HNRNPA1P18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1folic acid-containing compound biosynthetic process (GO:0009396)8.07552750
2purine nucleotide salvage (GO:0032261)6.99158930
3homocysteine metabolic process (GO:0050667)6.21429782
4regulation of plasminogen activation (GO:0010755)6.19716464
5RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)6.16828198
6tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)6.16828198
7pteridine-containing compound biosynthetic process (GO:0042559)5.48714613
8regulation of gonadotropin secretion (GO:0032276)5.46928461
9protein-cofactor linkage (GO:0018065)5.35937967
10sulfur amino acid catabolic process (GO:0000098)5.32286377
11mitochondrial RNA metabolic process (GO:0000959)5.06487299
12epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)4.80802257
13adenosine metabolic process (GO:0046085)4.80754926
14platelet dense granule organization (GO:0060155)4.60173911
15IMP biosynthetic process (GO:0006188)4.59746364
16GMP metabolic process (GO:0046037)4.52523465
17mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.37762887
18mitochondrial respiratory chain complex I assembly (GO:0032981)4.37762887
19NADH dehydrogenase complex assembly (GO:0010257)4.37762887
20negative regulation of DNA biosynthetic process (GO:2000279)4.30207696
21alternative mRNA splicing, via spliceosome (GO:0000380)4.26007477
22cysteine metabolic process (GO:0006534)4.20452180
23pseudouridine synthesis (GO:0001522)4.17208356
24iron-sulfur cluster assembly (GO:0016226)4.10126534
25metallo-sulfur cluster assembly (GO:0031163)4.10126534
26tetrahydrofolate metabolic process (GO:0046653)4.09890864
27folic acid-containing compound metabolic process (GO:0006760)4.06131692
28protein-chromophore linkage (GO:0018298)3.79104532
29purine-containing compound salvage (GO:0043101)3.75203285
30ribosome biogenesis (GO:0042254)3.75092469
31microtubule nucleation (GO:0007020)3.72718791
32protein complex biogenesis (GO:0070271)3.71988673
33proteasome assembly (GO:0043248)3.71193290
34DNA deamination (GO:0045006)3.70759268
35rRNA modification (GO:0000154)3.62536891
36nucleotide salvage (GO:0043173)3.62455867
37protein deneddylation (GO:0000338)3.61016390
38IMP metabolic process (GO:0046040)3.60591648
39tRNA modification (GO:0006400)3.58294894
40cullin deneddylation (GO:0010388)3.46734539
41galactose catabolic process (GO:0019388)3.44427534
42desmosome organization (GO:0002934)3.43725124
43positive regulation of endothelial cell differentiation (GO:0045603)3.41087727
44GPI anchor biosynthetic process (GO:0006506)3.38568275
45pteridine-containing compound metabolic process (GO:0042558)3.37848611
46organic cation transport (GO:0015695)3.36125757
47mitochondrial respiratory chain complex assembly (GO:0033108)3.35136539
48negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)3.34952780
49cytidine deamination (GO:0009972)3.34113413
50cytidine metabolic process (GO:0046087)3.34113413
51cytidine catabolic process (GO:0006216)3.34113413
52regulation of vitamin D biosynthetic process (GO:0060556)3.27156862
53rRNA methylation (GO:0031167)3.26850559
54aldehyde catabolic process (GO:0046185)3.24031565
55polyamine biosynthetic process (GO:0006596)3.23232514
56one-carbon metabolic process (GO:0006730)3.21208050
57white fat cell differentiation (GO:0050872)3.20859068
58serine family amino acid biosynthetic process (GO:0009070)3.19774071
59sulfur amino acid biosynthetic process (GO:0000097)3.19232314
60galactose metabolic process (GO:0006012)3.19197579
61inner mitochondrial membrane organization (GO:0007007)3.16253441
62response to gravity (GO:0009629)3.13527558
63L-serine metabolic process (GO:0006563)3.11468414
