HMGA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a chromatin-associated protein involved in the regulation of gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of AT-rich regions in double-stranded DNA. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been identified on multiple chromosomes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* DNA unwinding involved in DNA replication (GO:0006268)5.32362406
2DNA strand elongation involved in DNA replication (GO:0006271)4.75205924
3protein maturation by protein folding (GO:0022417)4.59548809
4DNA replication initiation (GO:0006270)4.58949494
5DNA strand elongation (GO:0022616)4.49242968
6protein localization to kinetochore (GO:0034501)4.47634051
7folic acid-containing compound biosynthetic process (GO:0009396)4.41525412
8formation of translation preinitiation complex (GO:0001731)4.36732552
9IMP biosynthetic process (GO:0006188)4.27877934
10* establishment of integrated proviral latency (GO:0075713)4.20664667
11telomere maintenance via semi-conservative replication (GO:0032201)4.06466687
12mitotic nuclear envelope disassembly (GO:0007077)4.04574585
13viral transcription (GO:0019083)4.00908852
14maturation of SSU-rRNA (GO:0030490)3.96124931
15translational termination (GO:0006415)3.92499336
16IMP metabolic process (GO:0046040)3.87076198
17membrane disassembly (GO:0030397)3.75990676
18nuclear envelope disassembly (GO:0051081)3.75990676
19nucleobase biosynthetic process (GO:0046112)3.74846188
20ribosomal small subunit assembly (GO:0000028)3.70820090
21protein localization to chromosome, centromeric region (GO:0071459)3.70631600
22translational elongation (GO:0006414)3.68513274
23negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.67901475
24mitotic nuclear envelope reassembly (GO:0007084)3.66430668
25nuclear envelope reassembly (GO:0031468)3.66430668
26DNA replication-dependent nucleosome organization (GO:0034723)3.62621109
27DNA replication-dependent nucleosome assembly (GO:0006335)3.62621109
28translational initiation (GO:0006413)3.61893671
29nuclear pore organization (GO:0006999)3.60180441
30Golgi transport vesicle coating (GO:0048200)3.55913316
31COPI coating of Golgi vesicle (GO:0048205)3.55913316
32regulation of translational fidelity (GO:0006450)3.55116638
33proline biosynthetic process (GO:0006561)3.53583382
34telomere maintenance via recombination (GO:0000722)3.53369066
35pre-miRNA processing (GO:0031054)3.53309599
36nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.51398351
37* establishment of viral latency (GO:0019043)3.49612488
38peptidyl-arginine omega-N-methylation (GO:0035247)3.49420593
39negative regulation of RNA splicing (GO:0033119)3.48351897
40* DNA duplex unwinding (GO:0032508)3.46610932
41mitotic metaphase plate congression (GO:0007080)3.46262079
42* DNA geometric change (GO:0032392)3.44494907
43DNA replication checkpoint (GO:0000076)3.42847325
44regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.41900741
45regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.41321291
46mitotic sister chromatid segregation (GO:0000070)3.41072328
47mitotic recombination (GO:0006312)3.39202765
48nuclear pore complex assembly (GO:0051292)3.35343863
49ribosomal large subunit biogenesis (GO:0042273)3.30205437
50regulation of posttranscriptional gene silencing (GO:0060147)3.29060266
51regulation of gene silencing by miRNA (GO:0060964)3.29060266
52regulation of gene silencing by RNA (GO:0060966)3.29060266
53negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.28508886
54telomere maintenance via telomere lengthening (GO:0010833)3.27478669
55regulation of mammary gland epithelial cell proliferation (GO:0033599)3.24613592
56maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.23824414
57ribosomal small subunit biogenesis (GO:0042274)3.23366960
58L-serine metabolic process (GO:0006563)3.22266099
59DNA deamination (GO:0045006)3.21549845
60protein retention in ER lumen (GO:0006621)3.20528615
61pore complex assembly (GO:0046931)3.20352207
62sister chromatid segregation (GO:0000819)3.19485359
63cellular protein complex localization (GO:0034629)3.19158648
64ribosome assembly (GO:0042255)3.18514439
65* heterochromatin organization (GO:0070828)3.16833948
66regulation of histone H3-K9 methylation (GO:0051570)3.16684315
67nucleotide-excision repair, DNA gap filling (GO:0006297)3.16196050
68ribonucleoprotein complex biogenesis (GO:0022613)3.15523181
69ribosome biogenesis (GO:0042254)3.15063002
70pentose-phosphate shunt (GO:0006098)3.13917928
71cellular protein complex disassembly (GO:0043624)3.13288825
72SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.11350113
73negative regulation of mRNA processing (GO:0050686)3.11045074
74protein complex localization (GO:0031503)3.10464827
75planar cell polarity pathway involved in neural tube closure (GO:0090179)3.10452272
76viral life cycle (GO:0019058)3.10323657
77regulation of translational termination (GO:0006449)3.09090412
78regulation of spindle organization (GO:0090224)3.05963821
79purine nucleobase biosynthetic process (GO:0009113)3.04599158
80metaphase plate congression (GO:0051310)3.04238764
81spliceosomal snRNP assembly (GO:0000387)3.03805220
82mRNA splicing, via spliceosome (GO:0000398)3.03257602
83RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.03257602
84RNA splicing, via transesterification reactions (GO:0000375)3.02378906
85positive regulation of DNA-dependent DNA replication (GO:2000105)3.02289881
86protein targeting to ER (GO:0045047)3.02105564
87histone arginine methylation (GO:0034969)3.01523097
88cotranslational protein targeting to membrane (GO:0006613)3.00675372
89mitotic chromosome condensation (GO:0007076)2.99608905
90nucleobase-containing small molecule interconversion (GO:0015949)2.99489594
91* protein complex disassembly (GO:0043241)2.98935451
92positive regulation of chromosome segregation (GO:0051984)2.98607856
93chromosome condensation (GO:0030261)2.97512988
94regulation of protein heterodimerization activity (GO:0043497)2.96508634
95negative regulation of histone methylation (GO:0031061)2.96313952
96nuclear envelope organization (GO:0006998)2.95657911
973-UTR-mediated mRNA stabilization (GO:0070935)2.95177698
98regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.93390502
99translesion synthesis (GO:0019985)2.92907379
100peptidyl-arginine methylation (GO:0018216)2.92602040
101peptidyl-arginine N-methylation (GO:0035246)2.92602040
102positive regulation of SMAD protein import into nucleus (GO:0060391)2.89281563
103NADPH regeneration (GO:0006740)2.88261477
104rRNA processing (GO:0006364)2.88000143
105negative regulation of mRNA metabolic process (GO:1903312)2.87993611
106establishment of protein localization to endoplasmic reticulum (GO:0072599)2.85445903
107nuclear-transcribed mRNA catabolic process (GO:0000956)2.81769451
108regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.81722652
109establishment of chromosome localization (GO:0051303)2.81077839
110* base-excision repair (GO:0006284)2.80873021
111rRNA metabolic process (GO:0016072)2.78091376
112DNA topological change (GO:0006265)2.78042765
113* macromolecular complex disassembly (GO:0032984)2.77904851
114termination of RNA polymerase II transcription (GO:0006369)2.76965815
115RNA catabolic process (GO:0006401)2.75958168
116protein localization to endoplasmic reticulum (GO:0070972)2.75719637
117* DNA conformation change (GO:0071103)2.74813070
118protein localization to chromosome (GO:0034502)2.74371305
119glucose catabolic process (GO:0006007)2.74175110
120mitotic G1 DNA damage checkpoint (GO:0031571)2.73612693
121convergent extension (GO:0060026)2.71497555
122dosage compensation (GO:0007549)2.69514654
123paraxial mesoderm development (GO:0048339)2.68722826
124mRNA catabolic process (GO:0006402)2.68390494
125postreplication repair (GO:0006301)2.68266656
126regulation of mitotic spindle organization (GO:0060236)2.67725442
127kinetochore organization (GO:0051383)2.66209222
128mRNA stabilization (GO:0048255)2.65601492
129RNA stabilization (GO:0043489)2.65601492
130protein export from nucleus (GO:0006611)2.65243241
131spliceosomal tri-snRNP complex assembly (GO:0000244)2.64083486
132regulation of translational elongation (GO:0006448)2.62446787
133regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.61194540
134* protein-DNA complex disassembly (GO:0032986)2.58679352
135* nucleosome disassembly (GO:0006337)2.58679352
136rRNA transcription (GO:0009303)2.56990434
137regulation of chromosome segregation (GO:0051983)2.55991486
138regulation of cell fate specification (GO:0042659)2.55680391
139mitotic sister chromatid cohesion (GO:0007064)2.53782579
140DNA packaging (GO:0006323)2.53266739
141negative regulation of cell fate specification (GO:0009996)2.51800114
142transcription-coupled nucleotide-excision repair (GO:0006283)2.51001263
143ATP-dependent chromatin remodeling (GO:0043044)2.46907760

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.42232947
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.19704926
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.11220659
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.92265964
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.27766689
6* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.98916914
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.94473889
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.86362065
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.62028700
10* MYC_22102868_ChIP-Seq_BL_Human2.60163689
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.53045921
12* XRN2_22483619_ChIP-Seq_HELA_Human2.27642049
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.21582601
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.14321832
15* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.11095028
16AR_21909140_ChIP-Seq_LNCAP_Human1.99260297
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.94167550
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.91948775
19ZNF263_19887448_ChIP-Seq_K562_Human1.90977723
20* E2F1_21310950_ChIP-Seq_MCF-7_Human1.90250186
21CREB1_15753290_ChIP-ChIP_HEK293T_Human1.88969126
22VDR_21846776_ChIP-Seq_THP-1_Human1.85623382
23KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.85581215
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.80106942
25GABP_17652178_ChIP-ChIP_JURKAT_Human1.79181851
26CIITA_25753668_ChIP-Seq_RAJI_Human1.77549777
27MYCN_18555785_ChIP-Seq_MESCs_Mouse1.70569576
28E2F1_18555785_ChIP-Seq_MESCs_Mouse1.68552036
29TTF2_22483619_ChIP-Seq_HELA_Human1.68546168
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.66667696
31POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.66539023
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.66162296
33* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.62554928
34NANOG_18555785_ChIP-Seq_MESCs_Mouse1.59048585
35* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.58850619
36* VDR_23849224_ChIP-Seq_CD4+_Human1.58212302
37DCP1A_22483619_ChIP-Seq_HELA_Human1.57316435
38NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.57094077
39GABP_19822575_ChIP-Seq_HepG2_Human1.55759024
40FOXP3_21729870_ChIP-Seq_TREG_Human1.55342503
41CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.53869150
42ELF1_17652178_ChIP-ChIP_JURKAT_Human1.52528964
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.52357135
44ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50953029
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.50507566
46* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.46447658
47TP63_19390658_ChIP-ChIP_HaCaT_Human1.45579642
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.44873668
49KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.40431523
50TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39573526
51ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.38991368
52KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.38718434
53KDM5A_27292631_Chip-Seq_BREAST_Human1.38187935
54SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.35183182
55CLOCK_20551151_ChIP-Seq_293T_Human1.34729689
56* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.31586445
57SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.31391639
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30711521
59* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.30367397
60RACK7_27058665_Chip-Seq_MCF-7_Human1.30147832
61TFEB_21752829_ChIP-Seq_HELA_Human1.29179653
62STAT3_1855785_ChIP-Seq_MESCs_Mouse1.28936855
63KLF4_18555785_ChIP-Seq_MESCs_Mouse1.28165559
64TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.26584173
65TP63_17297297_ChIP-ChIP_HaCaT_Human1.25696459
66DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.24473375
67LXR_22292898_ChIP-Seq_THP-1_Human1.23676475
68YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23598940
69* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.22518504
70KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21583740
71SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20901737
72PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.17026721
73CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.16336773
74* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.14940383
75ELK3_25401928_ChIP-Seq_HUVEC_Human1.14538482
76RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.14420045
77TCF3_18692474_ChIP-Seq_MEFs_Mouse1.12808443
78E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11682335
79ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.11553941
80YY1_21170310_ChIP-Seq_MESCs_Mouse1.10743899
81KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09827133
82SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.09056814
83ELK1_19687146_ChIP-ChIP_HELA_Human1.07888515
84* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.07714981
85* NCOR1_26117541_ChIP-Seq_K562_Human1.07590869
86TET1_21451524_ChIP-Seq_MESCs_Mouse1.07172479
87SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.06836091
88SOX2_18555785_ChIP-Seq_MESCs_Mouse1.06086333
89HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04315642
90FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01738116
91UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.01547498
92POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01403077
93HIF1A_21447827_ChIP-Seq_MCF-7_Human1.01173388
94SOX2_18692474_ChIP-Seq_MEFs_Mouse1.01033115
95* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00782585
96* TCF7_22412390_ChIP-Seq_EML_Mouse1.00745445
97TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.00534404
98SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.00382981
99* UTX_26944678_Chip-Seq_JUKART_Human0.99531495
100ERG_20887958_ChIP-Seq_HPC-7_Mouse0.97683363
101* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97533120
102PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.96664034
103FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.96146645
104MAF_26560356_Chip-Seq_TH1_Human0.96134023
105HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.96073282
106TBX5_21415370_ChIP-Seq_HL-1_Mouse0.95440701
107CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95340281
108SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.95303297
109SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.95011153
110NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.94661320
111SPI1_23547873_ChIP-Seq_NB4_Human0.94477417
112* TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.93939825
113ATF3_27146783_Chip-Seq_COLON_Human0.92301853
114* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.91978820
115NANOG_21062744_ChIP-ChIP_HESCs_Human0.91379859
116HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.91166847
117* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90655634
118OCT4_18692474_ChIP-Seq_MEFs_Mouse0.90258053
119* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.87758037
120ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.86666612
121NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.86645324
122* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86613098
123KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.85725597
124KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.85725597
125KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.85725597

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.15108596
2MP0003111_abnormal_nucleus_morphology3.81072939
3MP0004957_abnormal_blastocyst_morpholog3.74272888
4MP0010094_abnormal_chromosome_stability3.68945907
5MP0003077_abnormal_cell_cycle3.44939300
6MP0010352_gastrointestinal_tract_polyps3.23710399
7MP0008057_abnormal_DNA_replication2.83511682
8MP0002877_abnormal_melanocyte_morpholog2.72046503
9MP0001730_embryonic_growth_arrest2.51630366
10MP0008007_abnormal_cellular_replicative2.50967699
11MP0010030_abnormal_orbit_morphology2.49280150
12MP0003123_paternal_imprinting2.34604997
13MP0000350_abnormal_cell_proliferation2.31733121
14MP0002254_reproductive_system_inflammat2.28068730
15MP0008932_abnormal_embryonic_tissue2.24997768
16MP0005257_abnormal_intraocular_pressure2.20497046
17MP0008058_abnormal_DNA_repair2.20121964
18MP0010307_abnormal_tumor_latency2.17970609
19MP0002396_abnormal_hematopoietic_system2.17288360
20MP0004272_abnormal_basement_membrane2.09191213
21MP0003705_abnormal_hypodermis_morpholog2.09023872
22MP0005076_abnormal_cell_differentiation2.02957735
23MP0004808_abnormal_hematopoietic_stem1.89419524
24MP0004185_abnormal_adipocyte_glucose1.88906553
25MP0001697_abnormal_embryo_size1.81981348
26MP0001672_abnormal_embryogenesis/_devel1.81311483
27MP0005380_embryogenesis_phenotype1.81311483
28MP0009278_abnormal_bone_marrow1.72632291
29MP0002085_abnormal_embryonic_tissue1.70719462
30MP0004197_abnormal_fetal_growth/weight/1.69959364
31MP0000490_abnormal_crypts_of1.69598846
32MP0003984_embryonic_growth_retardation1.69417027
33MP0000537_abnormal_urethra_morphology1.69092377
34MP0002796_impaired_skin_barrier1.67810178
35MP0002088_abnormal_embryonic_growth/wei1.66499294
36MP0002080_prenatal_lethality1.65493619
37MP0002084_abnormal_developmental_patter1.65091910
38MP0009053_abnormal_anal_canal1.62354190
39MP0008877_abnormal_DNA_methylation1.55893631
40MP0009697_abnormal_copulation1.51996412
41MP0005451_abnormal_body_composition1.51375569
42MP0002086_abnormal_extraembryonic_tissu1.50629490
43MP0004858_abnormal_nervous_system1.48536753
44MP0010234_abnormal_vibrissa_follicle1.48097162
45MP0003890_abnormal_embryonic-extraembry1.43574323
46MP0000313_abnormal_cell_death1.41276532
47MP0003566_abnormal_cell_adhesion1.38429002
48* MP0002019_abnormal_tumor_incidence1.36967038
49MP0001545_abnormal_hematopoietic_system1.33354010
50MP0005397_hematopoietic_system_phenotyp1.33354010
51MP0003119_abnormal_digestive_system1.32634053
52MP0003718_maternal_effect1.31418661
53MP0005023_abnormal_wound_healing1.31208428
54MP0009333_abnormal_splenocyte_physiolog1.29236689
55MP0001293_anophthalmia1.29096867
56MP0000751_myopathy1.28014289
57MP0001299_abnormal_eye_distance/1.27384042
58MP0001849_ear_inflammation1.23749168
59MP0009672_abnormal_birth_weight1.22644333
60MP0002653_abnormal_ependyma_morphology1.22561157
61MP0003121_genomic_imprinting1.20257264
62MP0000703_abnormal_thymus_morphology1.19846175
63MP0000858_altered_metastatic_potential1.16396582
64MP0003567_abnormal_fetal_cardiomyocyte1.12486810
65MP0004133_heterotaxia1.10267269
66MP0002111_abnormal_tail_morphology1.09660123
67MP0000733_abnormal_muscle_development1.07141966
68MP0000566_synostosis1.06265692
69MP0003303_peritoneal_inflammation1.06097465
70MP0002398_abnormal_bone_marrow1.05883670
71MP0001915_intracranial_hemorrhage1.05553076
72MP0000762_abnormal_tongue_morphology1.03757083
73MP0003283_abnormal_digestive_organ1.02632596
74* MP0002722_abnormal_immune_system1.02098613
75MP0000678_abnormal_parathyroid_gland1.01937696
76MP0003786_premature_aging1.01641775
77MP0006054_spinal_hemorrhage1.01537479
78MP0004233_abnormal_muscle_weight1.01031198
79MP0003950_abnormal_plasma_membrane1.00413728
80MP0003385_abnormal_body_wall0.99825659
81MP0002060_abnormal_skin_morphology0.99011455
82MP0005623_abnormal_meninges_morphology0.96614058
83MP0003942_abnormal_urinary_system0.95514695
84MP0000428_abnormal_craniofacial_morphol0.94742924
85MP0002089_abnormal_postnatal_growth/wei0.91332304
86MP0009703_decreased_birth_body0.90944477
87MP0003315_abnormal_perineum_morphology0.89619080
88* MP0000689_abnormal_spleen_morphology0.88702681
89MP0000003_abnormal_adipose_tissue0.87990754
90MP0004264_abnormal_extraembryonic_tissu0.87007240
91MP0002925_abnormal_cardiovascular_devel0.82618926
92MP0005621_abnormal_cell_physiology0.81798578
93MP0008260_abnormal_autophagy0.81311633
94MP0005384_cellular_phenotype0.79966536
95MP0001216_abnormal_epidermal_layer0.79885819
96* MP0002429_abnormal_blood_cell0.79734636
97MP0000358_abnormal_cell_content/0.79329883
98MP0003221_abnormal_cardiomyocyte_apopto0.78551170
99MP0010630_abnormal_cardiac_muscle0.77346608
100MP0003436_decreased_susceptibility_to0.77176479
101MP0000477_abnormal_intestine_morphology0.76992206
102MP0002092_abnormal_eye_morphology0.75789887
103MP0005501_abnormal_skin_physiology0.75767181
104MP0008770_decreased_survivor_rate0.75396356
105MP0003763_abnormal_thymus_physiology0.75343129
106MP0003448_altered_tumor_morphology0.75199722
107MP0002697_abnormal_eye_size0.74632903
108MP0005666_abnormal_adipose_tissue0.74499876
109MP0003937_abnormal_limbs/digits/tail_de0.74274010
110MP0001661_extended_life_span0.73786673
111MP0000432_abnormal_head_morphology0.73704085
112MP0005197_abnormal_uvea_morphology0.73532867
113MP0000534_abnormal_ureter_morphology0.73259600
114MP0003091_abnormal_cell_migration0.72582126
115MP0006292_abnormal_olfactory_placode0.72437052
116MP0001340_abnormal_eyelid_morphology0.72259600
117MP0003115_abnormal_respiratory_system0.70289595
118MP0003941_abnormal_skin_development0.68215240
119MP0008789_abnormal_olfactory_epithelium0.68202078
120MP0000750_abnormal_muscle_regeneration0.67359918
121MP0002932_abnormal_joint_morphology0.66869233
122* MP0000716_abnormal_immune_system0.66505676
123MP0000685_abnormal_immune_system0.66246061
124MP0001286_abnormal_eye_development0.65626707
125MP0002282_abnormal_trachea_morphology0.65128719
126MP0002405_respiratory_system_inflammati0.62718069
127MP0000049_abnormal_middle_ear0.60948379
128MP0003935_abnormal_craniofacial_develop0.60460171
129MP0001853_heart_inflammation0.57998765
130* MP0000266_abnormal_heart_morphology0.57731094
131MP0002452_abnormal_antigen_presenting0.55574156
132MP0003861_abnormal_nervous_system0.55274716
133MP0003453_abnormal_keratinocyte_physiol0.53648463
134* MP0001145_abnormal_male_reproductive0.53117952

Predicted human phenotypes

RankGene SetZ-score
1Selective tooth agenesis (HP:0001592)3.69121269
2Reticulocytopenia (HP:0001896)3.61126974
3Colon cancer (HP:0003003)3.56610746
4Premature rupture of membranes (HP:0001788)3.28112983
5Insomnia (HP:0100785)3.18862157
6Abnormality of cells of the erythroid lineage (HP:0012130)3.12799195
7Oral leukoplakia (HP:0002745)3.04994173
8Birth length less than 3rd percentile (HP:0003561)3.04839714
9Ependymoma (HP:0002888)3.01814226
10Medulloblastoma (HP:0002885)3.01689649
11Degeneration of anterior horn cells (HP:0002398)2.98286105
12Abnormality of the anterior horn cell (HP:0006802)2.98286105
13Distal lower limb amyotrophy (HP:0008944)2.92759874
14Abnormal number of incisors (HP:0011064)2.91932235
15Achilles tendon contracture (HP:0001771)2.88820950
16Upper limb muscle weakness (HP:0003484)2.86343718
17Abnormal number of erythroid precursors (HP:0012131)2.84230332
18Trismus (HP:0000211)2.79458658
19Patellar aplasia (HP:0006443)2.73220702
20Progressive muscle weakness (HP:0003323)2.72606508
21Cholecystitis (HP:0001082)2.71383927
22Abnormal gallbladder physiology (HP:0012438)2.71383927
23Agnosia (HP:0010524)2.69890284
24Long palpebral fissure (HP:0000637)2.64535045
25Aplasia/Hypoplasia of the patella (HP:0006498)2.58350930
26Breast hypoplasia (HP:0003187)2.55871359
27Deviation of the thumb (HP:0009603)2.54012245
28Increased nuchal translucency (HP:0010880)2.52348122
29Overriding aorta (HP:0002623)2.52143501
30Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.52142279
31Short 4th metacarpal (HP:0010044)2.52142279
32Proximal placement of thumb (HP:0009623)2.50952704
33Aplastic anemia (HP:0001915)2.50931309
34Basal cell carcinoma (HP:0002671)2.50808581
35Absent thumb (HP:0009777)2.49577511
36Spastic diplegia (HP:0001264)2.48956521
37Shoulder girdle muscle weakness (HP:0003547)2.45311988
38Increased connective tissue (HP:0009025)2.44872153
39Abnormality of the Achilles tendon (HP:0005109)2.42752381
40Lower limb amyotrophy (HP:0007210)2.42722767
41Upper limb amyotrophy (HP:0009129)2.41751494
42Distal upper limb amyotrophy (HP:0007149)2.41751494
43Increased density of long bones (HP:0006392)2.36760924
44High anterior hairline (HP:0009890)2.35732731
45Entropion (HP:0000621)2.34646509
46Pelvic girdle muscle weakness (HP:0003749)2.33722791
47Rough bone trabeculation (HP:0100670)2.32639903
48Hyperacusis (HP:0010780)2.32313792
49Atresia of the external auditory canal (HP:0000413)2.31664529
50Renal duplication (HP:0000075)2.30467208
51Cortical dysplasia (HP:0002539)2.30299365
52Neoplasm of the pancreas (HP:0002894)2.29983566
53Missing ribs (HP:0000921)2.29630722
54Rhabdomyosarcoma (HP:0002859)2.29347752
55Spinal rigidity (HP:0003306)2.28259748
56Centrally nucleated skeletal muscle fibers (HP:0003687)2.28243141
57Disproportionate tall stature (HP:0001519)2.28000278
58Carpal bone hypoplasia (HP:0001498)2.25988039
59Difficulty climbing stairs (HP:0003551)2.23528929
60Pallor (HP:0000980)2.20968370
61Aplasia/Hypoplasia of the sacrum (HP:0008517)2.19582281
62Skin tags (HP:0010609)2.19199959
63Preauricular skin tag (HP:0000384)2.17371423
64High pitched voice (HP:0001620)2.17261915
65Arnold-Chiari malformation (HP:0002308)2.16635539
66Short nail (HP:0001799)2.14558470
67Abnormality of the calcaneus (HP:0008364)2.13156372
68Tracheoesophageal fistula (HP:0002575)2.13020119
69Vertebral compression fractures (HP:0002953)2.12497440
70Shallow orbits (HP:0000586)2.12023790
71Natal tooth (HP:0000695)2.10600017
72Absent radius (HP:0003974)2.10502280
73Distal lower limb muscle weakness (HP:0009053)2.08686100
74Thrombocytosis (HP:0001894)2.08513503
75Cellular immunodeficiency (HP:0005374)2.07530278
76Macrocytic anemia (HP:0001972)2.07020201
77Ectopic kidney (HP:0000086)2.06617644
78Multiple enchondromatosis (HP:0005701)2.06461064
79Chromsome breakage (HP:0040012)2.05832182
80Abnormality of abdominal situs (HP:0011620)2.05285870
81Abdominal situs inversus (HP:0003363)2.05285870
82Abnormality of the astrocytes (HP:0100707)2.02757484
83Astrocytoma (HP:0009592)2.02757484
84Neoplasm of striated muscle (HP:0009728)2.02305321
8511 pairs of ribs (HP:0000878)2.02224657
86Elfin facies (HP:0004428)2.02057245
87Squamous cell carcinoma (HP:0002860)2.01165194
88Angiofibromas (HP:0010615)2.01153738
89Adenoma sebaceum (HP:0009720)2.01153738
90Overlapping toe (HP:0001845)2.00961936
91Hand muscle atrophy (HP:0009130)2.00619865
92Premature graying of hair (HP:0002216)2.00043511
93Rib fusion (HP:0000902)1.99894609
94Osteolytic defects of the phalanges of the hand (HP:0009771)1.99120364
95Osteolytic defects of the hand bones (HP:0009699)1.99120364
96Ankyloglossia (HP:0010296)1.98733580
97Long eyelashes (HP:0000527)1.98550560
98Myelodysplasia (HP:0002863)1.98500519
99Reduced subcutaneous adipose tissue (HP:0003758)1.95745866
100Abnormality of the umbilical cord (HP:0010881)1.94856343
101Poikiloderma (HP:0001029)1.93761798
102Absent forearm bone (HP:0003953)1.93470204
103Aplasia involving forearm bones (HP:0009822)1.93470204
104Cutaneous melanoma (HP:0012056)1.92893935
105Ulnar bowing (HP:0003031)1.91117410
106Microretrognathia (HP:0000308)1.90966918
107Abnormality of reticulocytes (HP:0004312)1.90512550
108Abnormality of the musculature of the pelvis (HP:0001469)1.89941669
109Abnormality of the hip-girdle musculature (HP:0001445)1.89941669
110Abnormality of oral frenula (HP:0000190)1.89568728
111Urethral obstruction (HP:0000796)1.88707606
112Glossoptosis (HP:0000162)1.87042702
113Chromosomal breakage induced by crosslinking agents (HP:0003221)1.86713324
114Atrophy/Degeneration involving motor neurons (HP:0007373)1.86310801
115Asplenia (HP:0001746)1.86059142
116Orthostatic hypotension (HP:0001278)1.85877740
117Syringomyelia (HP:0003396)1.83677599
118Spinal cord lesions (HP:0100561)1.83677599
119Pointed chin (HP:0000307)1.83382588
120Protrusio acetabuli (HP:0003179)1.83303148
121Esophageal atresia (HP:0002032)1.82916519
122Generalized amyotrophy (HP:0003700)1.82834909
123Midface retrusion (HP:0011800)1.82816479
124Neoplasm of the oral cavity (HP:0100649)1.82717517
125Meckel diverticulum (HP:0002245)1.82356130
126Aplasia involving bones of the extremities (HP:0009825)1.80364923
127Aplasia involving bones of the upper limbs (HP:0009823)1.80364923
128Aplasia of the phalanges of the hand (HP:0009802)1.80364923
129Facial cleft (HP:0002006)1.79878430
130Abnormal lung lobation (HP:0002101)1.79852923
131Progressive hearing impairment (HP:0001730)1.79554555
132Aplasia/Hypoplasia of the spleen (HP:0010451)1.79236703
133Malignant gastrointestinal tract tumors (HP:0006749)1.78847285
134Gastrointestinal carcinoma (HP:0002672)1.78847285
135Rectal prolapse (HP:0002035)1.78487119
136Slender long bone (HP:0003100)1.78217956
137Aplasia/Hypoplasia of the breasts (HP:0010311)1.77484170
138Microglossia (HP:0000171)1.77279056
139Acute lymphatic leukemia (HP:0006721)1.75573234
140Abnormality of the ileum (HP:0001549)1.75332463
141Abnormality of the distal phalanges of the toes (HP:0010182)1.75224845
142Amaurosis fugax (HP:0100576)1.73696955
143Abnormality of subcutaneous fat tissue (HP:0001001)1.73624720
144Progressive external ophthalmoplegia (HP:0000590)1.73503457
145Abnormality of chromosome stability (HP:0003220)1.73325905
146Duplication of thumb phalanx (HP:0009942)1.72533329
147Supernumerary spleens (HP:0009799)1.71210415
148Trigonocephaly (HP:0000243)1.70648941
149Abnormality of the 4th metacarpal (HP:0010012)1.70430502
150Cleft eyelid (HP:0000625)1.69674214
151Aplasia/hypoplasia of the humerus (HP:0006507)1.69341880
152Bone marrow hypocellularity (HP:0005528)1.69058035
153Cellulitis (HP:0100658)1.68429931
154Genu recurvatum (HP:0002816)1.68424947
155Horseshoe kidney (HP:0000085)1.67391005
156Small intestinal stenosis (HP:0012848)1.67369520
157Duodenal stenosis (HP:0100867)1.67369520
158Limb-girdle muscle atrophy (HP:0003797)1.66754131
159Abnormality of the preputium (HP:0100587)1.65854705
160Aplasia/Hypoplasia of the uvula (HP:0010293)1.65634681
161Spinal muscular atrophy (HP:0007269)1.65581849
162Cafe-au-lait spot (HP:0000957)1.65038803
163Bronchomalacia (HP:0002780)1.64518834
164Ankle contracture (HP:0006466)1.63434006
165Skull defect (HP:0001362)1.63139734
166Reticulocytosis (HP:0001923)1.63038667
167Broad distal phalanx of finger (HP:0009836)1.62566705
168Abnormal trabecular bone morphology (HP:0100671)1.62324537
169Choanal stenosis (HP:0000452)1.62266083
170Secondary amenorrhea (HP:0000869)1.61686088
171Breast aplasia (HP:0100783)1.60029346
172Patellar dislocation (HP:0002999)1.59698887
173Broad face (HP:0000283)1.59680469
174Delayed cranial suture closure (HP:0000270)1.58655310
175Breech presentation (HP:0001623)1.58234572
176Myocardial infarction (HP:0001658)1.58161171
177Back pain (HP:0003418)1.56734157
178Nephroblastoma (Wilms tumor) (HP:0002667)1.56530893
179Pseudobulbar signs (HP:0002200)1.56389195

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.92577168
2VRK23.56218381
3BUB13.48863637
4MAP3K103.42660005
5EEF2K3.38683119
6SMG13.31971185
7WEE12.99876895
8PKN22.77765760
9IRAK32.56559635
10NEK22.55695767
11TESK22.41778076
12CDK122.40986738
13TRIB32.07764178
14TSSK62.03980681
15STK101.94917201
16PASK1.94666194
17RPS6KA41.93164253
18NEK11.83290391
19MST1R1.79422293
20TTK1.79079336
21CDK71.75115059
22PAK41.72478726
23MAP3K81.70703470
24RPS6KB21.65055247
25ERBB41.61611305
26SCYL21.59801843
27ARAF1.54166876
28EIF2AK11.53444768
29MKNK11.53258717
30CDK41.50273475
31TAF11.50158412
32EPHA21.49219366
33LMTK21.48168922
34PLK11.47389012
35ATR1.45107744
36LRRK21.44931898
37NME21.40770627
38TGFBR11.39970478
39TESK11.39862933
40MET1.36605590
41AURKB1.36190697
42PRPF4B1.28508846
43SIK11.25152350
44MAP3K111.24996088
45ERN11.24427135
46SRPK11.23799173
47MAP4K11.23581261
48FLT31.16912768
49DYRK31.11886555
50MAP2K31.11652726
51CHEK11.11082606
52BRAF1.10229333
53BRSK21.10052533
54PIM21.09771724
55PBK1.07542066
56ALK1.07133345
57STK41.06750457
58AURKA1.03328374
59CDK61.02365580
60BRD41.01993320
61GRK61.01195118
62DAPK10.99352210
63LATS20.95777849
64BMX0.92375254
65CHEK20.92296801
66NTRK10.90264410
67ACVR1B0.89031814
68PLK40.88559595
69KDR0.88515769
70TLK10.85773321
71PLK30.84834020
72PTK60.84056720
73MTOR0.83023474
74* CDK20.82888113
75MOS0.82219796
76PAK10.81189745
77PIM10.80189094
78MAP3K90.79590734
79BTK0.79104032
80DMPK0.78223176
81TTN0.75436276
82BRSK10.75285487
83CDK190.75095295
84MKNK20.74314458
85PAK20.73966663
86EIF2AK30.72804005
87ICK0.72391017
88* ATM0.67012536
89AKT20.65403687
90FGFR10.63661450
91EPHB10.63141687
92VRK10.59719132
93PRKG20.58869948
94LIMK10.57378812
95STK30.55578248
96CDK11A0.54680619
97EIF2AK20.54142354
98* CSNK2A20.53572028
99CLK10.52994946
100ILK0.52516558
101EPHB20.51329099
102MAP3K30.50497500
103CDK150.50220975
104* CDK10.49499191
105CDK180.48463371
106* CSNK2A10.47639615
107CDK140.47594662
108MST40.47444490
109CDK80.47431680
110CDK90.44909115
111PDGFRA0.44707344
112MAP2K20.43866291
113FGFR40.43448301
114ABL20.42443366
115TAOK20.42218653
116MAPKAPK30.41833099
117ZAP700.41814372
118MELK0.41534731
119MAPKAPK20.41276835
120BLK0.41162766
121TAOK10.40225437
122CAMK1D0.39079762
123CSNK1E0.39073956
124DYRK1B0.37559022
125STK160.36123485
126LATS10.36077674
127RPS6KA10.33554076
128RIPK10.27803589
129CSF1R0.27663753
130AKT10.26983120
131CHUK0.26912491
132PTK20.26665368
133PRKCI0.26034798

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.86887979
2Mismatch repair_Homo sapiens_hsa034303.92884286
3Spliceosome_Homo sapiens_hsa030403.35937480
4Ribosome_Homo sapiens_hsa030103.10588679
5Base excision repair_Homo sapiens_hsa034103.06815610
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.04128033
7RNA transport_Homo sapiens_hsa030133.00351420
8One carbon pool by folate_Homo sapiens_hsa006702.88720313
9Cell cycle_Homo sapiens_hsa041102.66845984
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.50761615
11Nucleotide excision repair_Homo sapiens_hsa034202.39916839
12Homologous recombination_Homo sapiens_hsa034402.36569553
13RNA polymerase_Homo sapiens_hsa030202.19348115
14Proteasome_Homo sapiens_hsa030502.12873464
15Pyrimidine metabolism_Homo sapiens_hsa002401.94078422
16mRNA surveillance pathway_Homo sapiens_hsa030151.86914312
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.81782161
18p53 signaling pathway_Homo sapiens_hsa041151.72281033
19Non-homologous end-joining_Homo sapiens_hsa034501.72118926
20RNA degradation_Homo sapiens_hsa030181.67331971
21Fanconi anemia pathway_Homo sapiens_hsa034601.49879239
22Epstein-Barr virus infection_Homo sapiens_hsa051691.23046192
23Folate biosynthesis_Homo sapiens_hsa007901.23006807
24Fructose and mannose metabolism_Homo sapiens_hsa000511.21490722
25Viral carcinogenesis_Homo sapiens_hsa052031.18112060
26Thyroid cancer_Homo sapiens_hsa052161.17616522
27MicroRNAs in cancer_Homo sapiens_hsa052061.13813434
28Chronic myeloid leukemia_Homo sapiens_hsa052201.12555321
29Biosynthesis of amino acids_Homo sapiens_hsa012301.11346833
30HTLV-I infection_Homo sapiens_hsa051661.09671624
31Antigen processing and presentation_Homo sapiens_hsa046121.05934685
32Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.05840704
33Basal transcription factors_Homo sapiens_hsa030221.02994856
34Herpes simplex infection_Homo sapiens_hsa051681.01398749
35Small cell lung cancer_Homo sapiens_hsa052220.99321939
36Bladder cancer_Homo sapiens_hsa052190.98208194
37Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.93587180
38Basal cell carcinoma_Homo sapiens_hsa052170.93322259
39Pyruvate metabolism_Homo sapiens_hsa006200.93148876
40Shigellosis_Homo sapiens_hsa051310.89840215
41Pentose phosphate pathway_Homo sapiens_hsa000300.89053063
42Central carbon metabolism in cancer_Homo sapiens_hsa052300.88692312
43Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.87972404
44Legionellosis_Homo sapiens_hsa051340.87513185
45Cysteine and methionine metabolism_Homo sapiens_hsa002700.86246875
46Apoptosis_Homo sapiens_hsa042100.85987630
47Systemic lupus erythematosus_Homo sapiens_hsa053220.85548208
48Notch signaling pathway_Homo sapiens_hsa043300.84752878
49Colorectal cancer_Homo sapiens_hsa052100.82707600
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.82152057
51Oocyte meiosis_Homo sapiens_hsa041140.80155309
52Hippo signaling pathway_Homo sapiens_hsa043900.79807665
53Acute myeloid leukemia_Homo sapiens_hsa052210.79423593
54Purine metabolism_Homo sapiens_hsa002300.79221506
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78653737
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.78453717
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77295614
58Vitamin B6 metabolism_Homo sapiens_hsa007500.75597671
59HIF-1 signaling pathway_Homo sapiens_hsa040660.75435276
60Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.73416368
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.70686095
62Focal adhesion_Homo sapiens_hsa045100.70474162
63Fatty acid elongation_Homo sapiens_hsa000620.69884671
64Selenocompound metabolism_Homo sapiens_hsa004500.68091082
65Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.66913575
66Hepatitis B_Homo sapiens_hsa051610.65951396
67TGF-beta signaling pathway_Homo sapiens_hsa043500.65067216
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64936015
69Non-small cell lung cancer_Homo sapiens_hsa052230.64355087
70Viral myocarditis_Homo sapiens_hsa054160.63417924
71Tight junction_Homo sapiens_hsa045300.61772148
72Regulation of actin cytoskeleton_Homo sapiens_hsa048100.61619459
73Leishmaniasis_Homo sapiens_hsa051400.61196764
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61061821
75Proteoglycans in cancer_Homo sapiens_hsa052050.60831514
76Adherens junction_Homo sapiens_hsa045200.59777632
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59694720
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.57880861
79Sulfur relay system_Homo sapiens_hsa041220.56760039
80Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.56573203
81Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.56324292
82Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56103209
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54152413
84Measles_Homo sapiens_hsa051620.52169818
85Pathways in cancer_Homo sapiens_hsa052000.51502071
86Insulin signaling pathway_Homo sapiens_hsa049100.50695757
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50015625
88Hedgehog signaling pathway_Homo sapiens_hsa043400.49806237
89Leukocyte transendothelial migration_Homo sapiens_hsa046700.49747242
90Pancreatic cancer_Homo sapiens_hsa052120.49003161
91mTOR signaling pathway_Homo sapiens_hsa041500.48714775
92Carbon metabolism_Homo sapiens_hsa012000.48662815
93Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48616672
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.48557914
95ErbB signaling pathway_Homo sapiens_hsa040120.48122554
96B cell receptor signaling pathway_Homo sapiens_hsa046620.46726075
97Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.45932707
98Prion diseases_Homo sapiens_hsa050200.45672071
99Renal cell carcinoma_Homo sapiens_hsa052110.44117564
100Vibrio cholerae infection_Homo sapiens_hsa051100.42440357
101Prostate cancer_Homo sapiens_hsa052150.42313315
102Melanoma_Homo sapiens_hsa052180.42308535
103Influenza A_Homo sapiens_hsa051640.42057863
104NF-kappa B signaling pathway_Homo sapiens_hsa040640.41965603
105Drug metabolism - other enzymes_Homo sapiens_hsa009830.41666925
106Endometrial cancer_Homo sapiens_hsa052130.41436332
107Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39418132
108Salmonella infection_Homo sapiens_hsa051320.38585597
109Primary immunodeficiency_Homo sapiens_hsa053400.38074476
110Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37786616
111AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.37302750
112AMPK signaling pathway_Homo sapiens_hsa041520.36168038
113N-Glycan biosynthesis_Homo sapiens_hsa005100.36083248
114VEGF signaling pathway_Homo sapiens_hsa043700.34282739
115NOD-like receptor signaling pathway_Homo sapiens_hsa046210.33649895
116Toxoplasmosis_Homo sapiens_hsa051450.31655417
117Galactose metabolism_Homo sapiens_hsa000520.31401690
118Lysine degradation_Homo sapiens_hsa003100.30162976
119Glutathione metabolism_Homo sapiens_hsa004800.27661148
1202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.26869836
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26682043
122Glioma_Homo sapiens_hsa052140.26465874
123PI3K-Akt signaling pathway_Homo sapiens_hsa041510.26432009
124Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.26213267
125Wnt signaling pathway_Homo sapiens_hsa043100.26027732

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »