ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.76519301
2	neural tube formation (GO:0001841)	4.32120299
3	Notch signaling involved in heart development (GO:0061314)	4.24994717
4	DNA deamination (GO:0045006)	4.16717184
5	tachykinin receptor signaling pathway (GO:0007217)	4.12551232
6	regulation of timing of cell differentiation (GO:0048505)	4.12228869
7	retinal cone cell development (GO:0046549)	4.07765414
8	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	3.95853258
9	regulation of development, heterochronic (GO:0040034)	3.91419795
10	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.69738262
11	behavioral response to nicotine (GO:0035095)	3.69329430
12	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.65035393
13	auditory receptor cell differentiation (GO:0042491)	3.63213615
14	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.50335431
15	protein complex biogenesis (GO:0070271)	3.44867120
16	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.43125951
17	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.41663949
18	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.41663949
19	NADH dehydrogenase complex assembly (GO:0010257)	3.41663949
20	kinetochore assembly (GO:0051382)	3.30400304
21	kinetochore organization (GO:0051383)	3.23473084
22	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.21900132
23	water-soluble vitamin biosynthetic process (GO:0042364)	3.21320141
24	adaptation of signaling pathway (GO:0023058)	3.20319557
25	positive regulation of action potential (GO:0045760)	3.18564373
26	protein neddylation (GO:0045116)	3.17436821
27	mitochondrial respiratory chain complex assembly (GO:0033108)	3.14437465
28	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	3.13316922
29	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.06362542
30	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.05231358
31	ATP synthesis coupled proton transport (GO:0015986)	3.05231358
32	nonmotile primary cilium assembly (GO:0035058)	3.04528128
33	rRNA modification (GO:0000154)	3.04444696
34	dopamine transport (GO:0015872)	3.03059195
35	hepatocyte apoptotic process (GO:0097284)	3.02151948
36	spinal cord association neuron differentiation (GO:0021527)	2.99756630
37	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.99456401
38	head development (GO:0060322)	2.99093750
39	replication fork processing (GO:0031297)	2.96660865
40	regulation of energy homeostasis (GO:2000505)	2.94241627
41	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.93242626
42	regulation of cilium movement (GO:0003352)	2.92853532
43	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.90068911
44	positive regulation of prostaglandin secretion (GO:0032308)	2.86891532
45	negative regulation of telomere maintenance (GO:0032205)	2.86434358
46	chromatin remodeling at centromere (GO:0031055)	2.85783883
47	pyrimidine nucleobase catabolic process (GO:0006208)	2.84705661
48	protein polyglutamylation (GO:0018095)	2.83796000
49	regulation of action potential (GO:0098900)	2.82659901
50	chaperone-mediated protein transport (GO:0072321)	2.82217977
51	response to pheromone (GO:0019236)	2.77383101
52	platelet dense granule organization (GO:0060155)	2.76874904
53	respiratory chain complex IV assembly (GO:0008535)	2.76733357
54	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	2.72399483
55	cilium morphogenesis (GO:0060271)	2.70307788
56	L-fucose catabolic process (GO:0042355)	2.69613851
57	fucose catabolic process (GO:0019317)	2.69613851
58	L-fucose metabolic process (GO:0042354)	2.69613851
59	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.69036975
60	olfactory bulb development (GO:0021772)	2.68958956
61	epithelial cilium movement (GO:0003351)	2.68868178
62	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.67901525
