HMGB2P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1urate metabolic process (GO:0046415)6.83733280
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.40989179
3DNA deamination (GO:0045006)6.35502641
4purine-containing compound salvage (GO:0043101)5.60692489
5histone H2A acetylation (GO:0043968)5.29881769
6spermatid nucleus differentiation (GO:0007289)4.96418576
7CENP-A containing nucleosome assembly (GO:0034080)4.80119114
8rRNA modification (GO:0000154)4.60579791
9chromatin remodeling at centromere (GO:0031055)4.47887945
10cytidine metabolic process (GO:0046087)4.42152054
11cytidine catabolic process (GO:0006216)4.42152054
12cytidine deamination (GO:0009972)4.42152054
13telomere maintenance via semi-conservative replication (GO:0032201)4.31359566
14rRNA methylation (GO:0031167)4.25066875
15mitotic sister chromatid segregation (GO:0000070)4.19583318
16DNA strand elongation involved in DNA replication (GO:0006271)4.06044737
17histone exchange (GO:0043486)4.01834804
18exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.98009626
19sister chromatid segregation (GO:0000819)3.93586610
20purine nucleotide salvage (GO:0032261)3.86500533
21nucleotide-excision repair, DNA gap filling (GO:0006297)3.85563713
22DNA strand elongation (GO:0022616)3.78895785
23nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.77666463
24pyrimidine ribonucleoside catabolic process (GO:0046133)3.69302423
25DNA replication-independent nucleosome organization (GO:0034724)3.68416685
26DNA replication-independent nucleosome assembly (GO:0006336)3.68416685
27telomere maintenance via recombination (GO:0000722)3.67707697
28mitotic metaphase plate congression (GO:0007080)3.67311234
29ribosomal large subunit biogenesis (GO:0042273)3.66848135
30meiotic chromosome segregation (GO:0045132)3.64678650
31phosphate ion transport (GO:0006817)3.52243538
32attachment of spindle microtubules to kinetochore (GO:0008608)3.51605299
33regulation of dopamine metabolic process (GO:0042053)3.50988193
34regulation of catecholamine metabolic process (GO:0042069)3.50988193
35activated T cell proliferation (GO:0050798)3.50313628
36ATP synthesis coupled proton transport (GO:0015986)3.49781235
37energy coupled proton transport, down electrochemical gradient (GO:0015985)3.49781235
38purine nucleobase biosynthetic process (GO:0009113)3.46389521
39mitotic recombination (GO:0006312)3.41951023
40production of molecular mediator involved in inflammatory response (GO:0002532)3.36898606
41DNA ligation (GO:0006266)3.36883017
42kinetochore organization (GO:0051383)3.28621198
43kinetochore assembly (GO:0051382)3.27628989
44DNA topological change (GO:0006265)3.26612160
45telomere maintenance via telomere lengthening (GO:0010833)3.25909055
46mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.25552613
47regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.23139049
48somatic hypermutation of immunoglobulin genes (GO:0016446)3.18417330
49somatic diversification of immune receptors via somatic mutation (GO:0002566)3.18417330
50behavioral response to nicotine (GO:0035095)3.13344531
51nucleobase biosynthetic process (GO:0046112)3.12406231
522-deoxyribonucleotide biosynthetic process (GO:0009265)3.08437323
53deoxyribose phosphate biosynthetic process (GO:0046385)3.08437323
54metaphase plate congression (GO:0051310)3.07269758
55N-acetylglucosamine metabolic process (GO:0006044)3.03379866
56anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.03011754
57lysine metabolic process (GO:0006553)3.02263559
58lysine catabolic process (GO:0006554)3.02263559
59regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.02064712
60peptidyl-tyrosine autophosphorylation (GO:0038083)3.01228365
