HMGB3P6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of protein localization to mitochondrial membrane (GO:0090151)6.20562296
2chaperone-mediated protein transport (GO:0072321)5.61746235
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.28263238
4ATP synthesis coupled proton transport (GO:0015986)5.28263238
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.97530710
6mitochondrial respiratory chain complex I assembly (GO:0032981)4.61418585
7NADH dehydrogenase complex assembly (GO:0010257)4.61418585
8mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.61418585
9otic vesicle formation (GO:0030916)4.45644587
10ribosomal small subunit assembly (GO:0000028)4.43279543
11mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.34394745
12protein complex biogenesis (GO:0070271)4.32469807
13neuron fate determination (GO:0048664)4.29758322
14protein-cofactor linkage (GO:0018065)4.13485129
15maturation of SSU-rRNA (GO:0030490)4.03468413
16respiratory electron transport chain (GO:0022904)4.02533279
17behavioral response to nicotine (GO:0035095)3.96279320
18electron transport chain (GO:0022900)3.95243223
19mitochondrial respiratory chain complex assembly (GO:0033108)3.91072652
20viral transcription (GO:0019083)3.81704229
21translational termination (GO:0006415)3.74378544
22cotranslational protein targeting to membrane (GO:0006613)3.72884864
23exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.71626281
24peptidyl-histidine modification (GO:0018202)3.69373198
25nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.60057499
26SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.57567489
27inner mitochondrial membrane organization (GO:0007007)3.55697236
28protein targeting to ER (GO:0045047)3.50056373
29platelet dense granule organization (GO:0060155)3.43231936
30epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.42727583
31spinal cord association neuron differentiation (GO:0021527)3.42290833
32proteasome assembly (GO:0043248)3.42258654
33transcription elongation from RNA polymerase III promoter (GO:0006385)3.40213576
34termination of RNA polymerase III transcription (GO:0006386)3.40213576
35kinetochore assembly (GO:0051382)3.39624843
36regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.36734778
37regulation of mitotic spindle checkpoint (GO:1903504)3.36734778
38protein localization to endoplasmic reticulum (GO:0070972)3.32598395
39intracellular protein transmembrane import (GO:0044743)3.32359584
40protein neddylation (GO:0045116)3.31016152
41establishment of protein localization to endoplasmic reticulum (GO:0072599)3.29012311
42neuron fate specification (GO:0048665)3.25178041
43maturation of 5.8S rRNA (GO:0000460)3.19790317
44pseudouridine synthesis (GO:0001522)3.18351194
45DNA double-strand break processing (GO:0000729)3.17600261
46translational elongation (GO:0006414)3.15755075
47DNA deamination (GO:0045006)3.14767047
48DNA damage response, detection of DNA damage (GO:0042769)3.08011484
49kinetochore organization (GO:0051383)3.07133120
50ribosomal small subunit biogenesis (GO:0042274)3.07128711
51DNA demethylation (GO:0080111)3.02934442
52nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.02533427
53translation (GO:0006412)3.00634780
54ATP biosynthetic process (GO:0006754)2.98624173
55epithelial cilium movement (GO:0003351)2.96675212
56reciprocal meiotic recombination (GO:0007131)2.92879256
57reciprocal DNA recombination (GO:0035825)2.92879256
58purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.92257769
59cellular protein complex disassembly (GO:0043624)2.88026451
60neurotransmitter catabolic process (GO:0042135)2.87892748