63	cell proliferation in forebrain (GO:0021846)	2.66690249
64	DNA demethylation (GO:0080111)	2.66456670
65	cell wall macromolecule catabolic process (GO:0016998)	2.64772703
66	rhodopsin mediated signaling pathway (GO:0016056)	2.64618624
67	recombinational repair (GO:0000725)	2.64260901
68	CENP-A containing nucleosome assembly (GO:0034080)	2.63540211
69	behavioral response to ethanol (GO:0048149)	2.62533166
70	somite development (GO:0061053)	2.61397740
71	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.59742762
72	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.59742762
73	isotype switching (GO:0045190)	2.59742762
74	nucleobase biosynthetic process (GO:0046112)	2.59284317
75	protein-cofactor linkage (GO:0018065)	2.59253997
76	positive regulation of cell fate commitment (GO:0010455)	2.57069375
77	cilium movement (GO:0003341)	2.57022742
78	peroxisome fission (GO:0016559)	2.56563120
79	piRNA metabolic process (GO:0034587)	2.55303925
80	double-strand break repair via homologous recombination (GO:0000724)	2.55212124
81	rRNA methylation (GO:0031167)	2.55000976
82	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.54984061
83	protein K6-linked ubiquitination (GO:0085020)	2.54743652
84	negative regulation of DNA recombination (GO:0045910)	2.54545135
85	axoneme assembly (GO:0035082)	2.52347311
86	substrate-independent telencephalic tangential migration (GO:0021826)	2.52212475
87	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.52212475
88	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.51788433
89	telomere maintenance via telomerase (GO:0007004)	2.50657477
90	ventricular trabecula myocardium morphogenesis (GO:0003222)	2.50421683
91	forebrain neuron differentiation (GO:0021879)	2.49343429
92	cardiac left ventricle morphogenesis (GO:0003214)	2.47549520
93	aggressive behavior (GO:0002118)	2.46260187
94	tongue development (GO:0043586)	2.45795114
95	photoreceptor cell development (GO:0042461)	2.44813411
96	regulation of immunoglobulin secretion (GO:0051023)	2.44198624
97	protein localization to cilium (GO:0061512)	2.43036294
98	synaptic transmission, cholinergic (GO:0007271)	2.39786973
99	intracellular protein transmembrane import (GO:0044743)	2.39161448
100	cilium or flagellum-dependent cell motility (GO:0001539)	2.38189450

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.23711919
2	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.00576619
3	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.00380334
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.00278887
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.86253496
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.78432581
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.77950994
8	VDR_22108803_ChIP-Seq_LS180_Human	2.75586440
9	GBX2_23144817_ChIP-Seq_PC3_Human	2.70838238
10	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.64749985
11	EWS_26573619_Chip-Seq_HEK293_Human	2.59681646
12	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.46504418
13	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.45333618
14	FUS_26573619_Chip-Seq_HEK293_Human	2.44887804
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.35220806
16	TAF15_26573619_Chip-Seq_HEK293_Human	2.33964823
17	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.28625077
18	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.28293354
19	ELK1_19687146_ChIP-ChIP_HELA_Human	2.25409007
20	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.09650459
21	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.02676162
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.01904994
23	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.01818291
24	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.01709853
25	P300_19829295_ChIP-Seq_ESCs_Human	1.96989607
26	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.93740834
27	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.93310731
28	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.91105439
29	EZH2_22144423_ChIP-Seq_EOC_Human	1.71999860
30	VDR_23849224_ChIP-Seq_CD4+_Human	1.70398035
31	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.67019187
32	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.61228944
33	ER_23166858_ChIP-Seq_MCF-7_Human	1.59902717
34	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.59159012
35	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.55779988
36	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.55779988
37	SMAD4_21799915_ChIP-Seq_A2780_Human	1.53136027
38	CBP_20019798_ChIP-Seq_JUKART_Human	1.49441062
39	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.49441062
40	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.47499820
41	TP53_22573176_ChIP-Seq_HFKS_Human	1.46712021
42	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.43295688
43	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.43078779
44	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.42479259
45	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.41951220
46	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.41422490
47	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.40434122
48	STAT3_23295773_ChIP-Seq_U87_Human	1.37594250
49	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.37344916
50	IRF1_19129219_ChIP-ChIP_H3396_Human	1.34597757
51	MYC_18940864_ChIP-ChIP_HL60_Human	1.32276550
52	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.32121079
53	NANOG_19829295_ChIP-Seq_ESCs_Human	1.31584510
54	SOX2_19829295_ChIP-Seq_ESCs_Human	1.31584510
55	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.30432475
56	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.30071393
57	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.28420686
58	RNF2_27304074_Chip-Seq_NSC_Mouse	1.28164182
59	TCF4_22108803_ChIP-Seq_LS180_Human	1.27327768
60	P53_22387025_ChIP-Seq_ESCs_Mouse	1.26723976
61	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.25385382
62	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.25290981
63	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.25267039
64	AR_25329375_ChIP-Seq_VCAP_Human	1.25185676
65	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.23681136
66	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.23453668
67	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.22288702
68	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.22188661
69	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.21730185
70	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.20951705
71	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.20092479
72	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.19713158
73	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.17803525
74	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.17016232
75	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.16576716
76	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.15996425
77	TCF4_23295773_ChIP-Seq_U87_Human	1.15434138
78	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.14039984
79	RXR_22108803_ChIP-Seq_LS180_Human	1.12082363
80	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.10595294
81	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.10519983
82	BCAT_22108803_ChIP-Seq_LS180_Human	1.09718064
83	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.08008034
84	RUNX2_22187159_ChIP-Seq_PCA_Human	1.05389228
85	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.05228807
86	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.03780242
87	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.03351470
88	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.02470151
89	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.02448479
90	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.00978589
91	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.00474086
92	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.00474086
93	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.00133900
94	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.99557563
95	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.99475505
96	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.99254996
97	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.99083360
98	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.98689326
99	P300_18555785_Chip-Seq_ESCs_Mouse	0.98308888
100	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.97635169

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002736_abnormal_nociception_after	3.46221077
2	MP0000569_abnormal_digit_pigmentation	3.41834692
3	MP0002102_abnormal_ear_morphology	3.32602266
4	MP0001529_abnormal_vocalization	3.03038407
5	MP0000372_irregular_coat_pigmentation	2.94817248
6	MP0008877_abnormal_DNA_methylation	2.83777593
7	MP0006292_abnormal_olfactory_placode	2.76242230
8	MP0001968_abnormal_touch/_nociception	2.64931921
9	MP0003252_abnormal_bile_duct	2.56089936
10	MP0003880_abnormal_central_pattern	2.52602333
11	MP0001984_abnormal_olfaction	2.29790008
12	MP0005645_abnormal_hypothalamus_physiol	2.27166552
13	MP0002938_white_spotting	2.26698228
14	MP0005084_abnormal_gallbladder_morpholo	2.20397494
15	MP0005367_renal/urinary_system_phenotyp	2.16640186
16	MP0000516_abnormal_urinary_system	2.16640186
17	MP0002837_dystrophic_cardiac_calcinosis	2.13269719
18	MP0002928_abnormal_bile_duct	2.07864986
19	MP0006072_abnormal_retinal_apoptosis	1.98885667
20	MP0004142_abnormal_muscle_tone	1.98871092
21	MP0008789_abnormal_olfactory_epithelium	1.86452360
22	MP0005646_abnormal_pituitary_gland	1.79951784
23	MP0008058_abnormal_DNA_repair	1.74033012
24	MP0005551_abnormal_eye_electrophysiolog	1.72086010
25	MP0002095_abnormal_skin_pigmentation	1.71499414
26	MP0005253_abnormal_eye_physiology	1.60407926
27	MP0000427_abnormal_hair_cycle	1.58534645
28	MP0000778_abnormal_nervous_system	1.58352770
29	MP0002735_abnormal_chemical_nociception	1.56547559
30	MP0003787_abnormal_imprinting	1.55220024
31	MP0001293_anophthalmia	1.53861905
32	MP0003195_calcinosis	1.53484902
33	MP0005174_abnormal_tail_pigmentation	1.50734295
34	MP0005394_taste/olfaction_phenotype	1.45939501
35	MP0005499_abnormal_olfactory_system	1.45939501
36	MP0003646_muscle_fatigue	1.45850368
37	MP0001485_abnormal_pinna_reflex	1.41024066
38	MP0000647_abnormal_sebaceous_gland	1.40917153
39	MP0009697_abnormal_copulation	1.39705955
40	MP0004147_increased_porphyrin_level	1.37244595
41	MP0008872_abnormal_physiological_respon	1.33251816
42	MP0001486_abnormal_startle_reflex	1.32234950
43	MP0000685_abnormal_immune_system	1.32049567
44	MP0002138_abnormal_hepatobiliary_system	1.31075292
45	MP0009780_abnormal_chondrocyte_physiolo	1.25294176
46	MP0005075_abnormal_melanosome_morpholog	1.20947905
47	MP0005187_abnormal_penis_morphology	1.20660326
48	MP0004133_heterotaxia	1.20438773
49	MP0009745_abnormal_behavioral_response	1.18202848
50	MP0004145_abnormal_muscle_electrophysio	1.12693321
51	MP0008875_abnormal_xenobiotic_pharmacok	1.10400808
52	MP0000631_abnormal_neuroendocrine_gland	1.10249205
53	MP0004742_abnormal_vestibular_system	1.09158190
54	MP0002557_abnormal_social/conspecific_i	1.08715808
55	MP0002234_abnormal_pharynx_morphology	1.08200795
56	MP0002067_abnormal_sensory_capabilities	1.07645111
57	MP0005195_abnormal_posterior_eye	1.06735671
58	MP0003567_abnormal_fetal_cardiomyocyte	1.06658023
59	MP0004885_abnormal_endolymph	1.06431571
60	MP0010094_abnormal_chromosome_stability	1.04973050
61	MP0002272_abnormal_nervous_system	1.04732583
62	MP0002233_abnormal_nose_morphology	1.04172740
63	MP0004215_abnormal_myocardial_fiber	1.02723298
64	MP0001440_abnormal_grooming_behavior	1.01563630
65	MP0002751_abnormal_autonomic_nervous	1.00818777
66	MP0006054_spinal_hemorrhage	1.00481793
67	MP0003937_abnormal_limbs/digits/tail_de	0.96174124
68	MP0005391_vision/eye_phenotype	0.95334823
69	MP0003755_abnormal_palate_morphology	0.93124542
70	MP0008057_abnormal_DNA_replication	0.92973795
71	MP0009379_abnormal_foot_pigmentation	0.92088716
72	MP0002160_abnormal_reproductive_system	0.90114347
73	MP0002277_abnormal_respiratory_mucosa	0.89441731
74	MP0008775_abnormal_heart_ventricle	0.89055028
75	MP0001286_abnormal_eye_development	0.88981187
76	MP0001970_abnormal_pain_threshold	0.86477637
77	MP0000049_abnormal_middle_ear	0.85296638
78	MP0002734_abnormal_mechanical_nocicepti	0.84361927
79	MP0002572_abnormal_emotion/affect_behav	0.84270019
80	MP0002752_abnormal_somatic_nervous	0.84150836
81	MP0008007_abnormal_cellular_replicative	0.82653774
82	MP0004924_abnormal_behavior	0.82578419
83	MP0005386_behavior/neurological_phenoty	0.82578419
84	MP0003718_maternal_effect	0.80759973
85	MP0009046_muscle_twitch	0.78286069
86	MP0005085_abnormal_gallbladder_physiolo	0.77504625
87	MP0003786_premature_aging	0.76816973
88	MP0001929_abnormal_gametogenesis	0.75248621
89	MP0002733_abnormal_thermal_nociception	0.74236372
90	MP0002396_abnormal_hematopoietic_system	0.69847226
91	MP0009764_decreased_sensitivity_to	0.68388332
92	MP0000538_abnormal_urinary_bladder	0.68114868
93	MP0003698_abnormal_male_reproductive	0.66856356
94	MP0005389_reproductive_system_phenotype	0.66628233
95	MP0003890_abnormal_embryonic-extraembry	0.66021245
96	MP0005410_abnormal_fertilization	0.65558984
97	MP0001188_hyperpigmentation	0.64904558
98	MP0001835_abnormal_antigen_presentation	0.64428870
99	MP0000026_abnormal_inner_ear	0.62050101
100	MP0002876_abnormal_thyroid_physiology	0.61989793

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Type II lissencephaly (HP:0007260)	4.39606577
2	Abnormality of midbrain morphology (HP:0002418)	3.93108869
3	Molar tooth sign on MRI (HP:0002419)	3.93108869
4	Pancreatic cysts (HP:0001737)	3.73973749
5	True hermaphroditism (HP:0010459)	3.68217152
6	Pancreatic fibrosis (HP:0100732)	3.67379100
7	Acute necrotizing encephalopathy (HP:0006965)	3.64484326
8	Medial flaring of the eyebrow (HP:0010747)	3.47780360
9	Progressive macrocephaly (HP:0004481)	3.36036743
10	Fair hair (HP:0002286)	3.18978459
11	Hypoplasia of the pons (HP:0012110)	3.14278515
12	Abnormal mitochondria in muscle tissue (HP:0008316)	3.03992568
13	Abnormality of the pons (HP:0007361)	3.00976971
14	Acute encephalopathy (HP:0006846)	2.95640535
15	Gait imbalance (HP:0002141)	2.90144154
16	Lissencephaly (HP:0001339)	2.88182621
17	Abnormality of the renal cortex (HP:0011035)	2.86810062
18	Mitochondrial inheritance (HP:0001427)	2.81502144
19	Cerebellar dysplasia (HP:0007033)	2.74921135
20	Septo-optic dysplasia (HP:0100842)	2.73276436
21	Retinal dysplasia (HP:0007973)	2.73066289
22	Congenital primary aphakia (HP:0007707)	2.71880439
23	Increased CSF lactate (HP:0002490)	2.71766760
24	Abnormality of the renal medulla (HP:0100957)	2.64324506
25	Intestinal atresia (HP:0011100)	2.62824908
26	Hypoplastic iliac wings (HP:0002866)	2.53190032
27	Increased hepatocellular lipid droplets (HP:0006565)	2.51086388
28	Abnormality of the labia minora (HP:0012880)	2.48225512
29	Nephronophthisis (HP:0000090)	2.45916434
30	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.40347979
31	Postaxial foot polydactyly (HP:0001830)	2.40208806
32	Chronic hepatic failure (HP:0100626)	2.37361816
33	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.36073752
34	Nephrogenic diabetes insipidus (HP:0009806)	2.33262153
35	Lipid accumulation in hepatocytes (HP:0006561)	2.32466272
36	Chorioretinal atrophy (HP:0000533)	2.31718541
37	Optic nerve hypoplasia (HP:0000609)	2.31104738
38	Attenuation of retinal blood vessels (HP:0007843)	2.24449245
39	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.22874070
40	Abnormal rod and cone electroretinograms (HP:0008323)	2.22104769
41	Thyroiditis (HP:0100646)	2.21824736
42	Congenital, generalized hypertrichosis (HP:0004540)	2.21280229
43	Renal cortical cysts (HP:0000803)	2.19974986
44	Optic disc pallor (HP:0000543)	2.18228851
45	Postaxial hand polydactyly (HP:0001162)	2.16509571
46	Congenital hepatic fibrosis (HP:0002612)	2.14363927
47	Generalized hypopigmentation of hair (HP:0011358)	2.09806157
48	Congenital stationary night blindness (HP:0007642)	2.08190047
49	Tubular atrophy (HP:0000092)	2.07667145
50	Genital tract atresia (HP:0001827)	2.07307831
51	Abnormality of the metopic suture (HP:0005556)	2.07281059
52	Abnormal hair whorl (HP:0010721)	2.06885076
53	Vaginal atresia (HP:0000148)	2.06363645
54	Hyperglycinemia (HP:0002154)	2.03646353
55	Dandy-Walker malformation (HP:0001305)	2.03582433
56	Keratoconus (HP:0000563)	2.02991313
57	Increased corneal curvature (HP:0100692)	2.02991313
58	Disproportionate short-trunk short stature (HP:0003521)	2.02914214
59	Cystic liver disease (HP:0006706)	2.02428748
60	Progressive cerebellar ataxia (HP:0002073)	1.98498704
61	Constricted visual fields (HP:0001133)	1.97027376
62	Hypoproteinemia (HP:0003075)	1.96287086
63	Methylmalonic acidemia (HP:0002912)	1.95939359
64	Rhinitis (HP:0012384)	1.94202240
65	Pendular nystagmus (HP:0012043)	1.93666888
66	Abolished electroretinogram (ERG) (HP:0000550)	1.90896511
67	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.89255997
68	Prominent metopic ridge (HP:0005487)	1.88703209
69	Poor coordination (HP:0002370)	1.87690205
70	Rib fusion (HP:0000902)	1.86844662
71	Bony spicule pigmentary retinopathy (HP:0007737)	1.86018182
72	3-Methylglutaconic aciduria (HP:0003535)	1.85018489
73	Progressive inability to walk (HP:0002505)	1.84799995
74	Sclerocornea (HP:0000647)	1.84057690
75	Colon cancer (HP:0003003)	1.83656387
76	Aganglionic megacolon (HP:0002251)	1.82951014
77	Anencephaly (HP:0002323)	1.82659455
78	Cerebral edema (HP:0002181)	1.81800126
79	Bilateral microphthalmos (HP:0007633)	1.78985820
80	Renal Fanconi syndrome (HP:0001994)	1.78606400
81	Oligodactyly (hands) (HP:0001180)	1.74762506
82	Adactyly (HP:0009776)	1.74482383
83	Prominent nasal bridge (HP:0000426)	1.74090166
84	Abnormality of B cell number (HP:0010975)	1.73544971
85	Male pseudohermaphroditism (HP:0000037)	1.73533783
86	Ectopic kidney (HP:0000086)	1.73525439
87	Leukodystrophy (HP:0002415)	1.73357142
88	Narrow forehead (HP:0000341)	1.73127429
89	Oligodactyly (HP:0012165)	1.72280145
90	Hepatocellular necrosis (HP:0001404)	1.72214729
91	Small hand (HP:0200055)	1.71288565
92	Congenital sensorineural hearing impairment (HP:0008527)	1.70892045
93	B lymphocytopenia (HP:0010976)	1.69398582
94	Abnormality of the ileum (HP:0001549)	1.68432540
95	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.67680115
96	Gaze-evoked nystagmus (HP:0000640)	1.67196153
97	Progressive microcephaly (HP:0000253)	1.66278804
98	Pachygyria (HP:0001302)	1.64748832
99	Abnormal respiratory motile cilium morphology (HP:0005938)	1.64725381
100	Abnormal respiratory epithelium morphology (HP:0012253)	1.64725381

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.64681259
2	MAP4K2	2.88206941
3	NUAK1	2.55874202
4	TNIK	2.47121181
5	TXK	2.31510359
6	MAPK13	2.28372876
7	TSSK6	2.22829629
8	WNK3	1.98733517
9	CAMKK2	1.93322335
10	MAP3K12	1.91615413
11	ZAK	1.90736285
12	EIF2AK3	1.81568823
13	VRK1	1.63233061
14	PNCK	1.61388740
15	PAK3	1.60952947
16	BMPR1B	1.51951978
17	TAOK3	1.49842303
18	IRAK1	1.49269697
19	PLK2	1.48195273
20	ADRBK2	1.46164921
21	PIK3CA	1.45422615
22	TLK1	1.42866565
23	PINK1	1.41968421
24	BRSK2	1.40064650
25	TAF1	1.39688967
26	PLK3	1.38166520
27	EIF2AK1	1.36698580
28	MST4	1.36360422
29	EPHA4	1.33250162
30	DYRK2	1.25973420
31	GRK1	1.25361126
32	AKT3	1.21599227
33	ACVR1B	1.21111222
34	TRIM28	1.20919069
35	PLK4	1.18782306
36	WEE1	1.18665575
37	VRK2	1.16562404
38	DAPK2	1.16132486
39	ERBB3	1.15763130
40	MKNK2	1.14566891
41	BUB1	1.10696309
42	OXSR1	1.07193723
43	MARK1	1.03391331
44	CSNK1G1	1.03362242
45	CDC7	1.03211722
46	CSNK1G2	1.01768386
47	MKNK1	1.01666481
48	NME1	0.98330015
49	MAP3K4	0.95383116
50	PDK2	0.94358403
51	STK39	0.93074403
52	EIF2AK2	0.92939287
53	STK3	0.92067398
54	CSNK1G3	0.91911756
55	NTRK3	0.88524693
56	INSRR	0.87743977
57	FGFR2	0.87083824
58	BCR	0.83881229
59	NEK6	0.82934103
60	WNK4	0.81597328
61	PKN1	0.75845366
62	MAP2K4	0.75406408
63	PIK3CG	0.72214859
64	MAPK15	0.71012713
65	MAP2K7	0.66809942
66	CSNK1A1L	0.65965458
67	CDK3	0.63034720
68	PRKCG	0.62915365
69	NEK1	0.62909392
70	IRAK2	0.62874668
71	MAP3K6	0.58235635
72	NEK9	0.57618345
73	PLK1	0.56915067
74	ADRBK1	0.56893006
75	CASK	0.53493586
76	STK38L	0.51121701
77	DYRK3	0.47343803
78	ATR	0.45660126
79	PRKCI	0.45225222
80	NLK	0.44562114
81	LATS1	0.43418003
82	PRKCE	0.43348963
83	MINK1	0.42530726
84	STK4	0.42170742
85	STK16	0.41887907
86	IKBKE	0.41744374
87	BCKDK	0.41085435
88	CHEK2	0.40414342
89	BRD4	0.40313843
90	RPS6KA4	0.37326409
91	KIT	0.36403164
92	STK11	0.36309285
93	CAMKK1	0.35940757
94	FGFR1	0.34904915
95	CAMK1D	0.34812062
96	CDK8	0.32900569
97	PRKCZ	0.32376229
98	GRK7	0.30576148
99	PRKCH	0.30501861
100	FLT3	0.30049774

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	3.31571817
2	Proteasome_Homo sapiens_hsa03050	3.06087194
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.99883069
4	RNA degradation_Homo sapiens_hsa03018	2.79850172
5	Protein export_Homo sapiens_hsa03060	2.77218954
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.63232546
7	RNA polymerase_Homo sapiens_hsa03020	2.53544786
8	Parkinsons disease_Homo sapiens_hsa05012	2.47564566
9	Homologous recombination_Homo sapiens_hsa03440	2.42313247
10	One carbon pool by folate_Homo sapiens_hsa00670	2.31937635
11	Fanconi anemia pathway_Homo sapiens_hsa03460	2.29891682
12	Butanoate metabolism_Homo sapiens_hsa00650	2.20404919
13	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.93991802
14	Caffeine metabolism_Homo sapiens_hsa00232	1.92249616
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.91272320
16	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.90650625
17	Ribosome_Homo sapiens_hsa03010	1.89733172
18	Huntingtons disease_Homo sapiens_hsa05016	1.85661290
19	Steroid biosynthesis_Homo sapiens_hsa00100	1.84943974
20	Nitrogen metabolism_Homo sapiens_hsa00910	1.82110714
21	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.79228400
22	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.70165620
23	Non-homologous end-joining_Homo sapiens_hsa03450	1.60156134
24	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.58284643
25	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.56167850
26	Alzheimers disease_Homo sapiens_hsa05010	1.54972076
27	Propanoate metabolism_Homo sapiens_hsa00640	1.53271116
28	Basal transcription factors_Homo sapiens_hsa03022	1.41590436
29	Tryptophan metabolism_Homo sapiens_hsa00380	1.38335439
30	Mismatch repair_Homo sapiens_hsa03430	1.34215150
31	Cardiac muscle contraction_Homo sapiens_hsa04260	1.32277262
32	Nicotine addiction_Homo sapiens_hsa05033	1.28226025
33	Linoleic acid metabolism_Homo sapiens_hsa00591	1.28036971
34	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.27249538
35	Nucleotide excision repair_Homo sapiens_hsa03420	1.26362183
36	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.19754150
37	Purine metabolism_Homo sapiens_hsa00230	1.18152313
38	Taste transduction_Homo sapiens_hsa04742	1.09783025
39	RNA transport_Homo sapiens_hsa03013	1.04699476
40	Regulation of autophagy_Homo sapiens_hsa04140	1.03897918
41	Circadian rhythm_Homo sapiens_hsa04710	1.03163059
42	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.95548149
43	Peroxisome_Homo sapiens_hsa04146	0.94044713
44	Pyrimidine metabolism_Homo sapiens_hsa00240	0.90986597
45	Lysine degradation_Homo sapiens_hsa00310	0.87938626
46	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.87233025
47	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.85541873
48	Sulfur metabolism_Homo sapiens_hsa00920	0.80638070
49	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.80561371
50	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.78528951
51	p53 signaling pathway_Homo sapiens_hsa04115	0.76039345
52	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.75994857
53	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.75866145
54	Olfactory transduction_Homo sapiens_hsa04740	0.74474999
55	Folate biosynthesis_Homo sapiens_hsa00790	0.73865544
56	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.71192489
57	Glutamatergic synapse_Homo sapiens_hsa04724	0.68786664
58	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.67876201
59	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.67368236
60	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.66252338
61	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.64212963
62	Collecting duct acid secretion_Homo sapiens_hsa04966	0.62814445
63	Selenocompound metabolism_Homo sapiens_hsa00450	0.61558421
64	Morphine addiction_Homo sapiens_hsa05032	0.61350238
65	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.60397128
66	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.60066377
67	Base excision repair_Homo sapiens_hsa03410	0.59416966
68	Spliceosome_Homo sapiens_hsa03040	0.58261853
69	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.56465748
70	Metabolic pathways_Homo sapiens_hsa01100	0.54395900
71	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.50937507
72	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.50471957
73	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.48356647
74	Serotonergic synapse_Homo sapiens_hsa04726	0.47820210
75	Ether lipid metabolism_Homo sapiens_hsa00565	0.47549587
76	Fatty acid elongation_Homo sapiens_hsa00062	0.45258994
77	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.41339604
78	Salivary secretion_Homo sapiens_hsa04970	0.41334196
79	DNA replication_Homo sapiens_hsa03030	0.41306854
80	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.40855832
81	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.40291369
82	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.40224402
83	Calcium signaling pathway_Homo sapiens_hsa04020	0.39529978
84	Fat digestion and absorption_Homo sapiens_hsa04975	0.38948575
85	Circadian entrainment_Homo sapiens_hsa04713	0.37891409
86	mRNA surveillance pathway_Homo sapiens_hsa03015	0.37270854
87	Alcoholism_Homo sapiens_hsa05034	0.36960925
88	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.36776423
89	Pyruvate metabolism_Homo sapiens_hsa00620	0.36770969
90	Rheumatoid arthritis_Homo sapiens_hsa05323	0.36421693
91	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.35880217
92	Cell cycle_Homo sapiens_hsa04110	0.35860167
93	Insulin secretion_Homo sapiens_hsa04911	0.33748415
94	ABC transporters_Homo sapiens_hsa02010	0.33592009
95	Primary immunodeficiency_Homo sapiens_hsa05340	0.32744644
96	GABAergic synapse_Homo sapiens_hsa04727	0.32420324
97	Sphingolipid metabolism_Homo sapiens_hsa00600	0.31395565
98	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.30222716
99	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.28649306
100	Dopaminergic synapse_Homo sapiens_hsa04728	0.28361943

HMGB1P14

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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