HMGN2P31

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450918.78746124
2DNA deamination (GO:0045006)8.57191031
3cytidine deamination (GO:0009972)8.38805488
4cytidine metabolic process (GO:0046087)8.38805488
5cytidine catabolic process (GO:0006216)8.38805488
6pyrimidine ribonucleoside catabolic process (GO:0046133)7.28751945
7Arp2/3 complex-mediated actin nucleation (GO:0034314)6.10687385
8actin nucleation (GO:0045010)5.40030828
9deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.37183665
10sequestering of actin monomers (GO:0042989)5.17833874
11deoxyribonucleoside triphosphate metabolic process (GO:0009200)5.03308136
12regulation of B cell receptor signaling pathway (GO:0050855)4.74727535
13macrophage chemotaxis (GO:0048246)4.68029967
14purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)4.54713312
15cytolysis (GO:0019835)4.46245455
16negative regulation of T cell apoptotic process (GO:0070233)4.45428412
17positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.44188728
18positive regulation of natural killer cell mediated immunity (GO:0002717)4.30684925
19deoxyribose phosphate biosynthetic process (GO:0046385)4.30600859
202-deoxyribonucleotide biosynthetic process (GO:0009265)4.30600859
21positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.29220344
22negative regulation by host of viral transcription (GO:0043922)4.15360294
23deoxyribonucleotide biosynthetic process (GO:0009263)4.14550982
24mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.07375280
25eosinophil chemotaxis (GO:0048245)3.95214451
26negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.91091051
27negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.77000755
28DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.76644288
29regulation of cellular amino acid metabolic process (GO:0006521)3.74097204
30respiratory electron transport chain (GO:0022904)3.72124041
31energy coupled proton transport, down electrochemical gradient (GO:0015985)3.70144303
32ATP synthesis coupled proton transport (GO:0015986)3.70144303
33regulation of activation of Janus kinase activity (GO:0010533)3.68611055
34regulation of T cell receptor signaling pathway (GO:0050856)3.68124639
35signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.66352585
36intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.66352585
37electron transport chain (GO:0022900)3.65230167
38purine deoxyribonucleotide metabolic process (GO:0009151)3.64865913
39signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.63274123
40signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.63274123
41signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.63274123
42mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.61761226
43purine deoxyribonucleotide catabolic process (GO:0009155)3.59077524
44negative regulation of viral genome replication (GO:0045071)3.58880417
45eosinophil migration (GO:0072677)3.57847509
46positive regulation of T cell apoptotic process (GO:0070234)3.56520296
47regulation of natural killer cell mediated immunity (GO:0002715)3.56308399
48regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.56308399
49regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.54328033
50antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.48925456
51pyrimidine nucleoside catabolic process (GO:0046135)3.47453838
52signal transduction involved in DNA damage checkpoint (GO:0072422)3.44401128
53signal transduction involved in DNA integrity checkpoint (GO:0072401)3.44401128
54deoxyribonucleoside diphosphate metabolic process (GO:0009186)3.44211722
55negative regulation of T cell receptor signaling pathway (GO:0050860)3.43854396
56negative regulation of oxidoreductase activity (GO:0051354)3.43737150
57positive regulation of lamellipodium assembly (GO:0010592)3.43007146
58positive regulation of translational initiation (GO:0045948)3.41731161
59signal transduction involved in cell cycle checkpoint (GO:0072395)3.40622227
60positive T cell selection (GO:0043368)3.40585435
61negative regulation of ligase activity (GO:0051352)3.36845830
62negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.36845830
63positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.34203401
64negative regulation of execution phase of apoptosis (GO:1900118)3.30367828
65cellular response to interleukin-15 (GO:0071350)3.29422360
66negative regulation of lymphocyte apoptotic process (GO:0070229)3.28405768
67antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.26159147
68regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.25496759
69positive regulation of calcium-mediated signaling (GO:0050850)3.24285326
702-deoxyribonucleotide metabolic process (GO:0009394)3.23136196
71positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.22448060
72regulation of T cell apoptotic process (GO:0070232)3.17799370
73regulation of chronic inflammatory response (GO:0002676)3.12511032
74positive regulation of interleukin-8 secretion (GO:2000484)3.09755427
75T cell migration (GO:0072678)3.09300373
76deoxyribonucleotide catabolic process (GO:0009264)3.09241900
77deoxyribonucleotide metabolic process (GO:0009262)3.08826692
78deoxyribose phosphate metabolic process (GO:0019692)3.08303780
79positive regulation of cell cycle arrest (GO:0071158)3.07466135
80negative T cell selection (GO:0043383)3.07307066
81anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.04941316
82rRNA modification (GO:0000154)3.03166688
83deoxyribose phosphate catabolic process (GO:0046386)2.98876966
84cellular response to interferon-beta (GO:0035458)2.95159602
85signal peptide processing (GO:0006465)2.93348846
86positive regulation of uterine smooth muscle contraction (GO:0070474)2.93181297
87positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.93172998
88purine nucleotide salvage (GO:0032261)2.92040509
89positive thymic T cell selection (GO:0045059)2.91937125
90response to interferon-beta (GO:0035456)2.90099222
91ubiquinone biosynthetic process (GO:0006744)2.87596089
92positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.86314199
93protein maturation by protein folding (GO:0022417)2.84635327
94pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.82562142
95rRNA methylation (GO:0031167)2.81845328
96positive regulation of cell killing (GO:0031343)2.80359040
97positive regulation of defense response to virus by host (GO:0002230)2.80024015
98regulation of leukocyte mediated cytotoxicity (GO:0001910)2.79785288
99DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.77082450
100positive regulation of ligase activity (GO:0051351)2.75794929

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.75133680
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.01834637
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.81047792
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.09238702
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.69137562
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.59672961
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.47215437
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.34982510
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.85154548
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.79200089
11IGF1R_20145208_ChIP-Seq_DFB_Human2.71339261
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.60306722
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.58802598
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.49914152
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.46754324
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.41993896
17MYB_26560356_Chip-Seq_TH2_Human2.31473173
18VDR_23849224_ChIP-Seq_CD4+_Human2.19788457
19VDR_22108803_ChIP-Seq_LS180_Human2.17330480
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.05627861
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.99832462
22FOXP3_21729870_ChIP-Seq_TREG_Human1.96905373
23FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.94652450
24E2F4_17652178_ChIP-ChIP_JURKAT_Human1.91074176
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.83013547
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.79438929
27SRF_21415370_ChIP-Seq_HL-1_Mouse1.79195224
28LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.73262381
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.72371995
30ETS1_20019798_ChIP-Seq_JURKAT_Human1.69611558
31STAT4_19710469_ChIP-ChIP_TH1__Mouse1.69129372
32GATA3_27048872_Chip-Seq_THYMUS_Human1.65653843
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.65268328
34CREB1_15753290_ChIP-ChIP_HEK293T_Human1.60209469
35HTT_18923047_ChIP-ChIP_STHdh_Human1.57777652
36SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.57654614
37GATA3_26560356_Chip-Seq_TH2_Human1.55125467
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.54425816
39PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.46363907
40CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.44623155
41ELK1_19687146_ChIP-ChIP_HELA_Human1.42269994
42CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.41795059
43NOTCH1_21737748_ChIP-Seq_TLL_Human1.41711677
44RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.39636531
45ERG_20517297_ChIP-Seq_VCAP_Human1.37879357
46FLI1_27457419_Chip-Seq_LIVER_Mouse1.37580142
47RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32403917
48MYB_26560356_Chip-Seq_TH1_Human1.31499749
49MYC_18940864_ChIP-ChIP_HL60_Human1.31000602
50FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.30516658
51PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.28927583
52TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.28295030
53MYC_18358816_ChIP-ChIP_MESCs_Mouse1.28212224
54STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.24742249
55EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.19628127
56SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.19547741
57HOXB4_20404135_ChIP-ChIP_EML_Mouse1.17925983
58PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.17656737
59CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.16530055
60ER_23166858_ChIP-Seq_MCF-7_Human1.16139730
61TAF2_19829295_ChIP-Seq_ESCs_Human1.15620774
62BCL6_27268052_Chip-Seq_Bcells_Human1.15153238
63ELF1_20517297_ChIP-Seq_JURKAT_Human1.14659450
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14021533
65RUNX_20019798_ChIP-Seq_JUKART_Human1.12580916
66ZNF274_21170338_ChIP-Seq_K562_Hela1.11403240
67UTX_26944678_Chip-Seq_JUKART_Human1.10936169
68TP53_22573176_ChIP-Seq_HFKS_Human1.09185689
69ETV2_25802403_ChIP-Seq_MESCs_Mouse1.07218155
70PCGF2_27294783_Chip-Seq_ESCs_Mouse1.07148363
71MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.05484197
72AR_20517297_ChIP-Seq_VCAP_Human1.00572517
73AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00072786
74FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97539848
75FOXA1_25329375_ChIP-Seq_VCAP_Human0.97539848
76DCP1A_22483619_ChIP-Seq_HELA_Human0.97204171
77LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.95517309
78CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.95176966
79POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94865835
80HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.93408191
81P300_27268052_Chip-Seq_Bcells_Human0.93216353
82NCOR_22424771_ChIP-Seq_293T_Human0.93168643
83PCGF2_27294783_Chip-Seq_NPCs_Mouse0.93114599
84GABP_19822575_ChIP-Seq_HepG2_Human0.92819543
85NANOG_19829295_ChIP-Seq_ESCs_Human0.91177661
86SOX2_19829295_ChIP-Seq_ESCs_Human0.91177661
87GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.90920003
88YY1_21170310_ChIP-Seq_MESCs_Mouse0.90282139
89CTBP2_25329375_ChIP-Seq_LNCAP_Human0.89435183
90MAF_26560356_Chip-Seq_TH2_Human0.89091422
91GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.88945576
92P53_21459846_ChIP-Seq_SAOS-2_Human0.88938236
93MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.87302311
94ELK1_22589737_ChIP-Seq_MCF10A_Human0.86989375
95CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86633116
96EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.86577536
97GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.86500248
98NANOG_20526341_ChIP-Seq_ESCs_Human0.86484235
99HOXB7_26014856_ChIP-Seq_BT474_Human0.85100539
100FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84810978

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.57589804
2MP0009785_altered_susceptibility_to3.58455649
3MP0009333_abnormal_splenocyte_physiolog3.29723572
4MP0003763_abnormal_thymus_physiology3.13868968
5MP0002166_altered_tumor_susceptibility2.76761767
6MP0003806_abnormal_nucleotide_metabolis2.71994106
7MP0006082_CNS_inflammation2.69547179
8MP0005451_abnormal_body_composition2.68538134
9MP0001835_abnormal_antigen_presentation2.56391917
10MP0005000_abnormal_immune_tolerance2.42836787
11MP0002653_abnormal_ependyma_morphology2.39049068
12MP0002006_tumorigenesis2.38221938
13MP0005379_endocrine/exocrine_gland_phen2.18351590
14MP0001790_abnormal_immune_system2.16776880
15MP0005387_immune_system_phenotype2.16776880
16MP0001800_abnormal_humoral_immune2.13957924
17MP0005025_abnormal_response_to2.07674362
18MP0002420_abnormal_adaptive_immunity2.03684292
19MP0001819_abnormal_immune_cell1.95912415
20MP0002723_abnormal_immune_serum1.92330763
21MP0001873_stomach_inflammation1.89111707
22MP0002163_abnormal_gland_morphology1.85202493
23MP0002148_abnormal_hypersensitivity_rea1.81834478
24MP0003252_abnormal_bile_duct1.81182030
25MP0003283_abnormal_digestive_organ1.78920175
26MP0009697_abnormal_copulation1.77401990
27MP0000685_abnormal_immune_system1.75124376
28MP0004147_increased_porphyrin_level1.74975874
29MP0010386_abnormal_urinary_bladder1.74437039
30MP0003786_premature_aging1.70792049
31MP0003448_altered_tumor_morphology1.69644527
32MP0002452_abnormal_antigen_presenting1.68005820
33MP0003866_abnormal_defecation1.66803690
34MP0002405_respiratory_system_inflammati1.64638387
35MP0001485_abnormal_pinna_reflex1.62044346
36MP0002933_joint_inflammation1.54524963
37MP0002876_abnormal_thyroid_physiology1.54412113
38MP0005084_abnormal_gallbladder_morpholo1.51815723
39MP0006036_abnormal_mitochondrial_physio1.45875725
40MP0000716_abnormal_immune_system1.45523509
41MP0001845_abnormal_inflammatory_respons1.44145738
42MP0002398_abnormal_bone_marrow1.43993727
43MP0005645_abnormal_hypothalamus_physiol1.43791852
44MP0002160_abnormal_reproductive_system1.39933062
45MP0002234_abnormal_pharynx_morphology1.39541469
46MP0005551_abnormal_eye_electrophysiolog1.38417940
47MP0004145_abnormal_muscle_electrophysio1.36384745
48MP0000689_abnormal_spleen_morphology1.34666570
49MP0002736_abnormal_nociception_after1.34404704
50MP0006072_abnormal_retinal_apoptosis1.33091003
51MP0000703_abnormal_thymus_morphology1.30903215
52MP0002722_abnormal_immune_system1.30195644
53MP0001968_abnormal_touch/_nociception1.27503935
54MP0005389_reproductive_system_phenotype1.21244823
55MP0010094_abnormal_chromosome_stability1.17746820
56MP0002429_abnormal_blood_cell1.17018963
57MP0006035_abnormal_mitochondrial_morpho1.15801719
58MP0002419_abnormal_innate_immunity1.14122581
59MP0001919_abnormal_reproductive_system1.13627196
60MP0001905_abnormal_dopamine_level1.09539226
61MP0002837_dystrophic_cardiac_calcinosis1.09411836
62MP0008875_abnormal_xenobiotic_pharmacok1.08585480
63MP0001661_extended_life_span1.08540559
64MP0004957_abnormal_blastocyst_morpholog1.08353973
65MP0000372_irregular_coat_pigmentation1.05268684
66MP0002693_abnormal_pancreas_physiology1.01892268
67MP0005075_abnormal_melanosome_morpholog1.00710569
68MP0001501_abnormal_sleep_pattern0.99604291
69MP0003567_abnormal_fetal_cardiomyocyte0.92970240
70MP0003045_fibrosis0.91493032
71MP0003436_decreased_susceptibility_to0.91264213
72MP0010155_abnormal_intestine_physiology0.90168530
73MP0005083_abnormal_biliary_tract0.89986634
74MP0003137_abnormal_impulse_conducting0.89378916
75MP0008469_abnormal_protein_level0.88513708
76MP0005377_hearing/vestibular/ear_phenot0.87317775
77MP0003878_abnormal_ear_physiology0.87317775
78MP0008260_abnormal_autophagy0.86388524
79MP0001666_abnormal_nutrient_absorption0.82205408
80MP0001188_hyperpigmentation0.80791478
81MP0006292_abnormal_olfactory_placode0.79581843
82MP0005360_urolithiasis0.76776177
83MP0008872_abnormal_physiological_respon0.76187670
84MP0005464_abnormal_platelet_physiology0.75022814
85MP0009763_increased_sensitivity_to0.74888352
86MP0002019_abnormal_tumor_incidence0.74126954
87MP0001986_abnormal_taste_sensitivity0.72795212
88MP0002909_abnormal_adrenal_gland0.72668170
89MP0005636_abnormal_mineral_homeostasis0.71567925
90MP0003646_muscle_fatigue0.70188191
91MP0000639_abnormal_adrenal_gland0.69050898
92MP0008058_abnormal_DNA_repair0.68593511
93MP0004947_skin_inflammation0.67016174
94MP0004742_abnormal_vestibular_system0.66095493
95MP0002102_abnormal_ear_morphology0.65588813
96MP0000678_abnormal_parathyroid_gland0.62884002
97MP0009643_abnormal_urine_homeostasis0.61706030
98MP0008932_abnormal_embryonic_tissue0.60645049
99MP0001853_heart_inflammation0.58674199
100MP0002136_abnormal_kidney_physiology0.58192290

Predicted human phenotypes

RankGene SetZ-score
1B lymphocytopenia (HP:0010976)5.80824794
2Increased IgM level (HP:0003496)5.39841579
3Abnormality of B cell number (HP:0010975)5.27603989
4T lymphocytopenia (HP:0005403)5.20947788
5Aplastic anemia (HP:0001915)5.02134049
6Severe combined immunodeficiency (HP:0004430)5.02052007
7Abnormality of T cell number (HP:0011839)4.80108028
8Elevated erythrocyte sedimentation rate (HP:0003565)4.51519890
9Combined immunodeficiency (HP:0005387)4.28134622
10IgG deficiency (HP:0004315)4.22391402
11Autoimmune hemolytic anemia (HP:0001890)3.98734757
12Thyroiditis (HP:0100646)3.89318681
13Hepatocellular necrosis (HP:0001404)3.84521245
14Mitochondrial inheritance (HP:0001427)3.81204159
15Hepatic necrosis (HP:0002605)3.77130820
16Autoimmune thrombocytopenia (HP:0001973)3.63319809
17Acute hepatic failure (HP:0006554)3.60916333
18Pancytopenia (HP:0001876)3.56409204
19Acute necrotizing encephalopathy (HP:0006965)3.41098580
20Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.40163091
21Decreased activity of mitochondrial respiratory chain (HP:0008972)3.40163091
22Abnormal mitochondria in muscle tissue (HP:0008316)3.33784838
23Chronic diarrhea (HP:0002028)3.25317026
24Increased hepatocellular lipid droplets (HP:0006565)3.24133256
25Abnormality of T cells (HP:0002843)3.16398048
26Generalized aminoaciduria (HP:0002909)3.11313184
27Lipid accumulation in hepatocytes (HP:0006561)3.11028559
28Increased CSF lactate (HP:0002490)3.10225886
29Decreased electroretinogram (ERG) amplitude (HP:0000654)3.03961439
30Absent rod-and cone-mediated responses on ERG (HP:0007688)3.02406310
31Increased intramyocellular lipid droplets (HP:0012240)3.01520072
32Abolished electroretinogram (ERG) (HP:0000550)2.95206720
333-Methylglutaconic aciduria (HP:0003535)2.89518034
34Encephalitis (HP:0002383)2.77195662
35Attenuation of retinal blood vessels (HP:0007843)2.76740975
36Lymphopenia (HP:0001888)2.72905389
37Acute encephalopathy (HP:0006846)2.72159687
38Hypergammaglobulinemia (HP:0010702)2.71913615
39Hypoproteinemia (HP:0003075)2.71609061
40Progressive macrocephaly (HP:0004481)2.70091638
41Increased muscle lipid content (HP:0009058)2.64734595
42Abnormality of eosinophils (HP:0001879)2.63947004
43Amyotrophic lateral sclerosis (HP:0007354)2.55474613
44Renal Fanconi syndrome (HP:0001994)2.52750677
45Abnormality of cells of the lymphoid lineage (HP:0012140)2.48934574
46Stomatitis (HP:0010280)2.46378754
47Increased serum lactate (HP:0002151)2.44761070
48Clubbing of toes (HP:0100760)2.41624491
49Abnormality of the renal collecting system (HP:0004742)2.41255032
50Abnormal rod and cone electroretinograms (HP:0008323)2.38191696
51Abnormality of the prostate (HP:0008775)2.37794588
52IgM deficiency (HP:0002850)2.37783962
53Optic disc pallor (HP:0000543)2.36175642
54Decreased central vision (HP:0007663)2.34545569
55Eosinophilia (HP:0001880)2.27602494
56Recurrent bronchitis (HP:0002837)2.25329751
57Lactic acidosis (HP:0003128)2.23392784
58Duplicated collecting system (HP:0000081)2.23171820
59Aplasia/Hypoplasia of the uvula (HP:0010293)2.22646713
60Cerebral edema (HP:0002181)2.22060395
61Recurrent viral infections (HP:0004429)2.19339277
62Respiratory failure (HP:0002878)2.19012631
63Chromosomal breakage induced by crosslinking agents (HP:0003221)2.14719346
64Abnormality of the ileum (HP:0001549)2.14455189
65Joint swelling (HP:0001386)2.13841376
66Lymphoma (HP:0002665)2.13739743
67Meckel diverticulum (HP:0002245)2.12179297
68Exertional dyspnea (HP:0002875)2.11688274
69Hypoplasia of the thymus (HP:0000778)2.08875343
70Colon cancer (HP:0003003)2.08039807
71Retinal dysplasia (HP:0007973)2.07948526
72Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.04583592
73Keratoconus (HP:0000563)1.99828124
74Increased corneal curvature (HP:0100692)1.99828124
75Abnormality of macrophages (HP:0004311)1.98240525
76Glycosuria (HP:0003076)1.97850831
77Abnormality of urine glucose concentration (HP:0011016)1.97850831
78Granulocytopenia (HP:0001913)1.97386348
79Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.96703894
80Absent thumb (HP:0009777)1.95251397
81Cerebral palsy (HP:0100021)1.92498934
82Abnormality of dicarboxylic acid metabolism (HP:0010995)1.92381431
83Dicarboxylic aciduria (HP:0003215)1.92381431
84Methylmalonic acidemia (HP:0002912)1.88224855
85Leukocytosis (HP:0001974)1.87006610
86Meningitis (HP:0001287)1.86397532
87Gastrointestinal infarctions (HP:0005244)1.84355233
88CNS demyelination (HP:0007305)1.84226813
89Pendular nystagmus (HP:0012043)1.80921466
90Recurrent fungal infections (HP:0002841)1.80560193
91Chromsome breakage (HP:0040012)1.79422647
92Cellular immunodeficiency (HP:0005374)1.78825484
93Recurrent cutaneous fungal infections (HP:0011370)1.78667344
94Chronic mucocutaneous candidiasis (HP:0002728)1.78667344
95Abnormality of the preputium (HP:0100587)1.77668378
96Episodic fever (HP:0001954)1.76594873
97Congenital stationary night blindness (HP:0007642)1.76482907
98Erythema (HP:0010783)1.74211734
99Bronchitis (HP:0012387)1.71413158
100Renal cortical cysts (HP:0000803)1.70824141

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR6.45368911
2TESK25.63282404
3MAP3K123.33301419
4VRK22.78784178
5TESK12.78455909
6LIMK12.49200186
7BCKDK2.48789775
8BUB12.46046491
9TXK2.30499510
10TAOK32.24404504
11ITK2.22168709
12STK162.16314951
13WNK42.11224727
14MAP3K112.04711819
15ZAK1.86775488
16MAP4K11.85698987
17EIF2AK31.76561485
18NUAK11.67612950
19MAP4K21.62072140
20DAPK11.55457077
21ADRBK21.55131621
22MST41.50383667
23PINK11.48952577
24VRK11.47980742
25TLK11.45411482
26TAF11.44079151
27TEC1.39410490
28IKBKE1.38155276
29PRKCQ1.31372778
30STK391.20432414
31BLK1.12687644
32EIF2AK11.11977366
33NEK11.07640201
34SYK1.04223325
35GRK11.04188784
36RPS6KA41.02768778
37BCR1.02029189
38ZAP701.01139655
39MAPKAPK30.90562984
40GRK70.84414336
41MYLK0.82693182
42CDK80.82171538
43WEE10.76505120
44TBK10.76217074
45GRK50.75528041
46LCK0.73872314
47FES0.72096909
48CSF1R0.70839554
49PIK3CA0.70312245
50CAMKK20.66721441
51CSK0.66714991
52RPS6KA50.66287127
53FRK0.65131670
54OXSR10.62762093
55BTK0.61258246
56ERBB30.61232974
57DYRK20.61212745
58BMPR1B0.59088329
59AURKA0.57391290
60CSNK1G30.54730026
61LYN0.54289332
62WNK30.53300332
63TRPM70.52942895
64KIT0.49671703
65TNK20.49603149
66PLK40.47246673
67INSRR0.44745052
68CDC70.43850592
69DAPK20.43343853
70NME10.43048618
71PRKD30.42954182
72EIF2AK20.40596681
73CLK10.39890521
74CSNK1A1L0.39870746
75ROCK10.39157590
76CSNK1A10.39059084
77AURKB0.38037110
78PAK10.36109928
79TRIM280.35607110
80CSNK2A10.35062107
81ATR0.34683467
82PIK3CG0.34607657
83MAPKAPK20.32602605
84AKT30.32326352
85CDK70.32319105
86PLK10.32068577
87MUSK0.31886932
88CDK180.29818379
89CSNK1G10.29381231
90SMG10.29096713
91PRKCA0.28799094
92DAPK30.27840121
93CDK150.27478824
94PASK0.27260586
95IKBKB0.26457422
96FLT30.26298740
97TIE10.25143583
98CDK140.24696896
99OBSCN0.24669103
100STK100.24227920

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.29421288
2Primary immunodeficiency_Homo sapiens_hsa053405.15853974
3Oxidative phosphorylation_Homo sapiens_hsa001903.60991761
4Parkinsons disease_Homo sapiens_hsa050123.25642345
5Protein export_Homo sapiens_hsa030602.96888370
6Graft-versus-host disease_Homo sapiens_hsa053322.78044681
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.59244166
8DNA replication_Homo sapiens_hsa030302.50731912
9Antigen processing and presentation_Homo sapiens_hsa046122.48499494
10Mismatch repair_Homo sapiens_hsa034302.10469734
11Hematopoietic cell lineage_Homo sapiens_hsa046402.10315157
12Alzheimers disease_Homo sapiens_hsa050102.09368277
13Autoimmune thyroid disease_Homo sapiens_hsa053202.06806227
14Allograft rejection_Homo sapiens_hsa053302.02483808
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.96111466
16RNA polymerase_Homo sapiens_hsa030201.88234294
17Huntingtons disease_Homo sapiens_hsa050161.88064449
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.80578124
19T cell receptor signaling pathway_Homo sapiens_hsa046601.74427176
20Type I diabetes mellitus_Homo sapiens_hsa049401.69111381
21Homologous recombination_Homo sapiens_hsa034401.58098782
22Phototransduction_Homo sapiens_hsa047441.50446172
23Cardiac muscle contraction_Homo sapiens_hsa042601.46875215
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42018615
25Fanconi anemia pathway_Homo sapiens_hsa034601.40300190
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.30211895
27One carbon pool by folate_Homo sapiens_hsa006701.30170243
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.25572888
29Measles_Homo sapiens_hsa051621.24416283
30Shigellosis_Homo sapiens_hsa051311.21259954
31Ribosome_Homo sapiens_hsa030101.20290691
32Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.18951977
33Pyrimidine metabolism_Homo sapiens_hsa002401.18613346
34Folate biosynthesis_Homo sapiens_hsa007901.15688135
35Purine metabolism_Homo sapiens_hsa002301.05295290
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.04521981
37Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.01358355
38Rheumatoid arthritis_Homo sapiens_hsa053230.93980744
39Nucleotide excision repair_Homo sapiens_hsa034200.91264391
40Non-homologous end-joining_Homo sapiens_hsa034500.90306604
41Propanoate metabolism_Homo sapiens_hsa006400.86166386
42Base excision repair_Homo sapiens_hsa034100.85603434
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.82764924
44Linoleic acid metabolism_Homo sapiens_hsa005910.78415160
45RNA degradation_Homo sapiens_hsa030180.77414946
46Salmonella infection_Homo sapiens_hsa051320.77144479
47Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76503450
48Maturity onset diabetes of the young_Homo sapiens_hsa049500.76115862
49NF-kappa B signaling pathway_Homo sapiens_hsa040640.70145125
50Intestinal immune network for IgA production_Homo sapiens_hsa046720.65606979
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65431478
52Peroxisome_Homo sapiens_hsa041460.64520052
53Ether lipid metabolism_Homo sapiens_hsa005650.64114378
54Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.63432483
55Fatty acid elongation_Homo sapiens_hsa000620.62296461
56Butanoate metabolism_Homo sapiens_hsa006500.61134489
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60628255
58Steroid hormone biosynthesis_Homo sapiens_hsa001400.58551592
59Drug metabolism - other enzymes_Homo sapiens_hsa009830.58478734
60Spliceosome_Homo sapiens_hsa030400.57916645
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56630479
62Viral myocarditis_Homo sapiens_hsa054160.54354942
63Tryptophan metabolism_Homo sapiens_hsa003800.52891872
64Glutathione metabolism_Homo sapiens_hsa004800.51715755
65Steroid biosynthesis_Homo sapiens_hsa001000.51681943
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50742944
67Fatty acid degradation_Homo sapiens_hsa000710.49063875
68Systemic lupus erythematosus_Homo sapiens_hsa053220.47465799
69Herpes simplex infection_Homo sapiens_hsa051680.47394095
70Metabolic pathways_Homo sapiens_hsa011000.46384944
71Fatty acid metabolism_Homo sapiens_hsa012120.46092944
72Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.43856499
73Epstein-Barr virus infection_Homo sapiens_hsa051690.43520084
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.43354580
75Asthma_Homo sapiens_hsa053100.37264270
76Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.35983051
77Arachidonic acid metabolism_Homo sapiens_hsa005900.35460343
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.35030850
79Legionellosis_Homo sapiens_hsa051340.34510487
80Mineral absorption_Homo sapiens_hsa049780.33912987
81Sulfur metabolism_Homo sapiens_hsa009200.32945706
82Regulation of autophagy_Homo sapiens_hsa041400.31363325
83Olfactory transduction_Homo sapiens_hsa047400.30911007
84Malaria_Homo sapiens_hsa051440.30351449
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.28854389
86Selenocompound metabolism_Homo sapiens_hsa004500.28849819
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26937398
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.26594053
89Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.26100379
90RNA transport_Homo sapiens_hsa030130.25774640
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.24801194
922-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.24417472
93Sphingolipid metabolism_Homo sapiens_hsa006000.23036647
94Basal transcription factors_Homo sapiens_hsa030220.23005336
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.21532380
96Apoptosis_Homo sapiens_hsa042100.19946714
97Chemical carcinogenesis_Homo sapiens_hsa052040.19116158
98Cysteine and methionine metabolism_Homo sapiens_hsa002700.16517340
99Nitrogen metabolism_Homo sapiens_hsa009100.16362853
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.16359953

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