61deoxyribonucleotide biosynthetic process (GO:0009263)2.99993438
62negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.99919071
63establishment of protein localization to mitochondrial membrane (GO:0090151)2.96897320
64positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.95654196
65protein localization to kinetochore (GO:0034501)2.91946925
66ATP-dependent chromatin remodeling (GO:0043044)2.91248760
67mismatch repair (GO:0006298)2.90962063
68antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.90449758
69DNA replication-dependent nucleosome organization (GO:0034723)2.84638122
70DNA replication-dependent nucleosome assembly (GO:0006335)2.84638122
71positive regulation of chromosome segregation (GO:0051984)2.83211226
72organelle disassembly (GO:1903008)2.80570727
73mitotic G2 DNA damage checkpoint (GO:0007095)2.80207231
74DNA strand renaturation (GO:0000733)2.79229942
75positive regulation of megakaryocyte differentiation (GO:0045654)2.78865674
76protein homotrimerization (GO:0070207)2.76572914
77deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.74668319
78mitotic G2/M transition checkpoint (GO:0044818)2.72125181
79establishment of chromosome localization (GO:0051303)2.71941098
80positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.71031924
81positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.71031924
82positive regulation of mitotic sister chromatid separation (GO:1901970)2.71031924
83ribonucleoprotein complex disassembly (GO:0032988)2.70817010
84aminoglycoside antibiotic metabolic process (GO:0030647)2.69552211
85spindle checkpoint (GO:0031577)2.69193964
86recombinational repair (GO:0000725)2.68223659
87protein localization to chromosome (GO:0034502)2.66461602
88DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.66193776
89negative regulation of DNA-dependent DNA replication (GO:2000104)2.64875681
90regulation of exit from mitosis (GO:0007096)2.64645327
91double-strand break repair via homologous recombination (GO:0000724)2.64085858
92signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.63236554
93signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.63236554
94signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.63236554
95adenosine metabolic process (GO:0046085)2.62882432
96regulation of spindle organization (GO:0090224)2.62302267
97intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.60865227
98signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.60865227
99pseudouridine synthesis (GO:0001522)2.59600596
100DNA replication checkpoint (GO:0000076)2.59204629

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.13931461
2GATA1_22025678_ChIP-Seq_K562_Human6.69251402
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.79711422
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.38275257
5FOXM1_23109430_ChIP-Seq_U2OS_Human4.38035748
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human4.01667345
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.51932854
8ELF1_17652178_ChIP-ChIP_JURKAT_Human3.49052149
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.21985580
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.95705967
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.94454020
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.76070665
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.62452616
14ELK1_19687146_ChIP-ChIP_HELA_Human2.42279878
15VDR_23849224_ChIP-Seq_CD4+_Human2.31354596
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.23517422
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.22463933
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.21079667
