HMGB1P16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)4.65558614
2maturation of SSU-rRNA (GO:0030490)4.56002535
3protein complex biogenesis (GO:0070271)4.48641435
4kynurenine metabolic process (GO:0070189)4.45181795
5heme transport (GO:0015886)4.21653720
6adaptation of signaling pathway (GO:0023058)4.11343237
7resolution of meiotic recombination intermediates (GO:0000712)4.10533337
8mitochondrial respiratory chain complex I assembly (GO:0032981)4.10368811
9NADH dehydrogenase complex assembly (GO:0010257)4.10368811
10mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.10368811
11cellular response to ATP (GO:0071318)4.10099888
12mitochondrial respiratory chain complex assembly (GO:0033108)4.04430291
13protein-cofactor linkage (GO:0018065)3.87813512
14indole-containing compound catabolic process (GO:0042436)3.87031097
15indolalkylamine catabolic process (GO:0046218)3.87031097
16tryptophan catabolic process (GO:0006569)3.87031097
17iron coordination entity transport (GO:1901678)3.86954818
18protein neddylation (GO:0045116)3.86541269
19ribosomal small subunit assembly (GO:0000028)3.85637271
20preassembly of GPI anchor in ER membrane (GO:0016254)3.79506003
21ATP synthesis coupled proton transport (GO:0015986)3.79102077
22energy coupled proton transport, down electrochemical gradient (GO:0015985)3.79102077
23tryptophan metabolic process (GO:0006568)3.77760173
24respiratory chain complex IV assembly (GO:0008535)3.70371575
25replication fork processing (GO:0031297)3.69674530
26chaperone-mediated protein transport (GO:0072321)3.65955853
27regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.63789487
28regulation of mitotic spindle checkpoint (GO:1903504)3.63789487
29tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.56206046
30RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.56206046
31indolalkylamine metabolic process (GO:0006586)3.55691481
32mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.52584859
33protein K63-linked deubiquitination (GO:0070536)3.50058671
34multicellular organism reproduction (GO:0032504)3.41212702
35behavioral response to nicotine (GO:0035095)3.39327498
36dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.35844398
37L-fucose catabolic process (GO:0042355)3.34324632
38fucose catabolic process (GO:0019317)3.34324632
39L-fucose metabolic process (GO:0042354)3.34324632
40rRNA catabolic process (GO:0016075)3.33458272
41maturation of 5.8S rRNA (GO:0000460)3.33239564
42cellular ketone body metabolic process (GO:0046950)3.32777116
43mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.31512257
44cytochrome complex assembly (GO:0017004)3.29535832
45DNA strand renaturation (GO:0000733)3.27000639
46rRNA modification (GO:0000154)3.22213453
47rRNA methylation (GO:0031167)3.20508196
48detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.15088028
49electron transport chain (GO:0022900)3.12114233
50regulation of cellular amino acid metabolic process (GO:0006521)3.11298689
51nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.09184170
52respiratory electron transport chain (GO:0022904)3.06323230
53negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.04921525
54detection of light stimulus involved in visual perception (GO:0050908)3.03013282
55detection of light stimulus involved in sensory perception (GO:0050962)3.03013282
56ncRNA catabolic process (GO:0034661)3.01657635
57exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.99342309
58GDP-mannose metabolic process (GO:0019673)2.98091683
59C-terminal protein amino acid modification (GO:0018410)2.94075650
60positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.93995143