61cell proliferation in forebrain (GO:0021846)2.87464009
62translational initiation (GO:0006413)2.87119910
63purine nucleoside triphosphate biosynthetic process (GO:0009145)2.85780358
64chromatin remodeling at centromere (GO:0031055)2.84137526
65viral life cycle (GO:0019058)2.82868421
66CENP-A containing nucleosome assembly (GO:0034080)2.82249395
67ubiquinone metabolic process (GO:0006743)2.81860917
68regulation of mitochondrial translation (GO:0070129)2.80775865
69protein targeting to mitochondrion (GO:0006626)2.80436362
70protein localization to mitochondrion (GO:0070585)2.78439310
71ribonucleoside triphosphate biosynthetic process (GO:0009201)2.77169360
72cellular component biogenesis (GO:0044085)2.76742673
73ubiquinone biosynthetic process (GO:0006744)2.75656216
74protein K6-linked ubiquitination (GO:0085020)2.75600204
75GTP biosynthetic process (GO:0006183)2.72097488
76establishment of protein localization to mitochondrion (GO:0072655)2.71522057
77negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.70432727
78pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.70264288
79somite development (GO:0061053)2.68502270
80pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.67126549
81pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.66231795
82CTP metabolic process (GO:0046036)2.64860737
83CTP biosynthetic process (GO:0006241)2.64860737
84G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.63952984
85replication fork processing (GO:0031297)2.62346965
86organelle disassembly (GO:1903008)2.62107102
87negative regulation of transcription regulatory region DNA binding (GO:2000678)2.61777079
88negative regulation of DNA-dependent DNA replication (GO:2000104)2.60495031
89tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.59925502
90RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.59925502
91DNA ligation (GO:0006266)2.59440774
92cellular biogenic amine catabolic process (GO:0042402)2.55522137
93amine catabolic process (GO:0009310)2.55522137
94negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.55055416
95negative regulation of ligase activity (GO:0051352)2.55055416
96synaptic transmission, cholinergic (GO:0007271)2.53411431
97hydrogen ion transmembrane transport (GO:1902600)2.52433375
98protein complex disassembly (GO:0043241)2.50791577
99cilium movement (GO:0003341)2.50237260
100regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.50049615

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.25996137
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.87437534
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.75337909
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.23533446
5RBPJ_22232070_ChIP-Seq_NCS_Mouse3.10197633
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.06796824
7ETS1_20019798_ChIP-Seq_JURKAT_Human2.88543344
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.86995124
9CREB1_15753290_ChIP-ChIP_HEK293T_Human2.84753276
10ZNF274_21170338_ChIP-Seq_K562_Hela2.81860101
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.68709917
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.60648051
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.58489047
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.53191975
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.51509808
16ELK1_19687146_ChIP-ChIP_HELA_Human2.49870815
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.39594240
18VDR_22108803_ChIP-Seq_LS180_Human2.28405953
19EZH2_22144423_ChIP-Seq_EOC_Human2.15305290
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.10223346
21POU5F1_16153702_ChIP-ChIP_HESCs_Human2.09950905
22VDR_23849224_ChIP-Seq_CD4+_Human2.00467672
23FOXP3_21729870_ChIP-Seq_TREG_Human1.97445163
24IRF1_19129219_ChIP-ChIP_H3396_Human1.96285906
25TTF2_22483619_ChIP-Seq_HELA_Human1.94804092
26PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.93397948
27MYC_18940864_ChIP-ChIP_HL60_Human1.91864964
28POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.86888542
29EWS_26573619_Chip-Seq_HEK293_Human1.85605529
30XRN2_22483619_ChIP-Seq_HELA_Human1.80076600
31TP63_19390658_ChIP-ChIP_HaCaT_Human1.69858671
32ELF1_17652178_ChIP-ChIP_JURKAT_Human1.67400001
33DCP1A_22483619_ChIP-Seq_HELA_Human1.65972431
34MYC_19079543_ChIP-ChIP_MESCs_Mouse1.60900976
35MYC_19030024_ChIP-ChIP_MESCs_Mouse1.58917988
36YY1_21170310_ChIP-Seq_MESCs_Mouse1.58740516
37GABP_19822575_ChIP-Seq_HepG2_Human1.57704402
38SOX2_16153702_ChIP-ChIP_HESCs_Human1.54713972
39TP53_22573176_ChIP-Seq_HFKS_Human1.53065840
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.44799507
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.44241442
42IGF1R_20145208_ChIP-Seq_DFB_Human1.41986793
43FUS_26573619_Chip-Seq_HEK293_Human1.40762780
44TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.40338308
45MYC_18358816_ChIP-ChIP_MESCs_Mouse1.39807015
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.37952575
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.37254053
48GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.35966088
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34910826
50ETV2_25802403_ChIP-Seq_MESCs_Mouse1.32246620
51E2F1_18555785_ChIP-Seq_MESCs_Mouse1.31463539
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31263676
53EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31249440
54THAP11_20581084_ChIP-Seq_MESCs_Mouse1.31161932
55NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.30651240
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.30637222
57SRF_21415370_ChIP-Seq_HL-1_Mouse1.29943318
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28285886
59NANOG_16153702_ChIP-ChIP_HESCs_Human1.26130331
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25384112
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25161434
62PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24657669
63MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.23818906
64ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.16064730
65TAF15_26573619_Chip-Seq_HEK293_Human1.15958073
66RNF2_27304074_Chip-Seq_NSC_Mouse1.15268194
67CTBP2_25329375_ChIP-Seq_LNCAP_Human1.12585903
68NELFA_20434984_ChIP-Seq_ESCs_Mouse1.12358488
69SOX2_18555785_ChIP-Seq_MESCs_Mouse1.11105819
70NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.10289545
71NCOR_22424771_ChIP-Seq_293T_Human1.08022000
72EZH2_27304074_Chip-Seq_ESCs_Mouse1.07727874
73ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.07299841
74MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05473211
75GATA1_26923725_Chip-Seq_HPCs_Mouse1.04529800
76POU3F2_20337985_ChIP-ChIP_501MEL_Human1.02919344
77E2F7_22180533_ChIP-Seq_HELA_Human1.02871996
78P300_19829295_ChIP-Seq_ESCs_Human1.00563290
79HTT_18923047_ChIP-ChIP_STHdh_Human0.99546865
80SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.98998889
81MYCN_18555785_ChIP-Seq_MESCs_Mouse0.98048484
82ZFP57_27257070_Chip-Seq_ESCs_Mouse0.97269803
83ELK1_22589737_ChIP-Seq_MCF10A_Human0.96722403
84FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.96364128
85EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.95846505
86AR_20517297_ChIP-Seq_VCAP_Human0.93706257
87KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.92772157
88CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.92005452
89FLI1_27457419_Chip-Seq_LIVER_Mouse0.87544102
90NANOG_20526341_ChIP-Seq_ESCs_Human0.86023641
91ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85541316
92ER_23166858_ChIP-Seq_MCF-7_Human0.83139137
93NANOG_19829295_ChIP-Seq_ESCs_Human0.82466850
94SOX2_19829295_ChIP-Seq_ESCs_Human0.82466850
95CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.81634040
96HOXB4_20404135_ChIP-ChIP_EML_Mouse0.80954464
97AUTS2_25519132_ChIP-Seq_293T-REX_Human0.80822680
98CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.80175336
99NOTCH1_21737748_ChIP-Seq_TLL_Human0.79451791
100EED_16625203_ChIP-ChIP_MESCs_Mouse0.78537168

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode7.71780920
2MP0003136_yellow_coat_color3.49595916
3MP0009379_abnormal_foot_pigmentation3.45018247
4MP0002277_abnormal_respiratory_mucosa2.92392640
5MP0008789_abnormal_olfactory_epithelium2.67247820
6MP0002653_abnormal_ependyma_morphology2.65125948
7MP0006276_abnormal_autonomic_nervous2.63595338
8MP0005394_taste/olfaction_phenotype2.61770607
9MP0005499_abnormal_olfactory_system2.61770607
10MP0001529_abnormal_vocalization2.45374345
11MP0003880_abnormal_central_pattern2.42630517
12MP0001293_anophthalmia2.40578936
13MP0002102_abnormal_ear_morphology2.28882618
14MP0000049_abnormal_middle_ear2.18401884
15MP0002163_abnormal_gland_morphology2.01316154
16MP0003938_abnormal_ear_development1.99215746
17MP0000372_irregular_coat_pigmentation1.83446170
18MP0004142_abnormal_muscle_tone1.81200828
19MP0002938_white_spotting1.70176477
20MP0001485_abnormal_pinna_reflex1.65619549
21MP0008058_abnormal_DNA_repair1.56124812
22MP0005257_abnormal_intraocular_pressure1.49017686
23MP0008877_abnormal_DNA_methylation1.45933451
24MP0001286_abnormal_eye_development1.45928731
25MP0005646_abnormal_pituitary_gland1.45646889
26MP0002736_abnormal_nociception_after1.44647472
27MP0006072_abnormal_retinal_apoptosis1.40964849
28MP0003890_abnormal_embryonic-extraembry1.40114848
29MP0006035_abnormal_mitochondrial_morpho1.34038914
30MP0009697_abnormal_copulation1.32342618
31MP0003186_abnormal_redox_activity1.31256301
32MP0004133_heterotaxia1.30893038
33MP0000778_abnormal_nervous_system1.30529520
34MP0003693_abnormal_embryo_hatching1.29382123
35MP0003195_calcinosis1.29144465
36MP0010094_abnormal_chromosome_stability1.26857149
37MP0005379_endocrine/exocrine_gland_phen1.23466714
38MP0002822_catalepsy1.23381107
39MP0008995_early_reproductive_senescence1.23313459
40MP0000631_abnormal_neuroendocrine_gland1.22292649
41MP0004147_increased_porphyrin_level1.13907960
42MP0009745_abnormal_behavioral_response1.12466353
43MP0003567_abnormal_fetal_cardiomyocyte1.12412917
44MP0003786_premature_aging1.11711096
45MP0003122_maternal_imprinting1.11105877
46MP0001968_abnormal_touch/_nociception1.10742346
47MP0006036_abnormal_mitochondrial_physio1.09441241
48MP0002095_abnormal_skin_pigmentation1.07371682
49MP0002233_abnormal_nose_morphology1.06991241
50MP0003787_abnormal_imprinting1.06437601
51MP0000569_abnormal_digit_pigmentation1.06318290
52MP0008932_abnormal_embryonic_tissue1.04519395
53MP0002557_abnormal_social/conspecific_i1.03998565
54MP0004957_abnormal_blastocyst_morpholog1.03589302
55MP0003937_abnormal_limbs/digits/tail_de1.02092128
56MP0001299_abnormal_eye_distance/1.01981863
57MP0002090_abnormal_vision1.01655970
58MP0005551_abnormal_eye_electrophysiolog1.00643730
59MP0005085_abnormal_gallbladder_physiolo1.00459341
60MP0002697_abnormal_eye_size1.00038315
61MP0000026_abnormal_inner_ear0.99185880
62MP0001984_abnormal_olfaction0.98558802
63MP0001905_abnormal_dopamine_level0.96040427
64MP0008775_abnormal_heart_ventricle0.95375670
65MP0008872_abnormal_physiological_respon0.95202297
66MP0002210_abnormal_sex_determination0.94667521
67MP0002752_abnormal_somatic_nervous0.94406213
68MP0003755_abnormal_palate_morphology0.93594334
69MP0005195_abnormal_posterior_eye0.91771099
70MP0001486_abnormal_startle_reflex0.91711904
71MP0003137_abnormal_impulse_conducting0.90701326
72MP0004085_abnormal_heartbeat0.90571076
73MP0000647_abnormal_sebaceous_gland0.90387062
74MP0003121_genomic_imprinting0.90024908
75MP0002837_dystrophic_cardiac_calcinosis0.89692369
76MP0003111_abnormal_nucleus_morphology0.88838314
77MP0003077_abnormal_cell_cycle0.88753074
78MP0004145_abnormal_muscle_electrophysio0.87834468
79MP0009046_muscle_twitch0.87026684
80MP0002638_abnormal_pupillary_reflex0.86633221
81MP0002733_abnormal_thermal_nociception0.84662721
82MP0002234_abnormal_pharynx_morphology0.82959074
83MP0003119_abnormal_digestive_system0.82929062
84MP0002272_abnormal_nervous_system0.81316276
85MP0003861_abnormal_nervous_system0.79597059
86MP0002111_abnormal_tail_morphology0.79421868
87MP0002184_abnormal_innervation0.78406167
88MP0005391_vision/eye_phenotype0.77225640
89MP0005248_abnormal_Harderian_gland0.76920014
90MP0004885_abnormal_endolymph0.76897949
91MP0002160_abnormal_reproductive_system0.76560638
92MP0002282_abnormal_trachea_morphology0.75606394
93MP0005084_abnormal_gallbladder_morpholo0.75532600
94MP0000955_abnormal_spinal_cord0.75473979
95MP0000613_abnormal_salivary_gland0.75308533
96MP0001764_abnormal_homeostasis0.74478416
97MP0000653_abnormal_sex_gland0.73922379
98MP0005377_hearing/vestibular/ear_phenot0.73295276
99MP0003878_abnormal_ear_physiology0.73295276
100MP0002751_abnormal_autonomic_nervous0.72561290

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.36706571
2Septo-optic dysplasia (HP:0100842)5.10096771
3Abnormal mitochondria in muscle tissue (HP:0008316)4.78495754
4Acute encephalopathy (HP:0006846)4.69360294
5Progressive macrocephaly (HP:0004481)4.32891739
6Pancreatic fibrosis (HP:0100732)3.94563096
7Mitochondrial inheritance (HP:0001427)3.93378806
8Optic nerve hypoplasia (HP:0000609)3.66296201
9Pancreatic cysts (HP:0001737)3.66223818
10Abnormality of the labia minora (HP:0012880)3.63859667
11Maternal diabetes (HP:0009800)3.55825212
12Pendular nystagmus (HP:0012043)3.55370752
13Hepatocellular necrosis (HP:0001404)3.52561308
14Hepatic necrosis (HP:0002605)3.49641775
15Increased CSF lactate (HP:0002490)3.48194264
16Cerebral edema (HP:0002181)3.46432659
17Optic disc pallor (HP:0000543)3.45597630
18Oligodactyly (hands) (HP:0001180)3.30470064
19Reticulocytopenia (HP:0001896)3.25550856
20Aplasia/Hypoplasia of the optic nerve (HP:0008058)3.24084324
21Absent septum pellucidum (HP:0001331)3.03849941
22Supernumerary spleens (HP:0009799)2.88461953
23Abnormality of midbrain morphology (HP:0002418)2.80948610
24Molar tooth sign on MRI (HP:0002419)2.80948610
25Stenosis of the external auditory canal (HP:0000402)2.79266870
26True hermaphroditism (HP:0010459)2.77735806
27Abnormality of the septum pellucidum (HP:0007375)2.73312184
28Increased hepatocellular lipid droplets (HP:0006565)2.58442300
29Abnormal respiratory epithelium morphology (HP:0012253)2.45533832
30Abnormal respiratory motile cilium morphology (HP:0005938)2.45533832
31Leukodystrophy (HP:0002415)2.41555857
32Medial flaring of the eyebrow (HP:0010747)2.40606017
33Oligodactyly (HP:0012165)2.37657523
34Abnormal ciliary motility (HP:0012262)2.36364814
35Patellar aplasia (HP:0006443)2.32380953
36Aplasia/Hypoplasia of the spleen (HP:0010451)2.31927695
37Aplasia/Hypoplasia of the patella (HP:0006498)2.28834572
38X-linked dominant inheritance (HP:0001423)2.20173241
39Asplenia (HP:0001746)2.19592576
40Generalized aminoaciduria (HP:0002909)2.19533478
41Anophthalmia (HP:0000528)2.18550799
42Meckel diverticulum (HP:0002245)2.14133695
43Increased serum lactate (HP:0002151)2.10517471
44Sclerocornea (HP:0000647)2.10076528
45Esophageal atresia (HP:0002032)2.09521558
46Horseshoe kidney (HP:0000085)2.09457200
47Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.07915394
48Exercise intolerance (HP:0003546)2.06994037
49Lactic acidosis (HP:0003128)2.06868651
50Decreased activity of mitochondrial respiratory chain (HP:0008972)2.05692080
51Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.05692080
52Nephronophthisis (HP:0000090)2.05196887
53Cystic liver disease (HP:0006706)2.04357112
54Lipid accumulation in hepatocytes (HP:0006561)2.03841856
55Delayed CNS myelination (HP:0002188)2.00514608
56Median cleft lip (HP:0000161)1.97491575
57Abnormality of the renal cortex (HP:0011035)1.97267877
58Abnormal hair whorl (HP:0010721)1.96250317
59Abnormality of the ileum (HP:0001549)1.94928391
60Intestinal atresia (HP:0011100)1.93277344
61Increased serum pyruvate (HP:0003542)1.92721250
62Type 2 muscle fiber atrophy (HP:0003554)1.92433009
63Abnormal drinking behavior (HP:0030082)1.91298799
64Polydipsia (HP:0001959)1.91298799
65Macrocytic anemia (HP:0001972)1.89592264
66Split foot (HP:0001839)1.87945061
67Respiratory failure (HP:0002878)1.87042264
68Optic nerve coloboma (HP:0000588)1.86655648
69Absent thumb (HP:0009777)1.86653233
70Lethargy (HP:0001254)1.86181931
71Anencephaly (HP:0002323)1.86021885
72Renal Fanconi syndrome (HP:0001994)1.85206728
73Aplasia/Hypoplasia of the sacrum (HP:0008517)1.82817512
74Abnormal respiratory motile cilium physiology (HP:0012261)1.82590422
75Abnormality of the renal medulla (HP:0100957)1.82001071
76Congenital primary aphakia (HP:0007707)1.81306477
77Gait imbalance (HP:0002141)1.80823206
78Abnormality of the diencephalon (HP:0010662)1.79042337
79Methylmalonic acidemia (HP:0002912)1.77373836
80Hypoplasia of the pons (HP:0012110)1.77242873
81Occipital encephalocele (HP:0002085)1.76609528
82Preaxial hand polydactyly (HP:0001177)1.75268205
83Increased intramyocellular lipid droplets (HP:0012240)1.74474839
84Absent radius (HP:0003974)1.73950709
85Constricted visual fields (HP:0001133)1.73522695
86Triphalangeal thumb (HP:0001199)1.72458469
87Progressive cerebellar ataxia (HP:0002073)1.72327744
88Postaxial foot polydactyly (HP:0001830)1.71904146
89Aplasia involving forearm bones (HP:0009822)1.70963047
90Absent forearm bone (HP:0003953)1.70963047
91Abnormality of cells of the erythroid lineage (HP:0012130)1.70578542
92Depressed nasal ridge (HP:0000457)1.70120119
93Congenital hepatic fibrosis (HP:0002612)1.69157750
94Lissencephaly (HP:0001339)1.67345220
95Vaginal atresia (HP:0000148)1.66359636
96Aplasia/Hypoplasia of the uvula (HP:0010293)1.64909882
973-Methylglutaconic aciduria (HP:0003535)1.64676845
98Holoprosencephaly (HP:0001360)1.64584534
99Synostosis involving the elbow (HP:0003938)1.64495382
100Humeroradial synostosis (HP:0003041)1.64495382

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SRPK14.04976252
2WNK42.96272157
3CASK2.72857785
4BUB12.65760448
5PLK42.49299527
6BCKDK2.45707323
7WNK32.44158787
8MAP4K22.43427498
9NUAK12.36432715
10PINK12.28369245
11MKNK22.22240535
12ZAK2.11271900
13EPHA42.04320536
14VRK21.94807907
15TRIM281.85221484
16TIE11.82710361
17STK161.79837070
18NEK11.76679958
19GRK11.75580520
20BCR1.65788811
21DYRK21.62153916
22STK391.60199120
23MKNK11.55417053
24VRK11.45427070
25PBK1.45073386
26PLK21.40866305
27OXSR11.38927700
28LATS11.37453526
29TNIK1.36057694
30ADRBK21.26495131
31CDC71.23798008
32PLK31.20476355
33AURKA1.18048066
34AURKB1.17525142
35PLK11.15748383
36CCNB11.12996313
37TTK1.02763547
38UHMK11.02234124
39EIF2AK30.96949834
40TLK10.95913497
41NEK20.95186152
42PIM20.94506391
43DYRK30.94471544
44PRKCE0.92430239
45MAP2K70.90901012
46TAF10.90395107
47WEE10.88256585
48PRKCG0.86007631
49MAP3K40.83541857
50STK40.83490373
51MAPK130.83191054
52PRKCI0.81131192
53TNK20.80565235
54TSSK60.77913552
55CSNK1G30.77611385
56CSNK2A10.77150396
57EPHB20.76315739
58BRAF0.73078863
59CSNK1G20.65854247
60ADRBK10.64594820
61BMPR1B0.63530043
62STK30.61575248
63INSRR0.61514702
64CSNK1G10.58876582
65EIF2AK10.58166546
66NME10.58140564
67CSNK2A20.57844640
68MAP2K40.57835038
69BRSK10.57387027
70PRKCQ0.56959084
71CHEK20.53949169
72CSNK1A10.53399161
73PNCK0.53374331
74CSNK1E0.51553534
75ATR0.50321908
76MINK10.49563410
77GRK70.48657335
78STK38L0.47145548
79CDK190.45519433
80FGFR10.45501542
81ABL20.45144413
82CAMK2A0.43841062
83TAOK30.43772479
84TXK0.43040349
85PIK3CA0.42667100
86PRKG10.42570556
87CAMK2B0.42419003
88LIMK10.41428054
89SGK2230.40037204
90SGK4940.40037204
91KDR0.37531550
92ERBB30.35769864
93PRKACA0.35760686
94PRKACB0.35322422
95DAPK20.32733933
96RPS6KA50.32642537
97ATM0.32503167
98ERBB20.32004393
99OBSCN0.30899809
100CAMK2D0.30687854

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.18960123
2Oxidative phosphorylation_Homo sapiens_hsa001904.17303837
3Parkinsons disease_Homo sapiens_hsa050123.72094543
4Proteasome_Homo sapiens_hsa030503.26334906
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.24163187
6Protein export_Homo sapiens_hsa030603.20688341
7Huntingtons disease_Homo sapiens_hsa050162.62546676
8Basal transcription factors_Homo sapiens_hsa030222.50958371
9RNA polymerase_Homo sapiens_hsa030202.45389678
10Mismatch repair_Homo sapiens_hsa034302.42840323
11Alzheimers disease_Homo sapiens_hsa050102.39240285
12Homologous recombination_Homo sapiens_hsa034402.23822654
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.19548100
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.01503284
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.89033849
16DNA replication_Homo sapiens_hsa030301.84602519
17Cardiac muscle contraction_Homo sapiens_hsa042601.80867613
18Base excision repair_Homo sapiens_hsa034101.79648778
19RNA degradation_Homo sapiens_hsa030181.74820111
20Fanconi anemia pathway_Homo sapiens_hsa034601.74069584
21Spliceosome_Homo sapiens_hsa030401.67297267
22Pyrimidine metabolism_Homo sapiens_hsa002401.57156351
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.51442794
24Propanoate metabolism_Homo sapiens_hsa006401.43126746
25Non-homologous end-joining_Homo sapiens_hsa034501.40555588
26Nicotine addiction_Homo sapiens_hsa050331.33734136
27Peroxisome_Homo sapiens_hsa041461.33356502
28Folate biosynthesis_Homo sapiens_hsa007901.31701004
29Nucleotide excision repair_Homo sapiens_hsa034201.31564096
30Steroid biosynthesis_Homo sapiens_hsa001001.24707936
31RNA transport_Homo sapiens_hsa030131.22091204
32Selenocompound metabolism_Homo sapiens_hsa004501.21430680
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.15884633
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.05124945
35Sulfur metabolism_Homo sapiens_hsa009201.04941215
36Linoleic acid metabolism_Homo sapiens_hsa005911.02029005
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.01689144
38Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93204771
39Butanoate metabolism_Homo sapiens_hsa006500.91621160
40Purine metabolism_Homo sapiens_hsa002300.91531357
41Phototransduction_Homo sapiens_hsa047440.90544383
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.86570442
43Cysteine and methionine metabolism_Homo sapiens_hsa002700.83153021
44Cell cycle_Homo sapiens_hsa041100.82064895
45Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.81496644
46Metabolic pathways_Homo sapiens_hsa011000.78939173
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74764150
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74228123
49Chemical carcinogenesis_Homo sapiens_hsa052040.72287416
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72224307
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71676081
52Retinol metabolism_Homo sapiens_hsa008300.70805133
53Arginine and proline metabolism_Homo sapiens_hsa003300.70397332
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69453607
55Taste transduction_Homo sapiens_hsa047420.67871753
56Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67816298
57Caffeine metabolism_Homo sapiens_hsa002320.67522356
58Pyruvate metabolism_Homo sapiens_hsa006200.65717741
59Collecting duct acid secretion_Homo sapiens_hsa049660.63132825
60Glutathione metabolism_Homo sapiens_hsa004800.61855611
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58789079
62Maturity onset diabetes of the young_Homo sapiens_hsa049500.58647718
63One carbon pool by folate_Homo sapiens_hsa006700.58305228
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57951854
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.56365124
66Tryptophan metabolism_Homo sapiens_hsa003800.56008392
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54289083
68Regulation of autophagy_Homo sapiens_hsa041400.53904682
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52983114
70Arachidonic acid metabolism_Homo sapiens_hsa005900.51463463
71Hippo signaling pathway_Homo sapiens_hsa043900.51153260
72GABAergic synapse_Homo sapiens_hsa047270.49298638
73Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.48368577
74Olfactory transduction_Homo sapiens_hsa047400.46718746
75Fatty acid degradation_Homo sapiens_hsa000710.46611113
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.43994298
77mRNA surveillance pathway_Homo sapiens_hsa030150.42532955
78p53 signaling pathway_Homo sapiens_hsa041150.41457689
79Biosynthesis of amino acids_Homo sapiens_hsa012300.40938657
80Fat digestion and absorption_Homo sapiens_hsa049750.40835711
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40834222
82Morphine addiction_Homo sapiens_hsa050320.40500206
83Nitrogen metabolism_Homo sapiens_hsa009100.38559031
84Serotonergic synapse_Homo sapiens_hsa047260.38534912
85Glutamatergic synapse_Homo sapiens_hsa047240.37189085
86Oocyte meiosis_Homo sapiens_hsa041140.36215813
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35816916
88beta-Alanine metabolism_Homo sapiens_hsa004100.35544378
89Carbon metabolism_Homo sapiens_hsa012000.33769289
90Basal cell carcinoma_Homo sapiens_hsa052170.32110684
91Ether lipid metabolism_Homo sapiens_hsa005650.31537435
92Circadian entrainment_Homo sapiens_hsa047130.26283202
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.26277797
94Starch and sucrose metabolism_Homo sapiens_hsa005000.25517472
95Tyrosine metabolism_Homo sapiens_hsa003500.23882702
96Primary immunodeficiency_Homo sapiens_hsa053400.23680235
97Systemic lupus erythematosus_Homo sapiens_hsa053220.23366410
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.23089067
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.22504574
100Sulfur relay system_Homo sapiens_hsa041220.21534750

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