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.09667218
20AR_21909140_ChIP-Seq_LNCAP_Human1.95276384
21ZNF274_21170338_ChIP-Seq_K562_Hela1.94876151
22VDR_22108803_ChIP-Seq_LS180_Human1.94733658
23CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.92690802
24IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.90529093
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.87200687
26IRF8_21731497_ChIP-ChIP_J774_Mouse1.87035470
27MYC_18940864_ChIP-ChIP_HL60_Human1.72471567
28FOXP3_21729870_ChIP-Seq_TREG_Human1.68019695
29EWS_26573619_Chip-Seq_HEK293_Human1.65121554
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.64584464
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64459051
32E2F1_21310950_ChIP-Seq_MCF-7_Human1.59149025
33IGF1R_20145208_ChIP-Seq_DFB_Human1.57607982
34CREB1_15753290_ChIP-ChIP_HEK293T_Human1.56506900
35MYC_19030024_ChIP-ChIP_MESCs_Mouse1.56370373
36IRF8_22096565_ChIP-ChIP_GC-B_Human1.53599491
37ETS1_20019798_ChIP-Seq_JURKAT_Human1.50401330
38AUTS2_25519132_ChIP-Seq_293T-REX_Human1.50268293
39ER_23166858_ChIP-Seq_MCF-7_Human1.47641467
40RBPJ_22232070_ChIP-Seq_NCS_Mouse1.45797862
41IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.45141802
42MYC_19079543_ChIP-ChIP_MESCs_Mouse1.44456464
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.41574605
44GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.37327333
45MYC_18358816_ChIP-ChIP_MESCs_Mouse1.36856055
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.36643795
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.29223988
48MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.25238913
49POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24817079
50FUS_26573619_Chip-Seq_HEK293_Human1.23240307
51NOTCH1_21737748_ChIP-Seq_TLL_Human1.22675082
52PADI4_21655091_ChIP-ChIP_MCF-7_Human1.20214263
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16511591
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.13213818
55DCP1A_22483619_ChIP-Seq_HELA_Human1.13213406
56SOX2_19829295_ChIP-Seq_ESCs_Human1.08807412
57NANOG_19829295_ChIP-Seq_ESCs_Human1.08807412
58MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.07879382
59PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07356509
60SRF_21415370_ChIP-Seq_HL-1_Mouse1.06961275
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.06909984
62E2F1_18555785_ChIP-Seq_MESCs_Mouse1.06233607
63NELFA_20434984_ChIP-Seq_ESCs_Mouse1.05012960
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04703798
65PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.04283230
66IRF1_19129219_ChIP-ChIP_H3396_Human1.03960135
67TDRD3_21172665_ChIP-Seq_MCF-7_Human1.02389538
68SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.00886288
69FOXA1_25329375_ChIP-Seq_VCAP_Human0.99789797
70FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99789797
71CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98806506
72POU5F1_16153702_ChIP-ChIP_HESCs_Human0.98628808
73FLI1_27457419_Chip-Seq_LIVER_Mouse0.98237871
74PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97609244
75PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.93661630
76GATA3_26560356_Chip-Seq_TH2_Human0.93427775
77POU3F2_20337985_ChIP-ChIP_501MEL_Human0.90897078
78EZH2_22144423_ChIP-Seq_EOC_Human0.88624496
79CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.84475267
80NCOR_22424771_ChIP-Seq_293T_Human0.82329323
81TTF2_22483619_ChIP-Seq_HELA_Human0.81754039
82TP53_22573176_ChIP-Seq_HFKS_Human0.81677464
83CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.81570483
84NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.80712180
85XRN2_22483619_ChIP-Seq_HELA_Human0.79895363
86GABP_19822575_ChIP-Seq_HepG2_Human0.77068750
