_Homo sapiens_hsa030302.07805850
15Spliceosome_Homo sapiens_hsa030402.05055881
16Homologous recombination_Homo sapiens_hsa034402.02885938
17RNA degradation_Homo sapiens_hsa030182.01272823
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.87267494
19Fanconi anemia pathway_Homo sapiens_hsa034601.85043698
20RNA transport_Homo sapiens_hsa030131.84540925
21Pyrimidine metabolism_Homo sapiens_hsa002401.62794718
22Basal transcription factors_Homo sapiens_hsa030221.59772527
23Huntingtons disease_Homo sapiens_hsa050161.44340061
24Systemic lupus erythematosus_Homo sapiens_hsa053221.38659319
25Nucleotide excision repair_Homo sapiens_hsa034201.28183472
26Purine metabolism_Homo sapiens_hsa002301.27829211
27Non-homologous end-joining_Homo sapiens_hsa034501.27202090
28Propanoate metabolism_Homo sapiens_hsa006401.20184155
29One carbon pool by folate_Homo sapiens_hsa006701.18371193
30Graft-versus-host disease_Homo sapiens_hsa053321.17621193
31Alzheimers disease_Homo sapiens_hsa050101.14799549
32Type I diabetes mellitus_Homo sapiens_hsa049401.13705326
33Hematopoietic cell lineage_Homo sapiens_hsa046401.12197799
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.11830076
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.06594744
36Primary immunodeficiency_Homo sapiens_hsa053401.04988228
37T cell receptor signaling pathway_Homo sapiens_hsa046601.03574969
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.00790492
39Linoleic acid metabolism_Homo sapiens_hsa005910.99627539
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.96083961
41Peroxisome_Homo sapiens_hsa041460.93996013
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93454244
43Phototransduction_Homo sapiens_hsa047440.92465370
44Nitrogen metabolism_Homo sapiens_hsa009100.90392785
45Cyanoamino acid metabolism_Homo sapiens_hsa004600.87967637
46Rheumatoid arthritis_Homo sapiens_hsa053230.86792715
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83468750
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83395290
49Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.83383090
50Steroid biosynthesis_Homo sapiens_hsa001000.82864521
51alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.81835131
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81541150
53Vitamin digestion and absorption_Homo sapiens_hsa049770.81156777
54Ether lipid metabolism_Homo sapiens_hsa005650.79304886
55mRNA surveillance pathway_Homo sapiens_hsa030150.78753496
56Glutathione metabolism_Homo sapiens_hsa004800.74974155
57Cysteine and methionine metabolism_Homo sapiens_hsa002700.74706697
58Antigen processing and presentation_Homo sapiens_hsa046120.72224962
59Butanoate metabolism_Homo sapiens_hsa006500.71231819
60Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.69424936
61Base excision repair_Homo sapiens_hsa034100.67714945
62Collecting duct acid secretion_Homo sapiens_hsa049660.67414935
63N-Glycan biosynthesis_Homo sapiens_hsa005100.64917554
64Tryptophan metabolism_Homo sapiens_hsa003800.62279778
65Cardiac muscle contraction_Homo sapiens_hsa042600.62052405
66Regulation of autophagy_Homo sapiens_hsa041400.60389664
67Caffeine metabolism_Homo sapiens_hsa002320.57851164
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.57848704
69Retinol metabolism_Homo sapiens_hsa008300.56562227
70Metabolic pathways_Homo sapiens_hsa011000.55542779
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52685648
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51409037
73Olfactory transduction_Homo sapiens_hsa047400.50479041
74Cell cycle_Homo sapiens_hsa041100.49561785
75Jak-STAT signaling pathway_Homo sapiens_hsa046300.47109034
76Measles_Homo sapiens_hsa051620.46599737
77Pyruvate metabolism_Homo sapiens_hsa006200.46128753
78Fat digestion and absorption_Homo sapiens_hsa049750.41357163
79Arginine and proline metabolism_Homo sapiens_hsa003300.41245707
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40572612
81Arachidonic acid metabolism_Homo sapiens_hsa005900.40236501
82NOD-like receptor signaling pathway_Homo sapiens_hsa046210.38171624
83Hedgehog signaling pathway_Homo sapiens_hsa043400.37737920
84Alcoholism_Homo sapiens_hsa050340.37548375
85Epstein-Barr virus infection_Homo sapiens_hsa051690.36090710
86Fatty acid degradation_Homo sapiens_hsa000710.35779332
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35163522
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.34433950
89Selenocompound metabolism_Homo sapiens_hsa004500.33247392
90Chemical carcinogenesis_Homo sapiens_hsa052040.32210285
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.30813609
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.29909488
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29574503
94Basal cell carcinoma_Homo sapiens_hsa052170.28475744
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.25684504
96Histidine metabolism_Homo sapiens_hsa003400.24149104
97Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.23335370
98Glycerolipid metabolism_Homo sapiens_hsa005610.22129591
99beta-Alanine metabolism_Homo sapiens_hsa004100.21989432
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.21910596

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