61ketone body metabolic process (GO:1902224)2.93411124
62water-soluble vitamin biosynthetic process (GO:0042364)2.91905394
63DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.90797143
64mismatch repair (GO:0006298)2.87117118
65protein peptidyl-prolyl isomerization (GO:0000413)2.86833001
66C-terminal protein lipidation (GO:0006501)2.84621969
67DNA double-strand break processing (GO:0000729)2.82961857
68mannosylation (GO:0097502)2.82259175
69GTP biosynthetic process (GO:0006183)2.82081179
70maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.79334390
71signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.79127402
72intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.79127402
73signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.79034055
74signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.79034055
75signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.79034055
76lactate metabolic process (GO:0006089)2.78813783
77pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.78315891
78DNA catabolic process, exonucleolytic (GO:0000738)2.76284859
79positive regulation of prostaglandin secretion (GO:0032308)2.75391959
80response to pheromone (GO:0019236)2.73394318
81negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.72959383
82negative regulation of ligase activity (GO:0051352)2.72959383
83retinal cone cell development (GO:0046549)2.72865919
84regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.71895363
85aromatic amino acid family catabolic process (GO:0009074)2.70730382
86mitochondrial RNA metabolic process (GO:0000959)2.70057387
87amine catabolic process (GO:0009310)2.68674655
88cellular biogenic amine catabolic process (GO:0042402)2.68674655
89signal transduction involved in DNA integrity checkpoint (GO:0072401)2.66830751
90signal transduction involved in DNA damage checkpoint (GO:0072422)2.66830751
91signal peptide processing (GO:0006465)2.65405733
92GPI anchor metabolic process (GO:0006505)2.65113798
93signal transduction involved in cell cycle checkpoint (GO:0072395)2.64804928
94ncRNA 3-end processing (GO:0043628)2.60235278
95establishment of protein localization to mitochondrial membrane (GO:0090151)2.60004732
96recombinational repair (GO:0000725)2.59632861
97benzene-containing compound metabolic process (GO:0042537)2.58846672
98indole-containing compound metabolic process (GO:0042430)2.57225938
99GPI anchor biosynthetic process (GO:0006506)2.56998981
100seminiferous tubule development (GO:0072520)2.56912703

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.02348934
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.10962172
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.67257363
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.40699031
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.94092593
6IGF1R_20145208_ChIP-Seq_DFB_Human2.85744753
7ZNF274_21170338_ChIP-Seq_K562_Hela2.74887402
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.61141700
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.57287589
10VDR_22108803_ChIP-Seq_LS180_Human2.47981704
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.44623270
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.40550076
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.30296075
14ELK1_19687146_ChIP-ChIP_HELA_Human2.19586975
15EZH2_22144423_ChIP-Seq_EOC_Human2.12716185
16MYC_18940864_ChIP-ChIP_HL60_Human2.06401444
17VDR_23849224_ChIP-Seq_CD4+_Human1.97026680
18EWS_26573619_Chip-Seq_HEK293_Human1.90560284
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.83947584
20FOXP3_21729870_ChIP-Seq_TREG_Human1.78559095
21SRF_21415370_ChIP-Seq_HL-1_Mouse1.77573902
