HMCN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a large extracellular member of the immunoglobulin superfamily. A similar protein in C. elegans forms long, fine tracks at specific extracellular sites that are involved in many processes such as stabilization of the germline syncytium, anchorage of mechanosensory neurons to the epidermis, and organization of hemidesmosomes in the epidermis. Mutations in this gene may be associated with age-related macular degeneration. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sequestering of extracellular ligand from receptor (GO:0035581)5.94219475
2branching involved in salivary gland morphogenesis (GO:0060445)5.89438391
3melanin biosynthetic process (GO:0042438)5.23225221
4collagen fibril organization (GO:0030199)4.88359093
5lateral sprouting from an epithelium (GO:0060601)4.84970543
6melanin metabolic process (GO:0006582)4.73394009
7bone trabecula formation (GO:0060346)4.71415690
8cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.69555215
9lymph vessel development (GO:0001945)4.56603928
10basement membrane organization (GO:0071711)4.40194175
11cell proliferation involved in metanephros development (GO:0072203)4.38637879
12mesenchymal-epithelial cell signaling (GO:0060638)4.33644223
13secondary metabolite biosynthetic process (GO:0044550)4.28333439
14neuronal ion channel clustering (GO:0045161)4.14711994
15regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.14312541
16endothelial cell differentiation (GO:0045446)4.12242592
17glomerular filtration (GO:0003094)3.94896870
18lymphangiogenesis (GO:0001946)3.94130403
19negative regulation of chondrocyte differentiation (GO:0032331)3.93162879
20cardiac myofibril assembly (GO:0055003)3.88946502
21planar cell polarity pathway involved in neural tube closure (GO:0090179)3.81556186
22cell proliferation involved in kidney development (GO:0072111)3.78169711
23dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.75500151
24craniofacial suture morphogenesis (GO:0097094)3.69508157
25dermatan sulfate biosynthetic process (GO:0030208)3.68785317
26paraxial mesoderm development (GO:0048339)3.68304364
27endodermal cell differentiation (GO:0035987)3.65269204
28chondrocyte development (GO:0002063)3.62820066
29extracellular negative regulation of signal transduction (GO:1900116)3.62497786
30extracellular regulation of signal transduction (GO:1900115)3.62497786
31regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.61302902
32G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.59989219
33heart morphogenesis (GO:0003007)3.57310863
34plasma membrane repair (GO:0001778)3.55659470
35renal filtration (GO:0097205)3.52870425
36desmosome organization (GO:0002934)3.50986101
37hemidesmosome assembly (GO:0031581)3.49439648
38mesenchymal cell proliferation (GO:0010463)3.49137166
39mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.47534715
40hippo signaling (GO:0035329)3.46499411
41vascular endothelial growth factor signaling pathway (GO:0038084)3.46353938
42dermatan sulfate metabolic process (GO:0030205)3.45082573
43extracellular fibril organization (GO:0043206)3.42970693
44proximal/distal pattern formation (GO:0009954)3.41780877
45collagen metabolic process (GO:0032963)3.40433686
46branching involved in ureteric bud morphogenesis (GO:0001658)3.39831262
47blood vessel maturation (GO:0001955)3.39049205
48regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.37926210
49radial glial cell differentiation (GO:0060019)3.37744591
50trabecula formation (GO:0060343)3.32778518
51neuron projection extension involved in neuron projection guidance (GO:1902284)3.31716443
52axon extension involved in axon guidance (GO:0048846)3.31716443
53regulation of transforming growth factor beta2 production (GO:0032909)3.29851465
54collagen catabolic process (GO:0030574)3.27149131
55patterning of blood vessels (GO:0001569)3.24309863
56prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.21407538
57regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.20832939
58regulation of non-canonical Wnt signaling pathway (GO:2000050)3.20287294
59regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.18404685
60multicellular organismal macromolecule metabolic process (GO:0044259)3.17939024
61cell migration involved in heart development (GO:0060973)3.17059114
62regulation of cardioblast differentiation (GO:0051890)3.16169589
63negative regulation of cartilage development (GO:0061037)3.14531873
64retina vasculature morphogenesis in camera-type eye (GO:0061299)3.12740267
65endothelium development (GO:0003158)3.11991478
66cell migration involved in sprouting angiogenesis (GO:0002042)3.11618606
67extracellular matrix disassembly (GO:0022617)3.11159606
68insulin-like growth factor receptor signaling pathway (GO:0048009)3.07294963
69regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.05318623
70glial cell migration (GO:0008347)3.04650364
71cell-substrate junction assembly (GO:0007044)3.04242867
72glomerular basement membrane development (GO:0032836)3.03814930
73multicellular organismal metabolic process (GO:0044236)3.02136560
74cardiac muscle tissue development (GO:0048738)3.01872810
