HMGXB3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is one of the non-canonical high mobility group (HMG) genes. The encoded protein contains an HMG-box domain found in DNA binding proteins such as transcription factors and chromosomal proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1doxorubicin metabolic process (GO:0044598)7.48703222
2daunorubicin metabolic process (GO:0044597)7.48703222
3polyketide metabolic process (GO:0030638)7.48703222
4protein localization to kinetochore (GO:0034501)6.34387005
5maintenance of protein location in nucleus (GO:0051457)5.96923358
6negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.82732963
7Golgi transport vesicle coating (GO:0048200)5.81625198
8COPI coating of Golgi vesicle (GO:0048205)5.81625198
9nuclear pore complex assembly (GO:0051292)5.68764856
10histone H4-K5 acetylation (GO:0043981)5.56403783
11histone H4-K8 acetylation (GO:0043982)5.56403783
12regulation of mammary gland epithelial cell proliferation (GO:0033599)5.49181751
13regulation of telomere maintenance via telomerase (GO:0032210)5.45237195
14heterochromatin organization (GO:0070828)5.26012339
15negative regulation of cell cycle G2/M phase transition (GO:1902750)5.19818368
16regulation of response to osmotic stress (GO:0047484)5.19234996
17somite rostral/caudal axis specification (GO:0032525)5.16069759
18nuclear pore organization (GO:0006999)5.10062022
19negative regulation of epidermis development (GO:0045683)4.98708673
20histone H4-K12 acetylation (GO:0043983)4.97222166
21mitotic sister chromatid segregation (GO:0000070)4.97041251
22negative regulation of telomerase activity (GO:0051974)4.94348567
23pre-miRNA processing (GO:0031054)4.87193876
24negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.86625945
25regulation of nuclear cell cycle DNA replication (GO:0033262)4.84162834
26aminoglycoside antibiotic metabolic process (GO:0030647)4.79279612
27protein localization to chromosome, centromeric region (GO:0071459)4.79131469
28rRNA transcription (GO:0009303)4.73458544
29DNA replication-dependent nucleosome assembly (GO:0006335)4.72239562
30DNA replication-dependent nucleosome organization (GO:0034723)4.72239562
31muscle organ morphogenesis (GO:0048644)4.62895657
32chromatin assembly (GO:0031497)4.58319955
33notochord development (GO:0030903)4.41545136
34sister chromatid segregation (GO:0000819)4.39057767
35histone H4-K16 acetylation (GO:0043984)4.33808595
36protein localization to endosome (GO:0036010)4.32523231
37pore complex assembly (GO:0046931)4.16558389
38retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.11024034
39regulation of translation in response to stress (GO:0043555)4.07075130
40positive regulation of DNA-dependent DNA replication (GO:2000105)3.98725950
41regulation of MHC class I biosynthetic process (GO:0045343)3.95718600
42mitotic chromosome condensation (GO:0007076)3.87448511
43mRNA stabilization (GO:0048255)3.85571930
44RNA stabilization (GO:0043489)3.85571930
45negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.75277206
46activation of Rac GTPase activity (GO:0032863)3.73174120
47DNA replication checkpoint (GO:0000076)3.69388382
48adherens junction assembly (GO:0034333)3.68959095
49hormone catabolic process (GO:0042447)3.68054710
50positive regulation of protein deacetylation (GO:0090312)3.67507366
51regulation of gene silencing by RNA (GO:0060966)3.66784233
52regulation of posttranscriptional gene silencing (GO:0060147)3.66784233
53regulation of gene silencing by miRNA (GO:0060964)3.66784233
54cell-substrate junction assembly (GO:0007044)3.63923169
55intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.63685064
56cell-substrate adherens junction assembly (GO:0007045)3.60322433
57focal adhesion assembly (GO:0048041)3.60322433
58branching involved in mammary gland duct morphogenesis (GO:0060444)3.60000960
59negative regulation of epidermal cell differentiation (GO:0045605)3.57476732
60positive regulation of histone deacetylation (GO:0031065)3.57217496
61regulation of cilium movement (GO:0003352)3.56993612
62primitive streak formation (GO:0090009)3.56836420
63cytoskeletal anchoring at plasma membrane (GO:0007016)3.56379374
64rRNA methylation (GO:0031167)3.54893808
65DNA duplex unwinding (GO:0032508)3.52443313
66regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.51769585
67maintenance of protein localization in organelle (GO:0072595)3.51553823
68regulation of hippo signaling (GO:0035330)3.51392750
69interferon-gamma production (GO:0032609)3.50525411
70NLS-bearing protein import into nucleus (GO:0006607)3.50375012
71DNA geometric change (GO:0032392)3.49574501
72regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.49077971
73hemidesmosome assembly (GO:0031581)3.45686691
74trophectodermal cell differentiation (GO:0001829)3.40874344
75regulation of apoptotic process involved in morphogenesis (GO:1902337)3.39588435
76cell fate commitment involved in formation of primary germ layer (GO:0060795)3.39300314
77mannose metabolic process (GO:0006013)3.38800228
78intestinal epithelial cell development (GO:0060576)3.37722767
79cytidine deamination (GO:0009972)3.35379132
80cytidine metabolic process (GO:0046087)3.35379132
81cytidine catabolic process (GO:0006216)3.35379132
82regulation of early endosome to late endosome transport (GO:2000641)3.35260556
83maternal placenta development (GO:0001893)3.33381334
84negative regulation of telomere maintenance (GO:0032205)3.33301353
85maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.31489767
86semaphorin-plexin signaling pathway (GO:0071526)3.27879803
87dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.27465840
88skin morphogenesis (GO:0043589)3.27273463
89protein retention in ER lumen (GO:0006621)3.27272374
90regulation of NFAT protein import into nucleus (GO:0051532)3.27091940
91intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)3.27066916
92negative regulation of erythrocyte differentiation (GO:0045647)3.23525948
93intracellular estrogen receptor signaling pathway (GO:0030520)3.20488242
94rRNA modification (GO:0000154)3.18505802
95spliceosomal tri-snRNP complex assembly (GO:0000244)3.18356251
96barbed-end actin filament capping (GO:0051016)3.17759266
