ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.85049434
2	regulation of somitogenesis (GO:0014807)	5.14154968
3	maturation of 5.8S rRNA (GO:0000460)	4.15144220
4	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.11605847
5	positive regulation of triglyceride biosynthetic process (GO:0010867)	4.08386952
6	positive regulation of embryonic development (GO:0040019)	3.79804757
7	somite development (GO:0061053)	3.70081704
8	kynurenine metabolic process (GO:0070189)	3.60604808
9	L-fucose catabolic process (GO:0042355)	3.60236257
10	fucose catabolic process (GO:0019317)	3.60236257
11	L-fucose metabolic process (GO:0042354)	3.60236257
12	indolalkylamine metabolic process (GO:0006586)	3.58434295
13	protein-cofactor linkage (GO:0018065)	3.52965730
14	platelet dense granule organization (GO:0060155)	3.52392821
15	tryptophan catabolic process (GO:0006569)	3.51195752
16	indole-containing compound catabolic process (GO:0042436)	3.51195752
17	indolalkylamine catabolic process (GO:0046218)	3.51195752
18	negative regulation of mast cell activation (GO:0033004)	3.46880067
19	cellular ketone body metabolic process (GO:0046950)	3.44239050
20	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.43949257
21	regulation of triglyceride biosynthetic process (GO:0010866)	3.29160068
22	nephron epithelium morphogenesis (GO:0072088)	3.28884247
23	nephron tubule morphogenesis (GO:0072078)	3.28884247
24	piRNA metabolic process (GO:0034587)	3.26568170
25	water-soluble vitamin biosynthetic process (GO:0042364)	3.23903868
26	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.20969525
27	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.20969525
28	NADH dehydrogenase complex assembly (GO:0010257)	3.20969525
29	tryptophan metabolic process (GO:0006568)	3.19660164
30	gamma-aminobutyric acid transport (GO:0015812)	3.18671296
31	ubiquinone biosynthetic process (GO:0006744)	3.14772421
32	neuronal action potential (GO:0019228)	3.13434081
33	reflex (GO:0060004)	3.11523599
34	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.09750015
35	ketone body metabolic process (GO:1902224)	3.09395242
36	DNA deamination (GO:0045006)	3.05813477
37	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.04254379
38	ATP synthesis coupled proton transport (GO:0015986)	3.04254379
39	regulation of mitotic spindle checkpoint (GO:1903504)	3.02014877
40	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.02014877
41	ubiquinone metabolic process (GO:0006743)	2.99658866
42	mitochondrial respiratory chain complex assembly (GO:0033108)	2.99280025
43	negative regulation of telomere maintenance (GO:0032205)	2.98122254
44	reciprocal DNA recombination (GO:0035825)	2.96831446
45	reciprocal meiotic recombination (GO:0007131)	2.96831446
46	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.95342416
47	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.95207381
48	protein complex biogenesis (GO:0070271)	2.95114784
49	neuron fate determination (GO:0048664)	2.92495176
50	respiratory chain complex IV assembly (GO:0008535)	2.91887591
51	epithelial cilium movement (GO:0003351)	2.91351405
52	male meiosis I (GO:0007141)	2.89763316
53	nonmotile primary cilium assembly (GO:0035058)	2.88976524
54	indole-containing compound metabolic process (GO:0042430)	2.85300867
55	autophagic vacuole fusion (GO:0000046)	2.83109730
56	detection of light stimulus involved in visual perception (GO:0050908)	2.81954716
57	detection of light stimulus involved in sensory perception (GO:0050962)	2.81954716
58	primary amino compound metabolic process (GO:1901160)	2.81237328
59	response to pheromone (GO:0019236)	2.81115528
60	synaptic transmission, cholinergic (GO:0007271)	2.81114151
61	regulation of hexokinase activity (GO:1903299)	2.81107584
62	regulation of glucokinase activity (GO:0033131)	2.81107584
