HNF1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a transcription factor required for the expression of several liver-specific genes. The encoded protein functions as a homodimer and binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Defects in this gene are a cause of maturity onset diabetes of the young type 3 (MODY3) and also can result in the appearance of hepatic adenomas. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.38081706
2L-phenylalanine catabolic process (GO:0006559)7.38081706
3L-phenylalanine metabolic process (GO:0006558)7.10825298
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.10825298
5aromatic amino acid family catabolic process (GO:0009074)6.59153332
6indole-containing compound catabolic process (GO:0042436)5.92773766
7indolalkylamine catabolic process (GO:0046218)5.92773766
8tryptophan catabolic process (GO:0006569)5.92773766
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.75254900
10glyoxylate metabolic process (GO:0046487)5.73106551
11kynurenine metabolic process (GO:0070189)5.67970136
12tryptophan metabolic process (GO:0006568)5.59687953
13cysteine metabolic process (GO:0006534)5.53953978
14intestinal absorption (GO:0050892)5.46064174
15bile acid biosynthetic process (GO:0006699)5.45018239
16urea metabolic process (GO:0019627)5.38703062
17urea cycle (GO:0000050)5.38703062
18sulfur amino acid catabolic process (GO:0000098)5.19432366
19epoxygenase P450 pathway (GO:0019373)5.08160053
20alpha-linolenic acid metabolic process (GO:0036109)5.05851776
21serine family amino acid catabolic process (GO:0009071)5.04976243
22high-density lipoprotein particle remodeling (GO:0034375)5.01742068
23lysine metabolic process (GO:0006553)4.96639551
24lysine catabolic process (GO:0006554)4.96639551
25nitrogen cycle metabolic process (GO:0071941)4.96001270
26negative regulation of fibrinolysis (GO:0051918)4.87617956
27fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.87035885
28homocysteine metabolic process (GO:0050667)4.83961459
29aromatic amino acid family metabolic process (GO:0009072)4.79725469
30low-density lipoprotein particle remodeling (GO:0034374)4.78884113
31peptidyl-glutamic acid carboxylation (GO:0017187)4.76572508
32protein carboxylation (GO:0018214)4.76572508
33plasma lipoprotein particle organization (GO:0071827)4.74478256
34bile acid metabolic process (GO:0008206)4.73294454
35regulation of fibrinolysis (GO:0051917)4.66506943
36protein-lipid complex assembly (GO:0065005)4.62299280
37complement activation, alternative pathway (GO:0006957)4.59849796
38regulation of protein activation cascade (GO:2000257)4.57901250
39alpha-amino acid catabolic process (GO:1901606)4.54657659
40regulation of cholesterol esterification (GO:0010872)4.48861847
41amino-acid betaine metabolic process (GO:0006577)4.48152593
42acylglycerol homeostasis (GO:0055090)4.46612441
43triglyceride homeostasis (GO:0070328)4.46612441
44imidazole-containing compound metabolic process (GO:0052803)4.46273848
45reverse cholesterol transport (GO:0043691)4.43977978
46tyrosine metabolic process (GO:0006570)4.43369216
47regulation of triglyceride catabolic process (GO:0010896)4.39503480
48protein-lipid complex subunit organization (GO:0071825)4.35453474
49drug catabolic process (GO:0042737)4.34582122
50drug transmembrane transport (GO:0006855)4.29781070
51negative regulation of sterol transport (GO:0032372)4.28948709
52negative regulation of cholesterol transport (GO:0032375)4.28948709
53plasma lipoprotein particle remodeling (GO:0034369)4.28063789
54protein-lipid complex remodeling (GO:0034368)4.28063789
55macromolecular complex remodeling (GO:0034367)4.28063789
56regulation of bile acid biosynthetic process (GO:0070857)4.28036985
57phospholipid efflux (GO:0033700)4.27011794
58regulation of complement activation (GO:0030449)4.25925228
59cellular amino acid catabolic process (GO:0009063)4.24728607
60cellular ketone body metabolic process (GO:0046950)4.24146377
61serine family amino acid metabolic process (GO:0009069)4.23373111
62indolalkylamine metabolic process (GO:0006586)4.22687951
63regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.22194077
64bile acid and bile salt transport (GO:0015721)4.21306686
65cellular modified amino acid catabolic process (GO:0042219)4.17652327
66glutamate metabolic process (GO:0006536)4.17231702
67intestinal cholesterol absorption (GO:0030299)4.14594462
68glycine metabolic process (GO:0006544)4.14140960
69coenzyme catabolic process (GO:0009109)4.14054154
70proline metabolic process (GO:0006560)4.12522476
71urate metabolic process (GO:0046415)4.11721387
72serine family amino acid biosynthetic process (GO:0009070)4.03586631
73amine catabolic process (GO:0009310)4.02853828
74cellular biogenic amine catabolic process (GO:0042402)4.02853828
75blood coagulation, intrinsic pathway (GO:0007597)4.02494712
76benzene-containing compound metabolic process (GO:0042537)3.96528935
77regulation of plasminogen activation (GO:0010755)3.94893441
