HMX3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1primary amino compound metabolic process (GO:1901160)5.64453417
2serotonin metabolic process (GO:0042428)5.49018270
3positive regulation of interferon-gamma biosynthetic process (GO:0045078)5.31719766
4T-helper 1 type immune response (GO:0042088)5.22346129
5response to parathyroid hormone (GO:0071107)5.17627796
6post-embryonic morphogenesis (GO:0009886)5.11797256
7regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)5.06868411
8locomotory exploration behavior (GO:0035641)5.03711486
9cell migration in hindbrain (GO:0021535)4.87307552
10B cell receptor signaling pathway (GO:0050853)4.83198764
11regulation of respiratory gaseous exchange by neurological system process (GO:0002087)4.73485990
12cellular response to prostaglandin stimulus (GO:0071379)4.70148608
13regulation of B cell receptor signaling pathway (GO:0050855)4.70124959
14CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.66217905
15immunoglobulin mediated immune response (GO:0016064)4.61273629
16sympathetic nervous system development (GO:0048485)4.54662865
17vocalization behavior (GO:0071625)4.49678231
18diacylglycerol metabolic process (GO:0046339)4.40442485
19positive regulation of humoral immune response (GO:0002922)4.39893391
20regulation of interferon-gamma biosynthetic process (GO:0045072)4.37637856
21synaptic vesicle exocytosis (GO:0016079)4.36625624
22positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.33506419
23synaptic vesicle maturation (GO:0016188)4.28906268
24positive regulation of gamma-delta T cell activation (GO:0046645)4.26093615
25regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.09939052
26B cell homeostasis (GO:0001782)4.02553958
27dopamine transport (GO:0015872)4.01952791
28transmission of nerve impulse (GO:0019226)4.01128282
29T cell migration (GO:0072678)4.00706135
30exploration behavior (GO:0035640)3.96448669
31desmosome organization (GO:0002934)3.95612694
32B cell mediated immunity (GO:0019724)3.94497125
33regulation of short-term neuronal synaptic plasticity (GO:0048172)3.88288184
34dendritic spine morphogenesis (GO:0060997)3.87062599
35B cell proliferation (GO:0042100)3.82900480
36positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.82833180
37righting reflex (GO:0060013)3.81026389
38T cell lineage commitment (GO:0002360)3.76267283
39regulation of glutamate receptor signaling pathway (GO:1900449)3.71045674
40positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.68073264
41regulation of respiratory gaseous exchange (GO:0043576)3.67043100
42regulation of respiratory system process (GO:0044065)3.67042308
43body morphogenesis (GO:0010171)3.62561233
44interferon-gamma-mediated signaling pathway (GO:0060333)3.60803379
45modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.60421707
46positive regulation by organism of defense response of other organism involved in symbiotic interact3.60421707
47modulation by symbiont of host immune response (GO:0052553)3.60421707
48positive regulation by symbiont of host defense response (GO:0052509)3.60421707
49modulation by symbiont of host defense response (GO:0052031)3.60421707
50modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.60421707
51omega-hydroxylase P450 pathway (GO:0097267)3.59360898
52adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.58207863
53chromatin assembly (GO:0031497)3.57775381
54myeloid dendritic cell differentiation (GO:0043011)3.56922661
55catecholamine transport (GO:0051937)3.55972236
56positive regulation of alpha-beta T cell proliferation (GO:0046641)3.54803746
57positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.52434234
58ectodermal placode formation (GO:0060788)3.51636790
59response to prostaglandin E (GO:0034695)3.51116272
60positive regulation of B cell differentiation (GO:0045579)3.50658072
61proline transport (GO:0015824)3.49455746
62DNA unwinding involved in DNA replication (GO:0006268)3.49248294
63negative thymic T cell selection (GO:0045060)3.48997697
64antigen processing and presentation of endogenous antigen (GO:0019883)3.44321353
65innate immune response in mucosa (GO:0002227)3.44138621
66regulation of B cell apoptotic process (GO:0002902)3.42369094
67regulation of alpha-beta T cell proliferation (GO:0046640)3.39724013
68neuromuscular process controlling posture (GO:0050884)3.39595903
69adrenergic receptor signaling pathway (GO:0071875)3.38537363
70activation of MAPKKK activity (GO:0000185)3.38135734
71regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.34206501
72positive regulation of macrophage cytokine production (GO:0060907)3.33778984
73negative regulation of B cell apoptotic process (GO:0002903)3.31674775
74type I interferon signaling pathway (GO:0060337)3.31305384
75cellular response to type I interferon (GO:0071357)3.31305384
76antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.30986498
77response to type I interferon (GO:0034340)3.29347766
78positive regulation of male gonad development (GO:2000020)3.25954288
79negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.25830494
80positive regulation of immunoglobulin mediated immune response (GO:0002891)3.21838356
81positive regulation of B cell mediated immunity (GO:0002714)3.21838356
82dopaminergic neuron differentiation (GO:0071542)3.20702173
83myeloid dendritic cell activation (GO:0001773)3.20437041
84genetic imprinting (GO:0071514)3.18661974
85proline biosynthetic process (GO:0006561)3.16369934
86regulation of RNA export from nucleus (GO:0046831)3.15892705
87cochlea development (GO:0090102)3.15790565
88spliceosomal tri-snRNP complex assembly (GO:0000244)3.15765123
89regulation of male gonad development (GO:2000018)3.14968157
90mitotic sister chromatid segregation (GO:0000070)3.14089545
91regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.13917848
92thymic T cell selection (GO:0045061)3.13132391
93positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.12297497
94neuron cell-cell adhesion (GO:0007158)3.12006179
95mitotic chromosome condensation (GO:0007076)3.11729347
96protein localization to synapse (GO:0035418)3.09920562
97negative T cell selection (GO:0043383)3.08597490
98antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.08373920
99T cell costimulation (GO:0031295)3.07669228
100DNA strand elongation involved in DNA replication (GO:0006271)3.07659899
101cellular response to interleukin-15 (GO:0071350)3.07328734
102neurotransmitter catabolic process (GO:0042135)3.06833316
103regulation of histone H3-K9 methylation (GO:0051570)3.05846914
104cerebellar Purkinje cell differentiation (GO:0021702)3.05617145
105regulation of gamma-delta T cell activation (GO:0046643)3.05267254
106amine biosynthetic process (GO:0009309)3.05226532
107cellular biogenic amine biosynthetic process (GO:0042401)3.05226532
108lymphocyte costimulation (GO:0031294)3.03052863
109SMAD protein complex assembly (GO:0007183)3.02673995
110monoamine transport (GO:0015844)3.00505078
111regulation of interferon-beta biosynthetic process (GO:0045357)2.99856635
112regulation of B cell differentiation (GO:0045577)2.99425896