64negative regulation of Ras GTPase activity (GO:0034261)3.10009623
65guanosine-containing compound biosynthetic process (GO:1901070)3.04875471
66regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.03123548
67GPI anchor metabolic process (GO:0006505)3.02458151
68cartilage morphogenesis (GO:0060536)3.02037135
69primary amino compound metabolic process (GO:1901160)3.00032440
70negative regulation of telomerase activity (GO:0051974)2.99381099
71transcription from mitochondrial promoter (GO:0006390)2.97872934
72folic acid metabolic process (GO:0046655)2.97306393
73purine nucleobase biosynthetic process (GO:0009113)2.91495169
74regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.91086278
75polyamine metabolic process (GO:0006595)2.90807753
76tRNA processing (GO:0008033)2.90656845
77positive regulation of hair cycle (GO:0042635)2.87639779
78positive regulation of hair follicle development (GO:0051798)2.87639779
79regulation of vitamin metabolic process (GO:0030656)2.85592714
80cochlea development (GO:0090102)2.81548389
81viral mRNA export from host cell nucleus (GO:0046784)2.76022408
82cellular component biogenesis (GO:0044085)2.74410302
83regulation of endothelial cell differentiation (GO:0045601)2.73360252
84aminoglycoside antibiotic metabolic process (GO:0030647)2.71521308
85RNA modification (GO:0009451)2.70363521
86L-fucose catabolic process (GO:0042355)2.66225446
87fucose catabolic process (GO:0019317)2.66225446
88L-fucose metabolic process (GO:0042354)2.66225446
89regulation of sequestering of triglyceride (GO:0010889)2.62162855
90peptidyl-histidine modification (GO:0018202)2.61595392
91serine family amino acid catabolic process (GO:0009071)2.60943162
92RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.58426651
93pyrimidine ribonucleoside catabolic process (GO:0046133)2.58371193
94placenta development (GO:0001890)2.55601793
95DNA replication-dependent nucleosome assembly (GO:0006335)2.54552286
96DNA replication-dependent nucleosome organization (GO:0034723)2.54552286
97rRNA metabolic process (GO:0016072)2.53271328
98rRNA processing (GO:0006364)2.53170322
99energy coupled proton transport, down electrochemical gradient (GO:0015985)2.53099725
100ATP synthesis coupled proton transport (GO:0015986)2.53099725

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse9.51065684
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.03207909
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.78288489
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.57980896
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.43757485
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.41606966
7VDR_22108803_ChIP-Seq_LS180_Human3.32244417
8ELF1_17652178_ChIP-ChIP_JURKAT_Human3.04630578
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.98530302
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.90286792
11FOXP3_21729870_ChIP-Seq_TREG_Human2.38829977
12VDR_23849224_ChIP-Seq_CD4+_Human2.34594020
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.29884985
14CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.26275541
15CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.17936603
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.12186454
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.05054676
18SRF_21415370_ChIP-Seq_HL-1_Mouse1.96049803
19MYC_18555785_ChIP-Seq_MESCs_Mouse1.89931154
20EGR1_23403033_ChIP-Seq_LIVER_Mouse1.88959944
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.84921194
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.84854217
23STAT1_20625510_ChIP-Seq_HELA_Human1.72671964
24CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.71967074
