HMGN2P41

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)8.24594781
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450917.34682167
3cytidine deamination (GO:0009972)6.75140835
4cytidine metabolic process (GO:0046087)6.75140835
5cytidine catabolic process (GO:0006216)6.75140835
6pyrimidine ribonucleoside catabolic process (GO:0046133)5.84610239
7deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.23902006
8rRNA modification (GO:0000154)4.98972998
9rRNA methylation (GO:0031167)4.79525637
10sequestering of actin monomers (GO:0042989)4.46533312
11positive regulation of interleukin-8 secretion (GO:2000484)4.44124775
12establishment of protein localization to mitochondrial membrane (GO:0090151)4.40331075
13deoxyribonucleoside triphosphate metabolic process (GO:0009200)4.37577422
14mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.29186076
15regulation of cellular amino acid metabolic process (GO:0006521)4.19322149
16negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.02556455
17energy coupled proton transport, down electrochemical gradient (GO:0015985)4.00774644
18ATP synthesis coupled proton transport (GO:0015986)4.00774644
19proteasome assembly (GO:0043248)3.93507027
20deoxyribonucleotide biosynthetic process (GO:0009263)3.92331661
21DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.87215666
22oxidative phosphorylation (GO:0006119)3.83146924
23deoxyribose phosphate biosynthetic process (GO:0046385)3.80201223
242-deoxyribonucleotide biosynthetic process (GO:0009265)3.80201223
25intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.77772256
26signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.77772256
27signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.76964484
28signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.76964484
29signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.76964484
30Arp2/3 complex-mediated actin nucleation (GO:0034314)3.76406295
31negative regulation of ligase activity (GO:0051352)3.67707402
32negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.67707402
33signal transduction involved in DNA integrity checkpoint (GO:0072401)3.66362344
34signal transduction involved in DNA damage checkpoint (GO:0072422)3.66362344
35purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.66199181
36cytolysis (GO:0019835)3.65894557
37signal transduction involved in cell cycle checkpoint (GO:0072395)3.64881627
38positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.64023819
39pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.60392092
40actin nucleation (GO:0045010)3.56834176
41respiratory electron transport chain (GO:0022904)3.56447455
42mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.55801753
43regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.53115521
44regulation of interleukin-8 secretion (GO:2000482)3.52420423
45electron transport chain (GO:0022900)3.50175149
46deoxyribonucleotide metabolic process (GO:0009262)3.47034102
47deoxyribonucleotide catabolic process (GO:0009264)3.45103974
48lipopolysaccharide biosynthetic process (GO:0009103)3.44289981
49antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.43366113
50deoxyribose phosphate metabolic process (GO:0019692)3.42764914
51T cell migration (GO:0072678)3.42515272
52cellular ketone body metabolic process (GO:0046950)3.42085453
53purine-containing compound salvage (GO:0043101)3.41127203
54mismatch repair (GO:0006298)3.39008761
55cellular response to interferon-beta (GO:0035458)3.35039314
56anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.32853867
57tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.30287247
58RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.30287247
59deoxyribose phosphate catabolic process (GO:0046386)3.29329855
60antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.24748032
61negative regulation of receptor activity (GO:2000272)3.22653873
62negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.14211159
63respiratory chain complex IV assembly (GO:0008535)3.12023680
64regulation of cellular amine metabolic process (GO:0033238)3.10594783
65negative T cell selection (GO:0043383)3.10580064
66lipopolysaccharide metabolic process (GO:0008653)3.10153491
67response to interferon-beta (GO:0035456)3.08312101
68positive regulation of cell cycle arrest (GO:0071158)3.04431393
69positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.03591077
70ketone body metabolic process (GO:1902224)3.03239248
71DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.02764034
722-deoxyribonucleotide metabolic process (GO:0009394)3.02502880
73pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.02153426
74nucleobase biosynthetic process (GO:0046112)2.97652787
75telomere maintenance via semi-conservative replication (GO:0032201)2.94047142
76DNA damage response, detection of DNA damage (GO:0042769)2.93975738
77cytochrome complex assembly (GO:0017004)2.90921203
78mannosylation (GO:0097502)2.89970697
79nucleotide-excision repair, DNA gap filling (GO:0006297)2.88375125
80DNA strand elongation involved in DNA replication (GO:0006271)2.86390866
81purine nucleobase biosynthetic process (GO:0009113)2.85868372
82positive regulation of ligase activity (GO:0051351)2.84999279
83DNA strand elongation (GO:0022616)2.79495678
84DNA double-strand break processing (GO:0000729)2.79468624
85cellular response to exogenous dsRNA (GO:0071360)2.77901461
86DNA ligation (GO:0006266)2.77479276
87positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.77111116
88ATP biosynthetic process (GO:0006754)2.75463916
89negative thymic T cell selection (GO:0045060)2.75200537
90telomere maintenance via recombination (GO:0000722)2.73496962
91reciprocal DNA recombination (GO:0035825)2.72856882
92reciprocal meiotic recombination (GO:0007131)2.72856882
93regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.72842079
94positive regulation of natural killer cell mediated immunity (GO:0002717)2.72087902
95positive regulation of alpha-beta T cell proliferation (GO:0046641)2.70850220
96CENP-A containing nucleosome assembly (GO:0034080)2.68541305
97purine nucleotide salvage (GO:0032261)2.67858152
98regulation of cell cycle arrest (GO:0071156)2.66450501
99negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)2.63234342
100negative regulation of cell cycle G1/S phase transition (GO:1902807)2.63234342

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.58341510
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human5.49801175
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.28787997
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.77170597
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.75880939
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.52778408
7IGF1R_20145208_ChIP-Seq_DFB_Human3.23161167
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.17815896
9E2F4_17652178_ChIP-ChIP_JURKAT_Human3.07234657
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.96674873
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.86702385
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.69729281
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.67702210
14VDR_23849224_ChIP-Seq_CD4+_Human2.64572364
15ELK1_19687146_ChIP-ChIP_HELA_Human2.37043441
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.31506038
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.28702027
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.22589867
19PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.21597586
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.18528668
21FOXP3_21729870_ChIP-Seq_TREG_Human2.04575968
22EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.03665966
23SRF_21415370_ChIP-Seq_HL-1_Mouse2.02511113
24IRF8_22096565_ChIP-ChIP_GC-B_Human1.96649980
25IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.94506437
26ZNF274_21170338_ChIP-Seq_K562_Hela1.90162174
27NOTCH1_21737748_ChIP-Seq_TLL_Human1.82139428
28MYC_18358816_ChIP-ChIP_MESCs_Mouse1.77228881
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.75196725
30CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.69853247
31MYC_18555785_ChIP-Seq_MESCs_Mouse1.68014894
32HTT_18923047_ChIP-ChIP_STHdh_Human1.66462064
33FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.63427774
34HOXB4_20404135_ChIP-ChIP_EML_Mouse1.57659423
35YY1_21170310_ChIP-Seq_MESCs_Mouse1.47610475
36PADI4_21655091_ChIP-ChIP_MCF-7_Human1.46348882
37FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45439189
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.44042296
39PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.42499859
40IRF8_21731497_ChIP-ChIP_J774_Mouse1.41643769
41IRF1_19129219_ChIP-ChIP_H3396_Human1.41212880
42MYC_18940864_ChIP-ChIP_HL60_Human1.40929354
43STAT6_21828071_ChIP-Seq_BEAS2B_Human1.36337433
44MYC_19030024_ChIP-ChIP_MESCs_Mouse1.34360598
45POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.32809149
46FLI1_27457419_Chip-Seq_LIVER_Mouse1.29970255
47GABP_19822575_ChIP-Seq_HepG2_Human1.29837455
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.29564186
49E2F1_18555785_ChIP-Seq_MESCs_Mouse1.29030870
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.27841920
51GATA3_26560356_Chip-Seq_TH2_Human1.27817111
52MYB_26560356_Chip-Seq_TH2_Human1.27811621
53THAP11_20581084_ChIP-Seq_MESCs_Mouse1.25134456
54SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.25086331
55RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.24195926
56CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.23102578
57PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.23011118
58CIITA_25753668_ChIP-Seq_RAJI_Human1.22794733
59STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.19858933
60FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.19473453
61FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.18254810
62TTF2_22483619_ChIP-Seq_HELA_Human1.18240502
63EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.16382294
64VDR_22108803_ChIP-Seq_LS180_Human1.13960371
65CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.12566082
66DCP1A_22483619_ChIP-Seq_HELA_Human1.11901687
67NCOR_22424771_ChIP-Seq_293T_Human1.10357403
68STAT4_19710469_ChIP-ChIP_TH1__Mouse1.10099260
69ERG_20517297_ChIP-Seq_VCAP_Human1.05036386
70FOXM1_23109430_ChIP-Seq_U2OS_Human1.04017905
71AR_20517297_ChIP-Seq_VCAP_Human1.03721348
72GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03507604
73TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.02633666
74TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02421211
75BCL6_27268052_Chip-Seq_Bcells_Human1.01482080
76LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.01348806
77YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00565339
78BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99713328
79TP53_22573176_ChIP-Seq_HFKS_Human0.97289431
80CTBP1_25329375_ChIP-Seq_LNCAP_Human0.95652801
81TAF15_26573619_Chip-Seq_HEK293_Human0.95639073
82EWS_26573619_Chip-Seq_HEK293_Human0.94249949
83GATA3_27048872_Chip-Seq_THYMUS_Human0.93398817
84TAF2_19829295_ChIP-Seq_ESCs_Human0.93360197
85RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.91920666
86XRN2_22483619_ChIP-Seq_HELA_Human0.91103038
87MYC_19829295_ChIP-Seq_ESCs_Human0.90593317
88FOXA1_25329375_ChIP-Seq_VCAP_Human0.90082278
89FOXA1_27270436_Chip-Seq_PROSTATE_Human0.90082278
90ERA_21632823_ChIP-Seq_H3396_Human0.89951854
91CTBP2_25329375_ChIP-Seq_LNCAP_Human0.89372304
92PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88585528
93NELFA_20434984_ChIP-Seq_ESCs_Mouse0.88014049
94TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.87665657
95AUTS2_25519132_ChIP-Seq_293T-REX_Human0.86437578
96EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.86239353
97E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.84958518
98RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.84617330
99FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84035530
100FOXH1_21741376_ChIP-Seq_EPCs_Human0.83629253

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.12577417
2MP0005083_abnormal_biliary_tract2.84900991
3MP0003693_abnormal_embryo_hatching2.83928432
4MP0008877_abnormal_DNA_methylation2.69080059
5MP0002006_tumorigenesis2.66291098
6MP0010094_abnormal_chromosome_stability2.66035010
7MP0004145_abnormal_muscle_electrophysio2.61911178
8MP0002166_altered_tumor_susceptibility2.59704236
9MP0001986_abnormal_taste_sensitivity2.47068473
10MP0009785_altered_susceptibility_to2.47055335
11MP0005084_abnormal_gallbladder_morpholo2.37454034
12MP0006036_abnormal_mitochondrial_physio2.35358906
13MP0001835_abnormal_antigen_presentation2.33899534
14MP0006082_CNS_inflammation2.30010969
15MP0003195_calcinosis2.16176203
16MP0006072_abnormal_retinal_apoptosis2.11599869
17MP0004147_increased_porphyrin_level2.07088039
18MP0003787_abnormal_imprinting2.05521013
19MP0004957_abnormal_blastocyst_morpholog2.02779347
20MP0008058_abnormal_DNA_repair1.93360271
21MP0003866_abnormal_defecation1.92009902
22MP0009333_abnormal_splenocyte_physiolog1.85743302
23MP0003045_fibrosis1.82424408
24MP0003786_premature_aging1.76631316
25MP0005025_abnormal_response_to1.72030062
26MP0003763_abnormal_thymus_physiology1.67726022
27MP0005000_abnormal_immune_tolerance1.58481251
28MP0001661_extended_life_span1.56716714
29MP0000372_irregular_coat_pigmentation1.50063437
30MP0003111_abnormal_nucleus_morphology1.46919871
31MP0003448_altered_tumor_morphology1.40233288
32MP0005645_abnormal_hypothalamus_physiol1.38975976
33MP0001919_abnormal_reproductive_system1.38254521
34MP0002420_abnormal_adaptive_immunity1.33744855
35MP0008872_abnormal_physiological_respon1.29791175
36MP0005360_urolithiasis1.29701731
37MP0001800_abnormal_humoral_immune1.29071790
38MP0005636_abnormal_mineral_homeostasis1.27119369
39MP0001819_abnormal_immune_cell1.27013246
40MP0003718_maternal_effect1.26187694
41MP0005387_immune_system_phenotype1.24563892
42MP0001790_abnormal_immune_system1.24563892
43MP0003137_abnormal_impulse_conducting1.24207374
44MP0005551_abnormal_eye_electrophysiolog1.22654478
45MP0005253_abnormal_eye_physiology1.22503472
46MP0005389_reproductive_system_phenotype1.19457704
47MP0006276_abnormal_autonomic_nervous1.19140652
48MP0005584_abnormal_enzyme/coenzyme_acti1.17396588
49MP0002148_abnormal_hypersensitivity_rea1.15690912
50MP0000685_abnormal_immune_system1.15334106
51MP0002723_abnormal_immune_serum1.14368547
52MP0004133_heterotaxia1.14059697
53MP0001968_abnormal_touch/_nociception1.12195291
54MP0003724_increased_susceptibility_to1.11798216
55MP0005167_abnormal_blood-brain_barrier1.10725641
56MP0001764_abnormal_homeostasis1.10656575
57MP0001929_abnormal_gametogenesis1.10010993
58MP0001542_abnormal_bone_strength1.08417946
59MP0003283_abnormal_digestive_organ1.08042098
60MP0002452_abnormal_antigen_presenting1.07653635
61MP0002160_abnormal_reproductive_system1.04482050
62MP0008875_abnormal_xenobiotic_pharmacok1.02546842
63MP0003646_muscle_fatigue1.01219196
64MP0000716_abnormal_immune_system1.01091164
65MP0000689_abnormal_spleen_morphology1.00434764
66MP0002693_abnormal_pancreas_physiology0.99787066
67MP0001905_abnormal_dopamine_level0.99158341
68MP0002398_abnormal_bone_marrow0.99012017
69MP0006035_abnormal_mitochondrial_morpho0.98152064
70MP0008007_abnormal_cellular_replicative0.96552846
71MP0002102_abnormal_ear_morphology0.95756608
72MP0000703_abnormal_thymus_morphology0.93993124
73MP0001119_abnormal_female_reproductive0.93938679
74MP0004215_abnormal_myocardial_fiber0.93805662
75MP0002722_abnormal_immune_system0.89924511
76MP0002210_abnormal_sex_determination0.89816972
77MP0001845_abnormal_inflammatory_respons0.88652986
78MP0010386_abnormal_urinary_bladder0.88639837
79MP0005379_endocrine/exocrine_gland_phen0.87674007
80MP0002019_abnormal_tumor_incidence0.87488594
81MP0005310_abnormal_salivary_gland0.84607363
82MP0005377_hearing/vestibular/ear_phenot0.84484456
83MP0003878_abnormal_ear_physiology0.84484456
84MP0009046_muscle_twitch0.83532897
85MP0003121_genomic_imprinting0.82476434
86MP0009643_abnormal_urine_homeostasis0.82440029
87MP0002272_abnormal_nervous_system0.82384236
88MP0008932_abnormal_embryonic_tissue0.82378696
89MP0002736_abnormal_nociception_after0.81352299
90MP0009745_abnormal_behavioral_response0.81309923
91MP0009763_increased_sensitivity_to0.80717658
92MP0002163_abnormal_gland_morphology0.79647387
93MP0003077_abnormal_cell_cycle0.77062348
94MP0002429_abnormal_blood_cell0.76448444
95MP0000653_abnormal_sex_gland0.74405419
96MP0002876_abnormal_thyroid_physiology0.74349275
97MP0005332_abnormal_amino_acid0.74153124
98MP0005395_other_phenotype0.73466680
99MP0002733_abnormal_thermal_nociception0.72315788
100MP0010329_abnormal_lipoprotein_level0.71433306

Predicted human phenotypes

RankGene SetZ-score
1Hepatocellular necrosis (HP:0001404)5.07995415
2Hepatic necrosis (HP:0002605)4.87841427
3Hypoproteinemia (HP:0003075)4.32208981
4Severe combined immunodeficiency (HP:0004430)4.12600187
5Mitochondrial inheritance (HP:0001427)4.12041121
6Increased CSF lactate (HP:0002490)3.62606272
7Acute necrotizing encephalopathy (HP:0006965)3.56707730
83-Methylglutaconic aciduria (HP:0003535)3.56144309
9Generalized aminoaciduria (HP:0002909)3.34360610
10Combined immunodeficiency (HP:0005387)3.32151902
11Abnormal mitochondria in muscle tissue (HP:0008316)3.30095242
12Elevated erythrocyte sedimentation rate (HP:0003565)3.19109872
13Aplastic anemia (HP:0001915)3.18452996
14Colon cancer (HP:0003003)3.06535151
15Thyroiditis (HP:0100646)3.05564850
16Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.03286740
17Acute encephalopathy (HP:0006846)2.98180220
18Type I transferrin isoform profile (HP:0003642)2.96895594
19Progressive macrocephaly (HP:0004481)2.94972913
20Abnormality of T cell number (HP:0011839)2.93814974
21IgG deficiency (HP:0004315)2.93154463
22Increased hepatocellular lipid droplets (HP:0006565)2.90573741
23Pancreatic cysts (HP:0001737)2.90170386
24T lymphocytopenia (HP:0005403)2.88384356
25Aplasia/Hypoplasia of the uvula (HP:0010293)2.85089646
26Increased IgM level (HP:0003496)2.84570093
27Abnormality of B cell number (HP:0010975)2.76996082
28Decreased electroretinogram (ERG) amplitude (HP:0000654)2.76453967
29Lactic acidosis (HP:0003128)2.72379899
30Molar tooth sign on MRI (HP:0002419)2.71451112
31Abnormality of midbrain morphology (HP:0002418)2.71451112
32Hypothermia (HP:0002045)2.68966101
33Abnormality of eosinophils (HP:0001879)2.66936328
34True hermaphroditism (HP:0010459)2.62248605
35Autoimmune hemolytic anemia (HP:0001890)2.61681085
36Autoimmune thrombocytopenia (HP:0001973)2.60768844
37B lymphocytopenia (HP:0010976)2.58025479
38Renal Fanconi syndrome (HP:0001994)2.56225163
39Pancreatic fibrosis (HP:0100732)2.52124320
40Lipid accumulation in hepatocytes (HP:0006561)2.51927264
41Abnormal albumin level (HP:0012116)2.51007546
42Hypoalbuminemia (HP:0003073)2.51007546
43Abnormality of the labia minora (HP:0012880)2.48560456
44Cerebral edema (HP:0002181)2.46466962
45Increased serum lactate (HP:0002151)2.46325075
46Eosinophilia (HP:0001880)2.44889471
47Respiratory failure (HP:0002878)2.44171794
48Dicarboxylic aciduria (HP:0003215)2.43930235
49Abnormality of dicarboxylic acid metabolism (HP:0010995)2.43930235
50Decreased activity of mitochondrial respiratory chain (HP:0008972)2.41098151
51Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.41098151
52Increased intramyocellular lipid droplets (HP:0012240)2.39861343
53CNS demyelination (HP:0007305)2.37563680
54Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.34557333
55Pancytopenia (HP:0001876)2.34274384
56Neoplasm of the adrenal gland (HP:0100631)2.33053851
57Abnormality of the prostate (HP:0008775)2.32370355
58Meckel diverticulum (HP:0002245)2.32026675
59Attenuation of retinal blood vessels (HP:0007843)2.30059129
60Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.29806200
61Abnormal protein N-linked glycosylation (HP:0012347)2.29806200
62Abnormal protein glycosylation (HP:0012346)2.29806200
63Abnormal glycosylation (HP:0012345)2.29806200
64Clubbing of toes (HP:0100760)2.29791308
65Amyotrophic lateral sclerosis (HP:0007354)2.29247599
66Abnormality of the ileum (HP:0001549)2.28290627
67Absent rod-and cone-mediated responses on ERG (HP:0007688)2.26900796
68Renal cortical cysts (HP:0000803)2.26026529
69Chronic diarrhea (HP:0002028)2.25298298
70Hemiplegia (HP:0002301)2.25088550
71Encephalitis (HP:0002383)2.22681383
72Constricted visual fields (HP:0001133)2.19825283
73Nephronophthisis (HP:0000090)2.15249837
74Petechiae (HP:0000967)2.12870002
75Optic disc pallor (HP:0000543)2.11116869
76Reduced antithrombin III activity (HP:0001976)2.07103040
77Exertional dyspnea (HP:0002875)2.06715781
78Abnormality of T cells (HP:0002843)2.06081405
79Atrophy/Degeneration involving motor neurons (HP:0007373)2.05801103
80Short tibia (HP:0005736)1.99946965
81Hypoplasia of the pons (HP:0012110)1.98903996
82Microretrognathia (HP:0000308)1.96494276
83Tinnitus (HP:0000360)1.95809109
84Congenital stationary night blindness (HP:0007642)1.95440542
85Ketosis (HP:0001946)1.90701062
86Abnormality of the pons (HP:0007361)1.90517625
87Acute hepatic failure (HP:0006554)1.89851546
88Increased muscle lipid content (HP:0009058)1.84341356
89Cerebral palsy (HP:0100021)1.83836381
90Panhypogammaglobulinemia (HP:0003139)1.83313528
91Mesangial abnormality (HP:0001966)1.78621531
92Sclerocornea (HP:0000647)1.78461423
93Aplasia/Hypoplasia of the tibia (HP:0005772)1.78052703
94Abnormality of chromosome stability (HP:0003220)1.77283079
95Lymphoma (HP:0002665)1.76820605
96Neuroendocrine neoplasm (HP:0100634)1.76229098
97Emotional lability (HP:0000712)1.75179926
98Abnormality of the preputium (HP:0100587)1.72535527
99Patellar aplasia (HP:0006443)1.72010014
100Type II lissencephaly (HP:0007260)1.71645310

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR4.81195306
2TESK24.65588027
3VRK24.23765056
4ZAK2.83431538
5VRK12.67005251
6NUAK12.65570334
7TXK2.62152217
8BUB12.59515631
9BCKDK2.33191992
10CSNK1G32.24329922
11TLK12.16456791
12TAF12.15065885
13TAOK32.03991212
14CSNK1A1L2.01133384
15TESK11.89802050
16STK161.87379808
17PLK41.80249581
18BCR1.77019770
19LIMK11.75363478
20CSNK1G11.73071305
21NEK11.70122385
22CSNK1G21.65140378
23ITK1.58230654
24MST41.52995130
25TEC1.50979643
26CDC71.42330817
27SRPK11.28240861
28GRK11.20590606
29NME11.16432318
30MAP2K71.15684419
31ERBB31.14080819
32PLK31.11384193
33FRK1.08403374
34WEE11.06706544
35GRK51.05724996
36NEK91.03844847
37SMG11.03563750
38EIF2AK30.98122277
39ADRBK20.96662286
40MAPKAPK50.96332545
41DYRK20.95548205
42AURKA0.93368771
43TIE10.92744933
44CDK190.90066014
45DAPK10.87078493
46EIF2AK10.80674603
47TRIM280.80232658
48AURKB0.79860460
49EIF2AK20.78369451
50WNK30.76579384
51MAPK130.74942951
52ATR0.73857444
53SYK0.71276211
54MKNK10.69927279
55PLK10.67671409
56PRKCQ0.66461051
57WNK40.65029081
58MAP4K10.60120974
59BTK0.59593144
60RPS6KA40.59186021
61IRAK10.58008759
62MAPKAPK30.56576121
63BRSK20.54556405
64SIK20.53783392
65NTRK30.53735496
66LCK0.52431553
67CDK140.49541454
68CHEK20.49299813
69TNK20.49277626
70ZAP700.48422707
71MAP4K20.48363833
72RPS6KA50.46489346
73RAF10.45745058
74INSRR0.44795899
75LYN0.43571393
76CSNK1A10.42736101
77BRSK10.42617294
78CSNK2A10.41941130
79CDK11A0.41821388
80IRAK40.39902474
81CDK180.39180368
82PHKG20.38916990
83PHKG10.38916990
84TSSK60.38168922
85OXSR10.38047817
86CDK150.37898262
87MINK10.37375344
88CSK0.34622855
89STK390.34042130
90PAK10.33360765
91CCNB10.31137695
92PAK30.28384920
93PDK20.27944745
94PLK20.27504589
95PIK3CG0.26221926
96MAP2K60.25171903
97FYN0.24769940
98PRKACA0.24279841
99CAMKK20.23867193
100TRPM70.23282950

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.23326175
2Primary immunodeficiency_Homo sapiens_hsa053403.43695161
3Oxidative phosphorylation_Homo sapiens_hsa001903.30460876
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.19316367
5DNA replication_Homo sapiens_hsa030303.07508605
6Parkinsons disease_Homo sapiens_hsa050122.91379121
7Mismatch repair_Homo sapiens_hsa034302.71786110
8Homologous recombination_Homo sapiens_hsa034402.60069693
9Sulfur metabolism_Homo sapiens_hsa009202.39928131
10Fanconi anemia pathway_Homo sapiens_hsa034602.31278396
11Protein export_Homo sapiens_hsa030602.20495696
12Base excision repair_Homo sapiens_hsa034102.09800400
13Non-homologous end-joining_Homo sapiens_hsa034502.02044807
14Autoimmune thyroid disease_Homo sapiens_hsa053201.94478632
15RNA polymerase_Homo sapiens_hsa030201.94192493
16Huntingtons disease_Homo sapiens_hsa050161.90309775
17Graft-versus-host disease_Homo sapiens_hsa053321.89170403
18Propanoate metabolism_Homo sapiens_hsa006401.80755837
19Alzheimers disease_Homo sapiens_hsa050101.78820916
20Allograft rejection_Homo sapiens_hsa053301.77279349
21Butanoate metabolism_Homo sapiens_hsa006501.74715963
22Spliceosome_Homo sapiens_hsa030401.58819388
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.53711493
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.53500807
25Type I diabetes mellitus_Homo sapiens_hsa049401.52604508
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.51871066
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.50236838
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.49761985
29One carbon pool by folate_Homo sapiens_hsa006701.41516496
30Fatty acid elongation_Homo sapiens_hsa000621.39971058
31Antigen processing and presentation_Homo sapiens_hsa046121.39293683
32Nucleotide excision repair_Homo sapiens_hsa034201.36003187
33Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.35212008
34Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.31902918
35Pyrimidine metabolism_Homo sapiens_hsa002401.31240619
36Steroid biosynthesis_Homo sapiens_hsa001001.28041980
37Cardiac muscle contraction_Homo sapiens_hsa042601.21730837
38Ribosome_Homo sapiens_hsa030101.20227043
39Hematopoietic cell lineage_Homo sapiens_hsa046401.02774035
40Fatty acid metabolism_Homo sapiens_hsa012121.01342321
41Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.00300821
42Purine metabolism_Homo sapiens_hsa002300.98746319
43Fatty acid degradation_Homo sapiens_hsa000710.93290559
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.92872144
45Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92855252
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.90173964
47Phototransduction_Homo sapiens_hsa047440.90171150
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.89706424
49Peroxisome_Homo sapiens_hsa041460.88887400
50Intestinal immune network for IgA production_Homo sapiens_hsa046720.83622215
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.75478468
52Nitrogen metabolism_Homo sapiens_hsa009100.75327976
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75323582
54RNA degradation_Homo sapiens_hsa030180.73167958
55T cell receptor signaling pathway_Homo sapiens_hsa046600.72026326
56RNA transport_Homo sapiens_hsa030130.68426582
57Asthma_Homo sapiens_hsa053100.67419950
58Glutathione metabolism_Homo sapiens_hsa004800.64302120
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61199870
60Shigellosis_Homo sapiens_hsa051310.58609780
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56206765
62Basal transcription factors_Homo sapiens_hsa030220.55354103
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55223540
64Tryptophan metabolism_Homo sapiens_hsa003800.55117136
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.53734817
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53710259
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53172809
68Carbon metabolism_Homo sapiens_hsa012000.51969649
69Viral myocarditis_Homo sapiens_hsa054160.49955265
70Metabolic pathways_Homo sapiens_hsa011000.49043004
71Systemic lupus erythematosus_Homo sapiens_hsa053220.47061566
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.47011558
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.45063822
74Cell cycle_Homo sapiens_hsa041100.44973782
75Folate biosynthesis_Homo sapiens_hsa007900.44022144
76Rheumatoid arthritis_Homo sapiens_hsa053230.43729458
77Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.42995280
78Pyruvate metabolism_Homo sapiens_hsa006200.42127015
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41061433
80Olfactory transduction_Homo sapiens_hsa047400.39550394
81Linoleic acid metabolism_Homo sapiens_hsa005910.33145232
82Pentose phosphate pathway_Homo sapiens_hsa000300.31827341
83Biosynthesis of amino acids_Homo sapiens_hsa012300.30746357
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30342491
85beta-Alanine metabolism_Homo sapiens_hsa004100.30228576
86Measles_Homo sapiens_hsa051620.29917035
87Herpes simplex infection_Homo sapiens_hsa051680.29549374
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.27463374
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.27438542
90mRNA surveillance pathway_Homo sapiens_hsa030150.25782738
91Salmonella infection_Homo sapiens_hsa051320.25415709
92Phenylalanine metabolism_Homo sapiens_hsa003600.24115187
93Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.23047514
94Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.22924660
95Taste transduction_Homo sapiens_hsa047420.21974290
96Mineral absorption_Homo sapiens_hsa049780.21607687
97Oocyte meiosis_Homo sapiens_hsa041140.19232035
98Epstein-Barr virus infection_Homo sapiens_hsa051690.17815540
99Selenocompound metabolism_Homo sapiens_hsa004500.17013857
100Alcoholism_Homo sapiens_hsa050340.16557207

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