113DNA strand elongation (GO:0022616)2.95994799
114mucosal immune response (GO:0002385)2.93927810
115regulation of non-canonical Wnt signaling pathway (GO:2000050)2.93861155
116neurotransmitter transport (GO:0006836)2.93811965
117detection of bacterium (GO:0016045)2.92989616
118regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.92879381
119mitotic nuclear envelope disassembly (GO:0007077)2.92863988
120NIK/NF-kappaB signaling (GO:0038061)2.92560576
121negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.91703312
122regulation of glutamate secretion (GO:0014048)2.91450659
123cranial nerve morphogenesis (GO:0021602)2.90987667
124positive regulation of interferon-alpha production (GO:0032727)2.90364018
125formation of translation preinitiation complex (GO:0001731)2.88593000
126mating behavior (GO:0007617)2.87627840
127cytoskeletal anchoring at plasma membrane (GO:0007016)2.87569599
128positive regulation of synaptic transmission, GABAergic (GO:0032230)2.87559083
129peptidyl-arginine omega-N-methylation (GO:0035247)2.86751294
130nuclear pore complex assembly (GO:0051292)2.85416465
131neuron fate specification (GO:0048665)2.85385113
132ionotropic glutamate receptor signaling pathway (GO:0035235)2.84668153
133lymphocyte homeostasis (GO:0002260)2.84665375
134neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.84544735
135antibacterial humoral response (GO:0019731)2.84316818
136regulation of transmission of nerve impulse (GO:0051969)2.83431133
137positive regulation of cytokine biosynthetic process (GO:0042108)2.83007171
138neurotransmitter secretion (GO:0007269)2.82804750
139negative regulation of B cell proliferation (GO:0030889)2.82333990
140response to interleukin-15 (GO:0070672)2.82035733
141sister chromatid segregation (GO:0000819)2.81112483
142cellular response to interferon-gamma (GO:0071346)2.78394474
143positive thymic T cell selection (GO:0045059)2.78363562
144cAMP-mediated signaling (GO:0019933)2.77851349
145postsynaptic membrane organization (GO:0001941)2.76449426
146positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.76168693
147response to muramyl dipeptide (GO:0032495)2.75069281
148somatic diversification of immune receptors via somatic mutation (GO:0002566)2.73246666
149somatic hypermutation of immunoglobulin genes (GO:0016446)2.73246666
150cerebellar Purkinje cell layer development (GO:0021680)2.73165810
151dopamine receptor signaling pathway (GO:0007212)2.72693755
152regulation of translational fidelity (GO:0006450)2.71793987
153regulation of vesicle fusion (GO:0031338)2.71766170
154protein localization to chromosome, centromeric region (GO:0071459)2.71705982
155regulation of cAMP-dependent protein kinase activity (GO:2000479)2.71220301
156neuron maturation (GO:0042551)2.70859050
157regulation of B cell proliferation (GO:0030888)2.70793070
158phenol-containing compound biosynthetic process (GO:0046189)2.70492951
159telomere maintenance via semi-conservative replication (GO:0032201)2.70294489
160membrane disassembly (GO:0030397)2.70105199
161nuclear envelope disassembly (GO:0051081)2.70105199
162chaperone mediated protein folding requiring cofactor (GO:0051085)2.68411573
163cytidine catabolic process (GO:0006216)2.67961498
164cytidine deamination (GO:0009972)2.67961498
165cytidine metabolic process (GO:0046087)2.67961498
166multicellular organismal signaling (GO:0035637)2.67789348
167regulation of interferon-alpha production (GO:0032647)2.67371799
168response to prostaglandin (GO:0034694)2.66239829
169adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.65575148
170social behavior (GO:0035176)2.65375012
171intraspecies interaction between organisms (GO:0051703)2.65375012
172DNA replication initiation (GO:0006270)2.63446686
173regulation of type I interferon-mediated signaling pathway (GO:0060338)2.62446037
174glutamate secretion (GO:0014047)2.61734767
175auditory receptor cell differentiation (GO:0042491)2.61723095
176energy homeostasis (GO:0097009)2.60616708
177enteric nervous system development (GO:0048484)2.58900642
178cell communication involved in cardiac conduction (GO:0086065)2.58240693
179cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.57981052
180regulation of synaptic transmission, GABAergic (GO:0032228)2.57920033
181membrane hyperpolarization (GO:0060081)2.57822622
182behavioral response to cocaine (GO:0048148)2.56386054
183protein kinase C-activating G-protein coupled receptor signaling pathway (GO:0007205)2.55922029
184* inner ear morphogenesis (GO:0042472)2.55828280
185cell differentiation in hindbrain (GO:0021533)2.55457697
186calcium-mediated signaling using intracellular calcium source (GO:0035584)2.54412901
187regulation of synaptic vesicle exocytosis (GO:2000300)2.53313089
188positive regulation of synapse assembly (GO:0051965)2.50686064
189regulation of neurotransmitter levels (GO:0001505)2.50321715
190neuron recognition (GO:0008038)2.50282618
191sensory perception of mechanical stimulus (GO:0050954)2.49839492
192sensory perception of sound (GO:0007605)2.46840515
193negative regulation of synaptic transmission, GABAergic (GO:0032229)2.46714544
194axon extension (GO:0048675)2.46097502
195regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.45179329
196cellular response to catecholamine stimulus (GO:0071870)2.44490242
197cellular response to monoamine stimulus (GO:0071868)2.44490242
198chemosensory behavior (GO:0007635)2.44097868
199cellular response to lithium ion (GO:0071285)2.43784833

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.45734188
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.34589957
3EZH2_22144423_ChIP-Seq_EOC_Human4.28867386
4MYC_22102868_ChIP-Seq_BL_Human4.22710647
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.27969230
6* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.23916772
7VDR_21846776_ChIP-Seq_THP-1_Human3.19328494
8* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.16290651
9E2F4_17652178_ChIP-ChIP_JURKAT_Human3.05203746
10* RNF2_18974828_ChIP-Seq_MESCs_Mouse3.03786996
11* EZH2_18974828_ChIP-Seq_MESCs_Mouse3.03786996
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.99818169
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.99167714
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.97224307
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.92361381
16* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.91118259
17* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.87603492
18TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.84291974
19FOXM1_23109430_ChIP-Seq_U2OS_Human2.78757759
20* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.78733393
21* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.68447492
22CIITA_25753668_ChIP-Seq_RAJI_Human2.66915051
23IRF8_22096565_ChIP-ChIP_GC-B_Human2.66212606
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.55682873
25* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.55379230
26MYC_18555785_ChIP-Seq_MESCs_Mouse2.54887421
27EED_16625203_ChIP-ChIP_MESCs_Mouse2.52822856
28* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.47769452
29ERG_21242973_ChIP-ChIP_JURKAT_Human2.45289920
30* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.41900475
31DROSHA_22980978_ChIP-Seq_HELA_Human2.41615049
32* EZH2_27294783_Chip-Seq_ESCs_Mouse2.34122433
33* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.30963538
34FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.30905089
35RNF2_27304074_Chip-Seq_ESCs_Mouse2.28640367
36MAF_26560356_Chip-Seq_TH1_Human2.28006647
37IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.21323463
38CDX2_19796622_ChIP-Seq_MESCs_Mouse2.10977796
39NOTCH1_21737748_ChIP-Seq_TLL_Human2.04114546
40MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.02493936
41MYC_18358816_ChIP-ChIP_MESCs_Mouse2.00349328
42MYC_19030024_ChIP-ChIP_MESCs_Mouse1.97500815
43TP63_17297297_ChIP-ChIP_HaCaT_Human1.94105520
44GBX2_23144817_ChIP-Seq_PC3_Human1.93039693
45* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.92886926
46CREB1_15753290_ChIP-ChIP_HEK293T_Human1.87391220
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.87330063
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.85992489
49STAT4_19710469_ChIP-ChIP_TH1__Mouse1.85049026
50* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.82672307
51XRN2_22483619_ChIP-Seq_HELA_Human1.81772335
52MYC_19079543_ChIP-ChIP_MESCs_Mouse1.81325022
53REST_21632747_ChIP-Seq_MESCs_Mouse1.75963085
54NELFA_20434984_ChIP-Seq_ESCs_Mouse1.75681445
55VDR_22108803_ChIP-Seq_LS180_Human1.74966434
56SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.67829431
57ELF1_17652178_ChIP-ChIP_JURKAT_Human1.67675588
58POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.67621852
59SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.66860667
60REST_18959480_ChIP-ChIP_MESCs_Mouse1.65876525
61* CBX2_27304074_Chip-Seq_ESCs_Mouse1.65764918
62CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.65111359
63* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.65069056
64VDR_24763502_ChIP-Seq_THP-1_Human1.63491626
65MYB_26560356_Chip-Seq_TH1_Human1.61976029
66NR3C1_23031785_ChIP-Seq_PC12_Mouse1.61830132
67MAF_26560356_Chip-Seq_TH2_Human1.61517629
68UTX_26944678_Chip-Seq_JUKART_Human1.60285080
69E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.58811143
70KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.57351424
71MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.56271143
72ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.56188145
73ETS1_20019798_ChIP-Seq_JURKAT_Human1.55768540
74FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.55666841
75RING1B_27294783_Chip-Seq_ESCs_Mouse1.54837565
76JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.54378622
77HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.53491215
78DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.52743208
79TRIM28_21343339_ChIP-Seq_HEK293_Human1.52518328
80THAP11_20581084_ChIP-Seq_MESCs_Mouse1.52047242
81TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.51561640
82DCP1A_22483619_ChIP-Seq_HELA_Human1.50638150
83ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.49286021
84GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.48643667
85ERG_20887958_ChIP-Seq_HPC-7_Mouse1.47967994
86MYB_26560356_Chip-Seq_TH2_Human1.46967189
87* NCOR1_26117541_ChIP-Seq_K562_Human1.46422625
88* RNF2_27304074_Chip-Seq_NSC_Mouse1.46259999
89ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.45412255
90NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.43684491
91CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43029385
92CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.41859549
93YY1_21170310_ChIP-Seq_MESCs_Mouse1.41355811
94MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.41299349
95CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.41046484
96RING1B_27294783_Chip-Seq_NPCs_Mouse1.39919080
97VDR_23849224_ChIP-Seq_CD4+_Human1.39654460
98ZNF217_24962896_ChIP-Seq_MCF-7_Human1.38695855
99HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38094419
100KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.36863522
101TCF7_22412390_ChIP-Seq_EML_Mouse1.36462566
102KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.36113426
103NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.33776662
104SPI1_23547873_ChIP-Seq_NB4_Human1.31867252
105AR_21572438_ChIP-Seq_LNCaP_Human1.31060478
106CTBP2_25329375_ChIP-Seq_LNCAP_Human1.30159913
107P300_19829295_ChIP-Seq_ESCs_Human1.30120271
108DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.29417017
109TP53_18474530_ChIP-ChIP_U2OS_Human1.29195531
110TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.28582186
111FOXP3_21729870_ChIP-Seq_TREG_Human1.28403648
112NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.27765760
113* TP53_20018659_ChIP-ChIP_R1E_Mouse1.27300777
114CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.26116965
115IRF8_21731497_ChIP-ChIP_J774_Mouse1.25216017
116SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.25078032
117CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.24183341
118IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.21465542
119EST1_17652178_ChIP-ChIP_JURKAT_Human1.20872958
120KDM5A_27292631_Chip-Seq_BREAST_Human1.19614319
121* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.19400145
122BRD4_27068464_Chip-Seq_AML-cells_Mouse1.18636422
123DNAJC2_21179169_ChIP-ChIP_NT2_Human1.18520718
124TTF2_22483619_ChIP-Seq_HELA_Human1.18145438
125NANOG_18555785_ChIP-Seq_MESCs_Mouse1.15938285
126ZFP57_27257070_Chip-Seq_ESCs_Mouse1.14904490
127ELF1_20517297_ChIP-Seq_JURKAT_Human1.14735170
128WT1_19549856_ChIP-ChIP_CCG9911_Human1.14614559
129SMAD3_21741376_ChIP-Seq_EPCs_Human1.14307873
130ZFX_18555785_ChIP-Seq_MESCs_Mouse1.12653307
131E2F1_18555785_ChIP-Seq_MESCs_Mouse1.12620118
132CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.12431918
133KDM2B_26808549_Chip-Seq_DND41_Human1.11727559
134WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10499780
135STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.10055867
136SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.09652962
137MYCN_18555785_ChIP-Seq_MESCs_Mouse1.09029910
138SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.08305892
139GABP_19822575_ChIP-Seq_HepG2_Human1.08253178
140GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.07944743
141PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.06628482
142TFEB_21752829_ChIP-Seq_HELA_Human1.05769843
143OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.04506315
144WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.04125664
145ZFP281_27345836_Chip-Seq_ESCs_Mouse1.04082095
146* ELK3_25401928_ChIP-Seq_HUVEC_Human1.03364467
147* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.03000817
148PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.02938621
149GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02929882
150SMAD4_21799915_ChIP-Seq_A2780_Human1.02748672
151SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02415213
152* KDM2B_26808549_Chip-Seq_K562_Human1.01343583
153RUNX1_22412390_ChIP-Seq_EML_Mouse1.01023217
154GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00505107
155SOX2_21211035_ChIP-Seq_LN229_Gbm1.00454384
156SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99133619
157PIAS1_25552417_ChIP-Seq_VCAP_Human0.98852947
158CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.98218705
159RUNX2_22187159_ChIP-Seq_PCA_Human0.98192083
160* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97993006
161TAF15_26573619_Chip-Seq_HEK293_Human0.97322139
162NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.97189198
163CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97183523
164YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96484179
165* CTCF_27219007_Chip-Seq_Bcells_Human0.95384424
166GATA1_22025678_ChIP-Seq_K562_Human0.95271965
167AHR_22903824_ChIP-Seq_MCF-7_Human0.94293332
168RARB_27405468_Chip-Seq_BRAIN_Mouse0.93630992
169PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.92976501
170BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91880777
171ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.91577749
172ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91028688
173ARNT_22903824_ChIP-Seq_MCF-7_Human0.90101711
174EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.88993782
175* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.88624429
176* SMAD3_21741376_ChIP-Seq_ESCs_Human0.88191025
177ZNF274_21170338_ChIP-Seq_K562_Hela0.88164661
178YAP1_20516196_ChIP-Seq_MESCs_Mouse0.86759896
179TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.86508907
180OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84684659
181TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83547935
182SMAD4_21741376_ChIP-Seq_HESCs_Human0.82942521
183TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.82848207
184AR_25329375_ChIP-Seq_VCAP_Human0.82316797
185TOP2B_26459242_ChIP-Seq_MCF-7_Human0.81455108
186VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.81117057
187PCGF2_27294783_Chip-Seq_NPCs_Mouse0.80611847
188CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.79898248
189TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79284273
190NR3C1_21868756_ChIP-Seq_MCF10A_Human0.77880073
191ISL1_27105846_Chip-Seq_CPCs_Mouse0.75417743
192LXR_22292898_ChIP-Seq_THP-1_Human0.74925699
193RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.73666988
194EP300_21415370_ChIP-Seq_HL-1_Mouse0.73436600
195ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.72733439
196ZNF263_19887448_ChIP-Seq_K562_Human0.72580953

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting5.86880963
2MP0000685_abnormal_immune_system5.33513311
3MP0003787_abnormal_imprinting4.98298269
4MP0003879_abnormal_hair_cell4.82935004
5* MP0005645_abnormal_hypothalamus_physiol4.37420937
6MP0005671_abnormal_response_to4.31557640
7MP0006276_abnormal_autonomic_nervous3.82931952
8MP0003123_paternal_imprinting3.79389748
9MP0005387_immune_system_phenotype3.58882366
10MP0001790_abnormal_immune_system3.58882366
11MP0008057_abnormal_DNA_replication3.47229961
12MP0001835_abnormal_antigen_presentation3.38176719
13MP0010094_abnormal_chromosome_stability3.34083205
14MP0001800_abnormal_humoral_immune3.31376719
15MP0001485_abnormal_pinna_reflex2.93458707
16MP0003111_abnormal_nucleus_morphology2.87380377
17MP0005000_abnormal_immune_tolerance2.78085825
18MP0003121_genomic_imprinting2.74849277
19MP0003763_abnormal_thymus_physiology2.74294750
20MP0003878_abnormal_ear_physiology2.69350007
21MP0005377_hearing/vestibular/ear_phenot2.69350007
22MP0010234_abnormal_vibrissa_follicle2.61104717
23MP0002398_abnormal_bone_marrow2.53973771
24MP0002254_reproductive_system_inflammat2.45571834
25MP0003077_abnormal_cell_cycle2.41238974
26MP0003303_peritoneal_inflammation2.40168297
27MP0002166_altered_tumor_susceptibility2.39921254
28MP0003693_abnormal_embryo_hatching2.39750325
29MP0002452_abnormal_antigen_presenting2.39640850
30MP0002723_abnormal_immune_serum2.38855706
31MP0002396_abnormal_hematopoietic_system2.24034725
32MP0005423_abnormal_somatic_nervous2.22927578
33MP0002420_abnormal_adaptive_immunity2.22229937
34MP0001348_abnormal_lacrimal_gland2.16964363
35MP0001819_abnormal_immune_cell2.16081454
36MP0004859_abnormal_synaptic_plasticity2.14374689
37MP0003635_abnormal_synaptic_transmissio2.13103783
38MP0001486_abnormal_startle_reflex2.05792331
39MP0002184_abnormal_innervation2.04377041
40MP0000716_abnormal_immune_system2.04124437
41MP0005623_abnormal_meninges_morphology2.01280906
42MP0002638_abnormal_pupillary_reflex1.93235172
43MP0000689_abnormal_spleen_morphology1.92680746
44MP0004742_abnormal_vestibular_system1.92621881
45* MP0000026_abnormal_inner_ear1.92120209
46MP0005451_abnormal_body_composition1.91945398
47MP0001501_abnormal_sleep_pattern1.91536260
48MP0009333_abnormal_splenocyte_physiolog1.90856373
49MP0002722_abnormal_immune_system1.88444852
50MP0002429_abnormal_blood_cell1.87706915
51MP0000703_abnormal_thymus_morphology1.86184045
52MP0008877_abnormal_DNA_methylation1.84603775
53MP0004957_abnormal_blastocyst_morpholog1.80751381
54MP0005025_abnormal_response_to1.76263228
55MP0002006_tumorigenesis1.75375442
56MP0009745_abnormal_behavioral_response1.73975570
57MP0008058_abnormal_DNA_repair1.71130222
58MP0003436_decreased_susceptibility_to1.70285147
59MP0001188_hyperpigmentation1.69743788
60* MP0009046_muscle_twitch1.68580156
61MP0002572_abnormal_emotion/affect_behav1.68568445
62MP0000350_abnormal_cell_proliferation1.65118101
63MP0001963_abnormal_hearing_physiology1.62624881
64MP0009785_altered_susceptibility_to1.60662294
65MP0004885_abnormal_endolymph1.57671718
66MP0008007_abnormal_cellular_replicative1.52969048
67MP0002019_abnormal_tumor_incidence1.50551674
68MP0002138_abnormal_hepatobiliary_system1.47898515
69MP0002063_abnormal_learning/memory/cond1.47401474
70MP0004272_abnormal_basement_membrane1.46766406
71MP0004808_abnormal_hematopoietic_stem1.46695405
72MP0001346_abnormal_lacrimal_gland1.43511981
73MP0000383_abnormal_hair_follicle1.41905569
74MP0003942_abnormal_urinary_system1.41780931
75MP0002909_abnormal_adrenal_gland1.40563289
76MP0002102_abnormal_ear_morphology1.39511771
77MP0001873_stomach_inflammation1.38413685
78MP0002272_abnormal_nervous_system1.37407309
79MP0010155_abnormal_intestine_physiology1.35671526
80MP0002064_seizures1.34983401
81MP0010678_abnormal_skin_adnexa1.34953163
82MP0002733_abnormal_thermal_nociception1.34710217
83MP0000313_abnormal_cell_death1.34496295
84MP0002419_abnormal_innate_immunity1.31177202
85MP0000490_abnormal_crypts_of1.26249702
86MP0001845_abnormal_inflammatory_respons1.25854234
87MP0009278_abnormal_bone_marrow1.25361320
88MP0005310_abnormal_salivary_gland1.23609668
89MP0001529_abnormal_vocalization1.22292639
90MP0001730_embryonic_growth_arrest1.21384112
91MP0002148_abnormal_hypersensitivity_rea1.20831863
92MP0000579_abnormal_nail_morphology1.19769872
93MP0002796_impaired_skin_barrier1.18949077
94MP0005397_hematopoietic_system_phenotyp1.18427565
95MP0001545_abnormal_hematopoietic_system1.18427565
96MP0003300_gastrointestinal_ulcer1.18411778
97MP0003941_abnormal_skin_development1.18050964
98MP0006035_abnormal_mitochondrial_morpho1.14149675
99MP0004947_skin_inflammation1.13376198
100MP0003786_premature_aging1.11073931
101MP0003880_abnormal_central_pattern1.10896754
102MP0003705_abnormal_hypodermis_morpholog1.10519433
103MP0001502_abnormal_circadian_rhythm1.07753649
104MP0002557_abnormal_social/conspecific_i1.07215939
105MP0005248_abnormal_Harderian_gland1.04590836
106MP0006072_abnormal_retinal_apoptosis1.03250705
107MP0005464_abnormal_platelet_physiology1.00840672
108MP0004270_analgesia0.97517630
109MP0002405_respiratory_system_inflammati0.97193690
110MP0000778_abnormal_nervous_system0.96482670
111* MP0002752_abnormal_somatic_nervous0.96318888
112MP0002163_abnormal_gland_morphology0.93917748
113MP0002090_abnormal_vision0.93787422
114MP0001440_abnormal_grooming_behavior0.92512799
115MP0002009_preneoplasia0.92261713
116* MP0002882_abnormal_neuron_morphology0.91457448
117MP0001968_abnormal_touch/_nociception0.91253964
118MP0005647_abnormal_sex_gland0.90846099
119MP0004134_abnormal_chest_morphology0.90821976
120MP0002067_abnormal_sensory_capabilities0.89202690
121MP0004858_abnormal_nervous_system0.88309022
122MP0008995_early_reproductive_senescence0.87950655
123* MP0002066_abnormal_motor_capabilities/c0.86834468
124MP0003183_abnormal_peptide_metabolism0.86301050
125MP0002751_abnormal_autonomic_nervous0.86287037
126MP0000762_abnormal_tongue_morphology0.84357310
127MP0003329_amyloid_beta_deposits0.83467524
128MP0004142_abnormal_muscle_tone0.83094219
129MP0008932_abnormal_embryonic_tissue0.82799278
130MP0002080_prenatal_lethality0.80060059
131MP0005076_abnormal_cell_differentiation0.79927915
132MP0003221_abnormal_cardiomyocyte_apopto0.78901754
133MP0002877_abnormal_melanocyte_morpholog0.77727869
134MP0001943_abnormal_respiration0.77623807
135MP0008961_abnormal_basal_metabolism0.77044010
136MP0001191_abnormal_skin_condition0.76659593
137MP0000372_irregular_coat_pigmentation0.75303157
138MP0005197_abnormal_uvea_morphology0.75213110
139MP0005386_behavior/neurological_phenoty0.75000331
140MP0004924_abnormal_behavior0.75000331
141MP0000751_myopathy0.74317602
142MP0008469_abnormal_protein_level0.74105139
143MP0005220_abnormal_exocrine_pancreas0.70762911
144MP0000858_altered_metastatic_potential0.69828606
145MP0002098_abnormal_vibrissa_morphology0.69180404
146MP0000049_abnormal_middle_ear0.68768111
147MP0001340_abnormal_eyelid_morphology0.68295603
148MP0004381_abnormal_hair_follicle0.68010125
149MP0001970_abnormal_pain_threshold0.67651992
150MP0001697_abnormal_embryo_size0.67426040
151MP0001853_heart_inflammation0.66301596
152MP0003959_abnormal_lean_body0.65934881
153MP0005501_abnormal_skin_physiology0.65890785
154MP0004085_abnormal_heartbeat0.65795490
155MP0004811_abnormal_neuron_physiology0.65570605
156* MP0000631_abnormal_neuroendocrine_gland0.65498302
157MP0000358_abnormal_cell_content/0.65408343
158MP0010771_integument_phenotype0.65265165
159MP0003938_abnormal_ear_development0.65003985
160MP0001672_abnormal_embryogenesis/_devel0.64610147
161MP0005380_embryogenesis_phenotype0.64610147
162MP0005621_abnormal_cell_physiology0.64470668
163MP0005535_abnormal_body_temperature0.63617830
164MP0000609_abnormal_liver_physiology0.63455224
165* MP0002152_abnormal_brain_morphology0.63445030
166MP0003984_embryonic_growth_retardation0.62402721
167MP0004145_abnormal_muscle_electrophysio0.62347575
168MP0001984_abnormal_olfaction0.62347507
169MP0002060_abnormal_skin_morphology0.61724100
170MP0002734_abnormal_mechanical_nocicepti0.61452028
171MP0002069_abnormal_eating/drinking_beha0.61283867
172MP0001661_extended_life_span0.61257379
173MP0000538_abnormal_urinary_bladder0.60307485
174MP0005384_cellular_phenotype0.59425149
175MP0005499_abnormal_olfactory_system0.58468406
176MP0005394_taste/olfaction_phenotype0.58468406
177MP0010386_abnormal_urinary_bladder0.58459128
178MP0003045_fibrosis0.58449280
179MP0002088_abnormal_embryonic_growth/wei0.58247130
180MP0003936_abnormal_reproductive_system0.58008707
181MP0001270_distended_abdomen0.57765191
182MP0000003_abnormal_adipose_tissue0.56950993
183MP0008874_decreased_physiological_sensi0.56383216
184MP0010307_abnormal_tumor_latency0.56292677
185MP0003091_abnormal_cell_migration0.56160225
186MP0006036_abnormal_mitochondrial_physio0.55905580
187MP0005448_abnormal_energy_balance0.55519104
188MP0003656_abnormal_erythrocyte_physiolo0.54747126
189MP0002083_premature_death0.54596565
190MP0002697_abnormal_eye_size0.54238058
191MP0001881_abnormal_mammary_gland0.54031353

Predicted human phenotypes

RankGene SetZ-score
1Gastrointestinal stroma tumor (HP:0100723)8.53752597
2Menstrual irregularities (HP:0000858)7.92898980
3IgA deficiency (HP:0002720)6.50017299
4Recurrent sinusitis (HP:0011108)6.43455435
5Hypercortisolism (HP:0001578)5.97307253
6Agammaglobulinemia (HP:0004432)5.79154593
7Growth hormone excess (HP:0000845)5.45767592
8IgM deficiency (HP:0002850)5.21801341
9Lymphopenia (HP:0001888)5.09432103
10Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.97786225
11Abnormality of cells of the lymphoid lineage (HP:0012140)4.84252532
12Malnutrition (HP:0004395)4.52352301
13Testicular neoplasm (HP:0010788)4.46146744
14Emphysema (HP:0002097)4.39497116
15Cholecystitis (HP:0001082)4.31514131
16Abnormal gallbladder physiology (HP:0012438)4.31514131
17Recurrent bronchitis (HP:0002837)4.31153298
18Agitation (HP:0000713)4.30759003
19Hyperparathyroidism (HP:0000843)4.23704315
20Severe Myopia (HP:0011003)4.09237066
21Meningitis (HP:0001287)4.08045096
22Enlarged penis (HP:0000040)3.92857590
23Abnormality of calcium-phosphate metabolism (HP:0100530)3.92837940
24Macroorchidism (HP:0000053)3.82547854
25Cellulitis (HP:0100658)3.81236388
26Vasculitis (HP:0002633)3.79541313
27IgG deficiency (HP:0004315)3.74612516
28Hypertensive crisis (HP:0100735)3.69558376
29Sex reversal (HP:0012245)3.68439593
30Abnormal sex determination (HP:0012244)3.68439593
31Congenital stationary night blindness (HP:0007642)3.67072814
32Recurrent viral infections (HP:0004429)3.59225028
33Abnormality of T cell physiology (HP:0011840)3.52218754
34Squamous cell carcinoma (HP:0002860)3.49230512
35Hyperthyroidism (HP:0000836)3.39512623
36Chronic diarrhea (HP:0002028)3.35648259
37Adrenal overactivity (HP:0002717)3.34781434
38Concave nail (HP:0001598)3.34407607
39Congenital sensorineural hearing impairment (HP:0008527)3.30839331
40Recurrent lower respiratory tract infections (HP:0002783)3.29184660
41Hypoventilation (HP:0002791)3.25868016
42Panhypogammaglobulinemia (HP:0003139)3.18612894
43Restrictive lung disease (HP:0002091)3.18372660
44Narrow nasal bridge (HP:0000446)3.17366107
45Abnormality of oral frenula (HP:0000190)3.12537914
46Abnormal delayed hypersensitivity skin test (HP:0002963)3.08228798
47Mediastinal lymphadenopathy (HP:0100721)3.08023453
48Lymphoma (HP:0002665)3.06956624
49Basal cell carcinoma (HP:0002671)2.96843291
50Bifid tongue (HP:0010297)2.89221388
51Recurrent pneumonia (HP:0006532)2.89111272
52Leukopenia (HP:0001882)2.88796393
53Upper limb muscle weakness (HP:0003484)2.87985405
54Urticaria (HP:0001025)2.86008568
55Exotropia (HP:0000577)2.84116482
56Poor suck (HP:0002033)2.83912107
57B lymphocytopenia (HP:0010976)2.82690333
58Fibular aplasia (HP:0002990)2.82057718
59Aplasia involving bones of the extremities (HP:0009825)2.81810199
60Aplasia involving bones of the upper limbs (HP:0009823)2.81810199
61Aplasia of the phalanges of the hand (HP:0009802)2.81810199
62Cranial hyperostosis (HP:0004437)2.80955683
63Abnormality of the gastric mucosa (HP:0004295)2.78563439
64Increased IgE level (HP:0003212)2.76931995
65Short tibia (HP:0005736)2.73931904
66Progressive cerebellar ataxia (HP:0002073)2.67714363
67Hepatitis (HP:0012115)2.67127855
68Verrucae (HP:0200043)2.66042121
69Papilloma (HP:0012740)2.66042121
70Hyperacusis (HP:0010780)2.65684461
71Osteomyelitis (HP:0002754)2.64715122
72Dry hair (HP:0011359)2.62979152
73Action tremor (HP:0002345)2.62286438
74Hypothermia (HP:0002045)2.55184010
75Viral hepatitis (HP:0006562)2.53143869
76Recurrent otitis media (HP:0000403)2.51227934
77Increased IgM level (HP:0003496)2.49763047
78Gastrointestinal inflammation (HP:0004386)2.49616275
79Insomnia (HP:0100785)2.49086318
80Recurrent cutaneous fungal infections (HP:0011370)2.48502018
81Chronic mucocutaneous candidiasis (HP:0002728)2.48502018
82Obstructive lung disease (HP:0006536)2.46202958
83Chronic obstructive pulmonary disease (HP:0006510)2.46202958
84Skin rash (HP:0000988)2.43921509
85Inflammation of the large intestine (HP:0002037)2.43043446
86Prostate neoplasm (HP:0100787)2.42298314
87Morphological abnormality of the middle ear (HP:0008609)2.40449345
88Right ventricular cardiomyopathy (HP:0011663)2.40327032
89Focal seizures (HP:0007359)2.36393095
90Rhinitis (HP:0012384)2.35134441
91Onycholysis (HP:0001806)2.35089383
92Restlessness (HP:0000711)2.33400419
93Ankyloglossia (HP:0010296)2.32194399
94Abnormality of B cell number (HP:0010975)2.30191981
95Abnormality of glycolysis (HP:0004366)2.29723722
96Impaired proprioception (HP:0010831)2.28778730
97Colitis (HP:0002583)2.28745378
98Amblyopia (HP:0000646)2.27802909
99Woolly hair (HP:0002224)2.27137914
100Hyperphosphatemia (HP:0002905)2.22241289
101Recurrent fungal infections (HP:0002841)2.21968155
102Reticulocytosis (HP:0001923)2.21803289
103Psychosis (HP:0000709)2.20213525
104Aplasia/Hypoplasia of the tibia (HP:0005772)2.18813929
105Bronchitis (HP:0012387)2.18089045
106Chronic otitis media (HP:0000389)2.17833690
107Cutaneous finger syndactyly (HP:0010554)2.16575530
108Midline defect of the nose (HP:0004122)2.16059962
109Abnormality of T cells (HP:0002843)2.14581577
110Aplasia/Hypoplasia of the thymus (HP:0010515)2.13129326
111Abnormality of macrophages (HP:0004311)2.11529228
112Long palpebral fissure (HP:0000637)2.11430222
113Lower limb amyotrophy (HP:0007210)2.10728854
114Abnormality of cells of the erythroid lineage (HP:0012130)2.10073297
115Poikiloderma (HP:0001029)2.09836239
116Abnormality of the prostate (HP:0008775)2.09749144
117Lip pit (HP:0100267)2.08599887
118Peripheral hypomyelination (HP:0007182)2.08477039
119Myokymia (HP:0002411)2.08316409
120Anxiety (HP:0000739)2.08138551
121Generalized tonic-clonic seizures (HP:0002069)2.08003200
122Abnormal auditory evoked potentials (HP:0006958)2.07502015
123Abnormality of reticulocytes (HP:0004312)2.06976331
124Polyphagia (HP:0002591)2.06921272
125Overlapping toe (HP:0001845)2.06914606
126Deep palmar crease (HP:0006191)2.06290175
127Craniofacial hyperostosis (HP:0004493)2.03672017
128Sparse scalp hair (HP:0002209)2.03208555
129Microvesicular hepatic steatosis (HP:0001414)2.00029736
130Genetic anticipation (HP:0003743)1.99664441
131Encephalitis (HP:0002383)1.98736044
132Eczematoid dermatitis (HP:0000976)1.97814529
133Arthralgia (HP:0002829)1.97073471
134Sepsis (HP:0100806)1.95190731
135Ridged nail (HP:0001807)1.93728713
136Febrile seizures (HP:0002373)1.93664562
137Fatigue (HP:0012378)1.93615054
138Molar tooth sign on MRI (HP:0002419)1.92726758
139Abnormality of midbrain morphology (HP:0002418)1.92726758
140Progressive hearing impairment (HP:0001730)1.92146642
141Entropion (HP:0000621)1.91729572
142Distal lower limb amyotrophy (HP:0008944)1.90353194
143Xerostomia (HP:0000217)1.90083598
144Absence seizures (HP:0002121)1.89330829
145Atonic seizures (HP:0010819)1.86586649
146Recurrent bacterial skin infections (HP:0005406)1.86520855
147Ankle clonus (HP:0011448)1.86372720
148Progressive muscle weakness (HP:0003323)1.84525208
149Abnormal number of erythroid precursors (HP:0012131)1.82066472
150Osteopenia (HP:0000938)1.81734752
151Conical tooth (HP:0000698)1.81575573
152Seborrheic dermatitis (HP:0001051)1.81319047
153Abnormality of the fingertips (HP:0001211)1.81181040
154Supranuclear gaze palsy (HP:0000605)1.80820189
155Abnormality of male internal genitalia (HP:0000022)1.80613862
156Teleangiectasia of the skin (HP:0100585)1.79684421
157Neutropenia (HP:0001875)1.79536235
158Bradycardia (HP:0001662)1.79525375
159Generalized hypotonia (HP:0001290)1.79215147
160Elfin facies (HP:0004428)1.79040972
161Scrotal hypoplasia (HP:0000046)1.78845710
162Petechiae (HP:0000967)1.78843636
163Hyperpituitarism (HP:0010514)1.77799783
164Limb dystonia (HP:0002451)1.77465060
165Epileptic encephalopathy (HP:0200134)1.76921123
166Abnormality of lateral ventricle (HP:0030047)1.76568802
167Progressive sensorineural hearing impairment (HP:0000408)1.76432493
168Reticulocytopenia (HP:0001896)1.75674975
169Cortical dysplasia (HP:0002539)1.75431260
170Ragged-red muscle fibers (HP:0003200)1.75395978
171Curly hair (HP:0002212)1.74883397
172Overriding aorta (HP:0002623)1.74131940
173Unilateral renal agenesis (HP:0000122)1.72396751
174Pterygium (HP:0001059)1.71861308
175Dysmetric saccades (HP:0000641)1.71431632
176Protrusio acetabuli (HP:0003179)1.70077501
177Somatic mutation (HP:0001428)1.63515404
178Steatorrhea (HP:0002570)1.63495555
179Aqueductal stenosis (HP:0002410)1.62433477
180Fat malabsorption (HP:0002630)1.62292131
181Bifid scrotum (HP:0000048)1.61448081
182Onion bulb formation (HP:0003383)1.60309331
183Cutaneous syndactyly (HP:0012725)1.59595946
184Left ventricular hypertrophy (HP:0001712)1.58992435
185Myelomeningocele (HP:0002475)1.58702726
186Fragile skin (HP:0001030)1.58489560
187Hypoplasia of dental enamel (HP:0006297)1.58157364
188Visual hallucinations (HP:0002367)1.58109938
189Alacrima (HP:0000522)1.57975641
190Focal motor seizures (HP:0011153)1.57504160
191Fragile nails (HP:0001808)1.56517296
192Depression (HP:0000716)1.56332751
193Acute lymphatic leukemia (HP:0006721)1.56207680
194Severe muscular hypotonia (HP:0006829)1.54489527
195Failure to thrive in infancy (HP:0001531)1.52332007
196Labial hypoplasia (HP:0000066)1.50272341
197Striae distensae (HP:0001065)1.49898673

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.48938193
2SMG13.97715323
3NTRK33.78651694
4BMPR1B3.72259223
5PRPF4B3.62578596
6MAP3K93.26584668
7MAP4K13.07946061
8NTRK23.05876075
9SIK22.99073117
10VRK12.87048882
11ALK2.81296942
12CDK122.65931931
13MARK12.56678943
14EPHB22.51562492
15FER2.41403280
16MAP3K102.38895023
17TLK12.33142817
18TGFBR12.28709286
19EPHB12.26770408
20MAP3K142.23068840
21GRK12.21724679
22MAPK152.20621084
23ZAK2.12285453
24NEK92.05214592
25TAOK12.02338934
26BUB11.98288507
27PAK31.93785768
28DAPK21.90993181
29CDC71.84500551
30UHMK11.80400571
31DMPK1.75108468
32IRAK41.73076267
33PAK61.72819013
34EPHA31.69719660
35TRIB31.67176535
36DAPK31.66230028
37RPS6KA51.64937120
38EEF2K1.61476911
39NME21.55851917
40SYK1.51585816
41NME11.49971862
42BMPR21.46489815
43DDR21.45378685
44PASK1.45322461
45TBK11.41890749
46NTRK11.38989366
47EPHA41.32862936
48CSF1R1.32682650
49CASK1.32286858
50AURKA1.30457850
51PNCK1.30340580
52FES1.27301842
53MINK11.26545125
54MAP3K81.24610886
55BTK1.23546558
56CCNB11.23394842
57KIT1.23164668
58TAF11.23113441
59MAP3K131.21723502
60LATS21.17240616
61EIF2AK31.14865385
62MAPK131.14149407
63BCKDK1.13449929
64CSNK1G31.13311583
65IKBKB1.12389660
66IKBKE1.08993310
67NEK11.08050852
68VRK21.06157785
69CDK41.04697470
70ICK1.04558649
71CSNK1G21.03769205
72KSR21.03492459
73CDC42BPA1.03479156
74BLK1.03278428
75GRK51.03060195
76EPHA21.02432900
77RPS6KA21.01658492
78BRAF1.01263466
79CAMK2A1.01095788
80MAP3K20.99456810
81STK40.99337690
82TTK0.97585051
83CHEK20.92002955
84MAP3K40.91291515
85MAP3K120.91193768
86DYRK30.91169140
87STK110.90768165
88LYN0.88765826
89HIPK20.87725469
90GRK70.87162070
91ERN10.86770447
92PRKCQ0.86702873
93SIK30.86441873
94STK100.85557374
95PKN10.85538692
96PIM10.85259710
97IRAK30.85148812
98ARAF0.84583114
99CSNK1G10.83873625
100MAPK110.81840880
101JAK10.81069855
102PIM20.80816106
103ADRBK20.79953911
104PAK20.79075472
105RAF10.76208401
106CDK50.76042842
107MAPKAPK50.74497577
108STK240.70788897
109AURKB0.69623516
110ATR0.68594224
111TAOK20.68244169
112CAMK1G0.65855799
113CAMK2G0.65766280
114CHEK10.64894240
115CDK90.64569275
116AKT20.64270946
117FGFR40.63947537
118TYK20.63778709
119CAMK2B0.63695690
120INSRR0.63225264
121CDK80.62875312
122CDK150.62872757
123ADRBK10.62099607
124CDK70.61668927
125PDK40.60844191
126PDK30.60844191
127PRKCH0.60424766
128WEE10.60248476
129JAK30.59987901
130HCK0.58813388
131CDK180.58415622
132MAPKAPK30.58247472
133PDGFRA0.56573584
134MAPK90.55868836
135CDK11A0.55216647
136CDK140.55100731
137CSNK1E0.54450993
138PLK20.54123979
139PRKCG0.53942179
140BRD40.53652636
141MAP2K10.53190785
142CSNK1A1L0.53001573
143RPS6KB20.52624235
144CAMK2D0.52364930
145JAK20.52020349
146DYRK1B0.50359510
147CHUK0.49809654
148PRKD10.49628659
149WNK10.49210632
150PRKCI0.47802179
151PHKG10.47470426
152PHKG20.47470426
153PRKCB0.46322750
154CDK20.46269461
155CLK10.46103623
156CAMK10.44134560
157MAPK40.43650960
158SRPK10.43604140
159NEK20.42867883
160IRAK10.42143879
161RPS6KA30.41924526
162DYRK20.41328461
163MAPK120.40523761
164PRKACA0.40126295
165BMX0.39383808
166PTK60.39188737
167SGK10.39139780
168ROCK10.38877958
169DYRK1A0.38858838
170MATK0.38830128
171CSNK1A10.38586233
172TRPM70.38407160
173FGR0.36637333
174MAP3K70.36341884
175YES10.36304395
176CSNK1D0.35023515
177MARK30.32382589
178PDK10.32271324
179TEC0.31877383
180CDK190.31782251
181PLK40.30875237
182FGFR30.30735214
183SIK10.30663157
184MAP2K20.29229696

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053225.45992838
2Intestinal immune network for IgA production_Homo sapiens_hsa046724.32083344
3Allograft rejection_Homo sapiens_hsa053303.90491099
4Nicotine addiction_Homo sapiens_hsa050333.75999760
5Asthma_Homo sapiens_hsa053103.58608885
6Autoimmune thyroid disease_Homo sapiens_hsa053203.53343142
7Primary immunodeficiency_Homo sapiens_hsa053403.36366785
8Amphetamine addiction_Homo sapiens_hsa050312.83109805
9Cocaine addiction_Homo sapiens_hsa050302.67709332
10Viral myocarditis_Homo sapiens_hsa054162.57523145
11Serotonergic synapse_Homo sapiens_hsa047262.53967637
12Synaptic vesicle cycle_Homo sapiens_hsa047212.49037536
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.47869325
14B cell receptor signaling pathway_Homo sapiens_hsa046622.43432824
15Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.21457107
16GABAergic synapse_Homo sapiens_hsa047272.18609260
17Morphine addiction_Homo sapiens_hsa050322.11945464
18DNA replication_Homo sapiens_hsa030302.09814981
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.04703141
20Glutamatergic synapse_Homo sapiens_hsa047242.02485714
21Leishmaniasis_Homo sapiens_hsa051402.00942845
22Antigen processing and presentation_Homo sapiens_hsa046121.99091801
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.95205152
24Viral carcinogenesis_Homo sapiens_hsa052031.93426253
25Circadian entrainment_Homo sapiens_hsa047131.89737596
26Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.88522904
27Dopaminergic synapse_Homo sapiens_hsa047281.86706657
28Salivary secretion_Homo sapiens_hsa049701.84424261
29Long-term depression_Homo sapiens_hsa047301.79272201
30Renin secretion_Homo sapiens_hsa049241.78916832
31Vibrio cholerae infection_Homo sapiens_hsa051101.77248155
32Insulin secretion_Homo sapiens_hsa049111.74448968
33Herpes simplex infection_Homo sapiens_hsa051681.68003875
34Epstein-Barr virus infection_Homo sapiens_hsa051691.58855591
35Aldosterone synthesis and secretion_Homo sapiens_hsa049251.56143925
36Olfactory transduction_Homo sapiens_hsa047401.52674377
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.47983384
38Influenza A_Homo sapiens_hsa051641.47697466
39Cardiac muscle contraction_Homo sapiens_hsa042601.45121203
40Cholinergic synapse_Homo sapiens_hsa047251.41631714
41Gastric acid secretion_Homo sapiens_hsa049711.39432845
42GnRH signaling pathway_Homo sapiens_hsa049121.39372596
43Taste transduction_Homo sapiens_hsa047421.38614450
44NF-kappa B signaling pathway_Homo sapiens_hsa040641.37853924
45Phenylalanine metabolism_Homo sapiens_hsa003601.36917832
46Oxidative phosphorylation_Homo sapiens_hsa001901.35194584
47Long-term potentiation_Homo sapiens_hsa047201.34757293
48Collecting duct acid secretion_Homo sapiens_hsa049661.34251291
49Mismatch repair_Homo sapiens_hsa034301.31503036
50Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.30736181
51Spliceosome_Homo sapiens_hsa030401.30475897
52Transcriptional misregulation in cancer_Homo sapiens_hsa052021.29512916
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.26589020
54Base excision repair_Homo sapiens_hsa034101.25545451
55Melanogenesis_Homo sapiens_hsa049161.25328827
56Oxytocin signaling pathway_Homo sapiens_hsa049211.20152915
57Estrogen signaling pathway_Homo sapiens_hsa049151.20055065
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.19701318
59Axon guidance_Homo sapiens_hsa043601.18028816
60Measles_Homo sapiens_hsa051621.17148421
61Tryptophan metabolism_Homo sapiens_hsa003801.15910567
62Staphylococcus aureus infection_Homo sapiens_hsa051501.14565501
63Thyroid hormone synthesis_Homo sapiens_hsa049181.11164308
64Cyanoamino acid metabolism_Homo sapiens_hsa004601.10683552
65Calcium signaling pathway_Homo sapiens_hsa040201.10072881
66Toxoplasmosis_Homo sapiens_hsa051451.09717476
67Gap junction_Homo sapiens_hsa045401.07842681
68Parkinsons disease_Homo sapiens_hsa050121.06134979
69Dilated cardiomyopathy_Homo sapiens_hsa054141.05061609
70Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.03913137
71Phototransduction_Homo sapiens_hsa047441.03227636
72Graft-versus-host disease_Homo sapiens_hsa053321.02721612
73Phospholipase D signaling pathway_Homo sapiens_hsa040721.02175827
74Alzheimers disease_Homo sapiens_hsa050101.02132798
75Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.99459588
76Ribosome_Homo sapiens_hsa030100.98778271
77HTLV-I infection_Homo sapiens_hsa051660.98304796
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96500545
79Histidine metabolism_Homo sapiens_hsa003400.93873739
80Biosynthesis of amino acids_Homo sapiens_hsa012300.93450657
81Hepatitis B_Homo sapiens_hsa051610.93302908
82Ovarian steroidogenesis_Homo sapiens_hsa049130.92656590
83Toll-like receptor signaling pathway_Homo sapiens_hsa046200.92408988
84Choline metabolism in cancer_Homo sapiens_hsa052310.91538677
85Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.90862257
86Acute myeloid leukemia_Homo sapiens_hsa052210.90249206
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.90183705
88Homologous recombination_Homo sapiens_hsa034400.87536660
89Bile secretion_Homo sapiens_hsa049760.87267972
90cAMP signaling pathway_Homo sapiens_hsa040240.86478912
91Cell cycle_Homo sapiens_hsa041100.86478616
92Apoptosis_Homo sapiens_hsa042100.85615642
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.83183035
94Glycerolipid metabolism_Homo sapiens_hsa005610.81294589
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80667604
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80436160
97Nucleotide excision repair_Homo sapiens_hsa034200.79777653
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79212958
99One carbon pool by folate_Homo sapiens_hsa006700.78941286
100RNA transport_Homo sapiens_hsa030130.78044643
101Pentose phosphate pathway_Homo sapiens_hsa000300.77419356
102Glucagon signaling pathway_Homo sapiens_hsa049220.74694998
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74506814
104Hematopoietic cell lineage_Homo sapiens_hsa046400.74202589
105Sulfur relay system_Homo sapiens_hsa041220.74138379
106Tuberculosis_Homo sapiens_hsa051520.74054173
107Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.72369460
108Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.70444919
109Fructose and mannose metabolism_Homo sapiens_hsa000510.70166662
110Huntingtons disease_Homo sapiens_hsa050160.69851127
111mRNA surveillance pathway_Homo sapiens_hsa030150.69160886
112Prion diseases_Homo sapiens_hsa050200.68430118
113MAPK signaling pathway_Homo sapiens_hsa040100.66556451
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.66428703
115Alcoholism_Homo sapiens_hsa050340.66037847
116Bladder cancer_Homo sapiens_hsa052190.66037602
117Chronic myeloid leukemia_Homo sapiens_hsa052200.64768061
118Carbon metabolism_Homo sapiens_hsa012000.64691676
119Non-homologous end-joining_Homo sapiens_hsa034500.64618377
120Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63376268
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62015777
122Type II diabetes mellitus_Homo sapiens_hsa049300.61715834
123p53 signaling pathway_Homo sapiens_hsa041150.60776669
124Amoebiasis_Homo sapiens_hsa051460.59035305
125Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58397454
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.57531417
127Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57389825
128Dorso-ventral axis formation_Homo sapiens_hsa043200.55185851
129Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54975280
130RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.53868078
131Tyrosine metabolism_Homo sapiens_hsa003500.52183030
132Wnt signaling pathway_Homo sapiens_hsa043100.49857839
133Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49179956
134Rap1 signaling pathway_Homo sapiens_hsa040150.48747058
135Shigellosis_Homo sapiens_hsa051310.48686146
136T cell receptor signaling pathway_Homo sapiens_hsa046600.48297239
137ErbB signaling pathway_Homo sapiens_hsa040120.47443860
138Glioma_Homo sapiens_hsa052140.47284772
139Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.47134623
1402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.46008344
141Osteoclast differentiation_Homo sapiens_hsa043800.44103533
142Hedgehog signaling pathway_Homo sapiens_hsa043400.43884777
143Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43371054
144Tight junction_Homo sapiens_hsa045300.42630764
145Pancreatic secretion_Homo sapiens_hsa049720.42227989
146Pancreatic cancer_Homo sapiens_hsa052120.42172925
147Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.41803746
148Hippo signaling pathway_Homo sapiens_hsa043900.41569184
149Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.41294745
150Hepatitis C_Homo sapiens_hsa051600.41291601
151cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41199150
152Fanconi anemia pathway_Homo sapiens_hsa034600.39691304
153Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.39399477
154Arginine and proline metabolism_Homo sapiens_hsa003300.37964325
155Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.37962075
156Pyrimidine metabolism_Homo sapiens_hsa002400.37802911
157Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36538992
158Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36030242
159Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.35545560
160Phagosome_Homo sapiens_hsa041450.35142451
161HIF-1 signaling pathway_Homo sapiens_hsa040660.34367815
162RNA degradation_Homo sapiens_hsa030180.33958086
163Ras signaling pathway_Homo sapiens_hsa040140.33764189
164Type I diabetes mellitus_Homo sapiens_hsa049400.32413347
165Rheumatoid arthritis_Homo sapiens_hsa053230.31763558
166Sphingolipid metabolism_Homo sapiens_hsa006000.31428191
167Notch signaling pathway_Homo sapiens_hsa043300.30249213
168TNF signaling pathway_Homo sapiens_hsa046680.29407663
169Neurotrophin signaling pathway_Homo sapiens_hsa047220.28453826
170Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.27997788
171Prolactin signaling pathway_Homo sapiens_hsa049170.27440569
172Non-small cell lung cancer_Homo sapiens_hsa052230.27436397
173Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.26596931
174Jak-STAT signaling pathway_Homo sapiens_hsa046300.25801215
175Small cell lung cancer_Homo sapiens_hsa052220.23457228
176Colorectal cancer_Homo sapiens_hsa052100.23428497
177VEGF signaling pathway_Homo sapiens_hsa043700.21339080
178Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.20500931
179Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.20313995
180Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.18855282
181Chemokine signaling pathway_Homo sapiens_hsa040620.18643180
182Renal cell carcinoma_Homo sapiens_hsa052110.18369749
183Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.16940353
184Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.16600784
185Cysteine and methionine metabolism_Homo sapiens_hsa002700.16370266
186AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.15896124
187Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.14584228
188Prostate cancer_Homo sapiens_hsa052150.14316147
189Lysine degradation_Homo sapiens_hsa003100.13947841

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