78regulation of cholesterol homeostasis (GO:2000188)3.94890718
79cellular glucuronidation (GO:0052695)3.91275854
80cholesterol efflux (GO:0033344)3.89007883
81plasma lipoprotein particle clearance (GO:0034381)3.86571617
82arginine metabolic process (GO:0006525)3.83698547
83positive regulation of fatty acid biosynthetic process (GO:0045723)3.83177476
84short-chain fatty acid metabolic process (GO:0046459)3.80677718
85plasma lipoprotein particle assembly (GO:0034377)3.77979351
86diacylglycerol metabolic process (GO:0046339)3.72894031
87carboxylic acid catabolic process (GO:0046395)3.72695634
88organic acid catabolic process (GO:0016054)3.72695634
89exogenous drug catabolic process (GO:0042738)3.71086435
90cholesterol homeostasis (GO:0042632)3.69451661
91dicarboxylic acid biosynthetic process (GO:0043650)3.67383307
92ethanol oxidation (GO:0006069)3.66243754
93sterol homeostasis (GO:0055092)3.65549990
94ketone body metabolic process (GO:1902224)3.65084696
95aldehyde catabolic process (GO:0046185)3.63612815
96aspartate family amino acid catabolic process (GO:0009068)3.61606957
97acetyl-CoA metabolic process (GO:0006084)3.56978917
98fat-soluble vitamin biosynthetic process (GO:0042362)3.56020430
99positive regulation of triglyceride lipase activity (GO:0061365)3.54855208
100positive regulation of lipoprotein lipase activity (GO:0051006)3.54855208
101phospholipid homeostasis (GO:0055091)3.53685672
102drug transport (GO:0015893)3.53598236
1032-oxoglutarate metabolic process (GO:0006103)3.53115914
104glucuronate metabolic process (GO:0019585)3.52516508
105uronic acid metabolic process (GO:0006063)3.52516508
106cholesterol transport (GO:0030301)3.49276680
107sterol transport (GO:0015918)3.49276680
108flavonoid metabolic process (GO:0009812)3.48314917
109fatty acid beta-oxidation (GO:0006635)3.47117021
110lipoprotein metabolic process (GO:0042157)3.45563133
111purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.45509357
1123-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.45509357
113drug metabolic process (GO:0017144)3.45027670
114very-low-density lipoprotein particle assembly (GO:0034379)3.45003812
115fatty acid oxidation (GO:0019395)3.44348426
116transepithelial transport (GO:0070633)3.43511249
117monocarboxylic acid catabolic process (GO:0072329)3.42825401
118fibrinolysis (GO:0042730)3.42679893
119negative regulation of digestive system process (GO:0060457)3.31269752
120omega-hydroxylase P450 pathway (GO:0097267)3.29654556
121negative regulation of lipase activity (GO:0060192)3.26976054
122negative regulation of hemostasis (GO:1900047)3.26599518
123negative regulation of blood coagulation (GO:0030195)3.26599518
124phosphate ion homeostasis (GO:0055062)3.26467760
125trivalent inorganic anion homeostasis (GO:0072506)3.26467760
126regulation of cholesterol biosynthetic process (GO:0045540)3.25638565
127regulation of apoptotic cell clearance (GO:2000425)3.21516551
128phenylpropanoid metabolic process (GO:0009698)3.17960005
129peptidyl-glutamic acid modification (GO:0018200)3.16947982
130regulation of cholesterol metabolic process (GO:0090181)3.15629483
131acute-phase response (GO:0006953)3.13669249
132lipid homeostasis (GO:0055088)3.13158942
133ethanol metabolic process (GO:0006067)3.09924816
134negative regulation of protein activation cascade (GO:2000258)3.09835295
135angiotensin maturation (GO:0002003)3.08579652
136nephron tubule morphogenesis (GO:0072078)3.02620370
137nephron epithelium morphogenesis (GO:0072088)3.02620370
138protein activation cascade (GO:0072376)3.02090755
139negative regulation of coagulation (GO:0050819)3.01866380
140vitamin biosynthetic process (GO:0009110)3.00904590

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.09816801
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.02896062
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.41879783
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.32170325
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.03037227
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.66633600
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.56153706
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.92293766
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.76624082
10CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.02357142
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.72190137
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.29467345
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.20647655
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.2281269
15TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.97669409
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95822859
17ZNF274_21170338_ChIP-Seq_K562_Hela1.86643513
18* FOXA2_19822575_ChIP-Seq_HepG2_Human1.75563704
19CLOCK_20551151_ChIP-Seq_293T_Human1.70670586
20GATA1_22025678_ChIP-Seq_K562_Human1.57124161
21* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.56194815
22* HNF4A_19822575_ChIP-Seq_HepG2_Human1.54197100