75myofibril assembly (GO:0030239)2.99553682
76substrate adhesion-dependent cell spreading (GO:0034446)2.98342798
77protein heterotrimerization (GO:0070208)2.97315077
78multicellular organismal catabolic process (GO:0044243)2.96426411
79outer ear morphogenesis (GO:0042473)2.94159950
80G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.92891719
81appendage morphogenesis (GO:0035107)2.92278384
82limb morphogenesis (GO:0035108)2.92278384
83chondrocyte differentiation (GO:0002062)2.91510236
84adherens junction assembly (GO:0034333)2.91226431
85regulation of heart morphogenesis (GO:2000826)2.89787449
86regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.89707773
87mesenchyme morphogenesis (GO:0072132)2.89034930
88negative regulation of axon extension involved in axon guidance (GO:0048843)2.88097287
89smooth muscle tissue development (GO:0048745)2.87516593
90negative regulation of catenin import into nucleus (GO:0035414)2.87433467
91fibril organization (GO:0097435)2.86172988
92metanephric mesenchyme development (GO:0072075)2.86006613
93embryonic cranial skeleton morphogenesis (GO:0048701)2.85515831
94chondrocyte proliferation (GO:0035988)2.85470048
95negative regulation of hormone biosynthetic process (GO:0032353)2.84969130
96morphogenesis of an epithelial sheet (GO:0002011)2.84736962
97gap junction assembly (GO:0016264)2.83559846
98hindlimb morphogenesis (GO:0035137)2.83462783
99bundle of His cell to Purkinje myocyte communication (GO:0086069)2.83379572
100kidney mesenchyme development (GO:0072074)2.82585884
101cell-substrate adherens junction assembly (GO:0007045)2.80701135
102focal adhesion assembly (GO:0048041)2.80701135
103Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.79621527
104male genitalia development (GO:0030539)2.79098913
105embryonic appendage morphogenesis (GO:0035113)2.78741980
106embryonic limb morphogenesis (GO:0030326)2.78741980
107endochondral ossification (GO:0001958)2.78130708
108replacement ossification (GO:0036075)2.78130708
109positive regulation of mesenchymal cell proliferation (GO:0002053)2.77641087
110cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.77010039
111regulation of mesenchymal cell proliferation (GO:0010464)2.76403769
112regulation of chondrocyte differentiation (GO:0032330)2.76261782
113positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.75822318
114mesenchymal cell differentiation (GO:0048762)2.74894112
115blood vessel endothelial cell migration (GO:0043534)2.74131271
116cranial suture morphogenesis (GO:0060363)2.74044784
117head development (GO:0060322)2.73515016
118somite development (GO:0061053)2.72524234
119vasculogenesis (GO:0001570)2.72317421
120dorsal/ventral axis specification (GO:0009950)2.72228132
121semaphorin-plexin signaling pathway (GO:0071526)2.72131755
122regulation of establishment of planar polarity (GO:0090175)2.71725382
123surfactant homeostasis (GO:0043129)2.71660102
124regulation of endothelial cell differentiation (GO:0045601)2.71135206
125midgut development (GO:0007494)2.70899652
126pathway-restricted SMAD protein phosphorylation (GO:0060389)2.69833419
127endothelial cell morphogenesis (GO:0001886)2.68964754
128adult heart development (GO:0007512)2.67664852
129endocardial cushion morphogenesis (GO:0003203)2.67587079
130regulation of cartilage development (GO:0061035)2.67100285
131heart trabecula formation (GO:0060347)2.66694160
132negative regulation of stem cell proliferation (GO:2000647)2.66633721
133cell surface receptor signaling pathway involved in heart development (GO:0061311)2.65961726
134negative regulation of hormone metabolic process (GO:0032351)2.65582880
135tyrosine metabolic process (GO:0006570)2.65552022
136keratan sulfate catabolic process (GO:0042340)2.63412161
137chondroitin sulfate catabolic process (GO:0030207)2.61917188
138positive regulation of epithelial to mesenchymal transition (GO:0010718)2.61111748
139negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.60912977
140negative regulation of fatty acid transport (GO:2000192)2.60703558
141melanocyte differentiation (GO:0030318)2.58409165
142peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.58387152
143skin morphogenesis (GO:0043589)2.58275085
144regulation of glucocorticoid metabolic process (GO:0031943)2.57991964
145embryonic foregut morphogenesis (GO:0048617)2.56510839
146artery development (GO:0060840)2.55911906
147extracellular matrix assembly (GO:0085029)2.52951276
148endocardial cushion development (GO:0003197)2.52480374
149extracellular matrix organization (GO:0030198)2.52429513
150face morphogenesis (GO:0060325)2.51992618
151extracellular structure organization (GO:0043062)2.51563035
152artery morphogenesis (GO:0048844)2.48964034
153pigment cell differentiation (GO:0050931)2.48046313
154protein localization to cell surface (GO:0034394)2.47255796
155wound healing, spreading of epidermal cells (GO:0035313)2.46578287
156wound healing (GO:0042060)2.46558948
157substrate-dependent cell migration (GO:0006929)2.45956288
158regulation of cardiac muscle cell differentiation (GO:2000725)2.45793655