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.77111348
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.76941903
24CREB1_15753290_ChIP-ChIP_HEK293T_Human1.75244757
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.70376013
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.63885532
27IRF1_19129219_ChIP-ChIP_H3396_Human1.62794412
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.61830794
29E2F4_17652178_ChIP-ChIP_JURKAT_Human1.61151615
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.60369091
31FUS_26573619_Chip-Seq_HEK293_Human1.56992592
32GBX2_23144817_ChIP-Seq_PC3_Human1.54354651
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.52083042
34PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.50269582
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50214442
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49755792
37PCGF2_27294783_Chip-Seq_NPCs_Mouse1.47871204
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45764319
39P300_19829295_ChIP-Seq_ESCs_Human1.44424818
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43051124
41ER_23166858_ChIP-Seq_MCF-7_Human1.42437533
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.41398031
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.40625675
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38589419
45TAF2_19829295_ChIP-Seq_ESCs_Human1.30203776
46PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.27662553
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27523950
48FOXA1_27270436_Chip-Seq_PROSTATE_Human1.27371499
49FOXA1_25329375_ChIP-Seq_VCAP_Human1.27371499
50TP53_22573176_ChIP-Seq_HFKS_Human1.23510872
51PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22222528
52POU5F1_16153702_ChIP-ChIP_HESCs_Human1.18575982
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.15693341
54TAF15_26573619_Chip-Seq_HEK293_Human1.15354146
55RNF2_27304074_Chip-Seq_NSC_Mouse1.14623040
56ELK1_22589737_ChIP-Seq_MCF10A_Human1.14436623
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14082994
58TTF2_22483619_ChIP-Seq_HELA_Human1.13059098
59AR_20517297_ChIP-Seq_VCAP_Human1.11302486
60GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10683946
61MYC_18358816_ChIP-ChIP_MESCs_Mouse1.09867588
62SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07128693
63CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.06491958
64NCOR_22424771_ChIP-Seq_293T_Human1.06167835
65CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05468540
66RBPJ_21746931_ChIP-Seq_IB4_Human1.05376200
67DCP1A_22483619_ChIP-Seq_HELA_Human1.05269007
68AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04998667
69MYC_18555785_ChIP-Seq_MESCs_Mouse1.04026782
70THAP11_20581084_ChIP-Seq_MESCs_Mouse1.03607688
71LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03592333
72NFE2_27457419_Chip-Seq_LIVER_Mouse1.01604869
73POU3F2_20337985_ChIP-ChIP_501MEL_Human1.00654630
74AR_21572438_ChIP-Seq_LNCaP_Human1.00508217
75SOX2_19829295_ChIP-Seq_ESCs_Human0.99217432
76NANOG_19829295_ChIP-Seq_ESCs_Human0.99217432
77KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99085449
78CBP_20019798_ChIP-Seq_JUKART_Human0.98547474
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98547474
80CBX2_27304074_Chip-Seq_ESCs_Mouse0.98142385
81GATA3_21878914_ChIP-Seq_MCF-7_Human0.97978173
82GATA3_26560356_Chip-Seq_TH2_Human0.97805514
83GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.97528447
84GATA6_21074721_ChIP-Seq_CACO-2_Human0.97352402
85IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.96465513
86YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96299419
87MYC_19829295_ChIP-Seq_ESCs_Human0.95771137
88EZH2_27294783_Chip-Seq_NPCs_Mouse0.95614679
89HOXB7_26014856_ChIP-Seq_BT474_Human0.95433722
90TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.95335313
91FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94658667
92CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94400350
93PHF8_20622853_ChIP-Seq_HELA_Human0.93587041
94PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.92898078
95ETV1_20927104_ChIP-Seq_GIST48_Human0.92015805
96GABP_19822575_ChIP-Seq_HepG2_Human0.91901835
97PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.91379112
98ETV2_25802403_ChIP-Seq_MESCs_Mouse0.90851415
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89537609
100PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.88673908

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005646_abnormal_pituitary_gland3.65512975
2MP0006292_abnormal_olfactory_placode3.63456833
3MP0008875_abnormal_xenobiotic_pharmacok3.58773090
4MP0005645_abnormal_hypothalamus_physiol2.84967623
5MP0008995_early_reproductive_senescence2.66835011
6MP0008872_abnormal_physiological_respon2.52504690
7MP0002736_abnormal_nociception_after2.52077813
8MP0008877_abnormal_DNA_methylation2.45403963
9MP0004142_abnormal_muscle_tone2.34872870
10MP0003786_premature_aging2.24465749
11MP0005551_abnormal_eye_electrophysiolog2.20150758
12MP0001968_abnormal_touch/_nociception2.02489949
13MP0006072_abnormal_retinal_apoptosis1.99081491
14MP0003195_calcinosis1.96815580
15MP0003693_abnormal_embryo_hatching1.92731368
16MP0000372_irregular_coat_pigmentation1.88851430
17MP0001986_abnormal_taste_sensitivity1.85760874
18MP0003646_muscle_fatigue1.83183757
19MP0002234_abnormal_pharynx_morphology1.81598071
20MP0008789_abnormal_olfactory_epithelium1.78609093
21MP0003011_delayed_dark_adaptation1.77469243
22MP0002138_abnormal_hepatobiliary_system1.76742149
23MP0003045_fibrosis1.75994453
24MP0004147_increased_porphyrin_level1.73186891
25MP0005253_abnormal_eye_physiology1.66688095
26MP0009379_abnormal_foot_pigmentation1.65454691
27MP0003136_yellow_coat_color1.59118522
28MP0001905_abnormal_dopamine_level1.58214190
29MP0003567_abnormal_fetal_cardiomyocyte1.54557327
30MP0000631_abnormal_neuroendocrine_gland1.47837837
31MP0004145_abnormal_muscle_electrophysio1.46963606
32MP0005671_abnormal_response_to1.44852649
33MP0002277_abnormal_respiratory_mucosa1.42984611
34MP0002095_abnormal_skin_pigmentation1.38875055
35MP0005084_abnormal_gallbladder_morpholo1.35383326
36MP0005410_abnormal_fertilization1.35143329
37MP0008058_abnormal_DNA_repair1.31045449
38MP0004215_abnormal_myocardial_fiber1.30991424
39MP0004133_heterotaxia1.30270268
40MP0001873_stomach_inflammation1.29099151
41MP0002638_abnormal_pupillary_reflex1.28247436
42MP0002837_dystrophic_cardiac_calcinosis1.27360424
43MP0002938_white_spotting1.27130813
44MP0000427_abnormal_hair_cycle1.26811265
45MP0002163_abnormal_gland_morphology1.26722387
46MP0001485_abnormal_pinna_reflex1.24982845
47MP0003787_abnormal_imprinting1.24867683
48MP0003186_abnormal_redox_activity1.22445035
49MP0006276_abnormal_autonomic_nervous1.18070960
50MP0003890_abnormal_embryonic-extraembry1.15283977
51MP0003718_maternal_effect1.15210237
52MP0002102_abnormal_ear_morphology1.12817097
53MP0005636_abnormal_mineral_homeostasis1.12511098
54MP0001293_anophthalmia1.10938887
55MP0009333_abnormal_splenocyte_physiolog1.10564907
56MP0002733_abnormal_thermal_nociception1.08984973
57MP0001348_abnormal_lacrimal_gland1.06587397
58MP0001970_abnormal_pain_threshold1.00777546
59MP0002272_abnormal_nervous_system1.00276261
60MP0000613_abnormal_salivary_gland0.98644824
61MP0005389_reproductive_system_phenotype0.96160083
62MP0005075_abnormal_melanosome_morpholog0.94392659
63MP0001661_extended_life_span0.92348793
64MP0001984_abnormal_olfaction0.92199165
65MP0001835_abnormal_antigen_presentation0.91668363
66MP0002184_abnormal_innervation0.89837465
67MP0000647_abnormal_sebaceous_gland0.88532274
68MP0001501_abnormal_sleep_pattern0.88365835
69MP0005499_abnormal_olfactory_system0.88009458
70MP0005394_taste/olfaction_phenotype0.88009458
71MP0002735_abnormal_chemical_nociception0.87380283
72MP0001919_abnormal_reproductive_system0.86075867
73MP0001529_abnormal_vocalization0.85501016
74MP0005083_abnormal_biliary_tract0.85377463
75MP0002067_abnormal_sensory_capabilities0.85044516
76MP0002166_altered_tumor_susceptibility0.84019799
77MP0009745_abnormal_behavioral_response0.82076121
78MP0001502_abnormal_circadian_rhythm0.82024060
79MP0002006_tumorigenesis0.79213273
80MP0004043_abnormal_pH_regulation0.78995736
81MP0005174_abnormal_tail_pigmentation0.77878289
82MP0005391_vision/eye_phenotype0.77799354
83MP0004885_abnormal_endolymph0.77507267
84MP0005195_abnormal_posterior_eye0.76195488
85MP0001764_abnormal_homeostasis0.75223288
86MP0002160_abnormal_reproductive_system0.75113612
87MP0009046_muscle_twitch0.74825773
88MP0002572_abnormal_emotion/affect_behav0.74651406
89MP0000049_abnormal_middle_ear0.73749394
90MP0003938_abnormal_ear_development0.73151927
91MP0001800_abnormal_humoral_immune0.73054264
92MP0002229_neurodegeneration0.72818163
93MP0001119_abnormal_female_reproductive0.72638616
94MP0003880_abnormal_central_pattern0.72003283
95MP0009785_altered_susceptibility_to0.71520531
96MP0005332_abnormal_amino_acid0.70271008
97MP0001324_abnormal_eye_pigmentation0.69557180
98MP0003137_abnormal_impulse_conducting0.69397235
99MP0006036_abnormal_mitochondrial_physio0.68390745
100MP0002132_abnormal_respiratory_system0.67542148

Predicted human phenotypes

RankGene SetZ-score
1Reduced antithrombin III activity (HP:0001976)4.25873889
2Methylmalonic acidemia (HP:0002912)4.25525519
3Type I transferrin isoform profile (HP:0003642)3.93944309
4Acute necrotizing encephalopathy (HP:0006965)3.69036615
5Abnormal mitochondria in muscle tissue (HP:0008316)3.65096557
6Hypochromic microcytic anemia (HP:0004840)3.60728960
7Molar tooth sign on MRI (HP:0002419)3.53178917
8Abnormality of midbrain morphology (HP:0002418)3.53178917
9Methylmalonic aciduria (HP:0012120)3.46219449
10Renal cortical cysts (HP:0000803)3.36691967
11Hypoproteinemia (HP:0003075)3.30774879
12Acute encephalopathy (HP:0006846)3.26578234
13Pancreatic cysts (HP:0001737)3.26012647
14Mitochondrial inheritance (HP:0001427)3.21151488
15Pancreatic fibrosis (HP:0100732)3.18293111
16Increased CSF lactate (HP:0002490)3.14207165
17Abnormality of the pons (HP:0007361)3.12969459
18Hypoplasia of the pons (HP:0012110)3.05646890
19Nephronophthisis (HP:0000090)3.04093240
20Hepatocellular necrosis (HP:0001404)3.03305877
21Progressive macrocephaly (HP:0004481)3.02486467
22Congenital stationary night blindness (HP:0007642)2.99548671
23Abnormality of the renal cortex (HP:0011035)2.98823550
24Thyroid-stimulating hormone excess (HP:0002925)2.92055921
25True hermaphroditism (HP:0010459)2.81760734
26Hepatic necrosis (HP:0002605)2.80902880
27Congenital, generalized hypertrichosis (HP:0004540)2.77542715
28Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.74187704
29Abnormal protein N-linked glycosylation (HP:0012347)2.74187704
30Abnormal protein glycosylation (HP:0012346)2.74187704
31Abnormal glycosylation (HP:0012345)2.74187704
32Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.73760943
33Abnormality of alanine metabolism (HP:0010916)2.73760943
34Hyperalaninemia (HP:0003348)2.73760943
35Aplasia/Hypoplasia of the uvula (HP:0010293)2.73176406
36Increased intramyocellular lipid droplets (HP:0012240)2.70698662
37Aplasia/Hypoplasia of the spleen (HP:0010451)2.61595062
38Abnormality of DNA repair (HP:0003254)2.53738000
39Abnormality of the ileum (HP:0001549)2.53359358
40Decreased activity of mitochondrial respiratory chain (HP:0008972)2.51465455
41Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.51465455
42Asplenia (HP:0001746)2.49106344
43Abnormality of the renal medulla (HP:0100957)2.47645651
44Absent thumb (HP:0009777)2.43409335
45Large for gestational age (HP:0001520)2.41895479
46Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.40576250
47Meckel diverticulum (HP:0002245)2.38879642
48Abnormality of the vitamin B12 metabolism (HP:0004341)2.34623302
49IgG deficiency (HP:0004315)2.33616714
50Increased hepatocellular lipid droplets (HP:0006565)2.28693951
51Cerebral edema (HP:0002181)2.28033291
52Stomatitis (HP:0010280)2.25232079
53Lactic acidosis (HP:0003128)2.19096109
54Optic disc pallor (HP:0000543)2.15511643
55Abnormality of vitamin B metabolism (HP:0004340)2.13174875
56Cystic liver disease (HP:0006706)2.10893783
57Increased serum lactate (HP:0002151)2.07256684
58Abolished electroretinogram (ERG) (HP:0000550)2.06853203
59Adrenal hypoplasia (HP:0000835)2.06239323
60Increased muscle lipid content (HP:0009058)2.06152204
61Hyperglycinemia (HP:0002154)2.04662094
62Abnormality of the preputium (HP:0100587)2.04414492
63Abnormality of macular pigmentation (HP:0008002)2.03179769
64Medial flaring of the eyebrow (HP:0010747)2.03024653
65Hypoplasia of the capital femoral epiphysis (HP:0003090)2.02253945
66Sclerocornea (HP:0000647)1.99793315
67Respiratory failure (HP:0002878)1.99697879
68Lipid accumulation in hepatocytes (HP:0006561)1.98970442
69Anencephaly (HP:0002323)1.94568638
70Renal Fanconi syndrome (HP:0001994)1.94336667
71Lethargy (HP:0001254)1.94335553
72Aplasia/Hypoplasia of the tongue (HP:0010295)1.91656273
73Decreased electroretinogram (ERG) amplitude (HP:0000654)1.91329858
74Clubbing of toes (HP:0100760)1.89663675
75CNS demyelination (HP:0007305)1.89306378
76Type 2 muscle fiber atrophy (HP:0003554)1.88749942
773-Methylglutaconic aciduria (HP:0003535)1.88478624
78Elevated erythrocyte sedimentation rate (HP:0003565)1.88368382
79Abnormality of chromosome stability (HP:0003220)1.86110464
80Poor head control (HP:0002421)1.85603701
81Abnormality of dicarboxylic acid metabolism (HP:0010995)1.83330532
82Dicarboxylic aciduria (HP:0003215)1.83330532
83Tubulointerstitial nephritis (HP:0001970)1.81433484
84Reticulocytopenia (HP:0001896)1.81199317
85Leukodystrophy (HP:0002415)1.80600879
86Ketosis (HP:0001946)1.78355576
87Nephrogenic diabetes insipidus (HP:0009806)1.77565138
88Intestinal atresia (HP:0011100)1.76343885
89Concave nail (HP:0001598)1.75838182
90Chromsome breakage (HP:0040012)1.75766089
91Triphalangeal thumb (HP:0001199)1.73731459
92Postaxial foot polydactyly (HP:0001830)1.72375052
93Oligohydramnios (HP:0001562)1.71951194
94Neutropenia (HP:0001875)1.71401468
95Lissencephaly (HP:0001339)1.70936962
96Supernumerary spleens (HP:0009799)1.70405130
97Exercise intolerance (HP:0003546)1.67117134
98Colon cancer (HP:0003003)1.66943071
99Abnormal respiratory motile cilium physiology (HP:0012261)1.66831154
100Abnormal drinking behavior (HP:0030082)1.65924184

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK25.62227845
2STK163.00824870
3TXK2.68561851
4TLK12.66301872
5SCYL22.66006480
6MAP4K22.40870514
7STK38L2.40868474
8FRK2.24454100
9VRK22.22976513
10NUAK12.15429775
11EIF2AK32.08594787
12NME12.06782364
13STK241.93220608
14MST41.92838563
15ADRBK21.81987598
16TSSK61.77482379
17BMPR1B1.76418224
18GRK11.66577190
19CDK191.63687644
20PBK1.63472746
21ZAK1.60515733
22BCKDK1.48566962
23NEK11.44995490
24BUB11.38104323
25VRK11.34722636
26MAPK131.32909597
27TAOK31.31702210
28PLK21.29074988
29PLK31.21211211
30OXSR11.18874793
31MAP4K11.14818988
32MKNK11.14567937
33MARK11.08861315
34TIE11.08475936
35CAMKK21.08470002
36TNK21.06837680
37PHKG11.04820362
38PHKG21.04820362
39WNK41.04576277
40WNK31.03861242
41GRK70.90787866
42TAF10.90033003
43CSNK1G20.89471781
44MAPKAPK30.86757334
45PLK40.82986663
46INSRR0.82815903
47NEK90.81419162
48PINK10.81395680
49MAP2K60.81051976
50MINK10.79290513
51MKNK20.79031690
52KDR0.79006305
53CSNK1G30.75250693
54ADRBK10.74721080
55PRKCI0.74174342
56PRKCQ0.73614483
57EIF2AK20.73550413
58DYRK20.71178701
59MAPKAPK50.70389236
60STK390.68571233
61NEK60.66985394
62SYK0.66287225
63PRKCE0.64645025
64KIT0.60026924
65PRKCG0.59191074
66ERBB30.51517539
67CLK10.51061183
68AURKA0.50795645
69NTRK20.50533052
70TNIK0.49767332
71PLK10.49633222
72PRKACA0.48961088
73CDC70.48450495
74CSNK1G10.47869825
75CSNK1A1L0.46168666
76CAMK2A0.45933325
77TEC0.45665960
78GRK50.45177095
79PAK30.43021016
80WNK10.41207967
81CSNK2A20.40937959
82IKBKB0.40911560
83BTK0.40598756
84CSNK2A10.40352189
85IKBKE0.40041865
86EPHB20.39917469
87SRPK10.39643335
88PRKCA0.37267570
89PIK3CA0.36940447
90RPS6KA50.35817788
91ITK0.35038944
92BRSK10.34980943
93CHEK20.33676824
94MAP2K70.33254012
95CAMK2D0.32846160
96PRKACG0.32658139
97BCR0.32090412
98PIK3CG0.32022831
99ATR0.30745282
100OBSCN0.30202704

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.71188411
2Oxidative phosphorylation_Homo sapiens_hsa001902.89192383
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.80116832
4Ribosome_Homo sapiens_hsa030102.44451912
5Homologous recombination_Homo sapiens_hsa034402.36499601
6Parkinsons disease_Homo sapiens_hsa050122.24188048
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.22593786
8Mismatch repair_Homo sapiens_hsa034302.15499630
9Tryptophan metabolism_Homo sapiens_hsa003802.15285377
10One carbon pool by folate_Homo sapiens_hsa006702.12902031
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.10058178
12Fanconi anemia pathway_Homo sapiens_hsa034602.05623174
13Protein export_Homo sapiens_hsa030602.03996880
14Propanoate metabolism_Homo sapiens_hsa006402.01578687
15Butanoate metabolism_Homo sapiens_hsa006501.88547183
16RNA polymerase_Homo sapiens_hsa030201.87261306
17Nucleotide excision repair_Homo sapiens_hsa034201.83036272
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.81073263
19Fatty acid elongation_Homo sapiens_hsa000621.76060257
20DNA replication_Homo sapiens_hsa030301.70358315
21Phototransduction_Homo sapiens_hsa047441.68573787
22Huntingtons disease_Homo sapiens_hsa050161.60963667
23Base excision repair_Homo sapiens_hsa034101.59515564
24Peroxisome_Homo sapiens_hsa041461.53137462
25Linoleic acid metabolism_Homo sapiens_hsa005911.52586063
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.46855022
27Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.45215703
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.44510304
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.42349337
30beta-Alanine metabolism_Homo sapiens_hsa004101.42298460
31Alzheimers disease_Homo sapiens_hsa050101.38373067
32Nitrogen metabolism_Homo sapiens_hsa009101.38265262
33Fatty acid degradation_Homo sapiens_hsa000711.35118975
34Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.31415214
35Asthma_Homo sapiens_hsa053101.30131477
36Cardiac muscle contraction_Homo sapiens_hsa042601.23075084
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.22703712
38Folate biosynthesis_Homo sapiens_hsa007901.22537236
39RNA degradation_Homo sapiens_hsa030181.18130453
40Basal transcription factors_Homo sapiens_hsa030221.13394197
41Primary immunodeficiency_Homo sapiens_hsa053401.09109069
42Pyrimidine metabolism_Homo sapiens_hsa002401.09077122
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.08240785
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.06818106
45Purine metabolism_Homo sapiens_hsa002301.02348217
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.99260696
47Pyruvate metabolism_Homo sapiens_hsa006200.95966508
48Ether lipid metabolism_Homo sapiens_hsa005650.94523435
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.93832093
50RNA transport_Homo sapiens_hsa030130.93565758
51Spliceosome_Homo sapiens_hsa030400.91552112
52Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.91537905
53Chemical carcinogenesis_Homo sapiens_hsa052040.91382079
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91044787
55Allograft rejection_Homo sapiens_hsa053300.90339924
56Caffeine metabolism_Homo sapiens_hsa002320.88278147
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86379304
58Fatty acid metabolism_Homo sapiens_hsa012120.86132591
59Arachidonic acid metabolism_Homo sapiens_hsa005900.86098229
60Autoimmune thyroid disease_Homo sapiens_hsa053200.85264283
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.84998246
62Retinol metabolism_Homo sapiens_hsa008300.84235792
63Vitamin digestion and absorption_Homo sapiens_hsa049770.82101421
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.81954963
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.80478744
66Metabolic pathways_Homo sapiens_hsa011000.76868712
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76806994
68Glutathione metabolism_Homo sapiens_hsa004800.75947668
69N-Glycan biosynthesis_Homo sapiens_hsa005100.72891472
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71941028
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.71738319
72Olfactory transduction_Homo sapiens_hsa047400.68551011
73Tyrosine metabolism_Homo sapiens_hsa003500.67459705
74Fat digestion and absorption_Homo sapiens_hsa049750.65330700
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64856880
76Non-homologous end-joining_Homo sapiens_hsa034500.64537823
77Histidine metabolism_Homo sapiens_hsa003400.56112071
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55994897
79Sulfur metabolism_Homo sapiens_hsa009200.55677962
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55661907
81Antigen processing and presentation_Homo sapiens_hsa046120.52710490
82Salivary secretion_Homo sapiens_hsa049700.51240341
83Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.46431903
84Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46071022
85ABC transporters_Homo sapiens_hsa020100.44696091
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44412386
87Thyroid hormone synthesis_Homo sapiens_hsa049180.40243569
88Insulin secretion_Homo sapiens_hsa049110.38087561
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37851661
90Glycerolipid metabolism_Homo sapiens_hsa005610.37767445
91Arginine and proline metabolism_Homo sapiens_hsa003300.36853577
92Hematopoietic cell lineage_Homo sapiens_hsa046400.35913002
93Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.35574861
94Starch and sucrose metabolism_Homo sapiens_hsa005000.35442306
95Ovarian steroidogenesis_Homo sapiens_hsa049130.34938679
96Sulfur relay system_Homo sapiens_hsa041220.33578960
97Morphine addiction_Homo sapiens_hsa050320.31489348
98Collecting duct acid secretion_Homo sapiens_hsa049660.31047561
99Cyanoamino acid metabolism_Homo sapiens_hsa004600.30801298
100SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30027123

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »