HNRNPA1P21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to interleukin-15 (GO:0071350)5.25247994
2DNA deamination (GO:0045006)5.24763889
3regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.97288880
4cytidine metabolic process (GO:0046087)4.83542257
5cytidine catabolic process (GO:0006216)4.83542257
6cytidine deamination (GO:0009972)4.83542257
7tolerance induction (GO:0002507)4.51001978
8response to interleukin-15 (GO:0070672)4.46722915
9mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.40073577
10regulation of chronic inflammatory response (GO:0002676)4.38788969
11ribosomal small subunit assembly (GO:0000028)4.33237112
12pyrimidine ribonucleoside catabolic process (GO:0046133)4.32925981
13negative T cell selection (GO:0043383)4.21020507
14ATP synthesis coupled proton transport (GO:0015986)4.19274987
15energy coupled proton transport, down electrochemical gradient (GO:0015985)4.19274987
16regulation of isotype switching to IgG isotypes (GO:0048302)4.08905351
17regulation of regulatory T cell differentiation (GO:0045589)4.00670181
18negative thymic T cell selection (GO:0045060)3.93445391
19T cell migration (GO:0072678)3.67406647
20positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.59947310
21positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.56837090
22positive regulation of granulocyte differentiation (GO:0030854)3.53851219
23regulation of T cell receptor signaling pathway (GO:0050856)3.47107968
24sequestering of actin monomers (GO:0042989)3.46171968
25establishment of protein localization to mitochondrial membrane (GO:0090151)3.38224871
26positive regulation of alpha-beta T cell proliferation (GO:0046641)3.37039156
27positive regulation of natural killer cell mediated immunity (GO:0002717)3.29336057
28positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.28655561
29mast cell activation (GO:0045576)3.26803216
30viral transcription (GO:0019083)3.22958666
31regulation of T cell tolerance induction (GO:0002664)3.20252344
32regulation of B cell receptor signaling pathway (GO:0050855)3.18364247
33positive regulation of gamma-delta T cell activation (GO:0046645)3.18272482
34interferon-gamma production (GO:0032609)3.18112359
35regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.17961648
36translational termination (GO:0006415)3.16782246
37regulation of alpha-beta T cell proliferation (GO:0046640)3.16609550
38positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.10435170
39maturation of SSU-rRNA (GO:0030490)3.09930680
40thymic T cell selection (GO:0045061)3.07272567
41SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.06552120
42proteasome assembly (GO:0043248)3.06147823
43rRNA modification (GO:0000154)3.05343441
44negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.04691389
45rRNA catabolic process (GO:0016075)3.03907814
46cotranslational protein targeting to membrane (GO:0006613)3.03709386
47negative regulation of B cell activation (GO:0050869)3.02131401
48T cell receptor signaling pathway (GO:0050852)3.01742090
49positive regulation of tolerance induction (GO:0002645)3.01738514
50protein targeting to ER (GO:0045047)2.99117515
51activated T cell proliferation (GO:0050798)2.98963446
52positive thymic T cell selection (GO:0045059)2.98309538
53positive regulation of B cell differentiation (GO:0045579)2.96440719
54regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.95661786
55regulation of natural killer cell mediated immunity (GO:0002715)2.95661786
56chaperone-mediated protein transport (GO:0072321)2.94681077
57alpha-beta T cell differentiation (GO:0046632)2.94181463
58positive T cell selection (GO:0043368)2.93900063
59DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.90838699
60positive regulation of cell killing (GO:0031343)2.90727504
61antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.89968723
62translational elongation (GO:0006414)2.88457772
63mast cell activation involved in immune response (GO:0002279)2.87863067
64mast cell degranulation (GO:0043303)2.87863067
65signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.85522475
66signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.85522475
67signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.85522475
68inner mitochondrial membrane organization (GO:0007007)2.84712038
69establishment of protein localization to endoplasmic reticulum (GO:0072599)2.82614526
70intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.81515604
71signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.81515604
72antigen receptor-mediated signaling pathway (GO:0050851)2.81082425
73regulation of B cell differentiation (GO:0045577)2.79150174
74protein localization to endoplasmic reticulum (GO:0070972)2.79106911
75CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.78946688
76T-helper cell differentiation (GO:0042093)2.78946688
77regulation of leukocyte mediated cytotoxicity (GO:0001910)2.78245412
78negative regulation of B cell proliferation (GO:0030889)2.77797424
79negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.75424703
80lymphocyte costimulation (GO:0031294)2.74482415
81regulation of interleukin-2 biosynthetic process (GO:0045076)2.74231131
82alpha-beta T cell activation (GO:0046631)2.72173271
83negative regulation of cell killing (GO:0031342)2.72066989
84negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.72066989
85negative regulation of ligase activity (GO:0051352)2.70874951
86negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.70874951
87signal transduction involved in DNA integrity checkpoint (GO:0072401)2.70708712
88signal transduction involved in DNA damage checkpoint (GO:0072422)2.70708712
89alpha-beta T cell differentiation involved in immune response (GO:0002293)2.70142088
90alpha-beta T cell activation involved in immune response (GO:0002287)2.70142088
91T cell differentiation involved in immune response (GO:0002292)2.70142088
92regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.69319569
93positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.68937054
94CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.68330281
95rRNA methylation (GO:0031167)2.67181409
96signal transduction involved in cell cycle checkpoint (GO:0072395)2.66950302
97exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.65248287
98regulation of gamma-delta T cell differentiation (GO:0045586)2.65022648
99T cell costimulation (GO:0031295)2.64163552
100respiratory chain complex IV assembly (GO:0008535)2.63842318

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.37580345
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.15492945
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.78917240
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.75605658
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.61679208
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.23179036
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.19473790
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.10536196
9NOTCH1_21737748_ChIP-Seq_TLL_Human3.06436729
10VDR_23849224_ChIP-Seq_CD4+_Human2.85146654
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.84850481
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.80639617
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.71971240
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.62110070
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.59307097
16FOXP3_21729870_ChIP-Seq_TREG_Human2.55280106
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.51120087
18VDR_22108803_ChIP-Seq_LS180_Human2.50325892
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.48265372
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.46445488
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.45285309
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.40216506
23ELK1_19687146_ChIP-ChIP_HELA_Human2.36647183
24MYB_26560356_Chip-Seq_TH2_Human2.31208145
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.25060369
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.20331821
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.03492537
28FLI1_27457419_Chip-Seq_LIVER_Mouse2.01944323
29E2F7_22180533_ChIP-Seq_HELA_Human1.94860073
30ZNF274_21170338_ChIP-Seq_K562_Hela1.91790741
31MYC_18555785_ChIP-Seq_MESCs_Mouse1.90759527
32GATA3_26560356_Chip-Seq_TH2_Human1.83109342
33HOXB4_20404135_ChIP-ChIP_EML_Mouse1.81538402
34IRF8_21731497_ChIP-ChIP_J774_Mouse1.75393088
35RUNX_20019798_ChIP-Seq_JUKART_Human1.67246901
36STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.64249300
37STAT4_19710469_ChIP-ChIP_TH1__Mouse1.59250799
38SRF_21415370_ChIP-Seq_HL-1_Mouse1.58328829
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.57740057
40FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.57016231
41PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.56137827
42FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.52565307
43HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.49333454
44DCP1A_22483619_ChIP-Seq_HELA_Human1.48216225
45IRF1_19129219_ChIP-ChIP_H3396_Human1.48112835
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47284909
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.47277940
48MYC_18940864_ChIP-ChIP_HL60_Human1.45057438
49GATA3_27048872_Chip-Seq_THYMUS_Human1.43649057
50TTF2_22483619_ChIP-Seq_HELA_Human1.41122957
51CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.40784195
52MYC_18358816_ChIP-ChIP_MESCs_Mouse1.40643687
53PADI4_21655091_ChIP-ChIP_MCF-7_Human1.38846958
54CIITA_25753668_ChIP-Seq_RAJI_Human1.36789345
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.35644567
56BP1_19119308_ChIP-ChIP_Hs578T_Human1.34934953
57MYC_19030024_ChIP-ChIP_MESCs_Mouse1.31061827
58PCGF2_27294783_Chip-Seq_NPCs_Mouse1.29573885
59MYB_26560356_Chip-Seq_TH1_Human1.26180996
60MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.23058193
61XRN2_22483619_ChIP-Seq_HELA_Human1.19697768
62ELK1_22589737_ChIP-Seq_MCF10A_Human1.18222275
63EWS_26573619_Chip-Seq_HEK293_Human1.17528076
64MYC_19079543_ChIP-ChIP_MESCs_Mouse1.16951895
65SPI1_23547873_ChIP-Seq_NB4_Human1.14615849
66RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.13753860
67PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11242771
68GABP_19822575_ChIP-Seq_HepG2_Human1.10472226
69FOXM1_23109430_ChIP-Seq_U2OS_Human1.08012797
70POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.05063218
71FUS_26573619_Chip-Seq_HEK293_Human1.04173019
72TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.03552815
73FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.03445919
74FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01325519
75CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.99994705
76SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98704367
77PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.98562225
78NFE2_27457419_Chip-Seq_LIVER_Mouse0.97884343
79EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.97879304
80TP53_22573176_ChIP-Seq_HFKS_Human0.96827679
81IGF1R_20145208_ChIP-Seq_DFB_Human0.95917757
82EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95639501
83TAF15_26573619_Chip-Seq_HEK293_Human0.94898817
84EZH2_27294783_Chip-Seq_NPCs_Mouse0.94685339
85GATA3_26560356_Chip-Seq_TH1_Human0.93917126
86FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.92795287
87ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.92727854
88THAP11_20581084_ChIP-Seq_MESCs_Mouse0.92605624
89E2F1_18555785_ChIP-Seq_MESCs_Mouse0.91520928
90NELFA_20434984_ChIP-Seq_ESCs_Mouse0.90390277
91POU5F1_16153702_ChIP-ChIP_HESCs_Human0.89460295
92CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.88645020
93BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87977894
94CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86325692
95KDM5A_27292631_Chip-Seq_BREAST_Human0.85707071
96AR_20517297_ChIP-Seq_VCAP_Human0.84462781
97FOXA1_27270436_Chip-Seq_PROSTATE_Human0.83735712
98FOXA1_25329375_ChIP-Seq_VCAP_Human0.83735712
99GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.83600345
100MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.82413845

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.89019531
2MP0003763_abnormal_thymus_physiology3.15422484
3MP0000372_irregular_coat_pigmentation2.97951521
4MP0001873_stomach_inflammation2.92353245
5MP0001835_abnormal_antigen_presentation2.85741793
6MP0001800_abnormal_humoral_immune2.84575817
7MP0005000_abnormal_immune_tolerance2.72550220
8MP0000685_abnormal_immune_system2.60724751
9MP0009333_abnormal_splenocyte_physiolog2.52472605
10MP0009785_altered_susceptibility_to2.45242245
11MP0002277_abnormal_respiratory_mucosa2.44477145
12MP0001790_abnormal_immune_system2.34978124
13MP0005387_immune_system_phenotype2.34978124
14MP0002723_abnormal_immune_serum2.26970199
15MP0002148_abnormal_hypersensitivity_rea2.25453724
16MP0002420_abnormal_adaptive_immunity2.14404092
17MP0001819_abnormal_immune_cell2.12810172
18MP0002163_abnormal_gland_morphology2.08102648
19MP0008877_abnormal_DNA_methylation2.02984329
20MP0002452_abnormal_antigen_presenting2.01678114
21MP0002166_altered_tumor_susceptibility1.98181273
22MP0008058_abnormal_DNA_repair1.97588481
23MP0003866_abnormal_defecation1.95661311
24MP0002398_abnormal_bone_marrow1.94378205
25MP0004381_abnormal_hair_follicle1.93359725
26MP0002006_tumorigenesis1.90771787
27MP0005025_abnormal_response_to1.88857088
28MP0000703_abnormal_thymus_morphology1.84147222
29MP0005075_abnormal_melanosome_morpholog1.78353137
30MP0003693_abnormal_embryo_hatching1.77747212
31MP0000716_abnormal_immune_system1.76753666
32MP0002405_respiratory_system_inflammati1.70129413
33MP0000689_abnormal_spleen_morphology1.69478083
34MP0009379_abnormal_foot_pigmentation1.66205150
35MP0004145_abnormal_muscle_electrophysio1.65248091
36MP0010155_abnormal_intestine_physiology1.63914667
37MP0002102_abnormal_ear_morphology1.60351111
38MP0003436_decreased_susceptibility_to1.60155330
39MP0010094_abnormal_chromosome_stability1.57652360
40MP0006082_CNS_inflammation1.56867001
41MP0008872_abnormal_physiological_respon1.56549210
42MP0002722_abnormal_immune_system1.51787912
43MP0006072_abnormal_retinal_apoptosis1.50553345
44MP0003724_increased_susceptibility_to1.47559666
45MP0002638_abnormal_pupillary_reflex1.46229275
46MP0002429_abnormal_blood_cell1.40129290
47MP0004957_abnormal_blastocyst_morpholog1.34833166
48MP0001845_abnormal_inflammatory_respons1.34568937
49MP0005379_endocrine/exocrine_gland_phen1.34212960
50MP0002396_abnormal_hematopoietic_system1.23455354
51MP0005310_abnormal_salivary_gland1.21575419
52MP0006036_abnormal_mitochondrial_physio1.19891288
53MP0003786_premature_aging1.17787909
54MP0002419_abnormal_innate_immunity1.16575183
55MP0001853_heart_inflammation1.16525584
56MP0008875_abnormal_xenobiotic_pharmacok1.16257205
57MP0003045_fibrosis1.16043278
58MP0001986_abnormal_taste_sensitivity1.15085756
59MP0002019_abnormal_tumor_incidence1.13465600
60MP0005645_abnormal_hypothalamus_physiol1.09950870
61MP0005084_abnormal_gallbladder_morpholo1.01009505
62MP0000490_abnormal_crypts_of0.99748174
63MP0001348_abnormal_lacrimal_gland0.98901472
64MP0001905_abnormal_dopamine_level0.98834482
65MP0003077_abnormal_cell_cycle0.94061083
66MP0001919_abnormal_reproductive_system0.93941237
67MP0008469_abnormal_protein_level0.92657062
68MP0002933_joint_inflammation0.91991138
69MP0003567_abnormal_fetal_cardiomyocyte0.90647460
70MP0006276_abnormal_autonomic_nervous0.90243039
71MP0009764_decreased_sensitivity_to0.89960858
72MP0009765_abnormal_xenobiotic_induced0.88289412
73MP0005389_reproductive_system_phenotype0.87813189
74MP0006035_abnormal_mitochondrial_morpho0.86343303
75MP0003111_abnormal_nucleus_morphology0.86319713
76MP0003806_abnormal_nucleotide_metabolis0.84052159
77MP0004147_increased_porphyrin_level0.83198784
78MP0002693_abnormal_pancreas_physiology0.80914387
79MP0002095_abnormal_skin_pigmentation0.79860237
80MP0008007_abnormal_cellular_replicative0.79767653
81MP0003880_abnormal_central_pattern0.78765657
82MP0009763_increased_sensitivity_to0.77951593
83MP0001119_abnormal_female_reproductive0.76964291
84MP0000465_gastrointestinal_hemorrhage0.74107408
85MP0002876_abnormal_thyroid_physiology0.71391370
86MP0003448_altered_tumor_morphology0.71322172
87MP0003186_abnormal_redox_activity0.68860833
88MP0001765_abnormal_ion_homeostasis0.68438352
89MP0005253_abnormal_eye_physiology0.65973138
90MP0005636_abnormal_mineral_homeostasis0.64022734
91MP0005377_hearing/vestibular/ear_phenot0.63830120
92MP0003878_abnormal_ear_physiology0.63830120
93MP0004142_abnormal_muscle_tone0.61853286
94MP0002210_abnormal_sex_determination0.61414945
95MP0001929_abnormal_gametogenesis0.61222005
96MP0003638_abnormal_response/metabolism_0.60929381
97MP0004947_skin_inflammation0.60230332
98MP0004742_abnormal_vestibular_system0.59860986
99MP0008961_abnormal_basal_metabolism0.58851929
100MP0005551_abnormal_eye_electrophysiolog0.58535821

Predicted human phenotypes

RankGene SetZ-score
1IgG deficiency (HP:0004315)4.59604283
2Aplastic anemia (HP:0001915)4.40273205
3Severe combined immunodeficiency (HP:0004430)4.29022765
4Stomatitis (HP:0010280)4.20201213
5Abnormality of T cell number (HP:0011839)4.10976878
6T lymphocytopenia (HP:0005403)4.05363134
7Autoimmune hemolytic anemia (HP:0001890)3.86485340
8Combined immunodeficiency (HP:0005387)3.63112797
9Abnormality of T cells (HP:0002843)3.59553520
10Increased hepatocellular lipid droplets (HP:0006565)3.43851523
113-Methylglutaconic aciduria (HP:0003535)3.43538842
12Increased IgM level (HP:0003496)3.40224887
13Lipid accumulation in hepatocytes (HP:0006561)3.33625291
14Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.16273187
15IgM deficiency (HP:0002850)3.13388810
16Abnormality of eosinophils (HP:0001879)3.10174681
17Thyroiditis (HP:0100646)3.03800123
18Panhypogammaglobulinemia (HP:0003139)3.02676301
19Acute necrotizing encephalopathy (HP:0006965)3.02506429
20Abnormality of the prostate (HP:0008775)3.00060385
21Abnormality of B cell number (HP:0010975)2.98859274
22Abnormality of T cell physiology (HP:0011840)2.93847736
23Mitochondrial inheritance (HP:0001427)2.91316204
24Elevated erythrocyte sedimentation rate (HP:0003565)2.88318358
25Encephalitis (HP:0002383)2.88007339
26B lymphocytopenia (HP:0010976)2.86926503
27Hypoproteinemia (HP:0003075)2.85175213
28Chronic diarrhea (HP:0002028)2.82878648
29Abnormal delayed hypersensitivity skin test (HP:0002963)2.81794702
30Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.75262154
31Renal Fanconi syndrome (HP:0001994)2.73595034
32Increased CSF lactate (HP:0002490)2.65176312
33Stomach cancer (HP:0012126)2.62188497
34Recurrent bronchitis (HP:0002837)2.57493074
35Increased intramyocellular lipid droplets (HP:0012240)2.54801960
36Abnormal mitochondria in muscle tissue (HP:0008316)2.54634138
37Acute encephalopathy (HP:0006846)2.53892097
38Abnormal number of erythroid precursors (HP:0012131)2.53570982
39Exertional dyspnea (HP:0002875)2.52329327
40Pancytopenia (HP:0001876)2.50151470
41Chronic mucocutaneous candidiasis (HP:0002728)2.48420749
42Recurrent cutaneous fungal infections (HP:0011370)2.48420749
43Eosinophilia (HP:0001880)2.48295584
44Reticulocytopenia (HP:0001896)2.46824900
45Oral leukoplakia (HP:0002745)2.45992733
46Progressive macrocephaly (HP:0004481)2.45344467
47Abnormality of cells of the erythroid lineage (HP:0012130)2.45074593
48Renal cortical cysts (HP:0000803)2.39008854
49Agammaglobulinemia (HP:0004432)2.38999320
50Colon cancer (HP:0003003)2.34349422
51Hepatocellular necrosis (HP:0001404)2.29714544
52Carpal bone hypoplasia (HP:0001498)2.26234770
53Pancreatic cysts (HP:0001737)2.24419942
54Recurrent fungal infections (HP:0002841)2.21224412
55Increased muscle lipid content (HP:0009058)2.20478336
56Granulocytopenia (HP:0001913)2.17133669
57Leukocytosis (HP:0001974)2.16791657
58Type 2 muscle fiber atrophy (HP:0003554)2.16478517
59Congenital stationary night blindness (HP:0007642)2.14657682
60Hepatic necrosis (HP:0002605)2.14261767
61Abnormal biliary tract physiology (HP:0012439)2.14251154
62Bile duct proliferation (HP:0001408)2.14251154
63Abnormality of the pons (HP:0007361)2.12865564
64Increased serum lactate (HP:0002151)2.12000766
65Pulmonary infiltrates (HP:0002113)2.11467378
66Lymphopenia (HP:0001888)2.10263189
67Lymphoma (HP:0002665)2.08034994
68Recurrent viral infections (HP:0004429)2.07624534
69Abnormality of cells of the lymphoid lineage (HP:0012140)2.06977420
70Generalized aminoaciduria (HP:0002909)2.00328494
71Macrocytic anemia (HP:0001972)1.99093957
72IgA deficiency (HP:0002720)1.99047774
73Degeneration of anterior horn cells (HP:0002398)1.98929071
74Abnormality of the anterior horn cell (HP:0006802)1.98929071
75Testicular atrophy (HP:0000029)1.98387523
76Stenosis of the external auditory canal (HP:0000402)1.97730210
77Hypothermia (HP:0002045)1.96515389
78Meningitis (HP:0001287)1.93753315
79Cerebral edema (HP:0002181)1.92732888
80Hypoplasia of the pons (HP:0012110)1.92170123
81Mediastinal lymphadenopathy (HP:0100721)1.89114690
82Lactic acidosis (HP:0003128)1.85655504
83Methylmalonic acidemia (HP:0002912)1.85485990
84Hypoplasia of the thymus (HP:0000778)1.85347924
85Abnormality of the renal cortex (HP:0011035)1.85112763
86Aplasia/Hypoplasia of the spleen (HP:0010451)1.82890317
87Meckel diverticulum (HP:0002245)1.82601180
88Parakeratosis (HP:0001036)1.82419611
89Clubbing of toes (HP:0100760)1.82157547
90Abnormal albumin level (HP:0012116)1.81994323
91Hypoalbuminemia (HP:0003073)1.81994323
92Neutropenia (HP:0001875)1.80649945
93Pulmonary fibrosis (HP:0002206)1.79106905
94Ureteral stenosis (HP:0000071)1.78217279
95Muscle fiber atrophy (HP:0100295)1.78106899
96Autoimmune thrombocytopenia (HP:0001973)1.76877830
97Joint swelling (HP:0001386)1.76177795
98Asplenia (HP:0001746)1.76106701
99Cellular immunodeficiency (HP:0005374)1.75905167
100Ureteral obstruction (HP:0006000)1.75389344

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.71451354
2MST43.75723149
3TAOK33.36755562
4VRK23.00353052
5NUAK12.88307362
6BUB12.43083836
7MAP4K22.00856502
8ZAK2.00564992
9PASK1.95244898
10SRPK11.90821837
11KDR1.89696343
12TESK21.87566970