159chondroitin sulfate biosynthetic process (GO:0030206)2.45393501
160genitalia morphogenesis (GO:0035112)2.44301659
161neuron remodeling (GO:0016322)2.43341044

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.08391180
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.22140340
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.00520042
4EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.77366627
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.70103252
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.56889246
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.55454874
8ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.52939355
9* EP300_21415370_ChIP-Seq_HL-1_Mouse2.51848681
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.40814623
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.31142343
12PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.11175250
13HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.06739516
14* WT1_19549856_ChIP-ChIP_CCG9911_Human2.03367535
15RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.01725080
16CDX2_19796622_ChIP-Seq_MESCs_Mouse1.98157598
17RNF2_18974828_ChIP-Seq_MESCs_Mouse1.94036504
18EZH2_18974828_ChIP-Seq_MESCs_Mouse1.94036504
19PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.93239106
20EZH2_27304074_Chip-Seq_ESCs_Mouse1.89285477
21TP63_19390658_ChIP-ChIP_HaCaT_Human1.88739297
22CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.88476745
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.82998489
24* ISL1_27105846_Chip-Seq_CPCs_Mouse1.81738322
25SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.80409062
26BP1_19119308_ChIP-ChIP_Hs578T_Human1.76890898
27SALL1_21062744_ChIP-ChIP_HESCs_Human1.75632204
28ESR1_20079471_ChIP-ChIP_T-47D_Human1.74836404
29SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.74130866
30* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.73275240
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.67946201
32JARID2_20064375_ChIP-Seq_MESCs_Mouse1.65592987
33TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.65445333
34RNF2_27304074_Chip-Seq_ESCs_Mouse1.63497709
35CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.59114729
36RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58747539
37WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.58353569
38* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.57445917
39NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.57168678
40ZNF263_19887448_ChIP-Seq_K562_Human1.56315941
41SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.55042692
42GATA2_21666600_ChIP-Seq_HMVEC_Human1.54234251
43BRD4_25478319_ChIP-Seq_HGPS_Human1.49192320
44JARID2_20075857_ChIP-Seq_MESCs_Mouse1.48445396
45RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.47304066
46* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45921227
47SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.44546017
48DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.42567894
49SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.41396488
50* CJUN_26792858_Chip-Seq_BT549_Human1.40662368
51TP53_20018659_ChIP-ChIP_R1E_Mouse1.40093710
52* TBX20_22080862_ChIP-Seq_HEART_Mouse1.38641098
53* TBX20_22328084_ChIP-Seq_HEART_Mouse1.38641098
54FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.37884343
55CLOCK_20551151_ChIP-Seq_293T_Human1.37573454
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.35180694
57AHR_22903824_ChIP-Seq_MCF-7_Human1.34874188
58RARG_19884340_ChIP-ChIP_MEFs_Mouse1.34623546
59* TCF4_18268006_ChIP-ChIP_LS174T_Human1.33320672
60TP53_18474530_ChIP-ChIP_U2OS_Human1.32956769
61TP53_16413492_ChIP-PET_HCT116_Human1.32342115
62SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.32185121
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32172385
64* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.31863691
65POU5F1_16153702_ChIP-ChIP_HESCs_Human1.30761538
66TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.28987298
67ZFP281_27345836_Chip-Seq_ESCs_Mouse1.24450241
68ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.23264753
69* SMAD3_21741376_ChIP-Seq_HESCs_Human1.23138329
70AR_21572438_ChIP-Seq_LNCaP_Human1.22974816
71* PIAS1_25552417_ChIP-Seq_VCAP_Human1.22903038
72* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.21466120
73TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.20950910
74* RING1B_27294783_Chip-Seq_NPCs_Mouse1.20816276
75SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.19845928
76MTF2_20144788_ChIP-Seq_MESCs_Mouse1.18337813
77NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.17566563
78CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.17202964
79BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.17050112
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.16722327
81ARNT_22903824_ChIP-Seq_MCF-7_Human1.16607045
82* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15971760
83TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15642664
84RING1B_27294783_Chip-Seq_ESCs_Mouse1.15258049
85NFIB_24661679_ChIP-Seq_LUNG_Mouse1.14638214
86NRF2_20460467_ChIP-Seq_MEFs_Mouse1.13356048
87NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.13356048
88SALL4_18804426_ChIP-ChIP_XEN_Mouse1.12852168
89SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12486456
90TBX3_20139965_ChIP-Seq_ESCs_Mouse1.11979243
91SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11207757
92* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11204691
93CTNNB1_20460455_ChIP-Seq_HCT116_Human1.10744147
94TBX3_20139965_ChIP-Seq_MESCs_Mouse1.10379463
95SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.09320551
96SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.09320551
97TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08076092
98* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07440795
99TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06094964
100STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.05695417
101ESR2_21235772_ChIP-Seq_MCF-7_Human1.05476835
102SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.03381462
103* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.02587995
104PPAR_26484153_Chip-Seq_NCI-H1993_Human1.01884052
105NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01379035
106ELK3_25401928_ChIP-Seq_HUVEC_Human1.01165225
107EGR1_19374776_ChIP-ChIP_THP-1_Human1.00204927
108YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99771183
109EZH2_22144423_ChIP-Seq_EOC_Human0.99253799
110ESR1_21235772_ChIP-Seq_MCF-7_Human0.98957813
111TP63_23658742_ChIP-Seq_EP156T_Human0.98392167
112P300_19829295_ChIP-Seq_ESCs_Human0.97904025
113BCAT_22108803_ChIP-Seq_LS180_Human0.97893264
114KDM2B_26808549_Chip-Seq_K562_Human0.97884117
115* SMAD4_21799915_ChIP-Seq_A2780_Human0.97641736
116RXR_22108803_ChIP-Seq_LS180_Human0.97183971
117* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.96975665
118PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96668207
119STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.96466515
120DROSHA_22980978_ChIP-Seq_HELA_Human0.93538607
121* MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.93157323
122GBX2_23144817_ChIP-Seq_PC3_Human0.92711204

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004272_abnormal_basement_membrane5.37475231
2MP0010368_abnormal_lymphatic_system4.64416954
3MP0003279_aneurysm3.49827515
4MP0005503_abnormal_tendon_morphology3.40846362
5MP0004145_abnormal_muscle_electrophysio3.30807557
6MP0003941_abnormal_skin_development3.24025898
7MP0003705_abnormal_hypodermis_morpholog3.21171982
8MP0008438_abnormal_cutaneous_collagen3.09814601
9MP0005171_absent_coat_pigmentation2.97101399
10MP0001879_abnormal_lymphatic_vessel2.85441273
11MP0000569_abnormal_digit_pigmentation2.83485599
12MP0005408_hypopigmentation2.73667721
13MP0002938_white_spotting2.64686119
14MP0009250_abnormal_appendicular_skeleto2.57255576
15MP0005275_abnormal_skin_tensile2.30491289
16MP0010030_abnormal_orbit_morphology2.29712086
17MP0003122_maternal_imprinting2.29637333
18MP0003942_abnormal_urinary_system2.16332012
19MP0000015_abnormal_ear_pigmentation2.09169743
20MP0003385_abnormal_body_wall2.04554821
21MP0002108_abnormal_muscle_morphology2.04209510
22MP0009780_abnormal_chondrocyte_physiolo1.99649765
23MP0000566_synostosis1.90260794
24MP0009053_abnormal_anal_canal1.85811338
25MP0000049_abnormal_middle_ear1.84762207
26MP0003136_yellow_coat_color1.82135623
27MP0005248_abnormal_Harderian_gland1.77739805
28MP0002282_abnormal_trachea_morphology1.77250497
29MP0005174_abnormal_tail_pigmentation1.74732066
30MP0000428_abnormal_craniofacial_morphol1.74617090
31MP0005187_abnormal_penis_morphology1.70288815
32MP0003828_pulmonary_edema1.70221450
33MP0005508_abnormal_skeleton_morphology1.58942756
34MP0002932_abnormal_joint_morphology1.57741235
35MP0003935_abnormal_craniofacial_develop1.56902352
36MP0000371_diluted_coat_color1.56516509
37MP0000537_abnormal_urethra_morphology1.55652031
38MP0004084_abnormal_cardiac_muscle1.50265004
39MP0003115_abnormal_respiratory_system1.49473640
40MP0001958_emphysema1.44087259
41MP0004381_abnormal_hair_follicle1.43115001
42MP0005623_abnormal_meninges_morphology1.41746379
43MP0002249_abnormal_larynx_morphology1.37182531
44MP0000534_abnormal_ureter_morphology1.36615621
45MP0003121_genomic_imprinting1.35085828
46MP0002877_abnormal_melanocyte_morpholog1.32292432
47MP0000767_abnormal_smooth_muscle1.31313473
48MP0004215_abnormal_myocardial_fiber1.30393564
49MP0003091_abnormal_cell_migration1.28840788
50MP0003937_abnormal_limbs/digits/tail_de1.27889142
51MP0003755_abnormal_palate_morphology1.27562936
52MP0002095_abnormal_skin_pigmentation1.26856416
53MP0001293_anophthalmia1.25417335
54MP0003123_paternal_imprinting1.23173744
55MP0006138_congestive_heart_failure1.22544073
56MP0010630_abnormal_cardiac_muscle1.21603304
57MP0000762_abnormal_tongue_morphology1.20259025
58MP0002109_abnormal_limb_morphology1.20180829
59MP0005023_abnormal_wound_healing1.20120414
60MP0002102_abnormal_ear_morphology1.18806866
61MP0000751_myopathy1.18623184
62MP0004134_abnormal_chest_morphology1.17363647
63MP0002896_abnormal_bone_mineralization1.16356065
64MP0002925_abnormal_cardiovascular_devel1.15655880
65MP0002116_abnormal_craniofacial_bone1.13829486
66MP0006054_spinal_hemorrhage1.13295285
67MP0005075_abnormal_melanosome_morpholog1.09328144
68MP0005409_darkened_coat_color1.09308923
69MP0000432_abnormal_head_morphology1.09258820
70MP0009379_abnormal_foot_pigmentation1.08401931
71MP0002075_abnormal_coat/hair_pigmentati1.08289470
72MP0000733_abnormal_muscle_development1.06516169
73MP0002972_abnormal_cardiac_muscle1.04230211
74MP0002697_abnormal_eye_size1.03522864
75MP0004087_abnormal_muscle_fiber1.03515896
76MP0005167_abnormal_blood-brain_barrier1.03203712
77MP0005197_abnormal_uvea_morphology1.03062890
78MP0002128_abnormal_blood_circulation1.02099027
79MP0010352_gastrointestinal_tract_polyps1.00823582
80MP0000516_abnormal_urinary_system1.00542368
81MP0005367_renal/urinary_system_phenotyp1.00542368
82MP0005330_cardiomyopathy1.00459317
83MP0004133_heterotaxia0.99758494
84MP0000383_abnormal_hair_follicle0.98783051
85MP0000163_abnormal_cartilage_morphology0.97089750
86MP0000266_abnormal_heart_morphology0.96346408
87MP0000462_abnormal_digestive_system0.96199766
88MP0001340_abnormal_eyelid_morphology0.96005107
89MP0003567_abnormal_fetal_cardiomyocyte0.95784292
90MP0001186_pigmentation_phenotype0.95712793
91MP0001299_abnormal_eye_distance/0.95156888
92MP0008775_abnormal_heart_ventricle0.94447873
93MP0002295_abnormal_pulmonary_circulatio0.94338235
94MP0001614_abnormal_blood_vessel0.94219464
95MP0002177_abnormal_outer_ear0.93032216
96MP0003566_abnormal_cell_adhesion0.92104699
97MP0002115_abnormal_skeleton_extremities0.91764227
98MP0004085_abnormal_heartbeat0.90979349
99MP0000013_abnormal_adipose_tissue0.90324079
100MP0002233_abnormal_nose_morphology0.89005135
101MP0000750_abnormal_muscle_regeneration0.87994149
102MP0001243_abnormal_dermal_layer0.87355980
103MP0004858_abnormal_nervous_system0.86650735
104MP0005257_abnormal_intraocular_pressure0.86341849
105MP0002098_abnormal_vibrissa_morphology0.85339847
106MP0002060_abnormal_skin_morphology0.84932431
107MP0005385_cardiovascular_system_phenoty0.83653040
108MP0001544_abnormal_cardiovascular_syste0.83653040
109MP0001175_abnormal_lung_morphology0.83524703
110MP0000579_abnormal_nail_morphology0.83168164
111MP0004197_abnormal_fetal_growth/weight/0.82236457
112MP0005369_muscle_phenotype0.79780860
113MP0005595_abnormal_vascular_smooth0.79419505
114MP0000372_irregular_coat_pigmentation0.76640200
115MP0002133_abnormal_respiratory_system0.76124916
116MP0005388_respiratory_system_phenotype0.76124916
117MP0001849_ear_inflammation0.75046604
118MP0002168_other_aberrant_phenotype0.74605341
119MP0000759_abnormal_skeletal_muscle0.73476022
120MP0001542_abnormal_bone_strength0.73398540
121MP0002127_abnormal_cardiovascular_syste0.72975638
122MP0003950_abnormal_plasma_membrane0.71788671
123MP0009384_cardiac_valve_regurgitation0.71458536
124MP0010678_abnormal_skin_adnexa0.70659472
125MP0001784_abnormal_fluid_regulation0.69976118
126MP0002092_abnormal_eye_morphology0.69936013
127MP0001346_abnormal_lacrimal_gland0.69897428
128MP0002114_abnormal_axial_skeleton0.67929016
129MP0001324_abnormal_eye_pigmentation0.67086619
130MP0005390_skeleton_phenotype0.65933336
131MP0000467_abnormal_esophagus_morphology0.65216024
132MP0001915_intracranial_hemorrhage0.65048386
133MP0000749_muscle_degeneration0.64077593
134MP0004036_abnormal_muscle_relaxation0.59947544
135MP0005193_abnormal_anterior_eye0.59258040
136MP0002113_abnormal_skeleton_development0.58155861

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)7.18878563
2Wrist flexion contracture (HP:0001239)5.19326290
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.86547757
4Short 4th metacarpal (HP:0010044)4.86547757
5Overgrowth (HP:0001548)4.70938367
6Broad metatarsal (HP:0001783)4.41902472
7Midline defect of the nose (HP:0004122)4.39944112
8Skull defect (HP:0001362)4.23085665
9Shallow orbits (HP:0000586)3.90741564
10Cerebral aneurysm (HP:0004944)3.81302235
11Hip contracture (HP:0003273)3.79697514
12Abnormality of the 4th metacarpal (HP:0010012)3.71788226
13Soft skin (HP:0000977)3.68716630
14Bladder diverticulum (HP:0000015)3.41647609
15Vascular tortuosity (HP:0004948)3.39414904
16Abnormality of the parietal bone (HP:0002696)3.33593834
17Arterial tortuosity (HP:0005116)3.33199350
18High pitched voice (HP:0001620)3.24443443
19Neoplasm of the oral cavity (HP:0100649)3.24131471
20Neonatal death (HP:0003811)3.20429823
21Long eyelashes (HP:0000527)3.20159416
22Neonatal short-limb short stature (HP:0008921)3.18512512
23Limited hip movement (HP:0008800)3.14708198
24Spinal rigidity (HP:0003306)3.04233614
25White forelock (HP:0002211)2.99092748
26Osteolytic defects of the phalanges of the hand (HP:0009771)2.93350882
27Osteolytic defects of the hand bones (HP:0009699)2.93350882
28Long clavicles (HP:0000890)2.90257320
29Absent eyebrow (HP:0002223)2.89529297
30Fragile skin (HP:0001030)2.88525194
31Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.84948162
32Trigonocephaly (HP:0000243)2.78959036
33Absent frontal sinuses (HP:0002688)2.76248524
34Short phalanx of the thumb (HP:0009660)2.76134965
35Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.72991363
36Short 1st metacarpal (HP:0010034)2.72991363
37Blue irides (HP:0000635)2.72335381
38Abnormality of the nasolacrimal system (HP:0000614)2.72166868
39Aplasia/Hypoplasia of the fovea (HP:0008060)2.71616245
40Hypoplasia of the fovea (HP:0007750)2.71616245
41Abnormality of the lacrimal duct (HP:0011481)2.68469216
42Myotonia (HP:0002486)2.68215589
43Genu recurvatum (HP:0002816)2.65993503
44Abnormality of dentin (HP:0010299)2.61647380
45Abnormal vertebral ossification (HP:0100569)2.57312265
46Aplasia/Hypoplasia of the macula (HP:0008059)2.54644059
47Cutaneous finger syndactyly (HP:0010554)2.51835894
48Ectopia lentis (HP:0001083)2.48847044
49Ulnar bowing (HP:0003031)2.48787623
50Patchy hypopigmentation of hair (HP:0011365)2.47209444
51Joint contractures involving the joints of the feet (HP:0100492)2.47119143
52Flexion contracture of toe (HP:0005830)2.47119143
53Follicular hyperkeratosis (HP:0007502)2.45684741
54Laryngomalacia (HP:0001601)2.43897633
55Cervical subluxation (HP:0003308)2.43805332
56Joint laxity (HP:0001388)2.37355248
57Asymmetry of the thorax (HP:0001555)2.34771450
58Aplasia/Hypoplasia affecting the retina (HP:0008061)2.33226032
59Hyperextensible skin (HP:0000974)2.33220435
60Aortic dissection (HP:0002647)2.32461369
61Peritonitis (HP:0002586)2.32097086
62Aortic aneurysm (HP:0004942)2.29598867
63Abnormality of the 1st metacarpal (HP:0010009)2.28893258
64Hypopigmentation of the fundus (HP:0007894)2.26443997
65Ankle contracture (HP:0006466)2.26316304
66Lymphangioma (HP:0100764)2.26226306
67Hypoplasia of the iris (HP:0007676)2.26223964
68Morphological abnormality of the middle ear (HP:0008609)2.26143518
69Pulmonary artery stenosis (HP:0004415)2.25391099
70Absent eyelashes (HP:0000561)2.23888587
71Spinal cord lesions (HP:0100561)2.22955963
72Syringomyelia (HP:0003396)2.22955963
73Trismus (HP:0000211)2.21386548
74Bell-shaped thorax (HP:0001591)2.20727622
75Vertebral clefting (HP:0008428)2.19727364
76Biconcave vertebral bodies (HP:0004586)2.17932506
77Thin bony cortex (HP:0002753)2.17744449
78Narrow palate (HP:0000189)2.17376792
79Cutaneous syndactyly (HP:0012725)2.14885375
80Aplasia cutis congenita (HP:0001057)2.13542944
81Camptodactyly of toe (HP:0001836)2.12479670
82Coxa vara (HP:0002812)2.10307918
83Abnormality of the nasal septum (HP:0000419)2.10289311
84Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.10249076
85Nasolacrimal duct obstruction (HP:0000579)2.08699768
86Increased connective tissue (HP:0009025)2.07210262
87Type 1 muscle fiber predominance (HP:0003803)2.06797135
88Bowel diverticulosis (HP:0005222)2.05583200
89Bilateral microphthalmos (HP:0007633)2.04879215
90Natal tooth (HP:0000695)2.04686530
91Abnormality of the fovea (HP:0000493)2.04637426
92Flat cornea (HP:0007720)2.02351061
93Mitral valve prolapse (HP:0001634)1.98781605
94Wormian bones (HP:0002645)1.97941801
95Mild short stature (HP:0003502)1.97693998
96Abnormality of the acetabulum (HP:0003170)1.97582562
97Tracheal stenosis (HP:0002777)1.97307085
98Broad toe (HP:0001837)1.96742950
99Aortic regurgitation (HP:0001659)1.95704619
100Disproportionate tall stature (HP:0001519)1.95126689
101Sudden death (HP:0001699)1.94750422
102Atrophic scars (HP:0001075)1.94185457
103Wide anterior fontanel (HP:0000260)1.93880807
104Abnormality of the distal phalanx of the thumb (HP:0009617)1.93628917
105Vitreoretinal degeneration (HP:0000655)1.93480108
106Sprengel anomaly (HP:0000912)1.93080216
107Ventricular tachycardia (HP:0004756)1.91755294
108Elbow flexion contracture (HP:0002987)1.91536201
109Vertebral compression fractures (HP:0002953)1.90986618
110Renal duplication (HP:0000075)1.90193135
111Mitral stenosis (HP:0001718)1.90168567
112Hypoplastic ischia (HP:0003175)1.89685335
113Abnormal delivery (HP:0001787)1.89516824
114Hepatoblastoma (HP:0002884)1.89219996
115Broad long bones (HP:0005622)1.88942029
116Premature rupture of membranes (HP:0001788)1.88302577
117Osteoarthritis (HP:0002758)1.87386955
118Aneurysm (HP:0002617)1.86846200
119Anteriorly placed anus (HP:0001545)1.85494656
120Supernumerary ribs (HP:0005815)1.84610565
121Vertebral arch anomaly (HP:0008438)1.84428294
122Spondylolisthesis (HP:0003302)1.82340167
123Mesomelia (HP:0003027)1.82325174
124Short middle phalanx of finger (HP:0005819)1.82068763
125Anophthalmia (HP:0000528)1.81729834
126Abnormality of the pubic bones (HP:0003172)1.81578629
127Coronal craniosynostosis (HP:0004440)1.81097981
128Right ventricular cardiomyopathy (HP:0011663)1.79927496
129Flat face (HP:0012368)1.79451905
130Blue sclerae (HP:0000592)1.78725163
131Broad palm (HP:0001169)1.78362030
132Mitral regurgitation (HP:0001653)1.77600456
133Ocular albinism (HP:0001107)1.77505997
134Breech presentation (HP:0001623)1.76733814
135Muscle fiber splitting (HP:0003555)1.76567258
136Narrow chest (HP:0000774)1.76505045
137Hypoplasia of the maxilla (HP:0000327)1.75861018
138Striae distensae (HP:0001065)1.75493470
139Broad ribs (HP:0000885)1.73481285
140Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.72788811
141Lipoatrophy (HP:0100578)1.72343810
142Renovascular hypertension (HP:0100817)1.72115133
143Down-sloping shoulders (HP:0200021)1.71694890
144Exostoses (HP:0100777)1.70993933
145Aortic valve stenosis (HP:0001650)1.70416639
146Dilatation of the ascending aorta (HP:0005111)1.69927241
147Abnormality of the sella turcica (HP:0002679)1.69692527
148Round ear (HP:0100830)1.69592556
149Abnormality of skull ossification (HP:0002703)1.69291568
150Deep philtrum (HP:0002002)1.68180356
151Broad phalanx (HP:0006009)1.67937223
152Abnormality of the ischium (HP:0003174)1.67449574
153Abnormality of the middle phalanges of the hand (HP:0009833)1.66956172
154Decreased skull ossification (HP:0004331)1.65520232
155Hallux valgus (HP:0001822)1.64338787
156Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.63115730
157Dislocated radial head (HP:0003083)1.62375220
158Mildly elevated creatine phosphokinase (HP:0008180)1.62277321
159Deviation of the hallux (HP:0010051)1.62041029

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE18.25771277
2SCYL26.45095588
3LATS13.57452617
4KDR3.34423318
5FGFR22.54846824
6SIK22.33969119
7FLT32.29368963
8EPHB22.25968241
9TGFBR22.07586603
10PDGFRA1.92521180
11EEF2K1.90867979
12DDR21.77381537
13TGFBR11.75966849
14DMPK1.73740284
15EPHA31.71322384
16ICK1.68492393
17RIPK11.63159707
18TTN1.61147471
19NTRK11.60528570
20CDK121.57680473
21ZAK1.51516185
22PKN21.45657435
23FGFR11.35335760
24STK31.33655066
25PTK61.30567671
26OBSCN1.28278467
27PIK3CA1.22126746
28FER1.21868516
29CAMK1G1.20675143
30TRIB31.19482291
31SIK11.19057204
32CAMK1D1.17709345
33STK38L1.16717214
34MAP3K61.15203266
35NEK21.14256104
36PTK2B1.13616075
37RET1.11294984
38RPS6KA21.06564109
39NUAK11.05823582
40LATS21.02389668
41MET1.00790082
42BMX0.98184001
43INSRR0.95355159
44BRD40.91915595
45ERBB30.91667490
46PDGFRB0.91204951
47MAP3K100.89225879
48TYRO30.85374031
49MKNK10.84001646
50FGFR30.83161914
51MYLK0.81142567
52CSNK1A1L0.80605657
53STK380.79259704
54PTK20.76299608
55PRKD10.75097194
56STK240.74943072
57PRKD30.73574035
58MELK0.71283680
59MST1R0.71259939
60PAK40.70074320
61MTOR0.69087658
62PIK3CG0.67291341
63ERBB40.64668020
64NEK90.63739507
65DYRK1B0.63683005
66WNK10.63133153
67EPHB10.60727842
68LMTK20.59871279
69MAP3K20.59358362
70MKNK20.59157795
71STK40.58379753
72MARK20.56477514
73PRKCH0.56081166
74FRK0.54859725
75CDC42BPA0.54175764
76CAMK40.51686406
77RPS6KL10.51122101
78RPS6KC10.51122101
79PRKD20.50238612
80PRKCE0.49853037
81PRKAA20.49676374
82CDK60.49419649
83ROCK10.48711909
84SGK2230.47981745
85SGK4940.47981745
86BMPR1B0.45445000
87KIT0.45125973
88PAK20.43259643
89SGK30.42449458
90SGK20.41476381
91RPS6KA60.41286426
92NLK0.40616611
93TRPM70.40306660
94DYRK1A0.39808786
95MAP3K70.39792770
96FGFR40.37867302
97ROCK20.34828438
98GSK3A0.34816329
99MAP3K30.33703118
100CSNK1G10.33482966
101AKT30.33393196
102MAP2K10.32440485
103RPS6KB10.32201587
104SRC0.31979064
105MOS0.31944788
106MARK30.31813146
107MAPK70.31810401
108ILK0.31533331
109CDK90.30099955
110CHUK0.30031251
111ERBB20.29888436
112IGF1R0.29650847
113MAPK100.28954026
114MAP2K30.28335398
115GRK10.28299799
116BRSK20.28103731
117TAOK20.27957579
118AKT20.26910065
119PAK30.26158047
120CLK10.25556589
121MAPK10.25436026
122INSR0.25062724
123AKT10.23748046
124EIF2AK20.21358149
125PRKG20.21269035
126CDK70.21206413
127ATM0.21202989
128LRRK20.20762656
129MAPK80.18676908
130PRKACB0.18488827
131RPS6KB20.17545120

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045125.33627162
2Basal cell carcinoma_Homo sapiens_hsa052173.42804298
3Adherens junction_Homo sapiens_hsa045202.82310120
4Small cell lung cancer_Homo sapiens_hsa052222.81203146
5Focal adhesion_Homo sapiens_hsa045102.69670308
6Hedgehog signaling pathway_Homo sapiens_hsa043402.66071620
7Dilated cardiomyopathy_Homo sapiens_hsa054142.61223678
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.47858045
9Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.47028257
10Amoebiasis_Homo sapiens_hsa051462.34291087
11Proteoglycans in cancer_Homo sapiens_hsa052052.16175310
12Hippo signaling pathway_Homo sapiens_hsa043902.02013089
13Viral myocarditis_Homo sapiens_hsa054161.89995275
14TGF-beta signaling pathway_Homo sapiens_hsa043501.87550449
15Axon guidance_Homo sapiens_hsa043601.78856024
16Toxoplasmosis_Homo sapiens_hsa051451.75313863
17Pathways in cancer_Homo sapiens_hsa052001.74511183
18Wnt signaling pathway_Homo sapiens_hsa043101.65484966
19Protein digestion and absorption_Homo sapiens_hsa049741.63244774
20MicroRNAs in cancer_Homo sapiens_hsa052061.60409264
21Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.57869964
22PI3K-Akt signaling pathway_Homo sapiens_hsa041511.54846876
23Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.51867658
24Notch signaling pathway_Homo sapiens_hsa043301.49921520
25Tight junction_Homo sapiens_hsa045301.49255265
26Lysine degradation_Homo sapiens_hsa003101.47277174
27Melanogenesis_Homo sapiens_hsa049161.43523898
28Rap1 signaling pathway_Homo sapiens_hsa040151.41371068
29Melanoma_Homo sapiens_hsa052181.35666574
30AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.35385625
31Prostate cancer_Homo sapiens_hsa052151.35157269
32Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.22945902
33Glycosaminoglycan degradation_Homo sapiens_hsa005311.22696314
34Leukocyte transendothelial migration_Homo sapiens_hsa046701.19867294
35Transcriptional misregulation in cancer_Homo sapiens_hsa052021.16959101
36Chronic myeloid leukemia_Homo sapiens_hsa052201.11635995
37Thyroid hormone signaling pathway_Homo sapiens_hsa049191.05395504
38Regulation of actin cytoskeleton_Homo sapiens_hsa048101.04682776
39cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04682546
40Colorectal cancer_Homo sapiens_hsa052101.03873862
41Platelet activation_Homo sapiens_hsa046110.99722339
42Choline metabolism in cancer_Homo sapiens_hsa052310.99411807
43Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.97432364
44Renin secretion_Homo sapiens_hsa049240.96519077
45Dorso-ventral axis formation_Homo sapiens_hsa043200.96140354
46HTLV-I infection_Homo sapiens_hsa051660.96095000
47Endometrial cancer_Homo sapiens_hsa052130.95747725
48Complement and coagulation cascades_Homo sapiens_hsa046100.91166930
49Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.89696803
50Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.89613066
51Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88998203
52Insulin resistance_Homo sapiens_hsa049310.87551598
53cAMP signaling pathway_Homo sapiens_hsa040240.85836551
54mTOR signaling pathway_Homo sapiens_hsa041500.81841060
55Ovarian steroidogenesis_Homo sapiens_hsa049130.80997065
56Tyrosine metabolism_Homo sapiens_hsa003500.79890623
57Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.78734097
58Hepatitis B_Homo sapiens_hsa051610.77429882
59African trypanosomiasis_Homo sapiens_hsa051430.74473330
60Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73719431
61Renal cell carcinoma_Homo sapiens_hsa052110.73461618
62ABC transporters_Homo sapiens_hsa020100.73299326
63Thyroid cancer_Homo sapiens_hsa052160.72277754
64Inositol phosphate metabolism_Homo sapiens_hsa005620.71266458
65Vascular smooth muscle contraction_Homo sapiens_hsa042700.71159116
66Glioma_Homo sapiens_hsa052140.69134047
67Ras signaling pathway_Homo sapiens_hsa040140.67976260
68Pancreatic cancer_Homo sapiens_hsa052120.63520379
69Cell cycle_Homo sapiens_hsa041100.60806076
70Estrogen signaling pathway_Homo sapiens_hsa049150.57268421
71p53 signaling pathway_Homo sapiens_hsa041150.56369052
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.56123651
73Gap junction_Homo sapiens_hsa045400.54524026
74FoxO signaling pathway_Homo sapiens_hsa040680.53708562
75Prolactin signaling pathway_Homo sapiens_hsa049170.52787560
76Systemic lupus erythematosus_Homo sapiens_hsa053220.52188417
77Prion diseases_Homo sapiens_hsa050200.51739578
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51611429
79HIF-1 signaling pathway_Homo sapiens_hsa040660.49707265
80MAPK signaling pathway_Homo sapiens_hsa040100.49183312
81Sphingolipid metabolism_Homo sapiens_hsa006000.48069702
82Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47842697
83Salivary secretion_Homo sapiens_hsa049700.47049546
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46676868
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46448380
86Other glycan degradation_Homo sapiens_hsa005110.46093423
87Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.45238746
88Cardiac muscle contraction_Homo sapiens_hsa042600.45024348
89Oxytocin signaling pathway_Homo sapiens_hsa049210.44820457
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.44506047
91Malaria_Homo sapiens_hsa051440.41980754
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41584948
93Bladder cancer_Homo sapiens_hsa052190.41136332
94Type II diabetes mellitus_Homo sapiens_hsa049300.40542880
95VEGF signaling pathway_Homo sapiens_hsa043700.40517883
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.40044597
97Circadian rhythm_Homo sapiens_hsa047100.39779514
98TNF signaling pathway_Homo sapiens_hsa046680.39408114
99Non-small cell lung cancer_Homo sapiens_hsa052230.38831684
100Salmonella infection_Homo sapiens_hsa051320.37876003
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37368204
102Insulin signaling pathway_Homo sapiens_hsa049100.37132525
103AMPK signaling pathway_Homo sapiens_hsa041520.36840120
104Renin-angiotensin system_Homo sapiens_hsa046140.36576789
105Viral carcinogenesis_Homo sapiens_hsa052030.35609968
106Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.34743567
107Alcoholism_Homo sapiens_hsa050340.33979232
108Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.33826731
109Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.33410957
110Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.31468449
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.30871004
112Calcium signaling pathway_Homo sapiens_hsa040200.30576950
113Glucagon signaling pathway_Homo sapiens_hsa049220.29273218
114ErbB signaling pathway_Homo sapiens_hsa040120.27197184
115GnRH signaling pathway_Homo sapiens_hsa049120.27031094
116Acute myeloid leukemia_Homo sapiens_hsa052210.23967370
117Circadian entrainment_Homo sapiens_hsa047130.23686605
118Thyroid hormone synthesis_Homo sapiens_hsa049180.20285626
119Oocyte meiosis_Homo sapiens_hsa041140.19672570
120Fatty acid degradation_Homo sapiens_hsa000710.19633354
121Endocytosis_Homo sapiens_hsa041440.19359055

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