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.52639031
24NANOG_20526341_ChIP-Seq_ESCs_Human1.42952244
25CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.42668813
26MYC_19829295_ChIP-Seq_ESCs_Human1.42016762
27RAC3_21632823_ChIP-Seq_H3396_Human1.37241400
28E2F1_20622854_ChIP-Seq_HELA_Human1.34634870
29VDR_22108803_ChIP-Seq_LS180_Human1.34572048
30ERA_21632823_ChIP-Seq_H3396_Human1.34418195
31OCT4_20526341_ChIP-Seq_ESCs_Human1.32640166
32PHF8_20622854_ChIP-Seq_HELA_Human1.31342571
33GATA4_25053715_ChIP-Seq_YYC3_Human1.29138164
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.26190798
35BCL6_27268052_Chip-Seq_Bcells_Human1.25132147
36SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.21770610
37P68_20966046_ChIP-Seq_HELA_Human1.20684298
38THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.19850258
39CTCF_20526341_ChIP-Seq_ESCs_Human1.19124246
40HTT_18923047_ChIP-ChIP_STHdh_Human1.17076712
41CTCF_27219007_Chip-Seq_Bcells_Human1.16282343
42ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16227381
43RXRA_24833708_ChIP-Seq_LIVER_Mouse1.15472749
44CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.14623949
45FOXH1_21741376_ChIP-Seq_ESCs_Human1.13941333
46NCOR_22424771_ChIP-Seq_293T_Human1.13807844
47ETV2_25802403_ChIP-Seq_MESCs_Mouse1.13207848
48IRF8_22096565_ChIP-ChIP_GC-B_Human1.11603891
49YY1_22570637_ChIP-Seq_MALME-3M_Human1.11422605
50ESR1_21235772_ChIP-Seq_MCF-7_Human1.09547825
51SOX2_21211035_ChIP-Seq_LN229_Human1.07796026
52GATA3_21878914_ChIP-Seq_MCF-7_Human1.07682552
53EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04857238
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.03460520
55FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03460520
56TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.00145740
57PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99275017
58P300_27268052_Chip-Seq_Bcells_Human0.98444247
59ESR2_21235772_ChIP-Seq_MCF-7_Human0.98298318
60IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.96464948
61STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.94649355
62FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.94533989
63SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94398713
64RARG_19884340_ChIP-ChIP_MEFs_Mouse0.94001879
65PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93577540
66TET1_21451524_ChIP-Seq_MESCs_Mouse0.93019943
67NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.92136193
68TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.92036280
69CDX2_20551321_ChIP-Seq_CACO-2_Human0.91480244
70* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.90154325
71RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.89117522
72GATA6_25053715_ChIP-Seq_YYC3_Human0.89086936
73KAP1_22055183_ChIP-Seq_ESCs_Mouse0.88586435
74SOX2_22085726_ChIP-Seq_NPCs_Mouse0.87262243
75EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.86185063
76HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.85433062
77ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.84581684
78DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.84416012
79AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.83804168
80RARA_24833708_ChIP-Seq_LIVER_Mouse0.83315264
81FOXH1_21741376_ChIP-Seq_EPCs_Human0.82853365
82* SA1_27219007_Chip-Seq_Bcells_Human0.82586330
83SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.82349109
84BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81181078
85FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.80739644
86NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.80626742
87GATA3_21867929_ChIP-Seq_CD8_Mouse0.79740732
88ERG_21242973_ChIP-ChIP_JURKAT_Human0.79615686
89P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.79364225
90ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.76634595
91FOXO3_23340844_ChIP-Seq_DLD1_Human0.75725889
92FOXA1_25552417_ChIP-Seq_VCAP_Human0.75625270
93SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.73543357
94LXR_22292898_ChIP-Seq_THP-1_Human0.72540469
95ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.72109829
96BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.71060904
97SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.70928664
98SALL4_18804426_ChIP-ChIP_XEN_Mouse0.70254563
99RARB_24833708_ChIP-Seq_LIVER_Mouse0.70020304
100RAD21_21589869_ChIP-Seq_MESCs_Mouse0.69969995
101SOX2_20726797_ChIP-Seq_SW620_Human0.68951850
102AUTS2_25519132_ChIP-Seq_293T-REX_Human0.66441087
103PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.65800891
104Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.64866724
105FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.64035144
106FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.60590726
107STAT3_1855785_ChIP-Seq_MESCs_Mouse0.60590350
108PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.59718677
109AR_20517297_ChIP-Seq_VCAP_Human0.59087979
110PPAR_26484153_Chip-Seq_NCI-H1993_Human0.58927069
111NRF2_20460467_ChIP-Seq_MEFs_Mouse0.58115788
112NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.58115788
113NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.57695426
114ESR1_15608294_ChIP-ChIP_MCF-7_Human0.57640949
115ZNF263_19887448_ChIP-Seq_K562_Human0.57628858
116CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.56683125
117* CEBPB_22108803_ChIP-Seq_LS180_Human0.56662431
118EGR1_19032775_ChIP-ChIP_M12_Human0.56309997
119STAT1_17558387_ChIP-Seq_HELA_Human0.56237117
120* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.55898686
121TP63_17297297_ChIP-ChIP_HaCaT_Human0.55787598
122MYC_19915707_ChIP-ChIP_AK7_Human0.55248582
123ESET_19884257_ChIP-Seq_ESCs_Mouse0.54583556
124ERG_20517297_ChIP-Seq_VCAP_Human0.51727069
125* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.50726502
126EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.50535839
127BCAT_22108803_ChIP-Seq_LS180_Human0.50223735
128RACK7_27058665_Chip-Seq_MCF-7_Human0.50110987
129EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.49746147
130TAF2_19829295_ChIP-Seq_ESCs_Human0.49427488
131CBP_21632823_ChIP-Seq_H3396_Human0.49155216
132* CDX2_22108803_ChIP-Seq_LS180_Human0.48302540
133PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.48111116
134GATA1_19941826_ChIP-Seq_K562_Human0.47837502
135GATA2_19941826_ChIP-Seq_K562_Human0.47609567
136GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.47455560
137STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.46353105
138PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.46341995
139BCOR_27268052_Chip-Seq_Bcells_Human0.45976685
140GATA3_24758297_ChIP-Seq_MCF-7_Human0.45854479
141PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.45638600
142CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.45113310
143GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.45037557
144ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.44800646
145P53_21459846_ChIP-Seq_SAOS-2_Human0.44707801
146LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.44140634

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.84766910
2MP0005360_urolithiasis7.52841785
3MP0005085_abnormal_gallbladder_physiolo5.98765490
4MP0005365_abnormal_bile_salt5.92238696
5MP0008875_abnormal_xenobiotic_pharmacok4.62881818
6MP0003252_abnormal_bile_duct3.94147018
7MP0003806_abnormal_nucleotide_metabolis3.74891817
8MP0003195_calcinosis3.31605639
9MP0010329_abnormal_lipoprotein_level3.25196000
10MP0005083_abnormal_biliary_tract3.08275006
11MP0001666_abnormal_nutrient_absorption3.07028318
12MP0009840_abnormal_foam_cell2.91808234
13* MP0005332_abnormal_amino_acid2.91053868
14MP0002138_abnormal_hepatobiliary_system2.65774188
15MP0000566_synostosis2.51772820
16MP0004019_abnormal_vitamin_homeostasis2.47078351
17MP0003122_maternal_imprinting2.30018651
18MP0002254_reproductive_system_inflammat2.07687161
19* MP0000609_abnormal_liver_physiology2.01383604
20* MP0002118_abnormal_lipid_homeostasis2.00537759
21MP0003868_abnormal_feces_composition1.99485296
22MP0003191_abnormal_cellular_cholesterol1.91091132
23MP0002876_abnormal_thyroid_physiology1.81599894
24MP0001764_abnormal_homeostasis1.80234895
25* MP0009643_abnormal_urine_homeostasis1.72156264
26* MP0005319_abnormal_enzyme/_coenzyme1.69026936
27MP0001986_abnormal_taste_sensitivity1.41790636
28MP0005584_abnormal_enzyme/coenzyme_acti1.38539108
29MP0005220_abnormal_exocrine_pancreas1.34063338
30MP0005451_abnormal_body_composition1.33568274
31MP0005084_abnormal_gallbladder_morpholo1.28170157
32MP0005551_abnormal_eye_electrophysiolog1.26433406
33MP0005647_abnormal_sex_gland1.26194667
34MP0005636_abnormal_mineral_homeostasis1.23635988
35MP0004043_abnormal_pH_regulation1.17877257
36MP0003186_abnormal_redox_activity1.12555188
37* MP0000598_abnormal_liver_morphology1.08868953
38MP0004147_increased_porphyrin_level1.07525834
39MP0009780_abnormal_chondrocyte_physiolo1.06925214
40MP0009697_abnormal_copulation1.06479399
41MP0002909_abnormal_adrenal_gland1.05744452
42MP0003705_abnormal_hypodermis_morpholog1.02409116
43* MP0002078_abnormal_glucose_homeostasis1.01236937
44MP0004264_abnormal_extraembryonic_tissu1.00618411
45MP0003172_abnormal_lysosome_physiology1.00428153
46MP0002089_abnormal_postnatal_growth/wei0.96938662
47MP0002928_abnormal_bile_duct0.96212107
48MP0001664_abnormal_digestion0.95841395
49MP0003878_abnormal_ear_physiology0.93487230
50MP0005377_hearing/vestibular/ear_phenot0.93487230
51* MP0001756_abnormal_urination0.89875987
52* MP0009642_abnormal_blood_homeostasis0.89101265
53MP0009764_decreased_sensitivity_to0.87417504
54MP0005379_endocrine/exocrine_gland_phen0.87280251
55MP0009763_increased_sensitivity_to0.83851859
56MP0003123_paternal_imprinting0.82804939
57* MP0008469_abnormal_protein_level0.81879017
58MP0005646_abnormal_pituitary_gland0.81504221
59MP0003136_yellow_coat_color0.81360206
60MP0001485_abnormal_pinna_reflex0.81234825
61MP0003656_abnormal_erythrocyte_physiolo0.80837344
62MP0006036_abnormal_mitochondrial_physio0.80778952
63MP0000604_amyloidosis0.80578944
64MP0005410_abnormal_fertilization0.80273707
65MP0003011_delayed_dark_adaptation0.79290753
66MP0005174_abnormal_tail_pigmentation0.79025657
67MP0003283_abnormal_digestive_organ0.77649292
68MP0002971_abnormal_brown_adipose0.77587279
69MP0003943_abnormal_hepatobiliary_system0.75335683
70MP0005334_abnormal_fat_pad0.75147370
71MP0005408_hypopigmentation0.74601088
72MP0005535_abnormal_body_temperature0.73941915
73MP0009765_abnormal_xenobiotic_induced0.73883077
74MP0005376_homeostasis/metabolism_phenot0.72782649
75* MP0002136_abnormal_kidney_physiology0.71920784
76MP0003121_genomic_imprinting0.70632315
77MP0001765_abnormal_ion_homeostasis0.69861898
78MP0002938_white_spotting0.69842426
79MP0005670_abnormal_white_adipose0.69375282
80MP0003638_abnormal_response/metabolism_0.68103926
81MP0004133_heterotaxia0.64671632
82* MP0001944_abnormal_pancreas_morphology0.62710943
83MP0003959_abnormal_lean_body0.62397403
84MP0005167_abnormal_blood-brain_barrier0.62302136
85MP0001661_extended_life_span0.62240750
86MP0005409_darkened_coat_color0.61382122
87MP0001324_abnormal_eye_pigmentation0.61032387
88MP0002638_abnormal_pupillary_reflex0.60814836
89MP0002693_abnormal_pancreas_physiology0.60422460
90MP0010234_abnormal_vibrissa_follicle0.60355401
91* MP0005448_abnormal_energy_balance0.59524837
92MP0003300_gastrointestinal_ulcer0.58777668
93* MP0003953_abnormal_hormone_level0.58446522
94MP0003119_abnormal_digestive_system0.56007626
95MP0010386_abnormal_urinary_bladder0.55329366
96MP0005266_abnormal_metabolism0.55150863
97MP0009379_abnormal_foot_pigmentation0.53251153
98MP0000639_abnormal_adrenal_gland0.51661316
99MP0000538_abnormal_urinary_bladder0.51035937
100MP0010368_abnormal_lymphatic_system0.51020802
101MP0009053_abnormal_anal_canal0.50215590
102MP0003567_abnormal_fetal_cardiomyocyte0.49664931
103MP0000685_abnormal_immune_system0.49456862
104MP0005395_other_phenotype0.49065958
105MP0003329_amyloid_beta_deposits0.48805578
106MP0004782_abnormal_surfactant_physiolog0.47741206
107MP0002796_impaired_skin_barrier0.47545908
108MP0006082_CNS_inflammation0.45674056
109MP0002132_abnormal_respiratory_system0.45632769
110MP0006292_abnormal_olfactory_placode0.44066839
111MP0002168_other_aberrant_phenotype0.43931706
112MP0003879_abnormal_hair_cell0.43806125
113MP0000013_abnormal_adipose_tissue0.43667413
114MP0000579_abnormal_nail_morphology0.43325738
115MP0002163_abnormal_gland_morphology0.41316674
116MP0000230_abnormal_systemic_arterial0.40053489
117MP0006035_abnormal_mitochondrial_morpho0.39727291
118MP0005195_abnormal_posterior_eye0.38439360
119MP0001346_abnormal_lacrimal_gland0.38188074
120MP0009672_abnormal_birth_weight0.37700219
121MP0009115_abnormal_fat_cell0.37445672
122MP0001845_abnormal_inflammatory_respons0.36455436
123MP0003183_abnormal_peptide_metabolism0.35567177
124MP0005666_abnormal_adipose_tissue0.34353973
125MP0003718_maternal_effect0.33797612
126MP0002837_dystrophic_cardiac_calcinosis0.33296079
127* MP0002970_abnormal_white_adipose0.33029412
128MP0008872_abnormal_physiological_respon0.32434185
129MP0005058_abnormal_lysosome_morphology0.32063871
130MP0001873_stomach_inflammation0.31683320
131MP0008874_decreased_physiological_sensi0.31440120
132MP0004130_abnormal_muscle_cell0.31252316
133MP0000613_abnormal_salivary_gland0.29883355
134MP0002135_abnormal_kidney_morphology0.29855525
135MP0003724_increased_susceptibility_to0.29574450
136MP0005464_abnormal_platelet_physiology0.29382620
137MP0005645_abnormal_hypothalamus_physiol0.28927138

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.11624456
2Intrahepatic cholestasis (HP:0001406)6.70951963
3Abnormality of monocarboxylic acid metabolism (HP:0010996)6.17838003
4Deep venous thrombosis (HP:0002625)6.13552456
5Hypobetalipoproteinemia (HP:0003563)5.72626442
6Xanthomatosis (HP:0000991)5.67247715
7Prolonged partial thromboplastin time (HP:0003645)5.47171010
8Abnormality of glutamine family amino acid metabolism (HP:0010902)4.86554603
9Hypoglycemic coma (HP:0001325)4.62534727
10Ketosis (HP:0001946)4.57820544
11Hyperlipoproteinemia (HP:0010980)4.54927258
12Hyperglycinuria (HP:0003108)4.44887592
13Hyperammonemia (HP:0001987)4.43989457
14Complement deficiency (HP:0004431)4.39874488
15Hyperglycinemia (HP:0002154)4.33449530
16Hemorrhage of the eye (HP:0011885)4.27889278
17Hypolipoproteinemia (HP:0010981)4.18967540
18Abnormality of serine family amino acid metabolism (HP:0010894)4.15047277
19Abnormality of glycine metabolism (HP:0010895)4.15047277
20Fat malabsorption (HP:0002630)4.09382006
21Abnormality of sulfur amino acid metabolism (HP:0004339)4.03841144
22Abnormality of aspartate family amino acid metabolism (HP:0010899)4.03649398
23Epidermoid cyst (HP:0200040)4.02496520
24Joint hemorrhage (HP:0005261)4.01816230
25Abnormality of the common coagulation pathway (HP:0010990)3.99209548
26Ketoacidosis (HP:0001993)3.89232474
27Conjugated hyperbilirubinemia (HP:0002908)3.88636767
28Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.76301414
29Gout (HP:0001997)3.72080595
30Abnormality of the intrinsic pathway (HP:0010989)3.71896976
31Abnormality of methionine metabolism (HP:0010901)3.59367950
32Hypoalphalipoproteinemia (HP:0003233)3.51442305
33Hypophosphatemic rickets (HP:0004912)3.48332368
34Abnormality of fatty-acid metabolism (HP:0004359)3.42374762
35Abnormality of pyrimidine metabolism (HP:0004353)3.41283895
36Abnormality of nucleobase metabolism (HP:0010932)3.39921776
37Abnormality of purine metabolism (HP:0004352)3.39240717
38Hypoglycemic seizures (HP:0002173)3.35534324
39Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.30444828
40Abnormality of complement system (HP:0005339)3.19068845
41Hyperbilirubinemia (HP:0002904)3.13897328
42Hypercholesterolemia (HP:0003124)3.12040278
43Hyperinsulinemic hypoglycemia (HP:0000825)3.01256828
44Widely patent fontanelles and sutures (HP:0004492)2.98039963
45Steatorrhea (HP:0002570)2.91511772
46Delayed CNS myelination (HP:0002188)2.91103059
47Metabolic acidosis (HP:0001942)2.85557264
48Late onset (HP:0003584)2.84596090
49Abnormality of serum amino acid levels (HP:0003112)2.83397493
50Abnormality of proline metabolism (HP:0010907)2.79594186
51Hydroxyprolinuria (HP:0003080)2.79594186
52Generalized aminoaciduria (HP:0002909)2.77887164
53Vaginal fistula (HP:0004320)2.77700565
54Hepatocellular carcinoma (HP:0001402)2.76829527
55Dicarboxylic aciduria (HP:0003215)2.76656238
56Abnormality of dicarboxylic acid metabolism (HP:0010995)2.76656238
57Facial shape deformation (HP:0011334)2.75859268
58Potter facies (HP:0002009)2.75859268
59Pigmentary retinal degeneration (HP:0001146)2.72038729
60Symptomatic seizures (HP:0011145)2.66661622
61Malnutrition (HP:0004395)2.64236964
62Vascular calcification (HP:0004934)2.61203029
63Lethargy (HP:0001254)2.59921078
64Proximal tubulopathy (HP:0000114)2.59687245
65Hyperuricemia (HP:0002149)2.56602285
66Increased purine levels (HP:0004368)2.56602285
67Skin nodule (HP:0200036)2.55251130
68Irritability (HP:0000737)2.49737362
69Enlarged kidneys (HP:0000105)2.49425894
70Myocardial infarction (HP:0001658)2.46166514
71Alkalosis (HP:0001948)2.45878672
72Abnormal gallbladder morphology (HP:0012437)2.43771647
73Abnormality of the vitreous humor (HP:0004327)2.40412880
74Hypochromic microcytic anemia (HP:0004840)2.39528089
75Acanthocytosis (HP:0001927)2.36838960
76Spontaneous abortion (HP:0005268)2.36714481
77Pancreatitis (HP:0001733)2.33552676
78Abnormal urine phosphate concentration (HP:0012599)2.32633825
79Cholelithiasis (HP:0001081)2.31971430
80Hyperphosphaturia (HP:0003109)2.31700927
81Megaloblastic anemia (HP:0001889)2.30449269
82Cardiovascular calcification (HP:0011915)2.28225162
83Pendular nystagmus (HP:0012043)2.27146744
84Systemic lupus erythematosus (HP:0002725)2.27033952
85Abnormality of vitamin B metabolism (HP:0004340)2.26052765
86Abnormality of urine glucose concentration (HP:0011016)2.24800292
87Glycosuria (HP:0003076)2.24800292
88Esophageal varix (HP:0002040)2.23105394
89Attenuation of retinal blood vessels (HP:0007843)2.22645625
90Mitral stenosis (HP:0001718)2.22021580
91Spastic diplegia (HP:0001264)2.19050422
92Cerebral edema (HP:0002181)2.17807484
93Neonatal onset (HP:0003623)2.16970879
94Vomiting (HP:0002013)2.16531453
95Rickets (HP:0002748)2.15368317
96Abnormal enzyme/coenzyme activity (HP:0012379)2.13701070
97Decreased central vision (HP:0007663)2.13351306
98Sensorimotor neuropathy (HP:0007141)2.12446231
99Brushfield spots (HP:0001088)2.11735250
100Abnormality of the vitamin B12 metabolism (HP:0004341)2.11224901
101Hypothermia (HP:0002045)2.08012213
102Delayed epiphyseal ossification (HP:0002663)2.07581699
103Opisthotonus (HP:0002179)2.06387744
104Congenital stationary night blindness (HP:0007642)2.02883148
105Confusion (HP:0001289)2.01315510
106Recurrent gram-negative bacterial infections (HP:0005420)1.99978417
107Abnormality of the gallbladder (HP:0005264)1.98240315
108Retinal atrophy (HP:0001105)1.97498202
109Menorrhagia (HP:0000132)1.97364007
110Focal segmental glomerulosclerosis (HP:0000097)1.96329432
111Arthropathy (HP:0003040)1.94998025
112Abnormality of endocrine pancreas physiology (HP:0012093)1.94716914
113Abnormality of the pancreatic islet cells (HP:0006476)1.94716914
114Abnormality of alkaline phosphatase activity (HP:0004379)1.93178861
115Mesangial abnormality (HP:0001966)1.92785168
116Nephritis (HP:0000123)1.92348996
117Nephrolithiasis (HP:0000787)1.92297709
118Glomerulonephritis (HP:0000099)1.92248937
119Abnormality of vitamin metabolism (HP:0100508)1.91722458
120Methylmalonic aciduria (HP:0012120)1.91358075
121Abnormality of alanine metabolism (HP:0010916)1.90566457
122Hyperalaninemia (HP:0003348)1.90566457
123Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.90566457
124* Hyperglycemia (HP:0003074)1.89373257
125Hypophosphatemia (HP:0002148)1.89328730
126Glomerulosclerosis (HP:0000096)1.87919295
127Cholecystitis (HP:0001082)1.86934441
128Abnormal gallbladder physiology (HP:0012438)1.86934441
129Poikilocytosis (HP:0004447)1.86588840
130Elevated alkaline phosphatase (HP:0003155)1.86252217
131Renal cortical cysts (HP:0000803)1.85109205
132Chorioretinal atrophy (HP:0000533)1.84719188
133Congenital sensorineural hearing impairment (HP:0008527)1.84374140
134Gingival bleeding (HP:0000225)1.83017878
135Rectovaginal fistula (HP:0000143)1.79630471
136Rectal fistula (HP:0100590)1.79630471
137Abnormal urine output (HP:0012590)1.78949822
138Decreased circulating renin level (HP:0003351)1.78741692

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.40690860
2ERN14.71003218
3FGFR44.21030327
4INSRR4.19533953
5STK393.59596745
6MAP4K23.58999441
7SIK13.37524734
8TAOK33.14389223
9ACVR1B3.06546007
10FRK2.41885296
11WNK42.33903881
12MAPK152.33106283
13WNK32.32586231
14ERBB42.27427616
15MST1R2.11707574
16PTK61.99657745
17PIK3CA1.99423868
18ADRBK21.83881145
19LATS11.83839751
20PIK3CG1.82102605
21IRAK31.77041920
22FLT31.63701553
23TLK11.63141843
24MAPK111.58527383
25TYK21.52767055
26MAP3K141.46558974
27EPHA31.46260929
28STK38L1.42897993
29ZAK1.39472843
30LMTK21.38554165
31PKN21.34900660
32TRIB31.34032770
33EPHA21.31744828
34EPHB11.26034950
35MAP3K31.25646945
36MUSK1.21633437
37MAPKAPK51.21253590
38WNK11.19547793
39PRKAA21.17322047
40DAPK21.16963802
41PTK21.15915779
42TBK11.11188515
43JAK21.10509897
44MAPKAPK31.09301861
45TYRO31.07203713
46MAP2K41.07202957
47MAP3K71.06337177
48MET1.05693227
49NEK91.03064696
50GRK61.02736545
51BMPR1B1.01313858
52EPHA40.98901453
53MAP2K20.97134564
54MAP3K100.96754039
55MAP3K20.96205125
56ERBB20.92161178
57EEF2K0.86317317
58PINK10.86231735
59TNIK0.84244964
60PRKCG0.83932662
61JAK10.82605130
62TXK0.81384861
63ABL20.80879056
64MST40.79827107
65PRKAA10.77965754
66MATK0.77958541
67IRAK10.77248926
68OXSR10.76781052
69NME10.75659968
70GSK3A0.75284361
71FGFR10.74207456
72BRSK20.72637532
73TRIM280.72450233
74PRKCZ0.71455911
75KDR0.68665821
76CASK0.68138756
77CDK80.65443893
78MAPK130.63500214
79PDK20.60457576
80MAP3K10.60182801
81PRKACG0.59552410
82RIPK10.59345659
83CHUK0.58914416
84FGFR30.58256263
85PRKACA0.57420609
86TIE10.55967797
87DYRK30.55260915
88PHKG10.55239669
89PHKG20.55239669
90IRAK40.54806882
91PASK0.54406604
92MTOR0.54136315
93CSF1R0.53694546
94CAMK2G0.52596985
95CSK0.51007432
96PDK10.50482285
97MAP3K40.50325711
98GRK10.50199938
99AKT30.49863458
100FGFR20.49756218
101MAP2K60.49704889
102NTRK30.48953239
103SGK30.48703403
104PRKCE0.48643002
105PAK30.48224695
106FER0.47928734
107PRKG20.47872717
108PRKG10.47718326
109DDR20.44537788
110NUAK10.44212326
111MAPK40.43858333
112CAMKK20.43499864
113EPHB20.43058853
114CSNK1D0.42283741
115MAP2K10.41010750
116IKBKE0.40276324
117ADRBK10.40023268
118PDGFRA0.39468873
119SGK2230.39158828
120SGK4940.39158828
121MAP3K110.38595969
122PDPK10.38548032
123CAMK1D0.37833192
124CSNK1E0.37314031
125PRKCQ0.37131170
126VRK10.37063222
127NLK0.36129527
128IRAK20.35747338
129IKBKB0.35694554
130CSNK1A10.35547053
131HIPK20.34911361
132MAP2K30.34264732
133IGF1R0.33481904
134SGK20.33360453
135SRC0.32621212
136PRKCI0.31773820
137NTRK10.31251569
138CDK60.30933120
139MAP4K10.30575782
140TNK20.27098191
141STK110.26772941
142MAP3K130.26238918
143CDK90.25828541
144PRKCA0.25055519
145RPS6KB10.24905724
146EGFR0.23420187
147ITK0.21354544
148PRKCD0.19312122
149CAMK40.17838496
150MAPK30.17253357
151SCYL20.17051939
152RET0.16223343
153ICK0.16031977

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.03205032
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.41439943
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.33119659
4Nitrogen metabolism_Homo sapiens_hsa009103.20289881
5Arginine biosynthesis_Homo sapiens_hsa002202.91684035
6Tryptophan metabolism_Homo sapiens_hsa003802.79670438
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.60027154
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.55072859
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.48206349
10Fatty acid degradation_Homo sapiens_hsa000712.44977952
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.34635828
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.34294210
13Complement and coagulation cascades_Homo sapiens_hsa046102.28317064
14Butanoate metabolism_Homo sapiens_hsa006502.26498749
15Histidine metabolism_Homo sapiens_hsa003402.14049599
16Peroxisome_Homo sapiens_hsa041462.06814295
17* Maturity onset diabetes of the young_Homo sapiens_hsa049502.03363077
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.97264150
19Propanoate metabolism_Homo sapiens_hsa006401.94465934
20Sulfur metabolism_Homo sapiens_hsa009201.78192278
21Selenocompound metabolism_Homo sapiens_hsa004501.77660630
22Cyanoamino acid metabolism_Homo sapiens_hsa004601.74988433
23PPAR signaling pathway_Homo sapiens_hsa033201.73579286
24Chemical carcinogenesis_Homo sapiens_hsa052041.71858822
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.70250858
26beta-Alanine metabolism_Homo sapiens_hsa004101.69889372
27Fatty acid metabolism_Homo sapiens_hsa012121.69516670
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.69397191
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.63479179