13TSSK61.82812023
14MAP4K11.80958853
15ITK1.79691837
16BCKDK1.60402170
17PBK1.60325017
18IKBKE1.55716937
19MAP3K141.55487493
20EIF2AK31.50931578
21TLK11.47052078
22VRK11.47045357
23GRK61.40604049
24CDK191.40043152
25FES1.38793982
26TEC1.38471414
27IKBKB1.35609639
28WNK31.18117605
29WEE11.15568524
30NEK11.08092676
31LCK1.07886228
32PRKCQ1.06466022
33STK161.03852718
34CAMKK21.01463508
35BMPR20.98431513
36BTK0.98294918
37TRIM280.97859286
38JAK10.96974954
39CDC70.96866547
40MAP3K120.95138385
41CDK80.94838068
42SYK0.91419913
43ADRBK20.90169347
44GRK10.89781493
45BCR0.89262186
46MKNK10.88793191
47STK240.88432321
48MAPKAPK50.86643901
49DYRK20.86466231
50STK100.85063971
51NLK0.84708829
52SIK30.83769981
53BRD40.83461854
54PLK30.77910410
55DAPK10.77194621
56EIF2AK20.75905531
57RPS6KA50.75292085
58LYN0.74872982
59PLK40.73875010
60MATK0.71106662
61MARK30.70991294
62CSK0.70216447
63BMPR1B0.69087170
64MAP3K40.68828462
65WNK40.67312543
66NME10.66671381
67BRSK20.66401515
68ALK0.64948840
69TBK10.60867457
70JAK30.59366698
71ATR0.59005860
72MKNK20.56667634
73PIK3CG0.56490812
74MAPK130.54322894
75TTK0.54220796
76TAF10.52368240
77KIT0.52150966
78TNK20.51724859
79TGFBR10.51368359
80CLK10.50960698
81TIE10.49918569
82EIF2AK10.49915434
83STK40.49321651
84IGF1R0.48200410
85AURKB0.48030163
86OXSR10.46713906
87NEK90.40516412
88RPS6KA40.38938312
89PLK10.38494237
90ZAP700.37843290
91CSNK2A20.36865134
92ERBB30.35618237
93IRAK40.34908252
94EPHA30.34581923
95CSNK2A10.34479512
96MAPKAPK30.34002000
97JAK20.33999286
98PIM10.33117904
99TNIK0.32607318
100DYRK30.31070733

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.87634285
2Autoimmune thyroid disease_Homo sapiens_hsa053203.76652576
3Proteasome_Homo sapiens_hsa030503.63657273
4Allograft rejection_Homo sapiens_hsa053303.57966751
5Asthma_Homo sapiens_hsa053103.36795888
6Graft-versus-host disease_Homo sapiens_hsa053323.31221110
7Ribosome_Homo sapiens_hsa030103.19319449
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.83982481
9Oxidative phosphorylation_Homo sapiens_hsa001902.70975164
10Protein export_Homo sapiens_hsa030602.51695947
11Type I diabetes mellitus_Homo sapiens_hsa049402.44573901
12Parkinsons disease_Homo sapiens_hsa050122.42605968
13Antigen processing and presentation_Homo sapiens_hsa046122.30016195
14RNA polymerase_Homo sapiens_hsa030202.17223851
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.10482109
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.93326467
17T cell receptor signaling pathway_Homo sapiens_hsa046601.88857572
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.82356260
19Homologous recombination_Homo sapiens_hsa034401.71517078
20Basal transcription factors_Homo sapiens_hsa030221.68417237
21DNA replication_Homo sapiens_hsa030301.65867428
22RNA degradation_Homo sapiens_hsa030181.60970620
23Mismatch repair_Homo sapiens_hsa034301.57142337
24Hematopoietic cell lineage_Homo sapiens_hsa046401.56240279
25Measles_Homo sapiens_hsa051621.54584245
26Spliceosome_Homo sapiens_hsa030401.50580306
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.40734306
28Huntingtons disease_Homo sapiens_hsa050161.39892376
29Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.37529529
30Fanconi anemia pathway_Homo sapiens_hsa034601.35778055
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.32471307
32Alzheimers disease_Homo sapiens_hsa050101.28366803
33Viral myocarditis_Homo sapiens_hsa054161.27367383
34Non-homologous end-joining_Homo sapiens_hsa034501.25152247
35Nucleotide excision repair_Homo sapiens_hsa034201.17308428
36Rheumatoid arthritis_Homo sapiens_hsa053231.13475056
37RNA transport_Homo sapiens_hsa030131.08442280
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.05602414
39NF-kappa B signaling pathway_Homo sapiens_hsa040641.01728858
40Phototransduction_Homo sapiens_hsa047440.98511983
41Herpes simplex infection_Homo sapiens_hsa051680.97964787
42Pyrimidine metabolism_Homo sapiens_hsa002400.97389287
43Epstein-Barr virus infection_Homo sapiens_hsa051690.95046423
44One carbon pool by folate_Homo sapiens_hsa006700.92241969
45Sulfur metabolism_Homo sapiens_hsa009200.89314734
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86780148
47Base excision repair_Homo sapiens_hsa034100.82809462
48Propanoate metabolism_Homo sapiens_hsa006400.82787256
49Cardiac muscle contraction_Homo sapiens_hsa042600.77479440
50RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.77280656
51Nitrogen metabolism_Homo sapiens_hsa009100.77207226
52Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.76802735
53NOD-like receptor signaling pathway_Homo sapiens_hsa046210.75395532
54Purine metabolism_Homo sapiens_hsa002300.70178625
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.68960486
56Leishmaniasis_Homo sapiens_hsa051400.66251663
57Jak-STAT signaling pathway_Homo sapiens_hsa046300.65919928
58p53 signaling pathway_Homo sapiens_hsa041150.64484361
59Vitamin B6 metabolism_Homo sapiens_hsa007500.61417989
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60725674
61Staphylococcus aureus infection_Homo sapiens_hsa051500.57619260
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55109316
63Selenocompound metabolism_Homo sapiens_hsa004500.54545568
64Cell cycle_Homo sapiens_hsa041100.51584821
65Linoleic acid metabolism_Homo sapiens_hsa005910.48902750
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.48554680
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.47979509
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.45477593
69Chemokine signaling pathway_Homo sapiens_hsa040620.44943403
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42376845
71HTLV-I infection_Homo sapiens_hsa051660.41125245
72Tryptophan metabolism_Homo sapiens_hsa003800.38988780
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38296337
74Caffeine metabolism_Homo sapiens_hsa002320.37845045
75Butanoate metabolism_Homo sapiens_hsa006500.36762221
76mRNA surveillance pathway_Homo sapiens_hsa030150.36208438
77Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.35682392
78Legionellosis_Homo sapiens_hsa051340.32808665
79Viral carcinogenesis_Homo sapiens_hsa052030.32447527
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32414991
81Peroxisome_Homo sapiens_hsa041460.31351158
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30427581
83Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.30160626
84Systemic lupus erythematosus_Homo sapiens_hsa053220.30014357
85Influenza A_Homo sapiens_hsa051640.29013911
86Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.28634194
87Toxoplasmosis_Homo sapiens_hsa051450.25032137
88Glutathione metabolism_Homo sapiens_hsa004800.24724973
89Apoptosis_Homo sapiens_hsa042100.23074070
90Shigellosis_Homo sapiens_hsa051310.21878967
91Collecting duct acid secretion_Homo sapiens_hsa049660.21831920
92Metabolic pathways_Homo sapiens_hsa011000.20286863
93Regulation of autophagy_Homo sapiens_hsa041400.18342055
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.15324401
95Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.14334479
96Malaria_Homo sapiens_hsa051440.11113290
97Oocyte meiosis_Homo sapiens_hsa041140.10883656
98B cell receptor signaling pathway_Homo sapiens_hsa046620.10087609
99TNF signaling pathway_Homo sapiens_hsa046680.09538560
100Olfactory transduction_Homo sapiens_hsa047400.09337546

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