HNRNPA1L2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)4.07344027
2protein deneddylation (GO:0000338)4.04412595
3cullin deneddylation (GO:0010388)4.03464178
4histone H2A acetylation (GO:0043968)3.82486340
5DNA double-strand break processing (GO:0000729)3.78089248
6proteasome assembly (GO:0043248)3.60641490
7rRNA modification (GO:0000154)3.38857881
8regulation of DNA endoreduplication (GO:0032875)3.37502696
9kinetochore assembly (GO:0051382)3.37100628
10neural tube formation (GO:0001841)3.36976516
11nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.36501930
12somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.35879424
13isotype switching (GO:0045190)3.35879424
14somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.35879424
15inositol phosphate catabolic process (GO:0071545)3.34197267
16non-recombinational repair (GO:0000726)3.31453205
17double-strand break repair via nonhomologous end joining (GO:0006303)3.31453205
18base-excision repair, AP site formation (GO:0006285)3.30836666
19rRNA methylation (GO:0031167)3.30629725
20DNA ligation (GO:0006266)3.29577525
21DNA damage response, detection of DNA damage (GO:0042769)3.28918375
22replication fork processing (GO:0031297)3.26716690
23centriole replication (GO:0007099)3.26551478
24exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.25886104
25synapsis (GO:0007129)3.19541449
26regulation of mitotic spindle checkpoint (GO:1903504)3.18862542
27regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.18862542
28resolution of meiotic recombination intermediates (GO:0000712)3.16711774
29DNA methylation involved in gamete generation (GO:0043046)3.12433169
30negative regulation of DNA-dependent DNA replication (GO:2000104)3.08240745
31kinetochore organization (GO:0051383)3.07063261
32peptidyl-histidine modification (GO:0018202)3.06016448
33chromatin remodeling at centromere (GO:0031055)3.03104468
34protein K6-linked ubiquitination (GO:0085020)3.00201961
35DNA catabolic process, exonucleolytic (GO:0000738)3.00049674
36CENP-A containing nucleosome assembly (GO:0034080)2.96089982
37DNA deamination (GO:0045006)2.94855332
38male meiosis (GO:0007140)2.94276521
39RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.94234830
40positive regulation of mitochondrial fission (GO:0090141)2.90985792
41transcription from mitochondrial promoter (GO:0006390)2.89424452
42recombinational repair (GO:0000725)2.88672854
43spliceosomal snRNP assembly (GO:0000387)2.88645836
44L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.88468162
45DNA integration (GO:0015074)2.88273451
46double-strand break repair via homologous recombination (GO:0000724)2.84250398
47inositol phosphate dephosphorylation (GO:0046855)2.83462742
48phosphorylated carbohydrate dephosphorylation (GO:0046838)2.83462742
49maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.82968925
50rRNA catabolic process (GO:0016075)2.81908511
51regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.81563950
52somatic cell DNA recombination (GO:0016444)2.74870320
53somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.74870320
54attachment of spindle microtubules to kinetochore (GO:0008608)2.73317370
55somatic diversification of immune receptors (GO:0002200)2.72852412
56histone exchange (GO:0043486)2.71916128
57response to pheromone (GO:0019236)2.71731113
58intraciliary transport (GO:0042073)2.69405031
59nucleotide-excision repair, DNA gap filling (GO:0006297)2.69213325
60protein-cofactor linkage (GO:0018065)2.66926947
61tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.66320602
62RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.66320602
