HMGN5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nuclear protein with similarities to the high mobility group proteins, HMG14 and HMG17, which suggests that this protein may function as a nucleosomal binding and transcriptional activating protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1respiratory tube development (GO:0030323)8.86720313
2kidney morphogenesis (GO:0060993)7.68122180
3lung epithelium development (GO:0060428)7.55241211
4metanephric nephron tubule development (GO:0072234)7.31287091
5metanephric tubule development (GO:0072170)7.31287091
6lung-associated mesenchyme development (GO:0060484)7.20230356
7lens fiber cell development (GO:0070307)6.86774949
8metanephric nephron epithelium development (GO:0072243)6.52111922
9cartilage morphogenesis (GO:0060536)6.35243838
10collecting duct development (GO:0072044)6.26217016
11metanephric epithelium development (GO:0072207)6.08832145
12anatomical structure regression (GO:0060033)5.91052609
13lung morphogenesis (GO:0060425)5.35629214
14ribosomal small subunit assembly (GO:0000028)5.26075175
15kinetochore organization (GO:0051383)5.08678221
16mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.96893082
17CENP-A containing nucleosome assembly (GO:0034080)4.66582216
18maturation of SSU-rRNA (GO:0030490)4.65074826
19mitotic sister chromatid cohesion (GO:0007064)4.56136479
20chromatin remodeling at centromere (GO:0031055)4.54680002
21kinetochore assembly (GO:0051382)4.49423255
22mitotic metaphase plate congression (GO:0007080)4.43921923
23establishment of protein localization to mitochondrial membrane (GO:0090151)4.42548664
24viral transcription (GO:0019083)4.39858217
25chaperone-mediated protein transport (GO:0072321)4.38762271
26mitotic chromosome condensation (GO:0007076)4.35536354
27metaphase plate congression (GO:0051310)4.34295970
28DNA strand elongation involved in DNA replication (GO:0006271)4.34039106
29telomere maintenance via semi-conservative replication (GO:0032201)4.29272186
30nephron tubule development (GO:0072080)4.28465162
31translational termination (GO:0006415)4.24360027
32DNA strand elongation (GO:0022616)4.17775797
33DNA replication-independent nucleosome organization (GO:0034724)4.17042140
34DNA replication-independent nucleosome assembly (GO:0006336)4.17042140
35regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.15366206
36energy coupled proton transport, down electrochemical gradient (GO:0015985)4.15016250
37ATP synthesis coupled proton transport (GO:0015986)4.15016250
38ribosomal small subunit biogenesis (GO:0042274)4.12778060
39DNA unwinding involved in DNA replication (GO:0006268)4.09023104
40meiotic chromosome segregation (GO:0045132)4.07821239
41ribosomal large subunit biogenesis (GO:0042273)4.03068497
42DNA replication checkpoint (GO:0000076)4.02915915
43telomere maintenance via recombination (GO:0000722)4.02234201
44mitotic recombination (GO:0006312)4.01652265
45attachment of spindle microtubules to kinetochore (GO:0008608)3.98346695
46protein localization to kinetochore (GO:0034501)3.92813594
47protein localization to chromosome, centromeric region (GO:0071459)3.92611827
48histone exchange (GO:0043486)3.82548555
49renal tubule development (GO:0061326)3.78874687
50nonmotile primary cilium assembly (GO:0035058)3.78437975
51DNA replication initiation (GO:0006270)3.75349826
52establishment of chromosome localization (GO:0051303)3.73804351
53DNA topological change (GO:0006265)3.70986760
54mitotic sister chromatid segregation (GO:0000070)3.68693337
55SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.62479471
56double-strand break repair via nonhomologous end joining (GO:0006303)3.60778318
57non-recombinational repair (GO:0000726)3.60778318
58translational elongation (GO:0006414)3.60265100
59base-excision repair, AP site formation (GO:0006285)3.60208932
60cotranslational protein targeting to membrane (GO:0006613)3.55442974
61nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.54000563
62sister chromatid segregation (GO:0000819)3.53627858
63protein targeting to ER (GO:0045047)3.52218611
64translational initiation (GO:0006413)3.50568064
65replication fork processing (GO:0031297)3.50098629
66telomere maintenance via telomere lengthening (GO:0010833)3.48481124
67DNA ligation (GO:0006266)3.48267658
68mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.46018454
69exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.36898997
70nucleotide-excision repair, DNA gap filling (GO:0006297)3.33067125
71regulation of DNA endoreduplication (GO:0032875)3.32287493
72pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.31908638
73establishment of protein localization to endoplasmic reticulum (GO:0072599)3.31889299
74regulation of centriole replication (GO:0046599)3.31309360
75protein localization to endoplasmic reticulum (GO:0070972)3.30370772
76nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.29793988
77chromatin assembly or disassembly (GO:0006333)3.28242652
78nephron epithelium development (GO:0072009)3.25461042
79protein neddylation (GO:0045116)3.22641939
80viral life cycle (GO:0019058)3.21533605
81apoptotic process involved in morphogenesis (GO:0060561)3.20842341
82establishment of viral latency (GO:0019043)3.20369473
83ribonucleoprotein complex biogenesis (GO:0022613)3.19969488
84purine nucleobase biosynthetic process (GO:0009113)3.19406668
85V(D)J recombination (GO:0033151)3.18181395
86regulation of spindle organization (GO:0090224)3.17011735
87cellular protein complex disassembly (GO:0043624)3.16900810
88respiratory electron transport chain (GO:0022904)3.16497406
