HMGB1P14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of protein localization to mitochondrial membrane (GO:0090151)4.76519301
2neural tube formation (GO:0001841)4.32120299
3Notch signaling involved in heart development (GO:0061314)4.24994717
4DNA deamination (GO:0045006)4.16717184
5tachykinin receptor signaling pathway (GO:0007217)4.12551232
6regulation of timing of cell differentiation (GO:0048505)4.12228869
7retinal cone cell development (GO:0046549)4.07765414
8epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.95853258
9regulation of development, heterochronic (GO:0040034)3.91419795
10nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.69738262
11behavioral response to nicotine (GO:0035095)3.69329430
12exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.65035393
13auditory receptor cell differentiation (GO:0042491)3.63213615
14epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.50335431
15protein complex biogenesis (GO:0070271)3.44867120
16detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.43125951
17mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.41663949
18mitochondrial respiratory chain complex I assembly (GO:0032981)3.41663949
19NADH dehydrogenase complex assembly (GO:0010257)3.41663949
20kinetochore assembly (GO:0051382)3.30400304
21kinetochore organization (GO:0051383)3.23473084
22regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.21900132
23water-soluble vitamin biosynthetic process (GO:0042364)3.21320141
24adaptation of signaling pathway (GO:0023058)3.20319557
25positive regulation of action potential (GO:0045760)3.18564373
26protein neddylation (GO:0045116)3.17436821
27mitochondrial respiratory chain complex assembly (GO:0033108)3.14437465
28detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.13316922
29negative regulation of DNA-dependent DNA replication (GO:2000104)3.06362542
30energy coupled proton transport, down electrochemical gradient (GO:0015985)3.05231358
31ATP synthesis coupled proton transport (GO:0015986)3.05231358
32nonmotile primary cilium assembly (GO:0035058)3.04528128
33rRNA modification (GO:0000154)3.04444696
34dopamine transport (GO:0015872)3.03059195
35hepatocyte apoptotic process (GO:0097284)3.02151948
36spinal cord association neuron differentiation (GO:0021527)2.99756630
37mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.99456401
38head development (GO:0060322)2.99093750
39replication fork processing (GO:0031297)2.96660865
40regulation of energy homeostasis (GO:2000505)2.94241627
41negative regulation of transcription regulatory region DNA binding (GO:2000678)2.93242626
42regulation of cilium movement (GO:0003352)2.92853532
43RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.90068911
44positive regulation of prostaglandin secretion (GO:0032308)2.86891532
45negative regulation of telomere maintenance (GO:0032205)2.86434358
46chromatin remodeling at centromere (GO:0031055)2.85783883
47pyrimidine nucleobase catabolic process (GO:0006208)2.84705661
48protein polyglutamylation (GO:0018095)2.83796000
49regulation of action potential (GO:0098900)2.82659901
50chaperone-mediated protein transport (GO:0072321)2.82217977
51response to pheromone (GO:0019236)2.77383101
52platelet dense granule organization (GO:0060155)2.76874904
53respiratory chain complex IV assembly (GO:0008535)2.76733357
54detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.72399483
55cilium morphogenesis (GO:0060271)2.70307788
56L-fucose catabolic process (GO:0042355)2.69613851
57fucose catabolic process (GO:0019317)2.69613851
58L-fucose metabolic process (GO:0042354)2.69613851