97mitotic nuclear envelope disassembly (GO:0007077)3.13613905
98ribosome biogenesis (GO:0042254)3.12403686
99retinoic acid receptor signaling pathway (GO:0048384)3.10974377
100epithelial cell-cell adhesion (GO:0090136)3.10573808
101response to dietary excess (GO:0002021)3.09253525
102DNA unwinding involved in DNA replication (GO:0006268)3.09042116
103activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.08453393
104spindle assembly (GO:0051225)3.08303562
105regulation of telomere maintenance (GO:0032204)3.07637728
106basement membrane organization (GO:0071711)3.06951783
107microtubule severing (GO:0051013)3.06528312
108nucleoside transmembrane transport (GO:1901642)3.05562712
109formation of translation preinitiation complex (GO:0001731)3.03121243
110negative regulation of potassium ion transmembrane transport (GO:1901380)3.01388719
111phenol-containing compound catabolic process (GO:0019336)2.99765067
112regulation of telomerase activity (GO:0051972)2.98524136
113pinocytosis (GO:0006907)2.98494360
114positive regulation of nuclease activity (GO:0032075)2.98033929
115mitochondrion distribution (GO:0048311)2.97905822
116nuclear envelope disassembly (GO:0051081)2.97675147
117membrane disassembly (GO:0030397)2.97675147
118regulation of nucleobase-containing compound transport (GO:0032239)2.96553324
119regulation of RNA export from nucleus (GO:0046831)2.95984871
120regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.95114376
121regulation of translational fidelity (GO:0006450)2.93987222
122bone trabecula formation (GO:0060346)2.92086824
123epithelial cell differentiation involved in prostate gland development (GO:0060742)2.91810641
124apoptotic process involved in morphogenesis (GO:0060561)2.90156011
125stress fiber assembly (GO:0043149)2.88133244
126vesicle coating (GO:0006901)2.87672414
127regulation of histone H3-K27 methylation (GO:0061085)2.86546127
128proline biosynthetic process (GO:0006561)2.86401457
129hypotonic response (GO:0006971)2.82096950
130protein polyglutamylation (GO:0018095)2.81651736
131endoplasmic reticulum unfolded protein response (GO:0030968)2.81447829
132regulation of glucose import in response to insulin stimulus (GO:2001273)2.81252125
133chromosome condensation (GO:0030261)2.79430431
134cellular modified amino acid catabolic process (GO:0042219)2.79235479
135embryonic process involved in female pregnancy (GO:0060136)2.79078801
136cell migration involved in gastrulation (GO:0042074)2.78969836
137planar cell polarity pathway involved in neural tube closure (GO:0090179)2.78521789
138histone H3-K4 methylation (GO:0051568)2.78002438
139DNA conformation change (GO:0071103)2.72518420
140negative regulation of fatty acid transport (GO:2000192)2.72422824
141ER-nucleus signaling pathway (GO:0006984)2.72195782
142response to laminar fluid shear stress (GO:0034616)2.72113618
143cell adhesion mediated by integrin (GO:0033627)2.71961092
144negative regulation of cell size (GO:0045792)2.71716388
145apoptotic cell clearance (GO:0043277)2.66941213
146regulation of nuclease activity (GO:0032069)2.64632233
147regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.64550575
148positive regulation of blood vessel endothelial cell migration (GO:0043536)2.64083724
149vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.61994031
150cellular response to unfolded protein (GO:0034620)2.59475064
151pentose-phosphate shunt (GO:0006098)2.57019197
152peptidyl-proline hydroxylation (GO:0019511)2.56846730
153endothelial cell chemotaxis (GO:0035767)2.55227865
154snRNA metabolic process (GO:0016073)2.52619590
155cellular protein complex localization (GO:0034629)2.51570585
156protein hydroxylation (GO:0018126)2.51421262
157COPII vesicle coating (GO:0048208)2.50743851
158mammary gland epithelial cell proliferation (GO:0033598)2.48638180
159membrane protein ectodomain proteolysis (GO:0006509)2.48463995
160positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.48449543
161positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.47666956
162modulation by symbiont of host cellular process (GO:0044068)2.45091271
163glycosphingolipid catabolic process (GO:0046479)2.44986586
164protein export from nucleus (GO:0006611)2.44111478
165endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.43701531
166insulin-like growth factor receptor signaling pathway (GO:0048009)2.40638014
167substrate-dependent cell migration (GO:0006929)2.40115052
168positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.38782638
169regulation of translational termination (GO:0006449)2.38213103
170cellular response to topologically incorrect protein (GO:0035967)2.36718018
171negative regulation of viral release from host cell (GO:1902187)2.36601270
172regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.36510637
173positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.33952028
174desmosome organization (GO:0002934)2.33528173
175embryo implantation (GO:0007566)2.32275126
176glucocorticoid receptor signaling pathway (GO:0042921)2.31186314
177vascular endothelial growth factor signaling pathway (GO:0038084)2.26697769
178response to endoplasmic reticulum stress (GO:0034976)2.24370338
179hyaluronan catabolic process (GO:0030214)2.24172747
180glucose catabolic process (GO:0006007)2.23764128
181protein maturation by protein folding (GO:0022417)2.23108522
182retrograde transport, endosome to Golgi (GO:0042147)2.21593097
183iron ion import (GO:0097286)2.21554111
184positive regulation of cell cycle checkpoint (GO:1901978)2.19807998
185peptidyl-lysine dimethylation (GO:0018027)2.19467784
186cortical actin cytoskeleton organization (GO:0030866)2.19399389
187endodermal cell differentiation (GO:0035987)2.19284911
1883-UTR-mediated mRNA stabilization (GO:0070935)2.18998177
189cellular response to epidermal growth factor stimulus (GO:0071364)2.18288317
190negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.17015664

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.65509463
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.40457349
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.40457349
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.40457349
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.47826619
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.85146310
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.13390064
8NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.82640761
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.80685698
10SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.74372682
11POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.73808429
12TP63_19390658_ChIP-ChIP_HaCaT_Human2.69086365
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.56695434
14SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.55589486
15ZNF263_19887448_ChIP-Seq_K562_Human2.40583756
16VDR_21846776_ChIP-Seq_THP-1_Human2.39883981
17SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.37962050
18RARG_19884340_ChIP-ChIP_MEFs_Mouse2.36490997
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.31778144
20MYC_22102868_ChIP-Seq_BL_Human2.29906672
21NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.22034277
22TCF3_18692474_ChIP-Seq_MESCs_Mouse2.21185940
23ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.12010365
24TCF3_18692474_ChIP-Seq_MEFs_Mouse2.08355955
25TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.04397076
26CLOCK_20551151_ChIP-Seq_293T_Human1.96955139
27TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.96291027
28NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.95683586
29KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.94790649
30EGR1_19374776_ChIP-ChIP_THP-1_Human1.89329391
31ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.89062314
32FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.88566454
33STAT3_1855785_ChIP-Seq_MESCs_Mouse1.87409919
34HIF1A_21447827_ChIP-Seq_MCF-7_Human1.82374580
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.78566390
36TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.78312110
37KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.73610389
38P300_27058665_Chip-Seq_ZR-75-30cells_Human1.72736506
39KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.72307113
40SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.70524726
41MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.70073479
42MYC_19079543_ChIP-ChIP_MESCs_Mouse1.68180668
43MYC_18555785_ChIP-Seq_MESCs_Mouse1.65013297
44NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.63058007
45ZFP281_18757296_ChIP-ChIP_E14_Mouse1.59424364
46TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.58617677
47NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.58074719
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.56254093
49ZFP281_27345836_Chip-Seq_ESCs_Mouse1.54707549
50* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.54070163
51POU5F1_16518401_ChIP-PET_MESCs_Mouse1.53499348
52CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.50232436
53NANOG_18555785_ChIP-Seq_MESCs_Mouse1.49930731
54TCF7_22412390_ChIP-Seq_EML_Mouse1.49860940
55SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.48947855
56TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.48818773
57EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.48548119
58NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.46083731
59HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.41480268
60TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.40541330
61UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.40432803
62TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38913566
63POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.38676868
64MYC_19030024_ChIP-ChIP_MESCs_Mouse1.38108675
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.37214793
66UBF1/2_26484160_Chip-Seq_HMECs_Human1.36481788
67KDM2B_26808549_Chip-Seq_SUP-B15_Human1.35342618
68MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.34452110
69POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.33275634
70PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.32545615
71PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.31680784
72NANOG_18692474_ChIP-Seq_MESCs_Mouse1.31423098
73TFEB_21752829_ChIP-Seq_HELA_Human1.30803783
74HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.30294601
75ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29934856
76KDM2B_26808549_Chip-Seq_JURKAT_Human1.29655174
77STAT6_21828071_ChIP-Seq_BEAS2B_Human1.27443842
78POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.26393721
79VDR_24763502_ChIP-Seq_THP-1_Human1.26197351
80EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25676389
81BRD4_27068464_Chip-Seq_AML-cells_Mouse1.25478589
82ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.24983754
83CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.24012794
84NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.23113329
85MAF_26560356_Chip-Seq_TH1_Human1.23034482
86NCOR1_26117541_ChIP-Seq_K562_Human1.22895299
87STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.22835004
88KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.22746978
89RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22203735
90EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.20464081
91TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19925597
92SOX2_18692474_ChIP-Seq_MESCs_Mouse1.19896192
93TP53_22127205_ChIP-Seq_IMR90_Human1.19856931
94CTCF_27219007_Chip-Seq_ERYTHROID_Human1.19703140
95ELK3_25401928_ChIP-Seq_HUVEC_Human1.18858586
96NANOG_18692474_ChIP-Seq_MEFs_Mouse1.18294867
97SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.17524687
98SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.17524687
99KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15835143
100CREB1_26743006_Chip-Seq_LNCaP_Human1.14633201
101NANOG_21062744_ChIP-ChIP_HESCs_Human1.13455489
102RUNX1_27514584_Chip-Seq_MCF-7_Human1.13427851
103SOX2_18555785_ChIP-Seq_MESCs_Mouse1.12331831
104OCT4_18692474_ChIP-Seq_MEFs_Mouse1.10624089
105* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.09673029
106* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.09416630
107TET1_21451524_ChIP-Seq_MESCs_Mouse1.09301501
108DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.09114953
109NANOG_16518401_ChIP-PET_MESCs_Mouse1.09103409
110NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.09049450
111RUNX1_22412390_ChIP-Seq_EML_Mouse1.09000234
112E2F1_17053090_ChIP-ChIP_MCF-7_Human1.07982203
113SOX9_24532713_ChIP-Seq_HFSC_Mouse1.06642108
114SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.06585224
115MYC_18358816_ChIP-ChIP_MESCs_Mouse1.05728127
116AR_21909140_ChIP-Seq_LNCAP_Human1.05055986
117RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.03495305
118P68_20966046_ChIP-Seq_HELA_Human1.03153164
119CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.03117874
120CHD1_26751641_Chip-Seq_LNCaP_Human1.02480611
121ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.01756417
122KDM2B_26808549_Chip-Seq_DND41_Human1.01407875
123NOTCH1_21737748_ChIP-Seq_TLL_Human1.01084756
124RACK7_27058665_Chip-Seq_MCF-7_Human1.01001334
125KDM2B_26808549_Chip-Seq_K562_Human1.00220746
126KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.99800482
127YY1_21170310_ChIP-Seq_MESCs_Mouse0.99482140
128SA1_27219007_Chip-Seq_ERYTHROID_Human0.99115570
129TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.98069968
130MAF_26560356_Chip-Seq_TH2_Human0.98002938
131PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.97311170
132WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97162090
133TBX20_22080862_ChIP-Seq_HEART_Mouse0.97005367
134TBX20_22328084_ChIP-Seq_HEART_Mouse0.97005367
135* ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.96236392
136GATA1_22383799_ChIP-Seq_G1ME_Mouse0.96098683
137CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.94695186
138* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94184660
139TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.94034864
140SOX2_18692474_ChIP-Seq_MEFs_Mouse0.93571807
141SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.93477300
142FOXO3_23340844_ChIP-Seq_DLD1_Human0.93333718
143KDM5A_27292631_Chip-Seq_BREAST_Human0.93116222
144UTX_26944678_Chip-Seq_JUKART_Human0.92368633
145NANOG_16153702_ChIP-ChIP_HESCs_Human0.92101718
146MYCN_18555785_ChIP-Seq_MESCs_Mouse0.91340729
147POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.88346600
148SMC4_20622854_ChIP-Seq_HELA_Human0.88094213
149RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.87747516
150IRF1_19129219_ChIP-ChIP_H3396_Human0.87460239
151CREB1_15753290_ChIP-ChIP_HEK293T_Human0.86752869
152ATF3_27146783_Chip-Seq_COLON_Human0.83451278
153TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.82575137
154TBX3_20139965_ChIP-Seq_ESCs_Mouse0.81991138
155DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.81940030
156NELFA_20434984_ChIP-Seq_ESCs_Mouse0.81208340
157KAP1_27257070_Chip-Seq_ESCs_Mouse0.81082192
158TBX3_20139965_ChIP-Seq_MESCs_Mouse0.80470225
159ESR1_15608294_ChIP-ChIP_MCF-7_Human0.80378717
160CIITA_25753668_ChIP-Seq_RAJI_Human0.80256282
161LXR_22292898_ChIP-Seq_THP-1_Human0.79394013
162CDX2_20551321_ChIP-Seq_CACO-2_Human0.78396135

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004264_abnormal_extraembryonic_tissu4.02802837
2MP0002254_reproductive_system_inflammat3.79582163
3MP0003705_abnormal_hypodermis_morpholog3.57024780
4MP0003890_abnormal_embryonic-extraembry3.34859986
5MP0008438_abnormal_cutaneous_collagen3.17557572
6MP0005058_abnormal_lysosome_morphology3.08516637
7MP0004858_abnormal_nervous_system3.08125432
8MP0005451_abnormal_body_composition3.04031513
9MP0008057_abnormal_DNA_replication3.00640332
10MP0004957_abnormal_blastocyst_morpholog2.94284178
11MP0010352_gastrointestinal_tract_polyps2.92382927
12MP0003011_delayed_dark_adaptation2.89720060
13MP0006292_abnormal_olfactory_placode2.72157582
14MP0003122_maternal_imprinting2.54307561
15MP0005257_abnormal_intraocular_pressure2.52668848
16MP0005499_abnormal_olfactory_system2.47767649
17MP0005394_taste/olfaction_phenotype2.47767649
18MP0003121_genomic_imprinting2.47586414
19MP0010234_abnormal_vibrissa_follicle2.39788535
20MP0009840_abnormal_foam_cell2.25024083
21MP0005075_abnormal_melanosome_morpholog2.23454568
22MP0005380_embryogenesis_phenotype2.22980135
23MP0001672_abnormal_embryogenesis/_devel2.22980135
24MP0004233_abnormal_muscle_weight2.18991811
25MP0002653_abnormal_ependyma_morphology2.16270502
26MP0003984_embryonic_growth_retardation2.12457896
27MP0002088_abnormal_embryonic_growth/wei2.11977930
28MP0003123_paternal_imprinting2.10275736
29MP0002332_abnormal_exercise_endurance2.07902380
30MP0003077_abnormal_cell_cycle1.95751505
31MP0008260_abnormal_autophagy1.95063380
32MP0001849_ear_inflammation1.92843079
33MP0003111_abnormal_nucleus_morphology1.91231638
34MP0004272_abnormal_basement_membrane1.90266023
35MP0000350_abnormal_cell_proliferation1.88569771
36MP0003453_abnormal_keratinocyte_physiol1.88563648
37MP0008961_abnormal_basal_metabolism1.86833058
38MP0005409_darkened_coat_color1.82238817
39MP0006035_abnormal_mitochondrial_morpho1.78710099
40MP0002086_abnormal_extraembryonic_tissu1.72789781
41MP0010030_abnormal_orbit_morphology1.71053418
42MP0001730_embryonic_growth_arrest1.68829715
43MP0002396_abnormal_hematopoietic_system1.64479397
44MP0002084_abnormal_developmental_patter1.63815750
45MP0000537_abnormal_urethra_morphology1.63212659
46MP0002085_abnormal_embryonic_tissue1.60841846
47MP0010094_abnormal_chromosome_stability1.59379117
48MP0001293_anophthalmia1.52016822
49MP0004197_abnormal_fetal_growth/weight/1.49984494
50MP0002060_abnormal_skin_morphology1.49915665
51MP0003300_gastrointestinal_ulcer1.48327188
52MP0003191_abnormal_cellular_cholesterol1.45402149
53MP0000428_abnormal_craniofacial_morphol1.44997324
54MP0002092_abnormal_eye_morphology1.42167921
55MP0002127_abnormal_cardiovascular_syste1.39842924
56MP0000003_abnormal_adipose_tissue1.39141204
57MP0003279_aneurysm1.37879802
58MP0001915_intracranial_hemorrhage1.37354777
59MP0004808_abnormal_hematopoietic_stem1.36980137
60MP0000678_abnormal_parathyroid_gland1.36338079
61MP0001697_abnormal_embryo_size1.35439692
62MP0000858_altered_metastatic_potential1.34947197
63MP0004947_skin_inflammation1.31464466
64MP0003283_abnormal_digestive_organ1.31167586
65MP0003119_abnormal_digestive_system1.25782914
66MP0003787_abnormal_imprinting1.23961464
67MP0002932_abnormal_joint_morphology1.22483483
68MP0002080_prenatal_lethality1.21400739
69MP0003938_abnormal_ear_development1.21026886
70MP0000751_myopathy1.16065318
71MP0002896_abnormal_bone_mineralization1.15013005
72MP0002796_impaired_skin_barrier1.14882097
73MP0001348_abnormal_lacrimal_gland1.14862017
74MP0003693_abnormal_embryo_hatching1.14038179
75MP0008770_decreased_survivor_rate1.12267195
76MP0000767_abnormal_smooth_muscle1.11771302
77MP0005623_abnormal_meninges_morphology1.11696995
78MP0005501_abnormal_skin_physiology1.11037375
79MP0005375_adipose_tissue_phenotype1.10987267
80MP0003935_abnormal_craniofacial_develop1.10169488
81MP0002925_abnormal_cardiovascular_devel1.08817636
82MP0003566_abnormal_cell_adhesion1.08375658
83MP0005666_abnormal_adipose_tissue1.08281604
84MP0000432_abnormal_head_morphology1.07933676
85MP0001216_abnormal_epidermal_layer1.07521768
86MP0010368_abnormal_lymphatic_system1.07468707
87MP0009278_abnormal_bone_marrow1.06908781
88MP0005023_abnormal_wound_healing1.06532244
89MP0001958_emphysema1.06221930
90MP0000313_abnormal_cell_death1.05921062
91MP0002877_abnormal_melanocyte_morpholog1.05682436
92MP0002269_muscular_atrophy1.04726074
93MP0003303_peritoneal_inflammation1.04639274
94MP0003950_abnormal_plasma_membrane1.04032589
95MP0002114_abnormal_axial_skeleton1.02858305
96MP0002998_abnormal_bone_remodeling1.01817239
97MP0003436_decreased_susceptibility_to1.01760308
98MP0008007_abnormal_cellular_replicative1.00714628
99MP0003183_abnormal_peptide_metabolism0.99595446
100MP0005266_abnormal_metabolism0.99266065
101MP0004133_heterotaxia0.98805603
102MP0002233_abnormal_nose_morphology0.98785210
103MP0002089_abnormal_postnatal_growth/wei0.97735475
104MP0003329_amyloid_beta_deposits0.97284282
105MP0000762_abnormal_tongue_morphology0.95142562
106MP0000490_abnormal_crypts_of0.94101099
107MP0004510_myositis0.93719642
108MP0000747_muscle_weakness0.93628379
109MP0006082_CNS_inflammation0.93624046
110MP0000759_abnormal_skeletal_muscle0.92671381
111MP0009703_decreased_birth_body0.92414305
112MP0005076_abnormal_cell_differentiation0.91206771
113MP0000750_abnormal_muscle_regeneration0.90567945
114MP0005275_abnormal_skin_tensile0.89510449
115MP0000371_diluted_coat_color0.89350131
116MP0003755_abnormal_palate_morphology0.88475186
117MP0008932_abnormal_embryonic_tissue0.88294424
118MP0003656_abnormal_erythrocyte_physiolo0.86548264
119MP0002970_abnormal_white_adipose0.85822084
120MP0002277_abnormal_respiratory_mucosa0.83504456
121MP0000358_abnormal_cell_content/0.82623995
122MP0005384_cellular_phenotype0.82501162
123MP0005248_abnormal_Harderian_gland0.80230545
124MP0001853_heart_inflammation0.78539543
125MP0010307_abnormal_tumor_latency0.76490141
126MP0005508_abnormal_skeleton_morphology0.76230747
127MP0001661_extended_life_span0.73677462
128MP0004087_abnormal_muscle_fiber0.73345552
129MP0001243_abnormal_dermal_layer0.73315690
130MP0003634_abnormal_glial_cell0.72661991
131MP0002098_abnormal_vibrissa_morphology0.72430585
132MP0003091_abnormal_cell_migration0.71927019
133MP0004185_abnormal_adipocyte_glucose0.71109429
134MP0009931_abnormal_skin_appearance0.71028447
135MP0002075_abnormal_coat/hair_pigmentati0.69963704
136MP0005621_abnormal_cell_physiology0.69862080
137MP0002111_abnormal_tail_morphology0.69752587
138MP0002019_abnormal_tumor_incidence0.69679122
139MP0008789_abnormal_olfactory_epithelium0.68491013
140MP0003861_abnormal_nervous_system0.68312845
141MP0000377_abnormal_hair_follicle0.68132160
142MP0002116_abnormal_craniofacial_bone0.67800956
143MP0000049_abnormal_middle_ear0.67513602
144MP0005391_vision/eye_phenotype0.67178773
145MP0000266_abnormal_heart_morphology0.67112172
146MP0000467_abnormal_esophagus_morphology0.66947397
147MP0005197_abnormal_uvea_morphology0.66780961
148MP0000733_abnormal_muscle_development0.66406136
149MP0003937_abnormal_limbs/digits/tail_de0.66310395
150MP0002113_abnormal_skeleton_development0.66217439
151MP0003115_abnormal_respiratory_system0.65995133
152MP0005171_absent_coat_pigmentation0.65782807
153MP0000604_amyloidosis0.64980157
154MP0002249_abnormal_larynx_morphology0.64871344
155MP0010630_abnormal_cardiac_muscle0.64009670
156MP0002081_perinatal_lethality0.62102462
157MP0000749_muscle_degeneration0.59925043
158MP0003172_abnormal_lysosome_physiology0.56977872
159MP0003448_altered_tumor_morphology0.55449570

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)6.28260126
2Hypochromic microcytic anemia (HP:0004840)5.26544897
3Abnormality of the lower motor neuron (HP:0002366)5.11501781
4Hepatoblastoma (HP:0002884)5.05407948
5Ependymoma (HP:0002888)4.73647007
6Multiple enchondromatosis (HP:0005701)4.52471876
7Rib fusion (HP:0000902)4.13613014
8Premature rupture of membranes (HP:0001788)3.73320932
9Hyperacusis (HP:0010780)3.66567185
10Abnormality of the astrocytes (HP:0100707)3.65156285
11Astrocytoma (HP:0009592)3.65156285
12Neoplasm of striated muscle (HP:0009728)3.62053717
13Protrusio acetabuli (HP:0003179)3.45477255
14Rhabdomyosarcoma (HP:0002859)3.38816993
15Vertebral compression fractures (HP:0002953)3.31497870
16Broad face (HP:0000283)3.23391119
17Nephroblastoma (Wilms tumor) (HP:0002667)3.13772881
18Flat acetabular roof (HP:0003180)3.13217050
19Chromosomal breakage induced by crosslinking agents (HP:0003221)3.12167016
20Amyotrophic lateral sclerosis (HP:0007354)2.98546512
21Short nail (HP:0001799)2.94471737
22Embryonal renal neoplasm (HP:0011794)2.91801097
23Fused cervical vertebrae (HP:0002949)2.90815791
24Short humerus (HP:0005792)2.86208101
25Abnormality of the salivary glands (HP:0010286)2.84569749
26Hand muscle atrophy (HP:0009130)2.81222397
27Increased connective tissue (HP:0009025)2.76725243
28Aplasia/hypoplasia of the humerus (HP:0006507)2.74272001
29Cerebral aneurysm (HP:0004944)2.73689519
30Chromsome breakage (HP:0040012)2.72079250
31Distal lower limb amyotrophy (HP:0008944)2.71363119
32Abnormality of the distal phalanges of the toes (HP:0010182)2.70121635
33Renal duplication (HP:0000075)2.67263925
34Testicular atrophy (HP:0000029)2.66540095
35Glioma (HP:0009733)2.64907205
36Abnormal cartilage morphology (HP:0002763)2.62604683
37Cervical subluxation (HP:0003308)2.61132087
38Difficulty running (HP:0009046)2.57644613
39Trismus (HP:0000211)2.55124444
40Large earlobe (HP:0009748)2.53407236
41Preauricular skin tag (HP:0000384)2.52146343
42Distal upper limb amyotrophy (HP:0007149)2.50852518
43Upper limb amyotrophy (HP:0009129)2.50852518
44Horizontal nystagmus (HP:0000666)2.50178424
45Ragged-red muscle fibers (HP:0003200)2.48930602
46Hypoplasia of the fovea (HP:0007750)2.48604898
47Aplasia/Hypoplasia of the fovea (HP:0008060)2.48604898
48Hypopigmentation of the fundus (HP:0007894)2.47648461
49Rectal fistula (HP:0100590)2.46716618
50Rectovaginal fistula (HP:0000143)2.46716618
51Intestinal fistula (HP:0100819)2.43258657
52Skin tags (HP:0010609)2.38153252
53Bifid tongue (HP:0010297)2.36979177
54Shawl scrotum (HP:0000049)2.36555934
55Generalized hypotonia (HP:0001290)2.34229479
56Osteolytic defects of the hand bones (HP:0009699)2.32982516
57Osteolytic defects of the phalanges of the hand (HP:0009771)2.32982516
58Abnormality of the distal phalanx of the thumb (HP:0009617)2.32826178
59Natal tooth (HP:0000695)2.32603173
60Insomnia (HP:0100785)2.32436104
61Hyperinsulinemic hypoglycemia (HP:0000825)2.31979612
62Achilles tendon contracture (HP:0001771)2.27720915
63Neoplasm of the heart (HP:0100544)2.27225629
64Atrophic scars (HP:0001075)2.26705544
65Resting tremor (HP:0002322)2.26059412
66Abnormality of chromosome segregation (HP:0002916)2.25552727
67Impulsivity (HP:0100710)2.25180935
68Abnormal lung lobation (HP:0002101)2.24891489
69Pseudobulbar signs (HP:0002200)2.23836830
70Abnormality of the musculature of the hand (HP:0001421)2.23716430
71Thin bony cortex (HP:0002753)2.23159762
72Abnormality of glycolipid metabolism (HP:0010969)2.19084956
73Abnormality of liposaccharide metabolism (HP:0010968)2.19084956
74Abnormality of glycosphingolipid metabolism (HP:0004343)2.19084956
75Short 5th finger (HP:0009237)2.18370770
76Disproportionate tall stature (HP:0001519)2.16141520
77Spinal rigidity (HP:0003306)2.13885847
78Shallow orbits (HP:0000586)2.13717980
79Upper motor neuron abnormality (HP:0002127)2.12731574
80Vaginal fistula (HP:0004320)2.12234772
81Progressive muscle weakness (HP:0003323)2.10868056
82Tetraplegia (HP:0002445)2.10434333
83Malignant neoplasm of the central nervous system (HP:0100836)2.08977132
84Distal lower limb muscle weakness (HP:0009053)2.07630153
85Long palpebral fissure (HP:0000637)2.07307990
86Missing ribs (HP:0000921)2.06924263
87Fragile skin (HP:0001030)2.06213137
88Ulnar bowing (HP:0003031)2.05763307
89Ankyloglossia (HP:0010296)2.05074874
90Glossoptosis (HP:0000162)2.04519303
91Periauricular skin pits (HP:0100277)2.04456913
92Preauricular pit (HP:0004467)2.04456913
93Abnormality of oral frenula (HP:0000190)2.04291599
94Centrally nucleated skeletal muscle fibers (HP:0003687)2.02897648
95Abnormality of the pubic bones (HP:0003172)2.02770766
96Interstitial pulmonary disease (HP:0006530)2.02694641
97Cerebral inclusion bodies (HP:0100314)2.02682554
98Sparse lateral eyebrow (HP:0005338)2.02594572
99Elbow flexion contracture (HP:0002987)2.02585498
100Hypochromic anemia (HP:0001931)2.01605802
101Wormian bones (HP:0002645)2.01432573
102Abnormality of the Achilles tendon (HP:0005109)2.00996448
103Advanced eruption of teeth (HP:0006288)2.00860761
104Abnormality of the thoracic spine (HP:0100711)2.00720065
105Abnormal ossification of hand bones (HP:0005921)2.00514526
106J-shaped sella turcica (HP:0002680)1.99232390
107Partial duplication of thumb phalanx (HP:0009944)1.98533699
108Meckel diverticulum (HP:0002245)1.98171212
109Spinal muscular atrophy (HP:0007269)1.98057279
110Blue sclerae (HP:0000592)1.97107837
111Anomalous pulmonary venous return (HP:0010772)1.97069113
112Abnormality of carpal bone ossification (HP:0006257)1.96828293
113Dysostosis multiplex (HP:0000943)1.96826268
114Aplasia/Hypoplasia of the sternum (HP:0006714)1.96760584
115Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.95882614
116Atrophy/Degeneration involving motor neurons (HP:0007373)1.95732328
117Medulloblastoma (HP:0002885)1.95577399
118Sensory axonal neuropathy (HP:0003390)1.95270782
119Abnormality of the phalanges of the hallux (HP:0010057)1.95086272
120Spinal cord lesions (HP:0100561)1.94297609
121Syringomyelia (HP:0003396)1.94297609
122Obstructive sleep apnea (HP:0002870)1.94295983
123Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.93438771
124Ankle contracture (HP:0006466)1.93327831
125Vertebral fusion (HP:0002948)1.93027838
126Arterial tortuosity (HP:0005116)1.92553641
127Dysmetric saccades (HP:0000641)1.90887615
128Mitral regurgitation (HP:0001653)1.90393845
129Bladder diverticulum (HP:0000015)1.89934505
130Aplasia/Hypoplasia of the macula (HP:0008059)1.89667192
131Angiofibromas (HP:0010615)1.89514298
132Adenoma sebaceum (HP:0009720)1.89514298
133Aneurysm (HP:0002617)1.88808852
134Tongue fasciculations (HP:0001308)1.88608827
135Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.88447832
136Prominent occiput (HP:0000269)1.87660132
137Aplasia/Hypoplasia of the uvula (HP:0010293)1.87477145
138Muscle fibrillation (HP:0010546)1.85631293
139Broad palm (HP:0001169)1.85210305
140Absent frontal sinuses (HP:0002688)1.85059846
141Spondylolisthesis (HP:0003302)1.84700060
142Abnormality of the ileum (HP:0001549)1.83544101
143Asymmetry of the thorax (HP:0001555)1.83488175
144Abnormality of the acetabulum (HP:0003170)1.83186846
145Partial duplication of the phalanx of hand (HP:0009999)1.83054291
146Abnormality of the fovea (HP:0000493)1.82564254
147Dilatation of the ascending aorta (HP:0005111)1.82030593
148Supernumerary spleens (HP:0009799)1.81888003
149Loss of speech (HP:0002371)1.81802714
150Entropion (HP:0000621)1.80946882
151Myocardial infarction (HP:0001658)1.78937268
152Lower limb amyotrophy (HP:0007210)1.78928784
153Broad thumb (HP:0011304)1.78924539
154Aplasia/Hypoplasia affecting the retina (HP:0008061)1.78909031
155Supernumerary nipples (HP:0002558)1.78479064
156Pendular nystagmus (HP:0012043)1.78340446
157Vascular tortuosity (HP:0004948)1.78233126
158Mildly elevated creatine phosphokinase (HP:0008180)1.78232432
159Abnormality of small intestinal villus morphology (HP:0011472)1.77408435
160Patellar dislocation (HP:0002999)1.74975947
161Long toe (HP:0010511)1.74843580
162Biconcave vertebral bodies (HP:0004586)1.74659754
163Persistence of primary teeth (HP:0006335)1.74616653
164Selective tooth agenesis (HP:0001592)1.73852735
165Spinal cord compression (HP:0002176)1.73460988
166Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.73182069
167Vertebral arch anomaly (HP:0008438)1.72858186
168Dislocated radial head (HP:0003083)1.72852107
169Neurofibrillary tangles (HP:0002185)1.72001675
170Abnormality of dentin (HP:0010299)1.71700206
171Difficulty climbing stairs (HP:0003551)1.70349102
172Genu recurvatum (HP:0002816)1.69599697
173Thoracic kyphosis (HP:0002942)1.69081451
174Nuclear cataract (HP:0100018)1.68909059
175Atelectasis (HP:0100750)1.64854935
176Joint laxity (HP:0001388)1.63906821
177Mitral valve prolapse (HP:0001634)1.62313584
178Flattened epiphyses (HP:0003071)1.61810983
179Neuronal loss in central nervous system (HP:0002529)1.60876056
180Coxa vara (HP:0002812)1.60795125
181Deviation of the thumb (HP:0009603)1.59960734
182Increased variability in muscle fiber diameter (HP:0003557)1.59769512
183Abnormality of the fingertips (HP:0001211)1.57657495
184Long eyelashes (HP:0000527)1.57610614
185Aortic dissection (HP:0002647)1.57425570
186Deformed sella turcica (HP:0002681)1.56790935
187Mucopolysacchariduria (HP:0008155)1.56339020
188Urinary glycosaminoglycan excretion (HP:0003541)1.56339020

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK128.63575904
2ERN14.32962078
3GRK53.92045499
4GRK63.61133340
5IRAK33.30426499
6SMG13.17930498
7TYRO32.86324320
8PRPF4B2.68371136
9TTK2.58283261
10CSF1R2.52372176
11STK102.33304127
12NME22.22123469
13TGFBR22.20684660
14MST1R2.16996327
15GRK11.94412055
16MAPK71.94260486
17MAP3K101.87430261
18ADRBK21.83549740
19WNK11.75745016
20MOS1.73503549
21CAMK1D1.70994974
22MATK1.63856976
23EPHA21.57019168
24NTRK11.44027893
25CDK71.39412073
26PAK41.38740968
27FGFR41.37673272
28MET1.35391925
29TRIB31.32278575
30MARK21.31641148
31GRK71.30826090
32PRKD21.30245936
33LATS21.26256144
34ALK1.26217565
35MAP2K31.25095404
36CAMK1G1.24931124
37CDC71.22622992
38CHEK21.21116855
39NEK21.19077626
40CAMK41.16995347
41MAP3K131.15921147
42CDC42BPA1.13838857
43TESK11.13017803
44PRKG21.11705323
45MAP3K141.09092728
46PKN21.08481903
47TAOK21.05976345
48CHEK11.04539060
49MTOR1.04337283
50HIPK21.02918989
51PLK11.01761115
52LMTK21.00900347
53ICK0.97938025
54EPHB10.95470712
55NEK90.92937686
56FGFR30.92228153
57PDGFRA0.91873543
58EEF2K0.90616519
59MAP3K90.85375422
60PIM20.84754624
61PTK60.82501865
62ARAF0.81406539
63RIPK10.80552368
64MAP2K40.79644639
65CDK60.79478158
66RPS6KA20.79384549
67MAP3K70.79110631
68LATS10.77076676
69AKT20.75963010
70RPS6KB20.75794738
71MAPK110.74847769
72MAP3K60.74778575
73TBK10.73902895
74ERBB40.73890307
75CDK40.71559425
76TAOK10.71028254
77PTK20.70675906
78PAK60.66332304
79NEK10.65231614
80PDPK10.63837723
81CSK0.63788909
82BMX0.63591923
83CDK20.63015740
84DDR20.62020952
85ADRBK10.60389993
86TTN0.59170562
87TRPM70.58262358
88SCYL20.58084970
89CLK10.57306777
90RET0.54929069
91MAP3K10.54219752
92BRAF0.52951367
93ZAP700.51628732
94LRRK20.49139924
95RPS6KL10.48262328
96RPS6KC10.48262328
97ITK0.48219079
98PRKD30.48126512
99CDK90.48110777
100MAP3K20.47923305
101MELK0.47574669
102MAP3K80.47137631
103ATM0.46690096
104PRKCI0.46618205
105PAK20.43870091
106RAF10.43338679
107CDK80.42024079
108MAPK100.41336554
109IRAK20.40487800
110BRD40.40379041
111SIK20.40367130
112STK30.40228503
113CSNK1E0.40001749
114LIMK10.39367135
115FLT30.39117095
116AURKB0.39007012
117PAK10.38958746
118STK380.36967864
119MAP2K60.36795338
120AKT30.36598863
121WEE10.35601806
122CDK10.35374553
123MAPK120.35321162
124MAP3K110.35259723
125SIK30.35016989
126PASK0.33907580
127KSR20.33167309
128KSR10.32034454
129PDK40.31769763
130PDK30.31769763
131TYK20.31472472
132MAPK150.31161753
133ILK0.31127195
134MAPK10.30409429
135GSK3B0.29330974
136PDGFRB0.28089646
137IGF1R0.27687224
138INSR0.27506653
139AURKA0.27281519
140SIK10.26801415
141PRKAA10.26760308
142MAPKAPK20.26639478
143ATR0.26271847
144MAPK140.25972970
145PAK30.25125878
146CDK150.23398667
147ERBB20.23166957
148CHUK0.21246396
149MAP3K30.20869467
150CDK11A0.19767398
151PIM10.19168846
152TESK20.19017855

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.03573817
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.21967062
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.75081323
4Fructose and mannose metabolism_Homo sapiens_hsa000512.79447810
5RNA transport_Homo sapiens_hsa030132.19260552
6mTOR signaling pathway_Homo sapiens_hsa041502.15920945
7Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.05376480
8Galactose metabolism_Homo sapiens_hsa000521.96788007
9mRNA surveillance pathway_Homo sapiens_hsa030151.82426935
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.77012482
11Thyroid cancer_Homo sapiens_hsa052161.69482462
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.67727745
13Cell cycle_Homo sapiens_hsa041101.66197392
14Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.43738718
15AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.42928302
16Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.40925211
17Central carbon metabolism in cancer_Homo sapiens_hsa052301.40320493
18One carbon pool by folate_Homo sapiens_hsa006701.40162842
19Lysosome_Homo sapiens_hsa041421.34722492
20MicroRNAs in cancer_Homo sapiens_hsa052061.31158377
21Prostate cancer_Homo sapiens_hsa052151.28247864
22Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.26836092
23ErbB signaling pathway_Homo sapiens_hsa040121.25127188
24Thyroid hormone signaling pathway_Homo sapiens_hsa049191.25019260
25Prion diseases_Homo sapiens_hsa050201.15462601
26ECM-receptor interaction_Homo sapiens_hsa045121.14686406
27Hepatitis B_Homo sapiens_hsa051611.13193765
28Arachidonic acid metabolism_Homo sapiens_hsa005901.13120546
29Phospholipase D signaling pathway_Homo sapiens_hsa040721.11901563
30Non-small cell lung cancer_Homo sapiens_hsa052231.10844897
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.09626303
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.07826804
33TNF signaling pathway_Homo sapiens_hsa046681.07798465
34Insulin signaling pathway_Homo sapiens_hsa049101.07716684
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.07256123
36Regulation of actin cytoskeleton_Homo sapiens_hsa048101.05946759
37Amoebiasis_Homo sapiens_hsa051461.05156667
38Inositol phosphate metabolism_Homo sapiens_hsa005621.05023629
39p53 signaling pathway_Homo sapiens_hsa041151.03478345
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.03034771
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.01172823
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00264381
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.99834503
44Hippo signaling pathway_Homo sapiens_hsa043900.99626354
45Acute myeloid leukemia_Homo sapiens_hsa052210.98496922
46Transcriptional misregulation in cancer_Homo sapiens_hsa052020.98068057
47Hepatitis C_Homo sapiens_hsa051600.98024560
48DNA replication_Homo sapiens_hsa030300.96039246
49Proteoglycans in cancer_Homo sapiens_hsa052050.95540647
50Bladder cancer_Homo sapiens_hsa052190.95354867
51Shigellosis_Homo sapiens_hsa051310.93673353
52RNA degradation_Homo sapiens_hsa030180.93618325
53Basal cell carcinoma_Homo sapiens_hsa052170.93575017
54Toll-like receptor signaling pathway_Homo sapiens_hsa046200.92731545
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92675366
56Fanconi anemia pathway_Homo sapiens_hsa034600.92614471
57Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.92469879
58Linoleic acid metabolism_Homo sapiens_hsa005910.91659755
59Small cell lung cancer_Homo sapiens_hsa052220.91295543
60Toxoplasmosis_Homo sapiens_hsa051450.91135182
61Prolactin signaling pathway_Homo sapiens_hsa049170.89279908
62Vibrio cholerae infection_Homo sapiens_hsa051100.88970924
63Pathways in cancer_Homo sapiens_hsa052000.88925381
64Influenza A_Homo sapiens_hsa051640.87537839
65Pancreatic cancer_Homo sapiens_hsa052120.87079997
66Adherens junction_Homo sapiens_hsa045200.86918058
67Viral carcinogenesis_Homo sapiens_hsa052030.86542778
68Fatty acid biosynthesis_Homo sapiens_hsa000610.85289648
69Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.85030820
70VEGF signaling pathway_Homo sapiens_hsa043700.84288330
71Spliceosome_Homo sapiens_hsa030400.83968420
72Osteoclast differentiation_Homo sapiens_hsa043800.83847037
73Estrogen signaling pathway_Homo sapiens_hsa049150.83149893
74Pentose phosphate pathway_Homo sapiens_hsa000300.80050957
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79778613
76Rap1 signaling pathway_Homo sapiens_hsa040150.79573115
77N-Glycan biosynthesis_Homo sapiens_hsa005100.77943122
78HTLV-I infection_Homo sapiens_hsa051660.77771943
79Choline metabolism in cancer_Homo sapiens_hsa052310.77589582
80Colorectal cancer_Homo sapiens_hsa052100.77506853
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.77382696
82AMPK signaling pathway_Homo sapiens_hsa041520.76268090
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.75826375
84Chronic myeloid leukemia_Homo sapiens_hsa052200.74850090
85Biosynthesis of amino acids_Homo sapiens_hsa012300.74694858
86Hedgehog signaling pathway_Homo sapiens_hsa043400.74533770
87Sphingolipid metabolism_Homo sapiens_hsa006000.72487687
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.70922751
89Lysine degradation_Homo sapiens_hsa003100.70901702
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.70621946
91Endocytosis_Homo sapiens_hsa041440.70560681
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70558946
93Notch signaling pathway_Homo sapiens_hsa043300.69913814
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.69798898
95Ovarian steroidogenesis_Homo sapiens_hsa049130.68766831
96Salmonella infection_Homo sapiens_hsa051320.68648045
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68618576
98Base excision repair_Homo sapiens_hsa034100.67469668
99Focal adhesion_Homo sapiens_hsa045100.67315982
100Tight junction_Homo sapiens_hsa045300.66989975
101NF-kappa B signaling pathway_Homo sapiens_hsa040640.65998220
102Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65754094
103RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.65629909
104Apoptosis_Homo sapiens_hsa042100.63520567
105Oocyte meiosis_Homo sapiens_hsa041140.63353215
106Endometrial cancer_Homo sapiens_hsa052130.62839142
107Herpes simplex infection_Homo sapiens_hsa051680.61600923
108Mismatch repair_Homo sapiens_hsa034300.61538885
109Leukocyte transendothelial migration_Homo sapiens_hsa046700.60023104
110Selenocompound metabolism_Homo sapiens_hsa004500.59658365
111Homologous recombination_Homo sapiens_hsa034400.57907866
112T cell receptor signaling pathway_Homo sapiens_hsa046600.56602025
113Melanoma_Homo sapiens_hsa052180.56178436
114FoxO signaling pathway_Homo sapiens_hsa040680.55304926
115B cell receptor signaling pathway_Homo sapiens_hsa046620.55294480
116Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53961673
117Measles_Homo sapiens_hsa051620.52648836
118Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51000639
119Epstein-Barr virus infection_Homo sapiens_hsa051690.50857752
120Dorso-ventral axis formation_Homo sapiens_hsa043200.50817382
121Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50775941
122Insulin resistance_Homo sapiens_hsa049310.50710722
123Wnt signaling pathway_Homo sapiens_hsa043100.50074439
124Glioma_Homo sapiens_hsa052140.49849934
1252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48520791
126Dilated cardiomyopathy_Homo sapiens_hsa054140.48372901
127Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48188511
128Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48115955
129Glycosaminoglycan degradation_Homo sapiens_hsa005310.48108444
130Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46941432
131Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46830979
132GnRH signaling pathway_Homo sapiens_hsa049120.46771652
133Carbon metabolism_Homo sapiens_hsa012000.46754106
134TGF-beta signaling pathway_Homo sapiens_hsa043500.45764358
135Other glycan degradation_Homo sapiens_hsa005110.44639953
136HIF-1 signaling pathway_Homo sapiens_hsa040660.44593434
137PI3K-Akt signaling pathway_Homo sapiens_hsa041510.44288359
138Adipocytokine signaling pathway_Homo sapiens_hsa049200.42905453
139Renal cell carcinoma_Homo sapiens_hsa052110.41328760
140Glycerophospholipid metabolism_Homo sapiens_hsa005640.41172756

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