HMGXB4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: High mobility group (HMG) proteins are nonhistone chromosomal proteins. See HMG2 (MIM 163906) for additional information on HMG proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)5.23190447
2protein localization to kinetochore (GO:0034501)4.95920086
3nuclear pore organization (GO:0006999)4.70178849
4metaphase plate congression (GO:0051310)4.61911403
5nuclear pore complex assembly (GO:0051292)4.57640832
6DNA unwinding involved in DNA replication (GO:0006268)4.40904952
7mitotic nuclear envelope disassembly (GO:0007077)4.36003559
8DNA replication-dependent nucleosome assembly (GO:0006335)4.31146438
9DNA replication-dependent nucleosome organization (GO:0034723)4.31146438
10mitotic chromosome condensation (GO:0007076)4.30263907
11regulation of spindle organization (GO:0090224)4.25087822
12kinetochore organization (GO:0051383)4.24541463
13DNA replication checkpoint (GO:0000076)4.22780043
14protein localization to chromosome, centromeric region (GO:0071459)4.22440982
15DNA replication initiation (GO:0006270)4.21184760
16mitotic sister chromatid segregation (GO:0000070)4.18450037
17establishment of chromosome localization (GO:0051303)4.10104888
18attachment of spindle microtubules to kinetochore (GO:0008608)4.06116859
19nuclear envelope disassembly (GO:0051081)4.03194246
20membrane disassembly (GO:0030397)4.03194246
21regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.02077778
22CENP-A containing nucleosome assembly (GO:0034080)4.01620209
23chromatin remodeling at centromere (GO:0031055)4.00274865
24sister chromatid segregation (GO:0000819)3.98034174
25positive regulation of chromosome segregation (GO:0051984)3.97873067
26DNA strand elongation involved in DNA replication (GO:0006271)3.96875874
27kinetochore assembly (GO:0051382)3.90289476
28DNA ligation (GO:0006266)3.86100577
29DNA replication-independent nucleosome assembly (GO:0006336)3.85752877
30DNA replication-independent nucleosome organization (GO:0034724)3.85752877
31DNA strand elongation (GO:0022616)3.84063377
32regulation of mitotic spindle organization (GO:0060236)3.81763449
33replication fork processing (GO:0031297)3.81707417
34centriole replication (GO:0007099)3.80007443
35DNA double-strand break processing (GO:0000729)3.73871077
36nucleobase biosynthetic process (GO:0046112)3.71160073
37pore complex assembly (GO:0046931)3.68349635
38negative regulation of DNA-dependent DNA replication (GO:2000104)3.65265000
39telomere maintenance via semi-conservative replication (GO:0032201)3.63843955
40regulation of gene silencing by RNA (GO:0060966)3.61322619
41regulation of posttranscriptional gene silencing (GO:0060147)3.61322619
42regulation of gene silencing by miRNA (GO:0060964)3.61322619
43regulation of DNA endoreduplication (GO:0032875)3.57899002
44mitotic sister chromatid cohesion (GO:0007064)3.57747091
45establishment of integrated proviral latency (GO:0075713)3.55842571
46mitotic recombination (GO:0006312)3.53924510
47regulation of sister chromatid cohesion (GO:0007063)3.53902733
48spindle checkpoint (GO:0031577)3.53676050
49telomere maintenance via recombination (GO:0000722)3.49448319
50histone exchange (GO:0043486)3.48983157
51regulation of chromosome segregation (GO:0051983)3.48908979
52purine nucleobase biosynthetic process (GO:0009113)3.48712438
53ribosome assembly (GO:0042255)3.47619470
54regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.45830654
55regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.43664761
56regulation of mitotic spindle checkpoint (GO:1903504)3.43664761
57positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.43205464
58positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.43205464
59positive regulation of mitotic sister chromatid separation (GO:1901970)3.43205464
60IMP biosynthetic process (GO:0006188)3.39712260
61non-recombinational repair (GO:0000726)3.37634744
62double-strand break repair via nonhomologous end joining (GO:0006303)3.37634744
63negative regulation of chromosome segregation (GO:0051985)3.35438378
64mitotic spindle checkpoint (GO:0071174)3.34423262
65negative regulation of histone methylation (GO:0031061)3.33983397
66regulation of mitotic metaphase/anaphase transition (GO:0030071)3.33681352
67protein localization to chromosome (GO:0034502)3.33353541
68regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.31460106
69telomere maintenance via telomere lengthening (GO:0010833)3.30969816
70regulation of nuclear cell cycle DNA replication (GO:0033262)3.30897855
71negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.30724662
72negative regulation of sister chromatid segregation (GO:0033046)3.30724662
73negative regulation of mitotic sister chromatid separation (GO:2000816)3.30724662
74negative regulation of mitotic sister chromatid segregation (GO:0033048)3.30724662
75folic acid-containing compound biosynthetic process (GO:0009396)3.30563992
76spindle assembly checkpoint (GO:0071173)3.30153902
77formation of translation preinitiation complex (GO:0001731)3.29455763
78mitotic G2/M transition checkpoint (GO:0044818)3.29193373
79negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.27937070
80chromatin assembly or disassembly (GO:0006333)3.27578083
81pre-miRNA processing (GO:0031054)3.27559888
82regulation of centrosome cycle (GO:0046605)3.27514331
83DNA topological change (GO:0006265)3.26179409
84meiotic chromosome segregation (GO:0045132)3.26018968
85mitotic spindle assembly checkpoint (GO:0007094)3.25948642
86negative regulation of DNA recombination (GO:0045910)3.24920638
87synapsis (GO:0007129)3.23041459
88regulation of histone H3-K9 methylation (GO:0051570)3.22849333
89DNA geometric change (GO:0032392)3.22732520
90DNA duplex unwinding (GO:0032508)3.22696868
91microtubule depolymerization (GO:0007019)3.22609230
92regulation of helicase activity (GO:0051095)3.22558023
93maturation of SSU-rRNA (GO:0030490)3.21421656
94somatic hypermutation of immunoglobulin genes (GO:0016446)3.19935451
95somatic diversification of immune receptors via somatic mutation (GO:0002566)3.19935451
96protein K6-linked ubiquitination (GO:0085020)3.19752914
97regulation of sister chromatid segregation (GO:0033045)3.19507233
98regulation of mitotic sister chromatid separation (GO:0010965)3.19507233
99regulation of mitotic sister chromatid segregation (GO:0033047)3.19507233
100regulation of double-strand break repair via homologous recombination (GO:0010569)3.18779623
101chromosome segregation (GO:0007059)3.18346607
102histone H2A monoubiquitination (GO:0035518)3.13559120
103postreplication repair (GO:0006301)3.13551874
104regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.11822343
105nuclear envelope organization (GO:0006998)3.11689496
106resolution of meiotic recombination intermediates (GO:0000712)3.10250122
107nucleotide-excision repair, DNA gap filling (GO:0006297)3.10025344
108regulation of centriole replication (GO:0046599)3.08980556
109mismatch repair (GO:0006298)3.06449187
110DNA strand renaturation (GO:0000733)3.00924638
111ATP-dependent chromatin remodeling (GO:0043044)2.98935462
112DNA catabolic process, exonucleolytic (GO:0000738)2.98153084
113IMP metabolic process (GO:0046040)2.96439157
114recombinational repair (GO:0000725)2.95841089
115sister chromatid cohesion (GO:0007062)2.93660887
116ribosome biogenesis (GO:0042254)2.93341691
117maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.93318024
118double-strand break repair via homologous recombination (GO:0000724)2.90783133
119rRNA modification (GO:0000154)2.88902386
120histone H2A acetylation (GO:0043968)2.88659238
121ribosomal small subunit assembly (GO:0000028)2.88366575
122DNA conformation change (GO:0071103)2.87711746
123intra-S DNA damage checkpoint (GO:0031573)2.85956222
124paraxial mesoderm development (GO:0048339)2.85366011
125translesion synthesis (GO:0019985)2.82711345
126chromosome condensation (GO:0030261)2.75769910
127exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.75641880
128regulation of centrosome duplication (GO:0010824)2.74317230
129positive regulation of histone H3-K4 methylation (GO:0051571)2.74028392

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.39826640
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.38055166
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.96161469
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.74143500
5MYC_19079543_ChIP-ChIP_MESCs_Mouse3.01717856
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.74943659
7MYC_19030024_ChIP-ChIP_MESCs_Mouse2.74534861
8* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.63857503
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.59412260
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.58059141
11AR_21909140_ChIP-Seq_LNCAP_Human2.54235677
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.40865309
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.38747421
14NELFA_20434984_ChIP-Seq_ESCs_Mouse2.37833506
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.33792469
16MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.32868334
17E2F1_21310950_ChIP-Seq_MCF-7_Human2.32620033
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.27506885
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.25880441
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.20312540
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.13467973
22EWS_26573619_Chip-Seq_HEK293_Human2.09060728
23XRN2_22483619_ChIP-Seq_HELA_Human2.08999796
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.08840764
25NANOG_18555785_ChIP-Seq_MESCs_Mouse2.02937727
26EGR1_19374776_ChIP-ChIP_THP-1_Human2.01923641
27E2F7_22180533_ChIP-Seq_HELA_Human10.0585966
28MYCN_18555785_ChIP-Seq_MESCs_Mouse1.97429789
29* FUS_26573619_Chip-Seq_HEK293_Human1.94711960
30HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.94064754
31ZNF274_21170338_ChIP-Seq_K562_Hela1.92228166
32TP63_19390658_ChIP-ChIP_HaCaT_Human1.91718277
33* VDR_23849224_ChIP-Seq_CD4+_Human1.85621375
34E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.83661660
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.81103361
36SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.80336477
37E2F1_18555785_ChIP-Seq_MESCs_Mouse1.78109372
38* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.73119829
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.72912179
40POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.68803533
41TTF2_22483619_ChIP-Seq_HELA_Human1.65033065
42* FOXP3_21729870_ChIP-Seq_TREG_Human1.64543593
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64211089
44POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.63478094
45HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.59005015
46ELK1_19687146_ChIP-ChIP_HELA_Human1.58539692
47VDR_22108803_ChIP-Seq_LS180_Human1.58334131
48SOX2_18555785_ChIP-Seq_MESCs_Mouse1.55326870
49DCP1A_22483619_ChIP-Seq_HELA_Human1.54499952
50THAP11_20581084_ChIP-Seq_MESCs_Mouse1.53137499
51CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.52498961
52POU5F1_16153702_ChIP-ChIP_HESCs_Human1.51971856
53GABP_19822575_ChIP-Seq_HepG2_Human1.51165201
54NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.50130006
55POU3F2_20337985_ChIP-ChIP_501MEL_Human1.48793780
56TAF15_26573619_Chip-Seq_HEK293_Human1.47465206
57KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.44731202
58KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.44731202
59KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.44731202
60KDM5A_27292631_Chip-Seq_BREAST_Human1.43888673
61* CIITA_25753668_ChIP-Seq_RAJI_Human1.43521841
62RBPJ_22232070_ChIP-Seq_NCS_Mouse1.41541486
63* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.40666975
64TCF3_18692474_ChIP-Seq_MEFs_Mouse1.39980499
65ZFX_18555785_ChIP-Seq_MESCs_Mouse1.34866874
66ZFP57_27257070_Chip-Seq_ESCs_Mouse1.33450089
67NOTCH1_21737748_ChIP-Seq_TLL_Human1.33383921
68ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.31453469
69MYC_22102868_ChIP-Seq_BL_Human1.31051785
70FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.30332510
71P300_19829295_ChIP-Seq_ESCs_Human1.26933098
72IRF1_19129219_ChIP-ChIP_H3396_Human1.26428506
73TCF3_18692474_ChIP-Seq_MESCs_Mouse1.25920011
74NANOG_21062744_ChIP-ChIP_HESCs_Human1.25455194
75GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25364321
76PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22016195
77NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.21507650
78KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.21285192
79HOXB4_20404135_ChIP-ChIP_EML_Mouse1.21231345
80STAT3_1855785_ChIP-Seq_MESCs_Mouse1.21219828
81ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.18994610
82ELF1_17652178_ChIP-ChIP_JURKAT_Human1.18362264
83KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17920575
84SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.16551327
85GBX2_23144817_ChIP-Seq_PC3_Human1.15749233
86SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.15037780
87YY1_21170310_ChIP-Seq_MESCs_Mouse1.14858097
88CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.14657080
89SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.14338042
90NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.12704529
91SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.11980930
92ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.11319034
93E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10739104
94IGF1R_20145208_ChIP-Seq_DFB_Human1.10413243
95CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08356429
96FLI1_27457419_Chip-Seq_LIVER_Mouse1.06659499
97ESR1_15608294_ChIP-ChIP_MCF-7_Human1.05530582
98NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.05056761
99ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.05027740
100* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.03397547
101HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.02712532
102* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.01826108
103ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.01718626
104ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.01541048
105SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.00446927
106TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00009870
107GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.99943712
108KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99572339
109CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.99095296
110TFEB_21752829_ChIP-Seq_HELA_Human0.98059329
111MYC_18940864_ChIP-ChIP_HL60_Human0.97968552
112MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97677765
113DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.97533291
114TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.95904558
115SOX9_26525672_Chip-Seq_HEART_Mouse0.91570905
116PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.90595912
117* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.90522476
118RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.88859982
119NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.87820484
120SRF_21415370_ChIP-Seq_HL-1_Mouse0.87266061
121IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.86508921
122CBP_20019798_ChIP-Seq_JUKART_Human0.86508921
123* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.86325246
124PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.86166875
125SOX2_18692474_ChIP-Seq_MESCs_Mouse0.85526715
126SOX2_18692474_ChIP-Seq_MEFs_Mouse0.84258241
127SOX2_16153702_ChIP-ChIP_HESCs_Human0.84141398
128NANOG_16153702_ChIP-ChIP_HESCs_Human0.83698931
129ERG_20887958_ChIP-Seq_HPC-7_Mouse0.82964648
130* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.81114634
131SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.79703962
132PCGF2_27294783_Chip-Seq_ESCs_Mouse0.77928440
133GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.76343361
134UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.76110015
135FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.73756453
136TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.73746259
137POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.73746259

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.01787169
2MP0010094_abnormal_chromosome_stability4.54086393
3MP0003111_abnormal_nucleus_morphology4.46348327
4MP0004957_abnormal_blastocyst_morpholog4.13338042
5MP0003077_abnormal_cell_cycle3.95457871
6MP0008057_abnormal_DNA_replication3.82563447
7MP0008058_abnormal_DNA_repair2.99775046
8MP0003123_paternal_imprinting2.65375639
9MP0008932_abnormal_embryonic_tissue2.53294388
10MP0008007_abnormal_cellular_replicative2.42391871
11MP0001730_embryonic_growth_arrest2.37814860
12MP0000350_abnormal_cell_proliferation2.29886978
13MP0008877_abnormal_DNA_methylation2.22527370
14MP0003121_genomic_imprinting2.09155201
15MP0009697_abnormal_copulation2.04097935
16MP0005380_embryogenesis_phenotype1.96365188
17MP0001672_abnormal_embryogenesis/_devel1.96365188
18MP0002085_abnormal_embryonic_tissue1.92853100
19MP0010352_gastrointestinal_tract_polyps1.91941051
20MP0003718_maternal_effect1.90905689
21MP0010307_abnormal_tumor_latency1.88927918
22MP0001697_abnormal_embryo_size1.87830916
23MP0002084_abnormal_developmental_patter1.86274468
24MP0002396_abnormal_hematopoietic_system1.84152231
25MP0003890_abnormal_embryonic-extraembry1.80587309
26MP0000569_abnormal_digit_pigmentation1.76139430
27MP0003984_embryonic_growth_retardation1.70921880
28MP0002088_abnormal_embryonic_growth/wei1.68199898
29MP0003567_abnormal_fetal_cardiomyocyte1.64882028
30MP0010030_abnormal_orbit_morphology1.63709444
31MP0002086_abnormal_extraembryonic_tissu1.57017481
32MP0002102_abnormal_ear_morphology1.56968608
33MP0002080_prenatal_lethality1.56667893
34MP0006292_abnormal_olfactory_placode1.56471765
35MP0004197_abnormal_fetal_growth/weight/1.56206150
36MP0003786_premature_aging1.56065586
37MP0003937_abnormal_limbs/digits/tail_de1.54044772
38MP0006072_abnormal_retinal_apoptosis1.51571402
39MP0001293_anophthalmia1.49842152
40MP0003941_abnormal_skin_development1.49798905
41MP0005076_abnormal_cell_differentiation1.48200933
42MP0003122_maternal_imprinting1.47752746
43MP0002234_abnormal_pharynx_morphology1.41527641
44MP0000490_abnormal_crypts_of1.37274341
45MP0003119_abnormal_digestive_system1.33385550
46MP0002653_abnormal_ependyma_morphology1.29906654
47MP0000313_abnormal_cell_death1.28896540
48MP0000372_irregular_coat_pigmentation1.24812384
49MP0001529_abnormal_vocalization1.23239105
50MP0009053_abnormal_anal_canal1.22981078
51MP0000537_abnormal_urethra_morphology1.22555171
52MP0002210_abnormal_sex_determination1.22522282
53MP0004133_heterotaxia1.20444202
54MP0003787_abnormal_imprinting1.18160976
55MP0000631_abnormal_neuroendocrine_gland1.17178667
56MP0005394_taste/olfaction_phenotype1.16894540
57MP0005499_abnormal_olfactory_system1.16894540
58MP0003315_abnormal_perineum_morphology1.15991370
59MP0002751_abnormal_autonomic_nervous1.13843844
60MP0002019_abnormal_tumor_incidence1.13365589
61MP0001145_abnormal_male_reproductive1.07038520
62MP0001286_abnormal_eye_development1.06983848
63MP0002938_white_spotting1.06609506
64MP0004808_abnormal_hematopoietic_stem1.05639190
65MP0004264_abnormal_extraembryonic_tissu1.04848126
66MP0002111_abnormal_tail_morphology1.01562358
67MP0009703_decreased_birth_body1.01297515
68MP0009672_abnormal_birth_weight1.00282452
69MP0000432_abnormal_head_morphology0.99365306
70MP0000653_abnormal_sex_gland0.98468389
71MP0000428_abnormal_craniofacial_morphol0.97943440
72MP0001849_ear_inflammation0.96943114
73MP0000516_abnormal_urinary_system0.96184438
74MP0005367_renal/urinary_system_phenotyp0.96184438
75MP0003935_abnormal_craniofacial_develop0.95659906
76MP0003698_abnormal_male_reproductive0.95022710
77MP0001929_abnormal_gametogenesis0.94682302
78MP0003755_abnormal_palate_morphology0.94380118
79MP0005253_abnormal_eye_physiology0.91031683
80MP0001119_abnormal_female_reproductive0.87823891
81MP0003861_abnormal_nervous_system0.87381580
82MP0000778_abnormal_nervous_system0.86344269
83MP0005084_abnormal_gallbladder_morpholo0.85971761
84MP0000647_abnormal_sebaceous_gland0.84860168
85MP0000427_abnormal_hair_cycle0.83846260
86MP0005187_abnormal_penis_morphology0.83351154
87MP0002009_preneoplasia0.82948978
88MP0002092_abnormal_eye_morphology0.81264826
89MP0002249_abnormal_larynx_morphology0.80432189
90MP0005391_vision/eye_phenotype0.80413021
91MP0005384_cellular_phenotype0.80195970
92MP0005621_abnormal_cell_physiology0.79341077
93MP0000358_abnormal_cell_content/0.78454021
94MP0005174_abnormal_tail_pigmentation0.77778424
95MP0010234_abnormal_vibrissa_follicle0.77408829
96MP0002697_abnormal_eye_size0.77137745
97MP0003385_abnormal_body_wall0.75375095
98MP0005389_reproductive_system_phenotype0.75158007
99MP0002736_abnormal_nociception_after0.74639959
100MP0001915_intracranial_hemorrhage0.74364026
101MP0006035_abnormal_mitochondrial_morpho0.74230264
102MP0002114_abnormal_axial_skeleton0.74146621
103MP0003943_abnormal_hepatobiliary_system0.73850105
104MP0003136_yellow_coat_color0.73739040
105MP0005023_abnormal_wound_healing0.73145671
106MP0002925_abnormal_cardiovascular_devel0.72958182
107MP0008789_abnormal_olfactory_epithelium0.72922280
108MP0002282_abnormal_trachea_morphology0.72212137
109MP0002160_abnormal_reproductive_system0.71729163
110MP0001984_abnormal_olfaction0.71547349
111MP0002161_abnormal_fertility/fecundity0.71479787
112MP0009250_abnormal_appendicular_skeleto0.71109219
113MP0008995_early_reproductive_senescence0.70370128
114MP0005397_hematopoietic_system_phenotyp0.69974997
115MP0001545_abnormal_hematopoietic_system0.69974997
116MP0000733_abnormal_muscle_development0.67500134
117MP0000703_abnormal_thymus_morphology0.66878077
118MP0003699_abnormal_female_reproductive0.66046374
119MP0002116_abnormal_craniofacial_bone0.65509210
120MP0009333_abnormal_splenocyte_physiolog0.65273154
121MP0000566_synostosis0.64855999
122MP0003936_abnormal_reproductive_system0.64180467
123MP0002233_abnormal_nose_morphology0.63783633
124MP0002177_abnormal_outer_ear0.62460006
125MP0003115_abnormal_respiratory_system0.62452734
126MP0003566_abnormal_cell_adhesion0.62008830
127MP0003938_abnormal_ear_development0.61818975
128MP0005395_other_phenotype0.60990686
129MP0000049_abnormal_middle_ear0.60875985
130MP0009278_abnormal_bone_marrow0.59185802
131MP0003942_abnormal_urinary_system0.59027423

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.92405923
2Chromsome breakage (HP:0040012)4.76375182
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.47982368
4Breast hypoplasia (HP:0003187)3.96978795
5Ependymoma (HP:0002888)3.84324567
6Abnormality of the labia minora (HP:0012880)3.78535907
7Patellar aplasia (HP:0006443)3.52050563
8Medulloblastoma (HP:0002885)3.51917021
9Colon cancer (HP:0003003)3.43895446
10Aplasia/Hypoplasia of the patella (HP:0006498)3.28402499
11Abnormality of chromosome stability (HP:0003220)3.25293606
12Reticulocytopenia (HP:0001896)3.12417817
13Meckel diverticulum (HP:0002245)3.08588759
14Supernumerary spleens (HP:0009799)3.04663365
15Absent radius (HP:0003974)2.97952959
16Abnormality of the ileum (HP:0001549)2.95393749
17Aplasia/Hypoplasia of the uvula (HP:0010293)2.92950155
18Abnormality of the preputium (HP:0100587)2.86325601
19Aplasia involving forearm bones (HP:0009822)2.80852543
20Absent forearm bone (HP:0003953)2.80852543
21Impulsivity (HP:0100710)2.72443593
22Rhabdomyosarcoma (HP:0002859)2.71990667
23Abnormality of the astrocytes (HP:0100707)2.71712477
24Astrocytoma (HP:0009592)2.71712477
25Selective tooth agenesis (HP:0001592)2.71145749
26Facial hemangioma (HP:0000329)2.70874527
27Ectopic kidney (HP:0000086)2.70832925
28Agnosia (HP:0010524)2.66957425
29Aplasia/Hypoplasia of the sternum (HP:0006714)2.66456217
30Volvulus (HP:0002580)2.65776013
31Nephroblastoma (Wilms tumor) (HP:0002667)2.57390457
32Molar tooth sign on MRI (HP:0002419)2.57175062
33Abnormality of midbrain morphology (HP:0002418)2.57175062
34Duodenal stenosis (HP:0100867)2.56540273
35Small intestinal stenosis (HP:0012848)2.56540273
36Septo-optic dysplasia (HP:0100842)2.55730969
37Rough bone trabeculation (HP:0100670)2.54976237
38Deviation of the thumb (HP:0009603)2.54581719
39Abnormal lung lobation (HP:0002101)2.53050489
40Myelodysplasia (HP:0002863)2.52493464
41Glioma (HP:0009733)2.50820569
42Proximal placement of thumb (HP:0009623)2.49873744
43Pancreatic fibrosis (HP:0100732)2.46475405
44Hypoplastic pelvis (HP:0008839)2.45962597
45Abnormal number of incisors (HP:0011064)2.41865564
46Shawl scrotum (HP:0000049)2.39791862
47Oral leukoplakia (HP:0002745)2.39315302
48Embryonal renal neoplasm (HP:0011794)2.39090366
49Neoplasm of the oral cavity (HP:0100649)2.38837430
50Carpal bone hypoplasia (HP:0001498)2.38574570
51Aplasia/hypoplasia of the humerus (HP:0006507)2.33889800
52Rib fusion (HP:0000902)2.32531718
53Cortical dysplasia (HP:0002539)2.31455078
54Pancreatic cysts (HP:0001737)2.30576346
55Atresia of the external auditory canal (HP:0000413)2.27764554
56Neoplasm of the pancreas (HP:0002894)2.26911217
57Absent thumb (HP:0009777)2.25576401
58Sloping forehead (HP:0000340)2.24922654
59Duplicated collecting system (HP:0000081)2.22589862
60Short 4th metacarpal (HP:0010044)2.21441452
61Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.21441452
62Increased nuchal translucency (HP:0010880)2.20176834
63Clubbing of toes (HP:0100760)2.20106084
64Abnormality of the duodenum (HP:0002246)2.20046033
65Abnormality of the anterior horn cell (HP:0006802)2.18840366
66Degeneration of anterior horn cells (HP:0002398)2.18840366
67Nephronophthisis (HP:0000090)2.18091899
68Short thumb (HP:0009778)2.17161595
69Abdominal situs inversus (HP:0003363)2.15349911
70Abnormality of abdominal situs (HP:0011620)2.15349911
71Short humerus (HP:0005792)2.12269354
72Oligodactyly (hands) (HP:0001180)2.11974207
73Cafe-au-lait spot (HP:0000957)2.11316301
74Premature graying of hair (HP:0002216)2.11193100
75Tracheoesophageal fistula (HP:0002575)2.10591036
76Bone marrow hypocellularity (HP:0005528)2.10569599
77True hermaphroditism (HP:0010459)2.09464320
78Abnormality of DNA repair (HP:0003254)2.06306965
79Horseshoe kidney (HP:0000085)2.04925181
80Biliary tract neoplasm (HP:0100574)2.03901779
81Hypoplasia of the pons (HP:0012110)2.03377982
82Neoplasm of striated muscle (HP:0009728)2.03019329
83Tubulointerstitial nephritis (HP:0001970)2.01418526
84Abnormal trabecular bone morphology (HP:0100671)2.00506762
85Abnormality of the carotid arteries (HP:0005344)1.99571529
86Breast aplasia (HP:0100783)1.97841295
87Bifid tongue (HP:0010297)1.97833296
88Abnormality of cells of the erythroid lineage (HP:0012130)1.97695715
89Abnormal hair whorl (HP:0010721)1.95740930
90Aplasia/Hypoplasia of the sacrum (HP:0008517)1.95734840
91Missing ribs (HP:0000921)1.95265475
92Triphalangeal thumb (HP:0001199)1.94807888
93Gastrointestinal carcinoma (HP:0002672)1.94612524
94Malignant gastrointestinal tract tumors (HP:0006749)1.94612524
95Intestinal atresia (HP:0011100)1.93809912
96Abnormality of the pons (HP:0007361)1.93458400
9711 pairs of ribs (HP:0000878)1.93416648
98Acute necrotizing encephalopathy (HP:0006965)1.93040173
99Abnormality of the renal collecting system (HP:0004742)1.92906463
100Cerebral hypomyelination (HP:0006808)1.92493936
101Aplasia/Hypoplasia of the breasts (HP:0010311)1.90954298
102Supernumerary bones of the axial skeleton (HP:0009144)1.90435824
103Absent septum pellucidum (HP:0001331)1.90193060
104Median cleft lip (HP:0000161)1.90138875
105Optic nerve hypoplasia (HP:0000609)1.89400613
106Aplasia/Hypoplasia of the tongue (HP:0010295)1.89254241
107Anophthalmia (HP:0000528)1.88320206
108Premature ovarian failure (HP:0008209)1.87483264
109Amaurosis fugax (HP:0100576)1.86544685
110Neoplasm of the colon (HP:0100273)1.86309305
111Anal stenosis (HP:0002025)1.85231066
112Supernumerary ribs (HP:0005815)1.85045168
113Abnormal number of erythroid precursors (HP:0012131)1.84726724
114Slender long bone (HP:0003100)1.84660728
115Microtia (HP:0008551)1.84353279
116Abnormality of the septum pellucidum (HP:0007375)1.83682681
117Abnormality of the fingertips (HP:0001211)1.83441148
118Prominent nose (HP:0000448)1.83118686
119Preaxial hand polydactyly (HP:0001177)1.82893307
120Acute encephalopathy (HP:0006846)1.82759685
121Basal cell carcinoma (HP:0002671)1.81686033
122Oligodactyly (HP:0012165)1.80895816
123Broad thumb (HP:0011304)1.80735758
124Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.80455585
125Abnormality of the renal medulla (HP:0100957)1.80350496
126Cellular immunodeficiency (HP:0005374)1.79934809
127Aplastic anemia (HP:0001915)1.79286266
128Long eyelashes (HP:0000527)1.79001783
129Sandal gap (HP:0001852)1.78437866
130Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.76994162
131Astigmatism (HP:0000483)1.75528504
132Medial flaring of the eyebrow (HP:0010747)1.73025655
133Facial cleft (HP:0002006)1.72197255
134Dandy-Walker malformation (HP:0001305)1.70867176
135Pendular nystagmus (HP:0012043)1.68503888
136Gastrointestinal atresia (HP:0002589)1.67004959
137Methylmalonic acidemia (HP:0002912)1.66780270
138Stenosis of the external auditory canal (HP:0000402)1.66303128
139Small hand (HP:0200055)1.63559902
140Aganglionic megacolon (HP:0002251)1.61987582
141Progressive macrocephaly (HP:0004481)1.61282962
142Arteriovenous malformation (HP:0100026)1.60660506
143Genital tract atresia (HP:0001827)1.58524136
144Choanal atresia (HP:0000453)1.58500813
145Aqueductal stenosis (HP:0002410)1.58329023
146Narrow forehead (HP:0000341)1.58067438
147Urethral obstruction (HP:0000796)1.57864665
148Anencephaly (HP:0002323)1.56059667
149Abnormality of methionine metabolism (HP:0010901)1.55528291
150Holoprosencephaly (HP:0001360)1.55437124
151Hyperglycinemia (HP:0002154)1.54864797
152Increased hepatocellular lipid droplets (HP:0006565)1.54183956

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.76489550
2BUB14.21119735
3WEE14.01792657
4TTK3.29581768
5NEK23.06325859
6SRPK12.85853615
7PLK42.83038764
8CDK122.80025296
9TNIK2.54202972
10PLK12.26229641
11NEK12.26089022
12BRSK22.17083536
13TSSK62.16430463
14PLK32.13674044
15VRK22.02516300
16WNK32.00363329
17RPS6KB21.92346657
18MKNK11.91215435
19CHEK21.90996945
20EPHA21.87894191
21CDK71.86149962
22ATR1.85888863
23AURKB1.83264725
24VRK11.80022802
25LATS11.79299442
26EIF2AK11.77577194
27TRIM281.75192168
28MST41.68349819
29ACVR1B1.62454643
30MKNK21.61048017
31STK161.59304277
32PASK1.59163306
33STK38L1.54775066
34DYRK31.54484131
35CHEK11.54349150
36NME11.52643162
37BMPR1B1.48836745
38MAP3K81.48310980
39TAF11.46003773
40CASK1.44180494
41STK101.36139392
42CDK41.32077601
43TLK11.31715639
44EEF2K1.31392929
45PNCK1.26142383
46BRSK11.23526486
47STK31.23491896
48LATS21.22726643
49ATM1.22173098
50EIF2AK31.20917429
51FRK1.20752367
52STK41.20334189
53ZAK1.20020068
54BRD41.15055712
55AURKA1.14027696
56TESK21.12391000
57CDK21.07820010
58PLK21.07086790
59RPS6KA41.02721584
60MAP3K40.99403811
61MELK0.93022986
62PIM10.89970054
63STK390.88566405
64ERBB30.88159353
65CDK10.88079258
66BRAF0.87031814
67MAP4K20.85869701
68CDK60.85317252
69ALK0.85139785
70CDK80.84816012
71CCNB10.81096729
72TGFBR10.80618369
73BCR0.80576541
74NME20.78814764
75CAMK1G0.76325258
76STK240.75709800
77PAK40.75351801
78AKT30.74745807
79MAPK130.74420867
80PRKCI0.71424389
81CSNK1G20.70686850
82CSNK2A20.66676372
83DYRK20.65080710
84CSNK1E0.63047591
85MTOR0.62944621
86MAP3K60.62328240
87SCYL20.60836849
88PAK10.56403840
89RPS6KA50.56167762
90CSNK2A10.55400437
91NLK0.53458195
92EIF2AK20.52017945
93MAP3K100.51264758
94PRKCG0.49016377
95CSNK1D0.48900027
96PRKDC0.48573103
97CAMK1D0.48272477
98ERBB40.45206460
99MAPK140.44777003
100CDK90.44165134
101GRK10.44130127
102PAK20.42174025
103MINK10.42139357
104RAF10.41550222
105CSNK1G10.40797265
106PBK0.38881751
107CSNK1G30.38526463
108OXSR10.36633022
109GSK3B0.35352177
110YES10.35077020
111DMPK0.33584060
112NUAK10.33420104
113AKT10.31717394
114MARK10.31576379
115CSNK1A1L0.31056486
116AKT20.30654579
117CLK10.29625406
118FGFR20.29615944
119PRKCE0.29473504
120MAPK10.28606389
121MARK30.28129573
122WNK40.27481182
123CSNK1A10.24815680
124FGFR10.23878962
125CDK30.23217876
126PAK30.22983351
127PRKACB0.22220386
128FLT30.19822311
129MET0.19074963
130MAPK100.17672550
131LRRK20.17636405
132RPS6KB10.16595374
133KSR10.16035572
134CHUK0.13807225
135RPS6KA10.12017305

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.50749256
2Mismatch repair_Homo sapiens_hsa034304.34567881
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.78550695
4RNA transport_Homo sapiens_hsa030133.43206745
5Cell cycle_Homo sapiens_hsa041103.32536025
6Spliceosome_Homo sapiens_hsa030403.30070606
7Homologous recombination_Homo sapiens_hsa034403.23041463
8RNA polymerase_Homo sapiens_hsa030203.00158369
9Base excision repair_Homo sapiens_hsa034102.88969928
10Nucleotide excision repair_Homo sapiens_hsa034202.80354640
11Fanconi anemia pathway_Homo sapiens_hsa034602.66101402
12One carbon pool by folate_Homo sapiens_hsa006702.45568158
13Basal transcription factors_Homo sapiens_hsa030222.40254790
14Ribosome_Homo sapiens_hsa030102.39609477
15Non-homologous end-joining_Homo sapiens_hsa034502.36144550
16RNA degradation_Homo sapiens_hsa030182.29753506
17Proteasome_Homo sapiens_hsa030502.12550056
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.11085798
19mRNA surveillance pathway_Homo sapiens_hsa030152.09171855
20Pyrimidine metabolism_Homo sapiens_hsa002402.05969394
21p53 signaling pathway_Homo sapiens_hsa041151.91025645
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.61521733
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.41564664
24Steroid biosynthesis_Homo sapiens_hsa001001.38188739
25Propanoate metabolism_Homo sapiens_hsa006401.35070765
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.33042074
27Oocyte meiosis_Homo sapiens_hsa041141.32216459
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30652946
29Systemic lupus erythematosus_Homo sapiens_hsa053221.26043176
30Epstein-Barr virus infection_Homo sapiens_hsa051691.18102344
31Oxidative phosphorylation_Homo sapiens_hsa001901.17656606
32Purine metabolism_Homo sapiens_hsa002301.16141413
33MicroRNAs in cancer_Homo sapiens_hsa052061.15425436
34Viral carcinogenesis_Homo sapiens_hsa052031.12520377
35Parkinsons disease_Homo sapiens_hsa050121.10386138
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.04435651
37Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.03450568
38Hippo signaling pathway_Homo sapiens_hsa043901.00555442
39Basal cell carcinoma_Homo sapiens_hsa052170.97837317
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.94597401
41Vitamin B6 metabolism_Homo sapiens_hsa007500.93596975
42TGF-beta signaling pathway_Homo sapiens_hsa043500.91074749
43HTLV-I infection_Homo sapiens_hsa051660.90267737
44Herpes simplex infection_Homo sapiens_hsa051680.87609835
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.86071740
46Pyruvate metabolism_Homo sapiens_hsa006200.85416556
47Small cell lung cancer_Homo sapiens_hsa052220.82292565
48Thyroid cancer_Homo sapiens_hsa052160.80941789
49Antigen processing and presentation_Homo sapiens_hsa046120.75493751
50Fatty acid elongation_Homo sapiens_hsa000620.74992133
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.74085141
52Butanoate metabolism_Homo sapiens_hsa006500.73946951
53Hedgehog signaling pathway_Homo sapiens_hsa043400.73873625
54Colorectal cancer_Homo sapiens_hsa052100.73220405
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70852407
56Adherens junction_Homo sapiens_hsa045200.70514391
57Notch signaling pathway_Homo sapiens_hsa043300.67819653
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61080161
59Phototransduction_Homo sapiens_hsa047440.56384385
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55693790
61Pathways in cancer_Homo sapiens_hsa052000.55116896
62Alcoholism_Homo sapiens_hsa050340.54902305
63Selenocompound metabolism_Homo sapiens_hsa004500.54310846
64Prostate cancer_Homo sapiens_hsa052150.53993743
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50425339
66Folate biosynthesis_Homo sapiens_hsa007900.50011111
67Wnt signaling pathway_Homo sapiens_hsa043100.48675261
68Metabolic pathways_Homo sapiens_hsa011000.47461320
69Tight junction_Homo sapiens_hsa045300.47201380
70Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46032052
71Bladder cancer_Homo sapiens_hsa052190.45033510
72Chronic myeloid leukemia_Homo sapiens_hsa052200.44612523
73mTOR signaling pathway_Homo sapiens_hsa041500.44303421
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42653664
75Melanoma_Homo sapiens_hsa052180.42309669
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42273349
77Alzheimers disease_Homo sapiens_hsa050100.41440724
78Cysteine and methionine metabolism_Homo sapiens_hsa002700.39230318
79Biosynthesis of amino acids_Homo sapiens_hsa012300.38815492
80FoxO signaling pathway_Homo sapiens_hsa040680.37153909
81Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36491215
82Pancreatic cancer_Homo sapiens_hsa052120.36351319
83Olfactory transduction_Homo sapiens_hsa047400.36196241
84Circadian rhythm_Homo sapiens_hsa047100.36151745
85Apoptosis_Homo sapiens_hsa042100.35982534
86Lysine degradation_Homo sapiens_hsa003100.35287723
87Endometrial cancer_Homo sapiens_hsa052130.33862908
88beta-Alanine metabolism_Homo sapiens_hsa004100.33636956
89Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.33190521
90Pentose phosphate pathway_Homo sapiens_hsa000300.33160696
91Hepatitis B_Homo sapiens_hsa051610.32607931
92Caffeine metabolism_Homo sapiens_hsa002320.31950174
93Renal cell carcinoma_Homo sapiens_hsa052110.31427143
94Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.31368251
95Nitrogen metabolism_Homo sapiens_hsa009100.31324314
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31298529
97Non-small cell lung cancer_Homo sapiens_hsa052230.29931451
98Protein export_Homo sapiens_hsa030600.29713703
99Nicotine addiction_Homo sapiens_hsa050330.29695020
100Shigellosis_Homo sapiens_hsa051310.29632653
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29504163
102Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.28431616
103HIF-1 signaling pathway_Homo sapiens_hsa040660.27787929
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.27238048
105Viral myocarditis_Homo sapiens_hsa054160.26736790
1062-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.26673370
107Proteoglycans in cancer_Homo sapiens_hsa052050.26636756
108Carbon metabolism_Homo sapiens_hsa012000.26056181
109NOD-like receptor signaling pathway_Homo sapiens_hsa046210.24592315
110Fatty acid metabolism_Homo sapiens_hsa012120.23177960
111Glutathione metabolism_Homo sapiens_hsa004800.22377513
112NF-kappa B signaling pathway_Homo sapiens_hsa040640.22173374
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.22097093
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.22093123
115PI3K-Akt signaling pathway_Homo sapiens_hsa041510.21453206
116Taste transduction_Homo sapiens_hsa047420.20518081
117Vitamin digestion and absorption_Homo sapiens_hsa049770.19399085
118Drug metabolism - other enzymes_Homo sapiens_hsa009830.19260734
119Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.17781707
120Tryptophan metabolism_Homo sapiens_hsa003800.15512552
121Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.15266730
122Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.15186405
123Primary immunodeficiency_Homo sapiens_hsa053400.15070428
124Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.14874243
125Peroxisome_Homo sapiens_hsa041460.14587114
126Influenza A_Homo sapiens_hsa051640.14328003
127Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.14123773
128N-Glycan biosynthesis_Homo sapiens_hsa005100.12180932
129Huntingtons disease_Homo sapiens_hsa050160.12035638
130Regulation of autophagy_Homo sapiens_hsa041400.11693730
131Leukocyte transendothelial migration_Homo sapiens_hsa046700.11141636
132Acute myeloid leukemia_Homo sapiens_hsa052210.10818468
133Measles_Homo sapiens_hsa051620.10765297
134Ether lipid metabolism_Homo sapiens_hsa005650.10728002
135Legionellosis_Homo sapiens_hsa051340.09933050
136Cyanoamino acid metabolism_Homo sapiens_hsa004600.09444952
137Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.09241047
138Focal adhesion_Homo sapiens_hsa045100.07829784
139Renin-angiotensin system_Homo sapiens_hsa046140.07716610
140Primary bile acid biosynthesis_Homo sapiens_hsa001200.07488513
141Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.07376896
142Arginine and proline metabolism_Homo sapiens_hsa003300.07042830

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