59regulation of rhodopsin mediated signaling pathway (GO:0022400)2.69036975
60olfactory bulb development (GO:0021772)2.68958956
61epithelial cilium movement (GO:0003351)2.68868178
62regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.67901525
63cell proliferation in forebrain (GO:0021846)2.66690249
64DNA demethylation (GO:0080111)2.66456670
65cell wall macromolecule catabolic process (GO:0016998)2.64772703
66rhodopsin mediated signaling pathway (GO:0016056)2.64618624
67recombinational repair (GO:0000725)2.64260901
68CENP-A containing nucleosome assembly (GO:0034080)2.63540211
69behavioral response to ethanol (GO:0048149)2.62533166
70somite development (GO:0061053)2.61397740
71somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.59742762
72somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.59742762
73isotype switching (GO:0045190)2.59742762
74nucleobase biosynthetic process (GO:0046112)2.59284317
75protein-cofactor linkage (GO:0018065)2.59253997
76positive regulation of cell fate commitment (GO:0010455)2.57069375
77cilium movement (GO:0003341)2.57022742
78peroxisome fission (GO:0016559)2.56563120
79piRNA metabolic process (GO:0034587)2.55303925
80double-strand break repair via homologous recombination (GO:0000724)2.55212124
81rRNA methylation (GO:0031167)2.55000976
82mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.54984061
83protein K6-linked ubiquitination (GO:0085020)2.54743652
84negative regulation of DNA recombination (GO:0045910)2.54545135
85axoneme assembly (GO:0035082)2.52347311
86substrate-independent telencephalic tangential migration (GO:0021826)2.52212475
87substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.52212475
88L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.51788433
89telomere maintenance via telomerase (GO:0007004)2.50657477
90ventricular trabecula myocardium morphogenesis (GO:0003222)2.50421683
91forebrain neuron differentiation (GO:0021879)2.49343429
92cardiac left ventricle morphogenesis (GO:0003214)2.47549520
93aggressive behavior (GO:0002118)2.46260187
94tongue development (GO:0043586)2.45795114
95photoreceptor cell development (GO:0042461)2.44813411
96regulation of immunoglobulin secretion (GO:0051023)2.44198624
97protein localization to cilium (GO:0061512)2.43036294
98synaptic transmission, cholinergic (GO:0007271)2.39786973
99intracellular protein transmembrane import (GO:0044743)2.39161448
100cilium or flagellum-dependent cell motility (GO:0001539)2.38189450

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.23711919
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.00576619
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.00380334
4ZNF274_21170338_ChIP-Seq_K562_Hela3.00278887
5GABP_17652178_ChIP-ChIP_JURKAT_Human2.86253496
6IGF1R_20145208_ChIP-Seq_DFB_Human2.78432581
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.77950994
8VDR_22108803_ChIP-Seq_LS180_Human2.75586440
9GBX2_23144817_ChIP-Seq_PC3_Human2.70838238
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.64749985
11EWS_26573619_Chip-Seq_HEK293_Human2.59681646
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.46504418
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.45333618
14FUS_26573619_Chip-Seq_HEK293_Human2.44887804
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.35220806
16TAF15_26573619_Chip-Seq_HEK293_Human2.33964823
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.28625077
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.28293354
19ELK1_19687146_ChIP-ChIP_HELA_Human2.25409007
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.09650459
21CTBP1_25329375_ChIP-Seq_LNCAP_Human2.02676162