63somatic hypermutation of immunoglobulin genes (GO:0016446)2.65131925
64somatic diversification of immune receptors via somatic mutation (GO:0002566)2.65131925
65secondary metabolite biosynthetic process (GO:0044550)2.64785355
66protein K11-linked deubiquitination (GO:0035871)2.62589034
67positive regulation of histone H3-K4 methylation (GO:0051571)2.61279835
68adenosine metabolic process (GO:0046085)2.60308152
69L-fucose catabolic process (GO:0042355)2.59013501
70fucose catabolic process (GO:0019317)2.59013501
71L-fucose metabolic process (GO:0042354)2.59013501
72protein polyglutamylation (GO:0018095)2.56953544
73somatic recombination of immunoglobulin gene segments (GO:0016447)2.56492224
74histone mRNA metabolic process (GO:0008334)2.56443001
75somite development (GO:0061053)2.56037015
76somatic diversification of immunoglobulins (GO:0016445)2.55818747
77negative regulation of mRNA processing (GO:0050686)2.55662661
78positive regulation of granulocyte differentiation (GO:0030854)2.53054976
79polyol catabolic process (GO:0046174)2.53006705
80V(D)J recombination (GO:0033151)2.49500033
81cornea development in camera-type eye (GO:0061303)2.48946186
82mitochondrial RNA metabolic process (GO:0000959)2.48872259
83double-strand break repair (GO:0006302)2.48384833
84mitotic spindle checkpoint (GO:0071174)2.48153489
85respiratory chain complex IV assembly (GO:0008535)2.48085394
86DNA recombination (GO:0006310)2.47936500
87transcription elongation from RNA polymerase III promoter (GO:0006385)2.47229037
88termination of RNA polymerase III transcription (GO:0006386)2.47229037
89ncRNA catabolic process (GO:0034661)2.45850719
90cell wall macromolecule catabolic process (GO:0016998)2.45821553
91spindle checkpoint (GO:0031577)2.45532056
92melanin biosynthetic process (GO:0042438)2.45232780
93regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.44846124
94transcription elongation from RNA polymerase I promoter (GO:0006362)2.44759826
95melanin metabolic process (GO:0006582)2.44689095
96regulation of mRNA splicing, via spliceosome (GO:0048024)2.43996392
97histone mRNA catabolic process (GO:0071044)2.42881432
98L-methionine salvage (GO:0071267)2.40627658
99L-methionine biosynthetic process (GO:0071265)2.40627658
100amino acid salvage (GO:0043102)2.40627658

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.08437653
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.67055281
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.30522441
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.27412750
5ZNF274_21170338_ChIP-Seq_K562_Hela2.99575815
6IGF1R_20145208_ChIP-Seq_DFB_Human2.87066471
7ELF1_17652178_ChIP-ChIP_JURKAT_Human2.85147937
8* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.82325590
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.77203446
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.69957412
11* VDR_23849224_ChIP-Seq_CD4+_Human2.62706854
12PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.57760128
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.55596920
14ELK1_19687146_ChIP-ChIP_HELA_Human2.52936423
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.36154862
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.34809048
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.33911275
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.21196131
19E2F7_22180533_ChIP-Seq_HELA_Human2.19988390
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.18840228
21* FOXP3_21729870_ChIP-Seq_TREG_Human2.16975150
22NOTCH1_21737748_ChIP-Seq_TLL_Human2.15564807
23FUS_26573619_Chip-Seq_HEK293_Human2.08326723