87E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.76598273
88HOXB7_26014856_ChIP-Seq_BT474_Human0.75545784
89TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.75017054
90TCF4_22108803_ChIP-Seq_LS180_Human0.75001849
91HTT_18923047_ChIP-ChIP_STHdh_Human0.74622121
92HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.74038771
93UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.73986349
94STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.72628103
95MYCN_18555785_ChIP-Seq_MESCs_Mouse0.72134563
96SPI1_20517297_ChIP-Seq_HL60_Human0.70523158
97TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.69660932
98PCGF2_27294783_Chip-Seq_ESCs_Mouse0.68396339
99KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.67521362
100FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.67340343

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair4.17590022
2MP0010094_abnormal_chromosome_stability3.92281203
3MP0003111_abnormal_nucleus_morphology3.77186842
4MP0000372_irregular_coat_pigmentation3.52450377
5MP0004147_increased_porphyrin_level3.18471437
6MP0001346_abnormal_lacrimal_gland2.88343702
7MP0003693_abnormal_embryo_hatching2.87132491
8MP0009697_abnormal_copulation2.78460897
9MP0005671_abnormal_response_to2.72161973
10MP0004957_abnormal_blastocyst_morpholog2.68600437
11MP0003950_abnormal_plasma_membrane2.65665072
12MP0003077_abnormal_cell_cycle2.44193222
13MP0003878_abnormal_ear_physiology2.23290732
14MP0005377_hearing/vestibular/ear_phenot2.23290732
15MP0003806_abnormal_nucleotide_metabolis2.19013343
16MP0001348_abnormal_lacrimal_gland2.17785342
17MP0002090_abnormal_vision2.10260717
18MP0008877_abnormal_DNA_methylation1.90758839
19MP0003763_abnormal_thymus_physiology1.86976659
20MP0002938_white_spotting1.82333150
21MP0005083_abnormal_biliary_tract1.81400253
22MP0000685_abnormal_immune_system1.70169207
23MP0005645_abnormal_hypothalamus_physiol1.69270088
24MP0006072_abnormal_retinal_apoptosis1.68322949
25MP0001919_abnormal_reproductive_system1.68120033
26MP0003195_calcinosis1.56302797
27MP0005084_abnormal_gallbladder_morpholo1.56238340
28MP0002160_abnormal_reproductive_system1.54481827
29MP0002736_abnormal_nociception_after1.50109368
30MP0005551_abnormal_eye_electrophysiolog1.49709609
31MP0010234_abnormal_vibrissa_follicle1.49173062
32MP0001835_abnormal_antigen_presentation1.47987709
33MP0006035_abnormal_mitochondrial_morpho1.47741124
34MP0004808_abnormal_hematopoietic_stem1.45532831
35MP0002102_abnormal_ear_morphology1.43499833
36MP0006036_abnormal_mitochondrial_physio1.40899175
37MP0002006_tumorigenesis1.38817159
38MP0005310_abnormal_salivary_gland1.37447177
39MP0005389_reproductive_system_phenotype1.36383697
40MP0005397_hematopoietic_system_phenotyp1.35289099
41MP0001545_abnormal_hematopoietic_system1.35289099
42MP0009333_abnormal_splenocyte_physiolog1.34816610
43MP0002166_altered_tumor_susceptibility1.34259098
44MP0008057_abnormal_DNA_replication1.29283234
45MP0000015_abnormal_ear_pigmentation1.27196985
46MP0006292_abnormal_olfactory_placode1.23248478
47MP0005360_urolithiasis1.22858730
48MP0003786_premature_aging1.21249117
49MP0001929_abnormal_gametogenesis1.16646297
50MP0003252_abnormal_bile_duct1.11998734
51MP0001790_abnormal_immune_system1.09248270
52MP0005387_immune_system_phenotype1.09248270
53MP0005647_abnormal_sex_gland1.08499462
54MP0009785_altered_susceptibility_to1.04795053
55MP0001486_abnormal_startle_reflex1.04495076
56MP0005195_abnormal_posterior_eye1.02401101
57MP0008775_abnormal_heart_ventricle1.02163166
58MP0008961_abnormal_basal_metabolism1.01457618
59MP0002210_abnormal_sex_determination0.99956505
60MP0004145_abnormal_muscle_electrophysio0.94525752
61MP0003567_abnormal_fetal_cardiomyocyte0.94445731
62MP0004215_abnormal_myocardial_fiber0.93421450
63MP0003137_abnormal_impulse_conducting0.92477953
64MP0002095_abnormal_skin_pigmentation0.92219242
65MP0001145_abnormal_male_reproductive0.90213372
66MP0003880_abnormal_central_pattern0.86839267
67MP0003718_maternal_effect0.83690618
68MP0005266_abnormal_metabolism0.83060242
69MP0002405_respiratory_system_inflammati0.82242105
70MP0000653_abnormal_sex_gland0.82174304
71MP0001730_embryonic_growth_arrest0.81013815
72MP0002138_abnormal_hepatobiliary_system0.80940804
73MP0002398_abnormal_bone_marrow0.80576838
74MP0001697_abnormal_embryo_size0.79693160
75MP0001324_abnormal_eye_pigmentation0.79668835
76MP0001800_abnormal_humoral_immune0.79406851
77MP0002254_reproductive_system_inflammat0.78179304
78MP0001986_abnormal_taste_sensitivity0.78114977
79MP0005636_abnormal_mineral_homeostasis0.77174725
80MP0003698_abnormal_male_reproductive0.76798053
81MP0001819_abnormal_immune_cell0.75176843
82MP0005253_abnormal_eye_physiology0.73331217
83MP0002420_abnormal_adaptive_immunity0.73229140
84MP0003941_abnormal_skin_development0.71837542
85MP0005319_abnormal_enzyme/_coenzyme0.70876588
86MP0004019_abnormal_vitamin_homeostasis0.70621495
87MP0009379_abnormal_foot_pigmentation0.70368078
88MP0003866_abnormal_defecation0.69575481
89MP0000358_abnormal_cell_content/0.69337538
90MP0008932_abnormal_embryonic_tissue0.69301003
91MP0000516_abnormal_urinary_system0.69093485
92MP0005367_renal/urinary_system_phenotyp0.69093485
93MP0002452_abnormal_antigen_presenting0.68812039
94MP0000427_abnormal_hair_cycle0.67948506
95MP0001119_abnormal_female_reproductive0.67049775
96MP0010678_abnormal_skin_adnexa0.66602929
97MP0001764_abnormal_homeostasis0.66576912
98MP0008007_abnormal_cellular_replicative0.66444040
99MP0005025_abnormal_response_to0.66431697
100MP0002019_abnormal_tumor_incidence0.66228339

Predicted human phenotypes

RankGene SetZ-score
1Autoimmune thrombocytopenia (HP:0001973)6.69159901
2Autoimmune hemolytic anemia (HP:0001890)5.50108649
3Increased neuronal autofluorescent lipopigment (HP:0002074)5.18553648
4Visual hallucinations (HP:0002367)4.50519656
5Increased cerebral lipofuscin (HP:0011813)4.23818170
6Prostate neoplasm (HP:0100787)4.11464732
7Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)4.07061667
8Spastic diplegia (HP:0001264)3.79153859
9Parakeratosis (HP:0001036)3.75362772
10Generalized aminoaciduria (HP:0002909)3.74420348
11Abnormality of placental membranes (HP:0011409)3.68888600
12Amniotic constriction ring (HP:0009775)3.68888600
13Congenital stationary night blindness (HP:0007642)3.59688780
14Pendular nystagmus (HP:0012043)3.43557756
15Abnormality of the labia minora (HP:0012880)3.37741225
16Tetraparesis (HP:0002273)3.33203623
17Clubbing of toes (HP:0100760)3.13078548
18Testicular atrophy (HP:0000029)3.03569873
19Severe visual impairment (HP:0001141)2.88691897
20Abnormality of T cell physiology (HP:0011840)2.88444551
21Abnormality of the renal collecting system (HP:0004742)2.85578391
22Meckel diverticulum (HP:0002245)2.78567409
23Renal cortical cysts (HP:0000803)2.73216726
24Chromosomal breakage induced by crosslinking agents (HP:0003221)2.72266527
25Supernumerary spleens (HP:0009799)2.67732387
26Abnormality of the preputium (HP:0100587)2.66900549
27Agnosia (HP:0010524)2.66677772
28Aplasia/Hypoplasia of the uvula (HP:0010293)2.65774759
29Abnormality of the prostate (HP:0008775)2.65762088
30Abnormality of the ileum (HP:0001549)2.57181253
31Progressive external ophthalmoplegia (HP:0000590)2.56811634
32Acute lymphatic leukemia (HP:0006721)2.54277416
33Duplicated collecting system (HP:0000081)2.53700257
34Pancreatic cysts (HP:0001737)2.46012841
35Chromsome breakage (HP:0040012)2.45404349
36Abnormality of chromosome stability (HP:0003220)2.45387555
37Dyschromatopsia (HP:0007641)2.41674214
38Pancreatic fibrosis (HP:0100732)2.41251151
39Recurrent viral infections (HP:0004429)2.38994040
40Small intestinal stenosis (HP:0012848)2.36191652
41Duodenal stenosis (HP:0100867)2.36191652
42Hypoplastic pelvis (HP:0008839)2.32654313
43Abnormality of B cell number (HP:0010975)2.31325142
44Proximal tubulopathy (HP:0000114)2.30167121
45Conjunctival hamartoma (HP:0100780)2.27019077
46Asplenia (HP:0001746)2.25310722
47Methylmalonic acidemia (HP:0002912)2.24218038
48B lymphocytopenia (HP:0010976)2.21115057
49True hermaphroditism (HP:0010459)2.20411099
50Abnormality of the renal cortex (HP:0011035)2.17289176
51Abnormality of the proximal phalanges of the hand (HP:0009834)2.13649756
52Aplasia of the musculature (HP:0100854)2.09940175
53Abnormality of the heme biosynthetic pathway (HP:0010472)2.09390185
54Myelodysplasia (HP:0002863)2.09076072
55Abolished electroretinogram (ERG) (HP:0000550)2.06817738
56Abnormality of the phalanges of the 2nd finger (HP:0009541)2.05200590
57Aplasia/Hypoplasia of the spleen (HP:0010451)2.01259355
58Abnormality of the carotid arteries (HP:0005344)1.94168685
59Abnormality of the vitamin B12 metabolism (HP:0004341)1.92335769
60Megaloblastic anemia (HP:0001889)1.91303276
61Aplasia/Hypoplasia involving the musculature (HP:0001460)1.90277013
62Cystic hygroma (HP:0000476)1.89531501
63Squamous cell carcinoma (HP:0002860)1.89500097
64Nausea (HP:0002018)1.89073602
65Stillbirth (HP:0003826)1.88813052
66Colon cancer (HP:0003003)1.87690169
67Abnormality of the duodenum (HP:0002246)1.86529113
68Pancytopenia (HP:0001876)1.86471586
69Abnormal number of erythroid precursors (HP:0012131)1.85854139
70Absent rod-and cone-mediated responses on ERG (HP:0007688)1.85000674
71Abnormality of T cells (HP:0002843)1.84887214
72Abnormal auditory evoked potentials (HP:0006958)1.83128635
73Abnormality of cells of the erythroid lineage (HP:0012130)1.83093785
74Lymphoma (HP:0002665)1.81736708
75Aplasia/Hypoplasia of the patella (HP:0006498)1.79321903
76Attenuation of retinal blood vessels (HP:0007843)1.78801317
77Sloping forehead (HP:0000340)1.78673374
78Absent thumb (HP:0009777)1.78107186
79Abnormal lung lobation (HP:0002101)1.77341892
80Gout (HP:0001997)1.76333335
81Abnormality of purine metabolism (HP:0004352)1.74080764
82Macrocytic anemia (HP:0001972)1.72533798
83Abnormality of vitamin B metabolism (HP:0004340)1.70950855
84Melanoma (HP:0002861)1.70732467
85Hyperglycinemia (HP:0002154)1.70422934
86Central scotoma (HP:0000603)1.70280988
87Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.70139285
88Pallor (HP:0000980)1.70006308
89Patellar aplasia (HP:0006443)1.69651441
90Long clavicles (HP:0000890)1.68180280
91Neoplasm of the colon (HP:0100273)1.67704849
92Decreased central vision (HP:0007663)1.67049856
93Optic nerve hypoplasia (HP:0000609)1.66752575
94Oral leukoplakia (HP:0002745)1.65892250
95Poor speech (HP:0002465)1.65665429
96Absent radius (HP:0003974)1.65088512
97Acute encephalopathy (HP:0006846)1.63780479
98Short tibia (HP:0005736)1.63481528
99Abnormal rod and cone electroretinograms (HP:0008323)1.62735828
100Abnormality of serum amino acid levels (HP:0003112)1.61793867

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK15.80416926
2BUB15.49090846
3EIF2AK13.60201153
4MST43.22532063
5PLK42.84021433
6NUAK12.79655577
7TXK2.77812523
8VRK22.71269067
9ZAK2.51712156
10MAP4K12.42746005
11TAF12.37203379
12CDK192.32018480
13EIF2AK32.28561271
14TAOK32.19430169
15WEE12.17238213
16FRK2.02239108
17MAP3K121.86790112
18PLK31.80280743
19VRK11.70271680
20CDC71.67101752
21TTK1.63421751
22SMG11.59735853
23PLK11.53410655
24AURKA1.38192796
25NEK21.36244683
26TLK11.35735131
27ADRBK21.30889338
28CHEK21.25973225
29STK391.22045119
30STK31.20119333
31EIF2AK21.16801346
32AURKB1.11612521
33STK161.11101790
34BMPR20.97837661
35PBK0.95096308
36GRK10.92114319
37GRK50.89393047
38DYRK30.88517879
39CCNB10.87585295
40OXSR10.87447379
41BTK0.86247426
42STK100.80839920
43TNIK0.80719687
44TEC0.80660329
45MAP3K110.78187097
46IKBKB0.70086442
47PLK20.68827960
48MKNK10.66892113
49FGFR20.64741104
50PNCK0.62889017
51BRSK10.62850821
52CHEK10.60831686
53DAPK10.60006984
54CSNK2A10.59815432
55RPS6KA40.55084823
56BRAF0.54889173
57STK40.54219987
58GRK70.54210845
59ACVR1B0.51862097
60SYK0.51652921
61BMPR1B0.50763300
62BCKDK0.45911127
63ATR0.45237555
64WNK40.44865251
65PRKACB0.42304618
66DYRK20.41770076
67BRSK20.40998790
68LYN0.40017011
69TGFBR20.38806790
70WNK30.38771037
71ERBB30.37364428
72SRPK10.36733507
73CSNK2A20.36439463
74PASK0.35706646
75STK110.35372422
76MUSK0.34428092
77ATM0.34188083
78NME20.33782809
79CSNK1A10.32003863
80MKNK20.31659105
81INSRR0.30114634
82CDK10.29446157
83AKT30.29205454
84KDR0.26326623
85MAP4K20.26210104
86PIK3CG0.24722048
87PRKCD0.24021793
88PRKACA0.22962915
89TSSK60.22935707
90LATS10.21376547
91TRIM280.20921232
92MAP3K140.20023126
93RPS6KB10.19708698
94MAPKAPK50.19460524
95ITK0.18460284
96LCK0.18451030
97CAMK2D0.18400891
98CAMK2G0.18229570
99ADRBK10.17897014
100DAPK30.17496518

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.59687098
2Proteasome_Homo sapiens_hsa030504.30554990
3DNA replication_Homo sapiens_hsa030304.05821552
4Homologous recombination_Homo sapiens_hsa034403.89199478
5Fanconi anemia pathway_Homo sapiens_hsa034602.76340772
6Ribosome_Homo sapiens_hsa030102.59346513
7Nucleotide excision repair_Homo sapiens_hsa034202.56139754
8One carbon pool by folate_Homo sapiens_hsa006702.39412687
9Spliceosome_Homo sapiens_hsa030402.05816507
10Protein export_Homo sapiens_hsa030602.03444950
11Oxidative phosphorylation_Homo sapiens_hsa001901.92686643
12Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.79117548
13Parkinsons disease_Homo sapiens_hsa050121.77424480
14Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.68438293
15Pyrimidine metabolism_Homo sapiens_hsa002401.65259512
16RNA degradation_Homo sapiens_hsa030181.62618760
17Asthma_Homo sapiens_hsa053101.61816377
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.58403678
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.58272432
20Cell cycle_Homo sapiens_hsa041101.56625014
21Selenocompound metabolism_Homo sapiens_hsa004501.53612939
22Propanoate metabolism_Homo sapiens_hsa006401.51299541
23Basal transcription factors_Homo sapiens_hsa030221.51297258
24Primary immunodeficiency_Homo sapiens_hsa053401.47413270
25Pentose and glucuronate interconversions_Homo sapiens_hsa000401.44947847
26Base excision repair_Homo sapiens_hsa034101.28832179
27Antigen processing and presentation_Homo sapiens_hsa046121.26977883
28Steroid biosynthesis_Homo sapiens_hsa001001.24740276
29Phototransduction_Homo sapiens_hsa047441.23332962
30Graft-versus-host disease_Homo sapiens_hsa053321.21195612
31Systemic lupus erythematosus_Homo sapiens_hsa053221.19610765
32RNA transport_Homo sapiens_hsa030131.18323096
33RNA polymerase_Homo sapiens_hsa030201.17814329
34Allograft rejection_Homo sapiens_hsa053301.17244399
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.12555991
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12018810
37Renin-angiotensin system_Homo sapiens_hsa046141.09688932
38Purine metabolism_Homo sapiens_hsa002301.08886488
39Non-homologous end-joining_Homo sapiens_hsa034501.08805133
40Autoimmune thyroid disease_Homo sapiens_hsa053201.07381306
41Huntingtons disease_Homo sapiens_hsa050161.06571992
42Drug metabolism - other enzymes_Homo sapiens_hsa009831.02426563
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.99470966
44Alzheimers disease_Homo sapiens_hsa050100.99303622
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.98925405
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.98520517
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.95198783
48Butanoate metabolism_Homo sapiens_hsa006500.94891457
49Tryptophan metabolism_Homo sapiens_hsa003800.94228900
50Linoleic acid metabolism_Homo sapiens_hsa005910.90439647
51Type I diabetes mellitus_Homo sapiens_hsa049400.88692026
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87498501
53mRNA surveillance pathway_Homo sapiens_hsa030150.83041343
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82961953
55Ether lipid metabolism_Homo sapiens_hsa005650.82453512
56Glutathione metabolism_Homo sapiens_hsa004800.82145922
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81738456
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80996594
59p53 signaling pathway_Homo sapiens_hsa041150.78675759
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77894955
61Chemical carcinogenesis_Homo sapiens_hsa052040.73873613
62Taste transduction_Homo sapiens_hsa047420.72831018
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.71717451
64Cyanoamino acid metabolism_Homo sapiens_hsa004600.70182905
65Sulfur metabolism_Homo sapiens_hsa009200.67668608
66Retinol metabolism_Homo sapiens_hsa008300.64770161
67Cardiac muscle contraction_Homo sapiens_hsa042600.64285669
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63500577
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60749532
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.60659268
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60441123
72Nitrogen metabolism_Homo sapiens_hsa009100.59961369
73Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59102259
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.57431971
75Caffeine metabolism_Homo sapiens_hsa002320.56041125
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.55844755
77Metabolic pathways_Homo sapiens_hsa011000.50596405
78Hematopoietic cell lineage_Homo sapiens_hsa046400.50357027
792-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.50326564
80Olfactory transduction_Homo sapiens_hsa047400.47488158
81Alcoholism_Homo sapiens_hsa050340.42917292
82African trypanosomiasis_Homo sapiens_hsa051430.41266346
83HTLV-I infection_Homo sapiens_hsa051660.40588984
84Oocyte meiosis_Homo sapiens_hsa041140.40259812
85Mineral absorption_Homo sapiens_hsa049780.37506883
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36964753
87Rheumatoid arthritis_Homo sapiens_hsa053230.36432064
88Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36295528
89Arachidonic acid metabolism_Homo sapiens_hsa005900.35622472
90Fatty acid elongation_Homo sapiens_hsa000620.35115856
91Vitamin B6 metabolism_Homo sapiens_hsa007500.34559404
92Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34047246
93Fatty acid degradation_Homo sapiens_hsa000710.33274313
94Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32626761
95Herpes simplex infection_Homo sapiens_hsa051680.32267954
96Starch and sucrose metabolism_Homo sapiens_hsa005000.28562926
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27898590
98RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.26147942
99Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.23499810
100Pyruvate metabolism_Homo sapiens_hsa006200.23420969

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