HMGB1P39

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.85049434
2regulation of somitogenesis (GO:0014807)5.14154968
3maturation of 5.8S rRNA (GO:0000460)4.15144220
4detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.11605847
5positive regulation of triglyceride biosynthetic process (GO:0010867)4.08386952
6positive regulation of embryonic development (GO:0040019)3.79804757
7somite development (GO:0061053)3.70081704
8kynurenine metabolic process (GO:0070189)3.60604808
9L-fucose catabolic process (GO:0042355)3.60236257
10fucose catabolic process (GO:0019317)3.60236257
11L-fucose metabolic process (GO:0042354)3.60236257
12indolalkylamine metabolic process (GO:0006586)3.58434295
13protein-cofactor linkage (GO:0018065)3.52965730
14platelet dense granule organization (GO:0060155)3.52392821
15tryptophan catabolic process (GO:0006569)3.51195752
16indole-containing compound catabolic process (GO:0042436)3.51195752
17indolalkylamine catabolic process (GO:0046218)3.51195752
18negative regulation of mast cell activation (GO:0033004)3.46880067
19cellular ketone body metabolic process (GO:0046950)3.44239050
20establishment of protein localization to mitochondrial membrane (GO:0090151)3.43949257
21regulation of triglyceride biosynthetic process (GO:0010866)3.29160068
22nephron epithelium morphogenesis (GO:0072088)3.28884247
23nephron tubule morphogenesis (GO:0072078)3.28884247
24piRNA metabolic process (GO:0034587)3.26568170
25water-soluble vitamin biosynthetic process (GO:0042364)3.23903868
26mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.20969525
27mitochondrial respiratory chain complex I assembly (GO:0032981)3.20969525
28NADH dehydrogenase complex assembly (GO:0010257)3.20969525
29tryptophan metabolic process (GO:0006568)3.19660164
30gamma-aminobutyric acid transport (GO:0015812)3.18671296
31ubiquinone biosynthetic process (GO:0006744)3.14772421
32neuronal action potential (GO:0019228)3.13434081
33reflex (GO:0060004)3.11523599
34epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.09750015
35ketone body metabolic process (GO:1902224)3.09395242
36DNA deamination (GO:0045006)3.05813477
37energy coupled proton transport, down electrochemical gradient (GO:0015985)3.04254379
38ATP synthesis coupled proton transport (GO:0015986)3.04254379
39regulation of mitotic spindle checkpoint (GO:1903504)3.02014877
40regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.02014877
41ubiquinone metabolic process (GO:0006743)2.99658866
42mitochondrial respiratory chain complex assembly (GO:0033108)2.99280025
43negative regulation of telomere maintenance (GO:0032205)2.98122254
44reciprocal DNA recombination (GO:0035825)2.96831446
45reciprocal meiotic recombination (GO:0007131)2.96831446
46mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.95342416
47negative regulation of synaptic transmission, GABAergic (GO:0032229)2.95207381
48protein complex biogenesis (GO:0070271)2.95114784
49neuron fate determination (GO:0048664)2.92495176
50respiratory chain complex IV assembly (GO:0008535)2.91887591
51epithelial cilium movement (GO:0003351)2.91351405
52male meiosis I (GO:0007141)2.89763316
53nonmotile primary cilium assembly (GO:0035058)2.88976524
54indole-containing compound metabolic process (GO:0042430)2.85300867
55autophagic vacuole fusion (GO:0000046)2.83109730
56detection of light stimulus involved in visual perception (GO:0050908)2.81954716
57detection of light stimulus involved in sensory perception (GO:0050962)2.81954716
58primary amino compound metabolic process (GO:1901160)2.81237328
59response to pheromone (GO:0019236)2.81115528
60synaptic transmission, cholinergic (GO:0007271)2.81114151
61regulation of hexokinase activity (GO:1903299)2.81107584
62regulation of glucokinase activity (GO:0033131)2.81107584
63cornea development in camera-type eye (GO:0061303)2.77559182
64protein polyglutamylation (GO:0018095)2.73004511
65spinal cord motor neuron differentiation (GO:0021522)2.71699839
66regulation of action potential (GO:0098900)2.71542620
67ribosomal large subunit biogenesis (GO:0042273)2.70866882
68positive regulation of oligodendrocyte differentiation (GO:0048714)2.69498394
69preassembly of GPI anchor in ER membrane (GO:0016254)2.66617848
70mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.65831447
71positive regulation of action potential (GO:0045760)2.65097952
72basic amino acid transport (GO:0015802)2.63094404
73sulfation (GO:0051923)2.61651985
74transmission of nerve impulse (GO:0019226)2.59387621
75kidney morphogenesis (GO:0060993)2.59233026
76amine catabolic process (GO:0009310)2.58519423
77cellular biogenic amine catabolic process (GO:0042402)2.58519423
78behavioral response to ethanol (GO:0048149)2.55799393
79regulation of rhodopsin mediated signaling pathway (GO:0022400)2.55103128
80positive regulation of fatty acid transport (GO:2000193)2.53887979
81positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.52408792
82axoneme assembly (GO:0035082)2.52020611
83dopaminergic neuron differentiation (GO:0071542)2.51184107
84regulation of mesoderm development (GO:2000380)2.50558256
85rhodopsin mediated signaling pathway (GO:0016056)2.50055436
86G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.49189485
87neuron cell-cell adhesion (GO:0007158)2.48042679
88neuronal stem cell maintenance (GO:0097150)2.47172905
89quinone biosynthetic process (GO:1901663)2.46527052
90neural tube formation (GO:0001841)2.46022705
91regulation of neurotransmitter uptake (GO:0051580)2.45444791
92cellular response to ATP (GO:0071318)2.44833639
93organelle membrane fusion (GO:0090174)2.44140580
94GPI anchor metabolic process (GO:0006505)2.43858933
95mannosylation (GO:0097502)2.43548304
96fucosylation (GO:0036065)2.43283383
97DNA methylation involved in gamete generation (GO:0043046)2.42968064
98detection of mechanical stimulus involved in sensory perception (GO:0050974)2.42847064
99positive regulation of sodium ion transmembrane transport (GO:1902307)2.42446914
100intracellular protein transmembrane import (GO:0044743)2.41946179

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.18311889
2VDR_22108803_ChIP-Seq_LS180_Human3.66891528
3EZH2_22144423_ChIP-Seq_EOC_Human3.05333453
4GBX2_23144817_ChIP-Seq_PC3_Human2.69098718
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.55016031
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.39112056
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.33011190
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.27474668
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.24475518
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.20795264
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.16680630
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.15086241
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.04230048
14IGF1R_20145208_ChIP-Seq_DFB_Human2.00654155
15BMI1_23680149_ChIP-Seq_NPCS_Mouse1.99813977
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.96480893
17EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.89723842
18FUS_26573619_Chip-Seq_HEK293_Human1.88907768
19P300_19829295_ChIP-Seq_ESCs_Human1.87694410
20ER_23166858_ChIP-Seq_MCF-7_Human1.83971447
21PCGF2_27294783_Chip-Seq_ESCs_Mouse1.81653445
22CBX2_27304074_Chip-Seq_ESCs_Mouse1.80752053
23EWS_26573619_Chip-Seq_HEK293_Human1.77481562
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.76760242
25NOTCH1_21737748_ChIP-Seq_TLL_Human1.73875894
26MYC_18940864_ChIP-ChIP_HL60_Human1.72776192
27MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.71514438
28GABP_17652178_ChIP-ChIP_JURKAT_Human1.64579564
29SALL1_21062744_ChIP-ChIP_HESCs_Human1.63844453
30IRF1_19129219_ChIP-ChIP_H3396_Human1.61824367
31EST1_17652178_ChIP-ChIP_JURKAT_Human1.58279582
32TAF15_26573619_Chip-Seq_HEK293_Human1.57491408
33PCGF2_27294783_Chip-Seq_NPCs_Mouse1.57160279
34BCAT_22108803_ChIP-Seq_LS180_Human1.50763680
35REST_21632747_ChIP-Seq_MESCs_Mouse1.49816697
36RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48378148
37KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.47921386
38CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.46733946
39TP53_22573176_ChIP-Seq_HFKS_Human1.46212064
40E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.45123597
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44509216
42EED_16625203_ChIP-ChIP_MESCs_Mouse1.42216640
43UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.41073906
44TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38929170
45POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.38929170
46GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.37001767
47RNF2_27304074_Chip-Seq_NSC_Mouse1.36740168
48EZH2_27304074_Chip-Seq_ESCs_Mouse1.36386507
49AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.34982439
50POU5F1_16153702_ChIP-ChIP_HESCs_Human1.32776128
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31009511
52JARID2_20064375_ChIP-Seq_MESCs_Mouse1.30940360
53NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28801446
54GATA3_21878914_ChIP-Seq_MCF-7_Human1.28411515
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28293375
56FOXA1_25329375_ChIP-Seq_VCAP_Human1.28221651
57FOXA1_27270436_Chip-Seq_PROSTATE_Human1.28221651
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25914202
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23325436
60SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.22343656
61AR_25329375_ChIP-Seq_VCAP_Human1.22159167
62SMAD4_21799915_ChIP-Seq_A2780_Human1.22024506
63STAT3_23295773_ChIP-Seq_U87_Human1.21714267
64NFE2_27457419_Chip-Seq_LIVER_Mouse1.20541267
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.20263017
66TCF4_22108803_ChIP-Seq_LS180_Human1.18380934
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16791110
68CBP_20019798_ChIP-Seq_JUKART_Human1.16791110
69SOX2_19829295_ChIP-Seq_ESCs_Human1.16625085
70NANOG_19829295_ChIP-Seq_ESCs_Human1.16625085
71SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.14990589
72EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.13584068
73EZH2_27294783_Chip-Seq_ESCs_Mouse1.13526838
74MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13519383
75FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12557726
76NCOR_22424771_ChIP-Seq_293T_Human1.12182178
77SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.11270699
78SMAD3_21741376_ChIP-Seq_EPCs_Human1.10883270
79CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09476340
80SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09139211
81TCF4_23295773_ChIP-Seq_U87_Human1.08431004
82JARID2_20075857_ChIP-Seq_MESCs_Mouse1.08046942
83ELK1_19687146_ChIP-ChIP_HELA_Human1.07409219
84REST_18959480_ChIP-ChIP_MESCs_Mouse1.07012916
85RUNX2_22187159_ChIP-Seq_PCA_Human1.06460402
86EZH2_27294783_Chip-Seq_NPCs_Mouse1.06360582
87SMAD4_21741376_ChIP-Seq_EPCs_Human1.06051608
88HOXB7_26014856_ChIP-Seq_BT474_Human1.04064966
89SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.03451273
90AR_20517297_ChIP-Seq_VCAP_Human1.03068069
91ERA_21632823_ChIP-Seq_H3396_Human1.00055252
92KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99911422
93EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99649845
94MYC_19829295_ChIP-Seq_ESCs_Human0.99366730
95VDR_23849224_ChIP-Seq_CD4+_Human0.98438843
96TP63_19390658_ChIP-ChIP_HaCaT_Human0.98119341
97ETV2_25802403_ChIP-Seq_MESCs_Mouse0.97827276
98CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.96132932
99RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.95800163
100P53_22387025_ChIP-Seq_ESCs_Mouse0.95689733

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color3.59482504
2MP0002102_abnormal_ear_morphology3.02366868
3MP0002653_abnormal_ependyma_morphology2.52552409
4MP0008875_abnormal_xenobiotic_pharmacok2.39572713
5MP0002876_abnormal_thyroid_physiology2.37176578
6MP0008877_abnormal_DNA_methylation2.34836811
7MP0005551_abnormal_eye_electrophysiolog2.30520857
8MP0004133_heterotaxia2.17437385
9MP0002638_abnormal_pupillary_reflex2.07621922
10MP0002277_abnormal_respiratory_mucosa2.00279584
11MP0002837_dystrophic_cardiac_calcinosis1.99408478
12MP0005084_abnormal_gallbladder_morpholo1.99094435
13MP0009745_abnormal_behavioral_response1.95740906
14MP0003011_delayed_dark_adaptation1.93916435
15MP0003195_calcinosis1.93163854
16MP0000569_abnormal_digit_pigmentation1.92991156
17MP0001968_abnormal_touch/_nociception1.91021154
18MP0001986_abnormal_taste_sensitivity1.86870923
19MP0001485_abnormal_pinna_reflex1.85232856
20MP0008872_abnormal_physiological_respon1.84586414
21MP0003880_abnormal_central_pattern1.77155118
22MP0005646_abnormal_pituitary_gland1.77054551
23MP0006292_abnormal_olfactory_placode1.76813176
24MP0004885_abnormal_endolymph1.75530341
25MP0002272_abnormal_nervous_system1.74278596
26MP0000631_abnormal_neuroendocrine_gland1.73579080
27MP0006072_abnormal_retinal_apoptosis1.72909255
28MP0003646_muscle_fatigue1.71933564
29MP0004142_abnormal_muscle_tone1.70615417
30MP0002736_abnormal_nociception_after1.69460487
31MP0002938_white_spotting1.67796666
32MP0002735_abnormal_chemical_nociception1.66764736
33MP0003283_abnormal_digestive_organ1.62513138
34MP0005174_abnormal_tail_pigmentation1.52117685
35MP0001905_abnormal_dopamine_level1.51492925
36MP0002160_abnormal_reproductive_system1.48516851
37MP0002064_seizures1.47065379
38MP0001486_abnormal_startle_reflex1.43813905
39MP0005253_abnormal_eye_physiology1.43178453
40MP0005645_abnormal_hypothalamus_physiol1.42837316
41MP0002733_abnormal_thermal_nociception1.40706944
42MP0004742_abnormal_vestibular_system1.39820331
43MP0002928_abnormal_bile_duct1.38936869
44MP0006276_abnormal_autonomic_nervous1.37053877
45MP0002572_abnormal_emotion/affect_behav1.36938488
46MP0009046_muscle_twitch1.34533546
47MP0000372_irregular_coat_pigmentation1.34133626
48MP0001970_abnormal_pain_threshold1.31543125
49MP0001529_abnormal_vocalization1.30123408
50MP0001919_abnormal_reproductive_system1.29744117
51MP0001346_abnormal_lacrimal_gland1.25764050
52MP0003787_abnormal_imprinting1.25730369
53MP0005085_abnormal_gallbladder_physiolo1.23487178
54MP0004043_abnormal_pH_regulation1.23162297
55MP0005389_reproductive_system_phenotype1.19754963
56MP0001984_abnormal_olfaction1.19095502
57MP0004145_abnormal_muscle_electrophysio1.18730715
58MP0000026_abnormal_inner_ear1.17747914
59MP0002734_abnormal_mechanical_nocicepti1.17300149
60MP0001501_abnormal_sleep_pattern1.14514936
61MP0005423_abnormal_somatic_nervous1.13975310
62MP0001324_abnormal_eye_pigmentation1.13770626
63MP0002557_abnormal_social/conspecific_i1.11804816
64MP0000427_abnormal_hair_cycle1.11775942
65MP0005195_abnormal_posterior_eye1.10900726
66MP0002067_abnormal_sensory_capabilities1.08754970
67MP0002063_abnormal_learning/memory/cond1.07743984
68MP0002095_abnormal_skin_pigmentation1.06656908
69MP0000383_abnormal_hair_follicle1.05220059
70MP0004147_increased_porphyrin_level1.05133521
71MP0002234_abnormal_pharynx_morphology1.04182782
72MP0002751_abnormal_autonomic_nervous1.04152793
73MP0000778_abnormal_nervous_system1.03257687
74MP0003635_abnormal_synaptic_transmissio1.02226917
75MP0010386_abnormal_urinary_bladder1.00854997
76MP0001177_atelectasis0.99812539
77MP0004215_abnormal_myocardial_fiber0.97291033
78MP0000566_synostosis0.96337418
79MP0003878_abnormal_ear_physiology0.96210457
80MP0005377_hearing/vestibular/ear_phenot0.96210457
81MP0002282_abnormal_trachea_morphology0.96168389
82MP0000015_abnormal_ear_pigmentation0.94249857
83MP0003137_abnormal_impulse_conducting0.92736036
84MP0003879_abnormal_hair_cell0.92592245
85MP0001293_anophthalmia0.92274236
86MP0002752_abnormal_somatic_nervous0.92071575
87MP0004924_abnormal_behavior0.91141694
88MP0005386_behavior/neurological_phenoty0.91141694
89MP0003119_abnormal_digestive_system0.89868628
90MP0003938_abnormal_ear_development0.87345098
91MP0008775_abnormal_heart_ventricle0.86356580
92MP0001963_abnormal_hearing_physiology0.86314415
93MP0002229_neurodegeneration0.85117677
94MP0005075_abnormal_melanosome_morpholog0.84417781
95MP0001502_abnormal_circadian_rhythm0.82790944
96MP0008789_abnormal_olfactory_epithelium0.81814112
97MP0000955_abnormal_spinal_cord0.80692325
98MP0005167_abnormal_blood-brain_barrier0.78583145
99MP0002184_abnormal_innervation0.77992203
100MP0000647_abnormal_sebaceous_gland0.75271583

Predicted human phenotypes

RankGene SetZ-score
1Type II lissencephaly (HP:0007260)4.81112720
2Pancreatic cysts (HP:0001737)4.59865598
3True hermaphroditism (HP:0010459)4.30527640
4Pancreatic fibrosis (HP:0100732)4.19636438
5Molar tooth sign on MRI (HP:0002419)3.84505585
6Abnormality of midbrain morphology (HP:0002418)3.84505585
7Cerebellar dysplasia (HP:0007033)3.83874448
8Congenital stationary night blindness (HP:0007642)3.79953543
9Nephronophthisis (HP:0000090)3.45219478
10Congenital, generalized hypertrichosis (HP:0004540)3.23021404
11Retinal dysplasia (HP:0007973)3.19419761
12Pendular nystagmus (HP:0012043)3.19243831
13Male pseudohermaphroditism (HP:0000037)3.18342555
14Abolished electroretinogram (ERG) (HP:0000550)3.08063769
15Sclerocornea (HP:0000647)2.90829223
16Cystic liver disease (HP:0006706)2.90321789
17Abnormality of the renal medulla (HP:0100957)2.89471711
18Birth length less than 3rd percentile (HP:0003561)2.82613626
19Medial flaring of the eyebrow (HP:0010747)2.80583683
20Abnormality of the renal cortex (HP:0011035)2.71488428
21Anterior segment dysgenesis (HP:0007700)2.57549446
22Lissencephaly (HP:0001339)2.55480716
23Abnormal drinking behavior (HP:0030082)2.53711525
24Polydipsia (HP:0001959)2.53711525
25Abnormal rod and cone electroretinograms (HP:0008323)2.53589536
26Large for gestational age (HP:0001520)2.52680951
27Progressive inability to walk (HP:0002505)2.52497889
28Acute necrotizing encephalopathy (HP:0006965)2.47475361
29Inability to walk (HP:0002540)2.46159412
30Furrowed tongue (HP:0000221)2.44957121
31Attenuation of retinal blood vessels (HP:0007843)2.41554628
32Tubular atrophy (HP:0000092)2.38635000
33Hyperalaninemia (HP:0003348)2.35199213
34Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.35199213
35Abnormality of alanine metabolism (HP:0010916)2.35199213
36Increased corneal curvature (HP:0100692)2.33971064
37Keratoconus (HP:0000563)2.33971064
38Bilateral microphthalmos (HP:0007633)2.33630619
39Chronic hepatic failure (HP:0100626)2.32635423
40Mitochondrial inheritance (HP:0001427)2.28905585
41Absent rod-and cone-mediated responses on ERG (HP:0007688)2.28008932
42Neonatal respiratory distress (HP:0002643)2.24614865
43Gait imbalance (HP:0002141)2.24145305
44Anophthalmia (HP:0000528)2.20175833
45Anencephaly (HP:0002323)2.19450328
46Patellar aplasia (HP:0006443)2.19305353
47Hyperventilation (HP:0002883)2.17005519
48Acute encephalopathy (HP:0006846)2.16198632
49Aplasia/Hypoplasia of the tongue (HP:0010295)2.15401820
50Progressive macrocephaly (HP:0004481)2.14958465
51Congenital primary aphakia (HP:0007707)2.13365144
52Increased CSF lactate (HP:0002490)2.12668568
53Aplasia/Hypoplasia of the patella (HP:0006498)2.12629625
54Absent thumb (HP:0009777)2.11666952
55Congenital hepatic fibrosis (HP:0002612)2.07640509
56Abnormal mitochondria in muscle tissue (HP:0008316)2.04561695
57Chorioretinal atrophy (HP:0000533)2.03926543
58Polyuria (HP:0000103)2.03258180
59Decreased central vision (HP:0007663)2.03039965
60Septo-optic dysplasia (HP:0100842)2.00920951
61Rib fusion (HP:0000902)2.00680405
623-Methylglutaconic aciduria (HP:0003535)2.00522015
63Optic nerve hypoplasia (HP:0000609)2.00356138
64Hypomagnesemia (HP:0002917)1.99614899
65Aplasia/Hypoplasia of the tibia (HP:0005772)1.98053638
66Dynein arm defect of respiratory motile cilia (HP:0012255)1.96108551
67Absent/shortened dynein arms (HP:0200106)1.96108551
68Renal cortical cysts (HP:0000803)1.94283779
69Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.93677716
70Nephrogenic diabetes insipidus (HP:0009806)1.92674852
71Abnormality of the pons (HP:0007361)1.90928288
72Methylmalonic acidemia (HP:0002912)1.90530482
73Optic disc pallor (HP:0000543)1.89649668
74Hypoplasia of the pons (HP:0012110)1.88245812
75Broad-based gait (HP:0002136)1.88173961
76Aplasia/Hypoplasia of the uvula (HP:0010293)1.86189405
77Bile duct proliferation (HP:0001408)1.85595132
78Abnormal biliary tract physiology (HP:0012439)1.85595132
79Hyperglycinuria (HP:0003108)1.84646879
80Decreased electroretinogram (ERG) amplitude (HP:0000654)1.84177479
81Postaxial foot polydactyly (HP:0001830)1.83896704
82Genital tract atresia (HP:0001827)1.83836769
83Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.83693261
84Decreased circulating renin level (HP:0003351)1.83618636
85Vaginal atresia (HP:0000148)1.83267315
86Dandy-Walker malformation (HP:0001305)1.82696574
87Hypothermia (HP:0002045)1.82454287
88Lipid accumulation in hepatocytes (HP:0006561)1.81462130
89Concave nail (HP:0001598)1.77798803
90Hepatocellular necrosis (HP:0001404)1.74783900
91Increased hepatocellular lipid droplets (HP:0006565)1.74408940
92Occipital encephalocele (HP:0002085)1.74076399
93Congenital sensorineural hearing impairment (HP:0008527)1.73840326
94Short tibia (HP:0005736)1.73253942
95Agitation (HP:0000713)1.73221657
96Progressive cerebellar ataxia (HP:0002073)1.73121410
97Gastrointestinal atresia (HP:0002589)1.71930628
98Severe muscular hypotonia (HP:0006829)1.71512329
99Methylmalonic aciduria (HP:0012120)1.70985028
100Abnormal number of erythroid precursors (HP:0012131)1.69270407

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR4.35594443
2PNCK3.61054542
3FRK3.46797600
4ADRBK23.32726980
5WNK33.25510055
6BMPR1B2.73938415
7WNK42.46528545
8MAP4K22.44186798
9GRK12.35578614
10PINK12.15320942
11TXK2.14520197
12ZAK2.07551983
13MAPK152.04607403
14TAOK31.97434429
15CAMKK21.95093036
16TLK11.89922713
17WEE11.85327546
18CASK1.83911119
19MAPK131.77197791
20NUAK11.70384072
21ACVR1B1.63699198
22MARK11.49826498
23OXSR11.49772002
24BRSK21.45951863
25STK391.44256044
26MKNK21.41893351
27DAPK21.40890729
28TNIK1.29733477
29MAP3K41.23923210
30DYRK21.16616467
31PRKCG1.15634666
32PAK31.12949142
33ADRBK11.05607111
34VRK11.04735967
35CDK191.04659350
36NTRK20.89418158
37MUSK0.88956873
38TIE10.88656627
39TSSK60.87576833
40TGFBR10.86984561
41PHKG10.83201159
42PHKG20.83201159
43NME10.83128277
44MAP2K70.81973809
45NEK20.78889716
46CAMKK10.76852354
47BCKDK0.76304142
48PRKCE0.74408002
49MKNK10.72275130
50NTRK30.72166390
51MAP2K60.71281388
52IRAK10.69840785
53STK160.68838306
54CCNB10.62879487
55TRIM280.62414097
56PRKCI0.60100720
57RPS6KA50.58724940
58PLK20.58490763
59PRKCQ0.57760076
60CHEK20.55901076
61CSNK1G20.54972858
62STK30.54398939
63PLK30.53246224
64IKBKB0.52822810
65MAPKAPK30.52609895
66CAMK2A0.51390315
67KIT0.51056239
68CHUK0.51004699
69PRKACA0.49742001
70PIK3CA0.49199971
71PASK0.47115416
72STK110.45194791
73PTK2B0.44338355
74FGFR20.43963737
75PLK40.43936828
76MAPKAPK50.42905653
77EPHA40.41399163
78PKN10.39782844
79TEC0.39621248
80CSNK1G30.39374545
81CSNK1G10.38521801
82CSNK1A10.36331307
83VRK20.35832157
84STK38L0.35399849
85GRK70.34864076
86DYRK30.33391419
87OBSCN0.32473733
88CAMK10.32309579
89MAP2K20.32166313
90MST40.32149499
91FLT30.30391932
92PRKCA0.30177643
93ITK0.29034741
94MAP2K40.28719625
95EPHA30.28434297
96PLK10.25595847
97CSNK1D0.25569979
98PAK60.24791287
99IGF1R0.24499407
100RPS6KA40.24033974

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001902.88090453
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.68945770
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.64292742
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.59701144
5Linoleic acid metabolism_Homo sapiens_hsa005912.54514386
6Phototransduction_Homo sapiens_hsa047442.51703783
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.47650471
8Homologous recombination_Homo sapiens_hsa034402.34943534
9Parkinsons disease_Homo sapiens_hsa050122.34830056
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.31279282
11Nitrogen metabolism_Homo sapiens_hsa009102.26288106
12Nicotine addiction_Homo sapiens_hsa050332.17391190
13Butanoate metabolism_Homo sapiens_hsa006502.06549167
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.05677579
15Caffeine metabolism_Homo sapiens_hsa002322.00392399
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.98769061
17Selenocompound metabolism_Homo sapiens_hsa004501.96642342
18Protein export_Homo sapiens_hsa030601.92994616
19Tryptophan metabolism_Homo sapiens_hsa003801.92809853
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.87225050
21Basal transcription factors_Homo sapiens_hsa030221.82852488
22Fanconi anemia pathway_Homo sapiens_hsa034601.72473706
23Cardiac muscle contraction_Homo sapiens_hsa042601.63881011
24RNA polymerase_Homo sapiens_hsa030201.61118484
25Ether lipid metabolism_Homo sapiens_hsa005651.53901637
26Huntingtons disease_Homo sapiens_hsa050161.48168975
27Taste transduction_Homo sapiens_hsa047421.47581874
28Alzheimers disease_Homo sapiens_hsa050101.45958640
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.35465097
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.34767268
31Ribosome_Homo sapiens_hsa030101.27586336
32Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.23932763
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17840590
34Morphine addiction_Homo sapiens_hsa050321.15348384
35ABC transporters_Homo sapiens_hsa020101.11515200
36RNA degradation_Homo sapiens_hsa030181.05055692
37One carbon pool by folate_Homo sapiens_hsa006701.04857231
38Peroxisome_Homo sapiens_hsa041461.03468648
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02778804
40SNARE interactions in vesicular transport_Homo sapiens_hsa041301.02640907
41Intestinal immune network for IgA production_Homo sapiens_hsa046721.02381299
42Propanoate metabolism_Homo sapiens_hsa006401.01321030
43Regulation of autophagy_Homo sapiens_hsa041400.99807463
44Chemical carcinogenesis_Homo sapiens_hsa052040.98220598
45Serotonergic synapse_Homo sapiens_hsa047260.96239001
46Fat digestion and absorption_Homo sapiens_hsa049750.95140524
47Olfactory transduction_Homo sapiens_hsa047400.92585543
48Proteasome_Homo sapiens_hsa030500.92430982
49Arachidonic acid metabolism_Homo sapiens_hsa005900.91757294
50Histidine metabolism_Homo sapiens_hsa003400.91472674
51Retinol metabolism_Homo sapiens_hsa008300.89322922
52Fatty acid degradation_Homo sapiens_hsa000710.88743140
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.88294798
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86963126
55Steroid hormone biosynthesis_Homo sapiens_hsa001400.86522943
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.84127408
57GABAergic synapse_Homo sapiens_hsa047270.83695815
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.82197390
59Glutamatergic synapse_Homo sapiens_hsa047240.79075864
60Glycerolipid metabolism_Homo sapiens_hsa005610.76909413
61Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.73351205
62Insulin secretion_Homo sapiens_hsa049110.73022823
63Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.72966303
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72820255
65Circadian entrainment_Homo sapiens_hsa047130.71643694
66beta-Alanine metabolism_Homo sapiens_hsa004100.70499558
67Collecting duct acid secretion_Homo sapiens_hsa049660.67350628
68Steroid biosynthesis_Homo sapiens_hsa001000.64271916
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64142528
70Asthma_Homo sapiens_hsa053100.62855445
71Ovarian steroidogenesis_Homo sapiens_hsa049130.61423534
72Metabolic pathways_Homo sapiens_hsa011000.61130842
73Mineral absorption_Homo sapiens_hsa049780.61115438
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60996637
75Purine metabolism_Homo sapiens_hsa002300.57289395
76Primary immunodeficiency_Homo sapiens_hsa053400.56075999
77Salivary secretion_Homo sapiens_hsa049700.53521538
78Pyrimidine metabolism_Homo sapiens_hsa002400.51899826
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51456615
80Calcium signaling pathway_Homo sapiens_hsa040200.51454916
81Hedgehog signaling pathway_Homo sapiens_hsa043400.50705229
82Sulfur relay system_Homo sapiens_hsa041220.49555261
83Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48330923
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47670197
85Sulfur metabolism_Homo sapiens_hsa009200.47585571
86Cocaine addiction_Homo sapiens_hsa050300.46784887
87Amphetamine addiction_Homo sapiens_hsa050310.45157661
88Basal cell carcinoma_Homo sapiens_hsa052170.44606856
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44500137
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41544221
91Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.40844939
92Type I diabetes mellitus_Homo sapiens_hsa049400.38607822
93Dopaminergic synapse_Homo sapiens_hsa047280.35992441
94Fatty acid metabolism_Homo sapiens_hsa012120.35002834
95Circadian rhythm_Homo sapiens_hsa047100.34215947
96Tyrosine metabolism_Homo sapiens_hsa003500.31417909
97Vitamin digestion and absorption_Homo sapiens_hsa049770.30132320
98Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.29622888
99Nucleotide excision repair_Homo sapiens_hsa034200.27749573
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.24084271

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