22PCGF2_27294783_Chip-Seq_ESCs_Mouse2.01904994
23E2F4_17652178_ChIP-ChIP_JURKAT_Human2.01818291
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.01709853
25P300_19829295_ChIP-Seq_ESCs_Human1.96989607
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.93740834
27PCGF2_27294783_Chip-Seq_NPCs_Mouse1.93310731
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.91105439
29EZH2_22144423_ChIP-Seq_EOC_Human1.71999860
30VDR_23849224_ChIP-Seq_CD4+_Human1.70398035
31AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.67019187
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.61228944
33ER_23166858_ChIP-Seq_MCF-7_Human1.59902717
34MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.59159012
35POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.55779988
36TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55779988
37SMAD4_21799915_ChIP-Seq_A2780_Human1.53136027
38CBP_20019798_ChIP-Seq_JUKART_Human1.49441062
39IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49441062
40MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.47499820
41TP53_22573176_ChIP-Seq_HFKS_Human1.46712021
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.43295688
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.43078779
44E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.42479259
45SUZ12_27294783_Chip-Seq_NPCs_Mouse1.41951220
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.41422490
47OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40434122
48STAT3_23295773_ChIP-Seq_U87_Human1.37594250
49UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37344916
50IRF1_19129219_ChIP-ChIP_H3396_Human1.34597757
51MYC_18940864_ChIP-ChIP_HL60_Human1.32276550
52POU5F1_16153702_ChIP-ChIP_HESCs_Human1.32121079
53NANOG_19829295_ChIP-Seq_ESCs_Human1.31584510
54SOX2_19829295_ChIP-Seq_ESCs_Human1.31584510
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30432475
56GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.30071393
57KLF5_20875108_ChIP-Seq_MESCs_Mouse1.28420686
58RNF2_27304074_Chip-Seq_NSC_Mouse1.28164182
59TCF4_22108803_ChIP-Seq_LS180_Human1.27327768
60P53_22387025_ChIP-Seq_ESCs_Mouse1.26723976
61NFE2_27457419_Chip-Seq_LIVER_Mouse1.25385382
62NANOG_18555785_Chip-Seq_ESCs_Mouse1.25290981
63EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.25267039
64AR_25329375_ChIP-Seq_VCAP_Human1.25185676
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23681136
66SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23453668
67PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22288702
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22188661
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21730185
70SMAD_19615063_ChIP-ChIP_OVARY_Human1.20951705
71EZH2_27294783_Chip-Seq_NPCs_Mouse1.20092479
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.19713158
73GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17803525
74ELF1_17652178_ChIP-ChIP_JURKAT_Human1.17016232
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.16576716
76RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15996425
77TCF4_23295773_ChIP-Seq_U87_Human1.15434138
78ETS1_20019798_ChIP-Seq_JURKAT_Human1.14039984
79RXR_22108803_ChIP-Seq_LS180_Human1.12082363
80E2F1_18555785_Chip-Seq_ESCs_Mouse1.10595294
81NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10519983
82BCAT_22108803_ChIP-Seq_LS180_Human1.09718064
83FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.08008034
84RUNX2_22187159_ChIP-Seq_PCA_Human1.05389228
85NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.05228807
86STAT3_18555785_Chip-Seq_ESCs_Mouse1.03780242
87SMAD4_21741376_ChIP-Seq_EPCs_Human1.03351470
88FLI1_21867929_ChIP-Seq_TH2_Mouse1.02470151
89CRX_20693478_ChIP-Seq_RETINA_Mouse1.02448479
90TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.00978589
91FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00474086
92FOXA1_25329375_ChIP-Seq_VCAP_Human1.00474086
93PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00133900
94PRDM14_20953172_ChIP-Seq_ESCs_Human0.99557563
95SUZ12_18555785_Chip-Seq_ESCs_Mouse0.99475505
96TP63_19390658_ChIP-ChIP_HaCaT_Human0.99254996
97AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99083360
98CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98689326
99P300_18555785_Chip-Seq_ESCs_Mouse0.98308888
100CMYC_18555785_Chip-Seq_ESCs_Mouse0.97635169

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002736_abnormal_nociception_after3.46221077
2MP0000569_abnormal_digit_pigmentation3.41834692
3MP0002102_abnormal_ear_morphology3.32602266
4MP0001529_abnormal_vocalization3.03038407
5MP0000372_irregular_coat_pigmentation2.94817248
6MP0008877_abnormal_DNA_methylation2.83777593
7MP0006292_abnormal_olfactory_placode2.76242230
8MP0001968_abnormal_touch/_nociception2.64931921
9MP0003252_abnormal_bile_duct2.56089936
10MP0003880_abnormal_central_pattern2.52602333
11MP0001984_abnormal_olfaction2.29790008
12MP0005645_abnormal_hypothalamus_physiol2.27166552
13MP0002938_white_spotting2.26698228
14MP0005084_abnormal_gallbladder_morpholo2.20397494
15MP0005367_renal/urinary_system_phenotyp2.16640186
16MP0000516_abnormal_urinary_system2.16640186
17MP0002837_dystrophic_cardiac_calcinosis2.13269719
18MP0002928_abnormal_bile_duct2.07864986
19MP0006072_abnormal_retinal_apoptosis1.98885667
20MP0004142_abnormal_muscle_tone1.98871092
21MP0008789_abnormal_olfactory_epithelium1.86452360
22MP0005646_abnormal_pituitary_gland1.79951784
23MP0008058_abnormal_DNA_repair1.74033012
24MP0005551_abnormal_eye_electrophysiolog1.72086010
25MP0002095_abnormal_skin_pigmentation1.71499414
26MP0005253_abnormal_eye_physiology1.60407926
27MP0000427_abnormal_hair_cycle1.58534645
28MP0000778_abnormal_nervous_system1.58352770
29MP0002735_abnormal_chemical_nociception1.56547559
30MP0003787_abnormal_imprinting1.55220024
31MP0001293_anophthalmia1.53861905
32MP0003195_calcinosis1.53484902
33MP0005174_abnormal_tail_pigmentation1.50734295
34MP0005394_taste/olfaction_phenotype1.45939501
35MP0005499_abnormal_olfactory_system1.45939501
36MP0003646_muscle_fatigue1.45850368
37MP0001485_abnormal_pinna_reflex1.41024066
38MP0000647_abnormal_sebaceous_gland1.40917153
39MP0009697_abnormal_copulation1.39705955
40MP0004147_increased_porphyrin_level1.37244595
41MP0008872_abnormal_physiological_respon1.33251816
42MP0001486_abnormal_startle_reflex1.32234950
43MP0000685_abnormal_immune_system1.32049567
44MP0002138_abnormal_hepatobiliary_system1.31075292
45MP0009780_abnormal_chondrocyte_physiolo1.25294176
46MP0005075_abnormal_melanosome_morpholog1.20947905
47MP0005187_abnormal_penis_morphology1.20660326
48MP0004133_heterotaxia1.20438773
49MP0009745_abnormal_behavioral_response1.18202848
50MP0004145_abnormal_muscle_electrophysio1.12693321
51MP0008875_abnormal_xenobiotic_pharmacok1.10400808
52MP0000631_abnormal_neuroendocrine_gland1.10249205
53MP0004742_abnormal_vestibular_system1.09158190
54MP0002557_abnormal_social/conspecific_i1.08715808
55MP0002234_abnormal_pharynx_morphology1.08200795
56MP0002067_abnormal_sensory_capabilities1.07645111
57MP0005195_abnormal_posterior_eye1.06735671
58MP0003567_abnormal_fetal_cardiomyocyte1.06658023
59MP0004885_abnormal_endolymph1.06431571
60MP0010094_abnormal_chromosome_stability1.04973050
61MP0002272_abnormal_nervous_system1.04732583
62MP0002233_abnormal_nose_morphology1.04172740