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.05867927
25FLI1_27457419_Chip-Seq_LIVER_Mouse2.04477297
26EWS_26573619_Chip-Seq_HEK293_Human1.95624025
27GBX2_23144817_ChIP-Seq_PC3_Human1.95427818
28FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.94109992
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.90703164
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86186864
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.83535833
32PADI4_21655091_ChIP-ChIP_MCF-7_Human1.82815694
33IRF1_19129219_ChIP-ChIP_H3396_Human1.81319495
34MYC_18940864_ChIP-ChIP_HL60_Human1.81252818
35FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.69160233
36SRF_21415370_ChIP-Seq_HL-1_Mouse1.67085575
37KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.62416095
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.59729169
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.55396840
40TAF15_26573619_Chip-Seq_HEK293_Human1.55334409
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54907689
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.54505140
43VDR_22108803_ChIP-Seq_LS180_Human1.54328556
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54099877
45GABP_19822575_ChIP-Seq_HepG2_Human1.53807171
46RBPJ_22232070_ChIP-Seq_NCS_Mouse1.52782340
47CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.46508771
48P300_19829295_ChIP-Seq_ESCs_Human1.46459457
49HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.45913476
50MYC_18555785_ChIP-Seq_MESCs_Mouse1.45374751
51CIITA_25753668_ChIP-Seq_RAJI_Human1.36592447
52ER_23166858_ChIP-Seq_MCF-7_Human1.35380426
53DCP1A_22483619_ChIP-Seq_HELA_Human1.33190222
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33179085
55TTF2_22483619_ChIP-Seq_HELA_Human1.32473184
56PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.29550321
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27728378
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26992432
59CBP_20019798_ChIP-Seq_JUKART_Human1.26992432
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.22378298
61YY1_21170310_ChIP-Seq_MESCs_Mouse1.19144697
62TP53_22573176_ChIP-Seq_HFKS_Human1.17210048
63PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12171720
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11094351
65GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10899972
66EZH2_27294783_Chip-Seq_NPCs_Mouse1.09615056
67NFE2_27457419_Chip-Seq_LIVER_Mouse1.07870853
68CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.07765947
69SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06452146
70EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06212688
71MYC_19030024_ChIP-ChIP_MESCs_Mouse1.05741031
72KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03259155
73MYCN_18555785_ChIP-Seq_MESCs_Mouse1.02229252
74POU5F1_16153702_ChIP-ChIP_HESCs_Human1.01578237
75SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00435077
76RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.00262936
77MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99542037
78THAP11_20581084_ChIP-Seq_MESCs_Mouse0.99095138
79MYC_18358816_ChIP-ChIP_MESCs_Mouse0.98543963
80NELFA_20434984_ChIP-Seq_ESCs_Mouse0.94455351
81TP63_19390658_ChIP-ChIP_HaCaT_Human0.93682923
82MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.93025047
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92354827
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92146100
85FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92141550
86FOXM1_23109430_ChIP-Seq_U2OS_Human0.91930649
87E2F1_21310950_ChIP-Seq_MCF-7_Human0.91775159
88CRX_20693478_ChIP-Seq_RETINA_Mouse0.91213024
89SMAD4_21799915_ChIP-Seq_A2780_Human0.90953528
90SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.90118223
91ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.90006386
92HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.89062860
93TOP2B_26459242_ChIP-Seq_MCF-7_Human0.88843296
94BCAT_22108803_ChIP-Seq_LS180_Human0.88348311
95KDM5A_27292631_Chip-Seq_BREAST_Human0.87115307
96ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.86756741
97AUTS2_25519132_ChIP-Seq_293T-REX_Human0.84849592
98* GATA3_26560356_Chip-Seq_TH2_Human0.84627662
99E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.84386284
100TCF4_22108803_ChIP-Seq_LS180_Human0.83636324

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology4.67960039
2MP0000372_irregular_coat_pigmentation4.49251106
3MP0008058_abnormal_DNA_repair3.73718932
4MP0010094_abnormal_chromosome_stability3.49668940
5MP0008877_abnormal_DNA_methylation3.37777016
6MP0005075_abnormal_melanosome_morpholog2.77756072
7MP0006292_abnormal_olfactory_placode2.54450469
8MP0006072_abnormal_retinal_apoptosis2.52777053
9MP0003693_abnormal_embryo_hatching2.45975798
10MP0008789_abnormal_olfactory_epithelium2.02426462
11MP0008057_abnormal_DNA_replication2.02120111
12MP0003718_maternal_effect1.86717696
13MP0003111_abnormal_nucleus_morphology1.83567587
14MP0000569_abnormal_digit_pigmentation1.82484234
15MP0001529_abnormal_vocalization1.77372190
16MP0003880_abnormal_central_pattern1.76136696
17MP0005253_abnormal_eye_physiology1.74859798
18MP0002095_abnormal_skin_pigmentation1.70552762
19MP0002751_abnormal_autonomic_nervous1.69625371
20MP0005645_abnormal_hypothalamus_physiol1.65823995
21MP0005394_taste/olfaction_phenotype1.61620897
22MP0005499_abnormal_olfactory_system1.61620897
23MP0003077_abnormal_cell_cycle1.60440260
24MP0005367_renal/urinary_system_phenotyp1.58873286
25MP0000516_abnormal_urinary_system1.58873286
26MP0002938_white_spotting1.55949175
27MP0005408_hypopigmentation1.49503438
28MP0003786_premature_aging1.47509184
29MP0004957_abnormal_blastocyst_morpholog1.46966589
30MP0000015_abnormal_ear_pigmentation1.46921331
31MP0008995_early_reproductive_senescence1.41814355
32MP0002234_abnormal_pharynx_morphology1.41391346
33MP0003787_abnormal_imprinting1.38937388
34MP0002736_abnormal_nociception_after1.37072128
35MP0005551_abnormal_eye_electrophysiolog1.31399767
36MP0004142_abnormal_muscle_tone1.29217887
37MP0006276_abnormal_autonomic_nervous1.26927818
38MP0003136_yellow_coat_color1.20584175
39MP0002163_abnormal_gland_morphology1.20104680
40MP0001929_abnormal_gametogenesis1.19372850
41MP0001986_abnormal_taste_sensitivity1.18911680
42MP0000465_gastrointestinal_hemorrhage1.18551072
43MP0002638_abnormal_pupillary_reflex1.18302217
44MP0005174_abnormal_tail_pigmentation1.17144971
45MP0003763_abnormal_thymus_physiology1.14496426
46MP0003121_genomic_imprinting1.14314944
47MP0009697_abnormal_copulation1.14253500
48MP0003195_calcinosis1.14201076
49MP0008007_abnormal_cellular_replicative1.13707156
50MP0005646_abnormal_pituitary_gland1.12954756
51MP0008932_abnormal_embryonic_tissue1.12562549
52MP0002210_abnormal_sex_determination1.12069902
53MP0001324_abnormal_eye_pigmentation1.11170534
54MP0008872_abnormal_physiological_respon1.09563402
55MP0002822_catalepsy1.09416635
56MP0001984_abnormal_olfaction1.09183357
57MP0006036_abnormal_mitochondrial_physio1.08398162
58MP0001968_abnormal_touch/_nociception1.02550493
59MP0000653_abnormal_sex_gland0.98834233
60MP0001293_anophthalmia0.98236906
61MP0001119_abnormal_female_reproductive0.96904325
62MP0003698_abnormal_male_reproductive0.96558056
63MP0001145_abnormal_male_reproductive0.96413076
64MP0005391_vision/eye_phenotype0.91098676
65MP0005379_endocrine/exocrine_gland_phen0.87811836
66MP0006035_abnormal_mitochondrial_morpho0.84853300
67MP0004885_abnormal_endolymph0.84836582
68MP0001919_abnormal_reproductive_system0.84332544
69MP0002396_abnormal_hematopoietic_system0.83716131
70MP0003890_abnormal_embryonic-extraembry0.83629233
71MP0005389_reproductive_system_phenotype0.83544997
72MP0002233_abnormal_nose_morphology0.83329218
73MP0000703_abnormal_thymus_morphology0.80962359
74MP0000631_abnormal_neuroendocrine_gland0.80619504
75MP0000049_abnormal_middle_ear0.80320394
76MP0001486_abnormal_startle_reflex0.80214151
77MP0000371_diluted_coat_color0.80005922
78MP0003567_abnormal_fetal_cardiomyocyte0.79599217
79MP0003011_delayed_dark_adaptation0.79076822
80MP0003221_abnormal_cardiomyocyte_apopto0.75177433
81MP0002184_abnormal_innervation0.74930398
82MP0004381_abnormal_hair_follicle0.74753870
83MP0003186_abnormal_redox_activity0.73454969
84MP0001485_abnormal_pinna_reflex0.73448663
85MP0001835_abnormal_antigen_presentation0.71019033
86MP0001764_abnormal_homeostasis0.70907667
87MP0000689_abnormal_spleen_morphology0.68209368
88MP0005671_abnormal_response_to0.67749180
89MP0000427_abnormal_hair_cycle0.67073238
90MP0002752_abnormal_somatic_nervous0.65696963
91MP0001905_abnormal_dopamine_level0.65589959
92MP0002272_abnormal_nervous_system0.64849020
93MP0000778_abnormal_nervous_system0.64796631
94MP0000358_abnormal_cell_content/0.64436800
95MP0003943_abnormal_hepatobiliary_system0.64097565
96MP0002019_abnormal_tumor_incidence0.63198689
97MP0002090_abnormal_vision0.62933586
98MP0004742_abnormal_vestibular_system0.62005117
99MP0009745_abnormal_behavioral_response0.61581071
100MP0005195_abnormal_posterior_eye0.60721051

Predicted human phenotypes

RankGene SetZ-score
1Severe combined immunodeficiency (HP:0004430)3.69964730
2Abnormality of the labia minora (HP:0012880)3.69852884
3Volvulus (HP:0002580)3.16153111
4Thyroiditis (HP:0100646)3.14850730
5Combined immunodeficiency (HP:0005387)3.09693722
6Intestinal atresia (HP:0011100)3.07736138
7B lymphocytopenia (HP:0010976)3.05078364
8True hermaphroditism (HP:0010459)3.03875291
9Molar tooth sign on MRI (HP:0002419)2.83101031
10Abnormality of midbrain morphology (HP:0002418)2.83101031
11Abnormality of B cell number (HP:0010975)2.77711351
12Panhypogammaglobulinemia (HP:0003139)2.75577307
13Pancreatic cysts (HP:0001737)2.68820400
14Medial flaring of the eyebrow (HP:0010747)2.61031424
15Abnormality of chromosome stability (HP:0003220)2.60949648
16Nephrogenic diabetes insipidus (HP:0009806)2.57551733
17Chromsome breakage (HP:0040012)2.55813052
18Chromosomal breakage induced by crosslinking agents (HP:0003221)2.55612471
19Aplasia/Hypoplasia of the uvula (HP:0010293)2.53679215
20IgG deficiency (HP:0004315)2.53579859
21Colon cancer (HP:0003003)2.53428134
22Methylmalonic acidemia (HP:0002912)2.45314629
23Congenital primary aphakia (HP:0007707)2.43972884
24Pancreatic fibrosis (HP:0100732)2.42522900
25Sloping forehead (HP:0000340)2.40776097
26Ependymoma (HP:0002888)2.35584177
27Nephronophthisis (HP:0000090)2.35523280
28Renal cortical cysts (HP:0000803)2.34459573
29Gait imbalance (HP:0002141)2.33290087
30Abnormality of the ileum (HP:0001549)2.30506297
31Meckel diverticulum (HP:0002245)2.25816646
32Abnormality of eosinophils (HP:0001879)2.21252149
33Increased hepatocellular lipid droplets (HP:0006565)2.17619907
34Increased CSF lactate (HP:0002490)2.11660368
35Abnormal lung lobation (HP:0002101)2.10356822
36Small intestinal stenosis (HP:0012848)2.09113595
37Duodenal stenosis (HP:0100867)2.09113595
38Pendular nystagmus (HP:0012043)2.06840550
39Mitochondrial inheritance (HP:0001427)2.05006159
40Abnormality of the preputium (HP:0100587)2.04327590
41Median cleft lip (HP:0000161)2.02345937
42Abnormal protein glycosylation (HP:0012346)2.01364225
43Abnormal glycosylation (HP:0012345)2.01364225
44Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.01364225
45Abnormal protein N-linked glycosylation (HP:0012347)2.01364225
46Hepatocellular necrosis (HP:0001404)2.00104029
47Hyperglycinemia (HP:0002154)1.99958522
48Abnormality of the renal medulla (HP:0100957)1.98822626
49Bifid tongue (HP:0010297)1.98346296
50Abnormality of the astrocytes (HP:0100707)1.98007651
51Astrocytoma (HP:0009592)1.98007651
52Lipid accumulation in hepatocytes (HP:0006561)1.96817269
53Abnormality of the renal cortex (HP:0011035)1.95751838
54Hypoplasia of the thymus (HP:0000778)1.94655795
55Astigmatism (HP:0000483)1.93389198
56Abnormality of macular pigmentation (HP:0008002)1.91407668
57Tubulointerstitial nephritis (HP:0001970)1.90662904
58Short 1st metacarpal (HP:0010034)1.89666512
59Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.89666512
60Long clavicles (HP:0000890)1.88851036
61Methylmalonic aciduria (HP:0012120)1.88264921
62Abnormality of the duodenum (HP:0002246)1.87888073
63Myelodysplasia (HP:0002863)1.87461554
64Abolished electroretinogram (ERG) (HP:0000550)1.87331957
65Acute necrotizing encephalopathy (HP:0006965)1.84972520
66Glioma (HP:0009733)1.84468658
67Postaxial foot polydactyly (HP:0001830)1.83793211
68Retinal dysplasia (HP:0007973)1.82412060
69Stomatitis (HP:0010280)1.81932227
70Abnormality of the fovea (HP:0000493)1.80068341
71Congenital stationary night blindness (HP:0007642)1.79272301
723-Methylglutaconic aciduria (HP:0003535)1.79160857
73Failure to thrive in infancy (HP:0001531)1.77955147
74Narrow forehead (HP:0000341)1.77016305
75Progressive inability to walk (HP:0002505)1.76265082
76Aplasia/Hypoplasia of the macula (HP:0008059)1.75013946
77Clubbing of toes (HP:0100760)1.74456065
78Gaze-evoked nystagmus (HP:0000640)1.74263398
79Broad foot (HP:0001769)1.73705427
80Abnormality of the metopic suture (HP:0005556)1.73677819
81Hypoplasia of the fovea (HP:0007750)1.72842797
82Aplasia/Hypoplasia of the fovea (HP:0008060)1.72842797
83Postaxial hand polydactyly (HP:0001162)1.72414137
84Hepatic necrosis (HP:0002605)1.71406155
85Increased serum lactate (HP:0002151)1.71152243
86Small hand (HP:0200055)1.71054716
87Hypoproteinemia (HP:0003075)1.70399517
88Absent rod-and cone-mediated responses on ERG (HP:0007688)1.70115323
89Increased intramyocellular lipid droplets (HP:0012240)1.69132482
90Adactyly (HP:0009776)1.68494480
91Albinism (HP:0001022)1.66976853
92Supernumerary spleens (HP:0009799)1.66683636
93Progressive microcephaly (HP:0000253)1.66313809
94Poor coordination (HP:0002370)1.66278559
95Genital tract atresia (HP:0001827)1.65612469
96Abnormal rod and cone electroretinograms (HP:0008323)1.64788908
97Oligodactyly (hands) (HP:0001180)1.64699244
98Eosinophilia (HP:0001880)1.63755379
99Atrophy/Degeneration involving motor neurons (HP:0007373)1.63544997
100Patellar aplasia (HP:0006443)1.63229175

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K25.45407133
2TRIM283.75835846
3EIF2AK32.72424698
4TAOK32.46859831
5NUAK12.26292696
6FRK2.23922945
7EIF2AK12.20228314
8SRPK12.10338399
9BCR2.02053837
10TXK2.01879115
11BMPR1B1.95860467
12ZAK1.87119629
13MAP3K41.76738068
14MKNK11.71521373
15MKNK21.71314661
16PLK31.70678537
17ERBB31.69926334
18WNK31.62288494
19MAPK131.59776228
20NEK11.57836551
21SIK31.51584265
22BUB11.47987847
23PINK11.46777602
24PLK21.46773283
25MST41.37692381
26PASK1.34599351
27WEE11.33601270
28VRK21.31135309
29MAP2K71.29852968
30BCKDK1.27834197
31VRK11.24687108
32BRD41.20186797
33ATR1.19496854
34RPS6KA41.19485164
35TAF11.14683692
36FLT31.13544449
37TSSK61.12299933
38PLK41.11885093
39NLK1.10470980
40GRK61.09931593
41MARK31.08290734
42EIF2AK21.00461245
43CSNK1G10.98490890
44BRSK20.97783607
45PLK10.97435559
46CCNB10.91184693
47CSNK1G30.90916670
48STK38L0.90404598
49TGFBR10.89116815
50CDC70.85581609
51DYRK20.83776015
52DYRK1A0.81999882
53PAK30.79414119
54DYRK30.78998317
55STK160.76428430
56CSNK1A1L0.75023234
57EPHA40.74808934
58ATM0.74524789
59CAMKK20.73639265
60TNK20.73004465
61CDK30.72262122
62ACVR1B0.66505052
63TTK0.66307803
64TEC0.65842145
65TNIK0.65394579
66CSNK1G20.65385360
67EPHA30.63311434
68ADRBK20.63252697
69OXSR10.60343656
70MAP4K10.59502473
71GRK10.57787335
72PBK0.57360972
73MINK10.55133598
74SIK20.54071416
75CHEK10.53029915
76WNK40.52900136
77AURKB0.52189523
78PTK2B0.51753089
79BMPR20.50640919
80GRK50.48504283
81CASK0.45143154
82STK390.43965189
83PRKCE0.41615143
84TIE10.41111568
85CDK80.37969340
86PIM10.37243106
87PRKCQ0.36532797
88KIT0.36271081
89CLK10.35524310
90CDK190.34835952
91CSNK1D0.34272796
92CHEK20.33260319
93ADRBK10.32611614
94CSNK2A10.31642272
95RPS6KA50.31640730
96CSNK1A10.30777663
97NME10.30498310
98KSR10.30304453
99CSNK2A20.30025310
100NTRK20.28410395

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034504.41788416
2Protein export_Homo sapiens_hsa030603.18411195
3Basal transcription factors_Homo sapiens_hsa030222.92041421
4Proteasome_Homo sapiens_hsa030502.90191816
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.84779072
6Homologous recombination_Homo sapiens_hsa034402.74979738
7RNA polymerase_Homo sapiens_hsa030202.72455388
8Fanconi anemia pathway_Homo sapiens_hsa034602.66457555
9Mismatch repair_Homo sapiens_hsa034302.61609789
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.56935589
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.55321410
12RNA degradation_Homo sapiens_hsa030182.39385019
13* Spliceosome_Homo sapiens_hsa030402.39174337
14Base excision repair_Homo sapiens_hsa034102.33309890
15DNA replication_Homo sapiens_hsa030302.28011679
16RNA transport_Homo sapiens_hsa030132.21318733
17Propanoate metabolism_Homo sapiens_hsa006402.14273839
18Nucleotide excision repair_Homo sapiens_hsa034202.00035842
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.86796307
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.85573063
21Primary immunodeficiency_Homo sapiens_hsa053401.75361911
22Regulation of autophagy_Homo sapiens_hsa041401.71054334
23Butanoate metabolism_Homo sapiens_hsa006501.55571004
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.51566073
25Phototransduction_Homo sapiens_hsa047441.51453479
26Parkinsons disease_Homo sapiens_hsa050121.47311860
27Pyrimidine metabolism_Homo sapiens_hsa002401.44964149
28Cell cycle_Homo sapiens_hsa041101.28111652
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.27168243
30Oocyte meiosis_Homo sapiens_hsa041141.26976426
31Fatty acid elongation_Homo sapiens_hsa000621.26430342
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.26010387
33Oxidative phosphorylation_Homo sapiens_hsa001901.25346777
34Purine metabolism_Homo sapiens_hsa002301.25028060
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.23564773
36mRNA surveillance pathway_Homo sapiens_hsa030151.21849822
37Circadian rhythm_Homo sapiens_hsa047101.21770850
38Caffeine metabolism_Homo sapiens_hsa002321.18803761
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.08912346
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.08084461
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.06136349
42Huntingtons disease_Homo sapiens_hsa050161.02627745
43Steroid biosynthesis_Homo sapiens_hsa001000.99164318
44p53 signaling pathway_Homo sapiens_hsa041150.95872082
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.91832249
46One carbon pool by folate_Homo sapiens_hsa006700.87204012
47Intestinal immune network for IgA production_Homo sapiens_hsa046720.86671625
48Peroxisome_Homo sapiens_hsa041460.85780754
49Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84196174
50Taste transduction_Homo sapiens_hsa047420.81457942
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75146077
52Ribosome_Homo sapiens_hsa030100.72729502
53Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.71107458
54Selenocompound metabolism_Homo sapiens_hsa004500.69959359
55Allograft rejection_Homo sapiens_hsa053300.68376874
56Autoimmune thyroid disease_Homo sapiens_hsa053200.62783338
57Asthma_Homo sapiens_hsa053100.60111544
58Epstein-Barr virus infection_Homo sapiens_hsa051690.59827097
59Sulfur metabolism_Homo sapiens_hsa009200.58919616
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53315951
61Olfactory transduction_Homo sapiens_hsa047400.53151140
62Type I diabetes mellitus_Homo sapiens_hsa049400.52429123
63Herpes simplex infection_Homo sapiens_hsa051680.50271139
64Collecting duct acid secretion_Homo sapiens_hsa049660.49505565
65Metabolic pathways_Homo sapiens_hsa011000.48498528
66Linoleic acid metabolism_Homo sapiens_hsa005910.46859648
67Pyruvate metabolism_Homo sapiens_hsa006200.44337059
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41839803
69Alzheimers disease_Homo sapiens_hsa050100.41284364
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40050387
71Nicotine addiction_Homo sapiens_hsa050330.39746720
72Nitrogen metabolism_Homo sapiens_hsa009100.38423250
73Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.35017399
74TGF-beta signaling pathway_Homo sapiens_hsa043500.33688898
75RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.30836596
76T cell receptor signaling pathway_Homo sapiens_hsa046600.30829867
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30285123
78Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.29691545
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.29337703
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.29149833
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28107674
82Ether lipid metabolism_Homo sapiens_hsa005650.28074183
83Fatty acid metabolism_Homo sapiens_hsa012120.26254912
84beta-Alanine metabolism_Homo sapiens_hsa004100.25920388
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.25728482
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24386011
87Graft-versus-host disease_Homo sapiens_hsa053320.23470820
88GABAergic synapse_Homo sapiens_hsa047270.22364865
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.22353056
90Carbon metabolism_Homo sapiens_hsa012000.20141210
91Tryptophan metabolism_Homo sapiens_hsa003800.19369143
92Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.18375572
93Wnt signaling pathway_Homo sapiens_hsa043100.18197388
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.17874658
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.17786849
96Amphetamine addiction_Homo sapiens_hsa050310.17582633
97Colorectal cancer_Homo sapiens_hsa052100.16941674
98Measles_Homo sapiens_hsa051620.15459847
99Hematopoietic cell lineage_Homo sapiens_hsa046400.14745926
100Folate biosynthesis_Homo sapiens_hsa007900.13970908

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