25ZNF274_21170338_ChIP-Seq_K562_Hela1.70566645
26POU5F1_16153702_ChIP-ChIP_HESCs_Human1.63526366
27EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.61236503
28IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.60117446
29PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.59634338
30ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.56700718
31HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52820442
32GABP_19822575_ChIP-Seq_HepG2_Human1.51435401
33TP53_22573176_ChIP-Seq_HFKS_Human1.50581543
34PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.50530276
35EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.46182748
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.37318674
37RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.35453593
38YY1_22570637_ChIP-Seq_MALME-3M_Human1.30736468
39ELK1_19687146_ChIP-ChIP_HELA_Human1.30628131
40EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.29592446
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.28783961
42FUS_26573619_Chip-Seq_HEK293_Human1.26184661
43MYC_19030024_ChIP-ChIP_MESCs_Mouse1.22616892
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.22072978
45FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.21481122
46SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.21130956
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.19145756
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.18910578
49LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.16648391
50CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.16414819
51E2F7_22180533_ChIP-Seq_HELA_Human1.16338943
52P300_27268052_Chip-Seq_Bcells_Human1.15634668
53FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13332859
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.13332859
55NCOR_22424771_ChIP-Seq_293T_Human1.13036013
56TTF2_22483619_ChIP-Seq_HELA_Human1.12846840
57CDX2_22108803_ChIP-Seq_LS180_Human1.12055936
58EWS_26573619_Chip-Seq_HEK293_Human1.11343266
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06536634
60E2F1_18555785_ChIP-Seq_MESCs_Mouse1.05827499
61CREB1_15753290_ChIP-ChIP_HEK293T_Human1.03913846
62GATA3_26560356_Chip-Seq_TH2_Human1.03785616
63CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.03149274
64FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03082627
65HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.02967289
66XRN2_22483619_ChIP-Seq_HELA_Human1.02283359
67FOXH1_21741376_ChIP-Seq_ESCs_Human1.01652100
68PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98699071
69MYB_26560356_Chip-Seq_TH2_Human0.97286579
70NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.97197201
71MYC_19079543_ChIP-ChIP_MESCs_Mouse0.96666632
72MYC_18940864_ChIP-ChIP_HL60_Human0.94934171
73TAF2_19829295_ChIP-Seq_ESCs_Human0.93384381
74SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92009575
75FOXH1_21741376_ChIP-Seq_EPCs_Human0.91672181
76ER_23166858_ChIP-Seq_MCF-7_Human0.91375958
77YY1_21170310_ChIP-Seq_MESCs_Mouse0.91184584
78AR_20517297_ChIP-Seq_VCAP_Human0.90174522
79ERG_20517297_ChIP-Seq_VCAP_Human0.89985040
80CIITA_25753668_ChIP-Seq_RAJI_Human0.89736807
81THAP11_20581084_ChIP-Seq_MESCs_Mouse0.89285144
82PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.87509466
83BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.86577495
84IRF8_21731497_ChIP-ChIP_J774_Mouse0.86309208
85GATA3_21878914_ChIP-Seq_MCF-7_Human0.86239179
86MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.86018615
87NANOG_20526341_ChIP-Seq_ESCs_Human0.84945208
88P300_19829295_ChIP-Seq_ESCs_Human0.84849726
89GATA3_26560356_Chip-Seq_TH1_Human0.84371239
90OCT4_20526341_ChIP-Seq_ESCs_Human0.83673264
91CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83079168
92P53_21459846_ChIP-Seq_SAOS-2_Human0.83053487
93FLI1_21867929_ChIP-Seq_CD8_Mouse0.83047729
94SOX2_22085726_ChIP-Seq_NPCs_Mouse0.82673152
95ZNF263_19887448_ChIP-Seq_K562_Human0.80278153
96ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.79680665
97OCT1_27270436_Chip-Seq_PROSTATE_Human0.79237934
98ETS1_21867929_ChIP-Seq_TH2_Mouse0.78543976
99SPI1_23547873_ChIP-Seq_NB4_Human0.77634895
100E2F1_21310950_ChIP-Seq_MCF-7_Human0.77179764

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005646_abnormal_pituitary_gland5.08373691
2MP0000013_abnormal_adipose_tissue3.91999260
3MP0008995_early_reproductive_senescence3.88968607
4MP0005670_abnormal_white_adipose3.63995630
5MP0003724_increased_susceptibility_to3.52869379
6MP0005360_urolithiasis3.20798676
7MP0002163_abnormal_gland_morphology2.90383519
8MP0003806_abnormal_nucleotide_metabolis2.76606687
9MP0005645_abnormal_hypothalamus_physiol2.73987270
10MP0004147_increased_porphyrin_level2.70190984
11MP0002736_abnormal_nociception_after2.33474989
12MP0002138_abnormal_hepatobiliary_system2.22691555
13MP0005671_abnormal_response_to2.18369161
14MP0002938_white_spotting2.17988093
15MP0008058_abnormal_DNA_repair2.05622693
16MP0004885_abnormal_endolymph2.03499069
17MP0001661_extended_life_span2.00706755
18MP0008872_abnormal_physiological_respon1.99174931
19MP0003786_premature_aging1.92498041
20MP0003787_abnormal_imprinting1.92306853
21MP0002102_abnormal_ear_morphology1.79536416
22MP0001764_abnormal_homeostasis1.78842792
23MP0008875_abnormal_xenobiotic_pharmacok1.67148282
24MP0001968_abnormal_touch/_nociception1.66942788
25MP0003183_abnormal_peptide_metabolism1.62502069
26MP0005367_renal/urinary_system_phenotyp1.59739112
27MP0000516_abnormal_urinary_system1.59739112
28MP0000372_irregular_coat_pigmentation1.54565050
29MP0000647_abnormal_sebaceous_gland1.48898579
30MP0003878_abnormal_ear_physiology1.42113109
31MP0005377_hearing/vestibular/ear_phenot1.42113109
32MP0005332_abnormal_amino_acid1.41560624
33MP0004043_abnormal_pH_regulation1.40920739
34MP0009764_decreased_sensitivity_to1.38238081
35MP0005084_abnormal_gallbladder_morpholo1.37684806
36MP0006276_abnormal_autonomic_nervous1.35853426
37MP0006292_abnormal_olfactory_placode1.31510187
38MP0002876_abnormal_thyroid_physiology1.25354646
39MP0002148_abnormal_hypersensitivity_rea1.23706521
40MP0002139_abnormal_hepatobiliary_system1.22187996
41MP0005379_endocrine/exocrine_gland_phen1.20661729
42MP0000631_abnormal_neuroendocrine_gland1.20417799
43MP0000003_abnormal_adipose_tissue1.17760157
44MP0003186_abnormal_redox_activity1.17141451
45MP0002735_abnormal_chemical_nociception1.14605294
46MP0006072_abnormal_retinal_apoptosis1.14026237
47MP0005551_abnormal_eye_electrophysiolog1.12170049
48MP0004947_skin_inflammation1.09411379
49MP0001984_abnormal_olfaction1.06585515
50MP0001502_abnormal_circadian_rhythm1.06082888
51MP0002277_abnormal_respiratory_mucosa1.02919508
52MP0001800_abnormal_humoral_immune1.02088034
53MP0005636_abnormal_mineral_homeostasis1.01391785
54MP0000534_abnormal_ureter_morphology0.97632721
55MP0005085_abnormal_gallbladder_physiolo0.97522987
56MP0009643_abnormal_urine_homeostasis0.97494846
57MP0005164_abnormal_response_to0.96650356
58MP0009046_muscle_twitch0.94801676
59MP0002006_tumorigenesis0.93508343
60MP0003718_maternal_effect0.91366112
61MP0005000_abnormal_immune_tolerance0.88142809
62MP0001986_abnormal_taste_sensitivity0.86840720
63MP0003436_decreased_susceptibility_to0.85915637
64MP0005253_abnormal_eye_physiology0.84033165
65MP0001119_abnormal_female_reproductive0.83337231
66MP0001919_abnormal_reproductive_system0.81341605
67MP0003880_abnormal_central_pattern0.80023922
68MP0002733_abnormal_thermal_nociception0.78756707
69MP0002723_abnormal_immune_serum0.78314409
70MP0005389_reproductive_system_phenotype0.78258055
71MP0000750_abnormal_muscle_regeneration0.76771169
72MP0008469_abnormal_protein_level0.76507208
73MP0000613_abnormal_salivary_gland0.74814098
74MP0001905_abnormal_dopamine_level0.74483902
75MP0000383_abnormal_hair_follicle0.74234642
76MP0005319_abnormal_enzyme/_coenzyme0.74200019
77MP0004133_heterotaxia0.74021143
78MP0001845_abnormal_inflammatory_respons0.71852139
79MP0009785_altered_susceptibility_to0.71617296
80MP0002452_abnormal_antigen_presenting0.71022062
81MP0001765_abnormal_ion_homeostasis0.70595750
82MP0003936_abnormal_reproductive_system0.70571224
83MP0009697_abnormal_copulation0.69578733
84MP0000747_muscle_weakness0.68830597
85MP0003646_muscle_fatigue0.67792682
86MP0002396_abnormal_hematopoietic_system0.67601524
87MP0002160_abnormal_reproductive_system0.67335056
88MP0002095_abnormal_skin_pigmentation0.64666481
89MP0000639_abnormal_adrenal_gland0.64175652
90MP0001819_abnormal_immune_cell0.63982871
91MP0002420_abnormal_adaptive_immunity0.63689644
92MP0002132_abnormal_respiratory_system0.63669038
93MP0005376_homeostasis/metabolism_phenot0.63296514
94MP0006035_abnormal_mitochondrial_morpho0.63120255
95MP0000703_abnormal_thymus_morphology0.62901210
96MP0000627_abnormal_mammary_gland0.62884125
97MP0001756_abnormal_urination0.62561247
98MP0008873_increased_physiological_sensi0.62506363
99MP0001881_abnormal_mammary_gland0.62065694
100MP0003638_abnormal_response/metabolism_0.61557313

Predicted human phenotypes

RankGene SetZ-score
1Hyperalaninemia (HP:0003348)7.95096384
2Abnormality of pyruvate family amino acid metabolism (HP:0010915)7.95096384
3Abnormality of alanine metabolism (HP:0010916)7.95096384
4Constricted visual fields (HP:0001133)6.33329738
5Decreased electroretinogram (ERG) amplitude (HP:0000654)4.34099646
6Attenuation of retinal blood vessels (HP:0007843)4.03768052
7Congenital sensorineural hearing impairment (HP:0008527)3.90231722
8Absent rod-and cone-mediated responses on ERG (HP:0007688)3.74852792
9Spontaneous hematomas (HP:0007420)3.55665422
10Chronic otitis media (HP:0000389)3.40290460
11Abnormality of serum amino acid levels (HP:0003112)3.31143369
12Esophageal varix (HP:0002040)3.17823936
13Homocystinuria (HP:0002156)3.00502561
14Abnormality of homocysteine metabolism (HP:0010919)3.00502561
15Tetany (HP:0001281)2.96631665
16Abnormal umbilical cord blood vessels (HP:0011403)2.92294032
17Single umbilical artery (HP:0001195)2.92294032
18Abnormality of the fetal cardiovascular system (HP:0010948)2.92294032
19Abolished electroretinogram (ERG) (HP:0000550)2.86253418
20Brittle hair (HP:0002299)2.83825020
21Pigmentary retinal degeneration (HP:0001146)2.81534916
22Hyperuricemia (HP:0002149)2.81472239
23Increased purine levels (HP:0004368)2.81472239
24Abnormal rod and cone electroretinograms (HP:0008323)2.77325918
25Anorexia (HP:0002039)2.64464879
26Poor speech (HP:0002465)2.62091620
27Abnormality of sulfur amino acid metabolism (HP:0004339)2.56328088
28Elevated erythrocyte sedimentation rate (HP:0003565)2.54461145
29Patchy hypopigmentation of hair (HP:0011365)2.53586498
30White forelock (HP:0002211)2.52620948
31Chorioretinal atrophy (HP:0000533)2.50517821
32Abnormality of purine metabolism (HP:0004352)2.48359018
33Pulmonary embolism (HP:0002204)2.45463330
34Hypoplasia of the uterus (HP:0000013)2.40548193
35Hypomagnesemia (HP:0002917)2.36976207
36Aplasia/hypoplasia of the uterus (HP:0008684)2.35018577
37Hyperglycinemia (HP:0002154)2.33602091
38Reduced antithrombin III activity (HP:0001976)2.32991467
39Decreased subcutaneous fat (HP:0001002)2.30982212
40Increased serum pyruvate (HP:0003542)2.27845778
41Heterochromia iridis (HP:0001100)2.23888741
42Cortical visual impairment (HP:0100704)2.23507853
43Pendular nystagmus (HP:0012043)2.19455363
44Conjunctival telangiectasia (HP:0000524)2.18467148
45Increased serum lactate (HP:0002151)2.16109852
46Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.15823781
47Aplasia/Hypoplasia of the sacrum (HP:0008517)2.14206465
48Myopathic facies (HP:0002058)2.11763643
49Chronic hepatic failure (HP:0100626)2.09942954
50Abnormality of the pons (HP:0007361)2.08374751
51Oligomenorrhea (HP:0000876)2.06482541
52Abnormality of dental color (HP:0011073)2.05516195
53Lactic acidosis (HP:0003128)2.04700540
54Methylmalonic acidemia (HP:0002912)2.03106511
55Abnormality of the vasculature of the conjunctiva (HP:0008054)2.02935370
56Conjugated hyperbilirubinemia (HP:0002908)2.02270755
57True hermaphroditism (HP:0010459)1.97985901
58Mitochondrial inheritance (HP:0001427)1.97544189
59Potter facies (HP:0002009)1.95585078
60Facial shape deformation (HP:0011334)1.95585078
61IgG deficiency (HP:0004315)1.95078918
62Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.92624943
63Abnormality of DNA repair (HP:0003254)1.92507926
64Pancreatic fibrosis (HP:0100732)1.92363545
65Abnormal respiratory epithelium morphology (HP:0012253)1.91759701
66Abnormal respiratory motile cilium morphology (HP:0005938)1.91759701
67Granulocytopenia (HP:0001913)1.91478300
68Abnormality of glycolysis (HP:0004366)1.91253575
69Arthropathy (HP:0003040)1.88781310
70Birth length less than 3rd percentile (HP:0003561)1.87663634
71Myocardial infarction (HP:0001658)1.83168411
72Abnormality of nucleobase metabolism (HP:0010932)1.82944545
73Abnormality of the renal collecting system (HP:0004742)1.82868440
74Thrombophlebitis (HP:0004418)1.82773910
75Optic disc pallor (HP:0000543)1.82217092
76Abnormality of subcutaneous fat tissue (HP:0001001)1.80913342
77Insulin-resistant diabetes mellitus (HP:0000831)1.80282449
78Abnormality of magnesium homeostasis (HP:0004921)1.79512361
79Recurrent corneal erosions (HP:0000495)1.79336518
80Maternal diabetes (HP:0009800)1.79234512
81Hypoplastic left heart (HP:0004383)1.77337605
82Orthostatic hypotension (HP:0001278)1.76061669
83Biconcave vertebral bodies (HP:0004586)1.76038001
84Methylmalonic aciduria (HP:0012120)1.75284986
85Short tibia (HP:0005736)1.74395770
86Hyperphosphaturia (HP:0003109)1.73176832
87Hypoalphalipoproteinemia (HP:0003233)1.72803194
88Type II diabetes mellitus (HP:0005978)1.72269244
89Chronic sinusitis (HP:0011109)1.71094039
90Hypergonadotropic hypogonadism (HP:0000815)1.70859349
91Abnormality of eosinophils (HP:0001879)1.70081419
92Duplicated collecting system (HP:0000081)1.70042709
93Chronic diarrhea (HP:0002028)1.69956716
94Type II lissencephaly (HP:0007260)1.68515897
95Nausea (HP:0002018)1.68329522
96Type 2 muscle fiber atrophy (HP:0003554)1.67396495
97Increased CSF lactate (HP:0002490)1.67144979
98Acute necrotizing encephalopathy (HP:0006965)1.67101966
99Generalized aminoaciduria (HP:0002909)1.66768731
100Pustule (HP:0200039)1.65148667

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK6.92059373
2TLK16.68278182
3MAP4K24.25775871
4VRK12.56613937
5BCKDK2.46869804
6MAP2K32.32755999
7LMTK22.29241480
8VRK22.26826399
9TAOK32.17357616
10MAP3K32.00150838
11MST41.96051910
12TNK21.81843067
13RPS6KB21.75957222
14TSSK61.71113437
15NME21.64484402
16MAP4K11.61404506
17ADRBK21.43897187
18CDK81.33850031
19NTRK21.29624133
20MAPKAPK51.24977152
21JAK31.22345183
22CDK91.21879829
23NTRK11.19285885
24FGR1.11590258
25IKBKB1.06939747
26MAPKAPK31.06884210
27MKNK11.06505770
28CSNK1G30.94699654
29CSNK1G10.94360737
30SRPK10.94280064
31ADRBK10.92214385
32ACVR1B0.91265603
33CSNK1A1L0.90492632
34RPS6KA50.85323809
35SGK4940.85192022
36SGK2230.85192022
37ABL20.84902571
38EIF2AK30.84725913
39SCYL20.84222042
40PHKG20.82795805
41PHKG10.82795805
42IKBKE0.82614861
43MATK0.78490313
44SGK20.78256415
45TXK0.75625566
46DYRK20.75090030
47CSNK1A10.73006288
48GRK10.71412792
49AURKA0.71112310
50SYK0.69711343
51BUB10.68738605
52TIE10.68361571
53TNIK0.67528223
54PIM10.66403039
55DAPK20.65726815
56PRKCQ0.65236584
57NTRK30.62146206
58KDR0.61969690
59NEK60.61691596
60NUAK10.60623401
61TRPM70.60403660
62MAP2K10.58091325
63PKN10.56825498
64MAP3K140.56211438
65CSNK1G20.53596048
66GRK60.50811394
67OBSCN0.49956615
68MAPK130.48839052
69PLK30.48418442
70BMPR1B0.47335198
71PRKG20.47065859
72PRKD30.46854209
73CDK70.46481059
74PDK20.46084681
75GRK70.45318757
76AKT20.44852594
77EPHB20.43788910
78EPHA20.40256721
79FES0.39308990
80RIPK10.37604883
81ITK0.37484592
82ALK0.37211275
83EPHA30.36532138
84EIF2AK20.35802749
85INSRR0.35644808
86CSNK2A10.35641782
87RPS6KA40.34238395
88INSR0.33980089
89RPS6KB10.33504256
90CCNB10.33276540
91TRIM280.32761070
92SGK30.32087216
93GRK50.31194867
94PRKCA0.31106710
95ATR0.30410976
96TAF10.30383279
97OXSR10.30000036
98KIT0.29872767
99LYN0.27496219
100TEC0.26949866

Predicted pathways (KEGG)

RankGene SetZ-score
1One carbon pool by folate_Homo sapiens_hsa006704.87123196
2Proteasome_Homo sapiens_hsa030503.26933152
3Nitrogen metabolism_Homo sapiens_hsa009102.65520075
4Sulfur relay system_Homo sapiens_hsa041222.52948011
5Sulfur metabolism_Homo sapiens_hsa009202.44589867
6Oxidative phosphorylation_Homo sapiens_hsa001902.30081055
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.28199570
8Basal transcription factors_Homo sapiens_hsa030222.01166285
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.99765024
10RNA polymerase_Homo sapiens_hsa030201.98971524
11Maturity onset diabetes of the young_Homo sapiens_hsa049501.92815420
12Ribosome_Homo sapiens_hsa030101.88517089
13Collecting duct acid secretion_Homo sapiens_hsa049661.86192832
14Spliceosome_Homo sapiens_hsa030401.84969119
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.82110423
16Systemic lupus erythematosus_Homo sapiens_hsa053221.76010702
17Parkinsons disease_Homo sapiens_hsa050121.72315810
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.68931358
19RNA degradation_Homo sapiens_hsa030181.67113365
20Selenocompound metabolism_Homo sapiens_hsa004501.61445152
21Arginine biosynthesis_Homo sapiens_hsa002201.59672571
22Primary immunodeficiency_Homo sapiens_hsa053401.55260080
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.54071143
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.45556588
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.45411247
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.44249384
27Asthma_Homo sapiens_hsa053101.40102589
28Base excision repair_Homo sapiens_hsa034101.29184716
29Regulation of autophagy_Homo sapiens_hsa041401.27278713
30Folate biosynthesis_Homo sapiens_hsa007901.21442431
31Homologous recombination_Homo sapiens_hsa034401.21229881
32Graft-versus-host disease_Homo sapiens_hsa053321.20540607
33Protein export_Homo sapiens_hsa030601.18538916
34Peroxisome_Homo sapiens_hsa041461.17032298
35RNA transport_Homo sapiens_hsa030131.15554818
36Nucleotide excision repair_Homo sapiens_hsa034201.15358305
37Fanconi anemia pathway_Homo sapiens_hsa034601.09054849
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08954758
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.07965066
40Cyanoamino acid metabolism_Homo sapiens_hsa004601.07476530
41Propanoate metabolism_Homo sapiens_hsa006401.05497685
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.04566153
43Morphine addiction_Homo sapiens_hsa050321.01739158
44Intestinal immune network for IgA production_Homo sapiens_hsa046721.00551468
45Huntingtons disease_Homo sapiens_hsa050161.00104756
46Retinol metabolism_Homo sapiens_hsa008300.97340452
47Alzheimers disease_Homo sapiens_hsa050100.97295656
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.96386461
49Type I diabetes mellitus_Homo sapiens_hsa049400.95041890
50Phototransduction_Homo sapiens_hsa047440.94961377
51Antigen processing and presentation_Homo sapiens_hsa046120.92889368
52Vitamin digestion and absorption_Homo sapiens_hsa049770.92555843
53Galactose metabolism_Homo sapiens_hsa000520.91533861
54Rheumatoid arthritis_Homo sapiens_hsa053230.90823170
55Allograft rejection_Homo sapiens_hsa053300.90018254
56Purine metabolism_Homo sapiens_hsa002300.88291636
57DNA replication_Homo sapiens_hsa030300.86940008
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85486769
59Autoimmune thyroid disease_Homo sapiens_hsa053200.85363156
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84643600
61Alcoholism_Homo sapiens_hsa050340.84543416
62GABAergic synapse_Homo sapiens_hsa047270.81961817
63Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.81480134
64Other glycan degradation_Homo sapiens_hsa005110.79932375
65Vibrio cholerae infection_Homo sapiens_hsa051100.79229386
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78490699
67Mismatch repair_Homo sapiens_hsa034300.77810413
68Pyrimidine metabolism_Homo sapiens_hsa002400.77258933
69Nicotine addiction_Homo sapiens_hsa050330.75646097
70Linoleic acid metabolism_Homo sapiens_hsa005910.66163680
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65918717
72Biosynthesis of amino acids_Homo sapiens_hsa012300.62776661
73Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.62017364
74Serotonergic synapse_Homo sapiens_hsa047260.60218926
75Metabolic pathways_Homo sapiens_hsa011000.59763818
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.57113586
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56958771
78Olfactory transduction_Homo sapiens_hsa047400.55736538
79Hematopoietic cell lineage_Homo sapiens_hsa046400.55070392
80Butanoate metabolism_Homo sapiens_hsa006500.53648944
81Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.53093594
82Renin-angiotensin system_Homo sapiens_hsa046140.51480009
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50224028
84Caffeine metabolism_Homo sapiens_hsa002320.50007593
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.49742491
86NF-kappa B signaling pathway_Homo sapiens_hsa040640.49167042
87Circadian entrainment_Homo sapiens_hsa047130.48991142
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.48795437
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46651430
90Tryptophan metabolism_Homo sapiens_hsa003800.45372428
91Chemical carcinogenesis_Homo sapiens_hsa052040.44632823
92mRNA surveillance pathway_Homo sapiens_hsa030150.42429430
93Arginine and proline metabolism_Homo sapiens_hsa003300.41934062
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.40803983
95Fatty acid biosynthesis_Homo sapiens_hsa000610.39965972
96Epstein-Barr virus infection_Homo sapiens_hsa051690.38462254
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38046463
98Legionellosis_Homo sapiens_hsa051340.37278809
99Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.36058444
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35979384

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