89ATP-dependent chromatin remodeling (GO:0043044)3.16334138
90axon ensheathment in central nervous system (GO:0032291)3.15060344
91central nervous system myelination (GO:0022010)3.15060344
92nucleobase biosynthetic process (GO:0046112)3.11387716
93negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.10232367
94centriole replication (GO:0007099)3.09029169
95electron transport chain (GO:0022900)3.08939102
96chromosome segregation (GO:0007059)3.07336116
97termination of RNA polymerase III transcription (GO:0006386)3.05201136
98transcription elongation from RNA polymerase III promoter (GO:0006385)3.05201136
99base-excision repair (GO:0006284)3.00646415
100maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.93979078
101intra-S DNA damage checkpoint (GO:0031573)2.90511290
102establishment of integrated proviral latency (GO:0075713)2.90255097
103formation of translation preinitiation complex (GO:0001731)2.90050551
104nuclear-transcribed mRNA catabolic process (GO:0000956)2.89359040
105negative regulation of RNA splicing (GO:0033119)2.88191747
106apoptotic process involved in development (GO:1902742)2.87221408
107protein complex disassembly (GO:0043241)2.87062654
108regulation of sister chromatid cohesion (GO:0007063)2.82451405
109rRNA processing (GO:0006364)2.80854518
110chromosome condensation (GO:0030261)2.79189248
111mRNA catabolic process (GO:0006402)2.76381234
112ribosome assembly (GO:0042255)2.76207131
113mitotic nuclear envelope disassembly (GO:0007077)2.76198187
114telomere maintenance (GO:0000723)2.75893913
115DNA packaging (GO:0006323)2.75726646
116negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.75569853
117inner mitochondrial membrane organization (GO:0007007)2.75504311
118regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.74307931
119telomere organization (GO:0032200)2.73679505
120negative regulation of DNA recombination (GO:0045910)2.72832779
121mitotic G2/M transition checkpoint (GO:0044818)2.72666845
122regulation of mitotic spindle organization (GO:0060236)2.72611996
123rRNA metabolic process (GO:0016072)2.72575726
124RNA catabolic process (GO:0006401)2.72509988
125DNA conformation change (GO:0071103)2.72129977
126negative regulation of mRNA processing (GO:0050686)2.70877137
127tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.70247897
128RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.70247897
129negative regulation of cell cycle G2/M phase transition (GO:1902750)2.69806310
130pyrimidine nucleotide catabolic process (GO:0006244)2.69099209
131macromolecular complex disassembly (GO:0032984)2.68606157
132protein complex biogenesis (GO:0070271)2.68317199
133DNA deamination (GO:0045006)2.68239572
134mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.67562744
135mitochondrial respiratory chain complex I assembly (GO:0032981)2.67562744
136NADH dehydrogenase complex assembly (GO:0010257)2.67562744
137negative regulation of DNA-dependent DNA replication (GO:2000104)2.67298116
138proteasome assembly (GO:0043248)2.67066238
139DNA replication-dependent nucleosome assembly (GO:0006335)2.65094229
140DNA replication-dependent nucleosome organization (GO:0034723)2.65094229
141regulation of centrosome cycle (GO:0046605)2.64135628
142RNA splicing, via transesterification reactions (GO:0000375)2.63479286
143translation (GO:0006412)2.63209464
144translesion synthesis (GO:0019985)2.62269573
145RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.61401556
146mRNA splicing, via spliceosome (GO:0000398)2.61401556
147sister chromatid cohesion (GO:0007062)2.61136876
148transcription-coupled nucleotide-excision repair (GO:0006283)2.60066433
149DNA duplex unwinding (GO:0032508)2.59902737
150DNA geometric change (GO:0032392)2.59882488
151negative regulation of DNA-templated transcription, elongation (GO:0032785)2.58653863
152negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.58653863
153regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.58129218
154folic acid-containing compound biosynthetic process (GO:0009396)2.57974237
155somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.57734730
156isotype switching (GO:0045190)2.57734730
157somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.57734730

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.89810737
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.23650213
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.39420130
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.16708767
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.99970549
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.40762293
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.37750739
8AR_21909140_ChIP-Seq_LNCAP_Human2.98326751
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.85083981
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.81768117
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.66565894
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.53041010
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.46240793
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.35237082
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.35083074
16E2F1_21310950_ChIP-Seq_MCF-7_Human2.34287906
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.29877830
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.24385953
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.19724470
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.13211451
21XRN2_22483619_ChIP-Seq_HELA_Human2.09162920
22VDR_23849224_ChIP-Seq_CD4+_Human2.08453989
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.06329739
24FOXP3_21729870_ChIP-Seq_TREG_Human2.05678125
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.02975130
26POU5F1_16153702_ChIP-ChIP_HESCs_Human2.02007276
27EGR1_19374776_ChIP-ChIP_THP-1_Human1.91587491
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.90916374
29ELK1_19687146_ChIP-ChIP_HELA_Human1.90213833
30TP63_19390658_ChIP-ChIP_HaCaT_Human1.88858620
31ZNF274_21170338_ChIP-Seq_K562_Hela1.88327827
32TTF2_22483619_ChIP-Seq_HELA_Human1.88205150
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.87077534
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.78701539
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.78009467
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.73079368
37E2F1_18555785_ChIP-Seq_MESCs_Mouse1.70737572
38KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.70314634
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67244842
40MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.66150336
41HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.65721134
42TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.64627169
43DCP1A_22483619_ChIP-Seq_HELA_Human1.62397407
44ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.62239823
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.61853644
46EGR1_23403033_ChIP-Seq_LIVER_Mouse1.61480155
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.60248203
48SOX2_16153702_ChIP-ChIP_HESCs_Human1.54673740
49EZH2_22144423_ChIP-Seq_EOC_Human1.53504084
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.51035552
51* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.50739215
52CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.48354138
53MYCN_18555785_ChIP-Seq_MESCs_Mouse1.46876235
54MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.43235370
55* FUS_26573619_Chip-Seq_HEK293_Human1.42916569
56NANOG_16153702_ChIP-ChIP_HESCs_Human1.42913012
57GABP_19822575_ChIP-Seq_HepG2_Human1.42827844
58TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.42734584
59PADI4_21655091_ChIP-ChIP_MCF-7_Human1.37197451
60HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.36218281
61CBX2_27304074_Chip-Seq_ESCs_Mouse1.35830005
62KDM5A_27292631_Chip-Seq_BREAST_Human1.34575812
63YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33998947
64HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.29620156
65ERG_20887958_ChIP-Seq_HPC-7_Mouse1.28269296
66CIITA_25753668_ChIP-Seq_RAJI_Human1.28010652
67YY1_21170310_ChIP-Seq_MESCs_Mouse1.27251602
68SRF_21415370_ChIP-Seq_HL-1_Mouse1.22170306
69ZFX_18555785_ChIP-Seq_MESCs_Mouse1.21821227
70SCL_19346495_ChIP-Seq_HPC-7_Human1.19481737
71NOTCH1_21737748_ChIP-Seq_TLL_Human1.17788414
72E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14925239
73NANOG_18555785_ChIP-Seq_MESCs_Mouse1.12850739
74POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.11209192
75CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.09913819
76SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09302932
77MYC_18940864_ChIP-ChIP_HL60_Human1.08608032
78RXR_22158963_ChIP-Seq_LIVER_Mouse1.08200450
79KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07064348
80P300_19829295_ChIP-Seq_ESCs_Human1.06675352
81IGF1R_20145208_ChIP-Seq_DFB_Human1.06398322
82MYC_22102868_ChIP-Seq_BL_Human1.05726672
83* RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05690499
84GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.04666469
85VDR_22108803_ChIP-Seq_LS180_Human1.03614617
86PPARA_22158963_ChIP-Seq_LIVER_Mouse1.03245227
87EZH2_27304074_Chip-Seq_ESCs_Mouse0.99622340
88ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.99073726
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98936995
90CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98040434
91FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.97339951
92* TAF15_26573619_Chip-Seq_HEK293_Human0.97175655
93RBPJ_22232070_ChIP-Seq_NCS_Mouse0.97077218
94IRF1_19129219_ChIP-ChIP_H3396_Human0.95318158
95ZFP57_27257070_Chip-Seq_ESCs_Mouse0.94355451
96RNF2_27304074_Chip-Seq_NSC_Mouse0.93894188
97ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93811029
98BMI1_23680149_ChIP-Seq_NPCS_Mouse0.93704135
99ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.92711291
100THAP11_20581084_ChIP-Seq_MESCs_Mouse0.90892403
101PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90755939
102SPI1_23547873_ChIP-Seq_NB4_Human0.90272442
103SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.89842526
104MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.89279692
105EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.87067473
106POU3F2_20337985_ChIP-ChIP_501MEL_Human0.86274589
107IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.84936777
108BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.84669080
109GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84590455
110ELK1_22589737_ChIP-Seq_MCF10A_Human0.82766162
111CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.81175171
112ESR1_15608294_ChIP-ChIP_MCF-7_Human0.80561519
113MYB_26560356_Chip-Seq_TH1_Human0.79797541
114* LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79337706
115PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.78802832
116CTBP2_25329375_ChIP-Seq_LNCAP_Human0.78338138
117FLI1_27457419_Chip-Seq_LIVER_Mouse0.78046112
118SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.77587934
119POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.77335086
120SOX2_18555785_ChIP-Seq_MESCs_Mouse0.77278938
121KLF4_18555785_ChIP-Seq_MESCs_Mouse0.75847893
122* GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75351953
123KAP1_22055183_ChIP-Seq_ESCs_Mouse0.75334986
124SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.74338755
125CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.73340979
126TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.71603578
127NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.71295870
128STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.71255910
129STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.71245226
130FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.71011649
131MYB_21317192_ChIP-Seq_ERMYB_Mouse0.69689942
132* EWS_26573619_Chip-Seq_HEK293_Human0.68829026
133RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.68655698
134DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.68187121
135TCF3_18692474_ChIP-Seq_MEFs_Mouse0.68020829
136BCAT_22108803_ChIP-Seq_LS180_Human0.66741247
137FOXA1_25329375_ChIP-Seq_VCAP_Human0.66612549
138FOXA1_27270436_Chip-Seq_PROSTATE_Human0.66612549
139PHF8_20622853_ChIP-Seq_HELA_Human0.66529925
140ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.65862911
141UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.64028379
142SOX2_18692474_ChIP-Seq_MEFs_Mouse0.63356476

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.86924930
2MP0005248_abnormal_Harderian_gland4.56050793
3MP0005646_abnormal_pituitary_gland4.38075326
4MP0010094_abnormal_chromosome_stability3.77450917
5MP0003111_abnormal_nucleus_morphology3.45203746
6MP0004957_abnormal_blastocyst_morpholog3.37785922
7MP0002653_abnormal_ependyma_morphology3.30019681
8MP0002102_abnormal_ear_morphology3.18361908
9MP0003077_abnormal_cell_cycle3.00526500
10MP0009379_abnormal_foot_pigmentation2.91584154
11MP0008057_abnormal_DNA_replication2.85218703
12MP0000566_synostosis2.77535989
13MP0002396_abnormal_hematopoietic_system2.55345207
14MP0005360_urolithiasis2.34487849
15MP0008058_abnormal_DNA_repair2.31254800
16MP0008007_abnormal_cellular_replicative2.24767345
17MP0005365_abnormal_bile_salt2.19353804
18MP0009278_abnormal_bone_marrow2.16992249
19MP0002139_abnormal_hepatobiliary_system2.16968273
20MP0003283_abnormal_digestive_organ2.14417153
21MP0005085_abnormal_gallbladder_physiolo2.14200973
22MP0003315_abnormal_perineum_morphology2.03335389
23MP0008932_abnormal_embryonic_tissue1.70157111
24MP0003186_abnormal_redox_activity1.61297416
25MP0001730_embryonic_growth_arrest1.60861765
26MP0000490_abnormal_crypts_of1.58785235
27MP0006292_abnormal_olfactory_placode1.55320059
28MP0003806_abnormal_nucleotide_metabolis1.54964763
29MP0008877_abnormal_DNA_methylation1.54152796
30MP0002295_abnormal_pulmonary_circulatio1.53429032
31MP0005408_hypopigmentation1.51579943
32MP0008875_abnormal_xenobiotic_pharmacok1.50982042
33MP0003123_paternal_imprinting1.48374912
34MP0003136_yellow_coat_color1.46873462
35MP0008789_abnormal_olfactory_epithelium1.43638159
36MP0000350_abnormal_cell_proliferation1.41251380
37MP0001286_abnormal_eye_development1.39959294
38MP0001485_abnormal_pinna_reflex1.37083317
39MP0001672_abnormal_embryogenesis/_devel1.25047305
40MP0005380_embryogenesis_phenotype1.25047305
41MP0005499_abnormal_olfactory_system1.25039601
42MP0005394_taste/olfaction_phenotype1.25039601
43MP0003718_maternal_effect1.24830247
44MP0004885_abnormal_endolymph1.20395671
45MP0003984_embryonic_growth_retardation1.20286778
46MP0002088_abnormal_embryonic_growth/wei1.17492547
47MP0004808_abnormal_hematopoietic_stem1.17249970
48MP0009697_abnormal_copulation1.15961015
49MP0002092_abnormal_eye_morphology1.15048362
50MP0005195_abnormal_posterior_eye1.14164694
51MP0005220_abnormal_exocrine_pancreas1.13280286
52MP0003950_abnormal_plasma_membrane1.12878119
53MP0003567_abnormal_fetal_cardiomyocyte1.12322936
54MP0001188_hyperpigmentation1.11754829
55MP0006072_abnormal_retinal_apoptosis1.11323912
56MP0003786_premature_aging1.11101247
57MP0004264_abnormal_extraembryonic_tissu1.10468470
58MP0001697_abnormal_embryo_size1.10046574
59MP0000778_abnormal_nervous_system1.09853890
60MP0002938_white_spotting1.09836137
61MP0001545_abnormal_hematopoietic_system1.08337634
62MP0005397_hematopoietic_system_phenotyp1.08337634
63MP0002009_preneoplasia1.07946427
64MP0002019_abnormal_tumor_incidence1.07803442
65MP0005187_abnormal_penis_morphology1.06897349
66MP0001346_abnormal_lacrimal_gland1.06447923
67MP0005174_abnormal_tail_pigmentation1.05586538
68MP0000313_abnormal_cell_death1.04917946
69MP0003115_abnormal_respiratory_system0.99007581
70MP0005391_vision/eye_phenotype0.98904798
71MP0010307_abnormal_tumor_latency0.98280678
72MP0002086_abnormal_extraembryonic_tissu0.97966150
73MP0000631_abnormal_neuroendocrine_gland0.97818965
74MP0000026_abnormal_inner_ear0.97781168
75MP0001529_abnormal_vocalization0.97382410
76MP0009053_abnormal_anal_canal0.97068931
77MP0001119_abnormal_female_reproductive0.96122762
78MP0002837_dystrophic_cardiac_calcinosis0.95278016
79MP0004133_heterotaxia0.94135000
80MP0002084_abnormal_developmental_patter0.90329352
81MP0002080_prenatal_lethality0.90215259
82MP0002736_abnormal_nociception_after0.89981770
83MP0009840_abnormal_foam_cell0.89663832
84MP0002085_abnormal_embryonic_tissue0.88925696
85MP0002210_abnormal_sex_determination0.88321042
86MP0003763_abnormal_thymus_physiology0.86596814
87MP0003011_delayed_dark_adaptation0.86178954
88MP0002098_abnormal_vibrissa_morphology0.85205767
89MP0002697_abnormal_eye_size0.85176633
90MP0002233_abnormal_nose_morphology0.84998374
91MP0005551_abnormal_eye_electrophysiolog0.84860148
92MP0003252_abnormal_bile_duct0.84129333
93MP0000613_abnormal_salivary_gland0.83078753
94MP0010030_abnormal_orbit_morphology0.82713314
95MP0001764_abnormal_homeostasis0.81916897
96MP0004381_abnormal_hair_follicle0.81119057
97MP0003890_abnormal_embryonic-extraembry0.80598828
98MP0003121_genomic_imprinting0.80416400
99MP0001666_abnormal_nutrient_absorption0.80367568
100MP0009672_abnormal_birth_weight0.79826863
101MP0005197_abnormal_uvea_morphology0.79582614
102MP0000858_altered_metastatic_potential0.79047080
103MP0000049_abnormal_middle_ear0.79008338
104MP0003943_abnormal_hepatobiliary_system0.77922671
105MP0002132_abnormal_respiratory_system0.77002733
106MP0002095_abnormal_skin_pigmentation0.76395894
107MP0009046_muscle_twitch0.76346437
108MP0002876_abnormal_thyroid_physiology0.76345742
109MP0000653_abnormal_sex_gland0.76226875
110MP0006036_abnormal_mitochondrial_physio0.76160353
111MP0004197_abnormal_fetal_growth/weight/0.76024620
112MP0003122_maternal_imprinting0.75440932
113MP0003119_abnormal_digestive_system0.75130627
114MP0010352_gastrointestinal_tract_polyps0.74340817
115MP0003938_abnormal_ear_development0.73898539
116MP0002234_abnormal_pharynx_morphology0.73694771
117MP0001853_heart_inflammation0.73019679
118MP0002163_abnormal_gland_morphology0.72830877
119MP0000703_abnormal_thymus_morphology0.72333102
120MP0001145_abnormal_male_reproductive0.72156790
121MP0003787_abnormal_imprinting0.72152936
122MP0002272_abnormal_nervous_system0.71570534
123MP0004742_abnormal_vestibular_system0.71538360
124MP0004142_abnormal_muscle_tone0.71467904
125MP0005075_abnormal_melanosome_morpholog0.71284538
126MP0001984_abnormal_olfaction0.70229213
127MP0002166_altered_tumor_susceptibility0.69990622
128MP0002722_abnormal_immune_system0.69687253
129MP0003221_abnormal_cardiomyocyte_apopto0.69562977
130MP0001849_ear_inflammation0.69372351
131MP0001293_anophthalmia0.69090721
132MP0005451_abnormal_body_composition0.68829919
133MP0002752_abnormal_somatic_nervous0.68569148
134MP0003861_abnormal_nervous_system0.68289110
135MP0003937_abnormal_limbs/digits/tail_de0.67578651
136MP0008770_decreased_survivor_rate0.67103887
137MP0002398_abnormal_bone_marrow0.66919981
138MP0002277_abnormal_respiratory_mucosa0.66724543
139MP0008995_early_reproductive_senescence0.66522566
140MP0002116_abnormal_craniofacial_bone0.65397516
141MP0008872_abnormal_physiological_respon0.65169704
142MP0001929_abnormal_gametogenesis0.65087390
143MP0000598_abnormal_liver_morphology0.64260008
144MP0002160_abnormal_reproductive_system0.64231309
145MP0002111_abnormal_tail_morphology0.64194766
146MP0003699_abnormal_female_reproductive0.64117218
147MP0001324_abnormal_eye_pigmentation0.63799273
148MP0003868_abnormal_feces_composition0.63577073
149MP0003941_abnormal_skin_development0.63437775
150MP0001486_abnormal_startle_reflex0.62688915
151MP0005253_abnormal_eye_physiology0.62058804
152MP0001663_abnormal_digestive_system0.61685653
153MP0002638_abnormal_pupillary_reflex0.61548064
154MP0000015_abnormal_ear_pigmentation0.61113564
155MP0003632_abnormal_nervous_system0.59719519
156MP0003698_abnormal_male_reproductive0.56931213
157MP0003936_abnormal_reproductive_system0.56773078
158MP0001963_abnormal_hearing_physiology0.56607650
159MP0000647_abnormal_sebaceous_gland0.52726694

Predicted human phenotypes

RankGene SetZ-score
1Dyschromatopsia (HP:0007641)5.12666410
2True hermaphroditism (HP:0010459)5.04437699
3Decreased central vision (HP:0007663)4.80766226
4Reticulocytopenia (HP:0001896)4.72756857
5Abnormality of cells of the erythroid lineage (HP:0012130)4.09061970
6Pancreatic fibrosis (HP:0100732)4.05163017
7Abnormal number of erythroid precursors (HP:0012131)3.94484706
8Oral leukoplakia (HP:0002745)3.82434978
9Acute necrotizing encephalopathy (HP:0006965)3.69769952
10Chromsome breakage (HP:0040012)3.67057161
11Pancreatic cysts (HP:0001737)3.39048765
12Abnormality of chromosome stability (HP:0003220)3.31331437
13Aplastic anemia (HP:0001915)3.30041525
14Macrocytic anemia (HP:0001972)3.27994957
15Colon cancer (HP:0003003)3.23458615
16Abnormal hemoglobin (HP:0011902)3.15995142
17Anencephaly (HP:0002323)3.14785471
18Abnormal mitochondria in muscle tissue (HP:0008316)3.13556145
19Volvulus (HP:0002580)3.12994165
20Abnormality of the preputium (HP:0100587)3.12651042
21Acute encephalopathy (HP:0006846)3.11990506
22Maternal diabetes (HP:0009800)3.07997793
23Mitochondrial inheritance (HP:0001427)3.07095659
24Progressive macrocephaly (HP:0004481)3.07055297
25Pallor (HP:0000980)3.02390920
26Septo-optic dysplasia (HP:0100842)2.97716899
27Hyperglycinemia (HP:0002154)2.97052190
28Chromosomal breakage induced by crosslinking agents (HP:0003221)2.96778225
29Birth length less than 3rd percentile (HP:0003561)2.88722596
30Sclerocornea (HP:0000647)2.83597536
31Renal cortical cysts (HP:0000803)2.81507574
32Lip pit (HP:0100267)2.80008545
33Impulsivity (HP:0100710)2.78948469
34Molar tooth sign on MRI (HP:0002419)2.78808412
35Abnormality of midbrain morphology (HP:0002418)2.78808412
36Increased CSF lactate (HP:0002490)2.76590734
37Abnormal sex determination (HP:0012244)2.74762745
38Sex reversal (HP:0012245)2.74762745
39Abnormality of pyrimidine metabolism (HP:0004353)2.70223687
40Neoplasm of the adrenal cortex (HP:0100641)2.69948393
41Nephronophthisis (HP:0000090)2.64928159
42Renal Fanconi syndrome (HP:0001994)2.62035757
43Male pseudohermaphroditism (HP:0000037)2.59044145
44Myelodysplasia (HP:0002863)2.58460046
45Anophthalmia (HP:0000528)2.53001615
46Squamous cell carcinoma (HP:0002860)2.52323312
47Abnormality of cochlea (HP:0000375)2.52236556
48Aplasia/Hypoplasia of the tongue (HP:0010295)2.48965152
49Acute myeloid leukemia (HP:0004808)2.48734842
5011 pairs of ribs (HP:0000878)2.48648582
51Holoprosencephaly (HP:0001360)2.47925523
52Abnormality of monocarboxylic acid metabolism (HP:0010996)2.47585722
53Abnormality of the labia minora (HP:0012880)2.44770981
54Thrombocytosis (HP:0001894)2.42380916
55Congenital, generalized hypertrichosis (HP:0004540)2.38511923
56Cystic liver disease (HP:0006706)2.36661636
57Intrahepatic cholestasis (HP:0001406)2.36255984
58Rough bone trabeculation (HP:0100670)2.31346697
59Ectopic kidney (HP:0000086)2.30715986
60Meckel diverticulum (HP:0002245)2.28864282
61Abnormality of the renal medulla (HP:0100957)2.27903539
62Patellar aplasia (HP:0006443)2.27817916
63Medulloblastoma (HP:0002885)2.27624454
64Cerebral edema (HP:0002181)2.24514884
65Breast hypoplasia (HP:0003187)2.22388353
66Abnormality of the heme biosynthetic pathway (HP:0010472)2.20531748
67Abnormality of aromatic amino acid family metabolism (HP:0004338)2.19880362
68Aplasia/Hypoplasia of the patella (HP:0006498)2.19417743
69Increased nuchal translucency (HP:0010880)2.17710612
70Hepatocellular necrosis (HP:0001404)2.16328685
71Furrowed tongue (HP:0000221)2.16021945
72Morphological abnormality of the inner ear (HP:0011390)2.14617749
73Abolished electroretinogram (ERG) (HP:0000550)2.14141225
74Pendular nystagmus (HP:0012043)2.13054012
75Abnormal spermatogenesis (HP:0008669)2.12716634
76Horseshoe kidney (HP:0000085)2.11884368
77Abnormality of renal resorption (HP:0011038)2.11582968
78Hepatoblastoma (HP:0002884)2.11089709
79Methylmalonic acidemia (HP:0002912)2.10401030
80Abnormal number of incisors (HP:0011064)2.08850506
81Medial flaring of the eyebrow (HP:0010747)2.08370052
82Hypobetalipoproteinemia (HP:0003563)2.08086250
83Postaxial foot polydactyly (HP:0001830)2.07868554
84Exertional dyspnea (HP:0002875)2.07159217
85Abnormality of the ileum (HP:0001549)2.06590161
86Aplasia/Hypoplasia of the uvula (HP:0010293)2.06280340
87Abnormality of the prostate (HP:0008775)2.04929471
88Aplasia/Hypoplasia of the sacrum (HP:0008517)2.04590722
89Oligodactyly (hands) (HP:0001180)2.03747221
90Abnormality of the septum pellucidum (HP:0007375)2.02420456
91Reduced antithrombin III activity (HP:0001976)2.01850368
92Pancytopenia (HP:0001876)2.01382954
93Myokymia (HP:0002411)2.00755025
94Absent septum pellucidum (HP:0001331)2.00475340
95Absent thumb (HP:0009777)1.99771236
96Abnormality of reticulocytes (HP:0004312)1.98814443
97Abnormality of the renal collecting system (HP:0004742)1.97942124
98Bone marrow hypocellularity (HP:0005528)1.97457118
99Increased intramyocellular lipid droplets (HP:0012240)1.95888187
100Hypochromic microcytic anemia (HP:0004840)1.95303873
101Rhabdomyosarcoma (HP:0002859)1.95136681
102Sloping forehead (HP:0000340)1.95098107
103Absent rod-and cone-mediated responses on ERG (HP:0007688)1.95016091
104Abnormal lung lobation (HP:0002101)1.94071147
105Spinal muscular atrophy (HP:0007269)1.94047404
106Hyperglycinuria (HP:0003108)1.93873883
107Blepharitis (HP:0000498)1.93672535
108Hepatic necrosis (HP:0002605)1.93444244
109Small intestinal stenosis (HP:0012848)1.92683720
110Duodenal stenosis (HP:0100867)1.92683720
111Premature graying of hair (HP:0002216)1.92235739
112Abnormality of glycine metabolism (HP:0010895)1.91204204
113Abnormality of serine family amino acid metabolism (HP:0010894)1.91204204
114Nausea (HP:0002018)1.90872705
115Azoospermia (HP:0000027)1.90395932
116Abnormal trabecular bone morphology (HP:0100671)1.89750546
117Secondary amenorrhea (HP:0000869)1.88760087
118Rectal prolapse (HP:0002035)1.88445899
119Leukodystrophy (HP:0002415)1.86874156
120Stenosis of the external auditory canal (HP:0000402)1.86328888
121Triphalangeal thumb (HP:0001199)1.86170107
122Prolonged partial thromboplastin time (HP:0003645)1.86158283
123Poikiloderma (HP:0001029)1.84871325
124Preaxial hand polydactyly (HP:0001177)1.84056034
125Pulmonary fibrosis (HP:0002206)1.83489315
126Atresia of the external auditory canal (HP:0000413)1.82929534
127Sparse eyelashes (HP:0000653)1.81942826
128Hypochromic anemia (HP:0001931)1.81398036
129Neoplasm of the adrenal gland (HP:0100631)1.81127178
130Abnormality of lateral ventricle (HP:0030047)1.80231082
131Clubbing of toes (HP:0100760)1.80160304
132Methylmalonic aciduria (HP:0012120)1.80007719
133Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.79483567
134Megaloblastic anemia (HP:0001889)1.78591518
135Abnormality of the intervertebral disk (HP:0005108)1.77687958
136Microretrognathia (HP:0000308)1.76414905
137Dandy-Walker malformation (HP:0001305)1.76178958
138Scrotal hypoplasia (HP:0000046)1.76007699
139Long foot (HP:0001833)1.75237919
140Cellular immunodeficiency (HP:0005374)1.74666810
141Conjugated hyperbilirubinemia (HP:0002908)1.74255945
142Partial duplication of thumb phalanx (HP:0009944)1.74148769
143Respiratory failure (HP:0002878)1.73980003
144Abnormality of the fingertips (HP:0001211)1.73088956
145Lipid accumulation in hepatocytes (HP:0006561)1.72824356
146Increased hepatocellular lipid droplets (HP:0006565)1.72288615
147Abnormality of the duodenum (HP:0002246)1.71345975
148IgM deficiency (HP:0002850)1.70628938
149Diastasis recti (HP:0001540)1.69330833
150Congenital primary aphakia (HP:0007707)1.67863431
151Optic disc pallor (HP:0000543)1.67596118
152Optic nerve coloboma (HP:0000588)1.66651127
153Abnormality of the renal cortex (HP:0011035)1.66348530
154Abnormal biliary tract morphology (HP:0012440)1.66304568
155Selective tooth agenesis (HP:0001592)1.65892257
156Increased serum lactate (HP:0002151)1.64849076
157Abnormality of serum amino acid levels (HP:0003112)1.64778546
158Carpal bone hypoplasia (HP:0001498)1.63687374
159Oligodactyly (HP:0012165)1.61225250
160Nephroblastoma (Wilms tumor) (HP:0002667)1.60958265
161Depressed nasal ridge (HP:0000457)1.58795262
162Lymphoma (HP:0002665)1.57666219
163Neoplasm of the pancreas (HP:0002894)1.56785786
164Abnormality of the carotid arteries (HP:0005344)1.55973628
165Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.55151160
166Aplasia/Hypoplasia of the thymus (HP:0010515)1.54526266
167Acute lymphatic leukemia (HP:0006721)1.53824097
168Tracheoesophageal fistula (HP:0002575)1.53750605
169Hypoplasia of the radius (HP:0002984)1.53409359
170Neoplasm of the colon (HP:0100273)1.51215499
171Hypoglycemic coma (HP:0001325)1.49255603

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.74599158
2WEE13.04390442
3SRPK12.99667952
4PLK42.99146134
5NEK22.93291732
6EIF2AK12.77239855
7VRK22.74655778
8TNIK2.69800542
9STK162.60096616
10MKNK12.58480197
11MKNK22.43322834
12BUB12.39695585
13CDK82.35552570
14ACVR1B2.25663687
15BRSK22.24650422
16CDK122.21493928
17TTK2.18034915
18PNCK1.93647758
19CDK71.91885509
20WNK31.89919453
21* AURKB1.89399335
22EIF2AK31.85187114
23NUAK11.78742932
24PLK11.69232587
25BCR1.65695772
26VRK11.61815619
27CDK41.59930565
28RPS6KA41.58055134
29ATR1.55330154
30PBK1.55306406
31CDK61.53153150
32CHEK21.47952080
33DYRK21.46878759
34TGFBR11.43865128
35STK41.39656215
36PLK31.36850183
37TAF11.36695394
38NME21.34627163
39PRKD31.31700026
40MST41.29693194
41LATS11.28092075
42DYRK31.27961913
43EIF2AK21.27624150
44TRIM281.27092441
45STK101.25688608
46BRSK11.25001626
47TEC1.24433836
48PLK21.24298018
49BRD41.21014718
50NEK11.17924706
51PASK1.16925624
52RPS6KB21.15050622
53FRK1.14682974
54TAOK31.11864403
55CHEK11.07890426
56GRK11.07090694
57MAP4K21.05437022
58DYRK1B1.02229505
59MAP2K31.01846864
60ATM1.01135468
61STK31.00191543
62INSRR0.98986874
63MELK0.98206365
64IRAK30.94695567
65CDK190.92927423
66IRAK40.92707835
67CSNK1G20.91825970
68NME10.88781274
69EPHA40.86218418
70FGFR20.83215608
71STK38L0.81677950
72PRKD20.79636108
73AURKA0.78285610
74MAPK130.75901837
75BMPR1B0.75480283
76MAP3K40.75137090
77* CDK20.74763286
78PRKCH0.70847993
79UHMK10.69839525
80NLK0.69599269
81CSNK2A10.69271625
82PINK10.67328775
83CSNK2A20.66902567
84PIM10.63992051
85TSSK60.63775591
86MAP2K60.63415647
87PRKCG0.62762545
88TRPM70.62756357
89LRRK20.62672769
90NEK90.62014126
91CSNK1G10.61524456
92ADRBK20.59610042
93BTK0.59307538
94* CDK10.58186046
95MAP3K80.57542162
96CDK90.57181516
97CCNB10.56935378
98PRKG20.54664983
99CAMK1G0.53759660
100GRK50.52101057
101KDR0.51849932
102ALK0.50975212
103CSNK1A10.49931813
104BCKDK0.49575360
105PKN20.49507322
106CSNK1G30.48176488
107CSNK1E0.46739303
108TLK10.46735704
109PIK3CG0.46481119
110CASK0.46293425
111CAMK10.46240055
112OXSR10.44893658
113PRKCE0.44381046
114PIM20.44289918
115FLT30.43295567
116ZAK0.43145711
117ADRBK10.42799439
118YES10.42111638
119MAP4K10.41851426
120CDK30.40704908
121MAPK110.39600124
122ABL20.37305077
123RPS6KA50.37269394
124PRKACB0.36404311
125MAPKAPK20.35978428
126MAP2K70.35846446
127PRKACA0.35744191
128TIE10.35629617
129MAPK140.35239940
130CAMK2A0.32728304
131TXK0.32504295
132ILK0.32336129
133AKT20.28982451
134MAPK150.28066155
135MST1R0.27347329
136PAK40.27276620
137CAMK1D0.26881820
138LMTK20.26862460
139STK110.26170528
140STK240.25682779
141MARK30.25595873
142MAP3K60.24563678
143PRKDC0.24400502
144AKT10.24224204
145KIT0.22600495
146ERBB20.22438022
147SIK30.22261377

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.34957334
2Mismatch repair_Homo sapiens_hsa034303.89283407
3Ribosome_Homo sapiens_hsa030103.78874943
4Homologous recombination_Homo sapiens_hsa034403.24856382
5Oxidative phosphorylation_Homo sapiens_hsa001903.10162388
6Spliceosome_Homo sapiens_hsa030402.79970016
7RNA polymerase_Homo sapiens_hsa030202.48863457
8Base excision repair_Homo sapiens_hsa034102.47601869
9Nucleotide excision repair_Homo sapiens_hsa034202.39266334
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.30630288
11Cell cycle_Homo sapiens_hsa041102.29864797
12Pyrimidine metabolism_Homo sapiens_hsa002402.19829761
13RNA transport_Homo sapiens_hsa030132.19796277
14Non-homologous end-joining_Homo sapiens_hsa034502.18092445
15Hedgehog signaling pathway_Homo sapiens_hsa043402.16499379
16Basal transcription factors_Homo sapiens_hsa030222.16474395
17One carbon pool by folate_Homo sapiens_hsa006702.13306171
18Fanconi anemia pathway_Homo sapiens_hsa034602.11811779
19Proteasome_Homo sapiens_hsa030501.97745106
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.97076214
21RNA degradation_Homo sapiens_hsa030181.81026190
22Basal cell carcinoma_Homo sapiens_hsa052171.80776302
23Folate biosynthesis_Homo sapiens_hsa007901.70727430
24Alzheimers disease_Homo sapiens_hsa050101.69198386
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.56742804
26Pentose and glucuronate interconversions_Homo sapiens_hsa000401.52389474
27Primary bile acid biosynthesis_Homo sapiens_hsa001201.46550431
28Cardiac muscle contraction_Homo sapiens_hsa042601.43275586
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.23930886
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.22808378
31mRNA surveillance pathway_Homo sapiens_hsa030151.21991413
32Caffeine metabolism_Homo sapiens_hsa002321.21338267
33p53 signaling pathway_Homo sapiens_hsa041151.19312075
34Cyanoamino acid metabolism_Homo sapiens_hsa004601.19201363
35Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.17359332
36Protein export_Homo sapiens_hsa030601.13243486
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11563589
38Purine metabolism_Homo sapiens_hsa002301.04198985
39Tryptophan metabolism_Homo sapiens_hsa003801.03849237
40Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.02027805
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.01667865
42Selenocompound metabolism_Homo sapiens_hsa004501.01470902
43Sulfur relay system_Homo sapiens_hsa041220.99857577
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.99796429
45Cysteine and methionine metabolism_Homo sapiens_hsa002700.98648099
46Steroid hormone biosynthesis_Homo sapiens_hsa001400.98319407
47Chemical carcinogenesis_Homo sapiens_hsa052040.95837288
48Glutathione metabolism_Homo sapiens_hsa004800.92459931
49Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.92354083
50Herpes simplex infection_Homo sapiens_hsa051680.92315628
51Histidine metabolism_Homo sapiens_hsa003400.92282915
52Lysine degradation_Homo sapiens_hsa003100.91046667
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90229159
54Fatty acid degradation_Homo sapiens_hsa000710.90152841
55Retinol metabolism_Homo sapiens_hsa008300.90102090
56Maturity onset diabetes of the young_Homo sapiens_hsa049500.89612317
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.86511454
58Peroxisome_Homo sapiens_hsa041460.83703552
59beta-Alanine metabolism_Homo sapiens_hsa004100.81419248
60Wnt signaling pathway_Homo sapiens_hsa043100.79897040
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.79484255
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73603865
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.72095372
64Linoleic acid metabolism_Homo sapiens_hsa005910.71562625
65Steroid biosynthesis_Homo sapiens_hsa001000.70287414
66Complement and coagulation cascades_Homo sapiens_hsa046100.62918857
67Oocyte meiosis_Homo sapiens_hsa041140.62459287
68Hippo signaling pathway_Homo sapiens_hsa043900.62443870
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60952380
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58906745
71Pentose phosphate pathway_Homo sapiens_hsa000300.58652574
72Propanoate metabolism_Homo sapiens_hsa006400.58436863
73Epstein-Barr virus infection_Homo sapiens_hsa051690.58226358
74Autoimmune thyroid disease_Homo sapiens_hsa053200.58093087
75Phototransduction_Homo sapiens_hsa047440.56951782
76Galactose metabolism_Homo sapiens_hsa000520.56045433
77Fatty acid elongation_Homo sapiens_hsa000620.55154698
78Arginine biosynthesis_Homo sapiens_hsa002200.54345741
79Melanogenesis_Homo sapiens_hsa049160.53091315
80Huntingtons disease_Homo sapiens_hsa050160.51323403
81Thyroid cancer_Homo sapiens_hsa052160.50285985
82Regulation of autophagy_Homo sapiens_hsa041400.50203426
83Arachidonic acid metabolism_Homo sapiens_hsa005900.50188298
842-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48860091
85Systemic lupus erythematosus_Homo sapiens_hsa053220.48134620
86Small cell lung cancer_Homo sapiens_hsa052220.47112279
87Nicotine addiction_Homo sapiens_hsa050330.44782492
88Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44450487
89Intestinal immune network for IgA production_Homo sapiens_hsa046720.44118333
90Arginine and proline metabolism_Homo sapiens_hsa003300.44099759
91Antigen processing and presentation_Homo sapiens_hsa046120.42187444
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40843016
93Metabolic pathways_Homo sapiens_hsa011000.40376474
94Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40367999
95MicroRNAs in cancer_Homo sapiens_hsa052060.39843040
96Biosynthesis of amino acids_Homo sapiens_hsa012300.39747350
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37223213
98Vitamin digestion and absorption_Homo sapiens_hsa049770.37019812
99HTLV-I infection_Homo sapiens_hsa051660.35857400
100Primary immunodeficiency_Homo sapiens_hsa053400.35254743
101Butanoate metabolism_Homo sapiens_hsa006500.34599473
102Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.34462827
103Starch and sucrose metabolism_Homo sapiens_hsa005000.34178635
104Carbon metabolism_Homo sapiens_hsa012000.34007162
105Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31974076
106Pyruvate metabolism_Homo sapiens_hsa006200.30725443
107Tyrosine metabolism_Homo sapiens_hsa003500.29996628
108Fat digestion and absorption_Homo sapiens_hsa049750.29005656
109Insulin secretion_Homo sapiens_hsa049110.28744827
110Nitrogen metabolism_Homo sapiens_hsa009100.26605244
111PPAR signaling pathway_Homo sapiens_hsa033200.26194808
112NF-kappa B signaling pathway_Homo sapiens_hsa040640.25852585
113Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.24874443
114Viral carcinogenesis_Homo sapiens_hsa052030.24302062
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.23940259
116Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.23501096
117Hematopoietic cell lineage_Homo sapiens_hsa046400.23413234
118Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.23164078
119Olfactory transduction_Homo sapiens_hsa047400.23100395
120Measles_Homo sapiens_hsa051620.22453310
121Parkinsons disease_Homo sapiens_hsa050120.22242443
122Fatty acid metabolism_Homo sapiens_hsa012120.18222042
123Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.17447402
124NOD-like receptor signaling pathway_Homo sapiens_hsa046210.16545256
125TGF-beta signaling pathway_Homo sapiens_hsa043500.15971316
126Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.15950027
127Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.15469600
128Morphine addiction_Homo sapiens_hsa050320.13863191
129Vitamin B6 metabolism_Homo sapiens_hsa007500.13006272
130Taste transduction_Homo sapiens_hsa047420.12264702
131Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.11264353

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