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.62798930
31Phenylalanine metabolism_Homo sapiens_hsa003601.61041994
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.56783154
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.55471382
34Folate biosynthesis_Homo sapiens_hsa007901.52911958
35Bile secretion_Homo sapiens_hsa049761.52563815
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.52248590
37Fat digestion and absorption_Homo sapiens_hsa049751.51880018
38Pyruvate metabolism_Homo sapiens_hsa006201.49055113
39Retinol metabolism_Homo sapiens_hsa008301.47939414
40Caffeine metabolism_Homo sapiens_hsa002321.46813824
41Starch and sucrose metabolism_Homo sapiens_hsa005001.40225924
42Tyrosine metabolism_Homo sapiens_hsa003501.35041114
43Staphylococcus aureus infection_Homo sapiens_hsa051501.33599516
44Vitamin digestion and absorption_Homo sapiens_hsa049771.31240730
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.31143497
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.27877014
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.24271212
48ABC transporters_Homo sapiens_hsa020101.23576111
49Biosynthesis of amino acids_Homo sapiens_hsa012301.16057555
50Fatty acid elongation_Homo sapiens_hsa000621.14428937
51Arginine and proline metabolism_Homo sapiens_hsa003301.12999866
52Carbon metabolism_Homo sapiens_hsa012001.10727763
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.06833417
54Steroid biosynthesis_Homo sapiens_hsa001001.04543390
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.96190387
56Sulfur relay system_Homo sapiens_hsa041220.90746280
57Lysine degradation_Homo sapiens_hsa003100.87484989
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81229219
59Glycerolipid metabolism_Homo sapiens_hsa005610.80008760
60Glutathione metabolism_Homo sapiens_hsa004800.78846014
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76205922
62Vitamin B6 metabolism_Homo sapiens_hsa007500.71422943
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71145091
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.70838219
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.69874884
66One carbon pool by folate_Homo sapiens_hsa006700.66708327
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.64303259
68Sphingolipid metabolism_Homo sapiens_hsa006000.62748380
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54813579
70Pentose phosphate pathway_Homo sapiens_hsa000300.52109159
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52079777
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51667684
73Metabolic pathways_Homo sapiens_hsa011000.48624788
74Galactose metabolism_Homo sapiens_hsa000520.46005445
75Linoleic acid metabolism_Homo sapiens_hsa005910.42463423
76Fructose and mannose metabolism_Homo sapiens_hsa000510.39927992
77N-Glycan biosynthesis_Homo sapiens_hsa005100.32426168
78Phototransduction_Homo sapiens_hsa047440.30726881
79Fatty acid biosynthesis_Homo sapiens_hsa000610.30681599
80Insulin resistance_Homo sapiens_hsa049310.27904814
81Oxidative phosphorylation_Homo sapiens_hsa001900.26564937
82Prion diseases_Homo sapiens_hsa050200.25858714
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.22337410
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.15778978
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.14520162
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.12684779
87Renin-angiotensin system_Homo sapiens_hsa046140.12567665
88Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.12452045
89Glucagon signaling pathway_Homo sapiens_hsa049220.11392681
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.11249013
91Insulin secretion_Homo sapiens_hsa049110.10953805
92Protein digestion and absorption_Homo sapiens_hsa049740.10660559
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.10123448
94Protein export_Homo sapiens_hsa030600.09691565
95Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.07593732
96Taste transduction_Homo sapiens_hsa047420.05863830
97Glycosaminoglycan degradation_Homo sapiens_hsa005310.04900226
98Arachidonic acid metabolism_Homo sapiens_hsa005900.03743998
99AMPK signaling pathway_Homo sapiens_hsa041520.00140600
100Ether lipid metabolism_Homo sapiens_hsa00565-0.1564594
101Hepatitis C_Homo sapiens_hsa05160-0.1411804
102Type II diabetes mellitus_Homo sapiens_hsa04930-0.1343529
103Insulin signaling pathway_Homo sapiens_hsa04910-0.1280862
104Lysosome_Homo sapiens_hsa04142-0.1274163
105Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1252534
106Pancreatic secretion_Homo sapiens_hsa04972-0.1215059
107Other glycan degradation_Homo sapiens_hsa00511-0.1055644
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0902374
109Regulation of autophagy_Homo sapiens_hsa04140-0.0616504
110Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0215162
111Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0207578
112Mineral absorption_Homo sapiens_hsa04978-0.0123223

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