63	cornea development in camera-type eye (GO:0061303)	2.77559182
64	protein polyglutamylation (GO:0018095)	2.73004511
65	spinal cord motor neuron differentiation (GO:0021522)	2.71699839
66	regulation of action potential (GO:0098900)	2.71542620
67	ribosomal large subunit biogenesis (GO:0042273)	2.70866882
68	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.69498394
69	preassembly of GPI anchor in ER membrane (GO:0016254)	2.66617848
70	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.65831447
71	positive regulation of action potential (GO:0045760)	2.65097952
72	basic amino acid transport (GO:0015802)	2.63094404
73	sulfation (GO:0051923)	2.61651985
74	transmission of nerve impulse (GO:0019226)	2.59387621
75	kidney morphogenesis (GO:0060993)	2.59233026
76	amine catabolic process (GO:0009310)	2.58519423
77	cellular biogenic amine catabolic process (GO:0042402)	2.58519423
78	behavioral response to ethanol (GO:0048149)	2.55799393
79	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.55103128
80	positive regulation of fatty acid transport (GO:2000193)	2.53887979
81	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.52408792
82	axoneme assembly (GO:0035082)	2.52020611
83	dopaminergic neuron differentiation (GO:0071542)	2.51184107
84	regulation of mesoderm development (GO:2000380)	2.50558256
85	rhodopsin mediated signaling pathway (GO:0016056)	2.50055436
86	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.49189485
87	neuron cell-cell adhesion (GO:0007158)	2.48042679
88	neuronal stem cell maintenance (GO:0097150)	2.47172905
89	quinone biosynthetic process (GO:1901663)	2.46527052
90	neural tube formation (GO:0001841)	2.46022705
91	regulation of neurotransmitter uptake (GO:0051580)	2.45444791
92	cellular response to ATP (GO:0071318)	2.44833639
93	organelle membrane fusion (GO:0090174)	2.44140580
94	GPI anchor metabolic process (GO:0006505)	2.43858933
95	mannosylation (GO:0097502)	2.43548304
96	fucosylation (GO:0036065)	2.43283383
97	DNA methylation involved in gamete generation (GO:0043046)	2.42968064
98	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.42847064
99	positive regulation of sodium ion transmembrane transport (GO:1902307)	2.42446914
100	intracellular protein transmembrane import (GO:0044743)	2.41946179

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.18311889
2	VDR_22108803_ChIP-Seq_LS180_Human	3.66891528
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.05333453
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.69098718
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.55016031
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.39112056
7	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.33011190
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.27474668
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.24475518
10	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.20795264
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.16680630
12	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.15086241
13	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.04230048
14	IGF1R_20145208_ChIP-Seq_DFB_Human	2.00654155
15	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.99813977
16	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.96480893
17	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.89723842
18	FUS_26573619_Chip-Seq_HEK293_Human	1.88907768
19	P300_19829295_ChIP-Seq_ESCs_Human	1.87694410
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.83971447
21	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.81653445
22	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.80752053
23	EWS_26573619_Chip-Seq_HEK293_Human	1.77481562
24	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.76760242
25	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.73875894
26	MYC_18940864_ChIP-ChIP_HL60_Human	1.72776192
27	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.71514438
28	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.64579564
29	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.63844453
30	IRF1_19129219_ChIP-ChIP_H3396_Human	1.61824367
31	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.58279582
32	TAF15_26573619_Chip-Seq_HEK293_Human	1.57491408
33	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.57160279
34	BCAT_22108803_ChIP-Seq_LS180_Human	1.50763680
35	REST_21632747_ChIP-Seq_MESCs_Mouse	1.49816697
36	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.48378148
37	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.47921386
38	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.46733946
39	TP53_22573176_ChIP-Seq_HFKS_Human	1.46212064
40	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.45123597
41	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.44509216
42	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.42216640
43	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.41073906
44	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.38929170
45	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.38929170
46	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.37001767
47	RNF2_27304074_Chip-Seq_NSC_Mouse	1.36740168
48	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.36386507
49	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.34982439
50	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.32776128
51	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.31009511
52	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.30940360
53	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.28801446
54	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.28411515
55	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.28293375
56	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.28221651
57	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.28221651
58	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.25914202
59	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.23325436
60	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.22343656
61	AR_25329375_ChIP-Seq_VCAP_Human	1.22159167
62	SMAD4_21799915_ChIP-Seq_A2780_Human	1.22024506
63	STAT3_23295773_ChIP-Seq_U87_Human	1.21714267
64	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.20541267
65	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.20263017
66	TCF4_22108803_ChIP-Seq_LS180_Human	1.18380934
67	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.16791110
68	CBP_20019798_ChIP-Seq_JUKART_Human	1.16791110
69	SOX2_19829295_ChIP-Seq_ESCs_Human	1.16625085
70	NANOG_19829295_ChIP-Seq_ESCs_Human	1.16625085
71	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.14990589
72	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.13584068
73	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.13526838
74	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.13519383
75	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.12557726
76	NCOR_22424771_ChIP-Seq_293T_Human	1.12182178
77	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.11270699
78	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.10883270
79	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.09476340
80	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.09139211
81	TCF4_23295773_ChIP-Seq_U87_Human	1.08431004
82	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.08046942
83	ELK1_19687146_ChIP-ChIP_HELA_Human	1.07409219
84	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.07012916
85	RUNX2_22187159_ChIP-Seq_PCA_Human	1.06460402
86	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.06360582
87	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.06051608
88	HOXB7_26014856_ChIP-Seq_BT474_Human	1.04064966
89	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.03451273
90	AR_20517297_ChIP-Seq_VCAP_Human	1.03068069
91	ERA_21632823_ChIP-Seq_H3396_Human	1.00055252
92	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.99911422
93	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.99649845
94	MYC_19829295_ChIP-Seq_ESCs_Human	0.99366730
95	VDR_23849224_ChIP-Seq_CD4+_Human	0.98438843
96	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.98119341
97	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.97827276
98	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.96132932
99	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.95800163
100	P53_22387025_ChIP-Seq_ESCs_Mouse	0.95689733

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	3.59482504
2	MP0002102_abnormal_ear_morphology	3.02366868
3	MP0002653_abnormal_ependyma_morphology	2.52552409
4	MP0008875_abnormal_xenobiotic_pharmacok	2.39572713
5	MP0002876_abnormal_thyroid_physiology	2.37176578
6	MP0008877_abnormal_DNA_methylation	2.34836811
7	MP0005551_abnormal_eye_electrophysiolog	2.30520857
8	MP0004133_heterotaxia	2.17437385
9	MP0002638_abnormal_pupillary_reflex	2.07621922
10	MP0002277_abnormal_respiratory_mucosa	2.00279584
11	MP0002837_dystrophic_cardiac_calcinosis	1.99408478
12	MP0005084_abnormal_gallbladder_morpholo	1.99094435
13	MP0009745_abnormal_behavioral_response	1.95740906
14	MP0003011_delayed_dark_adaptation	1.93916435
15	MP0003195_calcinosis	1.93163854
16	MP0000569_abnormal_digit_pigmentation	1.92991156
17	MP0001968_abnormal_touch/_nociception	1.91021154
18	MP0001986_abnormal_taste_sensitivity	1.86870923
19	MP0001485_abnormal_pinna_reflex	1.85232856
20	MP0008872_abnormal_physiological_respon	1.84586414
21	MP0003880_abnormal_central_pattern	1.77155118
22	MP0005646_abnormal_pituitary_gland	1.77054551
23	MP0006292_abnormal_olfactory_placode	1.76813176
24	MP0004885_abnormal_endolymph	1.75530341
25	MP0002272_abnormal_nervous_system	1.74278596
26	MP0000631_abnormal_neuroendocrine_gland	1.73579080
27	MP0006072_abnormal_retinal_apoptosis	1.72909255
28	MP0003646_muscle_fatigue	1.71933564
29	MP0004142_abnormal_muscle_tone	1.70615417
30	MP0002736_abnormal_nociception_after	1.69460487
31	MP0002938_white_spotting	1.67796666
32	MP0002735_abnormal_chemical_nociception	1.66764736
33	MP0003283_abnormal_digestive_organ	1.62513138
34	MP0005174_abnormal_tail_pigmentation	1.52117685
35	MP0001905_abnormal_dopamine_level	1.51492925
36	MP0002160_abnormal_reproductive_system	1.48516851
37	MP0002064_seizures	1.47065379
38	MP0001486_abnormal_startle_reflex	1.43813905
39	MP0005253_abnormal_eye_physiology	1.43178453
40	MP0005645_abnormal_hypothalamus_physiol	1.42837316
41	MP0002733_abnormal_thermal_nociception	1.40706944
42	MP0004742_abnormal_vestibular_system	1.39820331
43	MP0002928_abnormal_bile_duct	1.38936869
44	MP0006276_abnormal_autonomic_nervous	1.37053877
45	MP0002572_abnormal_emotion/affect_behav	1.36938488
46	MP0009046_muscle_twitch	1.34533546
47	MP0000372_irregular_coat_pigmentation	1.34133626
48	MP0001970_abnormal_pain_threshold	1.31543125
49	MP0001529_abnormal_vocalization	1.30123408
50	MP0001919_abnormal_reproductive_system	1.29744117
51	MP0001346_abnormal_lacrimal_gland	1.25764050
52	MP0003787_abnormal_imprinting	1.25730369
53	MP0005085_abnormal_gallbladder_physiolo	1.23487178
54	MP0004043_abnormal_pH_regulation	1.23162297
55	MP0005389_reproductive_system_phenotype	1.19754963
56	MP0001984_abnormal_olfaction	1.19095502
57	MP0004145_abnormal_muscle_electrophysio	1.18730715
58	MP0000026_abnormal_inner_ear	1.17747914
59	MP0002734_abnormal_mechanical_nocicepti	1.17300149
60	MP0001501_abnormal_sleep_pattern	1.14514936
61	MP0005423_abnormal_somatic_nervous	1.13975310
62	MP0001324_abnormal_eye_pigmentation	1.13770626
63	MP0002557_abnormal_social/conspecific_i	1.11804816
64	MP0000427_abnormal_hair_cycle	1.11775942
65	MP0005195_abnormal_posterior_eye	1.10900726
66	MP0002067_abnormal_sensory_capabilities	1.08754970
67	MP0002063_abnormal_learning/memory/cond	1.07743984
68	MP0002095_abnormal_skin_pigmentation	1.06656908
69	MP0000383_abnormal_hair_follicle	1.05220059
70	MP0004147_increased_porphyrin_level	1.05133521
71	MP0002234_abnormal_pharynx_morphology	1.04182782
72	MP0002751_abnormal_autonomic_nervous	1.04152793
73	MP0000778_abnormal_nervous_system	1.03257687
74	MP0003635_abnormal_synaptic_transmissio	1.02226917
75	MP0010386_abnormal_urinary_bladder	1.00854997
76	MP0001177_atelectasis	0.99812539
77	MP0004215_abnormal_myocardial_fiber	0.97291033
78	MP0000566_synostosis	0.96337418
79	MP0003878_abnormal_ear_physiology	0.96210457
80	MP0005377_hearing/vestibular/ear_phenot	0.96210457
81	MP0002282_abnormal_trachea_morphology	0.96168389
82	MP0000015_abnormal_ear_pigmentation	0.94249857
83	MP0003137_abnormal_impulse_conducting	0.92736036
84	MP0003879_abnormal_hair_cell	0.92592245
85	MP0001293_anophthalmia	0.92274236
86	MP0002752_abnormal_somatic_nervous	0.92071575
87	MP0004924_abnormal_behavior	0.91141694
88	MP0005386_behavior/neurological_phenoty	0.91141694
89	MP0003119_abnormal_digestive_system	0.89868628
90	MP0003938_abnormal_ear_development	0.87345098
91	MP0008775_abnormal_heart_ventricle	0.86356580
92	MP0001963_abnormal_hearing_physiology	0.86314415
93	MP0002229_neurodegeneration	0.85117677
94	MP0005075_abnormal_melanosome_morpholog	0.84417781
95	MP0001502_abnormal_circadian_rhythm	0.82790944
96	MP0008789_abnormal_olfactory_epithelium	0.81814112
97	MP0000955_abnormal_spinal_cord	0.80692325
98	MP0005167_abnormal_blood-brain_barrier	0.78583145
99	MP0002184_abnormal_innervation	0.77992203
100	MP0000647_abnormal_sebaceous_gland	0.75271583

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Type II lissencephaly (HP:0007260)	4.81112720
2	Pancreatic cysts (HP:0001737)	4.59865598
3	True hermaphroditism (HP:0010459)	4.30527640
4	Pancreatic fibrosis (HP:0100732)	4.19636438
5	Molar tooth sign on MRI (HP:0002419)	3.84505585
6	Abnormality of midbrain morphology (HP:0002418)	3.84505585
7	Cerebellar dysplasia (HP:0007033)	3.83874448
8	Congenital stationary night blindness (HP:0007642)	3.79953543
9	Nephronophthisis (HP:0000090)	3.45219478
10	Congenital, generalized hypertrichosis (HP:0004540)	3.23021404
11	Retinal dysplasia (HP:0007973)	3.19419761
12	Pendular nystagmus (HP:0012043)	3.19243831
13	Male pseudohermaphroditism (HP:0000037)	3.18342555
14	Abolished electroretinogram (ERG) (HP:0000550)	3.08063769
15	Sclerocornea (HP:0000647)	2.90829223
16	Cystic liver disease (HP:0006706)	2.90321789
17	Abnormality of the renal medulla (HP:0100957)	2.89471711
18	Birth length less than 3rd percentile (HP:0003561)	2.82613626
19	Medial flaring of the eyebrow (HP:0010747)	2.80583683
20	Abnormality of the renal cortex (HP:0011035)	2.71488428
21	Anterior segment dysgenesis (HP:0007700)	2.57549446
22	Lissencephaly (HP:0001339)	2.55480716
23	Abnormal drinking behavior (HP:0030082)	2.53711525
24	Polydipsia (HP:0001959)	2.53711525
25	Abnormal rod and cone electroretinograms (HP:0008323)	2.53589536
26	Large for gestational age (HP:0001520)	2.52680951
27	Progressive inability to walk (HP:0002505)	2.52497889
28	Acute necrotizing encephalopathy (HP:0006965)	2.47475361
29	Inability to walk (HP:0002540)	2.46159412
30	Furrowed tongue (HP:0000221)	2.44957121
31	Attenuation of retinal blood vessels (HP:0007843)	2.41554628
32	Tubular atrophy (HP:0000092)	2.38635000
33	Hyperalaninemia (HP:0003348)	2.35199213
34	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.35199213
35	Abnormality of alanine metabolism (HP:0010916)	2.35199213
36	Increased corneal curvature (HP:0100692)	2.33971064
37	Keratoconus (HP:0000563)	2.33971064
38	Bilateral microphthalmos (HP:0007633)	2.33630619
39	Chronic hepatic failure (HP:0100626)	2.32635423
40	Mitochondrial inheritance (HP:0001427)	2.28905585
41	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.28008932
42	Neonatal respiratory distress (HP:0002643)	2.24614865
43	Gait imbalance (HP:0002141)	2.24145305
44	Anophthalmia (HP:0000528)	2.20175833
45	Anencephaly (HP:0002323)	2.19450328
46	Patellar aplasia (HP:0006443)	2.19305353
47	Hyperventilation (HP:0002883)	2.17005519
48	Acute encephalopathy (HP:0006846)	2.16198632
49	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.15401820
50	Progressive macrocephaly (HP:0004481)	2.14958465
51	Congenital primary aphakia (HP:0007707)	2.13365144
52	Increased CSF lactate (HP:0002490)	2.12668568
53	Aplasia/Hypoplasia of the patella (HP:0006498)	2.12629625
54	Absent thumb (HP:0009777)	2.11666952
55	Congenital hepatic fibrosis (HP:0002612)	2.07640509
56	Abnormal mitochondria in muscle tissue (HP:0008316)	2.04561695
57	Chorioretinal atrophy (HP:0000533)	2.03926543
58	Polyuria (HP:0000103)	2.03258180
59	Decreased central vision (HP:0007663)	2.03039965
60	Septo-optic dysplasia (HP:0100842)	2.00920951
61	Rib fusion (HP:0000902)	2.00680405
62	3-Methylglutaconic aciduria (HP:0003535)	2.00522015
63	Optic nerve hypoplasia (HP:0000609)	2.00356138
64	Hypomagnesemia (HP:0002917)	1.99614899
65	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.98053638
66	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.96108551
67	Absent/shortened dynein arms (HP:0200106)	1.96108551
68	Renal cortical cysts (HP:0000803)	1.94283779
69	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.93677716
70	Nephrogenic diabetes insipidus (HP:0009806)	1.92674852
71	Abnormality of the pons (HP:0007361)	1.90928288
72	Methylmalonic acidemia (HP:0002912)	1.90530482
73	Optic disc pallor (HP:0000543)	1.89649668
74	Hypoplasia of the pons (HP:0012110)	1.88245812
75	Broad-based gait (HP:0002136)	1.88173961
76	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.86189405
77	Bile duct proliferation (HP:0001408)	1.85595132
78	Abnormal biliary tract physiology (HP:0012439)	1.85595132
79	Hyperglycinuria (HP:0003108)	1.84646879
80	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.84177479
81	Postaxial foot polydactyly (HP:0001830)	1.83896704
82	Genital tract atresia (HP:0001827)	1.83836769
83	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.83693261
84	Decreased circulating renin level (HP:0003351)	1.83618636
85	Vaginal atresia (HP:0000148)	1.83267315
86	Dandy-Walker malformation (HP:0001305)	1.82696574
87	Hypothermia (HP:0002045)	1.82454287
88	Lipid accumulation in hepatocytes (HP:0006561)	1.81462130
89	Concave nail (HP:0001598)	1.77798803
90	Hepatocellular necrosis (HP:0001404)	1.74783900
91	Increased hepatocellular lipid droplets (HP:0006565)	1.74408940
92	Occipital encephalocele (HP:0002085)	1.74076399
93	Congenital sensorineural hearing impairment (HP:0008527)	1.73840326
94	Short tibia (HP:0005736)	1.73253942
95	Agitation (HP:0000713)	1.73221657
96	Progressive cerebellar ataxia (HP:0002073)	1.73121410
97	Gastrointestinal atresia (HP:0002589)	1.71930628
98	Severe muscular hypotonia (HP:0006829)	1.71512329
99	Methylmalonic aciduria (HP:0012120)	1.70985028
100	Abnormal number of erythroid precursors (HP:0012131)	1.69270407

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	INSRR	4.35594443
2	PNCK	3.61054542
3	FRK	3.46797600
4	ADRBK2	3.32726980
5	WNK3	3.25510055
6	BMPR1B	2.73938415
7	WNK4	2.46528545
8	MAP4K2	2.44186798
9	GRK1	2.35578614
10	PINK1	2.15320942
11	TXK	2.14520197
12	ZAK	2.07551983
13	MAPK15	2.04607403
14	TAOK3	1.97434429
15	CAMKK2	1.95093036
16	TLK1	1.89922713
17	WEE1	1.85327546
18	CASK	1.83911119
19	MAPK13	1.77197791
20	NUAK1	1.70384072
21	ACVR1B	1.63699198
22	MARK1	1.49826498
23	OXSR1	1.49772002
24	BRSK2	1.45951863
25	STK39	1.44256044
26	MKNK2	1.41893351
27	DAPK2	1.40890729
28	TNIK	1.29733477
29	MAP3K4	1.23923210
30	DYRK2	1.16616467
31	PRKCG	1.15634666
32	PAK3	1.12949142
33	ADRBK1	1.05607111
34	VRK1	1.04735967
35	CDK19	1.04659350
36	NTRK2	0.89418158
37	MUSK	0.88956873
38	TIE1	0.88656627
39	TSSK6	0.87576833
40	TGFBR1	0.86984561
41	PHKG1	0.83201159
42	PHKG2	0.83201159
43	NME1	0.83128277
44	MAP2K7	0.81973809
45	NEK2	0.78889716
46	CAMKK1	0.76852354
47	BCKDK	0.76304142
48	PRKCE	0.74408002
49	MKNK1	0.72275130
50	NTRK3	0.72166390
51	MAP2K6	0.71281388
52	IRAK1	0.69840785
53	STK16	0.68838306
54	CCNB1	0.62879487
55	TRIM28	0.62414097
56	PRKCI	0.60100720
57	RPS6KA5	0.58724940
58	PLK2	0.58490763
59	PRKCQ	0.57760076
60	CHEK2	0.55901076
61	CSNK1G2	0.54972858
62	STK3	0.54398939
63	PLK3	0.53246224
64	IKBKB	0.52822810
65	MAPKAPK3	0.52609895
66	CAMK2A	0.51390315
67	KIT	0.51056239
68	CHUK	0.51004699
69	PRKACA	0.49742001
70	PIK3CA	0.49199971
71	PASK	0.47115416
72	STK11	0.45194791
73	PTK2B	0.44338355
74	FGFR2	0.43963737
75	PLK4	0.43936828
76	MAPKAPK5	0.42905653
77	EPHA4	0.41399163
78	PKN1	0.39782844
79	TEC	0.39621248
80	CSNK1G3	0.39374545
81	CSNK1G1	0.38521801
82	CSNK1A1	0.36331307
83	VRK2	0.35832157
84	STK38L	0.35399849
85	GRK7	0.34864076
86	DYRK3	0.33391419
87	OBSCN	0.32473733
88	CAMK1	0.32309579
89	MAP2K2	0.32166313
90	MST4	0.32149499
91	FLT3	0.30391932
92	PRKCA	0.30177643
93	ITK	0.29034741
94	MAP2K4	0.28719625
95	EPHA3	0.28434297
96	PLK1	0.25595847
97	CSNK1D	0.25569979
98	PAK6	0.24791287
99	IGF1R	0.24499407
100	RPS6KA4	0.24033974

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	2.88090453
2	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.68945770
3	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.64292742
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.59701144
5	Linoleic acid metabolism_Homo sapiens_hsa00591	2.54514386
6	Phototransduction_Homo sapiens_hsa04744	2.51703783
7	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.47650471
8	Homologous recombination_Homo sapiens_hsa03440	2.34943534
9	Parkinsons disease_Homo sapiens_hsa05012	2.34830056
10	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.31279282
11	Nitrogen metabolism_Homo sapiens_hsa00910	2.26288106
12	Nicotine addiction_Homo sapiens_hsa05033	2.17391190
13	Butanoate metabolism_Homo sapiens_hsa00650	2.06549167
14	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.05677579
15	Caffeine metabolism_Homo sapiens_hsa00232	2.00392399
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.98769061
17	Selenocompound metabolism_Homo sapiens_hsa00450	1.96642342
18	Protein export_Homo sapiens_hsa03060	1.92994616
19	Tryptophan metabolism_Homo sapiens_hsa00380	1.92809853
20	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.87225050
21	Basal transcription factors_Homo sapiens_hsa03022	1.82852488
22	Fanconi anemia pathway_Homo sapiens_hsa03460	1.72473706
23	Cardiac muscle contraction_Homo sapiens_hsa04260	1.63881011
24	RNA polymerase_Homo sapiens_hsa03020	1.61118484
25	Ether lipid metabolism_Homo sapiens_hsa00565	1.53901637
26	Huntingtons disease_Homo sapiens_hsa05016	1.48168975
27	Taste transduction_Homo sapiens_hsa04742	1.47581874
28	Alzheimers disease_Homo sapiens_hsa05010	1.45958640
29	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.35465097
30	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.34767268
31	Ribosome_Homo sapiens_hsa03010	1.27586336
32	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.23932763
33	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.17840590
34	Morphine addiction_Homo sapiens_hsa05032	1.15348384
35	ABC transporters_Homo sapiens_hsa02010	1.11515200
36	RNA degradation_Homo sapiens_hsa03018	1.05055692
37	One carbon pool by folate_Homo sapiens_hsa00670	1.04857231
38	Peroxisome_Homo sapiens_hsa04146	1.03468648
39	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.02778804
40	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.02640907
41	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.02381299
42	Propanoate metabolism_Homo sapiens_hsa00640	1.01321030
43	Regulation of autophagy_Homo sapiens_hsa04140	0.99807463
44	Chemical carcinogenesis_Homo sapiens_hsa05204	0.98220598
45	Serotonergic synapse_Homo sapiens_hsa04726	0.96239001
46	Fat digestion and absorption_Homo sapiens_hsa04975	0.95140524
47	Olfactory transduction_Homo sapiens_hsa04740	0.92585543
48	Proteasome_Homo sapiens_hsa03050	0.92430982
49	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.91757294
50	Histidine metabolism_Homo sapiens_hsa00340	0.91472674
51	Retinol metabolism_Homo sapiens_hsa00830	0.89322922
52	Fatty acid degradation_Homo sapiens_hsa00071	0.88743140
53	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.88294798
54	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.86963126
55	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.86522943
56	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.84127408
57	GABAergic synapse_Homo sapiens_hsa04727	0.83695815
58	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.82197390
59	Glutamatergic synapse_Homo sapiens_hsa04724	0.79075864
60	Glycerolipid metabolism_Homo sapiens_hsa00561	0.76909413
61	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.73351205
62	Insulin secretion_Homo sapiens_hsa04911	0.73022823
63	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.72966303
64	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.72820255
65	Circadian entrainment_Homo sapiens_hsa04713	0.71643694
66	beta-Alanine metabolism_Homo sapiens_hsa00410	0.70499558
67	Collecting duct acid secretion_Homo sapiens_hsa04966	0.67350628
68	Steroid biosynthesis_Homo sapiens_hsa00100	0.64271916
69	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.64142528
70	Asthma_Homo sapiens_hsa05310	0.62855445
71	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.61423534
72	Metabolic pathways_Homo sapiens_hsa01100	0.61130842
73	Mineral absorption_Homo sapiens_hsa04978	0.61115438
74	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.60996637
75	Purine metabolism_Homo sapiens_hsa00230	0.57289395
76	Primary immunodeficiency_Homo sapiens_hsa05340	0.56075999
77	Salivary secretion_Homo sapiens_hsa04970	0.53521538
78	Pyrimidine metabolism_Homo sapiens_hsa00240	0.51899826
79	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.51456615
80	Calcium signaling pathway_Homo sapiens_hsa04020	0.51454916
81	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.50705229
82	Sulfur relay system_Homo sapiens_hsa04122	0.49555261
83	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.48330923
84	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.47670197
85	Sulfur metabolism_Homo sapiens_hsa00920	0.47585571
86	Cocaine addiction_Homo sapiens_hsa05030	0.46784887
87	Amphetamine addiction_Homo sapiens_hsa05031	0.45157661
88	Basal cell carcinoma_Homo sapiens_hsa05217	0.44606856
89	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.44500137
90	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.41544221
91	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.40844939
92	Type I diabetes mellitus_Homo sapiens_hsa04940	0.38607822
93	Dopaminergic synapse_Homo sapiens_hsa04728	0.35992441
94	Fatty acid metabolism_Homo sapiens_hsa01212	0.35002834
95	Circadian rhythm_Homo sapiens_hsa04710	0.34215947
96	Tyrosine metabolism_Homo sapiens_hsa00350	0.31417909
97	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.30132320
98	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.29622888
99	Nucleotide excision repair_Homo sapiens_hsa03420	0.27749573
100	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.24084271

HMGB1P39

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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