HMGA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)4.69865967
2paraxial mesoderm development (GO:0048339)4.47792667
3nuclear pore complex assembly (GO:0051292)4.04665893
4kinetochore organization (GO:0051383)4.02778214
5nuclear pore organization (GO:0006999)3.99412812
6mitotic sister chromatid cohesion (GO:0007064)3.93327739
7protein localization to kinetochore (GO:0034501)3.82142649
8pre-miRNA processing (GO:0031054)3.72906336
9mitotic metaphase plate congression (GO:0007080)3.70673718
10establishment of integrated proviral latency (GO:0075713)3.64037980
11regulation of spindle organization (GO:0090224)3.63724218
12hippo signaling (GO:0035329)3.53152641
13convergent extension (GO:0060026)3.52141461
14outer ear morphogenesis (GO:0042473)3.51499651
15* heterochromatin organization (GO:0070828)3.51090707
16kinetochore assembly (GO:0051382)3.47149046
17regulation of sister chromatid cohesion (GO:0007063)3.38320140
18notochord development (GO:0030903)3.37879340
19metaphase plate congression (GO:0051310)3.36884384
20regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.35471084
21regulation of mitotic spindle organization (GO:0060236)3.31789487
22mitotic nuclear envelope disassembly (GO:0007077)3.29530377
23regulation of gene silencing by RNA (GO:0060966)3.28664087
24regulation of posttranscriptional gene silencing (GO:0060147)3.28664087
25regulation of gene silencing by miRNA (GO:0060964)3.28664087
26pore complex assembly (GO:0046931)3.12994046
27glucocorticoid receptor signaling pathway (GO:0042921)3.11205643
28embryonic foregut morphogenesis (GO:0048617)3.10123132
29protein localization to chromosome, centromeric region (GO:0071459)3.10078522
30membrane disassembly (GO:0030397)3.09403048
31nuclear envelope disassembly (GO:0051081)3.09403048
32dorsal/ventral axis specification (GO:0009950)3.09043329
33formation of translation preinitiation complex (GO:0001731)3.09022188
34sister chromatid segregation (GO:0000819)3.07873620
35regulation of non-canonical Wnt signaling pathway (GO:2000050)3.06501829
36lateral sprouting from an epithelium (GO:0060601)3.05202680
37mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.98126642
38anterior/posterior axis specification, embryo (GO:0008595)2.98125026
39Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.96923640
40regulation of heart morphogenesis (GO:2000826)2.96694286
41mesenchymal-epithelial cell signaling (GO:0060638)2.95497789
42regulation of mitotic metaphase/anaphase transition (GO:0030071)2.94740380
43negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.94663000
44spindle checkpoint (GO:0031577)2.94650859
45body morphogenesis (GO:0010171)2.94575469
46mitotic chromosome condensation (GO:0007076)2.90316535
47mitotic spindle assembly checkpoint (GO:0007094)2.89983096
48establishment of chromosome localization (GO:0051303)2.89873676
49polarized epithelial cell differentiation (GO:0030859)2.89793628
50spindle assembly checkpoint (GO:0071173)2.89749249
51embryonic skeletal joint morphogenesis (GO:0060272)2.89655751
52IMP biosynthetic process (GO:0006188)2.89093062
53mitotic spindle checkpoint (GO:0071174)2.88584988
54DNA replication-dependent nucleosome organization (GO:0034723)2.88248553
55DNA replication-dependent nucleosome assembly (GO:0006335)2.88248553
56DNA replication initiation (GO:0006270)2.88099646
57regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.86748002
58regulation of establishment of planar polarity (GO:0090175)2.86712235
59regulation of RNA export from nucleus (GO:0046831)2.86178444
60negative regulation of chromosome segregation (GO:0051985)2.85860836
61negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.84997358
62negative regulation of sister chromatid segregation (GO:0033046)2.84997358
63negative regulation of mitotic sister chromatid separation (GO:2000816)2.84997358
64negative regulation of mitotic sister chromatid segregation (GO:0033048)2.84997358
65artery development (GO:0060840)2.82778976
66mitotic sister chromatid segregation (GO:0000070)2.81661641
67histone exchange (GO:0043486)2.80868291
68generation of neurons (GO:0048699)2.75634259
69negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.74940840
70negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.74487507
71mesenchymal cell proliferation (GO:0010463)2.72153293
72ventricular cardiac muscle cell development (GO:0055015)2.72068055
73positive regulation of SMAD protein import into nucleus (GO:0060391)2.71731006
74DNA strand elongation involved in DNA replication (GO:0006271)2.70845455
75regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.70106755
76regulation of chromosome segregation (GO:0051983)2.69633714
77bone trabecula formation (GO:0060346)2.68790169
78cell migration involved in sprouting angiogenesis (GO:0002042)2.68372628
79regulation of sister chromatid segregation (GO:0033045)2.68273584
80regulation of mitotic sister chromatid separation (GO:0010965)2.68273584
81regulation of mitotic sister chromatid segregation (GO:0033047)2.68273584
82negative regulation of chondrocyte differentiation (GO:0032331)2.67981092
83DNA duplex unwinding (GO:0032508)2.67577655
84* chondrocyte proliferation (GO:0035988)2.67058307
85CENP-A containing nucleosome assembly (GO:0034080)2.67032671
86DNA geometric change (GO:0032392)2.66794631
87* regulation of cellular senescence (GO:2000772)2.66325867
88positive regulation of mitotic sister chromatid separation (GO:1901970)2.65424228
89positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.65424228
90positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.65424228
91organ formation (GO:0048645)2.64422515
92proximal/distal pattern formation (GO:0009954)2.64185158
93regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.62749506
94regulation of cell fate specification (GO:0042659)2.62697968
95ATP-dependent chromatin remodeling (GO:0043044)2.62689457
96DNA topological change (GO:0006265)2.61962633
97DNA ligation (GO:0006266)2.61810293
98negative regulation of RNA splicing (GO:0033119)2.61499212
99nucleobase biosynthetic process (GO:0046112)2.61212553
100DNA replication-independent nucleosome organization (GO:0034724)2.61165568
101DNA replication-independent nucleosome assembly (GO:0006336)2.61165568
102planar cell polarity pathway involved in neural tube closure (GO:0090179)2.61001347
103mRNA stabilization (GO:0048255)2.60541897
104RNA stabilization (GO:0043489)2.60541897
105DNA strand renaturation (GO:0000733)2.59778885
106cochlea morphogenesis (GO:0090103)2.59663316
107G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.59275641
108positive regulation of chromosome segregation (GO:0051984)2.59192457
109cell proliferation involved in metanephros development (GO:0072203)2.59003116
110positive regulation of epithelial to mesenchymal transition (GO:0010718)2.58796043
111non-canonical Wnt signaling pathway (GO:0035567)2.57978210
112regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.57692760
113sequestering of extracellular ligand from receptor (GO:0035581)2.57165815
114endocardial cushion development (GO:0003197)2.57111658
115regulation of centrosome cycle (GO:0046605)2.55786562
116DNA strand elongation (GO:0022616)2.55371579
117axon extension involved in axon guidance (GO:0048846)2.55307870
118neuron projection extension involved in neuron projection guidance (GO:1902284)2.55307870
119protein localization to chromosome (GO:0034502)2.55231717
120chromatin remodeling at centromere (GO:0031055)2.54163996
121establishment of viral latency (GO:0019043)2.54116766
122DNA replication checkpoint (GO:0000076)2.53463392
123endothelial cell morphogenesis (GO:0001886)2.52238739
124response to X-ray (GO:0010165)2.52227456
125mitotic cytokinesis (GO:0000281)2.51966455
126* regulation of cell aging (GO:0090342)2.51762533
127regulation of centriole replication (GO:0046599)2.51545124
128establishment of apical/basal cell polarity (GO:0035089)2.51180823
129IMP metabolic process (GO:0046040)2.50913097
130regulation of transforming growth factor beta2 production (GO:0032909)2.50784377
1313-UTR-mediated mRNA stabilization (GO:0070935)2.49906284
132mesenchyme development (GO:0060485)2.49687648
133craniofacial suture morphogenesis (GO:0097094)2.49503371
134embryonic cranial skeleton morphogenesis (GO:0048701)2.49458846
135cell adhesion mediated by integrin (GO:0033627)2.43306688
136regulation of helicase activity (GO:0051095)2.40250653
137NLS-bearing protein import into nucleus (GO:0006607)2.38196255
138hemidesmosome assembly (GO:0031581)2.37837285
139lung-associated mesenchyme development (GO:0060484)2.33579372
140regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.30316545
141regulation of hippo signaling (GO:0035330)2.30168413
142* chromosome condensation (GO:0030261)2.29959913
143establishment of monopolar cell polarity (GO:0061162)2.29216968
144establishment or maintenance of monopolar cell polarity (GO:0061339)2.29216968
145inner ear receptor cell development (GO:0060119)2.26631700
146non-recombinational repair (GO:0000726)2.26627720
147double-strand break repair via nonhomologous end joining (GO:0006303)2.26627720
148trophoblast giant cell differentiation (GO:0060707)2.26505985

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.93857437
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.43189666
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.10380765
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.09515819
5RBPJ_22232070_ChIP-Seq_NCS_Mouse4.04046069
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.91652534
7* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.54034286
8AR_21909140_ChIP-Seq_LNCAP_Human3.32056998
9TP63_19390658_ChIP-ChIP_HaCaT_Human3.24064958
10EGR1_19374776_ChIP-ChIP_THP-1_Human3.21718777
11KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.89780913
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.79239399
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.62686871
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.58084383
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.40723952
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.31695384
17E2F1_21310950_ChIP-Seq_MCF-7_Human2.28138952
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.26147714
19* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.08087593
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.05070288
21HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.01455094
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.94012384
23MYC_18358816_ChIP-ChIP_MESCs_Mouse1.87906023
24XRN2_22483619_ChIP-Seq_HELA_Human1.87826455
25CREB1_15753290_ChIP-ChIP_HEK293T_Human1.86262028
26* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.84381257
27TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.79602536
28KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.78746026
29KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.78746026
30KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.78746026
31MYCN_18555785_ChIP-Seq_MESCs_Mouse1.77129094
32ELK1_19687146_ChIP-ChIP_HELA_Human1.76253083
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.75691218
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72679982
35KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.70204704
36TP63_17297297_ChIP-ChIP_HaCaT_Human1.68573321
37EST1_17652178_ChIP-ChIP_JURKAT_Human1.67860344
38TTF2_22483619_ChIP-Seq_HELA_Human1.67067414
39ZFX_18555785_ChIP-Seq_MESCs_Mouse1.66014891
40YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59219631
41SOX2_16153702_ChIP-ChIP_HESCs_Human1.57653695
42CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.55654913
43DCP1A_22483619_ChIP-Seq_HELA_Human1.45876372
44MYC_22102868_ChIP-Seq_BL_Human1.45440654
45TRIM28_21343339_ChIP-Seq_HEK293_Human1.44440337
46CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.43014628
47ETS1_20019798_ChIP-Seq_JURKAT_Human1.42100480
48KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.41975158
49WT1_19549856_ChIP-ChIP_CCG9911_Human1.41306875
50CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.38119899
51E2F1_18555785_ChIP-Seq_MESCs_Mouse1.37355830
52* BRD4_25478319_ChIP-Seq_HGPS_Human1.36549577
53TCF3_18692474_ChIP-Seq_MESCs_Mouse1.34854300
54PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.34583971
55FUS_26573619_Chip-Seq_HEK293_Human1.34360790
56GABP_17652178_ChIP-ChIP_JURKAT_Human1.32075562
57HIF1A_21447827_ChIP-Seq_MCF-7_Human1.31616291
58RARG_19884340_ChIP-ChIP_MEFs_Mouse1.29680113
59NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.27419537
60MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27119859
61SOX2_18555785_ChIP-Seq_MESCs_Mouse1.25628200
62ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.24171171
63GABP_19822575_ChIP-Seq_HepG2_Human1.24071560
64SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.23910237
65* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.23856309
66RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.21243258
67* ISL1_27105846_Chip-Seq_CPCs_Mouse1.18419692
68CHD1_26751641_Chip-Seq_LNCaP_Human1.18010818
69TCF3_18692474_ChIP-Seq_MEFs_Mouse1.16955010
70GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.16909391
71CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.15624353
72HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.14985369
73NANOG_16153702_ChIP-ChIP_HESCs_Human1.14969452
74* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.14477414
75* NANOG_21062744_ChIP-ChIP_HESCs_Human1.14200291
76TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.13766760
77VDR_23849224_ChIP-Seq_CD4+_Human1.13539793
78EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.12178238
79POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.11218906
80TBX3_20139965_ChIP-Seq_ESCs_Mouse1.11094090
81EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.11032000
82NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.10353894
83TBX3_20139965_ChIP-Seq_MESCs_Mouse1.10044949
84CLOCK_20551151_ChIP-Seq_293T_Human1.09476760
85FOXP3_21729870_ChIP-Seq_TREG_Human1.09052979
86SOX17_20123909_ChIP-Seq_XEN_Mouse1.08967767
87MYC_18940864_ChIP-ChIP_HL60_Human1.08600572
88ESR1_15608294_ChIP-ChIP_MCF-7_Human1.08427588
89E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07564548
90KDM5A_27292631_Chip-Seq_BREAST_Human1.06964934
91KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06889041
92SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.06599839
93SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.06533665
94SALL4_18804426_ChIP-ChIP_XEN_Mouse1.06188692
95* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.05732070
96* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.04363969
97* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.03419863
98TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02873124
99* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.02142635
100EWS_26573619_Chip-Seq_HEK293_Human1.01679994
101CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.01345415
102* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01310008
103* SOX9_26525672_Chip-Seq_HEART_Mouse1.00242742
104TFEB_21752829_ChIP-Seq_HELA_Human0.99714930
105CIITA_25753668_ChIP-Seq_RAJI_Human0.99427594
106SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.99207276
107SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.99207276
108FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.98821945
109PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98357603
110NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.97530383
111SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.97463183
112CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.96739518
113SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.94632488
114NANOG_18555785_ChIP-Seq_MESCs_Mouse0.94513245
115POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94308515
116ELK3_25401928_ChIP-Seq_HUVEC_Human0.93377755
117PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.92808907
118* EP300_21415370_ChIP-Seq_HL-1_Mouse0.91847800
119STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.91661810
120THAP11_20581084_ChIP-Seq_MESCs_Mouse0.91556726
121* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.91477891
122* NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.90141716
123DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.90080209
124KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.89889651
125POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.89755092
126CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.89008400
127* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.86826736
128TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.86294927
129NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.84041394
130GATA1_26923725_Chip-Seq_HPCs_Mouse0.82644356
131P300_19829295_ChIP-Seq_ESCs_Human0.81507530

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003123_paternal_imprinting3.98958569
2MP0010030_abnormal_orbit_morphology3.78677117
3MP0003122_maternal_imprinting3.02150202
4MP0009053_abnormal_anal_canal2.90578110
5MP0006292_abnormal_olfactory_placode2.84532142
6MP0003121_genomic_imprinting2.70510911
7MP0003385_abnormal_body_wall2.50806772
8MP0003705_abnormal_hypodermis_morpholog2.48465266
9MP0009250_abnormal_appendicular_skeleto2.31830779
10MP0010352_gastrointestinal_tract_polyps2.19877153
11MP0000537_abnormal_urethra_morphology2.19854584
12MP0004957_abnormal_blastocyst_morpholog2.19072366
13MP0003111_abnormal_nucleus_morphology2.14729261
14MP0010094_abnormal_chromosome_stability2.05286175
15MP0003937_abnormal_limbs/digits/tail_de2.03942163
16MP0003942_abnormal_urinary_system2.02591975
17MP0003077_abnormal_cell_cycle2.02540290
18MP0003693_abnormal_embryo_hatching2.00589987
19MP0005623_abnormal_meninges_morphology1.97830429
20MP0008057_abnormal_DNA_replication1.96944375
21MP0010368_abnormal_lymphatic_system1.93557147
22MP0008438_abnormal_cutaneous_collagen1.90412009
23MP0003941_abnormal_skin_development1.88563377
24MP0003567_abnormal_fetal_cardiomyocyte1.83227115
25MP0008007_abnormal_cellular_replicative1.80667155
26MP0008932_abnormal_embryonic_tissue1.79827960
27MP0000049_abnormal_middle_ear1.77483348
28MP0002938_white_spotting1.73484869
29MP0005503_abnormal_tendon_morphology1.71272149
30MP0002932_abnormal_joint_morphology1.70143908
31MP0000733_abnormal_muscle_development1.66376368
32MP0004197_abnormal_fetal_growth/weight/1.66237758
33MP0003755_abnormal_palate_morphology1.65849194
34MP0002282_abnormal_trachea_morphology1.63399698
35MP0000428_abnormal_craniofacial_morphol1.61223671
36MP0005380_embryogenesis_phenotype1.53608481
37MP0001672_abnormal_embryogenesis/_devel1.53608481
38MP0000534_abnormal_ureter_morphology1.53017480
39MP0003935_abnormal_craniofacial_develop1.49014236
40MP0002085_abnormal_embryonic_tissue1.48880549
41MP0003115_abnormal_respiratory_system1.48685602
42MP0003984_embryonic_growth_retardation1.47899362
43MP0002088_abnormal_embryonic_growth/wei1.47207576
44MP0002084_abnormal_developmental_patter1.46750428
45MP0002249_abnormal_larynx_morphology1.46491085
46MP0001293_anophthalmia1.44691539
47MP0001730_embryonic_growth_arrest1.44258614
48MP0000350_abnormal_cell_proliferation1.41309210
49MP0001697_abnormal_embryo_size1.40652168
50MP0005508_abnormal_skeleton_morphology1.40500885
51MP0003119_abnormal_digestive_system1.39874115
52MP0004272_abnormal_basement_membrane1.37520502
53MP0006054_spinal_hemorrhage1.36745906
54MP0003315_abnormal_perineum_morphology1.35964721
55MP0005076_abnormal_cell_differentiation1.34640645
56MP0003279_aneurysm1.33910285
57MP0005367_renal/urinary_system_phenotyp1.30786456
58MP0000516_abnormal_urinary_system1.30786456
59MP0002086_abnormal_extraembryonic_tissu1.29576997
60* MP0000432_abnormal_head_morphology1.25384502
61MP0001879_abnormal_lymphatic_vessel1.24540734
62MP0003890_abnormal_embryonic-extraembry1.24145959
63MP0003861_abnormal_nervous_system1.23331993
64MP0002116_abnormal_craniofacial_bone1.22958649
65MP0004808_abnormal_hematopoietic_stem1.22359151
66MP0000566_synostosis1.21567783
67* MP0002109_abnormal_limb_morphology1.20597437
68MP0005023_abnormal_wound_healing1.20330023
69* MP0002111_abnormal_tail_morphology1.19530384
70MP0004233_abnormal_muscle_weight1.18826390
71MP0005248_abnormal_Harderian_gland1.17468828
72MP0002114_abnormal_axial_skeleton1.17377055
73MP0004133_heterotaxia1.16856025
74MP0002396_abnormal_hematopoietic_system1.16567755
75MP0000579_abnormal_nail_morphology1.15395927
76MP0008058_abnormal_DNA_repair1.10146998
77MP0000163_abnormal_cartilage_morphology1.09158888
78MP0002233_abnormal_nose_morphology1.08255280
79MP0002080_prenatal_lethality1.07990552
80MP0002925_abnormal_cardiovascular_devel1.06885582
81MP0002115_abnormal_skeleton_extremities1.06505726
82MP0001286_abnormal_eye_development1.05323557
83MP0001299_abnormal_eye_distance/1.04378314
84MP0000762_abnormal_tongue_morphology1.03459569
85MP0003950_abnormal_plasma_membrane1.03070428
86MP0005197_abnormal_uvea_morphology1.02280502
87MP0002113_abnormal_skeleton_development1.01959958
88MP0001849_ear_inflammation0.99354981
89MP0003566_abnormal_cell_adhesion0.97593982
90MP0000767_abnormal_smooth_muscle0.97181082
91MP0002092_abnormal_eye_morphology0.97137345
92MP0002234_abnormal_pharynx_morphology0.96807775
93MP0009384_cardiac_valve_regurgitation0.96591793
94MP0005187_abnormal_penis_morphology0.94964295
95MP0003283_abnormal_digestive_organ0.94876494
96MP0010307_abnormal_tumor_latency0.94444390
97* MP0009703_decreased_birth_body0.92835615
98MP0002697_abnormal_eye_size0.92275110
99MP0001915_intracranial_hemorrhage0.92084361
100MP0003938_abnormal_ear_development0.91114335
101MP0001346_abnormal_lacrimal_gland0.89501608
102MP0000778_abnormal_nervous_system0.89203686
103MP0000569_abnormal_digit_pigmentation0.87304936
104MP0002081_perinatal_lethality0.85327249
105MP0005391_vision/eye_phenotype0.83491590
106* MP0002177_abnormal_outer_ear0.83271032
107* MP0009672_abnormal_birth_weight0.82618686
108MP0008789_abnormal_olfactory_epithelium0.82035560
109MP0005257_abnormal_intraocular_pressure0.81737570
110MP0005275_abnormal_skin_tensile0.81620805
111* MP0002089_abnormal_postnatal_growth/wei0.80725499
112MP0003943_abnormal_hepatobiliary_system0.79948350
113MP0003136_yellow_coat_color0.79028773
114MP0001175_abnormal_lung_morphology0.78959901
115MP0000266_abnormal_heart_morphology0.78815535
116MP0003091_abnormal_cell_migration0.78619384
117MP0001614_abnormal_blood_vessel0.77763293
118MP0001340_abnormal_eyelid_morphology0.76137691
119MP0003718_maternal_effect0.76079879
120MP0001529_abnormal_vocalization0.73378977

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)4.20688144
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.20688144
3Protrusio acetabuli (HP:0003179)3.68697641
4Renal duplication (HP:0000075)3.47497887
5Diastasis recti (HP:0001540)3.30989076
6Abnormality of the 4th metacarpal (HP:0010012)3.30913108
7Premature rupture of membranes (HP:0001788)3.24909309
8Shallow orbits (HP:0000586)3.13466551
9Hepatoblastoma (HP:0002884)3.03295142
10Short middle phalanx of the 5th finger (HP:0004220)3.02586853
11Mesomelia (HP:0003027)2.90915297
12Abnormality of the phalanges of the hallux (HP:0010057)2.87725765
13Broad thumb (HP:0011304)2.79971621
14Short 5th finger (HP:0009237)2.62012498
15Selective tooth agenesis (HP:0001592)2.60486707
16Coronal craniosynostosis (HP:0004440)2.60397820
17Broad toe (HP:0001837)2.52567027
18Asymmetry of the thorax (HP:0001555)2.50326366
19Chromosomal breakage induced by crosslinking agents (HP:0003221)2.49668294
20Nephroblastoma (Wilms tumor) (HP:0002667)2.48772219
21Embryonal renal neoplasm (HP:0011794)2.46465902
22Partial duplication of the phalanx of hand (HP:0009999)2.41954886
23Broad phalanges of the hand (HP:0009768)2.40599346
24Microglossia (HP:0000171)2.38557635
25Chromsome breakage (HP:0040012)2.38208945
26Deviation of the thumb (HP:0009603)2.37251615
27Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.35952790
28Broad phalanx (HP:0006009)2.35824819
29Broad long bones (HP:0005622)2.35255945
30Abnormality of the distal phalanx of the thumb (HP:0009617)2.35171220
31Colon cancer (HP:0003003)2.34177204
32Irregular epiphyses (HP:0010582)2.32974922
33Broad finger (HP:0001500)2.30138499
34Bilateral microphthalmos (HP:0007633)2.28524575
35Hypoplastic pelvis (HP:0008839)2.28470278
36Partial duplication of thumb phalanx (HP:0009944)2.27225377
37Abnormality of the parietal bone (HP:0002696)2.26784318
38Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.24404293
39Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.24234123
40Atresia of the external auditory canal (HP:0000413)2.21567694
41Abnormality of the 2nd finger (HP:0004100)2.19784814
42Cervical subluxation (HP:0003308)2.18124185
43Increased nuchal translucency (HP:0010880)2.15085930
44Proximal placement of thumb (HP:0009623)2.13296508
45Anophthalmia (HP:0000528)2.13211713
46Abnormal umbilical cord blood vessels (HP:0011403)2.13174993
47Single umbilical artery (HP:0001195)2.13174993
48Abnormality of the fetal cardiovascular system (HP:0010948)2.13174993
49Septo-optic dysplasia (HP:0100842)2.08556976
50Duplication of thumb phalanx (HP:0009942)2.08240443
51* Syringomyelia (HP:0003396)2.08064214
52* Spinal cord lesions (HP:0100561)2.08064214
53Increased density of long bones (HP:0006392)2.05361034
54Bifid tongue (HP:0010297)2.05000681
55Soft skin (HP:0000977)2.04593424
56Midline defect of the nose (HP:0004122)2.04553127
57Absent epiphyses (HP:0010577)2.04205120
58Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.04205120
59Neonatal short-limb short stature (HP:0008921)2.02144813
60Abnormality of the calcaneus (HP:0008364)2.00747341
61Natal tooth (HP:0000695)2.00328514
62Abnormality of the phalanges of the 2nd finger (HP:0009541)2.00189265
63Volvulus (HP:0002580)1.99665063
64Esophageal atresia (HP:0002032)1.99247260
65Rectal prolapse (HP:0002035)1.98762821
66Abnormality of the phalanges of the 5th finger (HP:0004213)1.98664924
67High anterior hairline (HP:0009890)1.96883232
68Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.96842052
69Deviation of the hallux (HP:0010051)1.95987795
70Abnormal lung lobation (HP:0002101)1.95662423
71Missing ribs (HP:0000921)1.93856275
72Ectopic kidney (HP:0000086)1.92477711
73Abnormal number of incisors (HP:0011064)1.91913166
74Broad metatarsal (HP:0001783)1.89353745
75Increased number of teeth (HP:0011069)1.88581256
76Medulloblastoma (HP:0002885)1.87646935
77Supernumerary ribs (HP:0005815)1.85628179
78Broad palm (HP:0001169)1.83705520
79Abnormal tarsal ossification (HP:0008369)1.82324093
80Hallux valgus (HP:0001822)1.81902990
81Broad hallux (HP:0010055)1.81358017
82Cutaneous syndactyly (HP:0012725)1.81149286
83Myelomeningocele (HP:0002475)1.80988020
84Aplasia/Hypoplasia of the patella (HP:0006498)1.80950281
85Long eyelashes (HP:0000527)1.79742532
86Abnormality of the umbilical cord (HP:0010881)1.79657962
87Trigonocephaly (HP:0000243)1.79387915
88Vitreoretinal degeneration (HP:0000655)1.78152712
89Patellar aplasia (HP:0006443)1.76621452
90Arterial tortuosity (HP:0005116)1.76559028
91Skull defect (HP:0001362)1.75884513
92Supernumerary bones of the axial skeleton (HP:0009144)1.74698143
93Vertebral clefting (HP:0008428)1.73956733
94Abnormality of the distal phalanges of the toes (HP:0010182)1.73688750
95Capillary hemangiomas (HP:0005306)1.73585692
96Delayed cranial suture closure (HP:0000270)1.73388859
97Abnormal foot bone ossification (HP:0010675)1.72082257
98Carpal synostosis (HP:0009702)1.71916697
99Pterygium (HP:0001059)1.71584028
100Ankle contracture (HP:0006466)1.71521825
101Wrist flexion contracture (HP:0001239)1.71477275
102Abnormality of the proximal phalanges of the hand (HP:0009834)1.70554600
103Abnormality of the incisor (HP:0000676)1.70233937
104Aplasia/Hypoplasia of the sternum (HP:0006714)1.69834505
105Dislocated radial head (HP:0003083)1.68585443
106Preauricular skin tag (HP:0000384)1.68393111
107Meckel diverticulum (HP:0002245)1.67887100
108Aplasia/Hypoplasia of the uvula (HP:0010293)1.67715292
109Cortical dysplasia (HP:0002539)1.67505383
110Supernumerary spleens (HP:0009799)1.67407288
111Rib fusion (HP:0000902)1.67321437
112Aplasia/Hypoplasia of the breasts (HP:0010311)1.67117286
113Rectal fistula (HP:0100590)1.66926575
114Rectovaginal fistula (HP:0000143)1.66926575
115Atrophic scars (HP:0001075)1.66385299
116Thin ribs (HP:0000883)1.65902488
117Abnormality of the middle phalanges of the toes (HP:0010183)1.65843081
118Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.65765721
119Synostosis of carpal bones (HP:0005048)1.65763364
120Gastrointestinal atresia (HP:0002589)1.65294946
121Triphalangeal thumb (HP:0001199)1.64925012
122Aortic aneurysm (HP:0004942)1.64606492
123Abnormal ossification of hand bones (HP:0005921)1.64207196
124Absent radius (HP:0003974)1.63369120
125Wide anterior fontanel (HP:0000260)1.62879134
126Skin tags (HP:0010609)1.62850958
127Preaxial foot polydactyly (HP:0001841)1.62644907
128Cutaneous finger syndactyly (HP:0010554)1.62483702
129Breast aplasia (HP:0100783)1.61788907
130Small intestinal stenosis (HP:0012848)1.61655292
131Duodenal stenosis (HP:0100867)1.61655292
132Bronchomalacia (HP:0002780)1.61637303
133Tracheomalacia (HP:0002779)1.61583159
134Hypoplastic labia majora (HP:0000059)1.61496322
135Abnormality of the radial head (HP:0003995)1.61103281
136Abnormality of the ischium (HP:0003174)1.60839510
137Abnormality of the duodenum (HP:0002246)1.60137976
138Disproportionate tall stature (HP:0001519)1.59700696
139Ulnar bowing (HP:0003031)1.59687700
140Mitral valve prolapse (HP:0001634)1.58959320
141Dilatation of the ascending aorta (HP:0005111)1.58440130
142Epiphyseal dysplasia (HP:0002656)1.58075603
143Hypoplastic ischia (HP:0003175)1.57969884
144Abnormality of the aortic arch (HP:0012303)1.57842891
145Morphological abnormality of the middle ear (HP:0008609)1.57673703
146Limited elbow extension (HP:0001377)1.57614113
147Short middle phalanx of finger (HP:0005819)1.56793898
148Aortic dissection (HP:0002647)1.56071837
149Abnormality of the ileum (HP:0001549)1.55654590
150Abnormality of dentin (HP:0010299)1.55336545
151Adrenal hypoplasia (HP:0000835)1.54973300

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.65673891
2MKNK13.61242246
3LATS13.26393484
4WEE12.72511122
5LATS22.56929124
6CDK122.45044547
7MKNK22.29837851
8NEK22.26326618
9BUB12.21725635
10DDR22.16010681
11BRSK22.06916456
12ERBB42.06867919
13PDGFRA2.02001777
14MAP3K101.97722305
15STK31.96785804
16RPS6KA41.95541543
17ERBB31.94167811
18TNIK1.91882446
19EIF2AK11.89291767
20SRPK11.87842185
21TTK1.83778535
22PLK31.82199151
23PNCK1.80245616
24STK38L1.80143783
25TAF11.74171801
26VRK21.73760500
27PASK1.69939347
28TTN1.63551861
29FLT31.61777487
30TGFBR11.56345679
31PLK11.55766847
32PAK41.53347052
33NTRK11.48764343
34PLK41.46601192
35CDK71.45770682
36FGFR21.44931833
37PKN21.44108721
38TSSK61.42677284
39PAK21.35427800
40PRKD31.34005184
41CDK61.29508554
42MAP3K81.27911512
43NUAK11.27911351
44NEK91.27816619
45AURKB1.27548756
46FGFR11.23352609
47CHEK21.23152578
48CDK81.21334465
49NEK11.20271171
50TRIB31.19857103
51ATR1.14931764
52BRD41.13776024
53EPHB21.13233589
54CAMK1G1.06048286
55CDK41.03583588
56ACVR1B1.01180572
57CHEK11.00998058
58STK101.00444059
59NME20.98510968
60MTOR0.96897538
61TAOK20.93857901
62PBK0.93064053
63BRSK10.91975742
64WNK40.91510737
65ATM0.86637210
66TRIM280.83349916
67EIF2AK20.81635504
68MELK0.80246856
69CDK20.80219687
70TYRO30.80191108
71PTK20.79040021
72TESK10.78996685
73TESK20.78237407
74LIMK10.77638655
75ALK0.76453326
76EPHA20.76308939
77TRPM70.74871375
78PTK60.74091540
79DYRK30.73814406
80BMX0.73391544
81PLK20.69843462
82TIE10.69390325
83SMG10.69292444
84LRRK20.68671629
85* CDK10.65271098
86CAMK1D0.65173927
87BMPR1B0.63114598
88WNK30.62010727
89AURKA0.61852647
90ZAK0.59492632
91EIF2AK30.58121430
92AKT30.57994546
93MAP2K30.54397940
94EEF2K0.54040616
95MAP3K30.53914636
96CSNK1A1L0.53353201
97ILK0.52125975
98DMPK0.51976849
99WNK10.51895233
100CLK10.50803579
101PAK10.50503054
102VRK10.50487607
103CSNK1G10.50448019
104PDGFRB0.49587220
105ERBB20.47806777
106CDK180.47030124
107BRAF0.46737033
108STK40.46546625
109PIM20.46505324
110STK240.46338618
111CDK90.45272677
112CDK150.44132548
113MET0.42931947
114RPS6KB20.42898495
115DYRK20.42456190
116* CSNK2A10.42255496
117SCYL20.41437766
118MAP3K90.40905324
119CSNK1E0.39960752
120CDK11A0.39548545
121MST1R0.39087043
122PRKDC0.38061938
123YES10.37729914
124MAPK10.37338493
125MOS0.36588785
126BCR0.36501386
127FER0.35654575
128CSNK2A20.35435491
129MAP3K110.35299717
130AKT10.34820304
131ICK0.34397443
132PIM10.33185855

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041103.48086754
2DNA replication_Homo sapiens_hsa030303.47686322
3RNA transport_Homo sapiens_hsa030133.14922917
4Mismatch repair_Homo sapiens_hsa034302.97336157
5Spliceosome_Homo sapiens_hsa030402.90946145
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.64630161
7Basal cell carcinoma_Homo sapiens_hsa052172.21144903
8Base excision repair_Homo sapiens_hsa034102.20813493
9Hippo signaling pathway_Homo sapiens_hsa043902.13824497
10Nucleotide excision repair_Homo sapiens_hsa034202.09521758
11mRNA surveillance pathway_Homo sapiens_hsa030152.09507949
12p53 signaling pathway_Homo sapiens_hsa041152.04438831
13Homologous recombination_Homo sapiens_hsa034401.95067716
14One carbon pool by folate_Homo sapiens_hsa006701.93777117
15Adherens junction_Homo sapiens_hsa045201.92471257
16Hedgehog signaling pathway_Homo sapiens_hsa043401.91482000
17TGF-beta signaling pathway_Homo sapiens_hsa043501.88748952
18* MicroRNAs in cancer_Homo sapiens_hsa052061.83824355
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.81673164
20RNA degradation_Homo sapiens_hsa030181.75887965
21Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.68912428
22Proteoglycans in cancer_Homo sapiens_hsa052051.67753572
23RNA polymerase_Homo sapiens_hsa030201.67182360
24Fanconi anemia pathway_Homo sapiens_hsa034601.55344231
25Steroid biosynthesis_Homo sapiens_hsa001001.49743893
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.48045992
27Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.46005655
28Small cell lung cancer_Homo sapiens_hsa052221.42817062
29Oocyte meiosis_Homo sapiens_hsa041141.41853650
30Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.40216425
31ECM-receptor interaction_Homo sapiens_hsa045121.40215264
32Thyroid cancer_Homo sapiens_hsa052161.39800264
33Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.39528871
34Bladder cancer_Homo sapiens_hsa052191.36989094
35Protein export_Homo sapiens_hsa030601.36697810
36Pyrimidine metabolism_Homo sapiens_hsa002401.35871895
37Ribosome_Homo sapiens_hsa030101.35624333
38Basal transcription factors_Homo sapiens_hsa030221.34377154
39Focal adhesion_Homo sapiens_hsa045101.32491882
40HTLV-I infection_Homo sapiens_hsa051661.31795768
41Proteasome_Homo sapiens_hsa030501.29309756
42Chronic myeloid leukemia_Homo sapiens_hsa052201.27700484
43Wnt signaling pathway_Homo sapiens_hsa043101.20142942
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.15481145
45Prostate cancer_Homo sapiens_hsa052151.12392284
46Colorectal cancer_Homo sapiens_hsa052101.10996093
47Non-homologous end-joining_Homo sapiens_hsa034501.09763703
48Viral myocarditis_Homo sapiens_hsa054161.07386247
49Epstein-Barr virus infection_Homo sapiens_hsa051691.05653285
50Viral carcinogenesis_Homo sapiens_hsa052031.05073070
51Pathways in cancer_Homo sapiens_hsa052001.00849631
52Melanoma_Homo sapiens_hsa052180.99093209
53Shigellosis_Homo sapiens_hsa051310.98668855
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.96167707
55Tight junction_Homo sapiens_hsa045300.95147454
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.91239494
57PI3K-Akt signaling pathway_Homo sapiens_hsa041510.86379644
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.85611910
59* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84814684
60Herpes simplex infection_Homo sapiens_hsa051680.78759354
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78656202
62Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.76685441
63Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.75953892
64Biosynthesis of amino acids_Homo sapiens_hsa012300.75382643
65Regulation of actin cytoskeleton_Homo sapiens_hsa048100.75222943
66Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73210969
67AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70750404
68Notch signaling pathway_Homo sapiens_hsa043300.67866025
69Hepatitis B_Homo sapiens_hsa051610.67439596
70Pancreatic cancer_Homo sapiens_hsa052120.67075980
712-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.66360316
72mTOR signaling pathway_Homo sapiens_hsa041500.66127151
73Glioma_Homo sapiens_hsa052140.65827479
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.64750200
75Pyruvate metabolism_Homo sapiens_hsa006200.63647691
76Endometrial cancer_Homo sapiens_hsa052130.62700128
77HIF-1 signaling pathway_Homo sapiens_hsa040660.62317351
78Purine metabolism_Homo sapiens_hsa002300.61191682
79Dilated cardiomyopathy_Homo sapiens_hsa054140.61090944
80Rap1 signaling pathway_Homo sapiens_hsa040150.60147914
81Non-small cell lung cancer_Homo sapiens_hsa052230.57594064
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56671004
83Melanogenesis_Homo sapiens_hsa049160.53774347
84Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53421602
85Legionellosis_Homo sapiens_hsa051340.51815397
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.50940760
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50142335
88Lysine degradation_Homo sapiens_hsa003100.50109582
89Axon guidance_Homo sapiens_hsa043600.49147914
90Vitamin B6 metabolism_Homo sapiens_hsa007500.47569021
91FoxO signaling pathway_Homo sapiens_hsa040680.47537034
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.45908784
93N-Glycan biosynthesis_Homo sapiens_hsa005100.44864888
94Apoptosis_Homo sapiens_hsa042100.43830460
95Systemic lupus erythematosus_Homo sapiens_hsa053220.43361285
96Antigen processing and presentation_Homo sapiens_hsa046120.43339412
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41567168
98Platelet activation_Homo sapiens_hsa046110.41210699
99Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.40082155
100Renal cell carcinoma_Homo sapiens_hsa052110.40002906
101Thyroid hormone synthesis_Homo sapiens_hsa049180.39007217
102Propanoate metabolism_Homo sapiens_hsa006400.38783707
103Selenocompound metabolism_Homo sapiens_hsa004500.38709552
104Folate biosynthesis_Homo sapiens_hsa007900.34770880
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34138127
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34011728
107Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32531192
108TNF signaling pathway_Homo sapiens_hsa046680.32041000
109Protein digestion and absorption_Homo sapiens_hsa049740.31534661
110Malaria_Homo sapiens_hsa051440.31493930
111Vitamin digestion and absorption_Homo sapiens_hsa049770.31117282
112Fatty acid biosynthesis_Homo sapiens_hsa000610.29914143
113Amoebiasis_Homo sapiens_hsa051460.29559739
114Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.29292412
115ErbB signaling pathway_Homo sapiens_hsa040120.29198105
116Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.28043412
117Glutathione metabolism_Homo sapiens_hsa004800.27843328
118Gap junction_Homo sapiens_hsa045400.26404155
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.25638465
120Salmonella infection_Homo sapiens_hsa051320.25628145
121Complement and coagulation cascades_Homo sapiens_hsa046100.25106263
122Longevity regulating pathway - mammal_Homo sapiens_hsa042110.23713877
123Cysteine and methionine metabolism_Homo sapiens_hsa002700.23224957
124Fat digestion and absorption_Homo sapiens_hsa049750.21453688
125Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.19840911
126Fatty acid metabolism_Homo sapiens_hsa012120.19823251

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