63MP0004215_abnormal_myocardial_fiber1.02723298
64MP0001440_abnormal_grooming_behavior1.01563630
65MP0002751_abnormal_autonomic_nervous1.00818777
66MP0006054_spinal_hemorrhage1.00481793
67MP0003937_abnormal_limbs/digits/tail_de0.96174124
68MP0005391_vision/eye_phenotype0.95334823
69MP0003755_abnormal_palate_morphology0.93124542
70MP0008057_abnormal_DNA_replication0.92973795
71MP0009379_abnormal_foot_pigmentation0.92088716
72MP0002160_abnormal_reproductive_system0.90114347
73MP0002277_abnormal_respiratory_mucosa0.89441731
74MP0008775_abnormal_heart_ventricle0.89055028
75MP0001286_abnormal_eye_development0.88981187
76MP0001970_abnormal_pain_threshold0.86477637
77MP0000049_abnormal_middle_ear0.85296638
78MP0002734_abnormal_mechanical_nocicepti0.84361927
79MP0002572_abnormal_emotion/affect_behav0.84270019
80MP0002752_abnormal_somatic_nervous0.84150836
81MP0008007_abnormal_cellular_replicative0.82653774
82MP0004924_abnormal_behavior0.82578419
83MP0005386_behavior/neurological_phenoty0.82578419
84MP0003718_maternal_effect0.80759973
85MP0009046_muscle_twitch0.78286069
86MP0005085_abnormal_gallbladder_physiolo0.77504625
87MP0003786_premature_aging0.76816973
88MP0001929_abnormal_gametogenesis0.75248621
89MP0002733_abnormal_thermal_nociception0.74236372
90MP0002396_abnormal_hematopoietic_system0.69847226
91MP0009764_decreased_sensitivity_to0.68388332
92MP0000538_abnormal_urinary_bladder0.68114868
93MP0003698_abnormal_male_reproductive0.66856356
94MP0005389_reproductive_system_phenotype0.66628233
95MP0003890_abnormal_embryonic-extraembry0.66021245
96MP0005410_abnormal_fertilization0.65558984
97MP0001188_hyperpigmentation0.64904558
98MP0001835_abnormal_antigen_presentation0.64428870
99MP0000026_abnormal_inner_ear0.62050101
100MP0002876_abnormal_thyroid_physiology0.61989793

Predicted human phenotypes

RankGene SetZ-score
1Type II lissencephaly (HP:0007260)4.39606577
2Abnormality of midbrain morphology (HP:0002418)3.93108869
3Molar tooth sign on MRI (HP:0002419)3.93108869
4Pancreatic cysts (HP:0001737)3.73973749
5True hermaphroditism (HP:0010459)3.68217152
6Pancreatic fibrosis (HP:0100732)3.67379100
7Acute necrotizing encephalopathy (HP:0006965)3.64484326
8Medial flaring of the eyebrow (HP:0010747)3.47780360
9Progressive macrocephaly (HP:0004481)3.36036743
10Fair hair (HP:0002286)3.18978459
11Hypoplasia of the pons (HP:0012110)3.14278515
12Abnormal mitochondria in muscle tissue (HP:0008316)3.03992568
13Abnormality of the pons (HP:0007361)3.00976971
14Acute encephalopathy (HP:0006846)2.95640535
15Gait imbalance (HP:0002141)2.90144154
16Lissencephaly (HP:0001339)2.88182621
17Abnormality of the renal cortex (HP:0011035)2.86810062
18Mitochondrial inheritance (HP:0001427)2.81502144
19Cerebellar dysplasia (HP:0007033)2.74921135
20Septo-optic dysplasia (HP:0100842)2.73276436
21Retinal dysplasia (HP:0007973)2.73066289
22Congenital primary aphakia (HP:0007707)2.71880439
23Increased CSF lactate (HP:0002490)2.71766760
24Abnormality of the renal medulla (HP:0100957)2.64324506
25Intestinal atresia (HP:0011100)2.62824908
26Hypoplastic iliac wings (HP:0002866)2.53190032
27Increased hepatocellular lipid droplets (HP:0006565)2.51086388
28Abnormality of the labia minora (HP:0012880)2.48225512
29Nephronophthisis (HP:0000090)2.45916434
30Absent rod-and cone-mediated responses on ERG (HP:0007688)2.40347979
31Postaxial foot polydactyly (HP:0001830)2.40208806
32Chronic hepatic failure (HP:0100626)2.37361816
33Aplasia/Hypoplasia of the tongue (HP:0010295)2.36073752
34Nephrogenic diabetes insipidus (HP:0009806)2.33262153
35Lipid accumulation in hepatocytes (HP:0006561)2.32466272
36Chorioretinal atrophy (HP:0000533)2.31718541
37Optic nerve hypoplasia (HP:0000609)2.31104738
38Attenuation of retinal blood vessels (HP:0007843)2.24449245
39Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.22874070
40Abnormal rod and cone electroretinograms (HP:0008323)2.22104769
41Thyroiditis (HP:0100646)2.21824736
42Congenital, generalized hypertrichosis (HP:0004540)2.21280229
43Renal cortical cysts (HP:0000803)2.19974986
44Optic disc pallor (HP:0000543)2.18228851
45Postaxial hand polydactyly (HP:0001162)2.16509571
46Congenital hepatic fibrosis (HP:0002612)2.14363927
47Generalized hypopigmentation of hair (HP:0011358)2.09806157
48Congenital stationary night blindness (HP:0007642)2.08190047
49Tubular atrophy (HP:0000092)2.07667145
50Genital tract atresia (HP:0001827)2.07307831
51Abnormality of the metopic suture (HP:0005556)2.07281059
52Abnormal hair whorl (HP:0010721)2.06885076
53Vaginal atresia (HP:0000148)2.06363645
54Hyperglycinemia (HP:0002154)2.03646353
55Dandy-Walker malformation (HP:0001305)2.03582433
56Keratoconus (HP:0000563)2.02991313
57Increased corneal curvature (HP:0100692)2.02991313
58Disproportionate short-trunk short stature (HP:0003521)2.02914214
59Cystic liver disease (HP:0006706)2.02428748
60Progressive cerebellar ataxia (HP:0002073)1.98498704
61Constricted visual fields (HP:0001133)1.97027376
62Hypoproteinemia (HP:0003075)1.96287086
63Methylmalonic acidemia (HP:0002912)1.95939359
64Rhinitis (HP:0012384)1.94202240
65Pendular nystagmus (HP:0012043)1.93666888
66Abolished electroretinogram (ERG) (HP:0000550)1.90896511
67Aplasia/Hypoplasia of the spleen (HP:0010451)1.89255997
68Prominent metopic ridge (HP:0005487)1.88703209
69Poor coordination (HP:0002370)1.87690205
70Rib fusion (HP:0000902)1.86844662
71Bony spicule pigmentary retinopathy (HP:0007737)1.86018182
723-Methylglutaconic aciduria (HP:0003535)1.85018489
73Progressive inability to walk (HP:0002505)1.84799995
74Sclerocornea (HP:0000647)1.84057690
75Colon cancer (HP:0003003)1.83656387
76Aganglionic megacolon (HP:0002251)1.82951014
77Anencephaly (HP:0002323)1.82659455
78Cerebral edema (HP:0002181)1.81800126
79Bilateral microphthalmos (HP:0007633)1.78985820
80Renal Fanconi syndrome (HP:0001994)1.78606400
81Oligodactyly (hands) (HP:0001180)1.74762506
82Adactyly (HP:0009776)1.74482383
83Prominent nasal bridge (HP:0000426)1.74090166
84Abnormality of B cell number (HP:0010975)1.73544971
85Male pseudohermaphroditism (HP:0000037)1.73533783
86Ectopic kidney (HP:0000086)1.73525439
87Leukodystrophy (HP:0002415)1.73357142
88Narrow forehead (HP:0000341)1.73127429
89Oligodactyly (HP:0012165)1.72280145
90Hepatocellular necrosis (HP:0001404)1.72214729
91Small hand (HP:0200055)1.71288565
92Congenital sensorineural hearing impairment (HP:0008527)1.70892045
93B lymphocytopenia (HP:0010976)1.69398582
94Abnormality of the ileum (HP:0001549)1.68432540
95Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.67680115
96Gaze-evoked nystagmus (HP:0000640)1.67196153
97Progressive microcephaly (HP:0000253)1.66278804
98Pachygyria (HP:0001302)1.64748832
99Abnormal respiratory motile cilium morphology (HP:0005938)1.64725381
100Abnormal respiratory epithelium morphology (HP:0012253)1.64725381

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.64681259
2MAP4K22.88206941
3NUAK12.55874202
4TNIK2.47121181
5TXK2.31510359
6MAPK132.28372876
7TSSK62.22829629
8WNK31.98733517
9CAMKK21.93322335
10MAP3K121.91615413
11ZAK1.90736285
12EIF2AK31.81568823
13VRK11.63233061
14PNCK1.61388740
15PAK31.60952947
16BMPR1B1.51951978
17TAOK31.49842303
18IRAK11.49269697
19PLK21.48195273
20ADRBK21.46164921
21PIK3CA1.45422615
22TLK11.42866565
23PINK11.41968421
24BRSK21.40064650
25TAF11.39688967
26PLK31.38166520
27EIF2AK11.36698580
28MST41.36360422
29EPHA41.33250162
30DYRK21.25973420
31GRK11.25361126
32AKT31.21599227
33ACVR1B1.21111222
34TRIM281.20919069
35PLK41.18782306
36WEE11.18665575
37VRK21.16562404
38DAPK21.16132486
39ERBB31.15763130
40MKNK21.14566891
41BUB11.10696309
42OXSR11.07193723
43MARK11.03391331
44CSNK1G11.03362242
45CDC71.03211722
46CSNK1G21.01768386
47MKNK11.01666481
48NME10.98330015
49MAP3K40.95383116
50PDK20.94358403
51STK390.93074403
52EIF2AK20.92939287
53STK30.92067398
54CSNK1G30.91911756
55NTRK30.88524693
56INSRR0.87743977
57FGFR20.87083824
58BCR0.83881229
59NEK60.82934103
60WNK40.81597328
61PKN10.75845366
62MAP2K40.75406408
63PIK3CG0.72214859
64MAPK150.71012713
65MAP2K70.66809942
66CSNK1A1L0.65965458
67CDK30.63034720
68PRKCG0.62915365
69NEK10.62909392
70IRAK20.62874668
71MAP3K60.58235635
72NEK90.57618345
73PLK10.56915067
74ADRBK10.56893006
75CASK0.53493586
76STK38L0.51121701
77DYRK30.47343803
78ATR0.45660126
79PRKCI0.45225222
80NLK0.44562114
81LATS10.43418003
82PRKCE0.43348963
83MINK10.42530726
84STK40.42170742
85STK160.41887907
86IKBKE0.41744374
87BCKDK0.41085435
88CHEK20.40414342
89BRD40.40313843
90RPS6KA40.37326409
91KIT0.36403164
92STK110.36309285
93CAMKK10.35940757
94FGFR10.34904915
95CAMK1D0.34812062
96CDK80.32900569
97PRKCZ0.32376229
98GRK70.30576148
99PRKCH0.30501861
100FLT30.30049774

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.31571817
2Proteasome_Homo sapiens_hsa030503.06087194
3Oxidative phosphorylation_Homo sapiens_hsa001902.99883069
4RNA degradation_Homo sapiens_hsa030182.79850172
5Protein export_Homo sapiens_hsa030602.77218954
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.63232546
7RNA polymerase_Homo sapiens_hsa030202.53544786
8Parkinsons disease_Homo sapiens_hsa050122.47564566
9Homologous recombination_Homo sapiens_hsa034402.42313247
10One carbon pool by folate_Homo sapiens_hsa006702.31937635
11Fanconi anemia pathway_Homo sapiens_hsa034602.29891682
12Butanoate metabolism_Homo sapiens_hsa006502.20404919
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.93991802
14Caffeine metabolism_Homo sapiens_hsa002321.92249616
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.91272320
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.90650625
17Ribosome_Homo sapiens_hsa030101.89733172
18Huntingtons disease_Homo sapiens_hsa050161.85661290
19Steroid biosynthesis_Homo sapiens_hsa001001.84943974
20Nitrogen metabolism_Homo sapiens_hsa009101.82110714
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.79228400
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.70165620
23Non-homologous end-joining_Homo sapiens_hsa034501.60156134
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.58284643
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.56167850
26Alzheimers disease_Homo sapiens_hsa050101.54972076
27Propanoate metabolism_Homo sapiens_hsa006401.53271116
28Basal transcription factors_Homo sapiens_hsa030221.41590436
29Tryptophan metabolism_Homo sapiens_hsa003801.38335439
30Mismatch repair_Homo sapiens_hsa034301.34215150
31Cardiac muscle contraction_Homo sapiens_hsa042601.32277262
32Nicotine addiction_Homo sapiens_hsa050331.28226025
33Linoleic acid metabolism_Homo sapiens_hsa005911.28036971
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.27249538
35Nucleotide excision repair_Homo sapiens_hsa034201.26362183
36Vitamin B6 metabolism_Homo sapiens_hsa007501.19754150
37Purine metabolism_Homo sapiens_hsa002301.18152313
38Taste transduction_Homo sapiens_hsa047421.09783025
39RNA transport_Homo sapiens_hsa030131.04699476
40Regulation of autophagy_Homo sapiens_hsa041401.03897918
41Circadian rhythm_Homo sapiens_hsa047101.03163059
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.95548149
43Peroxisome_Homo sapiens_hsa041460.94044713
44Pyrimidine metabolism_Homo sapiens_hsa002400.90986597
45Lysine degradation_Homo sapiens_hsa003100.87938626
46Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.87233025
47Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.85541873
48Sulfur metabolism_Homo sapiens_hsa009200.80638070
49Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.80561371
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.78528951
51p53 signaling pathway_Homo sapiens_hsa041150.76039345
52NOD-like receptor signaling pathway_Homo sapiens_hsa046210.75994857
53Primary bile acid biosynthesis_Homo sapiens_hsa001200.75866145
54Olfactory transduction_Homo sapiens_hsa047400.74474999
55Folate biosynthesis_Homo sapiens_hsa007900.73865544
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71192489
57Glutamatergic synapse_Homo sapiens_hsa047240.68786664
58Intestinal immune network for IgA production_Homo sapiens_hsa046720.67876201
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.67368236
60Systemic lupus erythematosus_Homo sapiens_hsa053220.66252338
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64212963
62Collecting duct acid secretion_Homo sapiens_hsa049660.62814445
63Selenocompound metabolism_Homo sapiens_hsa004500.61558421
64Morphine addiction_Homo sapiens_hsa050320.61350238
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60397128
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.60066377
67Base excision repair_Homo sapiens_hsa034100.59416966
68Spliceosome_Homo sapiens_hsa030400.58261853
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.56465748
70Metabolic pathways_Homo sapiens_hsa011000.54395900
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.50937507
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50471957
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48356647
74Serotonergic synapse_Homo sapiens_hsa047260.47820210
75Ether lipid metabolism_Homo sapiens_hsa005650.47549587
76Fatty acid elongation_Homo sapiens_hsa000620.45258994
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.41339604
78Salivary secretion_Homo sapiens_hsa049700.41334196
79DNA replication_Homo sapiens_hsa030300.41306854
80Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.40855832
81Arachidonic acid metabolism_Homo sapiens_hsa005900.40291369
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40224402
83Calcium signaling pathway_Homo sapiens_hsa040200.39529978
84Fat digestion and absorption_Homo sapiens_hsa049750.38948575
85Circadian entrainment_Homo sapiens_hsa047130.37891409
86mRNA surveillance pathway_Homo sapiens_hsa030150.37270854
87Alcoholism_Homo sapiens_hsa050340.36960925
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36776423
89Pyruvate metabolism_Homo sapiens_hsa006200.36770969
90Rheumatoid arthritis_Homo sapiens_hsa053230.36421693
91Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.35880217
92Cell cycle_Homo sapiens_hsa041100.35860167
93Insulin secretion_Homo sapiens_hsa049110.33748415
94ABC transporters_Homo sapiens_hsa020100.33592009
95Primary immunodeficiency_Homo sapiens_hsa053400.32744644
96GABAergic synapse_Homo sapiens_hsa047270.32420324
97Sphingolipid metabolism_Homo sapiens_hsa006000.31395565
98Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.30222716
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.28649306
100Dopaminergic synapse_Homo sapiens_hsa047280.28361943

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »