HMGN2P23

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine metabolic process (GO:0046087)9.91044034
2cytidine catabolic process (GO:0006216)9.91044034
3cytidine deamination (GO:0009972)9.91044034
4DNA deamination (GO:0045006)8.85280525
5pyrimidine ribonucleoside catabolic process (GO:0046133)8.82428260
6Arp2/3 complex-mediated actin nucleation (GO:0034314)8.00208457
7actin nucleation (GO:0045010)7.16545756
8sequestering of actin monomers (GO:0042989)6.92631843
9negative regulation of stress fiber assembly (GO:0051497)5.92639365
10T cell migration (GO:0072678)5.60529800
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.45427313
12negative regulation of T cell apoptotic process (GO:0070233)5.27459170
13negative regulation by host of viral transcription (GO:0043922)5.05958398
14positive regulation of natural killer cell mediated immunity (GO:0002717)4.96175207
15positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.92949239
16macrophage chemotaxis (GO:0048246)4.87584839
17cytolysis (GO:0019835)4.80199102
18regulation of B cell receptor signaling pathway (GO:0050855)4.58092665
19positive thymic T cell selection (GO:0045059)4.57359040
20negative regulation of monooxygenase activity (GO:0032769)4.57354561
21negative regulation of actin filament bundle assembly (GO:0032232)4.56812276
22pyrimidine nucleoside catabolic process (GO:0046135)4.53804254
23positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.53661600
24positive T cell selection (GO:0043368)4.52140488
25regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.38456256
26regulation of natural killer cell mediated immunity (GO:0002715)4.38456256
27eosinophil chemotaxis (GO:0048245)4.34221901
28cellular response to interleukin-15 (GO:0071350)4.27264825
29negative regulation of oxidoreductase activity (GO:0051354)4.14647156
30negative regulation of viral genome replication (GO:0045071)4.14634420
31mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.13112260
32positive regulation of lamellipodium assembly (GO:0010592)4.10848712
33positive regulation of T cell mediated cytotoxicity (GO:0001916)3.97315964
34eosinophil migration (GO:0072677)3.93990687
35regulation of leukocyte mediated cytotoxicity (GO:0001910)3.89658608
36positive regulation of cell killing (GO:0031343)3.88416572
37positive regulation of translational initiation (GO:0045948)3.87757401
38negative regulation of lymphocyte apoptotic process (GO:0070229)3.77701348
39regulation of activation of Janus kinase activity (GO:0010533)3.72636715
40positive regulation of calcium-mediated signaling (GO:0050850)3.70381631
41antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.64143613
42positive regulation of monocyte chemotaxis (GO:0090026)3.63124082
43positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.58121860
44positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.51942490
45regulation of cellular amino acid metabolic process (GO:0006521)3.47835666
46regulation of lymphocyte chemotaxis (GO:1901623)3.46399670
47positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.44551079
48antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.43970563
49regulation of cell killing (GO:0031341)3.39762025
50ATP synthesis coupled proton transport (GO:0015986)3.39186909
51energy coupled proton transport, down electrochemical gradient (GO:0015985)3.39186909
52regulation of T cell chemotaxis (GO:0010819)3.38594247
53positive regulation of T cell chemotaxis (GO:0010820)3.38594247
54positive regulation of interleukin-8 secretion (GO:2000484)3.35489005
55negative regulation of calcium ion transport into cytosol (GO:0010523)3.28530354
56positive regulation of lamellipodium organization (GO:1902745)3.28333621
57lymphocyte migration (GO:0072676)3.28048347
58regulation of T cell mediated cytotoxicity (GO:0001914)3.26819327
59cellular defense response (GO:0006968)3.26806636
60T cell receptor signaling pathway (GO:0050852)3.23654253
61thymic T cell selection (GO:0045061)3.23443424
62negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.23071260
63mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.22947294
64regulation of T cell apoptotic process (GO:0070232)3.22802586
65DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.21851612
66negative T cell selection (GO:0043383)3.21380430
67metallo-sulfur cluster assembly (GO:0031163)3.20844887
68iron-sulfur cluster assembly (GO:0016226)3.20844887
69negative regulation of nitric-oxide synthase activity (GO:0051001)3.16443427
70regulation of viral genome replication (GO:0045069)3.11792064
71intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.11203524
72signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.11203524
73positive regulation of B cell differentiation (GO:0045579)3.07413515
74respiratory electron transport chain (GO:0022904)3.04850963
75signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.04417493
76signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.04417493
77signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.04417493
78response to interleukin-15 (GO:0070672)3.04095014
79protein neddylation (GO:0045116)3.03558158
80regulation of vitamin D biosynthetic process (GO:0060556)3.02123320
81regulation of T cell receptor signaling pathway (GO:0050856)3.01609324
82negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.00434154
83lymphocyte chemotaxis (GO:0048247)3.00073746
84positive regulation of lymphocyte migration (GO:2000403)2.99716916
85T cell costimulation (GO:0031295)2.98356190
86electron transport chain (GO:0022900)2.95846359
87regulation of T cell tolerance induction (GO:0002664)2.95473352
88regulation of chronic inflammatory response (GO:0002676)2.95144328
89lymphocyte costimulation (GO:0031294)2.94849658
90regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.91526840
91positive regulation of tolerance induction (GO:0002645)2.90218709
92dendritic cell chemotaxis (GO:0002407)2.88130909
93signal transduction involved in DNA damage checkpoint (GO:0072422)2.86937025
94signal transduction involved in DNA integrity checkpoint (GO:0072401)2.86937025
95regulation of regulatory T cell differentiation (GO:0045589)2.85586567
96positive regulation of gamma-delta T cell activation (GO:0046645)2.84825498
97negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.83067036
98signal transduction involved in cell cycle checkpoint (GO:0072395)2.82520204
99T cell selection (GO:0045058)2.82490108
100regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:004509110.2085720

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.64153191
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.66496090
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.52290133
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.45733171
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.92710557
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.52340766
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.32063886
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.06508786
9MYB_26560356_Chip-Seq_TH2_Human3.04143683
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.91569343
11RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.91382786
12VDR_22108803_ChIP-Seq_LS180_Human2.70266358
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.61706555
14STAT4_19710469_ChIP-ChIP_TH1__Mouse2.49818246
15LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.40725499
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.23133919
17RUNX_20019798_ChIP-Seq_JUKART_Human2.15808530
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.11291852
19EZH2_22144423_ChIP-Seq_EOC_Human2.09446739
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.05470086
21GATA3_27048872_Chip-Seq_THYMUS_Human2.01111963
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.00491527
23FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.90235321
24RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81368236
25NOTCH1_21737748_ChIP-Seq_TLL_Human1.79401320
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.76621197
27HTT_18923047_ChIP-ChIP_STHdh_Human1.76531821
28MYB_26560356_Chip-Seq_TH1_Human1.76164912
29UTX_26944678_Chip-Seq_JUKART_Human1.75203854
30JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.72019599
31GATA3_26560356_Chip-Seq_TH2_Human1.70238715
32EST1_17652178_ChIP-ChIP_JURKAT_Human1.68184566
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.67861617
34FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.62951852
35VDR_23849224_ChIP-Seq_CD4+_Human1.57239602
36STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.53325144
37GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.49715932
38SRF_21415370_ChIP-Seq_HL-1_Mouse1.48445374
39MAF_26560356_Chip-Seq_TH1_Human1.47616293
40TAF2_19829295_ChIP-Seq_ESCs_Human1.43975074
41CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.43338823
42LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.42881303
43MAF_26560356_Chip-Seq_TH2_Human1.42224993
44RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.41663445
45MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.37719921
46ERG_20517297_ChIP-Seq_VCAP_Human1.36190185
47HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.35497195
48TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.33797010
49TP53_22573176_ChIP-Seq_HFKS_Human1.31996841
50IGF1R_20145208_ChIP-Seq_DFB_Human1.31928387
51E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.31526859
52PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.28467071
53ER_23166858_ChIP-Seq_MCF-7_Human1.20105413
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19301594
55BCL6_27268052_Chip-Seq_Bcells_Human1.18440207
56CIITA_25753668_ChIP-Seq_RAJI_Human1.11964166
57GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.11964037
58AR_20517297_ChIP-Seq_VCAP_Human1.10439422
59PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.09190612
60CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.08807179
61MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.07490841
62CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07062432
63GATA3_21878914_ChIP-Seq_MCF-7_Human1.06767208
64SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.05446814
65FOXP3_21729870_ChIP-Seq_TREG_Human1.04588410
66SPI1_23547873_ChIP-Seq_NB4_Human1.04244576
67POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03701848
68RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.02386832
69POU5F1_16153702_ChIP-ChIP_HESCs_Human1.02230902
70NANOG_20526341_ChIP-Seq_ESCs_Human1.01213642
71PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00660669
72CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.00196749
73FLI1_27457419_Chip-Seq_LIVER_Mouse0.96096114
74NANOG_19829295_ChIP-Seq_ESCs_Human0.95383652
75SOX2_19829295_ChIP-Seq_ESCs_Human0.95383652
76P300_27268052_Chip-Seq_Bcells_Human0.94613072
77MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.94561121
78EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.94249924
79CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.93966021
80SA1_27219007_Chip-Seq_Bcells_Human0.93654918
81EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.93534652
82TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.93143202
83MYC_19829295_ChIP-Seq_ESCs_Human0.93009055
84MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.92597429
85PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92251931
86FOXA1_25329375_ChIP-Seq_VCAP_Human0.92236160
87FOXA1_27270436_Chip-Seq_PROSTATE_Human0.92236160
88GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.91284046
89GATA6_21074721_ChIP-Seq_CACO-2_Human0.90945615
90FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90352217
91FOXH1_21741376_ChIP-Seq_EPCs_Human0.90219423
92NFE2_27457419_Chip-Seq_LIVER_Mouse0.87426252
93AUTS2_25519132_ChIP-Seq_293T-REX_Human0.86541067
94STAT6_21828071_ChIP-Seq_BEAS2B_Human0.85577962
95GATA3_26560356_Chip-Seq_TH1_Human0.85470301
96EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.84182025
97RBPJ_21746931_ChIP-Seq_IB4_Human0.83290711
98ELF1_20517297_ChIP-Seq_JURKAT_Human0.82693084
99PHF8_20622853_ChIP-Seq_HELA_Human0.82154237
100BMI1_23680149_ChIP-Seq_NPCS_Mouse0.79524320

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.80528697
2MP0009333_abnormal_splenocyte_physiolog3.92501642
3MP0003763_abnormal_thymus_physiology3.38904485
4MP0006082_CNS_inflammation3.25091693
5MP0009785_altered_susceptibility_to3.22994575
6MP0001835_abnormal_antigen_presentation3.09816567
7MP0004147_increased_porphyrin_level2.87669566
8MP0002166_altered_tumor_susceptibility2.85393416
9MP0005000_abnormal_immune_tolerance2.58970145
10MP0005025_abnormal_response_to2.32479317
11MP0002420_abnormal_adaptive_immunity2.31433397
12MP0001800_abnormal_humoral_immune2.29696716
13MP0001819_abnormal_immune_cell2.20547892
14MP0002723_abnormal_immune_serum2.18122230
15MP0002006_tumorigenesis2.07504124
16MP0001873_stomach_inflammation2.06442875
17MP0005464_abnormal_platelet_physiology2.03512143
18MP0002148_abnormal_hypersensitivity_rea2.02246318
19MP0000685_abnormal_immune_system1.99849227
20MP0003448_altered_tumor_morphology1.91076761
21MP0001790_abnormal_immune_system1.90189545
22MP0005387_immune_system_phenotype1.90189545
23MP0002452_abnormal_antigen_presenting1.83137099
24MP0002933_joint_inflammation1.78863081
25MP0006054_spinal_hemorrhage1.76419273
26MP0002398_abnormal_bone_marrow1.68784112
27MP0002405_respiratory_system_inflammati1.65231849
28MP0004145_abnormal_muscle_electrophysio1.63501143
29MP0000716_abnormal_immune_system1.60483334
30MP0001905_abnormal_dopamine_level1.53278255
31MP0001845_abnormal_inflammatory_respons1.50850371
32MP0003866_abnormal_defecation1.50398540
33MP0003283_abnormal_digestive_organ1.50062086
34MP0001485_abnormal_pinna_reflex1.49469696
35MP0010386_abnormal_urinary_bladder1.48656876
36MP0002722_abnormal_immune_system1.47076008
37MP0010155_abnormal_intestine_physiology1.46343845
38MP0002138_abnormal_hepatobiliary_system1.42838513
39MP0000689_abnormal_spleen_morphology1.41936151
40MP0002419_abnormal_innate_immunity1.39985815
41MP0000703_abnormal_thymus_morphology1.36141517
42MP0003786_premature_aging1.35163020
43MP0000372_irregular_coat_pigmentation1.31020968
44MP0003075_altered_response_to1.30906085
45MP0002102_abnormal_ear_morphology1.28562904
46MP0002429_abnormal_blood_cell1.25745950
47MP0002876_abnormal_thyroid_physiology1.23797488
48MP0002837_dystrophic_cardiac_calcinosis1.20337194
49MP0003436_decreased_susceptibility_to1.19816375
50MP0001919_abnormal_reproductive_system1.19688092
51MP0005645_abnormal_hypothalamus_physiol1.19432335
52MP0002736_abnormal_nociception_after1.18685322
53MP0001968_abnormal_touch/_nociception1.18208313
54MP0001765_abnormal_ion_homeostasis1.18191930
55MP0001188_hyperpigmentation1.17110971
56MP0005551_abnormal_eye_electrophysiolog1.15438679
57MP0005166_decreased_susceptibility_to1.14597564
58MP0005083_abnormal_biliary_tract1.13493852
59MP0001661_extended_life_span1.12912049
60MP0008469_abnormal_protein_level1.09551058
61MP0009763_increased_sensitivity_to1.09429241
62MP0005084_abnormal_gallbladder_morpholo1.08911647
63MP0008872_abnormal_physiological_respon1.06581818
64MP0003045_fibrosis1.06414412
65MP0004742_abnormal_vestibular_system1.04655512
66MP0003137_abnormal_impulse_conducting1.03466308
67MP0001542_abnormal_bone_strength1.01581288
68MP0009379_abnormal_foot_pigmentation1.00093428
69MP0001853_heart_inflammation0.97813826
70MP0005636_abnormal_mineral_homeostasis0.96893963
71MP0005646_abnormal_pituitary_gland0.92811618
72MP0003806_abnormal_nucleotide_metabolis0.92034537
73MP0001727_abnormal_embryo_implantation0.91216359
74MP0001666_abnormal_nutrient_absorption0.90647717
75MP0003567_abnormal_fetal_cardiomyocyte0.88583125
76MP0005410_abnormal_fertilization0.88268268
77MP0004947_skin_inflammation0.87446694
78MP0000858_altered_metastatic_potential0.87371369
79MP0000604_amyloidosis0.87276473
80MP0008877_abnormal_DNA_methylation0.83411166
81MP0002693_abnormal_pancreas_physiology0.81576835
82MP0005389_reproductive_system_phenotype0.78931944
83MP0002019_abnormal_tumor_incidence0.78629080
84MP0003252_abnormal_bile_duct0.77268049
85MP0009643_abnormal_urine_homeostasis0.75274872
86MP0000639_abnormal_adrenal_gland0.74715842
87MP0005451_abnormal_body_composition0.74004852
88MP0009764_decreased_sensitivity_to0.71940872
89MP0001533_abnormal_skeleton_physiology0.71522634
90MP0008995_early_reproductive_senescence0.70750404
91MP0003646_muscle_fatigue0.69463038
92MP0005075_abnormal_melanosome_morpholog0.67694634
93MP0005319_abnormal_enzyme/_coenzyme0.67677457
94MP0003878_abnormal_ear_physiology0.63767722
95MP0005377_hearing/vestibular/ear_phenot0.63767722
96MP0006072_abnormal_retinal_apoptosis0.63424962
97MP0001764_abnormal_homeostasis0.63253356
98MP0001119_abnormal_female_reproductive0.63029923
99MP0000343_altered_response_to0.62514298
100MP0004134_abnormal_chest_morphology0.62126277

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of B cell number (HP:0010975)5.85059888
2B lymphocytopenia (HP:0010976)5.84661848
3T lymphocytopenia (HP:0005403)5.68129400
4Increased IgM level (HP:0003496)5.43931466
5Abnormality of T cell number (HP:0011839)5.34305779
6IgG deficiency (HP:0004315)5.33261332
7Hypoproteinemia (HP:0003075)5.05447284
8Aplastic anemia (HP:0001915)4.63001864
9Autoimmune hemolytic anemia (HP:0001890)4.46471404
10Severe combined immunodeficiency (HP:0004430)4.39911418
11Thyroiditis (HP:0100646)4.18808195
12Elevated erythrocyte sedimentation rate (HP:0003565)3.83164515
13Encephalitis (HP:0002383)3.60148169
14Combined immunodeficiency (HP:0005387)3.58203218
15Abnormality of eosinophils (HP:0001879)3.57371254
16Acute hepatic failure (HP:0006554)3.44139976
17Absent rod-and cone-mediated responses on ERG (HP:0007688)3.41565739
18Abolished electroretinogram (ERG) (HP:0000550)3.32742341
19Abnormality of the prostate (HP:0008775)3.26481688
20Acute necrotizing encephalopathy (HP:0006965)3.22599073
21Recurrent cutaneous fungal infections (HP:0011370)3.20281532
22Chronic mucocutaneous candidiasis (HP:0002728)3.20281532
23Stomatitis (HP:0010280)3.19340704
24Hypoplasia of the thymus (HP:0000778)3.18938571
25Abnormality of macrophages (HP:0004311)3.16652891
26Abnormality of T cells (HP:0002843)3.10797568
27Gastrointestinal infarctions (HP:0005244)3.00024269
28Mitochondrial inheritance (HP:0001427)2.99379260
29Chronic diarrhea (HP:0002028)2.98033526
30Severe visual impairment (HP:0001141)2.96246381
31Cerebral edema (HP:0002181)2.94757790
32Abnormal mitochondria in muscle tissue (HP:0008316)2.93558610
33Decreased central vision (HP:0007663)2.93266397
34Hypoalbuminemia (HP:0003073)2.89529232
35Abnormal albumin level (HP:0012116)2.89529232
36Eosinophilia (HP:0001880)2.86989743
37Leukocytosis (HP:0001974)2.74136466
38Lymphopenia (HP:0001888)2.72141777
39Progressive macrocephaly (HP:0004481)2.70955973
40Meningitis (HP:0001287)2.69138526
41Hemiplegia (HP:0002301)2.68645136
42Autoimmune thrombocytopenia (HP:0001973)2.67034403
43Renal Fanconi syndrome (HP:0001994)2.66734501
44Abnormal rod and cone electroretinograms (HP:0008323)2.66314183
45Hypergammaglobulinemia (HP:0010702)2.65870774
46Decreased activity of mitochondrial respiratory chain (HP:0008972)2.60420061
47Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.60420061
48Abnormality of cells of the lymphoid lineage (HP:0012140)2.53835365
49Tetraplegia (HP:0002445)2.52443044
50Obstructive lung disease (HP:0006536)2.48694674
51Chronic obstructive pulmonary disease (HP:0006510)2.48694674
52Radial bowing (HP:0002986)2.46956601
53Pendular nystagmus (HP:0012043)2.41950219
54Keratoconus (HP:0000563)2.41167102
55Increased corneal curvature (HP:0100692)2.41167102
56Acute encephalopathy (HP:0006846)2.40548032
57Pancytopenia (HP:0001876)2.39681230
58Mediastinal lymphadenopathy (HP:0100721)2.39349437
59Recurrent bronchitis (HP:0002837)2.35863634
60Diplopia (HP:0000651)2.26072671
61Abnormality of binocular vision (HP:0011514)2.26072671
62Recurrent fungal infections (HP:0002841)2.25333293
63Lymphoma (HP:0002665)2.19768635
64Agammaglobulinemia (HP:0004432)2.18999638
65Increased intramyocellular lipid droplets (HP:0012240)2.18801156
66Generalized aminoaciduria (HP:0002909)2.18262793
67Ureteral stenosis (HP:0000071)2.13601133
68Decreased electroretinogram (ERG) amplitude (HP:0000654)2.12595021
69Increased CSF lactate (HP:0002490)2.12406843
70Recurrent viral infections (HP:0004429)2.10166391
71Chest pain (HP:0100749)2.08791703
72Type I transferrin isoform profile (HP:0003642)2.05867559
73Granulocytopenia (HP:0001913)2.05384616
74Congenital stationary night blindness (HP:0007642)1.98887027
75Amyotrophic lateral sclerosis (HP:0007354)1.93952968
76Attenuation of retinal blood vessels (HP:0007843)1.92576536
77Ureteral obstruction (HP:0006000)1.90457275
78Gangrene (HP:0100758)1.90078145
79Reduced antithrombin III activity (HP:0001976)1.89762158
80Abnormal delayed hypersensitivity skin test (HP:0002963)1.83913889
81Joint swelling (HP:0001386)1.83345405
82Increased hepatocellular lipid droplets (HP:0006565)1.82879207
83Pancreatic fibrosis (HP:0100732)1.82608713
84Erythema (HP:0010783)1.82198553
85Spontaneous hematomas (HP:0007420)1.81205559
86Cellular immunodeficiency (HP:0005374)1.80458533
87Pigmentary retinal degeneration (HP:0001146)1.79885602
883-Methylglutaconic aciduria (HP:0003535)1.78870596
89Lethargy (HP:0001254)1.78545548
90Pancreatic islet-cell hyperplasia (HP:0004510)1.74116060
91Hepatocellular necrosis (HP:0001404)1.73930072
92Increased muscle lipid content (HP:0009058)1.73584190
93Recurrent abscess formation (HP:0002722)1.72801362
94Pustule (HP:0200039)1.69829813
95Pancreatitis (HP:0001733)1.69749230
96Abnormality of male internal genitalia (HP:0000022)1.68072534
97Orthostatic hypotension (HP:0001278)1.63976979
98True hermaphroditism (HP:0010459)1.62990483
99Hemoptysis (HP:0002105)1.62988273
100Pulmonary embolism (HP:0002204)1.62578805

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.99354588
2KDR6.59062192
3TESK25.89473525
4TESK13.02378102
5TXK2.90360009
6MAP3K122.57554867
7GRK62.55683570
8ITK2.39859565
9MAP4K12.27350164
10LIMK12.26063504
11TNK21.91630278
12TEC1.74047172
13MAP3K111.72702442
14TAOK31.64222152
15MYLK1.59166511
16GRK71.52805112
17ADRBK21.52595756
18MAP2K71.48753475
19VRK21.37467438
20GRK11.36535606
21BTK1.36151031
22SYK1.32805854
23RPS6KA41.23902678
24FES1.17353258
25PRKCQ1.09109318
26MAP4K21.08732943
27CSNK1G31.03967858
28CSK1.02484769
29BUB11.02043321
30TBK11.00225185
31CSF1R0.96759592
32LCK0.96567998
33MATK0.96296767
34VRK10.89230869
35TIE10.82691624
36NUAK10.80267626
37LYN0.77367307
38CSNK1A1L0.74584777
39AURKA0.74503042
40STK160.72217783
41FRK0.68608362
42CSNK1G10.67176018
43PRKCH0.62763047
44PAK10.62359970
45PAK40.61189504
46INSRR0.59840226
47PTK2B0.59312646
48DAPK10.58897760
49MAP3K10.58041677
50ILK0.57529818
51RIPK40.56958569
52IKBKE0.56509575
53CSNK1G20.55995403
54MAPKAPK30.52086440
55ROCK10.48961852
56RPS6KA50.48724850
57FYN0.48606056
58PIK3CG0.48488868
59IKBKB0.46371420
60OBSCN0.45939876
61EPHB10.45898512
62BMPR20.45727209
63MAPK130.43614993
64SCYL20.41624160
65NTRK10.40421196
66PRKCA0.39560061
67JAK30.37466850
68ZAP700.37116143
69PINK10.34963624
70INSR0.34049351
71GRK50.33394449
72BRSK10.32210389
73MAPKAPK20.31560058
74PLK20.31134641
75IGF1R0.31077797
76TLK10.30980629
77PRKACA0.30612636
78WNK30.30111380
79MAP3K50.29816478
80DAPK30.29736123
81ERBB20.27606761
82BLK0.27346340
83PIK3CA0.27294564
84MUSK0.26981558
85PRKCD0.25372664
86MAPK110.25095638
87CSNK2A10.24432388
88ABL10.24304595
89JAK20.24206188
90CSNK1A10.23309329
91MELK0.23209690
92NME10.22768538
93CLK10.22087965
94KIT0.22083441
95ATR0.21916503
96TAOK20.21519664
97TAOK10.20858443
98CDK80.20857615
99BMPR1B0.20381873
100TRPM70.19233222

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.86514845
2Proteasome_Homo sapiens_hsa030505.03848851
3Graft-versus-host disease_Homo sapiens_hsa053323.30381954
4Oxidative phosphorylation_Homo sapiens_hsa001903.18182397
5Autoimmune thyroid disease_Homo sapiens_hsa053203.17556556
6Allograft rejection_Homo sapiens_hsa053303.11508223
7Antigen processing and presentation_Homo sapiens_hsa046122.75458959
8Hematopoietic cell lineage_Homo sapiens_hsa046402.68118509
9Parkinsons disease_Homo sapiens_hsa050122.62924071
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.53496847
11T cell receptor signaling pathway_Homo sapiens_hsa046602.48370235
12Type I diabetes mellitus_Homo sapiens_hsa049402.39609857
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.26798150
14RNA polymerase_Homo sapiens_hsa030202.09256688
15Alzheimers disease_Homo sapiens_hsa050101.99852949
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.77600299
17Protein export_Homo sapiens_hsa030601.72289250
18Viral myocarditis_Homo sapiens_hsa054161.69587104
19Huntingtons disease_Homo sapiens_hsa050161.62255278
20Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.59194883
21Shigellosis_Homo sapiens_hsa051311.47446736
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.45903264
23Rheumatoid arthritis_Homo sapiens_hsa053231.41729309
24Phototransduction_Homo sapiens_hsa047441.39733808
25Salmonella infection_Homo sapiens_hsa051321.35975631
26Measles_Homo sapiens_hsa051621.30582311
27Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.23427622
28Homologous recombination_Homo sapiens_hsa034401.22261674
29SNARE interactions in vesicular transport_Homo sapiens_hsa041301.18670299
30Pyrimidine metabolism_Homo sapiens_hsa002401.15777091
31Cardiac muscle contraction_Homo sapiens_hsa042601.15530141
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.13778115
33DNA replication_Homo sapiens_hsa030301.09447408
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.07801616
35Asthma_Homo sapiens_hsa053101.04183055
36Ribosome_Homo sapiens_hsa030101.03860230
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.98596389
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.94198668
39Systemic lupus erythematosus_Homo sapiens_hsa053220.89868796
40Mismatch repair_Homo sapiens_hsa034300.88912701
41Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.87061040
42Nitrogen metabolism_Homo sapiens_hsa009100.86441880
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85161010
44Malaria_Homo sapiens_hsa051440.84928334
45Linoleic acid metabolism_Homo sapiens_hsa005910.83909030
46Purine metabolism_Homo sapiens_hsa002300.81453636
47alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.81127291
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72051813
49NF-kappa B signaling pathway_Homo sapiens_hsa040640.68847413
50Staphylococcus aureus infection_Homo sapiens_hsa051500.67645443
51Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.67162453
52One carbon pool by folate_Homo sapiens_hsa006700.65242981
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62515264
54Taste transduction_Homo sapiens_hsa047420.61925828
55Olfactory transduction_Homo sapiens_hsa047400.57623330
56Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57171636
57Fanconi anemia pathway_Homo sapiens_hsa034600.55843632
58Toll-like receptor signaling pathway_Homo sapiens_hsa046200.52260735
59Drug metabolism - other enzymes_Homo sapiens_hsa009830.51554371
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49192540
61Epstein-Barr virus infection_Homo sapiens_hsa051690.48427238
62Steroid biosynthesis_Homo sapiens_hsa001000.48080372
63Vascular smooth muscle contraction_Homo sapiens_hsa042700.41729426
64Chemokine signaling pathway_Homo sapiens_hsa040620.41541079
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.40222836
66Collecting duct acid secretion_Homo sapiens_hsa049660.38428637
67Sulfur metabolism_Homo sapiens_hsa009200.37776954
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.37144935
69RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.35470158
70Prion diseases_Homo sapiens_hsa050200.35149670
71Propanoate metabolism_Homo sapiens_hsa006400.34842989
72Herpes simplex infection_Homo sapiens_hsa051680.34312020
73Caffeine metabolism_Homo sapiens_hsa002320.34146273
74Apoptosis_Homo sapiens_hsa042100.33842342
75Fat digestion and absorption_Homo sapiens_hsa049750.33015615
76HTLV-I infection_Homo sapiens_hsa051660.29097261
77Chemical carcinogenesis_Homo sapiens_hsa052040.28642815
78Arachidonic acid metabolism_Homo sapiens_hsa005900.27926973
79RNA degradation_Homo sapiens_hsa030180.27495806
80Alcoholism_Homo sapiens_hsa050340.27477888
81NOD-like receptor signaling pathway_Homo sapiens_hsa046210.26888250
82Endocytosis_Homo sapiens_hsa041440.25996994
83Ether lipid metabolism_Homo sapiens_hsa005650.25093845
84Peroxisome_Homo sapiens_hsa041460.24858935
85Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.24783230
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.23526699
87Nucleotide excision repair_Homo sapiens_hsa034200.22995985
88Metabolic pathways_Homo sapiens_hsa011000.22745511
89N-Glycan biosynthesis_Homo sapiens_hsa005100.18679651
90Leishmaniasis_Homo sapiens_hsa051400.18142913
91Retinol metabolism_Homo sapiens_hsa008300.17963080
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.16585266
93Platelet activation_Homo sapiens_hsa046110.16275677
94Renin secretion_Homo sapiens_hsa049240.15888304
95Sphingolipid metabolism_Homo sapiens_hsa006000.15385878
96Tyrosine metabolism_Homo sapiens_hsa003500.15313622
97Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.15294590
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.14025816
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.12322271
100Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.10713282

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